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1.
Zootaxa ; 4772(1): zootaxa.4772.1.2, 2020 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-33055623

RESUMO

Mosquitoes (Diptera: Culicidae) are insects capable of transmitting various disease agents. They have a wide geographical range, with a higher diversity and distribution in the tropical and subtropical regions. In Romania, data on mosquito distribution are available mostly from the older literature and published in local journals; hence, it is inaccessible to the international scientific community. The aim of this review was to gather all the published data on mosquitoes in Romania by performing a comprehensive literature search, to create a publicly available georeferenced database for the distribution of mosquitoes and generate distribution maps to identify gaps in the knowledge of mosquito diversity and distribution in the country. The resultant database includes 1,509 unique records for 51 mosquito species representing seven genera: Aedes, Anopheles, Culex, Culiseta, Coquillettidia, Orthopodomyia and Uranotaenia. Knowledge of mosquito distributions is important for understanding the risks of mosquito-borne pathogens present in Romania, a country with high endemicity for various diseases, such as West Nile fever and dirofilariasis. The database also revealed important knowledge gaps, including the lack of data for the Carpathian Arch and the central part of the historical regions of Moldova and Oltenia. The gaps become more evident, as the presence and diversity of the vectors have not been studied in many areas where diseases caused by mosquito-borne pathogens are present. In conclusion, despite the numerous georeferenced records, large areas of Romania remain unexplored for the mosquito species composition, abundance and phenology. This review is a "call for action" for implementing active surveillance in the country.


Assuntos
Anopheles , Culex , Animais , Mosquitos Vetores , Romênia
2.
Zootaxa ; 4802(3): zootaxa.4802.3.4, 2020 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-33056044

RESUMO

Up to the present, the genus Archiboreoiulus included only two species: A. sollaudi from France and A. pallidus with a wide European distribution range. Here we describe a previously unknown species of the genus Archiboreoiulus, A. serbansarbui, collected from the mesothermal sulfurous Movile Cave, Mangalia, Romania, harboring a rich and diverse troglobitic community.


Assuntos
Artrópodes , Cavernas , Animais , Filogenia , Romênia
3.
Euro Surveill ; 25(39)2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33006300

RESUMO

We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.


Assuntos
Betacoronavirus/genética , Técnicas de Laboratório Clínico , Infecções por Coronavirus/diagnóstico , Nucleoproteínas/genética , Pandemias , Pneumonia Viral/diagnóstico , Mutação Puntual , Polimorfismo de Nucleotídeo Único , RNA Viral/genética , Reação em Cadeia da Polimerase em Tempo Real , Proteínas Virais/genética , Sequência de Bases , Betacoronavirus/isolamento & purificação , Técnicas de Laboratório Clínico/métodos , Busca de Comunicante , Infecções por Coronavirus/virologia , Primers do DNA , Erros de Diagnóstico , Reações Falso-Negativas , Feminino , Genes Virais , Humanos , Pessoa de Meia-Idade , Nasofaringe/virologia , Nucleoproteínas/análise , Filogenia , Pneumonia Viral/virologia , Reação em Cadeia da Polimerase em Tempo Real/métodos , Romênia , Doença Relacionada a Viagens , Proteínas Virais/análise
4.
Artigo em Inglês | MEDLINE | ID: mdl-33086508

