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2.
Medicine (Baltimore) ; 98(45): e17907, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31702667

RESUMO

BACKGROUND: This study will evaluate diagnostic accuracy and management outcome studies involving patients assessed with prenatal ultrasound diagnosis (PUD) for fetal renal abnormalities (FRA). METHODS: We will search the following electronic databases of MEDLINE, EMBASE, Cochrane Library, Web of Science, Springer, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for diagnostic accuracy studies from inceptions to the present without language restrictions. Two authors will independently screen studies, collect data, and assess methodological quality.We will use RevMan V.5.3 and Stata V.12.0 software for data pooling and statistical analysis. RESULTS: In this study, we will assess sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio to determine the diagnostic accuracy of PUD for the treatment of patients with FRA. CONCLUSION: This study will provide latest evidence for the diagnostic accuracy of PUD for FRA. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019151306.


Assuntos
Nefropatias/diagnóstico , Rim/anormalidades , Ultrassonografia Pré-Natal , Feminino , Humanos , Rim/diagnóstico por imagem , Nefropatias/congênito , Nefropatias/embriologia , Gravidez , Revisão Sistemática como Assunto
3.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 7-11, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630707

RESUMO

The purpose of this article is to review the main congenital anomalies of kidneys and urinary tract that can be diagnosed prenatally and postnatally by imaging technique. The incidence of congenital anomalies of the kidney and urinary tract during the past decade has been estimated to be 0.4 to 4.0 cases per 1000 births. Congenital kidney disease can evolve in chronic disease in childhood and in adulthood. A diagnostic imaging of the various congenital renal and urological conditions allows pediatricians to make a correct diagnosis and treatment. Because of the concerns about long-term effects of ionizing radiation, the most commonly and first used imaging modality for evaluation of the urinary system is ultrasound.


Assuntos
Nefropatias/congênito , Nefropatias/diagnóstico por imagem , Rim/patologia , Sistema Urinário/patologia , Humanos , Recém-Nascido , Rim/diagnóstico por imagem , Pediatria , Sistema Urinário/diagnóstico por imagem
4.
Pan Afr Med J ; 33: 178, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31565139

RESUMO

Crossed renal ectopia is a rare congenital abnormality, in which the two kidneys are located in the same side. One of the ureters, whose length is adapted to the kidney seat, crosses the median line to implant in the bladder on the opposite side. Renal fusion of the two parenchymas is common and this abnormality is most often asymptomatic and fortuitously discovered. We report the case of a 36-year old patient with no previous pathological history, presenting with crossed renal ectopia incidentally discovered after acute cholecystitis complicated by perivescicular abscess. On the basis of this observation and of the data from the literature, we here discuss the etiopathogenic, clinical, radiological and therapeutic features of this malformation.


Assuntos
Colecistite Aguda/diagnóstico por imagem , Rim/anormalidades , Ureter/anormalidades , Abscesso/diagnóstico por imagem , Adulto , Humanos , Achados Incidentais , Rim/diagnóstico por imagem , Masculino , Ureter/diagnóstico por imagem
5.
Br J Radiol ; 92(1104): 20190425, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31593482

