Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 914
Filtrar
1.
Artigo em Inglês | MEDLINE | ID: mdl-34769551

RESUMO

Artisanal and small-scale miners (ASMs) labour under archaic working conditions and are exposed to high levels of silica dust. Exposure to silica dust has been associated with an increased risk of tuberculosis and silicosis. ASMs are highly mobile and operate in remote areas with near absent access to health services. The main purpose of this study was to evaluate the prevalence of tuberculosis, silicosis and silico-tuberculosis among ASMs in Zimbabwe. A cross-sectional study was conducted from 1 October to 31 January 2021 on a convenient sample of 514 self-selected ASMs. We report the results from among those ASMs who attended an outreach medical facility and an occupational health clinic. Data were collected from clinical records using a precoded data proforma. Data variables included demographic (age, sex), clinical details (HIV status, GeneXpert results, outcomes of chest radiographs, history of tuberculosis) and perceived exposure to mine dust. Of the 464 miners screened for silicosis, 52 (11.2%) were diagnosed with silicosis, while 17 (4.0%) of 422 ASMs were diagnosed with tuberculosis (TB). Of the 373 ASMs tested for HIV, 90 (23.5%) were sero-positive. An HIV infection was associated with a diagnosis of silicosis. There is need for a comprehensive occupational health service package, including TB and silicosis surveillance, for ASMs in Zimbabwe. These are preliminary and limited findings, needing confirmation by more comprehensive studies.


Assuntos
Infecções por HIV , Saúde do Trabalhador , Silicose , Tuberculose , Estudos Transversais , Ouro , Infecções por HIV/epidemiologia , Humanos , Silicose/epidemiologia , Silicose/etiologia , Zimbábue/epidemiologia
3.
Work ; 70(2): 433-442, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34633345

RESUMO

BACKGROUND: Exposure to artificial stone machining, under the conditions in which marble workers work with this new product, can cause silicosis. OBJECTIVE: To examine the experiences of marble workers affected, both in workshop and during home installation of countertops, before diagnosis of silicosis. METHODS: Qualitative study in which 10 open-ended semistructured interviews were conducted with marble workers diagnosed with silicosis after machining artificial stone countertops in Cádiz, Spain. Interviews were recorded, transcribed, and coded using a directed content analysis. Codes were organized into themes. RESULTS: Interviews up to 120 minutes and transcript analysis revealed three themes: 1) Heavy exposure for piecework: construction boom in an environment of labor deregulation and high demand for the novel product; 2) Poor working conditions: dry machining of artificial stone without proper protection in the workshop and greater exposure during home installation of countertops; 3) Concatenated legal transgressions: deficiencies in prevention and health surveillance without safety conditions for the correct handling of artificial stone. CONCLUSIONS: The fight against an emerging occupational disease-artificial stone silicosis-should focus on detecting affected workers and avoiding new cases, forcing joint efforts to achieve rigorous compliance with health surveillance and protecting marble workers to achieve healthy and safe workplaces.


Assuntos
Doenças Profissionais , Exposição Ocupacional , Silicose , Humanos , Exposição Ocupacional/efeitos adversos , Silicose/etiologia , Espanha , Local de Trabalho
4.
Chest ; 159(6): e395-e401, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34099157

RESUMO

CASE PRESENTATION: A 67-year-old woman, who recently immigrated to the United States from Afghanistan, presented to the hospital after sustaining a mechanical fall. She had no significant medical history and was not on any medication routinely. She denied any fever, night sweats, weight loss, shortness of breath, or hemoptysis. The patient had no prior personal history or exposure to TB. Results of a previous purified protein derivative skin test upon immigration were negative.


Assuntos
Carvão Mineral/efeitos adversos , Dispneia , Pulmão , Linfadenopatia , Nódulos Pulmonares Múltiplos , Silicose , Idoso , Biópsia/métodos , Diagnóstico Diferencial , Poeira , Dispneia/diagnóstico , Dispneia/etiologia , Feminino , Humanos , Exposição por Inalação/efeitos adversos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Linfadenopatia/etiologia , Linfadenopatia/patologia , Nódulos Pulmonares Múltiplos/diagnóstico por imagem , Nódulos Pulmonares Múltiplos/etiologia , Nódulos Pulmonares Múltiplos/patologia , Silicose/diagnóstico , Silicose/etiologia , Silicose/fisiopatologia , Cirurgia Torácica Vídeoassistida/métodos , Tomografia Computadorizada por Raios X/métodos
5.
Artigo em Inglês | MEDLINE | ID: mdl-34070293

