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1.
An Bras Dermatol ; 95(1): 57-62, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31889592

RESUMO

BACKGROUND: Sarcoidosis is a multisystem disease of unknown cause that is characterized by the presence of granulomas in various organs. Cutaneous involvement is common and the reported incidence has varied from 9% to 37%. Studies on cutaneous sarcoidosis in Brazil are lacking. OBJECTIVES: To describe the clinical and epidemiological aspects of patients with cutaneous sarcoidosis diagnosed at the Department of Dermatology of the University of São Paulo, from May 1994 to March 2018. METHODS: Clinical data of patients with confirmed cutaneous sarcoidosis were retrospectively reviewed and classified according to gender, ethnicity, age at diagnosis, cutaneous presentation, systemic involvement and treatment. RESULTS: Cutaneous sarcoidosis was diagnosed in 72 patients with a female predominance (74%). The mean age at diagnosis was 49.6 years and most of the patients were white (61%). Papules and plaques were the most common lesions. Systemic sarcoidosis was detected in 81% of patients, affecting mainly the lungs and thoracic lymph nodes (97%). Typically, cutaneous lesions were the first manifestation (74%). Systemic therapy was necessary for 72% of patients; the dermatologist managed many of these cases. Oral glucocorticoids were the most commonly used systemic medication (92%). The mean number of systemic drugs used was 1.98 per patient. LIMITATIONS: Insufficient data in medical records. CONCLUSIONS: This series highlights the dermatologist role in recognizing and diagnosing cutaneous sarcoidosis, evaluating patients for systemic disease involvement and treating the skin manifestations. Cutaneous sarcoidosis was once considered exceedingly infrequent in Brazil in comparison to infectious granulomatous diseases; however, the present series seems to suggest that the disease is not so rare in this region.


Assuntos
Sarcoidose/epidemiologia , Dermatopatias/epidemiologia , Centros de Atenção Terciária/estatística & dados numéricos , Administração Cutânea , Adulto , Idoso , Brasil/epidemiologia , Fármacos Dermatológicos/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Sarcoidose/tratamento farmacológico , Sarcoidose/patologia , Distribuição por Sexo , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia
2.
Int Braz J Urol ; 46(1): 15-25, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31851454

RESUMO

Sarcoidosis is a multisystem granulomatous disease characterized by epithelioid noncaseating granulomas associated with clinical and radiologic findings. The cause of this disease is still uncertain. Sarcoidosis affects mostly lungs and lymph nodes and is not usually considered a urological disease, therefore, this etiology may be overlooked in several urological disorders, such as hypercalcemia, hypercalciuria and nephrolithiasis. It affects all races and genders. This review aims to describe the urological manifestations of sarcoidosis and to elucidate how the disease may affect the management of numerous urological conditions.


Assuntos
Nefropatias/patologia , Sarcoidose/patologia , Biópsia , Doença Crônica , Humanos , Hipercalcemia/diagnóstico , Hipercalcemia/patologia , Hipercalciúria/diagnóstico , Hipercalciúria/patologia , Nefropatias/diagnóstico , Nefropatias/terapia , Sarcoidose/diagnóstico , Sarcoidose/terapia
3.
Medicine (Baltimore) ; 98(49): e18172, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31804332

RESUMO

RATIONALE: Parotid gland sarcoidosis is a well-recognized, but uncommon disease entity. Parotidectomy is most commonly performed to establish the diagnosis and most patients are treated with corticosteroids. PATIENT CONCERNS: A young female patient presented with right parotid enlargement and developed symptoms of facial nerve palsy during diagnostic investigation. DIAGNOSES: A fine-needle aspiration cytology showed granulomatous inflammation. The diagnosis of sarcoidosis was eventually established based on the demonstration of the characteristic lambda and panda signs by a Gallium-67 scintigraphy. INTERVENTIONS: No specific pharmacologic therapy was initiated. OUTCOMES: The patient's symptoms regressed completely over a period of 3 months. Additionally, she remains asymptomatic 2 years later. LESSONS: This case underlines the importance of not initiating corticosteroids in all patients with parotid gland sarcoidosis and suggests that parotidectomy can be avoided in the presence of characteristic for sarcoidosis imaging findings.


