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1.
J Sci Food Agric ; 100(1): 225-234, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31512247

RESUMO

BACKGROUND: Metabolic syndrome, a group of factors that increase the risk of health problems, is becoming increasingly common. Strategies to prevent metabolic syndrome have received substantial attention. Black tea consumption and selenium (Se) intake have been reported to be associated negatively with the prevalence of metabolic syndrome. We therefore sought to investigate whether Se-rich black tea might have a stronger effect than Se-deficient black tea in the prevention of metabolic syndrome. RESULTS: Sprague-Dawley rats were divided into four groups and fed a normal rodent diet, high-fat diet, high-fat diet containing 3% Se-rich black tea, or a high-fat diet containing 3% Se-deficient black tea for 4 weeks. Blood and tissue samples were tested at the end of the experiment. The results suggested that both types of black tea ameliorated high-fat diet-induced body-weight gain, lowered serum triglycerides and attenuated intestinal barrier dysfunction. Selenium-rich black tea showed stronger activity in decreasing fasting serum glucose and increasing insulin sensitivity, as well as stronger hepatoprotection, owing to higher total antioxidant capacity and activated hepatic antioxidant enzymes. However, it did not exhibit better effects in preventing fat accumulation. The different effects of Se-rich and Se-deficient black tea on the gut microbiota might have been partially responsible for the results. CONCLUSION: Compared with Se-deficient black tea, Se-rich black tea displayed stronger activity in preventing high-fat diet-induced hyperglycemia and liver damage but was not better at preventing fat accumulation and attenuating dysbiosis. More experiments are needed to understand the underlying mechanisms further. © 2019 Society of Chemical Industry.


Assuntos
Camellia sinensis/química , Síndrome Metabólica/prevenção & controle , Selênio/análise , Chá/metabolismo , Animais , Glicemia/metabolismo , Camellia sinensis/metabolismo , Dieta Hiperlipídica/efeitos adversos , Jejum , Humanos , Resistência à Insulina , Masculino , Síndrome Metabólica/etiologia , Síndrome Metabólica/metabolismo , Ratos , Ratos Sprague-Dawley , Selênio/metabolismo , Chá/química
2.
J Agric Food Chem ; 68(3): 788-798, 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-31852192

RESUMO

Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced MetS. Seed meals from two Camelina sativa lines enriched, respectively, in C24- and C16-NH2- glycosyl-inositol-phosphoryl-ceramides (NH2GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH2GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH2GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels. Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length.


Assuntos
Camellia/química , Mucosa Intestinal/metabolismo , Síndrome Metabólica/prevenção & controle , Extratos Vegetais/metabolismo , Esfingolipídeos/metabolismo , Ração Animal/análise , Animais , Dieta Hiperlipídica/efeitos adversos , Humanos , Masculino , Síndrome Metabólica/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Extratos Vegetais/química , Esfingolipídeos/química
3.
Clin Ter ; 170(5): e364-e367, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31612194

RESUMO

In the last 40 years, the number of elderly patients that require Assisted Reproductive Technologies (ART) has risen enormously, especially after heterolougus fertilization techniques have become available. In recent years, the incidence of peripartum cardiomyopathy (PPCM) has substantially grown, as a consequence of the combined effect of increased maternal age, consequent high prevalence of hypertension and metabolic syndrome (MS). That cohort of women may be exposed to a greater number of cardiac, obstetric and anesthesio-logical complications, therefore the incidence of medico-legal issues, litigation, liabilities and claims over the past years has significantly risen. Cardiovascular and hormonal changes during pregnancy can challenge even the healthiest of individuals, and in that pregnant population the risk is even greater. These patients should be monitored before the ART, during pregnancy, delivery and puerperium, to avoid heart failure, thrombotic problems, embolic complications, stroke and death. Management issues regarding pregnancy and delivery are elaborate, including anesthesia considerations. This new population of women needs an accurate cardiac risk stratification with a thorough cardiovascular history and examination, 12 lead ECG, and transthoracic echocardiogram. Therefore, a comprehensive multidisciplinary assessment and management can provide the best opportunity to improve maternal and neonatal outcomes.


