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1.
Ideggyogy Sz ; 72(5-6): 165-170, 2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31241260

RESUMO

Background and purpose: Two trait-like characteristics, somatosensory amplification and absorption, have been associated with symptom reports and idiopathic environmental intolerances in past research. Purpose - As the two constructs are not connected with each other, their independent contribution to symptom reports and electromagnetic hypersensitivity, as well as their interaction can be expected. Methods: On-line questionnaire. Patients - 506 college students completed an on-line questionnaire assessing absorption, somatosensory amplification, negative affect, somatic symptoms, and electromagnetic hypersensitivity. Results: Somatosensory amplification (ß = 0.170, p < 0.001) and absorption (ß = 0.128, p < 0.001) independently contributed to somatic symptoms after controlling for gender and negative affect (R2 = 0.347, p < 0.001). Similarly, somatosensory amplification (OR = 1.082, p < 0.05) and absorption (OR = 1.079, p < 0.01) independently contributed to electromagnetic hypersensitivity after controlling for somatic symptoms, gender, and negative affect (Nagelkerke R2 = 0.134, p < 0.001). However, no interaction effects were found. Conclusion: Somatosensory amplification and absorption independently contribute to symptom reports and electromagnetic hypersensitivity. Conclusion - The findings suggest that psychological mechanisms underlying symptom reports and electromagnetic hypersensitivity might be heterogeneous.


Assuntos
Ansiedade/psicologia , Campos Eletromagnéticos/efeitos adversos , Sensibilidade Química Múltipla/diagnóstico , Distúrbios Somatossensoriais/psicologia , Estudantes/psicologia , Ansiedade/complicações , Ansiedade/fisiopatologia , Humanos , Sensibilidade Química Múltipla/etiologia , Sensibilidade Química Múltipla/psicologia , Transtornos Somatoformes/psicologia , Distúrbios Somatossensoriais/complicações , Distúrbios Somatossensoriais/fisiopatologia , Inquéritos e Questionários
3.
Med. segur. trab ; 64(251): 217-240, abr.-jun. 2018. tab
Artigo em Espanhol | IBECS | ID: ibc-179779

RESUMO

Introducción: La contaminación y la exposición a productos químicos han condicionado un aumento de la prevalencia de enfermedades crónicas no sólo explicables por la genética o susceptibilidad individual. La Sensibilidad Química Múltiple (SQM) es un ejemplo de estas afecciones. Se trata de un trastorno adquirido, crónico y caracterizado por la aparición de síntomas recurrentes como respuesta a la exposición a compuestos químicos en concentraciones que no se consideran tóxicas para la población general. Su etiología es incierta y multifactorial, su diagnóstico clínico y su abordaje multidisciplinar. En ocasiones está vinculada a la exposición ocupacional, aunque la diversidad de sustancias que pueden desencadenarla la convierten en impredecible. Objetivo: La finalidad de este trabajo es aportar una visión general sobre esta patología con el objetivo de analizar la situación derivada de dicha afección tras la revisión de un caso de SQM. Metodología: Revisión bibliográfica del SQM mediante la búsqueda de literatura científica durante el mes de septiembre de 2017 utilizando los términos Mesh «Multiple Chemical Sensitivity.» Se presenta un caso clínico con diagnóstico de SQM vinculado a exposición ocupacional y se analiza la situación derivada de esta afección. Resultados: Se describe el caso clínico de una trabajadora de 45 años de edad, técnico de laboratorio en un hospital de referencia que tras el diagnóstico de hiperreactividad bronquial probablemente relacionado con la exposición a determinados reactivos comienza un periodo de incapacidad temporal con adaptaciones, cambios de puesto de trabajo y múltiples valoraciones por distintos especialistas hasta llegar al diagnóstico de SQM. Se analiza el informe médico de valoración y el expediente administrativo derivado de esta afección poniendo de manifiesto la dificultad que entraña la valoración de este tipo de patologías. Conclusión: Las peculiaridades del SQM en cuanto etiología, diagnóstico y tratamiento obligan a individualizar cada caso. La subjetividad que rodea el SQM lo convierte en una afección muy difícil de valorar. Uno de los grandes desafíos en la actualidad es continuar investigando para facilitar el abordaje multidisciplinar que requiere esta dolencia