RESUMO

(1) Background: The COVID-19 pandemic and the imposition of strict but necessary measures to prevent the spread of the new coronavirus have been, and still are, major stress factors for adults, children, and adolescents. Stress harms human health as it creates free radicals in the human body. According to various recent studies, volatile oils from various aromatic plants have a high content of antioxidants and antimicrobial compounds. An external supply of antioxidants is required to destroy these free radicals. The main purpose of this paper is to create a yoghurt with high antioxidant capacity, using only raw materials from Romania; (2) Methods: The bioactive components used to enrich the cow milk yoghurt were extracted as volatile oils out of four aromatic plants: basil, mint, lavender and fennel. Initially, the compounds were extracted to determine the antioxidant capacity, and subsequently, the antioxidant activity of the yoghurt was determined. The 2,2-diphenyl-1-picrylhy-drazyl (DPPH) method was used to determine the antioxidant activity; (3) Results: The results show that cow milk yoghurt enhanced with volatile oils of basil, lavender, mint and fennel, encapsulated in sodium alginate has an antioxidant and antimicrobial effect as a staple food with multiple effects in increasing the body's immunity. The antioxidant activity proved to be considerably higher than the control sample. The highest antioxidant activity was obtained on the first day of the analysis, decreasing onwards to measurements taken on days 10 and 20. The cow milk yoghurt enriched with volatile basil oil obtained the best results; (4) Conclusions: The paper shows that yoghurts with a high antioxidant capacity were obtained, using only raw materials from Romania. A healthy diet, compliance with safety conditions and finding appropriate and safe methods to increase the body's immunity is a good alternative to a major transition through harder times, such as pandemics. The creation of food products that include natural antioxidant compounds combines both the current great possibility of developing food production in Romania and the prevention and reduction of the effects caused by pandemic stress in the human body.


Assuntos
Antioxidantes/uso terapêutico , Sistema Imunitário , Óleos Vegetais/uso terapêutico , Iogurte , Alginatos , Animais , Betacoronavirus , Infecções por Coronavirus , Humanos , Pandemias , Pneumonia Viral , Romênia , Estresse Psicológico/imunologia
5.
Medicine (Baltimore) ; 99(35): e21895, 2020 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-32871920

RESUMO

MicroRNAs (miRNAs) refers to a small, short non-coding RNA of endogenous class. They have shown to have an increasingly altered expression in many types of cancer, including colorectal cancer (CRC).In the present study, miRNA TaqManMGB and qRT-PCR was used to quantify the expression and clinical significance of 3 mature human miRNA in 82 pairs of colorectal adenocarcinoma tissues and normal adjacent tissue samples (NATS) collected from patients of the south-east part of Romania. Differences between CRC and NATS were analyzed using Wilcoxon test, while correlations between miRNAs expression levels and clinicopathological features were examined using non-parametric tests. In addition, the ability of selected miRNAs to function as biomarkers and, as potential indicators in CRC prognosis was also examined.When the miRNA expression was compared in CRC related NATS, miR-143, and miR-145 were significantly underexpressed (4.99 ±â€Š-1.02 vs -5.66 ±â€Š-1.66, P < .001; -4.85 ±â€Š-0.59 vs -9.27 ±â€Š-1.51, P < .001, respectively), while the pattern of miR-92a was significantly overexpressed (-5.55 ±â€Š-2.83 vs -4.92 ±â€Š-2.44, P < .001). Moreover, the expression levels of selected miRNAs were identified to be correlated with gradual increases in fold change expression with the depth of tumor invasion, lymph node invasion, and maximal increases with distant metastasis. Furthermore, the receiver operating characteristic analysis demonstrated that potential diagnostic of miR-143, miR-145, and miR-92a in discriminating CRC from NATS, with the area under the curve of 0.74, 0.85, and 0.84 respectively. The Kaplan-Meier and the log-rank test showed that a high level of miR-92a and low levels of miR-143 and miR-145 predicted poor survival rate in our cohorts.In conclusion, we can summarize that miR-145 and miR-143 are decreased, while miR-92 is increased in CRC compared to NATS, and associated with different stages of CRC pathogenesis. Thus, the expression of selected miRNAs can represent potential diagnostic and prognostic tools in patients with CRC from Romania.


Assuntos
Adenocarcinoma/diagnóstico , Biomarcadores Tumorais/genética , Neoplasias Colorretais/diagnóstico , MicroRNAs/genética , Adenocarcinoma/genética , Adenocarcinoma/patologia , Idoso , Área Sob a Curva , Neoplasias Colorretais/genética , Neoplasias Colorretais/patologia , Feminino , Expressão Gênica , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Prognóstico , Curva ROC , Romênia , Transcriptoma
6.
Chirurgia (Bucur) ; 115(4): 448-457, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32876018