RESUMO

Occupational exposure to respirable crystalline silica (SiO2) is one of the most common and serious risks because of the health consequences for the workers involved. Silicosis is a progressive, irreversible, and incurable fibrotic lung disease caused by the inhalation of respirable crystalline silica dust. A cross-sectional epidemiological study was carried out to assess the occupational risk factors that may contribute to the onset of silicosis in workers carrying out work activities with the inhalation of silica compact dust. The study population consisted of 311 artificial stone workers from the province of Almeria (southeast of Spain). Among them, 64 were previously diagnosed with silicosis and the rest of the participants (n = 247 workers) were not diagnosed with such a disease. The workers showing a greater risk of developing silicosis were those who installed kitchen worktops at consumers' homes, as they did not use face-masks or were not provided with personal protective equipment (PPE) by their business. The results of this study provide support for the evidence indicating that silicosis is a major emerging health concern for workers in the artificial stone sector. Exposure to crystalline silica dust thus can influence the development of silicosis in those cases where individual and collective protection measures are not used or adequately applied.


Assuntos
Exposição Ocupacional , Silicose , Estudos Transversais , Poeira/análise , Humanos , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/análise , Dióxido de Silício/toxicidade , Silicose/epidemiologia , Silicose/etiologia , Espanha
6.
Rev Mal Respir ; 38(7): 768-772, 2021 Sep.
Artigo em Francês | MEDLINE | ID: mdl-34023191

RESUMO

Silicosis and sarcoidosis are two very distinct entities in the literature. All the additional non-invasive examinations, including the chest CT scan, often do not differentiate them. The history, including occupational exposure to identified silica particles, is a discriminating factor. However, due to the pathogenic power of silica, it would be possible to have the simultaneous development of these two pathologies in the same patient. To illustrate this situation, here is the case of a 62-year-old patient, who presented initially with a picture of dyspnea and productive cough. The chest CT showed micronodular peribronchovascular infiltrates and mediastinal lymphadenopathy. The other additional examinations did not find anything specific. In the diagnostic process, the patient had multiple endoscopic samples which did not make it possible to be conclusive on one or the other of these pathologies. He therefore underwent a surgical lung biopsy which revealed histological lesions compatible with the two pathologies. Recent studies suggest that inhaled particles, especially silica, could be responsible for the pattern of sarcoidosis. However, it is difficult to say whether, in this case, silica was responsible for the development of sarcoidosis.


Assuntos
Sarcoidose , Silicose , Humanos , Pulmão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Sarcoidose/diagnóstico , Dióxido de Silício/toxicidade , Silicose/diagnóstico , Silicose/etiologia , Tomografia Computadorizada por Raios X
7.
J Cell Mol Med ; 25(9): 4466-4477, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33834616

RESUMO

Macrophages play a key role in silicosis, and exosomes are potent mediators of intercellular communication. This suggests that macrophage-derived exosomes have a potential contribution to the pathogenesis of silicosis. To investigate whether macrophage-derived exosomes promote or inhibit lung fibrosis, in vitro, silica-exposed macrophage-derived exosomes (SiO2 -Exos) were collected and cocultured with fibroblasts. The expression of collagen I and α-SMA was evaluated. Furthermore, the endoplasmic reticulum (ER) stress markers BIP, XBP1s and P-eIF2α were assessed after treatment with or without the ER stress inhibitor 4-PBA. In vivo, mice were pre-treated with the exosome secretion inhibitor GW4869 prior to silica exposure. After sacrifice, lung tissues were histologically examined, and the expression of proinflammatory cytokines (TNF-α, IL-1ß and IL-6) in bronchoalveolar lavage fluid (BALF) was measured. The results showed that the expression of collagen I and α-SMA was up-regulated after treatment with SiO2 -Exos, accompanied by increased expression of BIP, XBP1s and P-eIF2α. Pre-treatment with 4-PBA reversed this effect. More importantly, an in vivo study demonstrated that pre-treatment with GW4869 decreased lung fibrosis and the expression of TNF-α, IL-1ß and IL-6 in BALF. These results suggested that SiO2 -Exos are profibrogenic and that the facilitating effect is dependent on ER stress.