Assuntos
Doenças Parotídeas/patologia , Sarcoidose/patologia , Adulto , Biópsia por Agulha Fina , Feminino , Humanos , Remissão Espontânea
6.
Spine (Phila Pa 1976) ; 44(21): E1248-E1255, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31634300

RESUMO

STUDY DESIGN: A case series of dual time-point F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of spinal cord sarcoidosis. OBJECTIVE: The aim of this study was to illustrate three cases of spinal sarcoidosis with occult presentation and subsequent identification with the use of dual time-point F-FDG PET/CT. SUMMARY OF BACKGROUND DATA: Sarcoidosis of the spinal cord is very rare and when it occurs without systemic manifestations of disease can be a challenging diagnostic dilemma frequently resulting in the need for spinal cord biopsy in order to establish a diagnosis. METHODS: Case series presentation and report. RESULTS: This manuscript presents a case series experience of dual time-point F-FDG PET/CT for the diagnosis of spinal cord sarcoidosis. We review the cases of three patients who presented with myelopathy and underwent F-FDG DTPI as part of the evaluation for enhancing spinal cord lesions of unknown etiology for 2 years at a university-based cancer hospital. F-FDG DTPI was vital in making the diagnosis of sarcoidosis, and in two of the cases, the patients were able to avoid biopsy, thereby avoiding potential morbidity from an invasive procedure. CONCLUSION: F-FDG PET/CT imaging is a noninvasive imaging technique that can be crucial in the diagnosis of sarcoidosis of the spinal cord and help avoid unnecessary procedures. LEVEL OF EVIDENCE: 4.


Assuntos
Fluordesoxiglucose F18 , Compostos Radiofarmacêuticos , Sarcoidose/diagnóstico por imagem , Doenças da Coluna Vertebral/diagnóstico por imagem , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos , Sarcoidose/patologia , Doenças da Medula Espinal/diagnóstico por imagem , Doenças da Medula Espinal/patologia , Doenças da Coluna Vertebral/patologia
7.
An Bras Dermatol ; 94(4): 470-472, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644624

RESUMO

Paracoccidioidomycosis is a fungal infection that occurs in immunocompetent patients and are classified into two forms: the acute-subacute form, predominantly in young patients, and the chronic adult form that may present classic ulcerated lesions to rare sarcoid ones. We present the case of a boy whose infection began with sarcoid lesions but, after being mistakenly diagnosed with cutaneous sarcoidosis and treated (for three years) with prednisone, developed painful ulcerations throughout the body. After the correct diagnosis, with evidence of the fungus in histopathological and mycological examinations, the patient was properly treated with itraconazole for eight months and evolved with total remission of the disease.


Assuntos
Glucocorticoides/efeitos adversos , Paracoccidioidomicose/etiologia , Paracoccidioidomicose/patologia , Prednisona/efeitos adversos , Adolescente , Antifúngicos/uso terapêutico , Humanos , Itraconazol/uso terapêutico , Masculino , Paracoccidioidomicose/diagnóstico , Paracoccidioidomicose/tratamento farmacológico , Sarcoidose/diagnóstico , Sarcoidose/patologia , Resultado do Tratamento
9.
Pan Afr Med J ; 33: 92, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31489070