RESUMO

Background: In Romania, colorectal cancer does not benefit yet from a national screening program. In order to decrease the harm and burden of colorectal cancer (CRC), opportunistic programs relying on endoscopy has been adopted by each centre according to its capacity. A colorectal cancer (CRC) screening programme based on faecal immunochemical test (FIT) was launched at Ponderas Academic Hospital (PAH) in 2019. Aim: The present study analyses the outcomes after the first 1500 tests in the PAH-FIT-CRC Screening Program. We have also aimed to compare the efficiency of the FIT testing program with the screening colonoscopies performed in our Center, withing the same time interval (2019). Methods: The test was recommended in asymptomatic patients over 45 years, and it was followed by a colonoscopy when the test results were positive. Furthermore, we performed a retrospective observational study gathering data from all the consecutive patients prospectively included in the respective databases of our hospital, comparing the efficacy of the two colorectal cancer screening methods (FIT versus colonoscopy). Results: Between 01.01.2019 and 01.01.2020, 1524 screening colonoscopies were performed, and the resulting data were compared with those obtained in the FIT group (1500 FIT tests freely distributed). In the screening colonoscopy group, the polyp detection rate was 38.98% and 22 (1.44%) adenocarcinomas were identified. In the FIT group, the FIT uptake rate was 71% with a positivity rate of 21.7%. The colonoscopy compliance rate for positive FIT patients was 29.4%, with only 2 adenocarcinomas detected. Conclusions: Following data analysis, the need for improvement of uptake rate and colonoscopy compliance rate was suggested, due to the lower acceptance of FIT tests and colonoscopies, especially among men. Moreover, special efforts should be made in order to improve quality indicators for screening colonoscopies (especially adenoma detection rate) with the purpose of decreasing interval CRC.


Assuntos
Adenocarcinoma/diagnóstico , Pólipos Adenomatosos/diagnóstico , Neoplasias Colorretais/diagnóstico , Detecção Precoce de Câncer/métodos , Fezes , Colonoscopia , Fezes/química , Humanos , Masculino , Programas de Rastreamento/métodos , Estudos Retrospectivos , Romênia , Resultado do Tratamento
7.
Chirurgia (Bucur) ; 115(4): 486-492, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32876022

RESUMO

Background: Burns are common reasons for emergency department presentations. While extensive or special burns require treatment in a specialized center, the majority are amenable to ambulatory treatment or hospitalization in a surgical ward. Romania has a national data collecting mechanism regarding all hospitalized patients, but there are no available statistics concerning non-hospitalized burn cases. This study aims to explore the amplitude of burn trauma by analyzing data from an Emergency Department at a major Romanian regional trauma center. Methods: This is a retrospective single-center 1-year study of all burn-related emergency department presentations at the trauma referral center for Romania's North-East region, in 2015. Included in the study were all cases of burns, indiscriminate of their etiology. Results: A total of 355 burn cases were analyzed. The average monthly number of cases was 29.58, with a maximum of 54 and a minimum of 18. There were 206 males and 149 females and 57.7% urban residents. Only 134 cases have been hospitalized during this period. Conclusions: Almost two-thirds of cases have not been hospitalized, thus missing from national statistics. Precise epidemiological data is paramount for a successful national burn management strategy. Creation of a national burn registry is suggested.


Assuntos
Queimaduras/epidemiologia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Assistência Ambulatorial/estatística & dados numéricos , Unidades de Queimados/estatística & dados numéricos , Queimaduras/terapia , Feminino , Humanos , Tempo de Internação , Masculino , Estudos Retrospectivos , Romênia/epidemiologia , Resultado do Tratamento
8.
Medicine (Baltimore) ; 99(33): e21284, 2020 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-32871986

