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1.
J Assoc Physicians India ; 67(3): 60-62, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31304708

RESUMO

Background: It is accepted that metabolic syndrome increases the relative risk of cardiovascular disease and visceral adiposity lies at root of the cardio-metabolic risk. Upper body fat distribution has long been recognized as associated with metabolic syndrome and increased cardiovascular risk; hence the present study was conducted with the objective to evaluate the association of neck circumference with metabolic syndrome and cardiovascular risk factors. Material and Methods: The present study was a hospital based observational, Descriptive and comparative analysis, conducted at Department of General Medicine at a tertiary care centre of west India after Ethical clearance from the institute's ethical committee and written informed consent. A total of 405 subjects aged 18 - 60 years were selected consecutively after inclusion and exclusion criteria. Subjects were evaluated for metabolic syndrome components and cardiovascular risk factors. Neck circumference of ≥ 37 cm in males and ≥ 34 cm in females was considered abnormal. Results: Metabolic syndrome was seen in 189 (46.7%) subjects. Raised triglyceride level was the most common (52.8%) component. Neck circumference was found to be statistically significant associated with metabolic syndrome (p<0.001) as well as cardiovascular risk factors like BMI, Waist circumference, Hypertension, Fasting blood sugar, TG and HDL were also found to be statistically significant associated with neck circumference. Conclusion: Neck Circumference can be used as a sensitive tool for metabolic syndrome and cardiovascular risk factors. Patients with abnormal Neck circumference should be screened for cardiovascular risk factors to detect abnormality for early and appropriate intervention.


Assuntos
Doenças Cardiovasculares/epidemiologia , Síndrome Metabólica/epidemiologia , Pescoço/anatomia & histologia , Adolescente , Adulto , Biometria , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Abdominal , Fatores de Risco , Circunferência da Cintura , Adulto Jovem
2.
J Assoc Physicians India ; 67(4): 52-54, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31309797

RESUMO

Background: Psoriasis is a chronic inflammatory and hyper-proliferative skin disorder which is chronically relapsing with high morbidity and impaired quality of life, characterized by erythematous scaly patches affecting skin, joints and nails. It is a disorder of immune system involving genetic, immunologic and environtmental factors. Metabolic syndrome (also known as metabolic syndrome X) is a grouping of interrelated medical traits that, when present, indicate an increased risk of developing noninsulin-dependent diabetes mellitus and/or cardiovascular disease. Aims and Objectives: An attempt to find out the association between psoriasis and metabolic disorders by measuring height, weight, body mass index, hip circumference,waist circumference and its ratio, blood pressure and severity of psoriasis patients by PASI (Baseline psoriasis and severity index) score. Further, to investigate each and every patient with complete blood count, fasting and post-prandial blood glucose levels, thyroid profile,lipid profile. Materials: It is a hospital based Case-control study conducted at Department of Dermatology, Venereology and Leprology at Dr.D.Y. Patil Hopsital Nerul, Navi Mumbai for a duration of October 2015 -October 2016 with sample size of 100 patients of Psoriasis along with 100 patients of controls. Informed consent was taken from patients to satisfy the inclusion criteria with patients clinically diagnosed as psoriasis, above 18 years and those who participated in the study not having psoriasis as the controls with no exclusion criteria. An information sheet was given to all the participating patients. Methods: Ethical committee approval, informed Consent were taken from the patients. Severity of psoriasis by PASI score (Baseline psoriasis and severity index) along with height, weight, waist circumference: hip circumference, body mass index were measured. Investigations carried out in all patients were CBC, FBS, PLBS, Thyroid profile, Lipid profile and results were statistically analyzed at the end of study. RESULTS: Out of 200 patients, The observation was in accordance of psoriasis being associated with metabolic syndrome in 71% cases as compared to 37% controls. Conclusion: The blood pressure, sr. triglycerides, sr. high density lipids, fasting blood sugar were significant in cases as compared to controls satisfying the criteria of Adult Panel Treatment III (ATP III) of Metabolic Disorders.