RESUMO

OBJECTIVE: Overexpression of human epidermal growth factor receptor-2 (HER2) in breast cancers provides promising opportunities for imaging and targeted therapy. Developing HER2 targeted positron emission tomography (PET) probes might be benefit for management of the disease. Small high-affinity scaffold proteins, affibodies, are ideal vectors for imaging HER2 overexpressed tumors. Despite of the initial success on development of 18F labeled ZHER2:342 affibody, the tedious synthesis producers, low yields and unfavorable pharmacokinetics may hinder the clinical use. 68Ga is an attractive positron emitter for PET imaging. A simple preparation of 68Ga labeled ZHER2:342 analog, 68Ga-NOTA-MAL-Cys-MZHER2:342, was reported in the study. The in vivo performances of the tracer for assessing HER2 status in breast cancers were also evaluated. METHODS: NOTA-MAL conjugated Cys-MZHER2:342 was radiolabeled with 68Ga. The probe was evaluated by in vitro tests including stability and cell binding studies in breast cancer cells with different HER2 levels. In vivo evaluation was performed in mice bearing tumors using microPET imaging and biodistribution experiments. A PET/CT imaging study was initially performed in patients with breast cancers. RESULTS: The tracer was synthesized in a straightforward chelation method with satisfactory non-decay corrected yield (81±5%) and radiochemical purity (>95%). In vivo micro-PET imaging showed that HER2 high levels expressed BT474 xenografts were more clear visualized than HER2 low levels expressed MCF-7 tumors (16.12 ± 2.69 ID%/g vs 1.32 ± 0.19 ID%/g at 1 h post-injection). The outcome was consistent with the immunohistochemical analysis. No significant radioactivity was accumulated in healthy tissues (less than 2% ID/g) except kidneys. In a preliminary clinical study, 68Ga-NOTA-MAL-Cys-MZHER2:342 PET imaging allowed more high-contrast detection of HER2 positive primary tumors (maximum standardized uptake value = 2.16±0.27) than those in HER2 negative primary focus (maximum standardized uptake value = 0.32±0.05). No detectable side-effects were found. CONCLUSION: In summary, this study indicates the significant efficiency of the 68Ga labeled HER2 affibody. Preclinical and clinical studies support the possibility of monitoring HER2 levels in breast cancers using 68Ga-NOTA-MAL-Cys-MZHER2:342. ADVANCES IN KNOWLEDGE: The research investigated the feasibility of a 68Ga labeled HER2 affibody modified with a hydrophilic linker for breast cancer PET imaging. Favorable outcomes showed that the probe might be valuable for determining HER2 status of the disease.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/metabolismo , Radioisótopos de Gálio/farmacocinética , Tomografia por Emissão de Pósitrons/métodos , Receptor ErbB-2/metabolismo , Proteínas Recombinantes de Fusão/farmacocinética , Animais , Neoplasias da Mama/patologia , Cromatografia Líquida de Alta Pressão , Estudos de Viabilidade , Feminino , Xenoenxertos , Humanos , Rim/diagnóstico por imagem , Rim/metabolismo , Células MCF-7 , Camundongos , Camundongos Nus , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos , Proteínas Recombinantes de Fusão/síntese química , Distribuição Tecidual
6.
Zhonghua Yi Xue Za Zhi ; 99(35): 2756-2760, 2019 Sep 17.
Artigo em Chinês | MEDLINE | ID: mdl-31550798

RESUMO

Objective: To analyze the diagnostic value of diffusion-weighted imaging (DWI) signal pattern in renal lesions with T(2)WI hypointensity. Methods: Retrospective analysis was performed on DWI imaging datasets of 135 renal lesions with hypointentsity on T(2)WI confirmed by surgery, biopsy, or follow-up in the First Medical Center of Chinese PLA General Hospital from February 2016 to February 2017.One hundred and thirty-five renal lesions,43 benign lesions(age from 28 to 70 years,mean age was 43.5 years, male 18 lesions and female 25 lesions) and 92 malignant lesions (age from 17 to 86 years, mean age was 54.1 years, male 62 lesions and female 30 lesions). DWI signal pattern was classified into six categories: homogeneously high signal, homogeneously low signal, heterogeneously high signal, high halo signal, high halo and nodular signal, and high nodular signal. The agreement between two observers were tested using kappa statistic. The statistical difference between DWI signal characteristics in benign and malignant lesions was analyzed with Chi-Square test. Diagnostic efficacy in differentiation of benign and malignant renal lesions using DWI signal pattern were calculated. Results: One hundred and thirty-five lesions were detected in 135 cases with T(2)WI hypointensity. There were 43 benign lesions and 92 malignant lesions. The agreement between two observers was very good (kappa value=0.878 6). In renal T(2)WI hypointensity lesions, the proportion of DWI homogeneous high signal, homogeneous low signal, heterogeneous high signal, high halo signal, high halo and nodular signal, high nodular signal was 4.7% (2/43), 25.6% (11/43), 30.2% (13/43), 18.6% (8/43), 11.6% (5/43), 9.3% (4/43), respectively. The proportion of malignant lesions was 10.9% (10/92), 0 (0/92), 17.4% (16/92), 13.0% (12/92), 56.5% (52/92) and 2.2% (2/92), respectively. The difference of high halo and nodules signal and homogeneous low signal was statistically significant (all P<0.01). The sensitivity, specificity, positive prediction value (PPV) and negative prediction value (NPV) of high halo and nodular signal for malignancy were 56.5% (52/92), 88.4%(38/43), 91.2% (52/57) and 48.7%(38/78), respectively and homogeneous low signal for benign lesions were 25.6% (11/43), 100.0% (92/92), 100.0% (11/11) and 74.2% (92/124), respectively. Conclusions: DWI signal features may facilitated the accurate diagnosis of renal lesions with T(2)WI hypointensity. Malignant lesions exhibit a higher propensity with high halo and nodular signal on DWI while benign lesions with homogeneous low signal.


