Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 460
Filtrar
1.
Rev Bras Epidemiol ; 22: e190009, 2019 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-30892472

RESUMO

INTRODUCTION: The written information on medicines has been acknowledged as an important tool for health education. OBJECTIVE: To analyze the use and understanding of medicine package inserts by users and assess sociodemographic and medical factors associated with their comprehension. METHOD: Data in this analysis are part of the PNAUM National Survey - a cross-sectional population-based study conducted in Brazil. Descriptive statistics and the Pearson χ2 tests were performed to compare proportions between sociodemographic and medical characteristics, as well as use and understanding of medicine package inserts. RESULTS: A total of 28.427 individuals responded to questions related to medicine package inserts. From these, 59.6% (95%CI 57.7 - 61.5) said they usually read the inserts, and 98.4% (95%CI 98.0 - 98.8) considered them necessary. Among people who read the medicine package inserts, more than half indicated difficulties with legibility (57.4%; 95%CI 55,2 - 59,6) and readability (54.1%; 95%CI 52.1 - 56.1). People from a lower education level reported greater difficulty in understanding them. CONCLUSION: The larger portion of the population usually read medicine package inserts. Nevertheless, people have difficulty in reading and understanding them.


Assuntos
Compreensão , Serviços de Informação sobre Medicamentos/normas , Rotulagem de Produtos , Adolescente , Adulto , Brasil , Estudos Transversais , Escolaridade , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Alfabetização em Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
2.
Cad Saude Publica ; 35(2): e00041018, 2019 02 18.
Artigo em Português | MEDLINE | ID: mdl-30785486

RESUMO

This article sought to evaluate the conformity between recommendations regarding antidepressant use during breastfeeding found in drug package inserts with recommendations from science-based bibliographic sources. We evaluated the standard drug package inserts of 23 antidepressants with active registration in Brazil. The presence of contraindications of antidepressant use during breastfeeding was compared with information present in the Brazilian Ministry of Health technical manual, the book Medications and Mothers' Milk and on the databases LactMed, Micromedex and UpToDate. In most drug package inserts (62.5%), antidepressants are contraindicated during breastfeeding. Among bibliographical sources, that percentage varied between 0% and 25%. The study shows a low conformity between drug package inserts and bibliographical sources, alerting to the need for revising the content and presentation of information present in antidepressant drug package inserts in Brazil.


Assuntos
Antidepressivos/efeitos adversos , Aleitamento Materno/efeitos adversos , Indústria Farmacêutica/normas , Rotulagem de Medicamentos/normas , Medicina Baseada em Evidências , Antidepressivos/administração & dosagem , Brasil , Serviços de Informação sobre Medicamentos/normas , Monitoramento de Medicamentos , Feminino , Humanos , Lactação/metabolismo , Exposição Materna/efeitos adversos , Fatores de Risco
3.
J Med Libr Assoc ; 107(1): 62-71, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30598650

RESUMO

Objective: The research evaluated point-of-care drug interaction resources for scope, completeness, and consistency in drug-ethanol and drug-tobacco content. Methods: In a cross-sectional analysis, 2 independent reviewers extracted data for 108 clinically relevant interactions using 7 drug information resources (Clinical Pharmacology Drug Interaction Report, Facts & Comparisons eAnswers, Lexicomp Interactions, Micromedex Drug Interactions, Drug Interactions Analysis and Management, Drug Interaction Facts, and Stockley's Drug Interactions). Scope (presence of an entry), completeness (content describing mechanism, clinical effects, severity, level of certainty, and course of action for each present interaction; up to 1 point per assessed item for a total possible score of 5 points), and consistency (similarity among resources) were evaluated. Results: Fifty-three drug-ethanol and 55 drug-tobacco interactions were analyzed. Drug-ethanol interaction entries were most commonly present in Lexicomp (84.9%), Clinical Pharmacology (83.0%), and Stockley's Drug Interactions (73.6%), compared to other resources (p<0.05). Drug-tobacco interactions were more often covered in Micromedex (56.4%), Stockley's Drug Interactions (56.4%), Drug Interaction Facts (43.6%), and Clinical Pharmacology (41.8%) (p<0.001). Overall completeness scores were higher for Lexicomp, Micromedex, Drug Interaction Facts, and Facts & Comparisons (median 5/5 points, interquartile range [IQR] 5 to 5, p<0.001) for drug-ethanol and for Micromedex (median 5/5 points, IQR 5 to 5, p<0.05) for drug-tobacco, compared to other resources. Drug Interaction Facts and Micromedex were among the highest scoring resources for both drug-ethanol (73.7%, 68.6%) and drug-tobacco (75.0%, 32.3%) consistency. Conclusions: Scope and completeness were high for drug-ethanol interactions, but low for drug-tobacco interactions. Consistency was highly variable across both interaction types.