Assuntos
Síndrome Metabólica/epidemiologia , Psoríase/epidemiologia , Adulto , Estudos de Casos e Controles , Humanos , Prevalência , Qualidade de Vida
4.
Biomed Environ Sci ; 32(7): 477-485, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31331432

RESUMO

OBJECTIVE: The association between lipoprotein (a) [Lp(a)] levels and metabolic syndrome (MetS) remains uncertain, especially in the Asian population. The purpose of this study was to demonstrate the association between Lp(a) levels and MetS in a middle-aged and elderly Chinese cohort. METHODS: A cross-sectional study of 10,336 Chinese adults aged 40 years or older was conducted in Jiading District, Shanghai, China. Logistic regression analysis was used to evaluate the association between serum Lp(a) levels and MetS. RESULTS: In the overall population, 37.5% of participants had MetS. Compared with individuals in the lowest quartile of serum Lp(a) levels, those in the highest quartile had a lower prevalence of MetS (30.9% vs. 46.9%, P for trend < 0.0001). Multivariate logistic regression analyses showed that compared with participants in the bottom quartile of serum Lp(a) levels, those in the top quartile had decreased odds ratio (OR) for prevalent MetS [multivariate-adjusted OR 0.45 (95% confidence interval 0.39-0.51); P < 0.0001]. Additionally, Lp(a) level was conversely associated with the risk of central obesity, high fasting glucose, high triglycerides, and low HDL cholesterol, but not with hypertension. Stratified analyses suggested that increasing levels of Lp(a) was associated with decreased risk of MetS in all the subgroups. CONCLUSION: Serum Lp(a) level was inversely associated with the risk of prevalent MetS in a middle-aged and elderly Chinese cohort.


Assuntos
Lipoproteína(a)/sangue , Síndrome Metabólica/sangue , Idoso , Grupo com Ancestrais do Continente Asiático , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade
5.
Isr Med Assoc J ; 21(6): 386-389, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31280506

RESUMO

BACKGROUND: Recently, studies have found that non-alcholic fatty liver disease (NAFLD) is associated with bacterial infections. Attempts to identify risk factors for recurrent urinary tract infections (rUTIs) are still underway. OBJECTIVES: To examine a possible association between NAFLD and rUTIs among premenopausal women. METHODS: In a case-control study, 1009 hospitalized premenopausal women with a UTI during a period of 3 years were retrospectively studied. A total of 186 subjects with rUTIs and 186 controls without a history of rUTIs were included in this study. Each participant had an abdominal ultrasonogram as part of the inclusion criteria. The two groups were compared in terms of risk factors for rUTIs, such as maternal history of rUTIs, use of contraceptives, frequency of sexual intercourse, metabolic syndrome, obesity, use of probiotics, serum levels of vitamin D, and NAFLD. An rUTI was defined as three or more episodes of UTI over a period of 1 year. NAFLD was diagnosed based on abdominal ultrasonography examination. RESULTS: Mean age of the 372 participants was 39.7 ± 5 years. NAFLD was diagnosed in 81/186 subjects (43.5%) with rUTIs vs. 40/186 controls (21.5%), P = 0.05. Women with rUTIs were more often obese and presented with lower serum levels of vitamin D than controls. Multivariate analysis showed that NAFLD (odds ratio = 1.6, 95% confidence interval 1.3-2.0, P = 0.04) were associated with rUTIs in premenopausal women. CONCLUSIONS: NAFLD was associated with rUTI in premenopausal women, independent of metabolic syndrome. Further studies are needed to confirm this association.


Assuntos
Síndrome Metabólica/epidemiologia , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Pré-Menopausa , Infecções Urinárias/epidemiologia , Adulto , Estudos de Casos e Controles , Comorbidade , Feminino , Humanos , Israel/epidemiologia , Recidiva , Estudos Retrospectivos , Fatores de Risco
6.
Int Heart J ; 60(4): 830-835, 2019 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-31257332