RESUMO

RATIONALE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which quickly spread throughout the world, has been putting medical workers all over the world in difficulty because of the high number of cases combined with the lack of information about the disease. Although pediatric cases are rare, the group age under 12 months has been in general more susceptible to develop severe forms of the disease compared with the patients in the age interval of 1 to 18 years. PATIENT CONCERNS: Three newborns have been tested positive for SARS-CoV-2 infection. One of them presented bilateral decreased air entry, while the other 2 had no respiratory symptomatology. All 3 developed diaper erythema and oral candidiasis. DIAGNOSIS: For building up the report, newborns that were positive for coronavirus disease 2019 (COVID-19) infection were included in the case series. The chest X-ray of the symptomatic patient revealed a medium degree of hilar parenchymal infiltration and a slight infiltration of the visceral pleura. INTERVENTIONS: The patients were admitted in our isolated neonatology ward. All of them received antifungal treatment for the oral candidiasis and topic cream for diaper erythema. The symptomatic patient also received prophylactic antibiotherapy, human immunoglobulins, aminophylline, and parenteral nutrition. OUTCOMES: All 3 neonates were discharged after 2 consecutive negative tests for SARS-CoV-2. Patients 1 and 2 fully recovered, whereas the condition of patient 3 improved. LESSONS: Even if there are only a few reported cases of neonates infected with COVID-19 and most of them present mild manifestations, newborns need a more careful insight because of the nonspecific symptomatology.


Assuntos
Betacoronavirus , Candidíase Bucal/virologia , Infecções por Coronavirus/complicações , Eritema/virologia , Pneumonia Viral/complicações , Dermatopatias Virais/patologia , Adolescente , Candidíase Bucal/patologia , Criança , Pré-Escolar , Infecções por Coronavirus/virologia , Eritema/patologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pandemias , Pneumonia Viral/virologia , Romênia/epidemiologia , Dermatopatias Virais/virologia
9.
Artigo em Inglês | MEDLINE | ID: mdl-32942766

RESUMO

This paper examines the linkages in financial markets during coronavirus disease 2019 (COVID-19) pandemic outbreak. For this purpose, daily stock market returns were used over the period of December 31, 2019-April 20, 2020 for the following economies: USA, Spain, Italy, France, Germany, UK, China, and Romania. The study applied the autoregressive distributed lag (ARDL) model to explore whether the Romanian stock market is impacted by the crisis generated by novel coronavirus. Granger causality was employed to investigate the causalities among COVID-19 and stock market returns, as well as between pandemic measures and several commodities. The outcomes of the ARDL approach failed to find evidence towards the impact of Chinese COVID-19 records on the Romanian financial market, neither in the short-term, nor in the long-term. On the other hand, our quantitative approach reveals a negative effect of the new deaths' cases from Italy on the 10-year Romanian bond yield both in the short-run and long-run. The econometric research provide evidence that Romanian 10-year government bond is more sensitive to the news related to COVID-19 than the index of the Bucharest Stock Exchange. Granger causality analysis reveals causal associations between selected stock market returns and Philadelphia Gold/Silver Index.


Assuntos
Comércio/economia , Infecções por Coronavirus/economia , Desenvolvimento Econômico , Pandemias/economia , Pneumonia Viral/economia , Betacoronavirus , China , França , Alemanha , Humanos , Itália , Romênia , Espanha , Reino Unido , Estados Unidos
10.
PLoS One ; 15(8): e0237510, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32810155

RESUMO

Periodontitis is a highly prevalent condition leading to a continuous destruction of tooth-supporting tissues. It increases the risk for various systemic diseases and adverse pregnancy outcomes. Therefore, screening for periodontitis is important. Screening measures can range from self-reported symptoms to clinical full-mouth periodontal examination. The hypothesis of our study was that self-reported parameters and clinical definition perform equally well in identifying periodontitis patients. The aim of this study was to develop, validate its internal consistency, and evaluate a self-reported instrument against periodontal clinical evaluation for diagnosis of periodontitis in a group of postpartum women, as well as to describe their periodontal status and the risk factors associated with periodontal disease. A cross-sectional study on postpartum women was conducted in a tertiary university hospital, from April 2018 to March 2019. Sociodemographic and behavioral data, periodontal clinical parameters, and self-reported periodontal perception were collected. A 16-item questionnaire was developed to obtain information about perceived periodontal alterations and oral hygiene habits. The utility of the questionnaire was tested against a periodontal diagnosis based on a full-mouth periodontal examination. The questionnaire was applied in 215 postpartum women aged 29.16±5.54 years (mean age (y) ± standard deviation) having the following periodontal status: 16 individuals without periodontal disease (7.44%), 32 individuals with gingivitis (14.88%), 19 individuals with mild periodontitis (8.84%), 132 individuals with moderate periodontitis (61.39%), and 16 individuals with severe periodontitis (7.44%). A significant association was observed between oral hygiene score, smoking status, and periodontal conditions (p<0.05). A significant association between the self-reported items related to "gum swelling", "halitosis", "previous periodontal diagnosis" and "previous periodontal treatment" with clinical periodontitis have been identified (p<0.05). Using self-reported questionnaires for detection of periodontal disease was ineffective in our studied population, since self-reported parameters and clinical definition do not appear to perform equally in identifying periodontitis cases. Clinical periodontal examination remains the gold standard for screening. Periodontitis was frequent in our group and the severity was significantly associated with the oral hygiene score and smoking. These results underline the necessity for periodontal clinical examination during pregnancy.