Assuntos
Síndrome Metabólica/etiologia , Complicações Cardiovasculares na Gravidez/etiologia , Técnicas de Reprodução Assistida/legislação & jurisprudência , Adulto , Fatores Etários , Idoso , Feminino , Humanos , Síndrome Metabólica/prevenção & controle , Gravidez , Complicações Cardiovasculares na Gravidez/prevenção & controle , Gestantes , Técnicas de Reprodução Assistida/efeitos adversos , Fatores de Risco
4.
Life Sci ; 237: 116905, 2019 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-31610198

RESUMO

AIMS: The prevalence of metabolic syndrome (MetS) is increasing in several countries. The MetS is characterized by the occurrence of at least three of the following risk factors: decreased high-density lipoprotein cholesterol, increased blood pressure, raised fasting blood glucose, elevated triglycerides, and abdominal obesity. There is a growing evidence of the role of l-carnosine in improving lipid profile and enhancement of the antioxidant activity. However, the effects of l-carnosine on development of MetS are unknown. MAIN METHODS: Male Wistar rats were randomly assigned to receive either; conventional diet (control), high-fat high-carbohydrate diet (HFHCD), l-carnosine and conventional diet (L-Car), or l-carnosine and high-fat high-carbohydrate diet (HFHCD and L-Car) for 16 weeks. Central obesity, systolic blood pressure, lipid profile, glucose hemostasis, levels of leptin and adiponectin were evaluated on week 16. KEY FINDINGS: Rats that received HFHCD for 16 weeks showed MetS phenotype such as central obesity, increased blood pressure and glucose, as well as an altered lipid profile (P < 0.05). l-Carnosine supplementation to MetS rats significantly reduced abdominal obesity, blood pressure and glucose, and normalized total cholesterol and low density lipoprotein cholesterol levels (P < 0.05). Insulin, leptin and adiponectin concentrations were not affected by l-Carnosine (P > 0.05). SIGNIFICANCE: l-carnosine has beneficial effects on ameliorating the manifestations of MetS in rats.


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Carnosina/administração & dosagem , Dieta da Carga de Carboidratos/efeitos adversos , Dieta Hiperlipídica/efeitos adversos , Lipídeos/sangue , Síndrome Metabólica/prevenção & controle , Animais , Glicemia/análise , Resistência à Insulina , Masculino , Síndrome Metabólica/etiologia , Ratos , Ratos Wistar
5.
Endocrinology ; 160(12): 2787-2799, 2019 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-31593246

RESUMO

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and ovulatory dysfunction. Women with PCOS have an elevated prevalence of cardiometabolic risk factors that worsen after menopause. Liraglutide (Lira), a glucagon-like peptide-1 receptor agonist, has shown beneficial metabolic effects in small clinic trials in reproductive-age women with PCOS. We have shown that chronic hyperandrogenemia in an experimental model of postmenopausal PCOS is associated with an adverse cardiometabolic profile and upregulation of the intrarenal renin-angiotensin system (RAS). We analyzed the effect of Lira in the cardiometabolic profile, intrarenal RAS, and blood pressure (BP) in postmenopausal PCOS. Four-week-old female Sprague Dawley rats were treated with DHT or placebo for 17 months. Lira administration during the last 3 weeks caused a bigger reduction in food intake, body weight, fat mass, and homeostasis model assessment of insulin resistance index in PCOS than in control rats. Moreover, Lira improved dyslipidemia and elevated leptin levels in PCOS. In contrast, Lira decreased intrarenal expression of RAS components only in the control group. Lira transiently increased heart rate and decreased BP in control rats. However, Lira did not modify BP but increased heart rate in PCOS. The angiotensin-converting-enzyme inhibitor enalapril abolished the BP differences between PCOS and control rats. However, Lira coadministration with enalapril further reduced BP only in control rats. In summary, Lira has beneficial effects for several cardiometabolic risk factors in postmenopausal PCOS. However, hyperandrogenemia blunted the BP-lowering effect of Lira in postmenopausal PCOS. Androgen-induced activation of intrarenal RAS may play a major role mediating increases in BP in postmenopausal PCOS.


