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1.
Medicine (Baltimore) ; 99(6): e18938, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32028403

RESUMO

RATIONALE: Behçet's disease (BD) is an inflammatory disease that leads to multisystemic immune dysfunction and that involves pulmonary system alterations. PATIENT CONCERNS: A 26-year-old woman presented with dull right chest pain for 30 days and intermittent cough with expectoration for 5 days. She had a history of recurrent oral ulcer and constitutional rash 2 months prior. DIAGNOSES: The patient was diagnosed with BD complicated by IPA and Aspergillus auriculatus infection. INTERVENTIONS: The patient was administered itraconazole oral solution (200 mg b.i.d) to treat the fungal infection. After a diagnosis of BD was made, she received 40 mg of methylprednisolone sodium succinate daily for 1 week.Then, she also received 24 mg of methylprednisolone sodium succinate daily, which was decreased by 2 mg per half month, until the rash had resolved. The patient continued to receive 200 mg Q. D itraconazole orally for 3 months. Thereafter, itraconazole was stopped, while daily oral administration of 10 mg of methylprednisolone sodium succinate was continued. OUTCOMES: The rash was observed to resolve, and CT revealed that the lesions in both the right and left lung were reduced. During a telephone follow-up performed after 6 months, the patient stated that no symptoms had recurred during the follow-up period. LESSONS: This case illustrates that for patients with BD, ignoring extrapulmonary symptoms often leads to a delayed diagnosis. Physicians should perform a thorough medical history and physical examination of these patients, as the information obtained in this manner may provide important clues for disease diagnosis and treatment.


Assuntos
Aspergillus/isolamento & purificação , Síndrome de Behçet/diagnóstico , Aspergilose Pulmonar Invasiva/diagnóstico , Adulto , Antifúngicos/administração & dosagem , Antifúngicos/uso terapêutico , Síndrome de Behçet/complicações , Síndrome de Behçet/tratamento farmacológico , Dor no Peito/etiologia , Tosse/etiologia , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Humanos , Aspergilose Pulmonar Invasiva/complicações , Aspergilose Pulmonar Invasiva/diagnóstico por imagem , Aspergilose Pulmonar Invasiva/tratamento farmacológico , Itraconazol/administração & dosagem , Itraconazol/uso terapêutico , Metilprednisolona/administração & dosagem , Metilprednisolona/uso terapêutico , Tomografia Computadorizada por Raios X
2.
Medicine (Baltimore) ; 98(52): e18443, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876725

RESUMO

The purpose of our study was to investigate the diagnostic value of NLR, hemoglobin (HB) and combine NLR with HB in the BD patients.Sixty-seven patients with BD were diagnosed in the rheumatology or dermatology between June 2015 and June 2019; 92 matching healthy physical examiners were included in our study. SPSS was used for statistical analysis.Compared with the healthy control, NLR was increased (P < .001), while the HB level was decreased (P < .001) in the patients of BD. In addition, ESR and CRP were increased in BD patients. NLR has no relationship with CRP and ESR, while the HB levels were negatively correlated with CRP and ESR (r = -0.293, P = .046; r = -0.431, P = .002). ROC curve analysis revealed the AUC of NLR and HB were 0.797 and 0.798 (P < .001). When combined NLR with HB, the AUC was 0.897 (P < .001). Besides, logistic regression analysis demonstrated that NLR and HB were independent risk factors in the BD patients.We observed that the diagnostic value of NLR, HB and combined NLR with HB in the BD patients were high, particularly when combine NLR with HB. NLR and HB were independent risk factors in the BD patients. In addition, HB levels related to the disease activity of BD patients.