Assuntos
Estresse do Retículo Endoplasmático , Exossomos/fisiologia , Fibroblastos/patologia , Macrófagos/fisiologia , Fibrose Pulmonar/patologia , Dióxido de Silício/toxicidade , Silicose/patologia , Animais , Comunicação Celular , Citocinas , Fibroblastos/metabolismo , Macrófagos/citologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Fibrose Pulmonar/etiologia , Fibrose Pulmonar/metabolismo , Transdução de Sinais , Silicose/etiologia , Silicose/metabolismo
8.
Artigo em Chinês | MEDLINE | ID: mdl-33691377

RESUMO

Artificial quartz stone is a new type of decorative building material, there are serious dust exposure hazards during the production and processing. Due to the lack of effective health protection for practitioners, silicosis caused by artificial quartz stone dust has been widely reported worldwide in recent years, which seriously affect the health of practitioners. This article summarizes the use status of artificial quartz stone, the exposure of practitioners and the lung tissue damage caused by dust, analyzes its pathogenic characteristics, and provides a basis for protecting the occupational population and improving occupational health.


Assuntos
Exposição Ocupacional , Silicose , Poeira , Humanos , Pulmão , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/análise , Quartzo/toxicidade , Dióxido de Silício , Silicose/etiologia
9.
Am J Ind Med ; 64(6): 511-518, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33774816

RESUMO

BACKGROUND: Artisanal and small-scale mining (ASM) are an important source of employment in southern Brazil. Mining workers are frequently exposed to unhealthy work conditions which increase the risk of occupational diseases. In this study, we assessed the association of sociodemographic factors and the occupational history of artisanal mining workers with the risk of adverse respiratory outcomes. METHODS: The study was conducted with 258 artisanal mining workers in southern Brazil, who were exposed to dust (mainly crystalline silica) in their work. Information on sociodemographic variables and occupational histories was collected between 2017 and 2018. To estimate the worker's exposure to inhalable dust we use the Advanced REACH (Registration, Evaluation, and Authorization of Chemicals) Tool (ART). RESULTS: Study participants were all men, with an average age of 40 years. Median crude dust exposure estimated by ART was 13.2 mg/m³ and median crude crystalline silica exposure was 1.6 mg/m3 . The prevalence ratio (PR) for self-reported silicosis was 3.08 (95% confidence interval, 1.39-7.17) in workers with 20 years or more of mining work. Factors associated with silicosis were age, pack-years of tobacco use, and body mass index. Smokers were over twice as likely to report respiratory symptoms. CONCLUSIONS: Our findings indicate that a high prevalence of silicosis and other associated diseases in mining workers is associated with both unhealthy work environment conditions and the health profile of workers. This study is an important step for understanding health outcomes from work in ASM.


Assuntos
Poeira , Mineração , Exposição Ocupacional/efeitos adversos , Dióxido de Silício , Silicose/epidemiologia , Adulto , Brasil/epidemiologia , Ouro , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Silicose/etiologia
10.
Occup Environ Med ; 78(4): 296-302, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33115923

RESUMO

OBJECTIVES: The popularity of high silica content artificial stone has been associated with emergence of severe, progressive silicosis as a major health issue affecting workers in the stone benchtop industry. This population-based health assessment programme has been implemented with the aim of identifcation of silica-associated disease at a preclinical stage. METHODS: All current and former workers from the stone benchtop industry in the State of Victoria are offered free health assessments. Primary evaluations include a standardised questionnaire, physical examination, spirometry and gas transfer assessment and International Labour Organisation-categorised chest X-ray. Secondary evaluations include high-resolution CT chest, blood tests and a respiratory physician evaluation. RESULTS: At the end of the first 12 months, 86/239 (36%) workers who had completed secondary evaluation were diagnosed with silicosis (65 simple silicosis and 21 complicated silicosis). 22 had worked in the industry for less than 10 years at the time of diagnosis. Of those with simple silicosis, 80% of workers reported breathlessness only with strenuous exercise (modified Medical Research Council score of 0), and lung function was well preserved (prebronchodilator forced vital capacity mean 99.8% predicted (SD 13.6), diffusion capacity of the lung for carbon monoxide mean 96.2% predicted (SD 18.0)). Antinuclear antibodies were detected in 37% with silicosis and 24% without silicosis. CONCLUSION: Early results from this comprehensive health assessment programme have indicated a high proportion of referred artificial stone benchtop workers have silicosis, including many with early-stage disease. The common finding of antinuclear antibodies suggest significant potential for autoimmune disease in this occupational group.