Assuntos
Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas , Hiperandrogenismo/complicações , Liraglutida/uso terapêutico , Síndrome Metabólica/prevenção & controle , Síndrome do Ovário Policístico/complicações , Animais , Pressão Sanguínea/efeitos dos fármacos , Composição Corporal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Ingestão de Alimentos/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Resistência à Insulina , Leptina/sangue , Lipídeos/sangue , Liraglutida/farmacologia , Síndrome Metabólica/etiologia , Pós-Menopausa , Distribuição Aleatória , Ratos Sprague-Dawley , Sistema Renina-Angiotensina/efeitos dos fármacos
6.
Nat Commun ; 10(1): 4291, 2019 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-31541116

RESUMO

Supplementation with the NAD+ precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously shown that NR kinase 1 (NRK1) is rate-limiting and essential for NR-induced NAD+ synthesis in hepatic cells. To understand the relevance of hepatic NR metabolism, we generated whole body and liver-specific NRK1 knockout mice. Here, we show that NRK1 deficiency leads to decreased gluconeogenic potential and impaired mitochondrial function. Upon high-fat feeding, NRK1 deficient mice develop glucose intolerance, insulin resistance and hepatosteatosis. Furthermore, they are more susceptible to diet-induced liver DNA damage, due to compromised PARP1 activity. Our results demonstrate that endogenous NR metabolism is critical to sustain hepatic NAD+ levels and hinder diet-induced metabolic damage, highlighting the relevance of NRK1 as a therapeutic target for metabolic disorders.


Assuntos
Dieta Hiperlipídica/efeitos adversos , Hepatopatias/prevenção & controle , Niacinamida/análogos & derivados , Fosfotransferases (Aceptor do Grupo Álcool)/genética , Substâncias Protetoras/metabolismo , Substâncias Protetoras/farmacologia , Animais , Glicemia , Dano ao DNA , Modelos Animais de Doenças , Técnicas de Inativação de Genes , Predisposição Genética para Doença/genética , Intolerância à Glucose , Hepatócitos/metabolismo , Resistência à Insulina , Metabolismo dos Lipídeos , Fígado/metabolismo , Hepatopatias/genética , Hepatopatias/patologia , Masculino , Síndrome Metabólica/genética , Síndrome Metabólica/prevenção & controle , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , NAD/metabolismo , Niacinamida/genética , Niacinamida/metabolismo , Niacinamida/farmacologia
7.
Diabetes Metab Syndr ; 13(4): 2689-2697, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31405695

RESUMO

BACKGROUND: The metabolic syndrome (Metabolic syndrome) is a cluster of the most dangerous risk factors for type 2 diabetes mellitus and cardiovascular diseases (CVD), two of the main causes of morbidity and mortality worldwide, which include hyperglycemia, abdominal obesity, lipid abnormalities and high blood pressure. STUDY DESIGN: a cross-sectional descriptive study. RESULTS: A predominant number (94.1%) knew what constitutes MS. However, merely more than a quarter of the participant (28%) knew correctly the serum LDL cutoff value for the diagnosis of MS according to IDF criteria. The aim of lipid lowering treatment was known by slightly more than three fourth (78%) of the participants. Two third also knew the target of antihypertensive therapy. More than two third (69.5%) were also aware that waist circumference is one of the criteria for diagnosis of Metabolic syndrome. CONCLUSION: There is a need to increase the awareness of MS among the PHC Physicians. More training programs need to be planned. A better awareness among primary care physician is warranted for an early diagnosis and effective management of MS in Saudi Arabia.


Assuntos
Biomarcadores/análise , Conhecimentos, Atitudes e Prática em Saúde , Programas de Rastreamento , Síndrome Metabólica/diagnóstico , Síndrome Metabólica/prevenção & controle , Médicos de Atenção Primária/estatística & dados numéricos , Padrões de Prática Médica/estatística & dados numéricos , Adulto , Atitude do Pessoal de Saúde , Estudos Transversais , Gerenciamento Clínico , Feminino , Seguimentos , Humanos , Masculino , Médicos de Atenção Primária/psicologia , Médicos de Atenção Primária/normas , Projetos Piloto , Prognóstico , Arábia Saudita , Inquéritos e Questionários
8.
Nutrients ; 11(8)2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31434293

RESUMO

Lifestyle is a well-known environmental factor that plays a major role in facilitating the development of metabolic syndrome or eventually exacerbating its consequences. Various lifestyle factors, especially changes in dietary habits, extreme temperatures, unusual light-dark cycles, substance abuse, and other stressful factors, are also established modifiers of the endocannabinoid system and its extended version, the endocannabinoidome. The endocannabinoidome is a complex lipid signaling system composed of a plethora (>100) of fatty acid-derived mediators and their receptors and anabolic and catabolic enzymes (>50 proteins) which are deeply involved in the control of energy metabolism and its pathological deviations. A strong link between the endocannabinoidome and another major player in metabolism and dysmetabolism, the gut microbiome, is also emerging. Here, we review several examples of how lifestyle modifications (westernized diets, lack or presence of certain nutritional factors, physical exercise, and the use of cannabis) can modulate the propensity to develop metabolic syndrome by modifying the crosstalk between the endocannabinoidome and the gut microbiome and, hence, how lifestyle interventions can provide new therapies against cardiometabolic risk by ensuring correct functioning of both these systems.