RESUMO

Uric acid is associated with cardiovascular disease (CVD) and its risk factors. Here, we examined the association between the serum uric acid level and incident metabolic syndrome in a Japanese general population. This retrospective, observational study was based on data obtained from an annual health checkup program in Gunma Prefecture, Japan. We evaluated 14,793 participants who did not use antihypertensive or antidiabetic medications and did not present with CVD or metabolic syndrome at the study baseline in 2009. Metabolic syndrome was defined as per the Japanese diagnostic criteria. A discrete proportional hazards regression model was used to evaluate the association between the serum uric acid level at baseline and the incident metabolic syndrome through 2012 and was adjusted for age, gender, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, high-density lipoprotein cholesterol, and triglyceride. At baseline, the average age of the participants was 48.9 years, who were comprised of 40% women. The mean serum uric acid level at baseline was 5.3 ± 1.4 mg/dL. During the three-year follow-up, 7% of the cohort (n = 1,031) developed metabolic syndrome. The uric acid level was strongly associated with incident metabolic syndrome in the multivariable model (adjusted hazard ratio: 1.10; 95% confidence interval, 1.04-1.17; P < 0.01 per 1 mg/dL increase for uric acid). Higher uric acid levels were independently associated with a greater risk of incident metabolic syndrome in a Japanese general population.


Assuntos
Síndrome Metabólica/epidemiologia , Vigilância da População , Ácido Úrico/sangue , Biomarcadores/sangue , Feminino , Humanos , Incidência , Japão/epidemiologia , Masculino , Síndrome Metabólica/sangue , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco
8.
Medicine (Baltimore) ; 98(19): e15666, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31083270

RESUMO

The purpose of this observational study was to examine the prevalence of obesity in children of 6 to 8 years of age from primary public schools over a period of 6 years and the associated environmental and metabolic health risk factors.This was a cohort observational study to investigate the prevalence of obesity in children from 14 state primary schools in Vinhedo, Sao Paulo state. Environmental and metabolic health risk factors for obesity were investigated in a cross-sectional survey.This present study revealed 74.0% of children with obesity consumed fried foods and sweets at school, and 84.0% consumed snacks and soft drinks at home. This cohort reported to have engaged in physical activity for less than 3 hours per week at school (93.0%) and at home (85.0%). There was a high prevalence of increased waist circumference and insulin resistance among children with obesity (84.9% and 84.5%, respectively). The body mass index had a significant Spearman correlation with waist circumference, insulin resistance, and triglycerides.Childhood obesity was associated with a high prevalence of both environmental and metabolic risk factors. Also, the authors conclude that the lack of parents' awareness of childhood obesity and its risk factors represents a substantial barrier to lifestyle counseling.


Assuntos
Síndrome Metabólica/epidemiologia , Obesidade Pediátrica/epidemiologia , Índice de Massa Corporal , Brasil/epidemiologia , Criança , Estudos de Coortes , Dieta , Feminino , Humanos , Resistência à Insulina , Masculino , Síndrome Metabólica/patologia , Síndrome Metabólica/fisiopatologia , Pais/psicologia , Obesidade Pediátrica/patologia , Obesidade Pediátrica/fisiopatologia , Prevalência , Fatores de Risco , Instituições Acadêmicas , Comportamento Sedentário , Circunferência da Cintura
9.
Rev Saude Publica ; 53: 44, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31066822

RESUMO

OBJECTIVE: To verify the prevalence of chronic kidney disease and the factors associated to it in older adults (≥ 60 years). METHODS: This is a population-based research conducted in 2014, involving 1,016 older adults living in urban and rural areas of the municipality of Rio Branco, Acre. Chronic kidney disease was defined by glomerular filtration rate < 60 ml/min/1.73 m 2 , estimated by the equations of the Chronic Kidney Disease Epidemiology Collaboration, and the presence of albuminuria > 29 mg/g. Association measure were estimated by gross and adjusted odds ratio (OR), with a confidence level of 95% (95%CI). RESULTS: The overall prevalence of chronic kidney disease was 21.4% in older adults, with the associated factors age, diabetes (OR = 3.39; 95%CI 2.13-5.40), metabolic syndrome (OR = 2.49; 95%CI 1.71-3.63), self-assessment of poor health (OR = 1.79; 95%CI 1.10-2.91), arterial hypertension (OR = 1.82; 95%CI 1.04-3.19) and obesity (OR = 1.69; 95%CI 1.02-2.80). CONCLUSIONS: The prevalence of chronic kidney disease was high in older adults, being associated with age, self-assessment of health as bad or very bad, obesity, diabetes and metabolic syndrome.


