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1.
Br Dent J ; 230(7): 385-386, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33837310
2.
Pan Afr Med J ; 38: 133, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33912303

RESUMO

Syphilis is known as the great imitator with various clinical presentations which often lead to confusion and misdiagnosis. A 28-year-old male presented with non-pruritic and painless erythematous patches around the anus and scrotum. Initial differential diagnosis with tinea cruris. Fungal examination was negative. Serological tests for syphilis were positive and anti-HIV screening was reactive. A diagnosis of secondary syphilis was established and the patient was given intramuscular injection of 2.4 million unit of benzathine penicillin. The skin lesions improved significantly 1 week after treatment, confirming a diagnosis of secondary syphilis with HIV. Annular skin lesions in secondary syphilis are uncommon and often misleading. This case emphasizes the importance of considering secondary syphilis in the differential diagnosis of annular lesions.


Assuntos
Antibacterianos/administração & dosagem , Penicilina G Benzatina/administração & dosagem , Sífilis/diagnóstico , /diagnóstico , Adulto , Diagnóstico Diferencial , Exantema/diagnóstico , Exantema/microbiologia , Infecções por HIV/complicações , Humanos , Injeções Intramusculares , Masculino , Dermatopatias/diagnóstico , Dermatopatias/microbiologia , Sífilis/tratamento farmacológico
3.
BMC Infect Dis ; 21(1): 378, 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33888090

RESUMO

BACKGROUND: Sexually transmitted infections (STIs) such as Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Syphilis have continued a significant public health problem, especially in areas with substandard infection prevention and control programs. It is known that STIs are largely associated with the increased occurrence of cervical cancer. To date, little is known about the burden of STIs among cervical cancer suspected women in Ethiopia. OBJECTIVES: To assess the seroprevalence of STIs and associated risk factors among cervical cancer suspected women with special emphasis on HIV, HBV, HCV, and Syphilis. METHODS: A hospital-based cross-sectional study was conducted among cervical cancer suspected women at the University of Gondar Comprehensive Specialized Hospital from February to April 2017. A pre-tested and structured questionnaire was used to collect data on patients' characteristics. The patient's serum or plasma samples were tested for HIV, HBV, HCV, and syphilis using enzyme-linked immunosorbent assay. In all aspects, the standard operational procedure was strictly followed. Data were analyzed using SPSS version 20 software and presented using tables. Statistical associations were measured using bivariate and multivariable logistic regression. A p-value of below 0.05 was considered statistically significant. RESULT: A total of 403 cervical cancer suspected women with the mean age of 42.54 (SD + 11. 24) years were enrolled in the study. The overall prevalence of STIs was 16.6% (67/403) and the prevalence of HIV, HBV, HCV, and syphilis was 36/403 (8.9%), 10/403 (2.5%), 4/403 (1%), and 29/403 (7.2%) respectively. History of multiple sexual partners (Adjusted OR = 3.02, 95%CI 1.57-5.79, P = 0.001), alcohol addiction (Adjusted OR = 2.2, 95%CI 1.07-4.5, P = 0.031), history of STI (Adjusted OR = 3.38; 95% CI: 1.76-6.47, P = 0.00) and not use of condom (Adjusted OR = 4.99; 95% CI: 1.5-16.16, P = 0.007) were significantly associated with STIs. CONCLUSION: The prevalence of STIs was generally higher among cervical cancer suspected patients. Health education is encouraged to promote awareness about the prevention of STIs.