Assuntos
Endocanabinoides/fisiologia , Estilo de Vida , Síndrome Metabólica , Animais , Canabinoides/uso terapêutico , Dieta , Dieta Hiperlipídica/efeitos adversos , Fibras na Dieta , Exercício , Microbioma Gastrointestinal/fisiologia , Humanos , Síndrome Metabólica/etiologia , Síndrome Metabólica/fisiopatologia , Síndrome Metabólica/prevenção & controle , Necessidades Nutricionais , Receptores de Canabinoides , Transdução de Sinais , Vitamina D/fisiologia
9.
Nutrients ; 11(8)2019 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-31382417

RESUMO

The metabolic syndrome (MetS) is a group of cardiovascular risk factors that are associated with insulin resistance and are driven by underlying factors, including visceral obesity, systemic inflammation, and cellular dysfunction. These risks increasingly begin in childhood and adolescence and are associated with a high likelihood of future chronic disease in adulthood. Efforts should be made at both recognition of this metabolic risk, screening for potential associated Type 2 diabetes, and targeting affected individuals for appropriate treatment with an emphasis on lifestyle modification. Effective interventions have been linked to reductions in MetS-and in adults, reductions in the severity of MetS have been linked to reduced diabetes and cardiovascular disease.


Assuntos
Síndrome Metabólica/diagnóstico , Adolescente , Doenças Cardiovasculares/prevenção & controle , Criança , Diabetes Mellitus Tipo 2/prevenção & controle , Dieta , Exercício , Humanos , Inflamação , Resistência à Insulina , Estilo de Vida , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/prevenção & controle , Obesidade Pediátrica/epidemiologia , Obesidade Pediátrica/prevenção & controle , Fatores de Risco
10.
Nutrients ; 11(7)2019 Jul 19.
Artigo em Inglês | MEDLINE | ID: mdl-31331009

RESUMO

Both observational and interventional studies suggest an important role for physical activity and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic syndrome is, to a certain extent, favorably influenced by interventions that include physical activity. Given that the prevalence of the metabolic syndrome and its individual components (particularly obesity and insulin resistance) has increased significantly in recent decades, guidelines from various professional organizations have called for greater efforts to reduce the incidence of this condition and its components. While physical activity interventions that lead to improved fitness cannot be expected to normalize insulin resistance, lipid disorders, or obesity, the combined effect of increasing activity on these risk markers, an improvement in fitness, or both, has been shown to have a major impact on health outcomes related to the metabolic syndrome. Exercise therapy is a cost-effective intervention to both prevent and mitigate the impact of the metabolic syndrome, but it remains underutilized. In the current article, an overview of the effects of physical activity and higher fitness on the metabolic syndrome is provided, along with a discussion of the mechanisms underlying the benefits of being more fit or more physically active in the prevention and treatment of the metabolic syndrome.


Assuntos
Aptidão Cardiorrespiratória/fisiologia , Exercício/fisiologia , Síndrome Metabólica/epidemiologia , Adulto , Doenças Cardiovasculares/prevenção & controle , Feminino , Humanos , Resistência à Insulina/fisiologia , Masculino , Síndrome Metabólica/prevenção & controle , Síndrome Metabólica/terapia , Pessoa de Meia-Idade , Obesidade/terapia , Aptidão Física/fisiologia , Fatores de Risco
11.
Diabetes Metab Syndr ; 13(2): 1187-1191, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31336463