RESUMO

Isolated involvement of the hypothalamic-pituitary axis in patients with sarcoidosis is rare. Only a few cases have been reported in the literature. We report the clinical case of a 50-years old female patient who had undergone total thyroidectomy followed by replacement therapy because of goitre 4 years before. She complained of chronic headaches persisting for 6 months and resistant to all appropriate therapies, with concomitant decrease in visual acuity. Clinical examination showed optochiasmatic syndrome with extensive visual field defect and common oculomotor nerve palsy in the right eye with ptosis. Brain MRI objectified pathological process to the sellar region with heterogeneous tissue signal intensity extending to the pituitary stalk with thickening in the latter. Preoperative hormonal assessment showed mild thyrotropic deficiency. The patient underwent wide transnasal endoscopic transsphenoidal resection of fibrous and little bleeding tumor. Postoperative outcome was marked by the occurrence of diabetes insipidus and CSF fistula two days after surgery. Patient's outcome was good under medical treatment with spinal drainage. Thoracoabdominal CT scan and cardiac ultrasound were performed which showed no other site of occurrence of sarcoidosis. Dose of converting enzyme was normal. The patient received corticosteroid therapy for the treatment of systemic disease. Neurosarcoidosis is a criterion of poor prognosis in a patient with sarcoidosis. Hypothalamopituitary involvement is rare resulting in complications which are more frequent than those of other neurological and systemic disorders. This requires multidisciplinary long term management.


Assuntos
Adenoma/diagnóstico , Doenças da Hipófise/diagnóstico , Neoplasias Hipofisárias/diagnóstico , Sarcoidose/diagnóstico , Doenças do Sistema Nervoso Central/diagnóstico , Doenças do Sistema Nervoso Central/patologia , Feminino , Humanos , Imagem por Ressonância Magnética , Doenças da Hipófise/patologia , Prognóstico , Sarcoidose/patologia , Tomografia Computadorizada por Raios X
11.
Ear Nose Throat J ; 98(8): NP120-NP124, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31522556

RESUMO

OBJECTIVES: To describe a unique case of isolated bilateral sarcoidosis of the cerebellopontine angle as well as the related imaging in the case. To conduct a literature review of the published articles regarding sarcoidosis of the cerebellopontine angle. DATA SOURCES: Representative case report from a single institution as well as PubMed and Scopus database searches. METHODS: In addition to a retrospective review, all published case reports and case series of sarcoidosis involving the cerebellopontine angle from 1960 to July 2018 in the English language were reviewed. Demographic data, presenting symptoms, and outcomes were collected. RESULTS: We identified 8 total cases with pertinent clinical information that were included. CONCLUSIONS: Isolated neurosarcoidosis of the cerebellopontine angle is an exceptionally rare phenomenon that, on history and imaging, presents similar to more common retrocochlear pathologies. Surgery may be required in large lesions unresponsive to traditional medical therapy with immunosuppression.


Assuntos
Doenças do Sistema Nervoso Central/diagnóstico por imagem , Doenças do Sistema Nervoso Central/patologia , Neuroma Acústico/diagnóstico por imagem , Sarcoidose/diagnóstico por imagem , Sarcoidose/patologia , Doenças do Sistema Nervoso Central/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Sarcoidose/cirurgia
12.
Arch. Soc. Esp. Oftalmol ; 94(9): 453-459, sept. 2019. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-186226

RESUMO

Se presenta un caso raro de una mujer caucásica de 29 años con un granuloma en una cicatriz antigua, en la región periocular derecha, como primer signo clínico de una sarcoidosis sistémica. Se procedió a una biopsia escisional de la lesión con diagnóstico anatomopatológico de inflamación crónica granulomatosa no necrosante, con características histológicas sugestivas de sarcoidosis de cicatriz. Al año, la lesión recidivó, por lo que se trató con esteroides depot intralesionales. Esta patología se produce con más frecuencia cuando existen cuerpos extraños y puede ser la primera señal de sarcoidosis sistémica


An unusual case is presented of a 29 year-old Caucasian woman with a granuloma in an old scar in the right periocular region as a first clinical sign of a systemic sarcoidosis. An excisional biopsy was performed, for which the histological diagnosis was a chronic non-necrotising granulomatous inflammation, suggestive of scar sarcoidosis. The lesion re-appeared one year after initial treatment, and was treated with intralesional depot steroids, showing adequate progression. This disease occurs more frequently in wound areas where there are foreign bodies and could be the first sign of systemic sarcoidosis