Assuntos
Doenças Sexualmente Transmissíveis/diagnóstico , Neoplasias do Colo do Útero/patologia , Adulto , Alcoolismo/complicações , Estudos Transversais , Etiópia/epidemiologia , Feminino , Infecções por HIV/diagnóstico , Infecções por HIV/epidemiologia , Hepatite B/diagnóstico , Hepatite C/diagnóstico , Hepatite C/epidemiologia , Hospitais Especializados , Humanos , Pessoa de Meia-Idade , Razão de Chances , Prevalência , Fatores de Risco , Parceiros Sexuais , Doenças Sexualmente Transmissíveis/complicações , Doenças Sexualmente Transmissíveis/epidemiologia , Inquéritos e Questionários , Sífilis/diagnóstico , Sífilis/epidemiologia
5.
Medicine (Baltimore) ; 100(9): e24452, 2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33655916

RESUMO

RATIONALE: Ocular syphilis varies widely in presentation and should be considered in all patients with posterior uveitis. Necrotizing retinitis is a rare manifestation of ocular syphilis and mimics ARN. PATIENT CONCERNS: We report a male patient who presented with bilateral dense vitritis obscuring fundus details similar to ARN, as a rare reported manifestation of syphilis, who was initially given intravitreal ganciclovir. DIAGNOSIS: After the results for herpes viral PCR disclosed negative, the diagnosis of syphilitic necrotizing retinitis was made based on positive RPR. INTERVENTION AND OUTCOMES: With the clinical diagnosis of ocular syphilis, treatment with intravenous penicillin was promptly initiated. His visual acuity improved to 20/100 in the right eye and still light perception in the left. Pars plana vitrectomy with silicon oil tamponade was performed in his left eye. LESSONS: Ocular syphilis varies widely in presentation and should be considered in all patients with posterior uveitis. However, whenever ARN is clinically suspected, empiric treatment against herpetic viruses should be promptly administered while awaiting further infectious disease study results. Recognition of syphilitic retinitis and prompt initiation of intravenous penicillin is of critical important for clinicians.


Assuntos
Infecções Oculares Bacterianas/complicações , Síndrome de Necrose Retiniana Aguda/microbiologia , Retinite/microbiologia , Sífilis/complicações , Treponema pallidum , Infecções Oculares Bacterianas/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Sífilis/microbiologia
6.
Medicine (Baltimore) ; 100(10): e25047, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33725889

RESUMO

RATIONALE: Nevus sebaceous (NS) is a lesion caused by congenital hyperplastic disorder of the sebaceous glands. It commonly noted in the scalp and face and rarely in the trunk, neck, or oral mucosa. We present a rare case of a lesion arising in the genital region. PATIENT CONCERNS: A 47-year-old woman complained of a gradual increase in the size of her bilateral labia minora over 2 years, which affected her sexual life and caused walking difficulty. She was admitted to the Department of Obstetrics and Gynecology. On physical examination, no ulcer, discharge, and vulval or vaginal bleeding were found. The bilateral inguinal lymph nodes were not palpable, bilateral labia minora were asymmetric, and the right side was evidently bigger than the left. The labia minora had serrated edges and numerous papillae with a maximum diameter of 0.5 cm. The vagina, cervix, and uterus with its attachments were normal. Blood samples tested negative for human immunodeficiency virus, human papilloma virus, hepatitis B virus, and hepatitis C virus. DIAGNOSIS: A diagnosis of NS of the bilateral labia minora was made following histopathological examination of the resected specimen. INTERVENTION: The bilateral labia minora lesions were resected general anesthesia on August 29, 2016. The operation was successful, and intraoperative blood loss was about 10 ml. OUTCOMES: After 40 months of postoperative follow-up, no recurrence or appearance of other tumors were noted. LESSONS: We recommend surgical removal of lesions in the genital area during adolescence or before adulthood. Adolescence may be the best period for surgical intervention owing to a greater risk of malignant change in adulthood. On the other hand, surgical risk should be avoided in children considering the low incidence of malignant transformation.