Assuntos
Bases de Dados Factuais/normas , Serviços de Informação sobre Medicamentos/normas , Interações de Medicamentos , Etanol/efeitos adversos , Tabaco/efeitos adversos , Estudos Transversais , Humanos
4.
Int J Pharm Pract ; 27(3): 322-324, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30604466

RESUMO

OBJECTIVE: Identify drug information (DI) resources used in neonatal practice guidelines in low- and middle-income countries. METHODS: Individuals with knowledge of national neonatal guideline development completed a descriptive, cross-sectional survey. KEY FINDINGS: Eighty-five per cent (33/39) of respondents fully completed the survey. Physicians from university hospitals in Africa were primary respondents. Forty-five per cent (15/33) used a single national neonatal guideline. Primary neonatal resources for drug dosing and preparation were as follows: (1) World Health Organization Pocketbook of Hospital Care for Children, (2) Pediatric & Neonatal Dosage Handbook and (3) National Institute for Health and Care Excellence for Infants and Neonatal pathways. CONCLUSION: Low- and middle-income countries with single national neonatal guidelines cite a finite range of DI resources.


Assuntos
Serviços de Informação sobre Medicamentos/normas , Neonatologia/normas , Guias de Prática Clínica como Assunto , Estudos Transversais , Países em Desenvolvimento , Pessoal de Saúde/estatística & dados numéricos , Humanos , Inquéritos e Questionários/estatística & dados numéricos
5.
Inform Health Soc Care ; 44(2): 152-163, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-29504838

RESUMO

BACKGROUND: The use of a nationwide medication plan has been promoted as an effective strategy to improve patient safety in Germany. However, the medication plan only exists as a paper-based version, which is related to several problems, that could be circumvented by an electronic alternative. OBJECTIVE: The main objective of this study was to report on the development of a mobile interface concept to support the management of medication information. METHODS: The human-centered design (UCD) process was chosen. First the context of use was analyzed, and personas and an interaction concept were designed. Next, a paper prototype was developed and evaluated by experts. Based on those results, a medium-fidelity prototype was created and assessed by seven end-users who performed a thinking-aloud test in combination with a questionnaire based on the System Usability Scale (SUS). RESULTS: Initially for one persona/user type, an interface design concept was developed, which received an average SUS-Score of 92.1 in the user test. Usability problems have been solved so that the design concept could be fixed for a future implementation. Contribution: The approach of the UCD process and the methods involved can be applied by other researchers as a framework for the development of similar applications.


