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1.
Medicine (Baltimore) ; 98(51): e18450, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31861018

RESUMO

Restless legs syndrome (RLS) increases the risks of cardiovascular disease and death in hemodialysis (HD) patients. Previous studies of risk factors for RLS in HD patients have yielded varying results. We attempted to identify risk factors for RLS in HD patients in Taiwan.This case-control study recruited 59 HD patients with RLS and 353 HD patients without RLS from the largest HD center in Taiwan during the period from April 1, 2015 through August 31, 2015. Demographic and disease characteristics, information from the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic questionnaire, and IRLSSG Severity Scale scores were collected by interview. Clinical laboratory data were abstracted from medical records and then analyzed with logistic regression and Pearson correlation analysis. A P value of less than .05 was considered to indicate statistical significance.A dialysis duration of longer than 5 years (odds ratio [OR] = 2.32; 95% CI = 1.23-4.39; P = .002) and a low high-density lipoprotein cholesterol level (<40 mg/dL in men; <50 mg/dL in women) (OR = 2.73; 95% CI = 1.44-5.15; P = .009) were associated with increased risk of RLS. Among the 59 patients with RLS, 48 (81.3%) had moderate or severe symptoms (IRLSSG Severity Scale >10), and RLS severity was significantly correlated with dialysis duration (r = .26; P = .043).Among HD patients, RLS was more common among those receiving dialysis for longer than 5 years and those with a low serum high-density lipoprotein cholesterol (HDL-C) level.


Assuntos
Falência Renal Crônica/complicações , Síndrome das Pernas Inquietas/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Feminino , Humanos , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Diálise Renal , Síndrome das Pernas Inquietas/etiologia , Fatores de Risco , Taiwan/epidemiologia , Adulto Jovem
2.
Ideggyogy Sz ; 72(7-8): 236-240, 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31517455

RESUMO

Introduction - Restless Leg Syndrome (RLS) is a disease, primarily composed of sensational symptoms, caused by the urge to move lower extremities especially at night, and characterized by undesired feelings of the legs. Decreasing of the dopaminergic effect at night is thought to be responsible from these symptoms. RLS patients suffer from low quality of sleep affecting their daily life activities even causing socio-economic loss. Although RLS is a common and treatable disease, it can not be diagnosed easily due to the variability of symptoms. Aim - The purpose of this study is to determine the frequency of RLS among health workers and to define the disease causing factors. Method - A questionnaire was applied to 174 randomly selected health workers at Baskent University Medical Faculty (KA17/285). The demographic information, history of illnesses or usage of drugs, socioeconomic status, working hours and daytime sleepiness were questioned. Included in the questionnaire were diagnostic criteria for RLS, frequency assessment scale, and survey of sleep quality. We used "the diagnostic criteria of international RLS working group" for the diagnosis, and "Pittsburgh sleep quality index survey" to determine the quality of sleep. Reliability and validity studies were performed on both tests. Results - A significant relationship between socio-economic status and RLS was found (p<0.05) as an increase of RLS frequency in parallel with decreased socio-economic status. RLS was found to be common among health workers. We suggest that health workers should be checked regularly, and they should be informed about the disease in order to raise an awareness and hence increase their quality of life.


Assuntos
Qualidade de Vida/psicologia , Síndrome das Pernas Inquietas/psicologia , Transtornos do Sono-Vigília/fisiopatologia , Humanos , Reprodutibilidade dos Testes , Síndrome das Pernas Inquietas/epidemiologia , Sono/fisiologia , Inquéritos e Questionários
3.
Postgrad Med ; 131(7): 473-478, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31522582

RESUMO

Objectives: Non-motor symptoms (NMS) range from neuropsychiatric to pain and are an important but underexplored feature of restless legs syndrome (RLS). There are currently no tools available which enable the holistic assessment of NMS in RLS in clinical practice. The primary aim of this study was to systematically assess NMS prevalence and burden in patients with RLS using the NMS Questionnaire (NMSQuest) validated for Parkinson's disease. Methods: Patients with idiopathic RLS according to the criteria of the international RLS study group (IRLSSG) were included. Patients underwent a physical examination and clinical interview as well as completed the NMS Questionnaire and the international restless legs syndrome study group (IRLSSG) rating scale. Results: Seventy-four patients with primary RLS were included (mean age 64.6 ± 14.4 years, 62.2% female, mean disease duration 23.5 ± 17.8 years, mean Levodopa equivalent daily dose 63.3 ± 67.4 mg). On average patients reported an IRLSSG rating scale score of 24.8 ± 8.2 (maximum 40) and NMSQuest score of 9.9 ± 5.0 (maximum 30). Patients reported a minimum of two NMS with the majority (39.2%) reporting a moderate NMS burden, followed by severe (28.4%) and very severe (17.6%) burden. The most frequent NMS were insomnia (89.2%) followed by nocturia (70.3%), feeling sad (59.5%), forgetfulness (54.1%), urgency (47.3%), feeling anxious (43.2%), unexplained pain (41.9%), difficulty concentrating (40.5%) and dizziness (40.5%). There were no significant differences in NMSQuest total scores according to disease duration and gender (p = 0.739, p = 0.849). Conclusion: In conclusion, this study is one of the first to address NMS in RLS systematically and the data underlines the need to holistically assess NMS in RLS in order to deliver true value-based healthcare for these patients.