Assuntos
Nevo/diagnóstico , Neoplasias das Glândulas Sebáceas/diagnóstico , Neoplasias Vulvares/diagnóstico , Diagnóstico Diferencial , Feminino , Procedimentos Cirúrgicos em Ginecologia , Humanos , Pessoa de Meia-Idade , Nevo/patologia , Nevo/cirurgia , Neoplasias das Glândulas Sebáceas/patologia , Neoplasias das Glândulas Sebáceas/cirurgia , Glândulas Sebáceas/patologia , Glândulas Sebáceas/cirurgia , Sífilis/diagnóstico , Vulva/patologia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgia
9.
Arq Neuropsiquiatr ; 79(2): 103-106, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33759975

RESUMO

BACKGROUND: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. OBJECTIVE: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). METHODS: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients were classified according to the ASCOD phenotyping as SVD - when SVD was the potential causal mechanism (S1) - or non-SVD - when SVD was uncertain (S2), unlike (S3), or not detected (S0). RESULTS: Syphilis was positive in 32 (12%) patients. When comparing patients with positive and negative serology, the only significant difference was SVD as the causal mechanism (S1) in patients with positive results: 9 (28%) vs. 22 (9%), p<0.01. CONCLUSION: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis.


Assuntos
Isquemia Encefálica , Acidente Vascular Cerebral , Sífilis , Isquemia Encefálica/complicações , Humanos , Sífilis/complicações , Sífilis/epidemiologia , Sorodiagnóstico da Sífilis
10.
Artigo em Inglês | MEDLINE | ID: mdl-33533807

RESUMO

Syphilis, an infectious disease considered a global public health concern, can cause stillbirths and neonatal deaths. This highlights the importance of continuous surveillance studies among women of reproductive age. A cross-sectional study was carried out to analyze the prevalence and risk factors associated with Treponema pallidum infection in women assisted by primary health care units in Dourados, a city located in Mato Grosso do Sul State, Brazil, which borders Paraguay. A questionnaire was applied to a population-based sample, blood samples were collected for syphilis testing and multivariable analyses were performed to screen associations with T. pallidum infection. The prevalence of T. pallidum infection was 6.04%. Bivariate analysis showed that women referring multiple sexual partners (c2: 6.97 [p=0.014]), income less 2 minimal wages (c2: 15.93 [p=0.003]), who did not have high school (c2: 12.64 [p=0.005]), and reporting history of STIs (c2: 7.30 [p=0.018]) are more likely to have syphilis. In the multivariate analysis, a highest prevalence ratio was observed in women with income less than 2 minimal wages (PR: 0.96 [95% CI: 0.85 - 0.97]), and who did not have high school (PR: 0.94 [95% CI: 0.90 - 0.98]). In addition, 80% of the women reported irregular use of condoms and 63.89% declared having sexual intercourses with multiple partners, which creates more opportunities for the transmission of the infection. These results highlight the need for healthcare systems to implement initiatives to monitor syphilis screening and the commitment of patients and their sexual partners to the treatment in order to achieve a decrease of new cases.


Assuntos
Sífilis/epidemiologia , Treponema pallidum/isolamento & purificação , Adulto , Idoso , Brasil/epidemiologia , Cidades , Preservativos , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Prevalência , Saúde Pública , Estudos Soroepidemiológicos , Sífilis/diagnóstico , Sexo sem Proteção
11.
Rev. bras. promoç. saúde (Impr.) ; 34: 1-10, 17/02/2021.
Artigo em Inglês, Português | LILACS | ID: biblio-1152110

RESUMO

Objetivo: Analisar o conhecimento de mulheres que realizaram consultas de pré-natal em relação à sífilis e as orientações recebidas acerca da prevenção de sífilis gestacional. Métodos: Pesquisa qualitativa e descritiva, desenvolvida com oito gestantes, em uma unidade de Atenção Primária à Saúde (APS), de um município de Fronteira Oeste, Rio Grande do Sul, Brasil, por meio da técnica de entrevista semiestruturada, no período de setembro a outubro de 2019. Os achados foram interpretados por meio da análise temática, emergindo duas categorias temáticas: Conhecimento sobre a sífilis e Orientações sobre a prevenção da sífilis na gestação. Resultados: As gestantes investigadas demonstraram conhecimento restrito sobre sífilis e sífilis gestacional. Relataram que as orientações no pré-natal são superficiais. Disseram que a transmissão da sífilis ocorre por via sexual e demonstraram surpresa quanto às complicações da doença para o bebê, evidenciando o desconhecimento sobre a sífilis congênita. Citaram o preservativo como método de prevenção, porém relataram não utilizar quando o parceiro é fixo. Demonstraram conhecimento restrito sobre a interpretação dos testes rápidos, não mencionando a realização do exame não treponêmico como método diagnóstico e confirmatório da doença. Conclusão: A lacuna identificada pelo conhecimento limitado das gestantes investigadas sobre a sífilis e a prevenção da sífilis gestacional pode ser suprida por meio da realização de atividades de educação em saúde, tendo o enfermeiro como agente promotor.