Assuntos
Serviços de Informação sobre Medicamentos/normas , Aplicativos Móveis/normas , Desenho de Programas de Computador , Interface Usuário-Computador , Fatores Etários , Alemanha , Humanos , Adesão à Medicação , Fatores Sexuais , Fatores Socioeconômicos
6.
J Oncol Pharm Pract ; 25(1): 60-67, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28841101

RESUMO

BACKGROUND: This study was conducted to explore the role of clinical pharmacists in providing medicine and therapeutic information service in oncology care setting. METHODS: It was a prospective study conducted for a period of three years after implementation of medicine and therapeutic information service as an integral part of oncology pharmacy services. The medicine and therapeutic information queries were received during ward rounds, at ambulatory care and via telephone by clinical pharmacists. All the medicine and therapeutic information requests were reviewed and answered to the concerned requester(s). Answered medicine and therapeutic information requests were electronically documented in the hospital drug information database and analyzed further. RESULTS: A total of 484 medicine and therapeutic information requests were received by clinical pharmacists during period of August 2013 to June 2016. Majority of medicine and therapeutic information queries were requested by radiation oncologists (27.2%) followed by medical oncologists (26.4%), general physicians (14.04%), resident medical officers (11.7%), ambulatory care nurses (8.6%), in-patient nurses (5.1%) and patients and care takers (6.6%). Majority of the medicine and therapeutic information queries were asked for the purpose of improving patient care (48.3%) followed by to update knowledge (30.9%) and training sessions to nurses (6.6%). The most common categories of medicine and therapeutic information were adverse drug reactions and its management (21.4%) followed by dosage adjustments of chemotherapy and biologicals (15.5%), supportive care related (14.6%), contraindications (14%), drug-drug interactions (11.9%), management of co-morbidities (7.8%), chemotherapy selection in special populations (4.5%). CONCLUSION: The provision of medicine and therapeutic information was found to be useful in providing medicine information to improve patient care and to update knowledge of health care professionals at the study hospital.


Assuntos
Serviços de Informação sobre Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Disseminação de Informação/métodos , Oncologia/métodos , Serviço de Farmácia Hospitalar , Serviços de Informação sobre Medicamentos/organização & administração , Serviços de Informação sobre Medicamentos/normas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/diagnóstico , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/terapia , Humanos , Índia , Farmacêuticos/normas , Serviço de Farmácia Hospitalar/organização & administração , Serviço de Farmácia Hospitalar/normas , Estudos Prospectivos , Melhoria de Qualidade
7.
Curr Pharm Teach Learn ; 10(12): 1587-1593, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30527824

RESUMO

BACKGROUND AND PURPOSE: Drug interaction management is essential in pharmacy practice. The purpose of this study was to evaluate student pharmacists' ability and confidence using drug information databases to investigate a drug-drug interaction previously unencountered in the curriculum. EDUCATIONAL ACTIVITY AND SETTING: A cross-sectional study was conducted where didactic students were presented with three cases, each containing an interaction. Students were asked to select a drug information resource and determine the mechanism, clinical effects, severity, level of documentation, and course of action for each interaction. Overall performance was assessed on a 15-point scale (one point for each assessment item for each interaction), and students were asked to rate their confidence on a five-point scale for each interaction, yielding a 15-point confidence scale. FINDINGS: For the 187 participants (90.8% response rate) who completed each interaction assessment, overall median performance score was 14 out of 15 possible points (IQR 12-15); 58 (31.0%) earned the maximum score of 15 points. Median confidence score was 13 out of 15 possible points (IQR 12-14). DISCUSSION: This study uniquely assessed students' competency in interactions by focusing on analysis, as opposed to recall of basic facts. Although most students performed well, a significant minority earned an overall performance score of 80% or less, suggesting need for continued practice and improvement. SUMMARY: This cross-section of student pharmacists earned generally high performance scores when assessed on their ability to use a drug information resource to analyze interactions, and were mostly highly confident.