Assuntos
Imagem de Difusão por Ressonância Magnética , Rim/diagnóstico por imagem , Rim/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias Renais/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Sensibilidade e Especificidade , Adulto Jovem
8.
Am J Vet Res ; 80(9): 825-831, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31449446

RESUMO

OBJECTIVE: To assess effects of catheter diameter and injection rate of flush solution (saline [0.9% NaCl] solution) on renal contrast-enhanced ultrasonography (CEUS) with perfluorobutane in dogs. ANIMALS: 5 healthy Beagles. PROCEDURES: CEUS of the kidneys was performed by IV injection of contrast medium (0.0125 mL/kg) followed by injection of 5 mL of saline solution at rates of 1, 3, and 5 mL/s through a 20-gauge or 24-gauge catheter; thus, CEUS was repeated 3 times for each catheter diameter. Time-intensity curves were created for regions of interest drawn in the renal cortex and medulla. Repeatability was determined by calculating the coefficient of variation (CV). Statistical analysis was used to assess whether perfusion variables or CV of the perfusion variables was associated with catheter diameter or injection rate. RESULTS: Perfusion variables did not differ significantly between catheter diameters. Time to peak enhancement (TTP) in the renal cortex was affected by injection rate, and there were significantly lower values for TTP at higher injection rates. The CEUS variables with the lowest CVs among injection rates were TTP for the renal cortex; the CV for TTP of the renal cortex was the lowest at an injection rate of 5 mL/s. CONCLUSIONS AND CLINICAL RELEVANCE: Use of a 24-gauge catheter did not alter CEUS with perfluorobutane; therefore, such catheters could be used for CEUS of the kidneys of small dogs. Moreover, a rate of 5 mL/s is recommended for injection of flush solution to obtain greater accuracy for renal CEUS in Beagles.


Assuntos
Cateteres de Demora , Cães , Fluorcarbonetos/administração & dosagem , Rim/diagnóstico por imagem , Ultrassonografia/veterinária , Animais , Meios de Contraste/administração & dosagem , Feminino , Injeções Intravenosas , Rim/metabolismo , Masculino , Perfusão
9.
Am J Vet Res ; 80(8): 764-770, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31339766

RESUMO

OBJECTIVE: To determine whether previously described cutoffs for ultrasonographically determined kidney length-to-aorta diameter ratio (KL:Ao) for evaluation of kidney size in adult dogs are applicable to healthy dogs 1 to 18 months of age and to assess interobserver and intraobserver variability for ultrasonographic kidney and aorta measurements in these dogs grouped according to age. ANIMALS: 82 dogs. PROCEDURES: 41 university-owned dogs and 41 client- or staff-owned dogs of 3 age groups (approx 1, 6, and 12 to 18 months of age) underwent ultrasonographic examination by 3 observers. Kidney length, kidney width, and diameter of the aorta were measured by each observer 3 times, and KL:Ao and kidney length-to-body weight ratio were calculated for each dog. Measurements and calculated ratios for the 3 age groups were compared by statistical methods; interobserver and intraobserver variability were calculated. RESULTS: Mean kidney length, kidney width, and aorta diameter were smaller, and calculated KL:Ao and kidney length-to-body weight ratio were larger, for dogs of the 1-month age group than for dogs of the 6-month and 12 to 18-month age groups. There were significant interobserver differences for ultrasonographic measurements in all age groups; these were most frequent in the youngest group of dogs and affected KL:Ao for that group only. CONCLUSIONS AND CLINICAL RELEVANCE: Results revealed that 1-month-old dogs have larger kidneys relative to body weight and aorta diameter than do older dogs. Interobserver variability for the youngest group of dogs indicated limited usefulness of these measurements and related ratios for neonatal dogs in clinical practice. The KL:Ao values for dogs ≥ 6 months of age in this study were similar to values previously described for dogs > 12 months of age.