Assuntos
Síndrome de Behçet/diagnóstico , Hemoglobinas/análise , Contagem de Linfócitos , Linfócitos , Neutrófilos , Adulto , Síndrome de Behçet/sangue , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
3.
Arch. argent. pediatr ; 117(6): 644-647, dic. 2019. ilus
Artigo em Inglês, Espanhol | LILACS, BINACIS | ID: biblio-1046628

RESUMO

La enfermedad de Behçet (EB) es un trastorno de vasculitis sistémica poco frecuente, de etiología desconocida, que se caracteriza por la presencia de aftas bucales, úlceras genitales y uveítis recurrentes. Afecta los sistemas nerviosos central y periférico; raramente se produce durante la niñez. La meningitis aséptica aguda aislada es muy poco frecuente. En este artículo, se describe el caso de una paciente de 14 años con diagnóstico de enfermedad de Behçet con afectación neurológica (neuro-Behçet). La paciente tenía cefalea aguda, diplopia, papiledema e irritación meníngea. Tenía antecedentes de úlceras bucales recurrentes. Las imágenes por resonancia magnética de cerebro revelaron paquimeningitis. Los hallazgos en el líquido cefalorraquídeo fueron pleocitosis y aumento de la presión. Pese al tratamiento médico, sus síntomas no se resolvieron. No se detectó uveítis y la prueba de patergia fue negativa. El alelo HLA-B51 fue positivo. Se consideró que los hallazgos apuntaban a la poco frecuente enfermedad de Behçet con afectación neurológica. La paciente mejoró drásticamente luego del tratamiento con corticoesteroides. En el diagnóstico diferencial de meningitis, se debe considerar la EB, a menos que se demuestre la presencia de un agente infeccioso. Hasta donde sabemos, anteriormente no se había descrito un caso de paquimeningitis con neuro-Behçet en la población pediátrica.


Behçet's disease (BD) is a rare systemic vasculitis disorder of unknown etiology characterized by recurrent oral and genital apthae and uveitis. It involves the central or peripheral nervous system; occurs rarely during childhood. Isolated acute aseptic meningitis is extremely uncommon. We report here a case of Neuro-Behçet disease (NBD) diagnosed in a 14-year-old girl. The patient presented acute headache, diplopia, papilla edema, and meningeal irritation. She had a history of recurrent oral ulcers. Brain magnetic resonance imaging revealed pachymeningitis. Pleocytosis and pressure increase were the cerebrospinal fluid findings. Although medical therapy, her complaints were not resolved. Uveitis was not detected, pathergy test was negative. HLA-B51 allele was positive. The findings were considered to unusual NBD. The patient improved dramatically after steroid therapy. BD should be considered in differential diagnosis of meningitis unless an infectious agent is demonstrated. To our knowledge, a case of pachymeningitis with NBD, was not described in children.


Assuntos
Humanos , Feminino , Adolescente , Síndrome de Behçet/diagnóstico , Corticosteroides/administração & dosagem , Cefaleia , Meningite Asséptica/diagnóstico
4.
Clin Exp Rheumatol ; 37 Suppl 121(6): 3-17, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31856939

RESUMO

Several epidemiologic studies report on the prevalence of Behçet's syndrome (BS) and demographic and clinical findings in patients from different countries and ethnicities. Although these studies point out geographic differences in disease course, methodologic differences make it difficult to compare the results of these studies. Recent data suggest that neutrophil extracellular trap levels are elevated in patients with BS, and that it may be a potential therapeutic target for the reduction or prevention of BS-associated thrombotic risk. Details on the mode of functioning of ERAP have been delineated and further epigenetic data reported. Wall thickness of lower extremity veins is increased among BS patients without any apparent clinical involvement. Magnetic resonance (MR) venography and Doppler ultrasonography (USG) were comparable in the diagnosis of chronic deep vein thrombosis, while MR venography is more effective in detecting collateral formations. Results were also collected on some dietary and non-dietary factors in triggering oral ulcers, while smoking seems to have a protective role. With regards to the therapy, it has been demonstrated that endovascular interventions carry the risk of inducing pathergy phenomenon. Apremilast has been convincingly shown to be useful for oral ulcers of BS and classical immunosuppressives are effective as first line therapy in more than half of patients with uveitis. While infliximab and adalimumab seem to be equally effective in the treatment of refractory uveitis of BS, the combination of adalimumab and immunosuppressives appears to be superior to immunosuppressives alone for venous thrombosis of the extremities. In addition, tocilizumab might be an alternative to anti-TNF agents for patients with arterial involvement refractory to immunosuppressives. On the other hand, the place of IL-17 inhibition in the treatment of BS still remains questionable.