Assuntos
Ansiedade/epidemiologia , Tontura/epidemiologia , Transtornos da Memória/epidemiologia , Noctúria/epidemiologia , Dor/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Idoso , Estudos de Coortes , Efeitos Psicossociais da Doença , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome das Pernas Inquietas/fisiopatologia , Tristeza , Índice de Gravidade de Doença , Inquéritos e Questionários
4.
Int Heart J ; 60(5): 1098-1105, 2019 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-31484875

RESUMO

The restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs or arms for relief of uncomfortable or unpleasant sensations. Prevalence and prognostic impact of RLS on patients with heart failure (HF) remain unclear. We aimed to investigate the clinical characteristics and prognostic impact of RLS on HF patients.Consecutive 338 HF patients were evaluated for RLS and divided into two groups on the basis of presence of RLS: HF patients with RLS (RLS group, n = 29) and HF patients without RLS (non-RLS group, n = 309). We compared clinical characteristics, parameters of laboratory data and echocardiography, and rate of follow-up cardiac events including worsening HF and cardiac death between the two groups. Compared with the non-RLS group, the RLS group had higher prevalence of anemia (65.5% versus 40.8%, P = 0.010), higher usage of inotropic agents (31.0% versus 15.2%, P = 0.028), higher levels of B-type natriuretic peptide (570.8 versus 215.8 pg/mL, P = 0.018), and lower levels of left ventricular ejection fraction (40.4% versus 48.4%, P = 0.019). By contrast, age, gender, prevalence of other co-morbidities and medications were comparable between the groups. In the Kaplan-Meier analysis, the cardiac event rate was significantly higher in the RLS group than in the non-RLS group (log-rank P = 0.034). In the Cox proportional hazard analysis, RLS was a predictor for cardiac events in HF patients (hazard ratio: 1.783, 95% confidence interval: 1.038-3.063).RLS is associated with adverse prognosis in HF patients.


Assuntos
Causas de Morte , Progressão da Doença , Insuficiência Cardíaca/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Estudos de Coortes , Comorbidade , Feminino , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/terapia , Hospitais Universitários , Humanos , Japão , Estimativa de Kaplan-Meier , Modelos Logísticos , Masculino , Análise Multivariada , Prevalência , Prognóstico , Modelos de Riscos Proporcionais , Estudos Prospectivos , Síndrome das Pernas Inquietas/diagnóstico , Síndrome das Pernas Inquietas/terapia , Medição de Risco , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Análise de Sobrevida
5.
J Clin Neurosci ; 69: 139-142, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31439483

RESUMO

BACKGROUND: The determinants of restless legs syndrome (RLS) occurring in co-morbid association with Parkinson's disease (PD) are currently unknown. METHODS: We performed a skin biopsy in proximal and distal sites of lower limbs in four PD patients, in which RLS had emerged in the pre-motor phase. RESULTS: A reduced somato-sensory intraepidermal nerve fiber (IENF) density mainly in the proximal sites, indicative of non-length-dependent small fiber pathology (SFP), was found in all patients, in absence of electroneurographic signs of large fiber neuropathy. DISCUSSION: The lack of known secondary causes of SFP is consistent with a process intrinsic to PD and, likewise, the absence of known disease conditions associated to RLS, would support the view of a link between the latter disorder and the distal axonopathy. The non-length-dependent pattern of SFP suggest an involvement of the somato-sensory dorsal root ganglia small neurons, consistent with a somato-sensory neuronopathy, which characterizes the RLS in these patients. CONCLUSION: If these findings will be confirmed in a larger cohort of patients, the RLS co-morbid with PD should be regarded as an heterogeneous condition, since the one emerging in the pre-motor phase might represent a prodromal feature of the neurodegenerative disease as an epiphenomenon of somato-sensory SFP. In contrast, for the RLS developing in clinically manifest PD, a possible association with the impairment of the DAergic diencephalo-spinal pathway and the induction by chronic DAergic treatment has been hypothesized.