Assuntos
Serviços de Informação sobre Medicamentos/normas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/fisiopatologia , Estudantes de Farmácia/psicologia , Adulto , Estudos Transversais , Interações de Medicamentos , Educação em Farmácia/métodos , Avaliação Educacional/métodos , Feminino , Humanos , Masculino , Estudantes de Farmácia/estatística & dados numéricos , Inquéritos e Questionários
8.
J Med Libr Assoc ; 106(3): 352-360, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29962913

RESUMO

Objectives: The research compared the comprehensiveness and accuracy of two online resources that provide drug information: Lexicomp and Wikipedia. Methods: Medication information on five commonly prescribed medications was identified and comparisons were made between resources and the relevant literature. An initial content comparison of the following three categories of medication information was performed: dose and instructions, uses, and adverse effects or warnings. The content comparison included sixteen points of comparison for each of the five investigated medications, totaling eighty content comparisons. For each of the medications, adverse reactions that appeared in only one of the resources were identified. When primary, peer-reviewed literature was not referenced supporting the discrepant adverse reactions, a literature search was performed to determine whether or not evidence existed to support the listed claims. Results: Lexicomp consistently provided more medication information, with information provided in 95.0% (76/80) of the content, compared to Wikipedia's 42.5% (34/80). Lexicomp and Wikipedia had information present in 91.4% (32/35) and 20.0% (7/35) of dosing and instructions content, respectively. Adverse effects or warning content was provided in 97.5% (39/40) of Lexicomp content and 55.0% (22/40) of Wikipedia content. The "uses" category was present in both Lexicomp and Wikipedia for the 5 medications considered. Of adverse reactions listed solely in Lexicomp, 191/302 (63.2%) were supported by primary, peer-reviewed literature in contrast to 7/7 (100.0%) of adverse reactions listed only in Wikipedia. A review of US Food and Drug Administration Prescribing Information and the Adverse Event Reporting System dashboard found support for a respective 17/102 (16.7%) and 92/102 (90.2%) of Lexicomp's adverse reactions that were not supported in the literature. Conclusion: Lexicomp is a comprehensive medication information tool that contains lists of adverse reactions that are not entirely supported by primary-peer reviewed literature.


Assuntos
Informação de Saúde ao Consumidor/normas , Serviços de Informação sobre Medicamentos/normas , Internet , Medicamentos sob Prescrição , Humanos
9.
Int J Med Inform ; 114: 27-34, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29673600

RESUMO

INTRODUCTION: In view of the popularity of Internet usage in Hong Kong, an interactive web-based drug information platform entitled "Ask My Pharmacist - Online University Led drug Enquiry Platform" (AMPOULE) was launched in 2009 to better serve the needs of drug information in Hong Kong. This paper aimed to evaluate the utility of AMPOULE in improving drug-related knowledge among the public and to reassess the needs of the general public in Hong Kong. METHODS: All enquiries sent via AMPOULE were reviewed. Demographic data, nature of questions and types of drug class covered were analyzed. The workload of pharmacists was examined with respect to the preparation time needed for the enquiry, the lag days to reply and also the timing of enquiry recipient. RESULTS: 2122 enquiries were received from 2009 to 2017. Most enquirers were from Hong Kong (56.6%) and female gender (49.2%). 13% of the concerned subjects were aged over 61-year-old. The most frequent types of questions and medications covered were "Drug Ingredients and Indications" (28.0%) and Adverse Drug Reactions (26.8%) and "Cardiovascular Medication" (21.9%) respectively but these varied in different age groups or enquirer groups. The median time for preparation was 40.0 min (IQR: 25-65 min) while the median time lag was found to be 2.5 days (IQR: 1.0-5.0 days). The number of enquiries received was evenly distributed throughout the day except during 1:00 am to 9:00 am and 7:00 pm to 8:00 pm. CONCLUSION: AMPOULE has demonstrated that an online platform providing patient-oriented drug information service through the Internet is promising and further promotion is warranted. Current data suggested that the need of different age groups and enquirer groups are different and should therefore be individualized.