Assuntos
Síndrome de Behçet , Imunossupressores/uso terapêutico , Adalimumab , Síndrome de Behçet/complicações , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/tratamento farmacológico , Predisposição Genética para Doença , Humanos , Úlceras Orais/etiologia , Prevalência , Fator de Necrose Tumoral alfa/uso terapêutico , Uveíte/etiologia , Trombose Venosa/etiologia
5.
Pan Afr Med J ; 33: 194, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31692738

RESUMO

Mass lesions of the brain are not always a tumor. We report the case of a patient followed for Behcet syndrome presenting with expansive intracranial process revealed by right hemiparesis associated with signs of intracranial hypertension. Brain magnetic resonance imaging (MRI) showed a lesion suggesting glial tumor. Clinical and radiological assessments as well as laboratory tests helped to establish the diagnosis of pseudo-tumor form of neuro-Behçet disease. This study report is followed by a clinical analysis based on the available literature on this disorder.


Assuntos
Síndrome de Behçet/diagnóstico , Neoplasias Encefálicas/diagnóstico , Pseudotumor Cerebral/diagnóstico , Síndrome de Behçet/complicações , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade
7.
Medicine (Baltimore) ; 98(46): e17979, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31725663

RESUMO

RATIONALE: Intestinal Behçet disease (BD) with myelodysplastic syndrome (MDS) is a rare condition that is resistant to various immunosuppressive therapies. Several cases in which hematopoietic stem cell transplantation (HSCT) was effective for intestinal BD with MDS accompanying trisomy 8 have been reported. PATIENT CONCERNS: We report an 18-year-old female with a 7-year history of BD. Colonoscopy demonstrated a huge ulcer in the cecum. Chromosomal examination revealed a karyotype of trisomy 8 in 87% of cells. Bone marrow examination revealed dysplastic cells in multilineages. DIAGNOSES: A diagnosis of intestinal BD associated with MDS accompanying trisomy 8 was made. INTERVENTIONS: The patient underwent ileocecal resection due to microperforations of ileocecal ulcers; she then underwent allogeneic peripheral blood stem cell transplantation (PBSCT) with her mother as a donor. OUTCOMES: After the PBSCT, the patient's symptoms due to BD (fever, oral aphthae, abdominal pain, and genital ulcers) completely disappeared, with no severe adverse events. LESSONS: The present case demonstrates that HSCT including PBSCT might be an effective new therapeutic option for refractory intestinal BD with MDS when immunosuppressive therapy has achieved insufficient efficacy.


Assuntos
Síndrome de Behçet/complicações , Síndrome de Behçet/terapia , Síndromes Mielodisplásicas/complicações , Trissomia/patologia , Adolescente , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/cirurgia , Cromossomos Humanos Par 8 , Feminino , Transplante de Células-Tronco Hematopoéticas/métodos , Humanos , Síndromes Mielodisplásicas/diagnóstico
8.
J Assoc Physicians India ; 67(8): 77-79, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31562726

RESUMO

We report a case of a 25 year old patient with history of recurrent oral aphthous ulcers and genital ulcers and phylectenular conjunctivitis presenting to us with sudden onset of cough and difficulty in breathing diagnosed as Behcets disease with pulmonary embolism. A rapid and precise diagnosis and treatment of this patient led to good recovery of this patient. Pulmonary thromboembolism is a rare complication of Behcets disease.