Introduction: Pollution and exposure to chemical products has conditioned an increase in the prevalence of chronic diseases not only explained by genetics or individual susceptibility. The Multiple Chemical Sensitivity (MCS) is an example of these conditions. It is an acquired, chronic disorder identified by recurrent symptoms in response to exposure to chemical compounds at concentrations that are not considered toxic for the general population. Its etiology is uncertain and multifactorial; its diagnosis is clinical and must be multidisciplinary approached. It is sometimes linked to occupational exposure, being unpredictable most of the times due to the diversity of the categories that may trigger it. Objective: The purpose of this work is to provide a general overview of this pathology with the aim of analize the situation derived from this condition reviewing a case of MCS. Methodology: Literature review of the MCS through the search of scientific literature in the month of September 2017 using the terms Mesh «Multiple Chemical Sensitivity». A clinical case with a MCS diagnosis linked to an occupational exposure is presented and the consequences of the condition are analyzed. Results: The clinical case of a 45-year-old female laboratory technician in a reference hospital is described. After the diagnosis of bronchial hyperreactivity, probably related to certain reagents exposure, she begins a period of temporary disability with adaptations, changes in workplace and several valuations by specialized doctors ending with the diagnosis of MCS. The analysis of the medical assessment report and administrative record highlights the difficulty to assess this type of pathologies. Conclusion: The peculiarities of MCS in terms of etiology, diagnosis and treatment make it necessary to individualize each single case. The subjectivity surrounding the SQM makes it a very difficult condition to assess. One of the great challenges nowadays is to continue researching to facilitate the multidisciplinary approach that this ailment requires


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Exposição a Produtos Químicos , Sensibilidade Química Múltipla/complicações , Sensibilidade Química Múltipla/diagnóstico , Hiper-Reatividade Brônquica/induzido quimicamente , Qualidade de Vida , Exposição Ocupacional , Sensibilidade Química Múltipla/etiologia , Hiper-Reatividade Brônquica/complicações
4.
Med. segur. trab ; 64(250): 5-16, ene.-mar. 2018. tab
Artigo em Espanhol | IBECS | ID: ibc-179748

RESUMO

Objetivo: Este trabajo pretende estudiar la relación entre la prevalencia de la SQM, y el hecho de que las personas sean alérgicas, asmáticas o cuenten con piel atópica. Antecedentes: La Sensibilidad química múltiple (SQM) es una enfermedad adquirida cuya etiología sigue siendo desconocida. Se caracteriza por el desarrollo de una sensibilidad a ciertos productos químicos. Método: Para la realización del estudio se analizó la prevalencia de la SQM entre dos colectivos de trabajadores universitarios: el colectivo de investigadores de laboratorios químicos, y el del personal administrativo (sin exposición ocupacional a productos químicos). Ambos grupos trabajan en las mismas universidades y sufren de la misma exposición a la polución ambiental y la proveniente de la construcción de los edificios. Para identificar a los sujetos sensibles se utilizó el Quick Environmental Exposure and Sensitivity Inventory (QEESI) (sensibilidad del 92% /especificidad del 95%). Mientras que para identificar a los sujetos con piel atópica o alérgicos o asmáticos se seleccionó aquellos que habían sido diagnosticados por un médico y que habían sido tratados durante los últimos 10 años. Resultados: Los resultados muestran que los trabajadores con piel atópica, en el conjunto de la población estudiada tanto en los grupos de trabajadores de laboratorio como de trabajadores administrativos, presentan una mayor prevalencia de SQM que el resto. Sin embargo, no se obtienen los mismos resultados con respecto a los trabajadores que padecen alergias o asma. Discusión: Este resultado apunta a que la etiología del síndrome pueda estar relacionado con los mecanismos que generan una piel atópica. Sin embargo, ser alérgico o asmático no presenta relación con la prevalencia de SQM, a pesar de que las personas que padecen alergia o asma tienen una mayor prevalencia de personas con piel atópica. Esto contradice la asociación entre el mecanismo de sensibilización alergénica y la etiología de la SQM