Assuntos
Serviços de Informação sobre Medicamentos/normas , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Determinação de Necessidades de Cuidados de Saúde , Sistemas On-Line , Farmacêuticos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Hong Kong , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Adulto Jovem
11.
Biomed Res Int ; 2017: 8310636, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28951876

RESUMO

BACKGROUND: Community pharmacists are in a key position to provide information on drugs and thus promote the rational use of drugs. OBJECTIVES: The present study was designed to determine the needs and resources of drug information in community pharmacies. METHODS: A prospective institution based cross-sectional study was carried out and data were collected on 48 community pharmacists in Gondar, Northwest Ethiopia, using interviewer administered structured questionnaire. RESULTS: Almost all pharmacists (N = 47, 97.9%) often receive drug related queries and these were mainly from consumers (N = 41, 85.4%). While most questions relate to drug price (N = 29, 60.4%) and dosage (N = 21, 43.8%), the information resources mainly referred to were drug package inserts and national standard treatment guidelines. However, limited availability of information resources as well as limited ability to retrieve relevant information influenced the practice of pharmacists. Female pharmacists claimed better use of different information resources than males (P < 0.05). CONCLUSIONS: Community pharmacists in Gondar, Northwest Ethiopia, are often accessed for drug related information. But there are limitations in using up to date and most reliable resources. Therefore, intervention aimed at improving pharmacists' access to and evaluation of drug information is urgently needed.


Assuntos
Serviços de Informação sobre Medicamentos/estatística & dados numéricos , Serviços de Informação sobre Medicamentos/normas , Farmácias/estatística & dados numéricos , Adulto , Estudos Transversais , Rotulagem de Medicamentos/normas , Rotulagem de Medicamentos/estatística & dados numéricos , Etiópia , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Farmacêuticos/estatística & dados numéricos , Estudos Prospectivos , Inquéritos e Questionários , Adulto Jovem
12.
J Am Pharm Assoc (2003) ; 57(6): 698-703.e2, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28844584

RESUMO

BACKGROUND: With an increasing prevalence of psychotropic polypharmacy, clinicians depend on drug-drug interaction (DDI) references to ensure safe regimens, but the consistency of such information is frequently questioned. OBJECTIVES: To evaluate the consistency of psychotropic DDIs documented in Clinical Pharmacology (CP), Micromedex (MM), and Lexicomp (LC) and summarize consistent psychotropic DDIs. METHODS: In May 2016, we extracted severe or major psychotropic DDIs for 102 psychotropic drugs, including central nervous system (CNS) stimulants, antidepressants, an antimanic agent (lithium), antipsychotics, anticonvulsants, and anxiolytics-sedatives-hypnotics from CP, MM, and LC. We then summarized the psychotropic DDIs that were included in all 3 references and with evidence quality of "excellent" or "good" based on MM. RESULTS: We identified 1496, 938, and 1006 unique severe or major psychotropic DDIs from CP, MM, and LC, respectively. Common adverse effects related to psychotropic DDIs include increased or decreased effectiveness, CNS depression, neurotoxicity, QT prolongation, serotonin syndrome, and multiple adverse effects. Among these interactions, only 371 psychotropic DDIs were documented in all 3 references, 59 of which had "excellent" or "good" quality of evidence based on MM. CONCLUSION: The consistency of psychotropic DDI documentation across CP, MM, and LC is poor. DDI documentations need standards that would encourage consistency among drug information references. The list of the 59 DDIs may be useful in the assessment of psychotropic polypharmacy and highlighting DDI alerts in clinical practice.


Assuntos
Acesso à Informação , Serviços de Informação sobre Medicamentos/normas , Interações de Medicamentos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Psicotrópicos/efeitos adversos , Quimioterapia Combinada , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Humanos , Polimedicação , Medição de Risco , Fatores de Risco
13.
Farm Hosp ; 41(3): 334-345, 2017 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-28478748