Assuntos
Síndrome de Behçet/diagnóstico , Adulto , Humanos , Estomatite Aftosa , Úlcera
9.
J Med Vasc ; 44(5): 344-349, 2019 Sep.
Artigo em Francês | MEDLINE | ID: mdl-31474346

RESUMO

Behçet's disease (BD) is a systemic vasculitis diagnosed on the basis of clinical criteria established by the International Study Group for Behçet's. Vascular involvement is common, affecting both arteries and veins. Aortic localizations are rare and severe and can be life-threatening in case of rupture. Thrombosis is observed but aneurysm or false aneurysm are more common. Computed tomographic angiography is essential for diagnosis and study of the characteristics of aneurysms and false aneurysms. Treatment relies on corticosteroids and immunosuppressive drugs in severe forms supplemented by open or endovascular repair. This latter approach represents a safe and efficient alternative to open surgery, it induces fewer pseudoaneurysms and increases the survival rate especially in association with immunosuppressors. We report a case of Behçet disease revealed by a false aneurysm of the abdominal aorta treated by deployment of a covered stent.


Assuntos
Falso Aneurisma/etiologia , Aneurisma da Aorta Abdominal/etiologia , Síndrome de Behçet/complicações , Falso Aneurisma/diagnóstico por imagem , Falso Aneurisma/terapia , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Aneurisma da Aorta Abdominal/terapia , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/tratamento farmacológico , Procedimentos Endovasculares/instrumentação , Humanos , Imunossupressores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Stents , Resultado do Tratamento
10.
In Vivo ; 33(5): 1493-1497, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31471397

RESUMO

BACKGROUND/AIM: Neurological symptoms (neuro-Behçet's disease; NBD) occur in a fraction of Behçet's disease (BD) patients and often present with parenchymal brain lesions and clinical exacerbations. Our aim was to identify genes associated with attack and remission periods of NBD. MATERIALS AND METHODS: Microarray analysis was performed using peripheral blood mononuclear cell (PBMC) samples obtained during attack and remission periods of five NBD patients. Expression levels of the most significantly up-regulated genes were measured with real-time PCR using PBMC samples of 15 NBD patients and 20 healthy controls. RESULTS: During NBD attacks, the most remarkably up-regulated genes were defensin alpha 1B (DEFA1B) and NLR family, pyrin domain containing 3 (NLRP3). Real time PCR studies showed significantly increased DEFA1B and NLRP3 expression levels during attacks. CONCLUSION: Immunological factors showing the most significant increase in expression during NBD attacks were primarily associated with innate immunity functions. DEFA1B and NLRP3 can be used as biomarkers for estimation of disease activity in NBD.


Assuntos
Síndrome de Behçet/diagnóstico , Síndrome de Behçet/etiologia , Expressão Gênica , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Fenótipo , alfa-Defensinas/genética , Biomarcadores , Progressão da Doença , Feminino , Humanos , Leucócitos Mononucleares/metabolismo , Imagem por Ressonância Magnética , Masculino , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Índice de Gravidade de Doença , Sequenciamento Completo do Genoma , alfa-Defensinas/metabolismo
11.
Ann R Coll Surg Engl ; 101(8): e164-e168, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31537109

RESUMO

Neuro-Behçet's disease (NBD) is a serious manifestation of Behçet's disease (BD) and can affect either the central or peripheral nervous systems, or both. It occurs in 10-50% of patients with BD. We report on a patient with an unusual intraparenchymal lesion, initially thought to be a brain tumour. Histological examination revealed vasculitis consistent with BD. Clinicians should include NBD as a differential diagnosis when considering an isolated inflammatory intracranial lesion.