Assuntos
Doenças Periodontais/epidemiologia , Doenças Periodontais/etiologia , Transtornos Puerperais/epidemiologia , Transtornos Puerperais/etiologia , Autorrelato , Adolescente , Adulto , Estudos Transversais , Europa Oriental/epidemiologia , Feminino , Gengivite/epidemiologia , Gengivite/etiologia , Halitose/epidemiologia , Halitose/etiologia , Humanos , Higiene Bucal/estatística & dados numéricos , Periodontite/epidemiologia , Periodontite/etiologia , Período Pós-Parto , Gravidez , Prevalência , Fatores de Risco , Romênia/epidemiologia , Autorrelato/estatística & dados numéricos , Inquéritos e Questionários , Adulto Jovem
11.
Sci Total Environ ; 745: 141170, 2020 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-32758733

RESUMO

The study examines the association between exposure to sub-micrometric Particulate Matter (PM1) and allergic response in a group of sensitive young children (age: 2-10 years) from Ploiesti city, Romania. The city is the only urban agglomeration in Europe surrounded by four oil refineries. A panel study was conducted by collecting medical information from children with respiratory illnesses and atopy (n = 135). Hot Spot Analysis revealed the areas of the city that are susceptible to high levels of PM1. We found a close interaction between exposure to PM1 outdoor concentrations and various physiological changes and clinical symptoms in children including triggering of allergic reactions, rhinitis, alteration of lung function, upper and lower respiratory tract symptoms, and bronchial asthma. During the 2-year study period, the incidence of hospitalizations was 40.7%. Strong correlations (p < 0.001) were observed between the PM1 exposure and hospitalizations, and exposure and Immunoglobulin E (IgE). PM1 exposure was also correlated with eosinophils (p < 0.05). Another positive correlation was observed between hospitalizations and IgE levels (p < 0.05). The mean results of tested indicators were as follows: wheezing (5.3, 95% CI (1.4-1.8); Coeff. of var. (CV) = 30%), IgE (382, 95% CI (349-445); CV = 102%), and EO% (5.3, 95% CI (3.3-4.2); CV = 69.5%). We can conclude that exposure to PM1 influenced the frequency of wheezing episodes, increased hospitalizations, and the levels of allergic blood indicators in children, especially in infants and pre-schoolers. CAPSULE: Exposure to sub-micrometric particles (PM1) influences the frequency of wheezing episodes, hospitalizations, and the levels of allergic blood indicators in children, especially in infants and pre-schoolers.


Assuntos
Hipersensibilidade , Material Particulado/efeitos adversos , Material Particulado/análise , Criança , Pré-Escolar , Cidades/epidemiologia , Europa (Continente) , Humanos , Lactente , Sons Respiratórios/etiologia , Romênia/epidemiologia
12.
PLoS One ; 15(8): e0237923, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32817661