RESUMO

It has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic variant. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) pathologies still remains elusive. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 allele variant, also known as the Alzheimer's disease gene, are primarily at a greater risk for physiological consequences, specifically cognitive impairment (Chan et al., 2016). In this case study, a 71-year old female, heterozygous for ApoE4 with a family history of Alzheimer's Disease (AD) and the dual diagnosis of mild AD/metabolic syndrome (MetS) was placed on a 10-week nutrition protocol purposed at raising plasma ketones through carbohyrdrate restricted, high fat ketogenic diet (KD), time- restricted eating and physical/cognitive exercise. Primary biomarkers for MetS were measured pre/mid-/post intervention. The MoCA (Montreal Cognitive Assessment) was administered pre/post intervention by a licensed clinical therapist. The results were statistically significant. The HOMA-IR decreased by 75% from 13.9 to 3.48. Triglycerides decreased by 50% from 170mg/dL to 85mg/dL. VLDL dropped by 50% from 34mg/dL to 17mg/dL, and HgA1c decreased from 5.7% to 4.9%. The baseline MoCA score was 21/30; post treatment score was 28/30. The significant results in both MetS biomarkers and the MoCA score suggest that a ketogenic diet may serve to rescue cognition in patients with mild AD. The results of this case study are particularly compelling for ApoE4 positive (ApoE4+) subjects as ketogenic protocols extend hope and promise for AD prevention.


Assuntos
Doença de Alzheimer/complicações , Apolipoproteína E4/genética , Disfunção Cognitiva/prevenção & controle , Dieta Cetogênica/métodos , Variação Genética , Síndrome Metabólica/prevenção & controle , Idoso , Biomarcadores/análise , Disfunção Cognitiva/etiologia , Disfunção Cognitiva/patologia , Feminino , Humanos , Síndrome Metabólica/etiologia , Síndrome Metabólica/patologia , Prognóstico
12.
Diabetes Metab Syndr ; 13(2): 1359-1364, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31336492

RESUMO

PURPOSE: To compare the acute and chronic effects of high-intensity intermittent training (HIIT) and moderate-intensity continuous training (MICT) on indices of cardio-metabolic health: (HDL-c, total cholesterol, triglycerides, heart ratio, and phase angle/PhA) in physically active men. METHODS: Twenty active men were randomly allocated to HIIT (n = 10), or MICT (n = 10) for 5 weeks, three times per week. HIIT consisted of running 5 km with 1-min at 100% of maximal aerobic speed interspersed by 1-min passive recovery while subjects in MICT group ran continuously the same 5 km at 70% of maximal aerobic speed. Blood samples were collected at different moments during the first and last exercise session. Before and after 5 weeks of both exercise training protocols, heart ratio (during exercise session) and PhA were measured pre and post-exercise training. RESULTS: Fasting HDL-c levels did not change after 5 weeks of HIIT or MICT. Perceptual variation of HDL pre and post training (fed state) tended to differ between HIIT and MICT (p = 0.09). All lipoproteins parameters (HDL-c, total cholesterol, triglycerides and non-HDL) were increased in post-acute exercise session compared to pre-exercise during the first and last training session, these being observed after both training protocols. PhA and heart rate measured at different times during the first and last training session were not affected in both training protocols. CONCLUSION: These results indicate that HIIT and MICT modify the post-exercise lipoprotein profile acutely. On the other hand, only HIIT tended to increase HDL-c levels chronically.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Exercício , Treinamento Intervalado de Alta Intensidade/métodos , Síndrome Metabólica/prevenção & controle , Adulto , Biomarcadores/análise , Seguimentos , Frequência Cardíaca , Humanos , Masculino , Prognóstico , Fatores de Tempo
13.
Int J Mol Sci ; 20(15)2019 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-31357643

RESUMO

Obesity causes various health problems, such as type 2 diabetes, non-alcoholic fatty liver disease, and cardio- and cerebrovascular diseases. Metabolic organs, particularly white adipose tissue (WAT) and liver, are deeply involved in obesity. WAT contains many adipocytes with energy storage capacity and secretes adipokines depending on the obesity state, while liver plays pivotal roles in glucose and lipid metabolism. This review outlines and underscores the relationship between obesity and lysosomal functions, including lysosome biogenesis, maturation and activity of lysosomal proteases in WAT and liver. It has been revealed that obesity-induced abnormalities of lysosomal proteases contribute to inflammation and cellular senescence in adipocytes. Previous reports have demonstrated obesity-induced ectopic lipid accumulation in liver is associated with abnormality of lysosomal proteases as well as other lysosomal enzymes. These studies demonstrate that lysosomal dysfunction in WAT and liver underlies part of the obesity-related pathology, raising the possibility that strategies to modulate lysosomal function may be effective in preventing or treating the metabolic syndrome.