Assuntos
Síndrome de Behçet/diagnóstico , Granuloma de Células Plasmáticas/diagnóstico , Adulto , Síndrome de Behçet/complicações , Síndrome de Behçet/patologia , Biópsia , Encéfalo/patologia , Neoplasias Encefálicas/diagnóstico , Diagnóstico Diferencial , Granuloma de Células Plasmáticas/etiologia , Granuloma de Células Plasmáticas/patologia , Humanos , Imagem por Ressonância Magnética , Masculino
12.
Clin Exp Rheumatol ; 37 Suppl 121(6): 147-151, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31376249

RESUMO

OBJECTIVES: To report our experiences of the juvenile Behçet's disease (BD) patients with cerebral venous sinus thrombosis (CVST) and to review previous studies reporting the clinical characteristics and outcomes of juvenile BD with CVST. METHODS: Clinical characteristics and outcomes of paediatric patients with CVST who met the Paediatric Behçet's Disease (PEDBD) classification criteria for juvenile BD from 3 referral centres in Turkey were reviewed retrospectively. A systematic review of literature of all published data was conducted. RESULTS: The study group consisted of 12 juvenile BD patients with CVST. At the time of CVST diagnosis, the most common symptom was headache (100%), followed by vomiting (25%), blurred vision (16.7%), and disturbances in eye movements (16.7%). Six (50%) patients presented with CVST. Transverse sinus was the most frequently affected sinus (9/12, 75%) followed by superior sagittal sinus. The mean (±2SD) BDCAF at the CVST diagnosis was 6 (±3.8). Four children (33.3%) had another venous thrombosis apart from CVST. All patients received pulse methylprednisolone for three consecutive days continued with oral prednisolone. Steroid treatment was tapered and discontinued minimum in six months. Eleven patients received azathioprine concomitant to steroid treatment at the time of CVST. All the patients received anticoagulant therapy concomitantly. Only one patient who did not receive azathioprine relapsed. Median follow-up period was 4 years (IQR: 2-5.4). In the literature review, we identified nine articles, describing 35 pediatric CVST patients associated with BD. Thirty patients achieved remission, while five patients had residual neurologic deficit. CONCLUSIONS: Neuroimaging is very important in the diagnosis of NBD. We suggest that treatment with immunosuppressants and steroid treatment is essential to decrease the adverse events of corticosteroids in the pediatric population and decrease relapses. Further multicenter studies with prospective follow-up may guide us in better management of these patients.


Assuntos
Síndrome de Behçet , Trombose dos Seios Intracranianos , Trombose Venosa , Adolescente , Síndrome de Behçet/complicações , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/tratamento farmacológico , Criança , Humanos , Estudos Prospectivos , Estudos Retrospectivos , Trombose dos Seios Intracranianos/diagnóstico , Trombose dos Seios Intracranianos/tratamento farmacológico , Turquia , Trombose Venosa/diagnóstico , Trombose Venosa/tratamento farmacológico
13.
Dermatology ; 235(5): 407-412, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31288224

RESUMO

BACKGROUND: Familial aggregation in Behçet's disease (BD) has been reported in Turkish and Japanese populations. While the frequency of familial cases has been reported to be 2-5% worldwide, this rate reaches up to 15% in the Middle East. OBJECTIVE: This study aimed to determine the incidence of familial BD cases followed in the BD polyclinic and to compare their clinical and demographic characteristics to those observed in sporadic cases. METHODS: Data related to BD patients who were followed between 1995 and 2014 were collected from computerized archive records and were assessed for detailed family histories. Only first-degree relatives (brother, sister, mother, father, children) were considered to be cases of familial BD. Clinical and demographic -features were retrieved. Our BD polyclinic is located in the Southeast Marmara Region in Turkey. RESULTS: BD was detected in 36 first-degree relatives of 33 patients out of 840 patients with BD. A total of 45 patients were diagnosed as familial BD;23 were female, and 22 were male. In our patients, the incidence of familial BD was determined to be 3.9%. The rates for HLA-B5 positivity, ocular involvement, genital ulcers, and erythema nodosum were determined to be 86.6% (26/30), 26.6%, 82.2%, and 60%, respectively. None of the patients had neurological involvement, but 2 had vascular involvement. CONCLUSION: This study may contribute to the epidemiological data of BD from Turkey.