Objective: To analyze the knowledge of women who attended prenatal consultations concerning syphilis and the guidelines received about the prevention of gestational syphilis. Methods: It is qualitative and descriptive research, developed with eight pregnant women, in a unit of Primary Health Care (PHC), in a municipality of Fronteira Oeste, Rio Grande do Sul, Brazil, using the semi-structured interview technique from September to October 2019. The findings were interpreted using thematic analysis, with two thematic categories emerging: Knowledge about syphilis and Guidelines on the prevention of syphilis in pregnancy. Results: The investigated pregnant women demonstrated restricted knowledge about syphilis and gestational syphilis. They reported that the guidelines for prenatal care are superficial. They said that the transmission of syphilis happens through sex and showed surprise about the complications of the disease for the baby, showing the lack of knowledge about congenital syphilis. They mentioned the condom as a prevention method but reported not using it when the partner is fixed. They demonstrated limited knowledge about the interpretation of rapid tests, not to mention the non-treponemal exam as a diagnostic and confirmatory method of the disease. Conclusion: The gap identified by the limited knowledge of pregnant women investigated about syphilis, and the prevention of gestational syphilis can be filled by carrying out health education activities, with the nurse as a promoter.


Objetivo: Analizar el conocimiento de mujeres que tuvieron el prenatal sobre la sífilis y las orientaciones recibidas sobre la prevención de la sífilis gestacional. Métodos: Investigación cualitativa y descriptiva desarrollada con ocho embarazadas de una unidad de Atención Primaria de Salud (APS) de un municipio de la Frontera Oeste, Río Grande de Sur, Brasil a través de la técnica de entrevista semiestructurada en el periodo entre septiembre y octubre de 2019. Se ha interpretado los hallazgos a través del análisis temático del cual se ha identificado dos categorías temáticas a continuación: Conocimiento de la sífilis y Orientaciones sobre la prevención de la sífilis durante el embarazo. Resultados: Las embarazadas investigadas han demostrado poco conocimiento de la sífilis y de la sífilis gestacional. Ellas han relatado que las orientaciones del prenatal son superficiales, que la transmisión de la sífilis se da por la vía sexual y han demostrado sorpresa sobre las complicaciones de la enfermedad para el bebé lo que evidencia la falta de conocimiento de la sífilis congénita. Ellas han citado el condón como el método de prevención, sin embargo, relataron no usarlo cuando tiene más tiempo con su compañero. Las participantes han demostrado poco conocimiento de la interpretación de las pruebas rápidas y no han mencionado la prueba no treponémica como el método diagnóstico y confirmatorio de la enfermedad. Conclusión: Se pude arreglar la laguna del conocimiento limitado de las embarazadas investigadas sobre la sífilis y la prevención de la sífilis gestacional a través de actividades de educación en salud con el enfermero como el agente promotor.