Objective: This paper tries to study the relationship between the prevalence of multiple chemical sensitivities (MSC) and the fact of being allergic, asthmatic or having atopic skin. Introduction: Multiple Chemical Sensitivity (MCS) is an acquired disease of unknown etiology. It is characterized by the development of sensitivity to certain chemical agents. Method: Two groups of university workers were selected for this purpose; university researchers from chemical laboratories and university office workers (with no occupational exposition to chemical agents). Both of them work at the same universities and suffer from the same exposition to the rest of the environmental pollution agents coming from the area and those pollution agents coming from the building construction. In order to determine the MCS prevalence, the Quick Environmental Exposure and Sensitivity Inventory (QEESI) was used (sensitivity of 92% /specificity of 95%). The subjects with atopic skin, allergies or asthma were selected among those medically diagnosed and treated in the last ten years. Results: The results show that the workers with atopic skin (that is, the laboratory studied group and the office workers) display greater prevalence of MCS than the rest among the population studied. However, there were different results coming from workers with allergies or asthma. Discussion: This outcome indicates that there is a possible relation between the etiology of the MCS syndrome and the mechanisms that generate the atopic skin. However, being allergic or asthmatic doesn’t have any relation with the prevalence of MCS, even though people who suffer from allergy or asthma have greater prevalence of atopic skin. Therefore, the results refute the association between the mechanism of allergenic sensitivity and the etiology of MCS


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Exposição Ocupacional , Exposição a Produtos Químicos , Dermatite Atópica/epidemiologia , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/epidemiologia , Asma/epidemiologia , Sensibilidade Química Múltipla/etiologia , Trabalhadores , Inquéritos e Questionários , Laboratórios , Laboratórios/estatística & dados numéricos
5.
Nihon Eiseigaku Zasshi ; 73(1): 1-8, 2018.
Artigo em Japonês | MEDLINE | ID: mdl-29386440

RESUMO

Multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerance, has been described as a chronic acquired disorder characterized by nonspecific symptoms in multiple organ systems and is associated with exposure to low-level chemicals. The name was established by Cullen, in 1987, although the name and diagnostic criteria are still under debate even now. A number of hypotheses concering the etiology and pathogenesis of MCS have been proposed, including impairmens of neurological, immunological and psychological systems. However, research on the possible mechanisms underlying MCS is far from complete. The name and diagnostic criteria of its history as well as theoretical and experimental mechanisms underlying MCS are reviewed here.


Assuntos
Exposição Ambiental/efeitos adversos , Poluição Ambiental/efeitos adversos , Sensibilidade Química Múltipla/etiologia , Adolescente , Adulto , Feminino , História do Século XX , História do Século XXI , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/epidemiologia , Sensibilidade Química Múltipla/história , Adulto Jovem
6.
J Occup Environ Med ; 60(2): 138-146, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29111991

RESUMO

OBJECTIVE: Systematic bibliography analysis of about the last 17 years on multiple chemical sensitivity (MCS) was carried out in order to detect new diagnostic and epidemiological evidence. The MCS is a complex syndrome that manifests as a result of exposure to a low level of various common contaminants. The etiology, diagnosis, and treatment are still debated among researchers. METHOD: Querying PubMed, Web of Science, Scopus, Cochrane library, both using some specific MESH terms combined with MESH subheadings and through free search, even by Google. RESULTS: The studies were analyzed by verifying 1) the typology of study design; 2) criteria for case definition; 3) presence of attendances in the emergency departments and hospital admissions, and 4) analysis of the risk factors. OUTLOOK: With this review, we give some general considerations and hypothesis for possible future research.


Assuntos
Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/epidemiologia , Serviço Hospitalar de Emergência , Hospitalização , Humanos , Estudos Longitudinais , Sensibilidade Química Múltipla/fisiopatologia , Sensibilidade Química Múltipla/psicologia , Estudos Observacionais como Assunto , Fatores de Risco
7.
Rev. Asoc. Esp. Espec. Med. Trab ; 26(4): 271-274, dic. 2017. tab
Artigo em Espanhol | IBECS | ID: ibc-172164

RESUMO

La Sensibilidad Química Múltiple es una entidad controvertida y todavía desconocida. Conocer los criterios diagnósticos y el manejo de los pacientes que la padecen por parte los médicos del trabajo es importante debido a la afectación que puede ocasionar en el ámbito laboral. En este artículo se realiza una revisión de los conocimientos actuales, y sus repercusiones laborales. Se reporta el caso de una trabajadora con sospecha de padecerla y las recomendaciones adaptativas que se realizaron desde el Servicio de Prevención de Riesgos Laborales (AU)