Assuntos
Síndrome de Behçet/diagnóstico , Síndrome de Behçet/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Síndrome de Behçet/complicações , Síndrome de Behçet/genética , Feminino , Antígenos HLA-B/genética , Humanos , Masculino , Pessoa de Meia-Idade , Turquia/epidemiologia , Adulto Jovem
14.
J Vasc Surg ; 70(3): 937-940, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31327604

RESUMO

Behçet disease is a multisystem disorder presenting with recurrent oral and genital ulcerations as well as with ocular involvement. Vascular involvement can occur in up to 50% of affected patients. Arterial aneurysms are often multiple and are characterized by a saccular configuration with increased risk of unexpected rupture, thrombosis, and aneurysm recurrence. Here we report a case of giant infrarenal abdominal aortic aneurysm in a 34-year-old man with Behçet disease who underwent aneurysmorrhaphy and aortobifemoral bypass.


Assuntos
Aneurisma da Aorta Abdominal/etiologia , Síndrome de Behçet/complicações , Adulto , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Aneurisma da Aorta Abdominal/cirurgia , Síndrome de Behçet/diagnóstico , Implante de Prótese Vascular , Humanos , Ligadura , Masculino , Resultado do Tratamento
15.
J Dermatol ; 46(10): 907-910, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31353537

RESUMO

Generalized pustular psoriasis (GPP) is now known to be caused by biallelic variants in IL36RN and monoallelic variants in CARD14 and AP1S3. The presence of a modifier locus or oligogenic inheritance have been hypothesized. We report on a patient with a unique coinheritance of pathogenic variants in IL36RN (c.115+6T>C) and TNFAIP3 (c.547C>T, p.R183*) causing the genetic entities GPP and familial Behçet-like autoinflammatory syndrome (AISBL). The heterozygous variant in IL36RN identified by Sanger sequencing was inherited from his unaffected father, while the heterozygous variant in TNFAIP3 was detected by whole-exome sequencing and was also identified in the patient's AISBL-affected maternal relatives. Further functional studies are required to research whether the variant of TNFAIP3 plays a part in the development of GPP or simply causes the Behçet's disease phenotype. However, our data suggest that whole-exome sequencing for the heterozygous carrier of the IL36RN gene in GPP be used to find the potential second genetic locus.


Assuntos
Síndrome de Behçet/genética , Interleucinas/genética , Psoríase/genética , Proteína 3 Induzida por Fator de Necrose Tumoral alfa/genética , Grupo com Ancestrais do Continente Asiático , Síndrome de Behçet/diagnóstico , Pré-Escolar , Predisposição Genética para Doença , Heterozigoto , Humanos , Masculino , Herança Multifatorial , Mutação , Linhagem , Psoríase/diagnóstico
17.
Int J Immunogenet ; 46(5): 339-341, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31183983

RESUMO

A novel nonsynonymous variation of NLRP3 was identified in an Italian patient with Behçet syndrome using both bioinformatics and molecular methods. This variation was a thymine to guanine polymorphism responsible for the isoleucine to serine amino acid change at position 348. The novel variation was predicted to be a pathogenic allele.


Assuntos
Síndrome de Behçet/diagnóstico , Síndrome de Behçet/genética , Estudos de Associação Genética , Predisposição Genética para Doença , Variação Genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/genética , Alelos , Sequência de Bases , Análise Mutacional de DNA , Estudos de Associação Genética/métodos , Genótipo , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético
18.
Eur Arch Otorhinolaryngol ; 276(10): 2691-2696, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31214827

RESUMO

OBJECTIVE: The aim of this study is to evaluate sensorineuralhearing loss (SHNL) and tinnitus in patients with Behcet's disease (BD), while also determining the association between the clinical symptoms of BD and the disease duration with the development of hearing loss. MATERIALS AND METHODS: The study included 44 patients with BD and 42 healthy volunteers as the control group. The level of tinnitus-induced annoyance and the effects of tinnitus on daily life were evaluated with Visual Analog Scale (VAS) and the Tinnitus Reaction Questionnaire (TRQ). The hearing levels of all participants were measured with high-frequency audiometry and transient auto-acoustic emission tests. RESULTS: The patients with BD were significantly more affected by SNHL and tinnitus than the controls (p < 0.05). The correlation between disease duration and age among those with SNHL was statistically significant (p < 0.05). No association was found between the clinical findings and SNHL and tinnitus (p > 0.05) in the BD patients. CONCLUSION: In the present study, high-frequency SNHL was found to be common in among the patients with BD. SNHL in BD is positively correlated with the patients' age of the and the disease duration.