Assuntos
Doença de Parkinson/complicações , Síndrome das Pernas Inquietas/complicações , Comorbidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sintomas Prodrômicos , Síndrome das Pernas Inquietas/epidemiologia
6.
Neurol India ; 67(3): 732-737, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31347545

RESUMO

Context: Restless leg syndrome (RLS) has been reported to be common in patients with cirrhosis. The relation of RLS with severity of liver disease is, however, unclear. Aim: We studied the association between occurrence of RLS and severity of cirrhosis. Setting and Design: Single centre, prospective, observational study. Materials and Methods: Adult patients with cirrhosis and relatively stable clinical condition and no associated neurological condition were prospectively studied. Severity of liver disease was graded as Child-Turcotte-Pugh (CTP) class A, B or C; using Model for End-Stage Liver Disease (MELD) score; and as a binary variable (compensated or decompensated disease). Each subject underwent an initial screening for RLS, followed by a re-evaluation by an independent neurologist to confirm the diagnosis, using the International RLS Diagnostic Criteria. In patients with RLS, its severity was assessed using a validated Hindi translation of the International RLS severity (IRLS) scoring system. Statistical Analysis Used: Data for categorical variables were expressed as proportions and compared using chi-squared test, and those for numerical variables were expressed as median and range, and compared using Wilcoxon rank sum test. Results: Among the 356 patients with cirrhosis studied (median [range] age: 48 [18-83] years; 241 [67.7%] male; CTP A/163, B/172, C/21; MELD 11 [6-41]; decompensated 51.7%), 36 (10.1%) had RLS. RLS severity was mild (1), moderate (15), severe (19) or very severe (1). Compared to those without RLS, patient with RLS had a lower MELD score (9 [6-25] versus 11 [6-41], P = 0.04), and a comparable distribution of CTP classes and frequency of decompensated liver disease. The prevalence and severity of RLS were not different between those with compensated and those with decompensated cirrhosis. Conclusion: In the Indian population, RLS is common in patients with cirrhosis. Its occurrence did not show any increase with the severity of liver disease.


Assuntos
Cirrose Hepática/epidemiologia , Hepatopatias/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Cirrose Hepática/complicações , Hepatopatias/complicações , Pessoa de Meia-Idade , Estudos Prospectivos , Síndrome das Pernas Inquietas/complicações , Índice de Gravidade de Doença , Adulto Jovem
7.
Rev Assoc Med Bras (1992) ; 65(5): 618-624, 2019 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-31166437

RESUMO

OBJECTIVE: In this study, we aimed to determine the extent of restless legs syndrome (RLS) in pregnant women and evaluate the relationship between the syndrome and quality of life. METHODS: This is a cross-sectional descriptive study. A questionnaire developed by the researcher, the Short Form 36 (SF-36) Questionnaire to measure the quality of life, the International Restless Legs Syndrome Study Group (IRLSSG) Diagnostic Criteria for RLS and the Restless Legs Syndrome Rating Scale were applied to the women to collect the data. A total of 250 pregnant women were included in the study. RESULTS: The mean age of the women was 28.11 ± 5.59 years and the mean gestational time was 26.26 ± 10.72 weeks. Symptoms of RLS were seen in 46.4 % of the women. The mean for the RLS Violence Rating Score was 20.82 ± 6.61 for the women with RLS. RLS was found to be mild in 5.2 % of the women, moderate in 45.7 %, severe in 40.5 % and very severe in 8.6 %. A statistically significant effect of RLS survival on quality of life was observed. CONCLUSION: These results indicate that almost half of the pregnant women in this study experienced RLS, and about half of those with RLS experienced severe or very severe RLS. There is a significant relationship between RLS and six domains of SF-36 (physical, role limitations, pain, general health perception, energy/vitality, and mental health).


Assuntos
Complicações na Gravidez/epidemiologia , Complicações na Gravidez/fisiopatologia , Qualidade de Vida , Síndrome das Pernas Inquietas/epidemiologia , Síndrome das Pernas Inquietas/fisiopatologia , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Gravidez , Prevalência , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Inquéritos e Questionários , Turquia/epidemiologia , Adulto Jovem
8.
Int J Neurosci ; 129(10): 995-1003, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31092087

RESUMO

Objective: Restless legs syndrome (RLS) is one of the most common non-motor symptoms of Parkinson's disease (PD), but its pathogenesis in a PD background is unclear. Abnormal iron metabolism may be involved, in which case it may be a marker of RLS risk. Here, the literature was systematically searched and meta-analyzed to compare iron metabolism markers between PD patients with or without RLS. Method: The databases PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, Web of Science, and SinoMed were searched for case-control and observational studies examining RLS-related changes in iron metabolism in PD, in terms of serum iron, serum ferritin and hemoglobin. Eligible studies were meta-analyzed using Stata 12.0. Results: Meta-analysis of 11 case-control studies showed that serum ferritin concentration was lower in PD patients with RLS than in those without RLS. (95%CI -0.32 to -0.03, p = 0.018). In contrast, levels of serum iron or hemoglobin did not differ significantly between PD patients with or without RLS. Conclusion: This meta-analysis may provide the first reliable pooled estimate of the correlation between abnormal iron metabolism and RLS in PD. The available evidence indicates that levels of ferritin, but not of serum iron or hemoglobin, correlate significantly with RLS in PD, with lower ferritin levels correlating to greater prevalence of RLS.