Assuntos
Aorta/diagnóstico por imagem , Cães/anatomia & histologia , Rim/diagnóstico por imagem , Ultrassonografia/veterinária , Animais , Aorta/anatomia & histologia , Rim/anatomia & histologia , Variações Dependentes do Observador , Tamanho do Órgão
11.
Clin Nucl Med ; 44(8): 648-649, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31274612

RESUMO

Findings of Tc-DTPA renal scintigraphy of a retroperitoneal malignant peripheral nerve sheath tumor are reported here. The patient was a 48-year-old woman who presented discomfort and intermittent dull pain in the left upper quadrant of the abdomen for approximately 3 weeks.


Assuntos
Rim/diagnóstico por imagem , Neurofibrossarcoma/diagnóstico por imagem , Neurofibrossarcoma/patologia , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/patologia , Pentetato de Tecnécio Tc 99m , Feminino , Humanos , Pessoa de Meia-Idade , Cintilografia
12.
Int Braz J Urol ; 45(5): 1022-1032, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31268642

RESUMO

PURPOSE: This hybrid retrospective and prospective study performed on 200 consecutive patients undergoing renal CTA, investigates the opacification of renal vasculature, radiation dose, and reader confidence. MATERIALS AND METHODS: 100 patients were assigned retrospectively to protocol A and the other 100 were allocated prospectively to protocol B. Both protocols implemented a contrast material and saline flow rate of 4.5 mL/sec. Protocol A utilized a 100 mL of low-osmolar nonionic IV contrast material (Ioversol 350 mg I/mL) while protocol B employed a patient-tailored contrast media formula using iso-osmolar non-ionic (Iodixanol 320 mg I/mL). RESULTS: Arterial opacification in the abdominal aorta and in the bilateral main proximal renal arteries demonstrated no statistical significance (p>0.05). Only the main distal renal artery of the left kidney in protocol B was statistically significant (p<0.046). In the venous circulation, the IVC demonstrated a significant reduction in opacification in protocol B (59.39 HU ± 19.39) compared to A (87.74 HU ± 34.06) (p<0.001). Mean CNR for protocol A (22.68 HU ± 13.72) was significantly higher than that of protocol B (14.75 HU ± 5.76 p<0.0001). Effective dose was significantly reduced in protocol B (2.46 ± 0.74 mSv) compared to A (3.07 ± 0.68 mSv) (p<0.001). Mean contrast media volume was reduced in protocol B (44.56 ± 14.32 mL) with lower iodine concentration. ROC analysis demonstrated significantly higher area under the ROC curve for protocol B (p<0.0001), with inter-reader agreement increasing from moderate to excellent in renal arterial visualization. CONCLUSION: Employing a patient-tailored contrast media injection protocol shows a significant refinement in the visualization of renal vasculature and reader confidence during renal CTA.