Assuntos
Síndrome de Behçet/complicações , Perda Auditiva Neurossensorial/diagnóstico , Zumbido/diagnóstico , Adulto , Fatores Etários , Audiometria de Tons Puros/métodos , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/fisiopatologia , Feminino , Perda Auditiva Neurossensorial/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Avaliação de Sintomas/métodos , Fatores de Tempo , Zumbido/etiologia , Escala Visual Analógica
19.
J Med Vasc ; 44(4): 295-298, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31213303

RESUMO

BACKGROUND: Prolonged fever (PF) is a challenging problem for physicians since it can be the first manifestation of a large variety of pathologies. Exceptionally, intra-cardiac thrombus (ICT) could explain PF and reveal Behçet's disease (BD). We are reporting a 45-year-old man with BD who has these unusual manifestations. CASE REPORT: A 45-year-old man presented with PF and inflammatory biological syndrome during a few months. Echocardiography showed an inhomogeneous and mobile mass in the left auricle. During his hospitalization, the patient had multiple oral aphtosis. The angioscanner showed a sacciform aneurysm of the coeliac trunk. The diagnosis of BD was retained and he was treated with high doses of steroids and cyclophosphamide with a favorable follow-up. CONCLUSION: The search for BD should be systematic in view of any suggestive manifestation of severe cardiovascular complications like ICT especially in a young adult man from a high endemicity region.


Assuntos
Síndrome de Behçet/complicações , Febre/etiologia , Cardiopatias/etiologia , Trombose/etiologia , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/tratamento farmacológico , Ciclofosfamida/administração & dosagem , Febre/diagnóstico , Glucocorticoides/administração & dosagem , Cardiopatias/diagnóstico por imagem , Humanos , Imunossupressores/administração & dosagem , Masculino , Pessoa de Meia-Idade , Trombose/diagnóstico por imagem , Resultado do Tratamento
20.
Clin Dermatol ; 37(3): 227-239, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31178105

RESUMO

Behçet syndrome is considered to be a multisystemic vasculitis involving the skin, mucosa, eyes, joints, nervous system, cardiovascular system, and gastrointestinal system. The exact pathogenesis of the disease is unknown, but autoimmune factors are thought to play the main role. Vasculitis in Behçet syndrome can involve any kind and size of vessels, and this explains why the disease has the ability of multisystemic involvement. The commonest clinical presentation of Behçet syndrome is recurrent and painful mucocutaneous ulcerations known as aphthosis. The other clinical manifestations vary among patients and populations. The disease tends to be more severe in men. Ocular, vascular, and central nervous system involvements are the major causes of morbidity and mortality. Behçet syndrome is a mimicker of many diseases with its several faces and considered as one of the great imitators in dermatology.


Assuntos
Síndrome de Behçet , Administração Tópica , Corticosteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/administração & dosagem , Autoimunidade , Azatioprina/administração & dosagem , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/tratamento farmacológico , Síndrome de Behçet/imunologia , Síndrome de Behçet/patologia , Fatores Biológicos/administração & dosagem , Colchicina/administração & dosagem , Diagnóstico Diferencial , Erros de Diagnóstico/prevenção & controle , Humanos , Imunossupressores/administração & dosagem , Membrana Mucosa/patologia , Recidiva , Estomatite Aftosa/etiologia , Estomatite Aftosa/patologia , Tacrolimo/administração & dosagem , Tacrolimo/análogos & derivados , Fator de Necrose Tumoral alfa/antagonistas & inibidores
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