Assuntos
Ferritinas/sangue , Doença de Parkinson/sangue , Doença de Parkinson/diagnóstico , Síndrome das Pernas Inquietas/sangue , Síndrome das Pernas Inquietas/diagnóstico , Biomarcadores/sangue , Estudos de Casos e Controles , Humanos , Doença de Parkinson/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia
9.
Neurology ; 92(20): 948-964, 2019 05 14.
Artigo em Inglês | MEDLINE | ID: mdl-31004074

RESUMO

OBJECTIVE: This review focuses on the possible association between restless legs syndrome (RLS) and movement disorders, including Parkinson disease (PD), other parkinsonian syndromes, essential tremor, choreic and dystonic syndromes, Tourette syndrome, and heredodegenerative ataxias. METHODS: Review of PubMed from 1966 to September 2018 and identification of references of interest for the topic. A meta-analysis of eligible studies on the frequency of RLS in patients with PD and controls using Meta-DiSc1.1.1 software and using the PRISMA guidelines was performed. RESULTS AND CONCLUSIONS: Although there are substantial clinical, neuroimaging, neuropathologic, and genetic differences between RLS and PD, many reports describe a higher than expected prevalence of RLS in patients with PD, when compared with the general population or with matched control groups; several studies have also suggested that RLS could be an early clinical feature of PD. RLS symptoms are frequent in multiple system atrophy, essential tremor, Tourette syndrome, Friedreich ataxia, and spinocerebellar ataxia type 3 as well. Finally, possible genetic links between PD and RLS (the presence of allele 2 of the complex microsatellite repeat Rep1 within the α-synuclein gene promoter) and between Tourette syndrome and RLS (several variants in the BTBD9 gene) have been reported in 2 case-control association studies, although these data, based on preliminary data with small sample sizes, need to be replicated in further studies.


Assuntos
Coreia/epidemiologia , Distonia/epidemiologia , Doença de Parkinson/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Degenerações Espinocerebelares/epidemiologia , Síndrome de Tourette/epidemiologia , Tremor Essencial/epidemiologia , Tremor Essencial/genética , Ataxia de Friedreich/epidemiologia , Humanos , Doença de Machado-Joseph/epidemiologia , Transtornos dos Movimentos/epidemiologia , Atrofia de Múltiplos Sistemas/epidemiologia , Doença de Parkinson/genética , Transtornos Parkinsonianos/epidemiologia , Síndrome das Pernas Inquietas/genética , Síndrome de Tourette/genética
10.
BMC Neurol ; 19(1): 47, 2019 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-30925907

RESUMO

BACKGROUND: The prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. However, the associations of RLS within the ESRD population are inconsistent and RLS is usually neglected in dialysis centers, although it impairs the life quality among ESRD patients. We aim to investigate the prevalence of RLS in patients with ESRD undergoing maintenance hemodialysis and evaluate the risk factors of developing RLS and the effect of RLS on quality of life among ESRD patients. METHODS: ESRD patients undergoing maintenance hemodialysis in Shanghai General Hospital dialysis unit from July 2016 to October 2016 were enrolled in the study. RLS was diagnosed according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG). IRLSSG Severity Scale was used to evaluate the severity of RLS. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and Hospital Anxiety and Depression Scale (HADS) was used to estimate anxiety and depression. Serologic and historic variables were analyzed to determine predictors of RLS in the ESRD population. RESULTS: A total of 137 ESRD patients were enrolled. The prevalence of RLS among the ESRD patients was 20.44%. The risk of RLS was increased significantly in females (OR = 2.729, p = 0.032) and daily alcohol drinkers (OR = 4.716, p = 0.022). RLS increased the risks of sleep disorders (25/28, 89.3% vs 73/109, 67.0%, p = 0.02) and sedative hypnotics intake (7/28, 25.0% vs 10/109, 9.2%, p = 0.047) and impaired the sleep quality (7/109 vs 11/28, p = 0.001) according to PSQI sum scores. CONCLUSION: A high RLS prevalence among the ESRD patients undergoing hemodialysis was confirmed. ESRD patients who are women and drinking alcohol have a higher risk of RLS. The sleep quality was significantly impaired and sleeping medication use was more common among the ESRD patients with RLS.