Assuntos
Angiografia por Tomografia Computadorizada/métodos , Meios de Contraste/administração & dosagem , Rim/irrigação sanguínea , Rim/diagnóstico por imagem , Adulto , Idoso , Angiografia por Tomografia Computadorizada/normas , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Curva ROC , Doses de Radiação , Valores de Referência , Artéria Renal/diagnóstico por imagem , Veias Renais/diagnóstico por imagem , Reprodutibilidade dos Testes , Estudos Retrospectivos , Ácidos Tri-Iodobenzoicos/administração & dosagem
13.
J Urol ; 202(6): 1263-1269, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31347954

RESUMO

PURPOSE: Urinary stone treatment has been strongly influenced by advances in technology. Nevertheless, the photonic characteristics of stones as the treatment target have been neglected. Monitoring fluorescence spectra is sufficient for automatic target differentiation and laser feedback control as previously described. We investigated the characteristics of fluorescence signals and the clinical practicability of real-time laser feedback control during lithotripsy. MATERIALS AND METHODS: Fluorescence excitation light was superimposed on a holmium laser beam into the treatment fiber. Spectra were recorded and signal amplitude changes were analyzed during increases in distance between the fiber tip and the stone to identify the optimal threshold level for stone recognition. Ho:YAG lithotripsy was performed under in vitro surgical conditions in porcine tissue while our feedback system autonomously controlled the laser impulse release during lithotripsy. The tissue was then endoscopically and macroscopically examined for laser induced lesions. RESULTS: Mean ± SD autofluorescence signal amplitudes from urinary stone samples varied between 142 ± 29 and 1,521 ± 152 ADU while tissue and endoscope coating emission was negligible. Signal amplitude decreased rapidly at distances larger than 1 to 2 mm. Clinically reliable threshold values for target recognition could be set to prevent laser pulse emission if the stone was out of range or urothelial tissue might be harmed by laser irradiation. We observed no incorrectly released laser pulse or injury to tissue during autonomously controlled holmium laser lithotripsy. CONCLUSIONS: Our laboratory study strengthens the evidence that tracking real-time autofluorescence spectra during endoscopic stone surgery via automatic feedback control of the laser impulse release may become a potentially useful clinical tool for surgeons who navigate in the upper urinary tract.


Assuntos
Litotripsia a Laser/métodos , Imagem Óptica/métodos , Cirurgia Assistida por Computador/métodos , Ureteroscopia/métodos , Cálculos Urinários/cirurgia , Animais , Modelos Animais de Doenças , Estudos de Viabilidade , Retroalimentação , Humanos , Rim/diagnóstico por imagem , Rim/cirurgia , Lasers de Estado Sólido , Litotripsia a Laser/instrumentação , Imagem Óptica/instrumentação , Reprodutibilidade dos Testes , Cirurgia Assistida por Computador/instrumentação , Suínos , Resultado do Tratamento , Ureteroscópios , Ureteroscopia/instrumentação , Cálculos Urinários/diagnóstico por imagem
14.
Clin Nucl Med ; 44(10): e574-e576, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31348078

RESUMO

An end-stage renal disease patient underwent renal transplantation 18 years back and was on triple immunosuppression for acute rejection. She presented with left-sided abdominal lump and underwent ultrasound and noncontrast CT scan, which revealed an exophytic mass lesion in atrophic left kidney (16.2 × 13.1 × 14 cm). Baseline F-FDG PET/CT revealed a large avid exophytic mass (SUVmax 23, 17 × 14 × 13) in atrophic left kidney, with multiple retroperitoneal lymphadenopathies and a suspicious lung nodule. She underwent left open radical nephrectomy. Follow-up PET/CT after 1 month revealed multiple soft tissue deposits in operative bed and other unusual metastatic sites.


Assuntos
Carcinoma de Células Renais/diagnóstico por imagem , Carcinoma de Células Renais/patologia , Fluordesoxiglucose F18 , Neoplasias Renais/diagnóstico por imagem , Neoplasias Renais/patologia , Transplante de Rim , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Carcinoma de Células Renais/terapia , Progressão da Doença , Feminino , Humanos , Rim/diagnóstico por imagem , Rim/patologia , Neoplasias Renais/terapia , Pessoa de Meia-Idade , Metástase Neoplásica
15.
Can Assoc Radiol J ; 70(3): 226-232, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31255393