Multiple chemical sensitivity (MCS) is a controversial and little understood entity. It is important for occupational health physicians to know about its diagnostic criteria and understand how to manage patients suffering from MCS because of the significant impact it can have in the work environments. Here we review the current knowledge of MCS and its repercussions in the workplace. We report the case of an employee suspected of having MCS and the adaptive recommendations made by our Occupational Health Service in response to it (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Doenças Profissionais/diagnóstico , Exposição Ocupacional/efeitos adversos , Ambiente de Trabalho/efeitos adversos , Psicometria/instrumentação , Fatores de Risco
8.
Spat Spatiotemporal Epidemiol ; 23: 35-45, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29108689

RESUMO

Multiple chemical sensitivity (MCS) is a chronic condition characterized by recurring and severe symptoms triggered by exposures to low levels of toxicants or anthropogenic pollution. This study investigated the spatial structure of MCS incidence and estimated the contribution of socio-economic deprivation to variations in rates of MCS at the community level in Nova Scotia, Canada. Patient data were used to calculate cumulative incidence rate ratios for treated multiple chemical sensitivities. Poisson regression with a spatially autoregressive random effect was employed to assess spatial variation in MCS. Odds of MSC incidence are greatest among patients from the highest socioeconomic category using the most socioeconomically deprived category as reference (OR: 1.94, CI [2.5-95%] 1.45-2.56). No discernable spatial pattern for MCS risk was evident after controlling for known risk factors. This is the first study to investigate spatial variations in cumulative incidence of multiple chemical sensitivities. The socioeconomic status of the community in which patients live has a significant influence on the geographic patterns of MCS. Future research will include a smartphone application to assess positional and temporal information on environmental exposures to further explain MCS prevalence.


Assuntos
Exposição Ambiental , Sensibilidade Química Múltipla/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Nova Escócia/epidemiologia , Padrões de Prática Médica/estatística & dados numéricos , Prevalência , Encaminhamento e Consulta/estatística & dados numéricos , Fatores de Risco , Análise Espacial , Adulto Jovem
9.
J Appl Physiol (1985) ; 123(5): 1055-1062, 2017 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-28620054

RESUMO

The aim of the study was twofold: first, to compare the activity of the autonomic nervous system (ANS) between the population self-declared as electrohypersensitive (EHS) and their matched control individuals without intended exposure to electromagnetic fields (EMF). The second objective was to determine whether acute exposure to different radiofrequency signals modifies ANS activity in EHS. For that purpose, two different experiments were undertaken, in which ANS activity was assessed through heart rate variability (HRV) and skin conductance (SC). In the first experiment, a comparison between the EHS group (n = 30) and the control group (n = 25) showed that the EHS has an increased number of responses to auditory stimuli as measured by skin conductance activity, and that none of the short-term heart rate variability parameters differ between the two matched study groups. The second experiment, performed in a shielded chamber, involved 10 EHS from the first experiment. The volunteers participated in two different sessions (sham and exposure). The participants were consecutively exposed to four EMF signals (GSM 900, GSM 1800, DECT, and Wi-Fi) at environmental level (1 V/m). The experiment was double blinded and counterbalanced. The HRV variables studied did not differ between the two sessions. Concerning electrodermal activity, the data issued from skin conductance and tonic activity did not differ between the sessions, but showed a time variability. In conclusion, the HRV and SC profiles did not significantly differ between the EHS and control populations under no exposure. Exposure did not have an effect on the ANS parameters we have explored.NEW & NOTEWORTHY This study provided analysis on the skin conductance parameters using a newly developed method (peak/min, extraction of skin conductance responses) that had not been performed previously. Additionally, the skin conductance signal was decomposed, considering tonic and phasic activities to be a distinct compound. Moreover, this is the first time a study has been designed into two steps to understand whether the autonomic nervous system is disturbed in the EHS population.


Assuntos
Sistema Nervoso Autônomo/fisiopatologia , Campos Eletromagnéticos/efeitos adversos , Resposta Galvânica da Pele , Frequência Cardíaca , Coração/inervação , Sensibilidade Química Múltipla/diagnóstico , Exame Neurológico , Pele/inervação , Adulto , Pressão Sanguínea , Estudos de Casos e Controles , Método Duplo-Cego , Condutividade Elétrica , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/etiologia , Sensibilidade Química Múltipla/fisiopatologia , Valor Preditivo dos Testes , Mecânica Respiratória , Fatores de Tempo
10.
Med Clin (Barc) ; 149(4): 141-146, 2017 Aug 22.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-28283271