Assuntos
Falência Renal Crônica/terapia , Diálise Renal , Síndrome das Pernas Inquietas/epidemiologia , Adulto , Idoso , Ansiedade/epidemiologia , China , Depressão/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Qualidade de Vida , Fatores de Risco , Sono , Transtornos do Sono-Vigília/epidemiologia
11.
J Coll Physicians Surg Pak ; 29(4): 309-312, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30925950

RESUMO

OBJECTIVE: To investigate whether restless leg syndrome (RLS) symptoms improved and treatment requirement decreased through weight loss on postoperative follow-ups of the patients who underwent laparoscopic sleave gastrectomy (LSG) due to obesity and who were started medical therapy due to RLS. STUDY DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: General Surgery Outpatient Clinics of Research and Training Hospital of Medical School, Adiyaman, Turkey, from May 2014 to December 2017. METHODOLOGY: A total of 14 patients who underwent LSG due to morbid obesity and who received medical treatment due to RLS were retrospectively included in the study. The improvement of the symptoms and no need for medical treatment were considered as treatment or recovery criterion. Those who were not diagnosed with RLS before the operation or who did not receive medical treatment due to RLS were excluded. RESULTS: The study subjects comprised 6 females (42.9%) and 8 males (57.1%). Mean BMI was 46.50 ±3.43 Kg/m² before LSG and 28.28 ±2.26 Kg/m² on months 12 after LSG. Mean BMI values 12 months after LSG were significantly reduced compared to preoperative BMI (p=0.001). Out of the 14 patients who had been receiving medical therapy before LSG, 12 patients (85.7%) had discontinued medical therapy 12 months after LSG. A statistically significant difference was detected between the number of the patients who were receiving medical therapy due to RLS on month 12 after LSG and the number of the patients who were receiving medical therapy before LSG (p=0.001). CONCLUSION: Treatment requirements of morbid obese patients who were receiving medical therapy due to RLS significantly decreased through weight loss following RLS.


Assuntos
Cirurgia Bariátrica/métodos , Gastrectomia/métodos , Laparoscopia/métodos , Obesidade Mórbida/cirurgia , Perda de Peso , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/diagnóstico , Obesidade Mórbida/epidemiologia , Complicações Pós-Operatórias , Síndrome das Pernas Inquietas/complicações , Síndrome das Pernas Inquietas/epidemiologia , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Resultado do Tratamento
12.
Am J Cardiol ; 123(10): 1580-1586, 2019 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-30850211

RESUMO

Restless legs syndrome (RLS), characterized by leg restlessness and dysesthesia predominantly at night and at rest, disrupts sleep and quality of life. The reported prevalence of RLS is 2% to 5%. Although a relation between RLS and coronary artery disease has been suggested, the prevalence and clinical significance of RLS in coronary artery disease patients remain unknown. We enrolled coronary artery disease patients who underwent percutaneous coronary intervention. Patients with RLS were identified according to international criteria. Subjective sleepiness, sleep quality, and health-related quality of life were assessed using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Short Form-8, respectively. Among 326 patients with coronary artery disease, 26 (8.0%) had RLS. There were no significant differences in characteristics between patients with and without RLS. Sleep quality and quality of life were more disrupted in patients with RLS (Pittsburgh Sleep Quality Index score, 7.4 ± 2.4 vs 5.6 ± 2.5, p <0.001; physical component summary and mental component summary scores of Short Form-8, 39.6 ± 1.8 vs 43.5 ± 0.5, p = 0.042 and 45.2 ± 8.4 vs 48.4 ± 7.4, p = 0.037, respectively), despite no significant difference in Epworth Sleepiness Scale score (8.2 ± 5.1 vs 7.1 ± 4.8, p = 0.293). In multiple linear regression analyses, RLS was independently associated with Pittsburgh Sleep Quality Index (ß = 0.174, p <0.001), physical component summary (ß = -0.127, p = 0.029), and mental component summary (ß = -0.113, p = 0.042) scores. In conclusion, in patients with coronary artery disease, the prevalence of RLS was relatively high compared to that reported in the general population. The presence of RLS was associated with disrupted sleep quality and health-related quality of life in coronary artery disease patients.


Assuntos
Doença da Artéria Coronariana/complicações , Qualidade de Vida , Síndrome das Pernas Inquietas/epidemiologia , Sono/fisiologia , Idoso , Feminino , Humanos , Japão/epidemiologia , Masculino , Prevalência , Estudos Prospectivos , Síndrome das Pernas Inquietas/diagnóstico , Síndrome das Pernas Inquietas/etiologia , Índice de Gravidade de Doença , Inquéritos e Questionários
13.
Neuroepidemiology ; 52(3-4): 193-204, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30763945