RESUMO

In 2017, the Canadian Association of Radiologists issued a clinical practice guideline (CPG) regarding the use of gadolinium-based contrast agents (GBCAs) in patients with acute kidney injury (AKI), chronic kidney disease (CKD), or on dialysis due to mounting evidence indicating that nephrogenic systemic fibrosis (NSF) occurs with extreme rarity or not at all when using Group II GBCAs or the Group III GBCA gadoxetic acid (compared to first generation Group I linear GBCAs). One of the goals of the work group was to re-evaluate the CPG after 24 months to determine the effect of more liberal use of GBCA on reported cases of NSF in patients with AKI, CKD Stage 4 or 5 (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73 m2), or those that are dialysis-dependent. A comprehensive review of the literature was conducted by a subcommittee of the initial CPG panel between the dates of January 1, 2017-December 31, 2018 to identify new unconfounded cases of NSF linked to Group II or Group III GBCAs and an updated CPG developed. To our knowledge, when using a Group II or Group III GBCA between 2017-2018, only a single unconfounded case report of a fibrosing dermopathy has been reported in a patient who received gadobenate dimeglumine with Stage 2 CKD. No other unconfounded cases of NSF have been reported with Group II or III agents in during this timeframe. The subcommittee concluded that the main recommendations from the 2017 CPG should remain unaltered, but agreed that screening for renal disease in the outpatient setting is no longer justifiable, cost-effective or recommended. Patients on hemodialysis (HD) should, however, be identified prior to GBCA administration to arrange timely HD to optimize gadolinium clearance, although there remains no evidence that HD reduces the risk of NSF. When administering Group II or III GBCAs to patients with AKI, on dialysis or with severe CKD, informed consent relating to NSF is also no longer explicitly recommended.


Assuntos
Meios de Contraste , Gadolínio , Aumento da Imagem/métodos , Nefropatias/diagnóstico por imagem , Imagem por Ressonância Magnética , Canadá , Humanos , Rim/diagnóstico por imagem , Radiologistas , Sociedades Médicas
16.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 36(3): 371-378, 2019 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-31232538

RESUMO

This paper explored the feasibility of using ultrasonic Nakagami statistic parameter imaging to evaluate the thermal lesion induced by microwave ablation (MWA) in porcine models. In this paper, thermal lesions were induced in livers and kidneys in 5 swines using a clinical MWA system. During this treatment progress, ultrasonic radiofrequency (RF) data were collected. The dynamic changes of Nakagami parameter in the thermal lesion were calculated, and the ultrasonic B-mode images and Nakagami images were reconstructed simultaneously. The contrast-to-noise ratio (CNR) between the thermal lesion and the surrounding normal tissue was calculated over the MWA procedure. After MWA, a bright hyperechoic region appeared in the ultrasonic Nakagami image as an indicator of the thermal lesion and this bright spot enlarged with lesion development during MWA exposure. The mean value of Nakagami parameter in the liver and kidney increased from 0.78 and 0.79 before treatment to 0.91 and 0.92 after treatment, respectively. During MWA exposure, the mean values of CNR calculated from the Nakagami parameter increased from 0.49 to 1.13 in the porcine liver and increased from 0.51 to 0.85 in the kidney, which were both higher than those calculated from the B-mode images. This in vivo study on porcine models suggested that the ultrasonic Nakagami imaging may provide an alternative modality for monitoring MWA treatment.


Assuntos
Rim/diagnóstico por imagem , Fígado/diagnóstico por imagem , Micro-Ondas , Ablação por Radiofrequência , Ultrassonografia , Animais , Ondas de Rádio , Suínos
17.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 36(3): 511-514, 2019 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-31232557

RESUMO

Chronic kidney disease (CKD) is now recognized as a worldwide public health challenge, and the incidence rate and hospitalization rate have significantly increased in recent years. Without prompt diagnoses and effective treatment in the early renal function damage of CKD, the symptoms will continue to worsen and eventually develop into end-stage renal disease. Functional imaging techniques such as single photon emission computed tomography (SPECT), contrast-enhanced ultrasound (CEUS), computerized tomography perfusion (CTP), and magnetic resonance perfusion weighted imaging (MR-PWI) could be used to quantitatively analyze renal perfusion and renal filtration function. Their diagnostic values are increasingly evident and have become the research hotspot in evaluating renal function. The aim of this review is to briefly evaluate the research and application advances in the early renal function damage assessment of CKD, so as to raise the efficiency of clinical applications.