Assuntos
Humanos , Feminino , Adulto , Cicatriz/patologia , Dermatoses Faciais/diagnóstico , Granuloma de Corpo Estranho/patologia , Sarcoidose/diagnóstico , Anti-Inflamatórios/uso terapêutico , Biópsia , Dermatoses Faciais/diagnóstico por imagem , Dermatoses Faciais/patologia , Traumatismos Faciais/complicações , Traumatismos Faciais/patologia , Granuloma de Corpo Estranho/diagnóstico por imagem , Granuloma de Corpo Estranho/etiologia , Imagem por Ressonância Magnética , Recidiva , Sarcoidose/tratamento farmacológico , Sarcoidose/patologia , Sarcoidose Pulmonar/complicações , Sarcoidose Pulmonar/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Triancinolona Acetonida/uso terapêutico , Cicatrização
13.
J Dermatol ; 46(10): 917-921, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31392741

RESUMO

While the etiology of sarcoidosis remains uncertain, mycobacteria have been suggested as a causative infectious agent. To investigate the causal relationship between mycobacteria and sarcoidosis, we performed a reverse blot hybridization assay (REBA) to identify mycobacteria from the skin samples of nine patients with sarcoidosis. Six of the nine samples were shown to be positive for mycobacteria by REBA, including Mycobacterium tuberculosis and non-tuberculous mycobacteria. This is the first study to identify mycobacteria from the skin samples of sarcoidosis patients using REBA, and our results could strengthen the etiologic association between mycobacteria and sarcoidosis.


Assuntos
Mycobacterium tuberculosis/isolamento & purificação , Micobactérias não Tuberculosas/isolamento & purificação , Sarcoidose/microbiologia , Dermatopatias/microbiologia , Pele/microbiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Sondas de DNA , DNA Bacteriano/isolamento & purificação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Técnicas de Sonda Molecular , Mycobacterium tuberculosis/genética , Micobactérias não Tuberculosas/genética , Reação em Cadeia da Polimerase , Sarcoidose/patologia , Pele/patologia , Dermatopatias/patologia
14.
BMC Pulm Med ; 19(1): 155, 2019 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-31429741

RESUMO

BACKGROUND: Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary disease. Previous studies have established the utility of EBUS-TBNA in narrowly defined indications and populations. In this pragmatic 'real world' study we have analysed the use of EBUS-TBNA for a variety of clinical presentations and its clinical application in conjunction with other invasive investigations. METHODS: All EBUS-TBNA procedures performed at Sir Charles Gardiner Hospital in 2012-2014 were reviewed retrospectively, using relevant hospital databases. RESULTS: A total of 327 patients underwent 337 EBUS-TBNA procedures. EBUS-TBNA procedures were used to diagnose a wide spectrum of benign and malignant conditions. The main application was in the diagnosis and staging of malignant conditions (70.6%), and in the diagnosis of benign conditions such as sarcoidosis 40 (12.2%), and silicoanthracosis 17 (5.2%). EBUS-TBNA was sufficient to diagnose and stage the disease as a single stand-alone invasive procedure in 191 (59.2%) patients. EBUS-TBNA was the final invasive procedure undertaken in 283 (87.6%) patients. Only 13.3% of non small cell lung cancer (NSCLC) patients who had EBUS-TBNA as a first investigation required multiple procedures compared to 51.1% of all NSCLC patients undergoing EBUS-TBNA. Overall sensitivity, specificity, NPV and diagnostic accuracy for EBUS-TBNA were 89.7, 100, 85.1 and 89.9%, respectively and three minor complications (0.9%) occurred as a result of the procedure. CONCLUSIONS: EBUS-TBNA was undertaken for a wide variety of clinical conditions. Good diagnostic accuracy and safety profiles were demonstrated for the procedure, supporting its application as a first line investigation in the diagnosis and/or staging of a range of malignant and benign conditions. Our study was unique in its documentation of the use of EBUS-TBNA in a real-world setting in conjunction with other invasive modalities. EBUS-TBNA was utilised as a stand alone invasive procedure in more than half of the patients. Importantly, in NSCLC, when EBUS-TBNA was performed as primary diagnostic and staging investigation, less patients underwent subsequent invasive procedures.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/patologia , Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico/estatística & dados numéricos , Pneumopatias/patologia , Neoplasias Pulmonares/patologia , Sarcoidose/patologia , Idoso , Austrália , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Bases de Dados Factuais , Feminino , Humanos , Pneumopatias/diagnóstico , Neoplasias Pulmonares/diagnóstico , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Sarcoidose/diagnóstico , Sensibilidade e Especificidade , Silicose/diagnóstico , Silicose/patologia
15.
World J Surg Oncol ; 17(1): 151, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31462247