Assuntos
Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/etiologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Albuminúria , Brasil/epidemiologia , Creatinina/sangue , Complicações do Diabetes/epidemiologia , Autoavaliação Diagnóstica , Dislipidemias/complicações , Dislipidemias/epidemiologia , Feminino , Taxa de Filtração Glomerular , Humanos , Hipertensão/complicações , Hipertensão/epidemiologia , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/epidemiologia , Prevalência , Fatores de Risco , Fatores Sexuais
10.
Heart Fail Clin ; 15(3): 349-358, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31079693

RESUMO

The interplay between metabolic syndrome (MetS) and heart failure (HF) is intricate. Population studies show that MetS confers an increased risk to develop HF and this effect is mediated by insulin resistance (IR). However, obesity, a key component in MetS and common partner of IR, is protective in patients with established HF, although IR confers an increased risk of dying by HF. Such phenomenon, known as "obesity paradox," accounts for the complexity of the HF-MetS relationship. Because IR impacts more on outcomes than MetS itself, the former may be considered the actual target for MetS in HF patients.


Assuntos
Insuficiência Cardíaca/etiologia , Resistência à Insulina/fisiologia , Síndrome Metabólica/complicações , Saúde Global , Insuficiência Cardíaca/epidemiologia , Humanos , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/metabolismo , Morbidade/tendências , Prognóstico , Fatores de Risco , Taxa de Sobrevida/tendências
11.
BMC Public Health ; 19(1): 535, 2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-31077187

RESUMO

BACKGROUND: Loss of cognitive function is a significant issue as the world's population ages. Preserving cognitive function maintains independence in older adults bringing major societal and financial benefits. Lifestyle factors such as diet are modifiable risk factors, which may help preserve cognitive function. Most nutrition research aimed at preserving cognitive function and metabolic health has focussed on individual nutrients and foods, not allowing for food combinations and interactions. A dietary pattern approach considers the entire diet including its complexity. Previous research investigating dietary patterns and cognitive function has not always considered relevant covariates such as physical activity and the Apolipoprotein E genotype, which are known to have associations with cognitive function. The aim of the REACH (Researching Eating, Activity and Cognitive Health) study is to investigate associations between dietary patterns, cognitive function and metabolic syndrome, accounting for a range of covariates. METHODS: This cross-sectional study design will recruit older, community-living adults (65-74 years) from Auckland, New Zealand. Dietary data will be collected via a 109-item food frequency questionnaire validated using a 4-day food record. Cognitive function will be assessed using the Montreal Cognitive Assessment (paper based) and the Computerised Mental Performance Assessment System (COMPASS) - a testing suite covering six domains. Additional data will include genetic (Apolipoprotein E ε4) and biochemical markers (fasting glucose, HbA1c, lipids profile), anthropometric measurements (weight, height, waist and hip circumference, body composition using dual X-ray absorptiometry), blood pressure, physical activity (International Physical Activity Questionnaire - short form) and health and demographics (questionnaire). Dietary patterns will be derived by principal component analysis. Associations between cognitive function and dietary patterns will be examined using multiple regression analysis. Covariates and interaction factors will include age, education, socio-economic status, physical activity, Apolipoprotein E ε4 genotype, family history of dementia or cognitive impairment, and lifestyle factors. Differences between participants with and without metabolic syndrome will also be examined. DISCUSSION: This study will bring new knowledge regarding associations between dietary patterns and cognitive function and metabolic health in older adults living in New Zealand. This is important for developing nutrition related recommendations to help older adults maintain cognitive function.