Assuntos
Suscetibilidade a Doenças , Lisossomos/metabolismo , Síndrome Metabólica/etiologia , Síndrome Metabólica/metabolismo , Obesidade/etiologia , Obesidade/metabolismo , Tecido Adiposo/metabolismo , Animais , Humanos , Fígado/metabolismo , Síndrome Metabólica/prevenção & controle , Peptídeo Hidrolases/metabolismo
14.
Food Funct ; 10(6): 3660-3670, 2019 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-31166330

RESUMO

In this study, we investigated the effects of a newly synthesized α-galacto-oligosaccharide mixture (α-GOSg), 0.5% in drinking water, on high-fat/western-style diet (HFWD)-induced metabolic abnormality in mice in a study of 13 weeks. Raffinose family oligosaccharides (RFOs) were included as a comparison. Mice treated with α-GOSg had significantly lower body weight and body fat (p < 0.05), while RFOs were less effective. Both α-GOSg and RFOs significantly reduced serum levels of total cholesterol and low-density lipoprotein cholesterol, alanine aminotransferase and liver lipids. However, only α-GOSg significantly decreased the histopathological score for liver steatosis and downregulated hepatic fatty acid synthesis gene acetyl CoA carboxylase-α. α-GOSg also significantly reduced the content of bile acids in the small intestine and significantly increased the abundance of gut Bifidobacterium and decreased the abundance of Clostridium leptum. These actions are proposed to be key mechanisms contributing to the beneficial health effects of α-GOSg.


Assuntos
Síndrome Metabólica/prevenção & controle , Oligossacarídeos/administração & dosagem , Substâncias Protetoras/administração & dosagem , Acetil-CoA Carboxilase/genética , Acetil-CoA Carboxilase/metabolismo , Animais , Bactérias/classificação , Bactérias/genética , Bactérias/isolamento & purificação , LDL-Colesterol/metabolismo , Dieta Hiperlipídica/efeitos adversos , Dieta Ocidental/efeitos adversos , Microbioma Gastrointestinal/efeitos dos fármacos , Humanos , Fígado/efeitos dos fármacos , Fígado/metabolismo , Masculino , Síndrome Metabólica/etiologia , Síndrome Metabólica/metabolismo , Síndrome Metabólica/microbiologia , Camundongos , Camundongos Endogâmicos C57BL
15.
J Oleo Sci ; 68(6): 517-524, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31168041

RESUMO

Abdominal fat accumulation causes metabolic syndrome, which is a cluster of metabolic abnormalities such as dyslipidemia, glucose intolerance, insulin resistance or hyperinsulinemia, and hypertension, leading to the development of diabetes and cardiovascular disease. Diets are known to contribute to the development or prevention of metabolic syndrome. Several studies have reported that the quality of dietary proteins may be an important modulator of the risk of this syndrome. We investigated the effects of consuming egg white protein (EWP) or lactic-fermented egg white (LE), an easy-to-consume form of egg white, on the development of metabolic syndrome in animal models and humans. In comparison with casein, dietary EWP decreased lymphatic lipid transport in thoracic lymph duct-cannulated rats. In an in vitro experiment, EWP pepsin hydrolysate decreased the cholesterol micellar solubility and cholesterol transfer rate from micelles to oil phase, and increased water-holding capacity, settling volume in water, and relative viscosity compared with casein pepsin hydrolysate. The daily consumption of LE for 8 weeks reduced serum total cholesterol and LDL cholesterol levels in men with mild hypercholesterolemia. Furthermore, dietary EWP reduced the body fat mass of rats by increasing the body protein mass and accelerating hepatic ß-oxidation. The daily consumption of LE for 12 weeks reduced the visceral fat area and improved the ratio of the visceral to subcutaneous fat area. Taken together, these results indicated that dietary EWP and LE would be useful for preventing or alleviating metabolic syndrome.


Assuntos
Dieta , Proteínas Dietéticas do Ovo/administração & dosagem , Proteínas Dietéticas do Ovo/farmacologia , Síndrome Metabólica/prevenção & controle , Síndrome Metabólica/terapia , Tecido Adiposo/metabolismo , Animais , Colesterol/metabolismo , LDL-Colesterol/metabolismo , Modelos Animais de Doenças , Humanos , Hipercolesterolemia/metabolismo , Gordura Intra-Abdominal/metabolismo , Fígado/metabolismo , Linfa/metabolismo , Síndrome Metabólica/etiologia , Micelas , Oxirredução , Pepsina A/farmacologia , Proteínas/metabolismo , Ratos , Solubilidade , Gordura Subcutânea/metabolismo , Ducto Torácico/metabolismo
16.
Diabetes Metab Syndr ; 13(3): 1699-1704, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31235081