RESUMO

BACKGROUND: While calcification of thymoma is common, "eggshell" calcification is rare. We report a case of an eggshell calcified thymoma that "hatched" after 4 years of follow-up. Pathologically, it revealed that sarcoidosis accompanied this case of thymoma, which might cause in calcification. CASE PRESENTATION: The patient was a 68-year-old female. A 20-mm anterior mediastinal nodule completely covered with calcification was noted in an annual health check-up. However, as the nodule did not change during 6 months of follow-up, she discontinued regular examinations. Four years later, an abnormality in her chest X-ray was noted again. The tumor grew outside the calcification to reach 63 mm. She underwent resection of this anterior mediastinal tumor. Pathologically, the tumor was diagnosed as thymoma of type B1 in the WHO classification. The histology of the tumor inside and outside of the calcification was not different, suggesting that the tumor grew from the inside of the calcification. The calcification was located within the fibrotic capsule of thymoma. Sarcoidosis also presented in her lung and mediastinal lymph nodes. CONCLUSIONS: Although the mechanism of calcification of the capsule was not clear, sarcoidosis might be related to this case because macrophage accumulation and altered lipid metabolism in sarcoidosis present with similar dystrophic calcification.


Assuntos
Calcinose/patologia , Neoplasias do Mediastino/patologia , Sarcoidose/patologia , Timoma/patologia , Neoplasias do Timo/patologia , Idoso , Calcinose/complicações , Calcinose/cirurgia , Feminino , Humanos , Neoplasias do Mediastino/complicações , Neoplasias do Mediastino/cirurgia , Prognóstico , Sarcoidose/complicações , Sarcoidose/cirurgia , Timoma/complicações , Timoma/cirurgia , Neoplasias do Timo/complicações , Neoplasias do Timo/cirurgia
16.
An. bras. dermatol ; 94(4): 470-472, July-Aug. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1038288

RESUMO

Abstract: Paracoccidioidomycosis is a fungal infection that occurs in immunocompetent patients and are classified into two forms: the acute-subacute form, predominantly in young patients, and the chronic adult form that may present classic ulcerated lesions to rare sarcoid ones. We present the case of a boy whose infection began with sarcoid lesions but, after being mistakenly diagnosed with cutaneous sarcoidosis and treated (for three years) with prednisone, developed painful ulcerations throughout the body. After the correct diagnosis, with evidence of the fungus in histopathological and mycological examinations, the patient was properly treated with itraconazole for eight months and evolved with total remission of the disease.