Assuntos
Disfunção Cognitiva/epidemiologia , Dieta/estatística & dados numéricos , Exercício , Estilo de Vida , Síndrome Metabólica/epidemiologia , Idoso , Peso Corporal , Cognição/fisiologia , Disfunção Cognitiva/psicologia , Estudos Transversais , Dieta/psicologia , Fenômenos Fisiológicos da Nutrição do Idoso , Feminino , Preferências Alimentares , Humanos , Masculino , Síndrome Metabólica/psicologia , Nova Zelândia , Fatores de Risco , Inquéritos e Questionários
12.
Orthop Nurs ; 38(3): 201-208, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31124872

RESUMO

BACKGROUND: Rheumatic disease and gout are particularly known to be associated with metabolic syndrome. PURPOSE: To compare incidence, physiological indices, and risk factors of metabolic syndrome in patients with rheumatic diseases or gout. METHODS: Data were collected from medical records of 220 patients with rheumatic disease or gout. RESULTS: The incidence rate and most physiological indices of metabolic syndrome (body mass index, blood pressure, serum triglyceride, and fasting blood glucose levels) were significantly higher in the gout group than in the rheumatic disease group. In terms of risk factors of metabolic syndrome, age, gender, and steroid use were significant in the rheumatic disease group, whereas smoking and gout duration were significant in the gout group. CONCLUSIONS: Men with a rheumatic disease taking steroids warrant additional attention regarding metabolic syndrome development. Special supports are also needed for people with gout who are smokers and who have suffered from gout for a longer duration.


Assuntos
Gota/etiologia , Incidência , Síndrome Metabólica/complicações , Doenças Reumáticas/etiologia , Adulto , Idoso , Análise de Variância , Índice de Massa Corporal , Feminino , Gota/epidemiologia , Gota/fisiopatologia , Humanos , Masculino , Síndrome Metabólica/classificação , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Projetos de Pesquisa/normas , Doenças Reumáticas/epidemiologia , Doenças Reumáticas/fisiopatologia , Fatores de Risco
14.
Actas dermo-sifiliogr. (Ed. impr.) ; 110(4): 279-288, mayo 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-180900

RESUMO

En recientes estudios se ha demostrado la existencia de una relación entre la hidradenitis supurativa (HS) y el síndrome metabólico (SM), sin embargo, hasta el momento no se ha realizado ningún metaanálisis que incluya estudios ajustados según variables de confusión. Objetivos: Determinar la asociación entre la HS y el SM. Metodología: Se realizó una revisión sistemática y un metaanálisis, donde se incluyeron estudios observacionales acerca de la HS y el SM en pacientes adultos, localizados en MEDLINE, SCOPUS, SCIELO, GOOGLE SCHOLAR, SCIENCE DIRECT y LILACS, y que fueron publicados en un periodo comprendido entre el inicio de la base de datos hasta enero del 2016. De esta manera, se realizó un metaanálisis, para el cual se siguió el modelo de efectos aleatorios basándose en aquellos estudios con odds ratios (OR) ajustadas y crudas y que además presentaban un intervalo de confianza (IC) del 95%. El subgrupo analizado se correlacionó posteriormente con el tipo de población con HS (población general con HS vs. población hospitalaria con HS) y con el grupo de edad (adultos vs. niños y adultos). Resultados: Cinco estudios, incluyendo 3.950 pacientes con HS fueron analizados. Se encontró que el SM estaba presente en el 9,64% de los pacientes con HS (OR 1,82, IC del 95%, 1,39-2,25). Estudios realizados en centros dermatológicos hospitalarios de tercer nivel (OR 2,82, IC del 95%, 0,58-5,06) mostraron una mayor asociación al SM comparados con estudios realizados en la población general (OR 1,78, IC del 95%, 1,34-2,22). Los estudios que incluyeron una población pediátrica registraron así mismo una asociación significativa al SM (OR 2,10, IC del 95%, 1,58-2,62). Limitación: Se contó con escasos estudios ajustados a las variables de confusión. Conclusión: Los pacientes con HS tendrán un riesgo incrementado de presentar SM. Se debería considerar la realización de un cribado de factores de riesgo metabólicos en todos los pacientes con HS