RESUMO

BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness. PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on patients with a diagnosis of MCS. Data on anthropometric and body composition variables, hand muscle strength and quality of life were collected. The selection of single nucleotide polymorphisms (SNPs) was based on genes previously associated with MCS and genes involved in inflammatory and oxidative stress pathways. RESULTS: A total of 52 patients (93.2% female), with a mean age of 50.9 (10.3) years were included in the study. Among them, based on their BMI, 48% had an inadequate nutritional status (17% were underweight and 32% were overweight or obese). Thirty percent of patients had a low muscle mass for their age, 84% had muscle strength below the tenth percentile, and 51.8% had a high fat mass percentage. Regarding quality of life, all median scores were lower than those of other illnesses assessed for every subscale assessed. Statistically significant differences between patient cases and controls were found with respect to rs1801133 (MTHFR), rs174546 (FADS1) and rs1801282 (PPARγ) polymorphisms. CONCLUSION: A high percentage of patients had a poor nutritional status, low muscle strength and decreased muscle mass. These facts exacerbate the already-lower quality of life of these patients. Specific genetic polymorphisms associated with the syndrome or its pathogenesis were not identified.


Assuntos
Genótipo , Sensibilidade Química Múltipla , Estado Nutricional , Sobrepeso/etiologia , Polimorfismo de Nucleotídeo Único , Qualidade de Vida , Magreza/etiologia , Adulto , Composição Corporal , Estudos Transversais , Feminino , Marcadores Genéticos , Predisposição Genética para Doença , Força da Mão , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/complicações , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/genética , Sensibilidade Química Múltipla/fisiopatologia , Sobrepeso/diagnóstico , Sobrepeso/epidemiologia , Magreza/diagnóstico , Magreza/epidemiologia
11.
Psychiatry Res ; 249: 187-194, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28113122

RESUMO

Idiopathic Environmental Intolerance (IEI) has been associated with psychogenic factors and an increased number of comorbid psychiatric disorders such as depression and anxiety disorder. The purpose of the current study was to examine a possible overlap of psychological and somatic symptoms between subjects with IEI and patients with major depression and schizophrenia as well as to specify characteristic differences. The different symptom clusters included symptoms of chemical intolerance, neurotoxicity and psychological distress as well as measurements of mental health such as anxiety, depression, somatoform symptoms, and schizophrenia-specific disturbances in cognitive domains. IEI patients reported higher overall levels in physical symptoms such as chemical intolerance, neurotoxicity and somatic symptoms not attributable to an organic cause. Schizophrenia patients showed higher overall levels in self-experienced disturbances in several schizophrenia-specific cognitive domains, whereas general psychological distress, anxiety and depression were rated highest by patients with major depression. Importantly, the groups markedly differed in the shapes of profiles of various symptom clusters. Our results provide evidence that IEI patients can be distinguished on the phenomenological level from patients with major depression or schizophrenia, and that distinct domains of psychological and somatic symptoms are particularly problematic in specific diagnostic groups.


Assuntos
Transtorno Depressivo Maior/complicações , Sensibilidade Química Múltipla/complicações , Transtornos Somatoformes/complicações , Adulto , Ansiedade/complicações , Ansiedade/diagnóstico , Ansiedade/psicologia , Depressão/complicações , Depressão/diagnóstico , Depressão/psicologia , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/psicologia , Feminino , Humanos , Masculino , Sintomas Inexplicáveis , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/psicologia , Transtornos Somatoformes/diagnóstico , Transtornos Somatoformes/psicologia , Avaliação de Sintomas
12.
J Occup Environ Med ; 59(1): 80-84, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-28045802

RESUMO

OBJECTIVES: We tested the hypothesis of high comorbidity between asthma/allergy and chemical intolerance (CI) and between asthma/allergy and building intolerance (BI), and high multimorbidity between asthma/allergy, CI, and BI. METHODS: Population-based questionnaire data were used from 530 participants with asthma/allergy (allergic asthma, nonallergic asthma, allergic rhinitis, and/or atopic dermatitis), 414 with self-reported and 112 with physician-diagnosed CI, and 165 with self-reported and 47 with physician-diagnosed BI. Separate reference groups were formed for each of the five case groups. RESULTS: Adjusted odds ratios varied from 4.6 to 13.1 for comorbidity, and from 6.6 to 46.4 for multimorbidity. CONCLUSION: The large comorbidity and multimorbidity between asthma/allergy, CI, and BI evokes the question as to whether there are similarities in underlying mechanisms between these conditions.