RESUMO

OBJECTIVE: To define the activities of the Drug Information Centre of the Federal Council of Pharmacy (Cebrim/FCP), to describe the passive information and the satisfaction of its users. METHOD: The centre has a computerized system for recording and storing the received questions and their answers: the Sistema de Informação Farmacoterapêutica SIFAR (Pharmacotherapeutical Information System) that generates management reports; out of these, the reports from the period 2010 to 2015 were analyzed. RESULTS: The main activity carried out by the centre was the passive information provided to pharmacists and undergraduate Pharmacy students. The most frequent subjects were: administration and way of use of medicines and indication and drug interactions, which were answered in less than 24 hours in most cases. Approximately 80% of those users who completed the satisfaction survey rated the service provided as good and optimal. CONCLUSION: Cebrim/FCP provides objective, updated and timely information (passive information) on medicines for pharmacists, with administration and way of use as the most recurrent subjects, and the majority of applicants were satisfied with the service.


Assuntos
Serviços de Informação sobre Medicamentos/normas , Brasil , Comportamento do Consumidor , Humanos , Gestão da Informação , Conduta do Tratamento Medicamentoso , Farmacêuticos , Serviço de Farmácia Hospitalar
14.
Pharm. pract. (Granada, Internet) ; 15(1): 0-0, ene.-mar. 2017. tab
Artigo em Inglês | IBECS | ID: ibc-161869

RESUMO

Objective: To determine which drug references Utah pharmacists use most frequently. To determine which types of drug information questions are most commonly asked, and whether Utah pharmacists have access to adequate references to respond to these questions. Methods: A 19-question survey was created using Qualtrics, LLC (Provo, Utah) software. An electronic survey link was sent to 1,431 pharmacists with a valid e-mail address listed in the Department of Professional Licensing database. Questions focused on available references in the participant’s pharmacy, how current the references are, and the participant’s use of the references. Surveys were analyzed for participants practicing in either community or hospital pharmacies in the state of Utah. Results: A total of 147 responses were included in the analysis. Approximately 44% of respondents practiced in the community, and 56% practiced in a hospital setting. The most commonly used references by Utah pharmacists are Micromedex, Lexicomp, UpToDate, Clinical Pharmacology, and Drug Facts & Comparisons. Pharmacists in the community frequently receive questions related to adverse drug reactions, drug interactions, and over-the-counter medications. Pharmacists in the hospital frequently receive questions relating to dosage and administration, drug interactions, and adverse drug reactions. About 89% of community pharmacists and 96% of hospital pharmacists feel available references are adequate to answer the questions they receive. Conclusions: Utah pharmacists generally use large reference suites to answer drug information questions. The majority of pharmacists consider the references available to them to be adequate to answer the questions they receive (AU)


No disponible


Assuntos
Humanos , Masculino , Feminino , Avaliação de Medicamentos/métodos , Medicamentos de Referência , Farmácias/organização & administração , Serviços de Informação sobre Medicamentos/organização & administração , Farmacêuticos/organização & administração , Farmacoepidemiologia/métodos , Utah/epidemiologia , Assistência Farmacêutica/normas , Farmacêuticos/normas , Avaliação de Medicamentos/tendências , Inquéritos e Questionários , Serviços de Informação sobre Medicamentos/normas , Prática Profissional/normas , Análise Estatística
15.
BMC Med Inform Decis Mak ; 17(1): 21, 2017 02 22.
Artigo em Inglês | MEDLINE | ID: mdl-28228132

RESUMO

BACKGROUND: Drug information compendia and drug-drug interaction information databases are critical resources for clinicians and pharmacists working to avoid adverse events due to exposure to potential drug-drug interactions (PDDIs). Our goal is to develop information models, annotated data, and search tools that will facilitate the interpretation of PDDI information. To better understand the information needs and work practices of specialists who search and synthesize PDDI evidence for drug information resources, we conducted an inquiry that combined a thematic analysis of published literature with unstructured interviews. METHODS: Starting from an initial set of relevant articles, we developed search terms and conducted a literature search. Two reviewers conducted a thematic analysis of included articles. Unstructured interviews with drug information experts were conducted and similarly coded. Information needs, work processes, and indicators of potential strengths and weaknesses of information systems were identified. RESULTS: Review of 92 papers and 10 interviews identified 56 categories of information needs related to the interpretation of PDDI information including drug and interaction information; study design; evidence including clinical details, quality and content of reports, and consequences; and potential recommendations. We also identified strengths/weaknesses of PDDI information systems. CONCLUSIONS: We identified the kinds of information that might be most effective for summarizing PDDIs. The drug information experts we interviewed had differing goals, suggesting a need for detailed information models and flexible presentations. Several information needs not discussed in previous work were identified, including temporal overlaps in drug administration, biological plausibility of interactions, and assessment of the quality and content of reports. Richly structured depictions of PDDI information may help drug information experts more effectively interpret data and develop recommendations. Effective information models and system designs will be needed to maximize the utility of this information.