Assuntos
Manufaturas/efeitos adversos , Doenças Profissionais/etiologia , Exposição Ocupacional/efeitos adversos , Silicose/etiologia , Adulto , Anticorpos Antinucleares/sangue , Feminino , Humanos , Masculino , Doenças Profissionais/epidemiologia , Exame Físico , Troca Gasosa Pulmonar , Radiografia Torácica , Fatores de Risco , Silicose/epidemiologia , Espirometria , Inquéritos e Questionários , Tomografia Computadorizada por Raios X , Vitória/epidemiologia
11.
J Occup Environ Med ; 63(1): 74-79, 2021 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33122539

RESUMO

OBJECTIVES: To investigate the effect of sex on the risk of silicosis and to explore any interaction between cigarette smoking and sex in the development of silicosis. METHODS: The cohort was selected from eight Chinese pottery factories. Diagnoses of silicosis were based on 1986 Chinese pneumoconiosis Roentgen diagnostic criteria. Data on cigarette smoking were collected by face-to-face interviews in 1989 and 2003. RESULTS: Eight thousand eight hundred and eighty seven dust-exposed workers were included. Men had a 77% higher incidence of silicosis than women. At lower pack-years of smoking, men were 72% more at risk than women. The latency period was found to be longest in female never-smokers and shortest in female ever-smokers. CONCLUSIONS: Men had a higher risk of developing silicosis than women. Cigarette smoking increased the risk in both sexes, more so in women.


Assuntos
Exposição Ocupacional , Silicose , China/epidemiologia , Estudos de Coortes , Poeira/análise , Feminino , Humanos , Masculino , Exposição Ocupacional/efeitos adversos , Fatores de Risco , Silicose/epidemiologia , Silicose/etiologia
13.
Toxicol Appl Pharmacol ; 409: 115282, 2020 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-33068622

RESUMO

Hydraulic fracturing ("fracking") is used in unconventional gas drilling to allow for the free flow of natural gas from rock. Sand in fracking fluid is pumped into the well bore under high pressure to enter and stabilize fissures in the rock. In the process of manipulating the sand on site, respirable dust (fracking sand dust, FSD) is generated. Inhalation of FSD is a potential hazard to workers inasmuch as respirable crystalline silica causes silicosis, and levels of FSD at drilling work sites have exceeded occupational exposure limits set by OSHA. In the absence of any information about its potential toxicity, a comprehensive rat animal model was designed to investigate the bioactivities of several FSDs in comparison to MIN-U-SIL® 5, a respirable α-quartz reference dust used in previous animal models of silicosis, in several organ systems (Fedan, J.S., Toxicol Appl Pharmacol. 00, 000-000, 2020). The present report, part of the larger investigation, describes: 1) a comparison of the physico-chemical properties of nine FSDs, collected at drilling sites, and MIN-U-SIL® 5, a reference silica dust, and 2) a comparison of the pulmonary inflammatory responses to intratracheal instillation of the nine FSDs and MIN-U-SIL® 5. Our findings indicate that, in many respects, the physico-chemical characteristics, and the biological effects of the FSDs and MIN-U-SIL® 5 after intratracheal instillation, have distinct differences.


Assuntos
Poluentes Ocupacionais do Ar/efeitos adversos , Exposição por Inalação/efeitos adversos , Pulmão/efeitos dos fármacos , Areia/química , Silicose/etiologia , Traqueia/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Poeira , Fraturamento Hidráulico/métodos , Masculino , Exposição Ocupacional/efeitos adversos , Pneumonia/induzido quimicamente , Quartzo/efeitos adversos , Ratos , Ratos Sprague-Dawley , Dióxido de Silício/efeitos adversos
14.
Respirology ; 25(11): 1193-1202, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33051927

RESUMO

Coal mine lung dust disease (CMDLD) and artificial stone (AS) silicosis are preventable diseases which have occurred in serious outbreaks in Australia recently. This has prompted a TSANZ review of Australia's approach to respiratory periodic health surveillance. While regulating respirable dust exposure remains the foundation of primary and secondary prevention, identification of workers with early disease assists with control of further exposure, and with the aims of preserving lung function and decreasing respiratory morbidity in those affected. Prompt detection of an abnormality also allows for ongoing respiratory specialist clinical management. This review outlines a medical framework for improvements in respiratory surveillance to detect CMDLD and AS silicosis in Australia. This includes appropriate referral, improved data collection and interpretation, enhanced surveillance, the establishment of a nationwide Occupational Lung Disease Registry and an independent advisory group. These measures are designed to improve health outcomes for workers in the coal mining, AS and other dust-exposed and mining industries.