Background: Recent studies have shown a relationship between hidradenitis suppurativa (HS) and metabolic syndrome (MS), but the literature offers no meta-analysis restricted to studies that have been adjusted for confounders. Objective: To determine the association between HS and MS. Methods: A systematic review and meta-analysis of observational studies on HS and MS in adults. We searched MEDLINE, SCOPUS, SCIELO, Google Scholar, Science Direct, and LILACS from the inception of the databases to January 2016. We performed a random effects model meta-analysis for studies reporting adjusted and crude odds ratios (ORs) with 95% CIs. A subgroup analysis was related to the type of HS patient (general patients vs hospital patients) and age group (adults vs children and adults). Results: Five studies including 3950 HS patients were analyzed. We found that MS was present in 9.64% of HS patients (OR, 1.82; 95%, CI 1.39-2.25). Studies from tertiary care hospital dermatology clinics (OR, 2.82; 95% CI, 0.58-5.06) reported a greater risk for MS than studies carried out in patients treated outside hospitals (OR, 1.78; 95% CI, 1.34-2.22). Studies that included pediatric populations reported a significant association (OR, 2.10; 95% CI, 1.58-2.62). Limitation: Few of the included studies reported adjusted ORs. Conclusions: HS patients have an increased risk for MS. Clinicians should consider screening HS patients for metabolic risk factors


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Hidradenite Supurativa/complicações , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/etiologia , Fatores de Confusão (Epidemiologia) , Estudos Prospectivos , Estudos Retrospectivos , Estudos Observacionais como Assunto , Criança , Fumantes
15.
J Ayub Med Coll Abbottabad ; 31(2): 252-254, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31094127

RESUMO

Metabolic syndrome (MetS) is clustering of various cardiometabolic risk factors and it increases the risk of cardiovascular diseases and diabetes. Unhealthy lifestyle predisposes employees to increased risk of MetS. This systematic review was conducted to investigate the prevalence of MetS and its associated factors among working population. Studies published in English during 2005-2017 on the prevalence of MetS in workforce were searched. MetS was defined using Adult Treatment Panel-III criteria and searches were carried out in various databases using keywords for titles and/or abstracts. Forty articles, containing 435,013 participants aged 38.5 (18-64) years, were finally included. Overall average prevalence of MetS was 21.7% (6.1-58%). Average prevalence of MetS was higher in males (21.9%) than in females (14.1%). Region-wise prevalence of MetS was 27.93% in North America, 27.65% in South America, 21.27% in Asia, 16.04% in Africa, and 10.47% in Europe. Mean prevalence of each component of MetS was 39.1% for low HDL, 33.7% for hypertension, 30.8% for hypertriglyceridemia, 29.2% for central obesity, and 17.6% for hyperglycaemia. Major factors associated with MetS were male gender, aging, inactivity, smoking, stress, elevated liver enzymes, higher education, longer work experience, alcohol abuse, shift work, and lower fruit intake. Prevalence of MetS among workforce was high and it decreases work performance and increases personal and corporate health-care cost. Employees are suggested to enhance physical activity and adopt healthy lifestyle. Employers may increase the cardiometabolic health of their employees by increasing awareness, routine screening for MetS, and by providing various health promotion programs at the worksite.


Assuntos
Síndrome Metabólica/epidemiologia , Recursos Humanos/estatística & dados numéricos , Adolescente , Adulto , Feminino , Humanos , Hiperglicemia/epidemiologia , Hipertensão/epidemiologia , Hipertrigliceridemia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
16.
Adv Exp Med Biol ; 1160: 35-41, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31041698

RESUMO

Metabolic syndrome (MetS) and obstructive sleep apnea (OSA) are related to a higher incidence of cardio-vascular diseases and mortality in patients. The aim of the study was to define the potential use of anthropometric factors for the evaluation of OSA risk in patients with diagnosed MetS. The patient group consisted of 50 obese men with MetS (mean age 49 ± 9 years). The following anthropometric indices were assessed: body mass index (BMI), neck circumference (NC), waist circumference (WC), and waist-to-hip ratio (WHR). In addition, blood glucose and lipid profile were investigated. On the basis of polysomnography, clinical symptoms, and Epworth Sleep Scale, patients were stratified into the OSA group accompanied by MetS (n = 31) and the MetS alone group taken as control (n = 19). OSA was evaluated as severe in 26 out of the 31 patients (>30 apneic episodes per hour). We found a significantly larger NC in the OSA with MetS group then that in the MetS alone group. Further, NC associated with the increase in the apnea/hypopnea index. However, the other anthropometric indices investigated failed to differentiate the two groups. We conclude that increased neck circumference in patients suffering from metabolic syndrome is a risk factor for the development of OSA.