Assuntos
Sistemas de Apoio a Decisões Clínicas/normas , Serviços de Informação sobre Medicamentos/normas , Interações de Medicamentos , Guias de Prática Clínica como Assunto/normas , Humanos
16.
J Am Pharm Assoc (2003) ; 57(2): 193-196.e1, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27866956

RESUMO

OBJECTIVES: The primary objective of this study was to determine the accuracy and completeness of drug information on Wikipedia and Micromedex compared with U.S. Food and Drug Administration-approved U.S. product inserts. METHODS: The top 10 brand and top 10 generic medications from the 2012 Institute for Health Informatics' list of top 200 drugs were selected for evaluation. Wikipedia medication information was evaluated and compared with Micromedex in 7 sections of drug information; the U.S. product inserts were used as the standard comparator. RESULTS: Wikipedia demonstrated significantly lower completeness and accuracy scores compared with Micromedex (mean composite scores 18.55 vs. 38.4, respectively; P <0.01). No difference was found between the mean composite scores for brand versus generic drugs in either reference (17.8 vs. 19.3, respectively [P = 0.62], for Wikipedia; 39.2 vs. 37.6, [P = 0.06] for Micromedex). Limitations to these results include the speed with which information is edited on Wikipedia, that there was no evaluation of off-label information, and the limited number of drugs that were evaluated. CONCLUSION: Wikipedia lacks the accuracy and completeness of standard clinical references and should not be a routine part of clinical decision making. More research should be conducted to evaluate the rationale for health care providers' use of Wikipedia.


Assuntos
Informação de Saúde ao Consumidor/normas , Serviços de Informação sobre Medicamentos/normas , Disseminação de Informação/métodos , Internet/normas , Tomada de Decisão Clínica , Rotulagem de Medicamentos , Humanos , Reprodutibilidade dos Testes , Estados Unidos , United States Food and Drug Administration
17.
J Med Libr Assoc ; 104(4): 290-295, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27822150

RESUMO

OBJECTIVE: The research sought to evaluate seven drug information resources, specifically designed for analyzing drug interactions for scope, completeness, and ease of use, and determine the consistency of content among the seven resources. METHODS: A cross-sectional study was conducted where 100 drug-drug and drug-dietary supplement interactions were analyzed using 7 drug information resources: Lexicomp Interactions module, Micromedex Drug Interactions, Clinical Pharmacology Drug Interaction Report, Facts & Comparisons eAnswers, Stockley's Drug Interactions (10th edition), Drug Interactions Analysis and Management (2014), and Drug Interaction Facts (2015). The interaction sample was developed based on published resources and peer input. Two independent reviewers gathered data for each interaction from each of the 7 resources using a common form. RESULTS: Eighty-two drug-drug and 18 drug-dietary supplement interactions were analyzed. Scope scores were higher for Lexicomp Interactions (97.0%), Clinical Pharmacology Drug Interaction Report (97.0%), and Micromedex Drug Interactions (93.0%) compared to all other resources (p<0.05 for each comparison). Overall completeness scores were higher for Micromedex Drug Interactions (median 5, interquartile range [IQR] 4 to 5) compared to all other resources (p<0.01 for each comparison) and were higher for Lexicomp Interactions (median 4, IQR 4 to 5), Facts & Comparisons eAnswers (median 4, IQR 4 to 5), and Drug Interaction Facts (4, IQR 4 to 5) compared to all other resources, except Micromedex (p<0.05 for each comparison). Ease of use, in terms of time to locate information and time to gather information, was similar among resources. Consistency score was higher for Micromedex (69.9%) compared to all other resources (p<0.05 for each comparison). CONCLUSIONS: Clinical Pharmacology Drug Interaction Report, Lexicomp Interactions, and Micromedex Drug Interactions scored highest in scope. Micromedex Drug Interactions and Lexicomp Interactions scored highest in completeness. Consistency scores were overall low, but Micromedex Drug Interactions was the highest.