Assuntos
Gravidez , Sorodiagnóstico da Sífilis , Sífilis , Saúde da Mulher , Enfermagem , Gestantes
13.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(2): 273-277, 2021 Feb 10.
Artigo em Chinês | MEDLINE | ID: mdl-33626615

RESUMO

Objective: To evaluate the effectiveness of HIV/syphilis joint self-testing in promoting syphilis testing among men who have sex with men (MSM). Methods: In July 2019, the research participants were recruited through the Danlan website (https://www.danlan.org). Participants who met the selection criteria, and were randomly assigned into one of the three study groups (1∶1∶1) including HIV/syphilis joint self-testing group and lottery incentive self-testing group and control group. Self-test reagents were mailed to HIV/syphilis joint self-testing group and lottery incentive self-testing group, and the subjects in control group were encouraged to go to offline locations for testing. One month later, follow-up was conducted to evaluate the differences in the testing rates of syphilis among the three groups. Results: A total of 145 subjects were included in this study, including 48 in control group, 49 in HIV/syphilis joint self-testing group and 48 in lottery incentive self-testing group. During the follow-up period, the self-testing rate of syphilis was 74.4% (32/43) in HIV/syphilis joint self-testing group, 70.0% (28/40) in lottery incentive self-testing group and 36.4% (16/44) in control group. Multivariate logistic analysis revealed that the proportions of syphilis testing in HIV/syphilis joint self-testing group and lottery incentive self-testing group were 5.38 (95%CI: 2.06-14.04) times and 4.54 (95% CI: 1.75-11.74) times higher than that in control group during the follow-up period. Conclusions: HIV/syphilis joint self-testing and lottery-incentives-prompted self-testing significantly increased the testing rate of syphilis in MSM, respectively. HIV/syphilis joint self-testing is feasible for promotion.


Assuntos
Infecções por HIV , Homossexualidade Masculina , Sífilis , Infecções por HIV/diagnóstico , Humanos , Masculino , Sífilis/diagnóstico
14.
Sex Transm Dis ; 48(5): 381-384, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33534404

RESUMO

ABSTRACT: During the initial height of COVID-19 in New York State excluding New York City in March 2020, reports of sexually transmitted infections declined. Prediction models developed to estimate the incidence of early syphilis and gonorrhea during the COVID-19 pandemic were used to study impact on STI diagnoses/reporting and inform sexual health program planning.


Assuntos
Modelos Teóricos , Doenças Sexualmente Transmissíveis/epidemiologia , Gonorreia/epidemiologia , Humanos , Incidência , New York/epidemiologia , Pandemias , Sífilis/epidemiologia
15.
Acta Med Hist Adriat ; 18(2): 375-397, 2021 12.
Artigo em Italiano | MEDLINE | ID: mdl-33535768

RESUMO

Syphilis is the prime example of a "new disease" which triggered a transnational (European) discussion among physicians. It appeared between the end of the Middle Ages and the beginning of the Modern Times (at the beginning of the sixteenth century), a time in which medicine was changing from a dogmatic to an experimental discipline. The main changes were in the field of anatomy: in 1543, the same year of the astronomy-disrupting work by Nicolas Copernicus, the new less dogmatic and more empirical approach to anatomy by Andreas Vesalius was published. Nevertheless, in the Renaissance, medicine remains a tradition-bound discipline, proud of its millennial history and its superiority over the empirical, non-academic healers. When syphilis appeared in Europe, several explanations were elaborated. In the mid-16th century, an Italian doctor Luigi Luigini (born in 1526) published in Venice a collection of all the works on syphilis that appeared until 1566. He wanted to entrust to colleagues, contemporary and future, a compendium of all that was known about the "new" disease (the Latin term Novus means both "new" and "strange"). According to the most authors of the collection, the disease is in fact "new" and "strange". Some authors of the collection find it impossible that authorities like Hippocrates and Galen overlooked it. Luigini's work shows the authors' effort to absorb syphilis in the corpus of academic medicine and affirm the authority of academic physicians against the empirical healers.


Assuntos
Médicos/história , Sífilis/história , Europa (Continente) , História do Século XVI , Humanos , Itália
16.
An Bras Dermatol ; 96(2): 228-230, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33593700

RESUMO

As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.