RESUMO

We are living nowadays in a social paradigm characterized by a high degree of fluidity. From professional career to leisure, from family patterns to neighborhood relationships, from cultural consumption to domestic technology, almost all the components of social reality have changed during recent decades. A given couple's experience is not insulated from these dynamics, or at least from the pressure that new trends constantly put on it. How can functional relationships be preserved in a continuously changing world? What possibilities are there for couples to sustain viable relationships in the face of all the waves of change, involving as they do new content, new rules, and, in many cases, new values? This paper sets out to analyze how the main factors related to marital life interact and what their impact is on individual satisfaction in the dyadic experience. To this end we planned and applied a sociological survey to a national sample (N = 455 participants, error limit 4.7) using a questionnaire focusing on an evaluation of dyadic life experience that included the Dyadic Adjustment Scale (DAS). The major finding is that more liberal sexual attitudes and people's high view of the importance of money are the strongest predictors of a low-quality dyadic experience. The patterns observed also raise the possibility that positive perception of the parental model may serve to compensate for a couple's relatively shorter period of marital experience.


Assuntos
Adaptação Psicológica , Relações Interpessoais , Casamento/psicologia , Satisfação Pessoal , Adulto , Pré-Escolar , Família/psicologia , Feminino , Humanos , Atividades de Lazer/psicologia , Estudos Longitudinais , Masculino , Casamento/estatística & dados numéricos , Pessoa de Meia-Idade , Qualidade de Vida/psicologia , Religião e Psicologia , Romênia/epidemiologia , Sociologia/tendências
13.
J Med Life ; 13(2): 125-131, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32742502

RESUMO

Intracerebral hemorrhage is a significant public health problem, as it is a disease associated with overwhelming mortality and disability. We performed a retrospective feasibility study of patients admitted with acute intracerebral hemorrhage in our department for four months. Our aims were to identify peculiarities of the risk factors, demographic and clinical characteristics of intracerebral hemorrhage patients from our population, to estimate a feasible recruitment rate for a larger prospective study of patients with intracerebral hemorrhage and to analyze and correct potential drawbacks in the methodology of a more extensive prospective study of patients with intracerebral hemorrhage hospitalized in our department. During the study period, we admitted 53 patients with intracerebral hemorrhage in our department. The mean age of the patients was 69.1 years, and 53% were men. Arterial hypertension was the most common etiologic factor leading to intracerebral hemorrhage. 50.01% of patients died during hospitalization, 31.19% were discharged with significant disability, and 18.8% had a favorable short-term outcome. Higher hematoma volumes, male sex, deep location of the hemorrhage, and age between 51 and 60 years were factors associated with an unfavorable short-term outcome.


Assuntos
Hemorragia Cerebral/terapia , Distribuição por Idade , Idoso , Hemorragia Cerebral/etiologia , Hemorragia Cerebral/mortalidade , Estudos de Viabilidade , Feminino , Hematoma/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Romênia , Resultado do Tratamento
14.
J Med Life ; 13(2): 156-159, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32742507

RESUMO

Remote ischemic conditioning represents an intervention based on blood flow reduction applied at a distance from the lesion. The mechanism is supposed to elicit neurovascular protection, anti-inflammatory action, reduced excitotoxicity and metabolic protection. This study aims to explore the efficiency and safety of remote ischemic conditioning during the first five days following in patients who are ineligible for reperfusion treatment (intravenous thrombolysis or/and mechanical thrombectomy). We hypothesized that this intervention would reduce the infarct size (neuroprotection in the reperfusion window) and improve functional recovery. We aim to conduct a double-blind controlled trial, multicenter in two hospitals in Romania. Two hundred patients with acute ischemic stroke randomly divided into an experimental group and a control group will be included. The subjects in the experimental group will be subjected to remote ischemic conditioning twice daily with a maximum of 180 mmHg for 5 days, and a guideline- based treatment as well. The subjects in the control group will receive cuff inflation to 30 mmHg, which will induce sham preconditioning. The primary outcome measure will be radiological - the difference between baseline brain infarct volume and the volume at 180 days in the experimental group versus the control group. The second outcome considers clinical scores such as NIHSS, mRS, IADL, ADL, MOCA, PHQ-9 at baseline, 90 and 180 days; tolerance and side effects of remote ischemic conditioning; the reccurence of stroke or other vascular events at 180 days; incidence of stroke-associated comorbidities and the proportion of death of any cause within 180 days.