Assuntos
Antracose , Carvão Mineral/efeitos adversos , Doenças Profissionais , Exposição Ocupacional , Dióxido de Silício/efeitos adversos , Silicose , Antracose/diagnóstico , Antracose/epidemiologia , Antracose/prevenção & controle , Austrália/epidemiologia , Poeira/prevenção & controle , Humanos , Manufaturas/efeitos adversos , Nova Zelândia/epidemiologia , Doenças Profissionais/epidemiologia , Doenças Profissionais/etiologia , Doenças Profissionais/prevenção & controle , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/prevenção & controle , Saúde do Trabalhador , Silicose/epidemiologia , Silicose/etiologia , Silicose/prevenção & controle
15.
Sci Rep ; 10(1): 14364, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32873894

RESUMO

Respiratory diseases, including pulmonary fibrosis, silicosis, and allergic pneumonia, can be caused by long-term exposure to dental prosthesis grinding dust. The extent of the toxicity and pathogenicity of exposure to PMMA dust, Vitallium dust, and dentin porcelain dust differs. The dust from grinding dental prosthesis made of these three materials was characterized in terms of morphology, particle size, and elemental composition. The adverse effects of different concentrations of grinding dust (50, 150, 300, 450, and 600 µg ml-l) on RAW264.7 macrophages were evaluated, including changes in cell morphology and the production of lactate dehydrogenase (LDH) and reactive oxygen species (ROS). The dust particles released by grinding dental prosthesis made of these materials had different morphologies, particle sizes, and elemental compositions. They also induced varying degrees of cytotoxicity in RAW264.7 macrophages. A possible cytotoxicity mechanism is the induction of lipid peroxidation and plasma membrane damage as the dust particles penetrate cells. Therefore, clinicians who regularly work with these materials should wear the appropriate personal protection equipment to minimize exposure and reduce the health risks caused by these particulates.


Assuntos
Sobrevivência Celular/efeitos dos fármacos , Porcelana Dentária/toxicidade , Prótese Dentária , Poeira/análise , Macrófagos/efeitos dos fármacos , Polimetil Metacrilato/toxicidade , Vitálio/toxicidade , Animais , Porcelana Dentária/química , Odontólogos , Camundongos , Microscopia de Fluorescência , Exposição Ocupacional/efeitos adversos , Exposição Ocupacional/análise , Tamanho da Partícula , Pneumonia Aspirativa/induzido quimicamente , Polimetil Metacrilato/química , Fibrose Pulmonar/induzido quimicamente , Células RAW 264.7 , Silicose/etiologia , Vitálio/química
16.
Med Lav ; 111(3): 222-231, 2020 Jun 26.
Artigo em Italiano | MEDLINE | ID: mdl-32624564

RESUMO

BACKGROUND: Severe silicosis from occupational exposure to calcined diatomaceous earth has been observed in the past, due to the high-temperature transformation of amorphous silica in crystalline phases, mainly cristobalite. In dental alginate production and use a silica exposure may be underestimated. OBJECTIVES: To describe the clinical picture, the scenario and pattern of occupational exposure to silica and the corresponding necroscopic findings of a case of silicosis in a worker engaged in the production of alginates for dental use. METHODS: A commercial sample of calcinated diatomaceous earth and necroscopic lung samples were analysed by scanning electron microscopy (SEM-EDS) and X-ray diffraction (XRD) for the quali-quantitative determination of crystalline silica. Material safety data sheets (MSDSs) of diatomaceous earth produced in 2002 and 2018 were examined to assess the information content on silicosis risk. Clinical findings and post-mortem examinations of the worker are evaluated. RESULTS: A cristobalite concentration of 36% (wt/wt) was determined in the diatomaceous earth sample and a large amount of diatom fragments were observed in lung samples. The DRX spectra indicated the presence of cristobalite either in the bulk sample or in the lung tissues. The MSDS dated 2002 reported the presence of SLC up to 63% with cristobalite concentrations minor of 60%, and the resulting risk of silicosis, while the MSDS dated 2018 and referred to a commercial product currently on the market indicated a concentration of cristobalite minor of 1% and no risk of silicosis. The worker was suffering from a severe silicosis, histologically confirmed by necropsy. CONCLUSION: The present case-study revealed that the risk of silicosis from calcined diatomaceous earths used to produce dental alginates has been ignored. The lack of engineering controls and personal protection measures led to a high cristobalite lung burden, consistent with the development of a severe silicosis that were a contributing factor of death. A MSDS of a commercial product currently on the market does not report this serious hazard.


