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1.
Prensa méd. argent ; 105(9 especial): 576-581, oct 2019.
Artigo em Inglês | LILACS, BINACIS | ID: biblio-1046621

RESUMO

This work is aimed at studying the problems of timely diagnostics and therapy of various forms of rosacea, identifying the factors that influence the compliance, prognosis, and quality of life of the patients, as well as the stages of combination therapy. The efficiency of rosacea therapy is determined by the timely identification of patients, as well as the clinical variety of the disease. Complex therapy of rosacea includes identification of the precipitating factors, basic skincare, and the use of systemic and local pathogenetic preparations. The "Gold Standard" of topical rosacea therapy is the antimicrobial and antiprotozoal drug called metronidazole. An important role in disease therapy is played by active cooperation between the doctor and the patient. Comprehensiveness, timeliness, and rationality of rosacea therapy are defined not only by the mechanisms of the disease development but also by aggravating factors, the need for basic care and photosensitivity of the patients


Assuntos
Transtornos de Fotossensibilidade , Retinoides/uso terapêutico , Isotretinoína/uso terapêutico , Cooperação do Paciente , Tacrolimo/uso terapêutico , Rosácea/diagnóstico , Terapia Combinada , Metronidazol/uso terapêutico
2.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(8): 637-641, oct. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-185501

RESUMO

El granuloma aséptico facial idiopático (GAFI) es una patología específica de la edad pediátrica caracterizada por la aparición de nódulos rojizos asintomáticos en la región facial. Su etiopatogenia es aún motivo de discusión, aunque la literatura actual orienta a que se encontraría dentro del espectro de la rosácea infantil. Tiene una evolución crónica pero benigna, y hay publicaciones que documentan la resolución espontánea de las lesiones en menos de un año. A pesar de no tener un tratamiento bien definido, se prefiere que sea conservador y se eviten las intervenciones agresivas


Idiopathic facial aseptic granuloma is a pediatric skin condition involving asymptomatic reddish nodules. The etiology and pathogenesis is still under discussion, although the literature tends to place this condition within the spectrum of childhood rosaceas. The clinical course is chronic but benign, and cases have been reported to resolve spontaneously in less than a year. Even though no well-defined treatment has emerged, a conservative approach that avoids aggressive therapies is preferred


Assuntos
Humanos , Criança , Granuloma/epidemiologia , Granuloma/etiologia , Dermatoses Faciais/diagnóstico por imagem , Granuloma/terapia , Dermoscopia/métodos , Dermatoses Faciais/fisiopatologia , Rosácea/diagnóstico , Face/patologia , Diagnóstico Diferencial , Pioderma/diagnóstico , Calázio/diagnóstico , Ultrassonografia Doppler em Cores
3.
J Drugs Dermatol ; 18(9): 888-894, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31524344

RESUMO

Rosacea is a common chronic inflammatory dermatosis with a variety of clinical manifestations. Rosacea primarily affects the central face, and includes papules, pustules, erythema, telangiectasias, perilesional redness, phymatous changes, and even ocular involvement. Symptoms may vary among different patients and even vary over time in an individual patient. Central facial redness affects many adults and can be an indicator of the chronic inflammatory disease rosacea. Rosacea is a clinical diagnosis based on the patient's history, physical examination, and exclusion of other disorders. It is under-diagnosed, particularly in individuals with skin of color. The goal of this article is to provide clinicians with the tools and understanding needed to correctly identify rosacea and differentiate it from other conditions that have overlapping signs and symptoms. J Drugs Dermatol. 2019;18(9):888-894


Assuntos
Rosácea/diagnóstico , Doença Crônica , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Rosácea/etiologia
4.
Ther Umsch ; 76(2): 84-91, 2019 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-31429390

RESUMO

Rosacea - manifestations and treatment options Abstract. Rosacea is a common dermatosis of the face with a prevalence of up to 22 %, according to the current literature. The known trigger factors include caffeine, alcohol, sunlight, hot and spicy foods, psychological stress, menstruation and extreme temperatures or temperature fluctuations. Diagnosis is most often clinical, however, due to the numerous differential diagnoses, performing a biopsy may be helpful in atypical manifestations. Depending on the symptoms, in addition to the avoidance of trigger factors, physical therapeutic options as well as topical and systemic drugs are available.


Assuntos
Rosácea , Humanos , Rosácea/diagnóstico , Rosácea/terapia
5.
J Drugs Dermatol ; 18(7): 608-612, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31329380

RESUMO

Rosacea is among the most common facial skin conditions diagnosed by dermatologists. Typical clinical features include erythema, flushing, telangiectasia, papules, and pustules distributed on the central face. While the prevalence of rosacea is highest among white populations of Northern European descent, recent reports have found that rosacea frequently occurs in people from a broad range of racial/ethnic backgrounds and skin types. When rosacea presents in darker skin types, the diagnosis is often more challenging due to masking of features by increased epidermal melanin. As such, under-diagnosis and underreporting may contribute to misconceptions about the prevalence of rosacea in populations with skin of color. Recognizing the unique presentations and complications associated with darker skin types is necessary to reduce the disparities in rosacea treatment, especially as the American population continues to become increasingly heterogeneous. Although rosacea is most common in middle-aged females, patients of other demographics may have more negative impacts on quality of life due to their disease. In this article, we review rosacea management with a focus on special patient groups: people with skin of color, and less common forms of rosacea, in order to diminish the physical and psychosocial burden of rosacea in all patient groups. Due to the variability inherent to rosacea, we advocate for an individualized, patient-centered approach to disease management.


Assuntos
Dermatologia/organização & administração , Carga Global da Doença , Assistência Centrada no Paciente/métodos , Rosácea/diagnóstico , Pigmentação da Pele , Adolescente , Adulto , Idade de Início , Dermatologistas/educação , Dermatologia/educação , Diagnóstico Diferencial , Medicina Baseada em Evidências/educação , Medicina Baseada em Evidências/organização & administração , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Relações Médico-Paciente , Guias de Prática Clínica como Assunto , Prevalência , Qualidade de Vida , Rosácea/epidemiologia , Rosácea/terapia , Adulto Jovem
6.
J Drugs Dermatol ; 18(7): 615, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31329381

RESUMO

Many cultures associate beauty with an even complexion. It has been shown in many reported references, the major cosmetic concern in patients of color is discoloration. This issue addresses discoloration of individuals of color and the use of a multitude of preparations that can blend the complexion. Authors in Asia, Sweden, France, and Brazil discuss the use of injectable deoxycholic acid in nonsubmental regions and hyaluronic acid for skin boosting, an off-label usage or procedures in the United States. Skin boosting improves hydration and the smoothness of the skin. Additionally, international methods of treating cosmetic patients with multiple modalities are discussed.


Assuntos
Ceratose Seborreica/terapia , Rosácea/terapia , Neoplasias Cutâneas/terapia , Pigmentação da Pele , Grupo com Ancestrais do Continente Africano , Grupo com Ancestrais do Continente Asiático , Técnicas Cosméticas , Feminino , Hispano-Americanos , Humanos , Ceratose Seborreica/diagnóstico , Fatores de Risco , Rosácea/diagnóstico , Pele/efeitos da radiação , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/etiologia , Luz Solar/efeitos adversos
7.
J Drugs Dermatol ; 18(6): 522, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31251544

RESUMO

Background: Anecdotal reports indicate the use of microfocused ultrasound with visualization (MFU-V) improves facial redness. Objective: The purpose of this pilot study was to assess the safety and effectiveness of MFU-V for improving the signs and symptoms of erythematotelangiectatic rosacea. Methods & Materials: Healthy adults with a clinical diagnosis of erythematotelangiectatic rosacea were enrolled (N=91). Eligible subjects had baseline Clinician Erythema Assessment (CEA) scores ≥3 and Patient Self-Assessment (PSA) of erythema scores ≥2. Subjects were randomized to receive one or two low-density MFU-V treatments or one or two high-density MFU-V treatments. Subjects were evaluated at 90, 180, and 365 days after treatment. The primary effectiveness endpoint was treatment success, defined as a 1-point change in CEA scores at 90 days post-treatment. Results: Across groups, 75 to 91.3% of subjects achieved treatment success at 90 days post-treatment. Notable adverse events include bruising (44%), tenderness/soreness (43%), and redness (35%). Treatment results were sustained, lasting up to 1 year. Subject satisfaction was high based on self-assessment questionnaires. Conclusion: The results of this study demonstrated that a single, high-density MFU-V treatment may be effective for treating erythematotelangiectatic rosacea. Based on these results, a large, randomized controlled study of single, high-density MFU-V treatment for erythematotelangiectatic rosacea is warranted. J Drugs Dermatol. 2019;18(6):522-531.


Assuntos
Eritema/terapia , Satisfação do Paciente , Rosácea/terapia , Terapia por Ultrassom/métodos , Adulto , Idoso , Eritema/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Rosácea/diagnóstico , Índice de Gravidade de Doença , Inquéritos e Questionários/estatística & dados numéricos , Resultado do Tratamento , Adulto Jovem
8.
Bol Med Hosp Infant Mex ; 76(2): 95-99, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30907384

RESUMO

Background: Rosacea is a chronic inflammatory skin condition that usually occurs in adults and rarely has been reported in children, although both subtypes share the same clinical characteristics. Case report: A 10-year-old female presented dermostosis on the face, affecting cheeks and nose, characterized by erythema, papules, pustules, scars of two years of evolution, as well as bilateral conjunctivitis, blepharitis and corneal opacity. She referred recurrent exacerbations and partial remission of cutaneous lesions and ocular symptoms related to sun exposure. She responded dramatically to systemic and topical antibiotics. Conclusions: Childhood rosacea should be distinguished from other most common erythematous facial disorders, such as acne, granulomatous perioral dermatitis, and sarcoidosis. The distribution of papulopustular facial lesions together with the presence of telangiectasia, flushing and the ocular findings allow the differentiation of rosacea from other facial eruptions.


Assuntos
Antibacterianos/administração & dosagem , Dermatoses Faciais/diagnóstico , Rosácea/diagnóstico , Criança , Dermatoses Faciais/tratamento farmacológico , Dermatoses Faciais/patologia , Feminino , Humanos , Rosácea/tratamento farmacológico , Rosácea/patologia , Resultado do Tratamento
9.
J Drugs Dermatol ; 18(3): s124-126, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30909359

RESUMO

Acne is a common disease among patients with Latin American ancestry. Its presentation is very similar to that in all skin types, but nodulocystic acne is more frequent in patients with oily and darker skin than in white Caucasians. Acne sequelae in patients with Latin American ancestry and with darker skin include postinflammatory hyperpigmentation (PIH) and atrophic and hypertrophic scars or keloids, with PIH being the most common complication affecting the quality of life of patients. Lately, more attention has been paid to rosacea in patients with darker skin. It has been seen that some of the patients, especially women, diagnosed with adult acne and who did not respond to treatment, were actually patients with rosacea. It is important to recognize the clinical characteristics of this disease in patients with darker skin in whom erythema and telangiectasia are difficult to observe. Here, we present the most relevant clinical characteristics of both diseases, as well as their treatment in patients with darker skin with Latin American ancestry. J Drugs Dermatol. 2019;18(3 Suppl):s124-126.


Assuntos
Acne Vulgar/terapia , Fármacos Dermatológicos/uso terapêutico , Hispano-Americanos , Rosácea/terapia , Acne Vulgar/complicações , Acne Vulgar/diagnóstico , Acne Vulgar/etnologia , Administração Cutânea , Administração Oral , Cicatriz Hipertrófica/etnologia , Cicatriz Hipertrófica/etiologia , Cicatriz Hipertrófica/prevenção & controle , Cosmecêuticos/uso terapêutico , Criocirurgia , Dermabrasão/métodos , Feminino , Humanos , Hiperpigmentação/etiologia , Hiperpigmentação/prevenção & controle , Terapia a Laser/métodos , Masculino , Qualidade de Vida , Rosácea/complicações , Rosácea/diagnóstico , Rosácea/etnologia , Fatores Sexuais , Pigmentação da Pele/efeitos dos fármacos , Pigmentação da Pele/fisiologia , Luz Solar/efeitos adversos , Protetores Solares/administração & dosagem , Estados Unidos
12.
Am J Ophthalmol ; 201: 72-81, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30703356

RESUMO

PURPOSE: To assess the role of nuclear factor kappa-B (NFKB) in cutaneous specimens of rosacea and unaffected tissue. METHODS: Immunohistochemical staining was performed for the activated, phosphorylated variant of NFKB (pNFKB) in eyelid specimens of rosacea (n = 12) and normal, healthy tissue (n = 12). The numbers of positively staining cells/40× microscopic field were counted across 5 consecutive fields. Additionally, quantitative Western blotting was carried out for pNFKB and NFKB in specimens of rosacea (n = 15) and normal controls (n = 14). Statistical comparisons were performed via a dedicated software package. RESULTS: The mean number of cells/40× microscopic field that stained positively for pNFKB was 18.4 (standard deviation = 15.3) for control patients and 39.3 (standard deviation = 16.9) for rosacea patients, and the difference between the 2 groups was statistically significant (P = .0024). On Western blotting, the mean ratios of pNFKB:NFKB for control and rosacea patients measured 0.58 (standard deviation = 0.81) and 3.11 (standard deviation = 3.53), respectively. The 2 groups were statistically significantly different (P = .0002). CONCLUSIONS: The activated form of NFKB is enriched in rosacea, indicating a role for this pathway in the pathogenesis of this disease. Interference with NFKB signaling may represent a novel therapy for rosacea as clinical agents become available. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.


Assuntos
Doenças Palpebrais/metabolismo , Pálpebras/metabolismo , NF-kappa B/metabolismo , Rosácea/metabolismo , Western Blotting , Doenças Palpebrais/diagnóstico , Doenças Palpebrais/etiologia , Doenças Palpebrais/terapia , Pálpebras/patologia , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Fosforilação , Rosácea/diagnóstico , Rosácea/etiologia , Rosácea/terapia
13.
J Drugs Dermatol ; 18(2): 141-146, 2019 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-30794364

RESUMO

Background: Rosacea is characterized by irritation associated with erythema, telangiectasias and papules/pustules. Whole formula nature-based sensitive skin products are formulated to maintain skin barrier and appropriate hydration that can lead to soothing benefits. Objective: To evaluate the efficacy and tolerability of a regimen consisting of a cleanser containing natural oils, beeswax, and witch hazel and day and night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol, sodium lauryl sulphate-containing cleanser, and glycerin, polyisobutene-containing lotion (CR) in subjects with rosacea. Methods: 80 female subjects with rosacea who received 6 weeks of 0.75% metronidazole gel, were randomized to receive NR or CR, twice daily, for 4 weeks in conjunction with the gel. Blinded investigator global assessment of rosacea, investigator-rated, and subject-rated overall skin appearance was assessed using a 5-point scale (0=none, 4=severe) at baseline, 2 weeks, and 4 weeks. Noninvasive skin assessments for skin hydration and skin barrier function were made by corneometry and TEWL, respectively. Results: NR resulted in improvement in investigator global assessment of rosacea measures at 4 weeks from baseline (erythema, 28%; telangiectasia, 26%; papules/pustules, 34%: P<0.001) and CR resulted in a 8 to 12% improvement. Differences between treatments were statistically significant. Overall skin appearance measured by the investigator was clinically and statistically improved from baseline by 32% and 12% with NR and CR, respectively. Overall skin appearance measured by subjects was improved by both NR and CR from baseline with no differences between treatments. Both regimens improved barrier function from baseline to week 4 (13%, NR; 14%, CR). NR decreased hydration by 21% from baseline at week 4 while CR increased hydration by 14% (P<0.001 from NR). No clinically significant tolerability issues were reported in either regimen at week 4. Conclusion: NR was effective, well tolerated, and superior to CR in the management of rosacea, concomitantly treated with metronidazole. National Clinical Trial Identifier: NCT03392558 J Drugs Dermatol. 2019;18(2):141-146.


Assuntos
Produtos Biológicos/administração & dosagem , Fármacos Dermatológicos/administração & dosagem , Metronidazol/administração & dosagem , Rosácea/terapia , Índice de Gravidade de Doença , Higiene da Pele/métodos , Adulto , Idoso , Terapia Combinada/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medicamentos sob Prescrição/administração & dosagem , Rosácea/diagnóstico , Creme para a Pele/administração & dosagem
14.
J Cosmet Dermatol ; 18(4): 960-965, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30809947

RESUMO

BACKGROUND: Rosacea is a highly prevalent, chronic inflammatory disease. The treatment of rosacea remains a challenge to dermatologists. Therapies include skin care, medications, lasers, and various combinations of these modalities. The appropriate treatment depends on clinical types and patient's various clinical symptoms. PURPOSE: The purpose of this study was to review and compare current therapies for rosacea of all severities from four different guidelines. METHODOLOGY: We searched PubMed using the keywords "rosacea," "treatment" AND ["erythema rosacea" OR "papulopustular rosacea" OR "ocular rosacea" OR "phymatous rosacea"]. We selected randomized controlled trials, observational studies, controlled clinical trials, and clinical trials. We indentified further studies (including the guidelines) by hand-searching relevant publications and included those that met the inclusion criteria. RESULTS: The total number of records identified was 421. We limited our search to the specific abovementioned study types. Twenty-five of these studies met with our inclusion criteria. An additional five manuscripts were selected using the abovementioned method, and four guidelines were included in this review. CONCLUSION: Diagnosing and choosing the appropriate treatment options of rosacea according to guidelines is the basis of scientific criteria. More large-scale randomized controlled clinical trials on new treatment methods, new drugs, or new dosage forms provide a new guideline for future rosacea treatment. Although there are some differences in the treatment of rosacea, it is generally based on anti-demodex, anti-inflammatory, and anti-angiogenesis.


Assuntos
Consenso , Guias de Prática Clínica como Assunto , Rosácea/terapia , Dermatologistas/normas , Dermatologia/normas , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Rosácea/diagnóstico , Índice de Gravidade de Doença , Resultado do Tratamento
16.
Artigo em Inglês | MEDLINE | ID: mdl-30621570

RESUMO

BACKGROUND: Rosacea is a frequently seen chronic disease. Certain allergens, some foods and beverages are known to trigger symptoms of rosacea. OBJECTIVE: We aimed to assess if nickel sensitivity is more common in rosacea patients than the normal population. METHOD: Fourty patients with rosacea and 40 healthy age and sex-matched volunteers were included in the study. From European standard patch test series, test units with nickel were applied on the skin of the upper back. According to the scheme of the International Contact Dermatitis Research Group (ICDRG), test results were evaluated at 48th, 72th and 96th hours. Seven days later, reevaluation was done for late reactions. Statistical analyses were done by using Statistics package for Social Sciences (SPSS) 17 package program and p<0.05 was accepted as statistically significant. RESULTS: Female/male ratio was 34/6 in patient group and 32/8 in control group. Mean age of the patient group and the control group were 39.97±12.65 (18-65 years), 40.82±11.79 (19-68 years), respectively. Age and sex distributions were found to be statistically similar. Nickel allergy in the patient and control group was found to be 52.5%, 22.5% respectively and the difference between groups was statistically significant (p=0. 006). CONCLUSION: Our results showed that there may be an association between nickel sensitivity and rosacea. Nickel sensitivity may be one of the underlying pathology or a triggering factor of the rosacea. Nickel restricted diet and avoiding the use of nickel-containing jewellery and piercings may extend the remission periods.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/epidemiologia , Níquel/efeitos adversos , Rosácea/diagnóstico , Rosácea/epidemiologia , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Dermatite Alérgica de Contato/imunologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro/métodos , Estudos Prospectivos , Rosácea/imunologia , Adulto Jovem
17.
J Dermatol ; 46(3): 219-225, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30656725

RESUMO

Although patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted to research the relationship between rosacea and dietary factors. The purpose of this study was to evaluate the potential relationship between rosacea and diet among the large Chinese population with rosacea, which would provide dietary guidelines for patients with rosacea. A multicenter case-control study was conducted. The feeding frequency 2 years before the occurrence of rosacea was collected by standardized questionnaires. Multiple logistic regression analysis was used to calculate risks related to the diet. One thousand three hundred and forty-seven patients with rosacea and 1290 controls were enrolled in our study. We found that high-frequency intake of fatty food and tea presented a positive correlation with rosacea, while high-frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high-frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high-frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high-frequency tea intake was only associated with ETR. In addition, high-frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea.


Assuntos
Comportamento Alimentar/fisiologia , Rosácea/etiologia , Adolescente , Adulto , Estudos de Casos e Controles , China , Laticínios , Gorduras na Dieta/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Rosácea/diagnóstico , Rosácea/prevenção & controle , Índice de Gravidade de Doença , Chá/efeitos adversos , Adulto Jovem
18.
J Am Acad Dermatol ; 80(6): 1722-1729.e7, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30240779

RESUMO

Rosacea has been reported less frequently among individuals with skin of color than in those with white skin, but rosacea is not a rare disease in this population. In fact, rosacea might be underreported and underdiagnosed in populations with skin of color because of the difficulty of discerning erythema and telangiectasia in dark skin. The susceptibility of persons with highly pigmented skin to dermatologic conditions like rosacea, whose triggers include sun exposure, is probably underestimated. Many people with skin of color who have rosacea might experience delayed diagnosis, leading to inappropriate or inadequate treatment; greater morbidity; and uncontrolled, progressive disease with disfiguring manifestations, including phymatous rosacea. In this article, we review the epidemiology of rosacea in skin of color and highlight variations in the clinical presentation of rosacea across the diverse spectrum of patient populations affected. We present strategies to aid in the timely diagnosis and effective treatment of rosacea in patients with skin of color, with an aim of promoting increased awareness of rosacea in these patients and reducing disparities in the management of their disease.


Assuntos
Rosácea/epidemiologia , Pigmentação da Pele , Acne Vulgar/diagnóstico , Grupos de Populações Continentais , Diagnóstico Tardio , Dermatite/diagnóstico , Diagnóstico Diferencial , Eritema/etiologia , Rubor/etiologia , Saúde Global , Disparidades em Assistência à Saúde , Humanos , Anamnese , Prevalência , Rosácea/complicações , Rosácea/diagnóstico , Rosácea/fisiopatologia , Avaliação de Sintomas , Telangiectasia/etiologia , Telangiectasia/terapia
19.
J Dermatol ; 46(1): 11-17, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30379346

RESUMO

Rosacea is thought to be associated with factors involved in metabolic syndrome (MetS). Muscle mass has a beneficial role in preventing MetS, but its link to rosacea remains unknown. We sought to investigate the association between rosacea severity and relative skeletal muscle mass. A cross-sectional study was conducted on subjects who attended a skin check-up program at the Kangbuk Samsung Hospital Health Screening Center between 2014 and 2016. Polarized light photographs of the face were taken and evaluated by two dermatologists. Skeletal muscle mass index (SMI, [%] = total skeletal muscle mass [kg] / bodyweight [kg] × 100) was estimated using a bioelectrical impedance analyzer. A logistic regression model was used to evaluate an association between SMI and rosacea. Of 110 rosacea subjects who were finally enrolled, 17 (15.5%) and 93 (84.5%) were classified as having papulopustular and erythematotelangiectatic rosacea, respectively. Categories of SMI comprised the following tertiles: 22.86-38.40%, 38.41-43.44% and 43.45-80.65%. In severity, compared with mild rosacea (75.5%), moderate rosacea (24.5%) incrementally increased as SMI decreased (Ptrend < 0.01). Severe rosacea was not observed. After adjustment for age and sex, odds ratios (95% confidence intervals) for moderate rosacea comparing SMI tertiles 1 and 2 to the highest tertile (reference) were 5.66 (1.22-26.20) and 4.43 (1.12-17.55), respectively (Ptrend = 0.03). This association was present in women with marginal significance (Ptrend = 0.06), but not in men. Relative muscle mass is negatively associated with an increased risk of more severe rosacea, suggesting that skeletal muscle can have a protective effect on rosacea exacerbation.


Assuntos
Músculo Esquelético , Rosácea/epidemiologia , Sarcopenia/epidemiologia , Adulto , Peso Corporal , Comorbidade , Estudos Transversais , Feminino , Voluntários Saudáveis , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Rosácea/diagnóstico , Índice de Gravidade de Doença , Fatores Sexuais
20.
Clin Exp Dermatol ; 44(4): 397-403, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30246390

RESUMO

BACKGROUND: Vitamin D has significant effects on the immune system and thereby on the pathogenesis of rosacea. However, there is a lack of information on the vitamin D status and vitamin D receptors (VDRs) of patients with rosacea. AIM: To evaluate the role of vitamin D in rosacea susceptibility. METHODS: A case-control study was conducted, enrolling patients with rosacea and healthy controls (HCs). Five VDR gene single nucleotide polymorphisms (SNPs) (Cdx2, FokI, ApaI, BsmI and TaqI) and serum 25-hydroxyvitamin D3 [25(OH)D3 ] levels were compared between patients and HCs. RESULTS: The study enrolled 60 patients (M/F: 14/46) and 60 age- and sex-matched HCs (M/F: 14/46). Age (mean ± SD) was 48 ± 11 years for both groups. The serum 25(OH)D3 levels (median ± interquartile range) were higher in patients with rosacea (12.9 ± 6.8 ng/mL) than in HCs (10.5 ± 3.7 ng/mL) (P < 0.001). Subjects with high serum 25(OH)D3 levels had a 1.36-fold increased risk of rosacea (95% CI 1.17-1.58). Heterozygous and mutant ApaI polymorphisms increased rosacea risk by 5.26-fold (95% CI 1.51-18.35) and 3.69-fold (95% CI 1.19-11.48), respectively, whereas mutant TaqI polymorphisms decreased the risk by 4.69 times (95% CI 1.37-16.67). Heterozygosity for Cdx2 alleles increased rosacea risk, whereas wildtype ApaI and mutant TaqI alleles decreased it. CONCLUSIONS: The present study suggests that an increase in vitamin D levels may contribute to the development of rosacea. ApaI and TaqI polymorphisms, and heterozygous Cdx2, wildtype ApaI and mutant TaqI alleles were significantly associated with rosacea. These results indicate a possible role of vitamin D and VDR pathways in the pathogenesis of rosacea, although causality could not be assessed.


Assuntos
Receptores de Calcitriol/genética , Rosácea/metabolismo , Vitamina D/análogos & derivados , Vitamina D/sangue , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Heterozigoto , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Rosácea/diagnóstico , Rosácea/patologia , Dermatopatias/metabolismo , Dermatopatias/patologia , Vitamina D/metabolismo
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