RESUMO

BACKGROUND: Restless legs syndrome (RLS) is a common sleep disorder, although it has a low prevalence in Asian populations. However, the reported RLS prevalence in -Korean adults is mostly 4.5-12.1%, which is higher than that reported in other Asian populations. This study aimed to diagnose RLS and exclude mimicking conditions in 2 independent samples of Korean adults, and to compare its prevalence to that from previous studies performed in Asian countries. METHODS: Study populations included a (1) nationwide stratified random sample (n = 2,824; age 19-79 years) and (2) community-based cohort (n = 2,685; age 47-79 years). We applied the Cambridge-Hopkins diagnostic questionnaire to diagnose RLS and differentiate it from RLS mimics. Sleep-related symptoms, mood, and medical conditions were compared between the RLS and non-RLS groups. Prior studies of the RLS prevalence in Asia were systematically reviewed and compared to our findings. RESULTS: The adjusted RLS prevalence was 0.4 and 1.3% in populations 1 and 2, respectively. In both populations, subjects with RLS had more depression. The prevalence of RLS mimics was 5.1 and 2.6%, in populations 1 and 2, respectively. The RLS prevalence in Asia was higher when RLS was defined by the presence of essential clinical features and lower when a differential diagnosis was additionally implemented. CONCLUSIONS: The RLS prevalence in Korean adults considering RLS mimics is comparable to that in adults from other Asian countries (< 2%). The reported RLS prevalence varies depending on the diagnostic method employed.


Assuntos
Vigilância da População , Síndrome das Pernas Inquietas/diagnóstico , Síndrome das Pernas Inquietas/epidemiologia , Adulto , Idoso , Estudos de Coortes , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Vigilância da População/métodos , Prevalência , Estudos Prospectivos , República da Coreia/epidemiologia , Adulto Jovem
14.
BMJ Open ; 9(1): e024236, 2019 01 21.
Artigo em Inglês | MEDLINE | ID: mdl-30670516

RESUMO

OBJECTIVES: The prevalence of restless legs syndrome (RLS) in functional movement disorders (FMD) is not known. Patients with FMD often present with multiple motor and sensory symptoms. Some of these symptoms might be due to comorbid RLS. Therefore, our objective was to evaluate possible association between FMD and RLS. DESIGN: Case-control study. SETTING: Movement Disorders Center, 1st Faculty of Medicine and General University Hospital in Prague, Czech Republic. PARTICIPANTS: 96 consecutive patients with clinically established FMD (80 females, mean age (SD) 45.0 (13) years), and 76 matched controls. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was prevalence of RLS based on updated International RLS Study Group criteria. Secondary outcome measures included prevalence of periodic limb movements (PLM) using actigraphy; pain, motor and sensory symptoms in lower limbs; organic comorbidities and medication affecting RLS. RESULTS: RLS criteria were fulfilled in 43.8% of patients (95% CI 34 to 54) and in 7.9% of controls (95% CI 3 to 17, p<0.00001). Both RLS and PLM indices (PLMi) ≥22.5/hour were found in 21.2% of patients with FMD and 2.6% of controls. Patients with FMD with RLS had a higher mean PLMi (p<0.001) and a higher proportion of PLMi ≥22.5/hour (p<0.01) than RLS-negative patients. Patients with RLS had higher prevalence of pain and sensory symptoms in lower limbs, no difference was found in medication and prevalence of organic comorbidities in patients with FMD with and without RLS. CONCLUSIONS: We found an increased prevalence of RLS in patients with FMD. Clinical diagnosis of RLS was supported by actigraphic measurement of clinically relevant PLM in a significant proportion of patients with FMD. Although functional motor and sensory symptoms may mimic RLS, RLS may be unrecognised in patients with FMD. This finding may have clinical implications in management of FMD, and it raises the possibility of common pathophysiological mechanisms of FMD and RLS/PLM.


Assuntos
Transtorno Conversivo/epidemiologia , Transtornos dos Movimentos/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Adulto , Estudos de Casos e Controles , Transtorno Conversivo/fisiopatologia , República Tcheca/epidemiologia , Distonia/fisiopatologia , Feminino , Transtornos Neurológicos da Marcha/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos dos Movimentos/fisiopatologia , Debilidade Muscular/fisiopatologia , Mioclonia/fisiopatologia , Transtornos da Motilidade Ocular/fisiopatologia , Prevalência , Distúrbios da Fala/fisiopatologia , Tremor/fisiopatologia
15.
Med Pr ; 70(1): 9-16, 2019 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-30653198