Assuntos
Serviços de Informação sobre Medicamentos , Interações de Medicamentos , Bases de Dados Factuais/normas , Serviços de Informação sobre Medicamentos/normas , Humanos , Obras de Referência/normas
19.
J Opioid Manag ; 12(4): 281-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27575829

RESUMO

BACKGROUND: Healthcare professionals and consumers refer to online drug-information compendia (eg, Epocrates and WebMD) to learn about prescription medications, including opioid analgesics. With the significant risks associated with opioids, including abuse, misuse, and addiction, any of which can result in life-threatening overdose, it is important for those seeking information from online compendia to have access to current, accurate, and complete drug information to help support clinical treatment decisions. Although compendia are informative, readily available, and user friendly, studies have shown that they may contain errors. OBJECTIVE: To review and identify misinformation in drug summaries of online drug-information compendia for selected opioid analgesic products and submit content corrections to the respective editors. METHODS: Between 2011 and 2013, drug summaries for Purdue's prescription opioid analgesic products from seven leading online drug-information compendia were systematically reviewed, and the requests for corrections were retrospectively categorized and classified. At least 2 months following requests, the same compendia were then reexamined to assess the degree of error resolution. RESULTS: A total of 859 errors were identified, with the greatest percentage in Safety and Patient Education categories. Across the seven compendia, the complete or partial resolution of errors was 34 percent; therefore, nearly two thirds of the identified errors remain. CONCLUSION: The results of this analysis, consistent with past studies, demonstrate that online drug-information compendia may contain inaccurate information. Healthcare professionals and consumers must be informed of potential misinformation so they may consider using multiple resources to obtain accurate and current drug information, thereby helping to ensure safer use of prescription medications, such as opioids.


Assuntos
Analgésicos Opioides/efeitos adversos , Qualidade de Produtos para o Consumidor/normas , Serviços de Informação sobre Medicamentos/normas , Educação de Pacientes como Assunto , Farmacopeias como Assunto/normas , Medicamentos sob Prescrição/efeitos adversos , Bases de Dados Factuais , Internet
20.
J Med Libr Assoc ; 104(1): 58-61, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26807054

RESUMO

BACKGROUND: Pharmacogenomics is the study of how genes affect a person's response to drugs. This descriptive study assessed whether popular drug information resources provide clinically useful pharmacogenomic (PGx) information. METHODS: Four resources (package inserts, Lexicomp, Micromedex 2.0, and Epocrates) were evaluated for information about twenty-seven drugs. RESULTS: There was wide variability of PGx information. Whereas Lexicomp included relevant PGx biomarker information for all 27 drugs, Epocrates did in less than 50% of the drugs. None of the resources had monographs that fully incorporated Clinical Pharmacogenomics Implementation Consortium (CPIC) recommendations in more than 30% of the drugs. CONCLUSION: Lexicomp appears to be most useful PGx drug information resource, but none of the resources are sufficient.


Assuntos
Bases de Dados como Assunto , Bases de Dados Factuais/normas , Serviços de Informação sobre Medicamentos/normas , Farmacogenética/educação , Humanos , Sensibilidade e Especificidade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA