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1.
Braz. j. pharm. sci ; 50(4): 851-858, Oct-Dec/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-741338

RESUMO

Rosmarinus officinalis, which belongs to the Lamiaceae family, is a species of medicinal flora with therapeutic properties. In order to exploit the benefits of these properties, a mouthwash formulation was developed, with careful selection of raw materials to meet pharmacotechnical requirements. Extracts of the plant were incorporated into a mouthwash, which was shown to have inhibitory action in vitro against the micro-organisms commonly found in periodontics. Controls for assessing the quality of the drugs were carried out, quantifying phenols and flavonoids as chemical markers. Mouthwash solutions were formulated containing 0.1, 5 and 10% ethanol extract of R. officinalis; and 0.05, 5 and 10% of the hexane fraction of R. officinalis. In order to evaluate synergism, ethanol extract and hexane fraction were also added to formulations containing 0.05% sodium fluoride and 0.12% chlorhexidine digluconate. These formulations were assessed for inhibitory effect against the specific microorganisms involved in the process of bacterial plaque formation, S. mutans (ATCC25175) and C. albicans(ATCC 10231), frequently found in cases of oral infections. The agar diffusion method was used to evaluate the inhibitory activity of extracts and formulations. All mouthwash solutions displayed inhibitory activity having higher sensitivity to S. mutans for the 5% ethanol extract+0.05% sodium fluoride, and greater sensitivity to C. albicans for the 10% hexane fraction. Results were characterized by the appearance of a growth inhibition halo, justifying the utilization and association of extracts of R. officinalis.


Rosmarinus officinalis, pertencente à família Lamiaceae, é um exemplar da flora medicinal que possui propriedades terapêuticas. No intuito de usufruir destes benefícios, desenvolveu-se uma formulação de enxaguatório bucal com seleção criteriosa de matérias-primas que atendessem os requisitos farmacotécnicos. Incorporaram-se extratos dessa planta e verificou-se a capacidade inibitória in vitro frente a micro-organismos frequentemente encontrados em periodontias. Controles foram efetuados para a avaliação da qualidade dos fármacos, quantificando-se como marcadores químicos, os fenóis e os flavonóides. Formulações de enxaguatórios contendo 0,1, 5 e 10% de extrato etanólico de R. officinalis; e 0,05, 5 e 10% da fração hexânica de R. officinalis foram preparadas. Para avaliar o sinergismo, o extrato e a fração hexânica também foram adicionados às formulações que continham fluoreto de sódio 0,05% e diguclonato de clorexidina 0,12%. Nessas formulações avaliou-se a capacidade inibitória frente a micro-organismos específicos do processo de formação de placa bacteriana, S. mutans (ATCC 25175) e C. albicans (ATCC 10231), frequentemente encontrada em quadros de infecções orais. Foi empregado o método de difusão em ágar para a avaliação da atividade inibitória dos extratos e das formulações. Todos os enxaguatórios demonstraram atividade inibitória, verificando-se maior sensibilidade a S. mutans, quando se utilizou extrato etanólico 5% + fluoreto de sódio 0,05% e sensibilidade maior a C. albicans, quando se utilizou fração hexânica a 10%. Os resultados foram caracterizados pelo aparecimento de halo de inibição de crescimento, justificando a utilização e associação dos extratos de R. officinalis.


Assuntos
Antissépticos Bucais/farmacologia , Rosmarinus/análise , Periodontia/classificação , Extratos Vegetais
2.
Braz. j. microbiol ; 43(4): 1419-1427, Oct.-Dec. 2012. tab
Artigo em Inglês | LILACS | ID: lil-665828

RESUMO

Antimicrobial active packaging delays or inhibits microorganism growth in packed products, and it can be used in a variety of food systems. The objective of the present research was to develop packaging incorporated with natural antimicrobial agents (active film). The effects of the active film on the spoilage, pathogenic microorganism counts, pH and color of the refrigerated chicken breast cuts were analyzed. Cellulose acetate-based active films incorporating two concentrations (20% and 50%, v/w) of rosemary (Rosmarinus officinalis L.) essential oil were manufactured and placed in contact with the chicken breast cuts for six days. An analysis of variance and mean comparison tests (Tukey's test, p<0.05) were performed on the results. The films that contained 20% essential oil and were intercalated with chicken breast samples did not demonstrate significant effects on the control of psychrotrophic or total coliform microorganisms during the storage period; however, the films incorporated with 50% essential oil demonstrated efficacy toward the control of coliforms during the storage of the samples (6 days, 2 ± 2ºC). The pH was related to the psychrotrophic microorganism count and was not influenced by the treatment. The color was not influenced by the time of storage or the treatment. The results demonstrate that active films incorporating 50% rosemary essential oil are effective at controlling certain microorganisms in chicken breast cuts.


Assuntos
Animais , Alimentos Congelados/análise , Antibacterianos/análise , Análise de Alimentos , Embalagem de Alimentos , Técnicas In Vitro , Produtos Avícolas/análise , Rosmarinus/análise , Contaminação de Alimentos , Microbiologia de Alimentos , Amostras de Alimentos , Métodos , Aves Domésticas
3.
Ars pharm ; 50(3): 124-128, jul.-sept. 2009. tab
Artigo em Inglês | IBECS | ID: ibc-77750

RESUMO

The content of α-glucoxidase in two varieties of honey covered by the Granada Honey Protected Denomination of Origin Regulatory Board is studied. The evolution of invertase activity was followed for 10 months, in 12 monofloral chestnut honey samples collected in the Alpujarra area of Granada and 9 monofloral rosemary honey samples collected in la Resinera, Valle de Lecrin and in the Sierra de Baza for 10 months. The invertase was measured in the months of June 2005, September 2005, January 2006 and finally in the month of April 2006. We obtained an invertase activity in fresh chestnut honey of 194.6±3.6 U/kg, with a range between 188.7 U/kg and 199.5 U/kg. After 10 months at ambient temperature, the chestnut honey lost between 28.3% and 39.8% of the initial values of α-glucosidase, with an average of 33.4%±3.3%. In the rosemary honey we obtained average invertase values of 69.4±14.9 U/kg, with a range between 56.9 U/kg and 91.9 U/kg. After 10 months at ambient temperature, the rosemary honey lost between 19.3% and 32.3% of the initial α-glucosidase values, with an average of 28.1%±4.4%(AU)


Assuntos
Humanos , Castanea vesca/farmacologia , Rosmarinus/farmacologia , Mel , Castanea vesca/análise , Rosmarinus/análise
4.
Cahiers bioth ; (122): 31-8, jun.-jul. 1993. Tab, ilus
Artigo em Francês | HomeoIndex - Homeopatia | ID: hom-2482

RESUMO

Le romarin, Rosmarinus officinalis, est traditionnellement utilise dans les affections de la sphere hepatobiliaire sous forme d'infusion aqueuse ou de solutions hydro-alcooliques de degres divers. Il fait partie de la famille des Lamiacees dont plusieurs representants semblent presenter des proprietes antioxydantes particulierement interessantes. Des travaux recents ont montre, sur des modeles in vitro, que le romarin s'opposait aux consequences toxiques de la production de radicaux libres et notamment aux desordres membranaires provoques par la peroxydation lipidique


Assuntos
Rosmarinus/análise
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