Assuntos
Doença de Crohn , Sífilis , Tuberculose Cutânea , Doença de Crohn/tratamento farmacológico , Humanos , Infliximab/efeitos adversos , Pele , Tuberculose Cutânea/induzido quimicamente , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/tratamento farmacológico
17.
Nihon Shokakibyo Gakkai Zasshi ; 118(2): 161-167, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-33563856

RESUMO

A 44-year-old man was admitted because of general malaise, jaundice, and epigastric pain. The patient had no significant medical history. However, the patient visited a brothel 3 months ago and noticed initial induration on his penis 2 months ago. Physical examination revealed swelling surface lymph nodes in the inguinals. Laboratory examination showed moderate hepatic disorder and jaundice. Hepatitis virus markers and various types of autoantibodies were negative, but serological test for syphilis was positive. The symptoms and abnormal data improved immediately after the patient was treated with amoxicillin (3000mg/day) and probenecid (750mg/day). Thus, a diagnosis of early syphilitic hepatitis was established. In addition, syphilis is not just a genital disease. This disease should be thought of in a patient with liver dysfunction, especially among people of high sexual activity.


Assuntos
Hepatite , Icterícia , Sífilis , Adulto , Amoxicilina , Hepatite/complicações , Hepatite/tratamento farmacológico , Humanos , Masculino , Probenecid , Sífilis/complicações , Sífilis/diagnóstico , Sífilis/tratamento farmacológico
18.
BMC Pregnancy Childbirth ; 21(1): 98, 2021 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-33516183

RESUMO

BACKGROUND: This study estimated the prevalence of curable sexually transmitted and reproductive tract infections (STIs/RTIs) among pregnant women attending antenatal care (ANC) in rural Zambia, evaluated the effectiveness of syndromic management of STIs/RTIs versus reference-standard laboratory diagnoses, and identified determinants of curable STIs/RTIs during pregnancy. METHODS: A total of 1086 pregnant women were enrolled at ANC booking, socio-demographic information and biological samples were collected, and the provision of syndromic management based care was documented. The Piot-Fransen model was used to evaluate the effectiveness of syndromic management versus etiological testing, and univariate and multivariate logistic regression analyses were used to identify determinants of STIs/RTIs. RESULTS: Participants had a mean age of 25.6 years and a mean gestational age of 22.0 weeks. Of 1084 women, 700 had at least one STI/RTI (64.6%; 95% confidence interval [CI], 61.7, 67.4). Only 10.2% of infected women received any treatment for a curable STI/RTI (excluding syphilis). Treatment was given to 0 of 56 women with chlamydia (prevalence 5.2%; 95% CI, 4.0, 6.6), 14.7% of participants with gonorrhoea (prevalence 3.1%; 95% CI, 2.2, 4.4), 7.8% of trichomoniasis positives (prevalence 24.8%; 95% CI, 22.3, 27.5) and 7.5% of women with bacterial vaginosis (prevalence 48.7%; 95% CI, 45.2, 51.2). An estimated 7.1% (95% CI, 5.6, 8.7) of participants had syphilis and received treatment. Women < 20 years old were more likely (adjusted odds ratio [aOR] = 5.01; 95% CI: 1.23, 19.44) to have gonorrhoea compared to women ≥30. The odds of trichomoniasis infection were highest among primigravidae (aOR = 2.40; 95% CI: 1.69, 3.40), decreasing with each subsequent pregnancy. Women 20 to 29 years old were more likely to be diagnosed with bacterial vaginosis compared to women ≥30 (aOR = 1.58; 95% CI: 1.19, 2.10). Women aged 20 to 29 and ≥ 30 years had higher odds of infection with syphilis, aOR = 3.96; 95% CI: 1.40, 11.20 and aOR = 3.29; 95% CI: 1.11, 9.74 respectively, compared to women under 20. CONCLUSIONS: Curable STIs/RTIs were common and the majority of cases were undetected and untreated. Alternative approaches are urgently needed in the ANC setting in rural Zambia.