RESUMO

BACKGROUND: The link between restless legs syndrome (RLS) and the number of amalgam fillings in older people was investigated. Restless legs syndrome decreases the quality of life and impairs normal functioning. Mercury (in amalgam) may be toxic to nerve cells and may account for the incidence of RLS. MATERIAL AND METHODS: The relationship between RLS and the presence of amalgam in the teeth of 104 people aged 60-97 years old was determined. By using 4 questions, together with the diagnostic criteria from the internationally used questionnaire produced by the International Restless Legs Syndrome Study Group (IRLSSG), authors assessed the extent of the symptoms and occurrence of RLS. Careful medical history and medical examination were used for ascertaining each subject's type of restorative materials (i.e., amalgam or other metal) and the number of such fillings. RESULTS: Subjects who answered "yes" (indicating presence of RLS) to the 4 subsequent questions had a significantly higher number of amalgam dental fillings as compared to the subjects without RLS symptoms. Presence of other metal dental restorative materials and the number of amalgam dental fillings reported in the past had no significant influence on RLS symptomatology. CONCLUSIONS: Authors conclude that while examining the correlates of the appearance of restless legs syndrome the use of amalgam in the dentition should be taken into account. Med Pr. 2019;70(1):9-16.


Assuntos
Amálgama Dentário/efeitos adversos , Síndrome das Pernas Inquietas/epidemiologia , Síndrome das Pernas Inquietas/etiologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Mercúrio/efeitos adversos , Mercúrio/toxicidade , Pessoa de Meia-Idade , Prevalência , Síndrome das Pernas Inquietas/induzido quimicamente , Inquéritos e Questionários
16.
J Obstet Gynaecol ; 39(4): 480-484, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30620232

RESUMO

The objective of the present study was to investigate the frequency and the risk factors for restless legs syndrome (RLS) during pregnancy in an Italian population rarely studied, in epidemiological studies on the syndrome. A total of 648 women (median age: 35 years; interquartile range: 32-38), who delivered on randomly selected days at the obstetric department of our hospital, were identified. One hundred and thirty-two women (20.4%, 95% confidence interval (CI): 17.3-23.5) met the criteria for a diagnosis of RLS. The odds ratio (OR) of RLS was, in comparison with women aged <35 years, 1.69 (95% CI 1.14-2.51) in women aged ≥35 years. Subjective insufficient sleep (OR: 2.35, 95% CI 1.27-4.35) and difficulty in initiating sleep (OR: 1.73, 95% CI 1.15-2.63) increased the risk of RLS. This study confirms the high frequency of RLS in pregnant women. The risk of the condition was increased in women aged ≥35 years and in the women reporting sleep-wake disturbances during pregnancy. Impact statement What is already known on this subject? Restless legs syndrome (RLS), a common neurological, sensorimotor disorder, is two/three times more frequent in pregnant women than in the general population. The prevalence of RLS during pregnancy ranges widely, showing differences among populations. What do the results of this study add? This study adds data about the frequency and the risk factors for RLS during pregnancy in a Northern Italian population, rarely considered in epidemiological studies on the syndrome. Older age and sleep-wake disturbances are the main factors associated with the condition. What are the implications of these findings for clinical practice and/or further research? Screening for RLS might be useful for pregnant women to manage the condition. Further research is needed to investigate and define the potential impact of RLS during pregnancy on foetal and maternal health.


Assuntos
Complicações na Gravidez/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Adulto , Feminino , Humanos , Itália/epidemiologia , Razão de Chances , Gravidez , Complicações na Gravidez/etiologia , Prevalência , Síndrome das Pernas Inquietas/etiologia , Fatores de Risco , Transtornos do Sono-Vigília/complicações , Adulto Jovem
17.
Psychiatry Res ; 273: 37-41, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30639562

RESUMO

Depression causes sleep disturbance and is associated with various sleep-related disorders. However, how depression affects the symptomatic presentation of different sleep-related disorders is unclear. In this study, we investigated the sleep parameters of different sleep-related disorders between depressive and non-depressive patients. A total of 785 patients underwent polysomnography in a mental hospital from Jan 2012 to Jun 2013. We first analyzed variables between the depressive and non-depressive groups. The patients were then divided into four groups: obstructive sleep apnea (OSA, n = 339), restless leg syndrome (RLS, n = 51), periodic limb movement disorder (PLMD, n = 58) and comorbid group (OSA and RLS, n = 46). We next compared sleep measures between the depressive and non-depressive subjects within each groups. The patients with OSA and depression were significantly associated with a higher periodic limb movement index. Significantly more patients with RLS patients and depression had initial insomnia complaints. However, significantly more patients with PLMD and depression middle insomnia. Compared with non-depressive population, depressive patients had higher comorbidity with RLS and PLMD. Depression may have different association with the sleep parameters in different sleep-related disorders. Further investigations are needed to investigate how these findings may affect patients' awareness and clinicians' diagnosis and management of sleep-related disorders.