Assuntos
Terra de Diatomáceas , Exposição Ocupacional , Silicose , Alginatos , Terra de Diatomáceas/efeitos adversos , Humanos , Dióxido de Silício , Silicose/etiologia
17.
Rev. Asoc. Esp. Espec. Med. Trab ; 29(2): 35-39, jun. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-ET5-1967

RESUMO

INTRODUCCIÓN: La silicosis es una enfermedad generalmente de origen ocupacional. La sarcoidosis es una enfermedad multisistémica de etiología desconocida. Los patrones radiológicos de silicosis y sarcoidosis pueden ser similares. EXPOSICIÓN DEL CASO: Varón de 42 años, marmolista de profesión, diagnosticado de sarcoidosis y que presenta radiológicamente adenopatías hiliares y nódulos pulmonares en ambos lóbulos. Se declara sospecha de origen profesional de silicosis, ratificándose posteriormente por el Instituto Nacional de la Seguridad Social. DISCUSIÓN: El diagnostico de silicosis se sustenta en la concurrencia de los siguientes criterios: - Historia laboral de exposición a sílice cristalina. - Radiografía de tórax simple con profusiones > o = a 1/1 (clasificación ILO). - Exclusión de otras entidades posibles. La sarcoidosis se caracteriza patológicamente por la presencia de granulomas no caseificantes en los órganos involucrados. CONCLUSIONES: El contexto clínico y laboral de la enfermedad es crucial para poder establecer un diagnóstico correcto


INTRODUCTION: Silicosis is a disease usually of occupational origin. Sarcoidosis is a multisystemic disease of unknown etiology. The radiological patterns of silicosis and sarcoidosis can be similar. CASE STATEMENT: A 42 years old male, marbleist, diagnosed of sarcoidosis and who presents radiological hilar adenopathies and pulmonary nodules in both lobes. Suspicion of professional origin of silicosis is declared, subsequently ratified by the National Institute of Security Social. DISCUSSION: The diagnosis of silicosis is based on the concurrence of the following criteria: - Work history of exposure to crystalline silica. - Simple chest x-ray with profusions > o = 1/1 (ILO classification). - Exclusion of other possible entities. Sarcoidosis is pathologically characterized by the presence of non-caseating granulomata in the organs involved. CONCLUSIONS: The clinical and occupational context of the disease is crucial in order to establish a correct diagnosis


Assuntos
Humanos , Masculino , Adulto , Sarcoidose Pulmonar/diagnóstico por imagem , Silicose/etiologia , Silicose/diagnóstico por imagem , Dióxido de Silício/efeitos adversos , Doenças Profissionais/induzido quimicamente , Diagnóstico Diferencial , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Doenças Pulmonares Intersticiais/induzido quimicamente , Exposição Ocupacional , Tomografia Computadorizada por Raios X
18.
Rev. Asoc. Esp. Espec. Med. Trab ; 29(2): 35-39, jun. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-193752

RESUMO

INTRODUCCIÓN: La silicosis es una enfermedad generalmente de origen ocupacional. La sarcoidosis es una enfermedad multisistémica de etiología desconocida. Los patrones radiológicos de silicosis y sarcoidosis pueden ser similares. EXPOSICIÓN DEL CASO: Varón de 42 años, marmolista de profesión, diagnosticado de sarcoidosis y que presenta radiológicamente adenopatías hiliares y nódulos pulmonares en ambos lóbulos. Se declara sospecha de origen profesional de silicosis, ratificándose posteriormente por el Instituto Nacional de la Seguridad Social. DISCUSIÓN: El diagnostico de silicosis se sustenta en la concurrencia de los siguientes criterios: - Historia laboral de exposición a sílice cristalina. - Radiografía de tórax simple con profusiones > o = a 1/1 (clasificación ILO). - Exclusión de otras entidades posibles. La sarcoidosis se caracteriza patológicamente por la presencia de granulomas no caseificantes en los órganos involucrados. CONCLUSIONES: El contexto clínico y laboral de la enfermedad es crucial para poder establecer un diagnóstico correcto