Assuntos
Isquemia Encefálica/terapia , Precondicionamento Isquêmico , Acidente Vascular Cerebral/terapia , Método Duplo-Cego , Humanos , Romênia , Resultado do Tratamento
15.
Rom J Morphol Embryol ; 61(1): 209-218, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32747912

RESUMO

We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.


Assuntos
Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/virologia , Pulmão/virologia , Pneumonia Viral/fisiopatologia , Pneumonia Viral/virologia , Adulto , Autopsia , Betacoronavirus , Técnicas de Laboratório Clínico , Infecções por Coronavirus/diagnóstico , Feminino , Humanos , Rim/patologia , Fígado/patologia , Pulmão/patologia , Miocárdio/patologia , Pâncreas/patologia , Pandemias , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Romênia , Trombose/patologia , Trombose/virologia
16.
Artigo em Inglês | MEDLINE | ID: mdl-32731593

RESUMO

This paper provides a rapid assessment method of potentially infectious waste flow related to the coronavirus disease (COVID-19) pandemic in Romania focusing on the emergency state (from 16 March to 14 May 2020) where a national lockdown was in force with restrictive and social distancing measures concerning population mobility and economic activities. Medical and municipal waste management systems are critical services in combating the virus spread in the community. This assessment is useful due to poor available data of medical waste flow in environmental reports and it covers COVID-19 patients, quarantined, and self-isolated persons as the main potential infectious waste sources. The proposed model estimates that COVID-19 related waste flow is 4312 t at the national level from 25 February to 15 June of which 2633 t in the emergency state period. This assessment is correlated with deficiencies of medical and municipal waste management systems in Romania before the COVID-19 pandemic as stress factors of public health and environment. This study points out the main challenges of waste operators and reveals some best practices during this pandemic crisis. Based on the results and discussion section, several recommendations are proposed to COVID-19 waste-related issues and points out the crucial role of the reliable medical and municipal waste database in managing such biologic hazards at national and EU levels. Monitoring of COVID-19 waste flow through such models are important for decision-makers, particularly in low and middle-income countries which are facing waste management deficiencies and gaps in waste statistics, to reduce other contamination risks or related environmental threats.


Assuntos
Betacoronavirus/isolamento & purificação , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Infecções por Coronavirus/virologia , Serviço Hospitalar de Emergência , Humanos , Pandemias , Pneumonia Viral/virologia , Saúde Pública , Quarentena , Romênia/epidemiologia , Gerenciamento de Resíduos
17.
Artigo em Inglês | MEDLINE | ID: mdl-32751368

RESUMO

The present paper intends to address the impact of COVID-19 crisis upon the consumer buying behavior of fresh vegetables directly from local producers as observed 30 days later, after enforcing the state of emergency in Romania within a well-defined area, namely, the quarantined area of Suceava. The study relies on the interpretation of answers received from the quarantined area (N = 257) to a questionnaire applied online nationwide. The starting point of this paper is the analysis of the sociodemographic factors on the purchasing decision of fresh vegetables directly from local producers before declaring the state of emergency in Romania (16 March 2020). Further research has been conducted by interpreting the changes triggered by the COVID-19 crisis on the purchasing intention of such products before and after the end of the respective crisis. The aim of this scientific investigation relies on identifying the methods by which these behavioral changes can influence the digital transformation of short food supply chains.


Assuntos
Betacoronavirus/isolamento & purificação , Comportamento do Consumidor , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Quarentena , Verduras , Adulto , Infecções por Coronavirus/virologia , Feminino , Abastecimento de Alimentos , Humanos , Intenção , Masculino , Pandemias , Pneumonia Viral/virologia , Romênia/epidemiologia , Inquéritos e Questionários
18.
Medicine (Baltimore) ; 99(31): e21512, 2020 Jul 31.
Artigo em Inglês | MEDLINE | ID: mdl-32756188