Assuntos
Síndrome Metabólica , Apneia Obstrutiva do Sono , Adulto , Antropometria , Índice de Massa Corporal , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/etiologia , Pessoa de Meia-Idade , Pescoço/anatomia & histologia , Fatores de Risco , Apneia Obstrutiva do Sono/complicações , Circunferência da Cintura , Relação Cintura-Quadril
17.
Int J Mol Sci ; 20(9)2019 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-31064058

RESUMO

With the progressive epidemics of obesity, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in adults and children. The increasing prevalence and incidence of NAFLD with advanced fibrosis is concerning because patients appear to experience higher non-liver-related morbidity and mortality than the general population. Recent clinical evidence suggests that NAFLD is directly associated with an increased risk of cardio-metabolic disorders. This mini review describes briefly the current understanding of the pathogenesis of NAFLD, summarizing the link between NAFLD and cardio-metabolic complications, focusing mainly upon ischemic stroke, type 2 diabetes mellitus (DM), hypertension, chronic kidney disease (CKD) and cardiac arrhythmias. In addition, it describes briefly the current understanding of the pathogenesis of NAFLD.


Assuntos
Doenças Cardiovasculares/epidemiologia , Síndrome Metabólica/epidemiologia , Hepatopatia Gordurosa não Alcoólica/complicações , Doenças Cardiovasculares/etiologia , Humanos , Síndrome Metabólica/etiologia , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Hepatopatia Gordurosa não Alcoólica/etiologia
18.
High Blood Press Cardiovasc Prev ; 26(3): 191-197, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31041682

RESUMO

The atherosclerotic alterations that are the basis of cardiovascular diseases can start already in childhood. For this reason the prevention of cardiovascular diseases should be undertaken very early both in the general population and, in a targeted manner, in subjects at cardiovascular risk. Preventive strategies should include measures to encourage physical activity and correct eating habits and to reduce exposure to pollutants. The main actors responsible for carrying out these preventive interventions are the local and national political authorities. Moreover, particular attention should be paid to the first thousand days of life starting from conception, to prevent unfavorable epigenetic modifications. In addition to initiatives aimed at the general population, interventions should be planned by the medical community to assess the individual risk profile. The current obesity epidemic has in fact made it relatively frequent even among children and adolescents to find some cardiovascular risk factors known in adults such as arterial hypertension, dyslipidemia, glucose metabolism disorders and increased of uric acid values. The purpose of this review is to indicate lines of intervention for cardiovascular prevention in children and adolescents.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Síndrome Metabólica/terapia , Serviços Preventivos de Saúde/métodos , Adolescente , Idade de Início , Pressão Arterial , Biomarcadores/sangue , Glicemia/metabolismo , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/fisiopatologia , Criança , Comorbidade , Dislipidemias/sangue , Dislipidemias/epidemiologia , Dislipidemias/terapia , Transtornos do Metabolismo de Glucose/sangue , Transtornos do Metabolismo de Glucose/epidemiologia , Transtornos do Metabolismo de Glucose/terapia , Nível de Saúde , Humanos , Hipertensão/epidemiologia , Hipertensão/fisiopatologia , Hipertensão/terapia , Hiperuricemia/sangue , Hiperuricemia/epidemiologia , Hiperuricemia/terapia , Lipídeos/sangue , Síndrome Metabólica/sangue , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/fisiopatologia , Obesidade Pediátrica/epidemiologia , Obesidade Pediátrica/fisiopatologia , Obesidade Pediátrica/terapia , Fatores de Proteção , Fatores de Risco , Ácido Úrico/sangue , Ganho de Peso
19.
Minerva Med ; 110(5): 410-418, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31081301