INTRODUCTION: Silicosis is a disease usually of occupational origin. Sarcoidosis is a multisystemic disease of unknown etiology. The radiological patterns of silicosis and sarcoidosis can be similar. CASE STATEMENT: A 42 years old male, marbleist, diagnosed of sarcoidosis and who presents radiological hilar adenopathies and pulmonary nodules in both lobes. Suspicion of professional origin of silicosis is declared, subsequently ratified by the National Institute of Security Social. DISCUSSION: The diagnosis of silicosis is based on the concurrence of the following criteria: - Work history of exposure to crystalline silica. - Simple chest x-ray with profusions > o = 1/1 (ILO classification). - Exclusion of other possible entities. Sarcoidosis is pathologically characterized by the presence of non-caseating granulomata in the organs involved. CONCLUSIONS: The clinical and occupational context of the disease is crucial in order to establish a correct diagnosis


Assuntos
Humanos , Masculino , Adulto , Sarcoidose Pulmonar/diagnóstico por imagem , Silicose/etiologia , Silicose/diagnóstico por imagem , Dióxido de Silício/efeitos adversos , Doenças Profissionais/induzido quimicamente , Diagnóstico Diferencial , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Doenças Pulmonares Intersticiais/induzido quimicamente , Exposição Ocupacional , Tomografia Computadorizada por Raios X
19.
Work ; 66(1): 193-200, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32417826

RESUMO

BACKGROUND: Semi-precious stone mining may cause occupational lung disease. The impact of inhaling silica on workers' exercise capacity has only been partially studied. OBJECTIVES: To study lung function, exercise capacity, and identify factors associated with functional impairment. METHODS: In a cross-sectional study of 193 current miners from Ametista do Sul, Rio Grande do Sul, Brazil, medical and occupational data were collected. The diagnosis of silicosis was established by the history of dust exposure and chest radiographic findings. All workers performed a spirometry and a 6-minute walk test (6MWT). RESULTS: Of the sample 51 (26.4%) had silicosis. Time working in mine was 14.7±8.7 years. Spirometry showed a normal, restrictive or obstructive ventilatory pattern in 75.1 %, 13 % and 9.3 % of the workers, respectively. The diagnosis of silicosis and length of time working in mining negatively affected lung function, although exercise capacity was preserved. In the multivariate analysis, time working in mining, diagnosis of silicosis and education remained significant for forced expiratory volume in one second (FEV1; r = 0.60; r2 = 0.36; p < 0.001) and age and height for distance in 6MWT (r = 0.66; r2 = 0.43; p < 0.001). CONCLUSIONS: Our results show impaired lung function and preserved exercise capacity in current mineworkers exposed to silica. Length of time working in mining, presence of silicosis and lower education were factors associated with reduced lung function.


Assuntos
Tolerância ao Exercício/fisiologia , Volume Expiratório Forçado , Mineradores , Silicose/fisiopatologia , Adulto , Brasil , Estudos Transversais , Escolaridade , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/epidemiologia , Exposição Ocupacional/análise , Radiografia Torácica , Silicose/etiologia , Capacidade Vital
20.
Mediators Inflamm ; 2020: 2683753, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32351319

RESUMO

Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. In this study, serum from subjects with silicosis (n = 59) or from healthy controls (HC, n = 14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), transforming growth factor-ß1 (TGF-ß1), and oxidized low-density lipoprotein (ox-LDL). The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson's correlation analyses. Mean levels of serum sRAGE were lower in silicosis than those in controls (p < 0.05). The subjects who had a longer term of occupational exposure had higher levels of sRAGE (p < 0.05). The secretion of TNF-α, IL-1ß, IL-6, TGF-ß1, and ox-LDL was significantly higher in the silicosis group than that in the HC group (p < 0.05). Furthermore, the levels of sRAGE were negatively correlated with TNF-α, IL-6, IL-1ß, and ox-LDL. There is no correlation between sRAGE and TGF-ß1 and lung function. The optimal point of sRAGE for differentiating silicosis from healthy controls was 14250.02 pg/ml by ROC curve analysis. A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis.


Assuntos
Inflamação/etiologia , Receptor para Produtos Finais de Glicação Avançada/sangue , Silicose/sangue , Adulto , Citocinas/sangue , Feminino , Humanos , Inflamação/sangue , Lipoproteínas LDL/sangue , Masculino , Pessoa de Meia-Idade , Silicose/etiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...