Assuntos
Asma/epidemiologia , Dermatite Atópica/epidemiologia , Sensibilidade Química Múltipla/epidemiologia , Rinite Alérgica/epidemiologia , Síndrome do Edifício Doente/epidemiologia , Adulto , Idoso , Comorbidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Síndrome do Edifício Doente/diagnóstico , Inquéritos e Questionários
13.
Int Arch Occup Environ Health ; 89(6): 947-59, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27126704

RESUMO

PURPOSE: Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure. METHODS: An online sample (N = 321) answered established CI questionnaires. Based on the convergent self-reports in these questionnaires, healthy women with generalized CI and healthy female control participants were selected (total N = 26). Baseline characterization was performed using implicit association, lung and olfactory function tests, health-related self-reports, plasma inflammatory and metabolic markers. Performance in neurobehavioral tasks, perceptual ratings, nasal inflammatory, neuroendocrine, and autonomic nervous system reactivity were examined by means of a 75-min whole-body challenge to ammonia (stepwise increase: 0-10 ppm). RESULTS: Correlational analyses confirmed the multidimensionality of CI. Participants with generalized self-reported CI exhibited better olfactory function and reported stronger pungency during the challenge than controls. Cognitive performance and physiological response to the challenge were comparable between the two groups. CONCLUSIONS: Self-reports of CI are complex and not easily assessed by unidimensional questionnaires. While generalized self-reported CI is associated with altered chemosensory processing, it seems unlikely that it modulates health effects and cognitive functioning during chemical exposure.


Assuntos
Amônia/efeitos adversos , Autoavaliação Diagnóstica , Exposição por Inalação/efeitos adversos , Sensibilidade Química Múltipla/fisiopatologia , Limiar Sensorial/efeitos dos fármacos , Adulto , Sistema Nervoso Autônomo/efeitos dos fármacos , Biomarcadores/sangue , Estudos de Casos e Controles , Cognição/efeitos dos fármacos , Feminino , Humanos , Sensibilidade Química Múltipla/diagnóstico , Testes de Função Respiratória , Inquéritos e Questionários
14.
J Vestib Res ; 26(5-6): 459-468, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-28262643

RESUMO

Multiple chemical sensitivity (MCS) is a common clinical diagnosis in western populations and its symptoms are thought to be mainly related to chemical compounds exposure. Although MCS subjects refer to complain from many central nervous system symptoms, including dizziness, no study to now deepened vestibular detriment nor to what extent such an impairment could worsen MCS. Thus, the purpose of present study was to objectively highlight those clinical/subclinical aspects of vestibular impairment that could be related to MCS symptoms cohorts. A principal component analysis within a wide battery of otoneurological test scores was employed in 18 right-handed MCS patients and 20 sex- and age-matched healthy individuals. A deranged dimensionality in near-optimal re-weighting within otoneurological variables was found in MCS as compared with healthy subjects. These data seem to support the idea that MCS physiopathological underpinnings could lead to a peripheral and higher vestibular decay that could be addressed as a further aspect to better follow MCS patients up along natural history of disease in clinical practice.


Assuntos
Sensibilidade Química Múltipla/complicações , Doenças Vestibulares/etiologia , Adulto , Estudos de Coortes , Tontura/etiologia , Feminino , Análise de Fourier , Teste do Impulso da Cabeça , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/fisiopatologia , Exame Neurológico , Análise de Componente Principal , Vertigem/etiologia , Doenças Vestibulares/diagnóstico , Doenças Vestibulares/fisiopatologia , Testes de Função Vestibular
15.
Rev Environ Health ; 30(4): 251-71, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26613326