RESUMO

PURPOSES: Diet has an important role in the management of chronic diseases. This study aimed to investigate the association of adherence to the dietary approaches to stop hypertension (DASH) diet with metabolic syndrome (MetS) and its components. METHODS: This cross-sectional study was performed on 396 Iranian adults, aged ≥18 years. A 147-item food frequency questionnaire (FFQ) was used to assess dietary intakes of participants. Fasting blood sample was obtained to quantify glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III). RESULTS: Mean age of study participants was 38.22 ±â€¯9.58 years. A significant inverse association was observed between adherence to DASH diet and odds of MetS (OR: 0.28, 95% CI: 0.14, 0.54); such that after adjusting for energy intake, socioeconomic status and body mass index (BMI), participants in the highest tertile of DASH diet scores were 49% less likely to have MetS (OR: 0.28, 95% CI: 0.14-0.54). Furthermore, adherence to DASH diet was inversely associated with elevated blood pressure (OR: 0.12, 95% CI: 0.05-0.29), high serum triglyceride (OR: 0.53, 95% CI: 0.28-1.00) and low serum HDL-C (OR: 0.51, 95% CI: 0.25-1.01). However, this association was marginally significant for triglyceride and HDL-C. No significant association was found between adherence to DASH diet and abdominal obesity. CONCLUSION: We found that adherence to DASH was inversely associated with odds of MetS and some of its components including elevated blood pressure, low serum HDL-C and high serum triglyceride.


Assuntos
Abordagens Dietéticas para Conter a Hipertensão/métodos , Hipertensão/dietoterapia , Síndrome Metabólica/prevenção & controle , Adulto , Biomarcadores/análise , Estudos Transversais , Feminino , Seguimentos , Humanos , Incidência , Irã (Geográfico)/epidemiologia , Masculino , Síndrome Metabólica/epidemiologia , Avaliação Nutricional , Prognóstico
17.
Diabetes Metab Syndr ; 13(3): 1949-1955, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31235120

RESUMO

OBJECTIVE: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of mobile health (m-health) interventions on lipid profiles among patients with metabolic syndrome and related disorders. METHODS: Cochrane Library, EMBASE, PubMed, and Web of Science databases were searched to indentify the relevant randomized clinical trials published up April 30th, 2018. Two reviewers examined study eligibility, extracted data, and assessed risk of bias of included clinical trials, individually. Heterogeneity was measured using I-square (I2) statistic and Cochran's Q test. Data were pooled the standardized mean difference (SMD) effect size by the random-effect model. RESULTS: 18 trials of 1681 citations were identified to be appropriate for the current meta-analysis. Findings random-effects model indicated that m-health interventions significantly decreased total- (SMD -0.54; 95% CI, -1.05, -0.03) and LDL-cholesterol levels (SMD -0.66; 95% CI, -1.18, -0.15). M-health interventions had no significant effect on triglycerides (SMD -0.14; 95% CI, -0.56, 0.28) and HDL-cholesterol levels (SMD -0.35; 95% CI, -0.81, 0.11). CONCLUSION: Overall, the current meta-analysis demonstrated that m-health interventions resulted in an improvement in total- and LDL-cholesterol, but did not affect triglycerides and HDL-cholesterol levels.


Assuntos
Suplementos Nutricionais , Lipídeos/sangue , Síndrome Metabólica/prevenção & controle , Telemedicina/métodos , Humanos , Síndrome Metabólica/sangue , Ensaios Clínicos Controlados Aleatórios como Assunto
18.
Diabetes Metab Syndr ; 13(3): 2266-2271, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31235167

RESUMO

AIMS: Physical activities of daily living (ADL) constitutes one of diabetes management options. This study aimed to assess the extent that ADL and BMI are evaluated among diabetes patients in hospital practice. METHOD: This was a clinical observational baseline study in two hospitals. Audit of medical files was performed to assess if BMI and occupations were recorded (N = 112). Afterwards, 'N = 38' who consented to participate in prospective study were conveniently sampled to assess ADL in relation to accessible metabolic syndrome tests. A validated questionnaire was used to collect data, which were analysed using SPSS version 20. RESULTS: Audit shows 55/112 of clients' occupation were taken, of which 31% has BMI record. Those with lipid profile results are without blood pressure and vice versa. In the cross-sectional assessment, 74% are in physically demanding ADL occupations, but affirmed inactivity is 98% on leisure exercise. Further, 47% have BMI >25 kg/m2 and were consistently less active on all leisure ADL relative to those with BMI <25 kg/m2 (p < 0.02). CONCLUSION: This report highlights oversight in clinical practice, whereby accessible metabolic syndrome parameters and occupation of clients living with diabetes are being assessed inconsistently. This implies an unmet need in the integration BMI and occupational information to improve diabetes self-management.