RESUMO

RATIONALE: Syncope is described as the loss of consciousness and postural muscle tone with a short duration and fast onset. Micturition syncope can be caused by abnormal vasovagal response or by the dysfunction of the blood pressure regulating mechanism, which occurs before, during, or immediately after urination. PATIENT CONCERNS: We present 4 cases of COVID-19 hospitalized in the Department of Infectious Diseases of the Academic Emergency Hospital Sibiu, Romania, cases that presented micturition syncope. DIAGNOSES: During hospitalization, patients confirmed with SARS-Cov-2 infection using real time reverse transcriptase-polymerase chain reaction (RT-PCR) assay, presented micturition syncope in different stages of the infection (at the beginning and in the second week of evolution). INTERVENTIONS: Other causes of syncope such as adrenal insufficiency secondary to corticosteroids treatment, cardiac rhythm disorders, neurological impairment, dehydration, vasoactive medication, malignancies, pulmonary hypertension and coughing were excluded. The treatment of SARS-CoV-2 infection was performed following the local and national guidelines. OUTCOMES: The clinical course of all 4 patients diagnosed with COVID-19 and micturition syncope was favorable. To our knowledge, micturition syncope in COVID-19 patients has yet not been reported by other authors. LESSONS: To our knowledge, micturition syncope associated with the evolution of COVID-19, has yet not been reported by other authors.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Pneumonia Viral/complicações , Síncope/virologia , Idoso , Infecções por Coronavirus/virologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/virologia , Romênia/epidemiologia
19.
PLoS One ; 15(7): e0235079, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32614838

RESUMO

In times of water shortage, it becomes increasingly relevant for policymakers to understand the existing relationships between different types of water use, so as to encourage efficient water management. This article makes use of yearly data on agricultural, industrial, and household water use in the Balkan countries of Bulgaria, Romania, and Serbia. It does so to identify the potential interactions among these three categories of water use. Using a deterministic model based on differential equations, we provide an analysis of the interactions among these different sectors of water use for the period between 2008 and 2017. Results show that interactions among these different categories do not remain constant over periods of time, either across or within the countries analysed. We find that, for most countries, industrial and household water uses are more likely to be characterised by mutualism and competition, instead of a predator-prey relationship. Agricultural water use, on the other hand, takes on the role of predator against the other two.


Assuntos
Conservação dos Recursos Hídricos , Recursos Hídricos , Agricultura , Península Balcânica , Bulgária , Características da Família , Indústrias , Romênia , Sérvia , Recursos Hídricos/provisão & distribução , Abastecimento de Água
20.
Artigo em Inglês | MEDLINE | ID: mdl-32645962

RESUMO

The novel coronavirus disease, COVID-19, is a highly contagious infectious disease declared by the World Health Organization to be a pandemic and a global public health emergency. During outbreaks, health care workers are submitted to an enormous emotional burden as they must balance the fundamental "duty to treat" with their parallel duties to family and loved ones. The aims of our study were to evaluate disease perceptions, levels of stress, emotional distress, and coping strategies among medical staff (COVID-19 versus non-COVID-19 departments) in a tertiary pulmonology teaching hospital in the first month after the outbreak of COVID-19. One hundred and fifteen health care workers completed four validated questionnaires (the brief illness perception questionnaire, perceived stress scale, the profile of emotional distress emotional, and the cognitive coping evaluation questionnaire) that were afterwards interpreted by one psychologist. There was a high level of stress and psychological distress among health care workers in the first month after the pandemic outbreak. Interestingly, there were no differences between persons that worked in COVID-19 departments versus those working in non-COVID-19 departments. Disease perceptions and coping mechanisms were similar in the two groups. As coping mechanisms, refocusing on planning and positive reappraisal were used more than in the general population. There is no difference in disease perceptions, levels of stress, emotional distress, and coping strategies in medical staff handling COVID-19 patients versus those staff who were not handling COVID-19 patients in the first month after the pandemic outbreak.


Assuntos
Adaptação Psicológica , Infecções por Coronavirus/psicologia , Pessoal de Saúde/psicologia , Pneumonia Viral/psicologia , Angústia Psicológica , Estresse Psicológico/epidemiologia , Adulto , Idoso , Betacoronavirus , Emoções , Feminino , Humanos , Masculino , Corpo Clínico , Pessoa de Meia-Idade , Pandemias , Romênia/epidemiologia , Inquéritos e Questionários
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