RESUMO

Much of the controversy over the causes of electro-hypersensitivity (EHS) and multiple chemical sensitivity (MCS) lies in the absence of both recognized clinical criteria and objective biomarkers for widely accepted diagnosis. Since 2009, we have prospectively investigated, clinically and biologically, 1216 consecutive EHS and/or MCS-self reporting cases, in an attempt to answer both questions. We report here our preliminary data, based on 727 evaluable of 839 enrolled cases: 521 (71.6%) were diagnosed with EHS, 52 (7.2%) with MCS, and 154 (21.2%) with both EHS and MCS. Two out of three patients with EHS and/or MCS were female; mean age (years) was 47. As inflammation appears to be a key process resulting from electromagnetic field (EMF) and/or chemical effects on tissues, and histamine release is potentially a major mediator of inflammation, we systematically measured histamine in the blood of patients. Near 40% had a increase in histaminemia (especially when both conditions were present), indicating a chronic inflammatory response can be detected in these patients. Oxidative stress is part of inflammation and is a key contributor to damage and response. Nitrotyrosin, a marker of both peroxynitrite (ONOO°-) production and opening of the blood-brain barrier (BBB), was increased in 28% the cases. Protein S100B, another marker of BBB opening was increased in 15%. Circulating autoantibodies against O-myelin were detected in 23%, indicating EHS and MCS may be associated with autoimmune response. Confirming animal experiments showing the increase of Hsp27 and/or Hsp70 chaperone proteins under the influence of EMF, we found increased Hsp27 and/or Hsp70 in 33% of the patients. As most patients reported chronic insomnia and fatigue, we determined the 24 h urine 6-hydroxymelatonin sulfate (6-OHMS)/creatinin ratio and found it was decreased (<0.8) in all investigated cases. Finally, considering the self-reported symptoms of EHS and MCS, we serially measured the brain blood flow (BBF) in the temporal lobes of each case with pulsed cerebral ultrasound computed tomosphygmography. Both disorders were associated with hypoperfusion in the capsulothalamic area, suggesting that the inflammatory process involve the limbic system and the thalamus. Our data strongly suggest that EHS and MCS can be objectively characterized and routinely diagnosed by commercially available simple tests. Both disorders appear to involve inflammation-related hyper-histaminemia, oxidative stress, autoimmune response, capsulothalamic hypoperfusion and BBB opening, and a deficit in melatonin metabolic availability; suggesting a risk of chronic neurodegenerative disease. Finally the common co-occurrence of EHS and MCS strongly suggests a common pathological mechanism.


Assuntos
Biomarcadores/metabolismo , Hipersensibilidade/diagnóstico , Inflamação/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Biomarcadores/urina , Campos Eletromagnéticos/efeitos adversos , Feminino , Humanos , Hipersensibilidade/etiologia , Inflamação/etiologia , Masculino , Pessoa de Meia-Idade , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/etiologia , Ondas de Rádio/efeitos adversos , Adulto Jovem
17.
Expert Rev Clin Immunol ; 11(9): 973-6, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26144241

RESUMO

A panel of Italian allergists gathered to discuss the issue concerning the management of polysensitized patients. The main conclusions were as follows: polysensitization is a relevant clinical characteristic as it affects about 70-80% of the global allergic population; the diagnostic pathway needs the use of an adequate and thorough methodology, based on the demonstration of consistency between history and documented sensitization; polysensitization and polyallergy are not synonymous: true allergy should always be demonstrated; polysensitization does not constitute a limitation to allergen immunotherapy prescription, as 1-2 allergen extracts could be effective in polysensitized patients; the allergen immunotherapy product characteristics should include the following: high efficacy and optimal safety profile, standardized production, and documented presence and titration of the major allergen.


Assuntos
Alérgenos/imunologia , Dessensibilização Imunológica/métodos , Sensibilidade Química Múltipla/imunologia , Sensibilidade Química Múltipla/terapia , Diagnóstico Diferencial , Humanos , Hipersensibilidade/diagnóstico , Hipersensibilidade/imunologia , Hipersensibilidade/terapia , Sensibilidade Química Múltipla/diagnóstico , Qualidade de Vida , Resultado do Tratamento
18.
J Am Board Fam Med ; 28(4): 461-70, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26152436