Assuntos
Atividades Cotidianas , Índice de Massa Corporal , Diabetes Mellitus/prevenção & controle , Exercício , Instalações de Saúde/estatística & dados numéricos , Auditoria Médica/estatística & dados numéricos , Adolescente , Adulto , Idoso , Estudos Transversais , Gerenciamento Clínico , Feminino , Seguimentos , Humanos , Masculino , Síndrome Metabólica/prevenção & controle , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Inquéritos e Questionários , Atenção Terciária à Saúde , Adulto Jovem
19.
Food Funct ; 10(7): 4153-4165, 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31241065

RESUMO

This study aimed to explore a novel strategy for the simultaneous consumption of soluble soybean polysaccharides (SSPS) and insoluble genistein to improve the bioavailability of genistein and its prevention against obesity and metabolic syndrome in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were fed a normal diet and HFD supplemented or not (n = 8) with SSPS (2.5%), genistein (0.5%) and their mixture (S + G) for 12 weeks. The UPLC-qTOP/MS assay showed that SSPS observably enhanced the urinary concentration of genistein and its metabolites compared to that of single genistein in mice. Supplementation of SSPS, genistein or their combination prevented HFD-induced gain weight, dyslipidemia, oxidative stress and inflammation in obese mice. Interestingly, the combined S + G ingestion exhibited more effective alleviation of dyslipidemia by modulating hepatic FAS, ACC, SREBP-1C and ADRP expressions relative to that of individual SSPS or genistein. Furthermore, S + G activated the energy metabolism pathway AMPK in the liver, and the hepatic PPAR-α/PPAR-γ pathways were doubly activated to alleviate lipogenesis, inflammation, obesity and metabolic syndrome. Moreover, S + G supplementation dramatically modified the gut microbial species at the phylum level with a decrease in Firmicutes and increase in Bacteroidetes. These findings support that the combined supplementation of SSPS and genistein is a novel couple to prevent obesity and metabolic syndrome.


Assuntos
Disponibilidade Biológica , Genisteína/farmacologia , Síndrome Metabólica/prevenção & controle , Obesidade/prevenção & controle , Polissacarídeos/farmacologia , Soja/química , Animais , Bactérias/classificação , Bactérias/efeitos dos fármacos , Dieta Hiperlipídica/efeitos adversos , Suplementos Nutricionais , Dislipidemias/metabolismo , Fezes/microbiologia , Microbioma Gastrointestinal/efeitos dos fármacos , Genisteína/uso terapêutico , Inflamação , Fígado/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Obesos , Estresse Oxidativo , PPAR alfa/metabolismo , PPAR gama/metabolismo , Perilipina-2/metabolismo , Extratos Vegetais/farmacologia , Polissacarídeos/uso terapêutico , RNA Ribossômico 16S/genética , Proteína de Ligação a Elemento Regulador de Esterol 1/metabolismo , Ganho de Peso/efeitos dos fármacos , Receptor fas/metabolismo
20.
Nutrients ; 11(5)2019 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-31052301

RESUMO

: The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.


Assuntos
Dieta/estatística & dados numéricos , Síndrome Metabólica/epidemiologia , Nutrientes/administração & dosagem , Nutrientes/classificação , Adulto , Idoso , Cálcio na Dieta/administração & dosagem , Cálcio na Dieta/metabolismo , Estudos de Coortes , Estudos Transversais , Inquéritos sobre Dietas , Gorduras na Dieta/administração & dosagem , Gorduras na Dieta/metabolismo , Fibras na Dieta/administração & dosagem , Fibras na Dieta/metabolismo , Ingestão de Energia , Análise Fatorial , Feminino , Humanos , Japão/epidemiologia , Masculino , Síndrome Metabólica/prevenção & controle , Pessoa de Meia-Idade , Estado Nutricional , Prevalência , Vitaminas/administração & dosagem , Vitaminas/metabolismo
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