Assuntos
Humanos , Masculino , Adolescente , Paracoccidioidomicose/etiologia , Paracoccidioidomicose/patologia , Glucocorticoides/efeitos adversos , Paracoccidioidomicose/diagnóstico , Paracoccidioidomicose/tratamento farmacológico , Sarcoidose/diagnóstico , Sarcoidose/patologia , Prednisona/efeitos adversos , Resultado do Tratamento , Itraconazol/uso terapêutico , Antifúngicos/uso terapêutico
18.
Vet Dermatol ; 30(5): 438-e136, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31328338

RESUMO

BACKGROUND: Sarcoidosis is a granulomatous disease histologically characterized by naked granulomas in various mammals. Canine sarcoidosis is a rare disease which can cause nonpruritic papule, plaques and nodules on the trunk, neck, face and ear; it is usually treated with corticosteroids. To date, there are no published reports on alternatives to corticosteroids treatment. OBJECTIVES: To report a case of canine cutaneous sarcoidosis successfully treated with oral ciclosporin. ANIMAL: An 11-year-old beagle dog was presented with multiple pleomorphic plaques on the lateral thighs and dorsal trunk. METHODS AND MATERIALS: Skin punch biopsy specimen were collected and analysed via routine histological examination and immunohistochemistry. After 14 weeks of oral ciclosporin treatment, repeat skin biopsy specimens were collected. RESULTS: Histopathological examination revealed noncaseating epithelioid cell granuloma formation in the dermis. Dermal epithelioid cells were positive for CD18 and Iba1, but not for CD3, CD20 and E-cadherin based on immunohistochemistry findings. Acid-fast bacteria, fungi and Leishmania spp. were not detected by special stains, culture or polymerase chain reaction. An initial two week treatment with immunosuppressive doses of oral prednisolone and doxycycline was not effective. Skin lesions were almost in remission after 14 weeks of oral ciclosporin treatment without adverse events. Histologically, the dermal granulomatous lesions regressed and were replaced by fibrous tissues after ciclosporin treatment. CONCLUSIONS AND CLINICAL RELEVANCE: This case report describes the clinical and histopathological presentation including immunohistochemistry and treatment outcome of a case of canine sarcoidosis Ciclosporin may be an effective alternative to corticosteroids for treating canine sarcoidosis.


Assuntos
Ciclosporina/uso terapêutico , Doenças do Cão/tratamento farmacológico , Imunossupressores/uso terapêutico , Sarcoidose/veterinária , Dermatopatias/veterinária , Animais , Doenças do Cão/patologia , Cães , Feminino , Sarcoidose/tratamento farmacológico , Sarcoidose/patologia , Dermatopatias/tratamento farmacológico , Dermatopatias/patologia
19.
Int J Clin Oncol ; 24(10): 1171-1181, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31321613

RESUMO

Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.


Assuntos
Antineoplásicos Imunológicos/efeitos adversos , Antígeno CTLA-4/antagonistas & inibidores , Pontos de Checagem do Ciclo Celular/efeitos dos fármacos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Granuloma/induzido quimicamente , Neoplasias/tratamento farmacológico , Receptor de Morte Celular Programada 1/antagonistas & inibidores , Sarcoidose/induzido quimicamente , Antígeno CTLA-4/imunologia , Granuloma/patologia , Humanos , Receptor de Morte Celular Programada 1/imunologia , Sarcoidose/patologia
20.
Clin Nucl Med ; 44(10): 824-825, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31274562

RESUMO

A 43-year-old woman, with previous history of renal lithiasis, was admitted on an emergency for severe hypercalcemia fortuitously discovered in a context of rapidly progressive kidney failure. An F-FDG PET/CT performed to rule out underlying malignancy revealed an intense diffuse and isolated muscular FDG uptake with fascia infiltration on the CT finding. A muscular biopsy was performed and demonstrated a non-necrosing granuloma with multinucleated giant cells consistent with muscular sarcoidosis. A corticotherapy was started with a rapid normalization of serum calcium level. The follow-up F-FDG PET/CT 4 months later showed a complete response of the sarcoidosis myositis.


Assuntos
Fluordesoxiglucose F18 , Hipercalcemia/complicações , Músculos/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Sarcoidose/complicações , Sarcoidose/diagnóstico por imagem , Adulto , Biópsia , Feminino , Humanos , Músculos/patologia , Sarcoidose/patologia
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