Assuntos
Coinfecção/epidemiologia , Complicações Infecciosas na Gravidez/epidemiologia , Infecções do Sistema Genital/epidemiologia , Doenças Sexualmente Transmissíveis/epidemiologia , Adulto , Coinfecção/diagnóstico , Coinfecção/parasitologia , Estudos Transversais , Feminino , Gonorreia/diagnóstico , Gonorreia/epidemiologia , Humanos , Modelos Logísticos , Análise Multivariada , Gravidez , Cuidado Pré-Natal , Prevalência , Infecções do Sistema Genital/diagnóstico , Infecções do Sistema Genital/parasitologia , População Rural , Doenças Sexualmente Transmissíveis/diagnóstico , Doenças Sexualmente Transmissíveis/parasitologia , Fatores Socioeconômicos , Sífilis/epidemiologia , Tricomoníase/epidemiologia , Vaginose Bacteriana/epidemiologia , Vaginose Bacteriana/parasitologia , Adulto Jovem , Zâmbia/epidemiologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-33503917

RESUMO

Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) diagnosis, confirmation of infection using laboratory tools is essential to choose the most appropriate course of treatment and to screen at-risk groups. Numerous laboratory tests and platforms have been developed for gonorrhea, chlamydia, syphilis, trichomoniasis, genital mycoplasmas, herpesviruses, and human papillomavirus. Point-of-care testing is now a possibility, and microfluidic and high-throughput omics technologies promise to revolutionize the diagnosis of STIs. The scope of this paper is to provide an updated overview of the current laboratory diagnostic tools for these infections, highlighting their advantages, limitations, and point-of-care adaptability. The diagnostic applicability of the latest molecular and biochemical approaches is also discussed.


Assuntos
Infecções por Chlamydia , Gonorreia , Infecções por HIV , Doenças Sexualmente Transmissíveis , Sífilis , Técnicas de Laboratório Clínico , Humanos , Prevalência , Doenças Sexualmente Transmissíveis/diagnóstico , Doenças Sexualmente Transmissíveis/epidemiologia
20.
Matern Child Health J ; 25(2): 198-206, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33394275

RESUMO

INTRODUCTION: Public health responses often lack the infrastructure to capture the impact of public health emergencies on pregnant women and infants, with limited mechanisms for linking pregnant women with their infants nationally to monitor long-term effects. In 2019, the Centers for Disease Control and Prevention (CDC), in close collaboration with state, local, and territorial health departments, began a 5-year initiative to establish population-based mother-baby linked longitudinal surveillance, the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET). OBJECTIVES: The objective of this report is to describe an expanded surveillance approach that leverages and modernizes existing surveillance systems to address the impact of emerging health threats during pregnancy on pregnant women and their infants. METHODS: Mother-baby pairs are identified through prospective identification during pregnancy and/or identification of an infant with retrospective linking to maternal information. All data are obtained from existing data sources (e.g., electronic medical records, vital statistics, laboratory reports, and health department investigations and case reporting). RESULTS: Variables were selected for inclusion to address key surveillance questions proposed by CDC and health department subject matter experts. General variables include maternal demographics and health history, pregnancy and infant outcomes, maternal and infant laboratory results, and child health outcomes up to the second birthday. Exposure-specific modular variables are included for hepatitis C, syphilis, and Coronavirus Disease 2019 (COVID-19). The system is structured into four relational datasets (maternal, pregnancy outcomes and birth, infant/child follow-up, and laboratory testing). DISCUSSION: SET-NET provides a population-based mother-baby linked longitudinal surveillance approach and has already demonstrated rapid adaptation to COVID-19. This innovative approach leverages existing data sources and rapidly collects data and informs clinical guidance and practice. These data can help to reduce exposure risk and adverse outcomes among pregnant women and their infants, direct public health action, and strengthen public health systems.


Assuntos
Defesa Civil/métodos , Relações Mãe-Filho , Vigilância da População/métodos , Adulto , /diagnóstico , Defesa Civil/instrumentação , Feminino , Hepatite C/complicações , Hepatite C/diagnóstico , Humanos , Recém-Nascido , Programas de Rastreamento/métodos , Gravidez , Sífilis/complicações , Sífilis/diagnóstico
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