Assuntos
Insuficiência Renal Crônica/diagnóstico por imagem , Humanos , Rim/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Tomografia Computadorizada por Raios X , Ultrassonografia
18.
J Vet Med Sci ; 81(7): 1006-1011, 2019 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-31155548

RESUMO

Feline polycystic kidney disease (PKD), an inherited autosomal dominant disease, has been reported to occur mostly in Persian or Persian related cats, and to be associated with a mutation from C to A at position 10063 in exon 29 of the feline PKD1 gene (PKD1 mutation). Many clinical cases have been recognized in Japan, but the mutation rate in cats has not been reported. The objective of this study was to determine epidemiological characteristics and clinical features in cats with the PKD1 mutation. Referring veterinarians sent blood samples of 377 cats for the PKD1 gene evaluation. The blood samples were from 159 cats with renal cysts confirmed by ultrasonography, 60 cats without renal cysts, and 158 cats that did not undergo ultrasonography. In total, 150 cats carried the PKD1 mutation and the signalment, site and number of renal cysts, and results of blood test were evaluated in cats with the PKD1 mutation. The breeds with the highest rate of the PKD1 mutation were Persian (46%), Scottish Fold (54%) and American Shorthair cats (47%). However, mixed breed cats also showed high rates of the PKD1 mutation. Of cats with the mutation, the incidence of high plasma creatinine (≥1.6 mg/dl) was greater in cats ≥3 years old, although a few cats ≥9 years of age had low plasma creatinine (<1.6 mg/dl). The coincidence of renal and hepatic cysts was 12.6%, with the high prevalence in Persian cats (31%).


Assuntos
Doenças do Gato/epidemiologia , Doenças do Gato/genética , Predisposição Genética para Doença , Rim Policístico Autossômico Dominante/veterinária , Animais , Gatos , Creatinina/sangue , Feminino , Japão , Rim/diagnóstico por imagem , Masculino , Mutação , Rim Policístico Autossômico Dominante/epidemiologia , Rim Policístico Autossômico Dominante/genética , Canais de Cátion TRPP/genética , Ultrassonografia/veterinária
20.
Gen Physiol Biophys ; 38(3): 191-204, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31184306

RESUMO

This study reports a non-invasive magnetic resonance imaging (MRI) of kidney dysfunction in mice, based on the induction of redox-imbalance and oxidative stress in the renal tissues, using mito-TEMPO as redox-sensitive contrast probe. Kidney dysfunction was triggered by hypercholesterolemia. The mice were divided in three groups: (i) on normal diet (ND); (ii) on cholesterol diet (CD); (iii) on cholesterol plus cholestyramine diet (CC). After 15 weeks feeding, the mice were subjected to the following analyses: plasma cholesterol levels; serum test for renal functionality; nitroxide-enhanced MRI of tissue redox-status in vivo; histochemical staining of tissue section to visualize renal damage; evaluation of total antioxidant capacity and oxidative stress on isolated tissue specimens. MRI signal of mito-TEMPO in the kidney was characterized by: high intensity and long life-time in CD mice, indicating a high oxidative capacity of renal tissues; poor intensity and short life-time in ND mice, indicating a high reducing capacity; moderate intensity and relatively short life-time in CC mice, indicating a protective effect of lipid-lowering drug. The data were confirmed on isolated tissue specimens, using conventional tests. They suggest that hypercholesterolemia induces redox-imbalance in kidney and this process could be visualized using MRI and mito-TEMPO as a redox-sensitive contrast.


Assuntos
Meios de Contraste , Rim/diagnóstico por imagem , Rim/fisiopatologia , Imagem por Ressonância Magnética/métodos , Compostos Organofosforados , Estresse Oxidativo , Piperidinas , Animais , Camundongos , Oxirredução
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