Assuntos
Depressão/epidemiologia , Síndrome da Mioclonia Noturna/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Apneia Obstrutiva do Sono/epidemiologia , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Adulto , Comorbidade , Depressão/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome da Mioclonia Noturna/psicologia , Polissonografia/métodos , Síndrome das Pernas Inquietas/psicologia , Estudos Retrospectivos , Apneia Obstrutiva do Sono/psicologia , Distúrbios do Início e da Manutenção do Sono/psicologia
18.
Eur J Neurol ; 26(2): 238-245, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30169898

RESUMO

BACKGROUND AND PURPOSE: No prospective study has evaluated the impact of restless legs syndrome (RLS) on clinical factors in patients with migraine. We planned a prospective study to assess the impact of RLS comorbid status on clinical factors in patients with migraine. METHODS: A total of 101 patients with migraine who were evaluated for RLS twice at 7-year intervals in a university hospital setting were included in this study. The RLS group was defined as positive for RLS at either baseline or follow-up and the non-RLS group was defined as negative for RLS at both baseline and follow-up. The Migraine Disability Assessment (MIDAS) questionnaire, Beck Depression Inventory-II (BDI-II), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale were administered to all patients. RESULTS: The RLS prevalence was 16.8% at baseline and 20.8% at follow-up. Compared with the non-RLS group (n = 27), the RLS group (n = 74) showed a significantly higher rate of smoking and higher MIDAS and BDI-II scores at 7-year follow-up. A significant reduction in MIDAS and BDI-II scores at 7-year follow-up compared with those at baseline was observed in the non-RLS group, but not in the RLS group. The non-RLS group showed a significantly lower MIDAS score at 7-year follow-up than the RLS group after adjusting for confounding variables such as age, gender, smoking status, Epworth Sleepiness Scale and PSQI scores using analysis of covariance. The persistent RLS group (n = 11) (positive for RLS at both baseline and follow-up) showed a significantly higher rate of smoking and increased MIDAS, BDI-II and PSQI scores compared with the non-RLS group (n = 74) at 7-year follow-up. CONCLUSION: Our prospective study showed that RLS had a significant impact on headache-related disability in patients with migraine.


Assuntos
Cefaleia/epidemiologia , Transtornos de Enxaqueca/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia , Adulto , Comorbidade , Avaliação da Deficiência , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Inquéritos e Questionários
19.
Neurol Sci ; 40(1): 227-228, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30280360

RESUMO

The recent manuscript by Xinglong Yang and colleagues provided the first relatively reliable estimate of restless leg syndrome (RLS) prevalence among migraine sufferers, which was estimated at 19% (95% CI 14-24%). The implications of the association between the two conditions are wide, and call for further action aimed to address common disease mechanism-associated conditions such as sleep-related ones and associated burden.


Assuntos
Transtornos de Enxaqueca/diagnóstico , Transtornos de Enxaqueca/fisiopatologia , Síndrome das Pernas Inquietas/diagnóstico , Síndrome das Pernas Inquietas/fisiopatologia , Humanos , Transtornos de Enxaqueca/epidemiologia , Síndrome das Pernas Inquietas/epidemiologia
20.
J Sports Sci ; 37(8): 950-957, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30372656

RESUMO

The aim of this study was to determine the prevalence of sleep disorders in an elite rugby union team using in-laboratory polysomnography (PSG) and sleep questionnaires. Twenty-five elite rugby union players underwent a night of PSG during the "off-season" of the Super Rugby competition to assess their sleep. Of interest were measurements that detected the presence of obstructive sleep apnea (OSA; apnea-hypopnea index ≥5 events/hr) and the presence of moderate-severe periodic leg movements during sleep (PLMs; ≥15 events/hr). Players completed sleep-related questionnaires to assess daytime sleepiness, perception of insomnia, risk of OSA, and the presence of restless legs syndrome (RLS) and underwent basic anthropometric assessments including body mass index and neck circumference. OSA was present in 24% (n=6) of players and PLMs ≥15 events/hr in 12% (n=3). Questionnaire responses showed that all players had insomnia defined subthreshold insomnia and excessive daytime sleepiness, two players were identified as being at risk for OSA and none were classified as having RLS. In conclusion, sleep disorders and excessive sleepiness are common in elite rugby union players. A process to identify and manage sleep disorders should be considered by teams to optimise their physical recovery, athletic performance and to safeguard their health.


Assuntos
Futebol Americano/fisiologia , Transtornos do Sono-Vigília/epidemiologia , Adulto , Antropometria , Nível de Alerta , Austrália/epidemiologia , Distúrbios do Sono por Sonolência Excessiva/epidemiologia , Humanos , Perna (Membro)/fisiologia , Masculino , Movimento , Polissonografia , Prevalência , Respiração , Síndrome das Pernas Inquietas/epidemiologia , Apneia Obstrutiva do Sono/epidemiologia , Distúrbios do Início e da Manutenção do Sono/epidemiologia , Ronco/epidemiologia , Inquéritos e Questionários , Adulto Jovem
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