RESUMO

BACKGROUND: Patients with acute coronary syndrome (ACS) and previous cardiovascular disease (CVD) (stroke, peripheral arterial disease [PAD] or coronary artery disease [CAD]) are at high risk of serious events and mortality. Current clinical guidelines recommend new antiplatelet drugs (NADs) for high cardiovascular risk patients with ACS; however, these drugs are underused in different scenarios. METHODS: This study included 1717 ACS patients from 3 tertiary hospitals. Of them, 641 (37.33%) suffered from previous CVD: 149 patients with stroke, 154 patients with PAD and 541 patients with CAD. Bleeding, mortality and major adverse cardiac events (MACE) at 1 year of follow-up after hospital discharge were analyzed. RESULTS: NADs administration during hospital stay and at discharge was less frequent in patients with previous CVDs (P<0.001, for both). Cox analysis in this cohort of patients showed that clopidogrel prescription at discharge was independently associated with MACEs (HR: 1.59 [95% CI: 1.03-2.45]; P=0.036) and with death (HR: 1.99 [95% CI: 1.00-3.98]; P=0.049) in multivariate analysis. More specifically, when ticagrelor prescription at discharge was compared with clopidogrel, a significant death reduction was found in both, the univariate and the multivariate Cox analysis (HR: 4.54 [95% CI: 2.26-9.13]; P<0.001 and HR: 2.61 [95% CI: 1.16-5.90]; P=0.021, respectively). CONCLUSIONS: New antiplatelet drugs, especially ticagrelor, showed lower rates of mortality in patients with CVD without differences for bleeding. Despite the recommendations of current clinical guidelines for high risk patients with ACS, the use of NADs is very low in "real-life" patients with previous CVD.


Assuntos
Síndrome Coronariana Aguda/tratamento farmacológico , Doença das Coronárias/complicações , Doença Arterial Periférica/complicações , Inibidores da Agregação de Plaquetas/uso terapêutico , Acidente Vascular Cerebral/complicações , Síndrome Coronariana Aguda/etiologia , Síndrome Coronariana Aguda/mortalidade , Assistência ao Convalescente , Clopidogrel/efeitos adversos , Clopidogrel/uso terapêutico , Comorbidade , Uso de Medicamentos/estatística & dados numéricos , Feminino , Seguimentos , Hemorragia/induzido quimicamente , Hemorragia/epidemiologia , Humanos , Estimativa de Kaplan-Meier , Masculino , Síndrome Metabólica/epidemiologia , Inibidores da Agregação de Plaquetas/efeitos adversos , Cloridrato de Prasugrel/uso terapêutico , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fumar/epidemiologia , Espanha , Centros de Atenção Terciária/estatística & dados numéricos , Ticagrelor/efeitos adversos , Ticagrelor/uso terapêutico
20.
BMC Public Health ; 19(1): 613, 2019 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-31113427

RESUMO

BACKGROUND: Several epidemiological studies have suggested that optimal obesity and visceral adiposity indicators and their cut-off values to predict cardio-metabolic risks varied among different ethnic groups. However, few studies have investigated the associations of anthropometric indices with cardio-metabolic risks in Chinese Uyghur adults, and the results were inconsistent. METHODS: Between May and September 2016, a total of 4664 subjects aged ≥18 years old were recruited from Northwest China. Anthropometric indices and cardio-metabolic risk factors were measured by trained personnel. Partial correlation analyses and logistic regression analyses were used to evaluate the associations of anthropometric indices with cardio-metabolic risk factors. Receiver operating characteristic analysis was used to compare the abilities of different anthropometric indices to predict cardio-metabolic risk factors, and to determine the optimal cut-off values. RESULTS: The prevalence of metabolic syndrome was 39.41% in Uyghur adults from Xinjiang Uyghur Autonomous Region. Waist circumference (WC) performed better than other obesity indices in predicting the cardio-metabolic risk factors, and the optimal cut-off value of WC to diagnose metabolic syndrome risk factors was 86.50 cm for women and 90.50 cm for men. CONCLUSIONS: Our study suggests that WC had the strongest predictive power for identifying cardio-metabolic risks in Xinjiang Uyghur adults. Further well-designed longitudinal studies are needed to confirm our findings.


Assuntos
Doenças Cardiovasculares/diagnóstico , Síndrome Metabólica/diagnóstico , Circunferência da Cintura , Adulto , Antropometria , Doenças Cardiovasculares/epidemiologia , China/epidemiologia , Feminino , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prevalência , Valores de Referência , Fatores de Risco
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