RESUMO

PURPOSE: The aim of this study was to assess whether chemically intolerant women are at greater risk for having a child with autism spectrum disorders (ASD) or attention deficit hyperactivity disorder (ADHD). METHODS: We conducted a case-control study of chemical intolerance among mothers of children with ASD (n = 282) or ADHD (n = 258) and children without these disorders (n = 154). Mothers participated in an online survey consisting of a validated chemical intolerance screening instrument, the Quick Environmental Exposure and Sensitivity Inventory (QEESI). Cases and controls were characterized by parental report of a professional diagnosis. We used a one-way, unbalanced analysis of variance to compare means across the 3 groups. RESULTS: Both mothers of children with ASD or ADHD had significantly higher mean chemical intolerance scores than did mothers of controls, and they were more likely to report adverse reactions to drugs. Chemically intolerant mothers were 3 times more likely (odds ratio, 3.01; 95% confidence interval, 1.50-6.02) to report having a child with autism or 2.3 times more likely (odds ratio, 2.3; 95% confidence interval, 1.12-5.04) to report a child with ADHD. Relative to controls, these mothers report their children are more prone to allergies (P < .02), have strong food preferences or cravings (P < .003), and have greater sensitivity to noxious odors (P < .04). CONCLUSION: These findings suggest a potential association between maternal chemical intolerance and a diagnosis of ADHD or ASD in their offspring.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/etiologia , Transtorno Autístico/etiologia , Hipersensibilidade a Drogas/diagnóstico , Mães , Sensibilidade Química Múltipla/diagnóstico , Adolescente , Adulto , Estudos de Casos e Controles , Criança , Estudos Transversais , Feminino , Interação Gene-Ambiente , Inquéritos Epidemiológicos , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Fatores de Risco , Adulto Jovem
19.
Curr Rheumatol Rev ; 11(2): 167-84, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26088215

RESUMO

Chemical intolerance (CI) is a term used to describe a condition in which the sufferer experiences a complex array of recurrent unspecific symptoms attributed to low-level chemical exposure that most people regard as unproblematic. Severe CI constitutes the distinguishing feature of multiple chemical sensitivity (MCS). The symptoms reported by CI subjects are manifold, involving symptoms from multiple organs systems. In severe cases of CI, the condition can cause considerable life-style limitations with severe social, occupational and economic consequences. As no diagnostic tools for CI are available, the presence of the condition can only be established in accordance to criteria definitions. Numerous modes of action have been suggested to explain CI, with the most commonly discussed theories involving the immune system, central nervous system, olfactory and respiratory systems as well as altered metabolic capacity, behavioral conditioning and emotional regulation. However, in spite of more than 50 years of research, there is still a great deal of uncertainties regarding the event(s) and underlying mechanism( s) behind symptom elicitation. As a result, patients are often misdiagnosed or offered health care solutions with limited or no effect, and they experience being met with mistrust and doubt by health care professionals, the social care system and by friends and relatives. Evidence-based treatment options are currently unavailable, however, a person-centered care model based on a multidisciplinary treatment approach and individualized care plans have shown promising results. With this in mind, further research studies and health care solutions should be based on a multifactorial and interdisciplinary approach.


Assuntos
Sensibilidade Química Múltipla , Humanos , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/fisiopatologia , Sensibilidade Química Múltipla/terapia , Fatores de Risco
20.
Int J Behav Med ; 22(6): 755-63, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25778471

RESUMO

BACKGROUND: Among people with idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF), a better than random detection ability for a 50-Hz 0.5-mT magnetic field (MF) and a propensity to experience more symptoms than controls was reported in a previous study. PURPOSE: The current study aimed to replicate and clarify these results using a modified experimental design. METHOD: Participants of the provocation experiment were 49 individuals with self-reported IEI-EMF and 57 controls. They completed the questionnaires (symptom expectations, Somatosensory Amplification Scale--SSAS, radiation subscale of the Modern Health Worries Scale--MHWS Radiation) and attempted to detect the presence of the MF directed to their right arm in 20 subsequent 1-min sessions. Symptom reports were registered after each session. RESULTS: Individuals with IEI-EMF as opposed to the control group showed a higher than random detection performance (d' index of signal detection theory), while no difference in their bias (ß index) toward the presence of the MF was found. Predictors of reported symptoms were self-reported IEI-EMF and believed as opposed to actual presence of the MF. People with IEI-EMF reported significantly more symptoms particularly in the believed presence of the MF. IEI-EMF was closely related to MHWS Radiation and SSAS scores. CONCLUSION: People with IEI-EMF might be able to detect the presence of the MF to a small extent; however, their symptom reports are connected to perceived exposure.


Assuntos
Campos Eletromagnéticos/efeitos adversos , Sensibilidade Química Múltipla , Adulto , Ansiedade/fisiopatologia , Exposição Ambiental/efeitos adversos , Feminino , Área de Dependência-Independência , Humanos , Masculino , Sensibilidade Química Múltipla/diagnóstico , Sensibilidade Química Múltipla/etiologia , Sensibilidade Química Múltipla/psicologia , Autorrelato , Inquéritos e Questionários
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