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1.
BMC Oral Health ; 22(1): 265, 2022 06 29.
Artigo em Inglês | MEDLINE | ID: mdl-35768820

RESUMO

BACKGROUND: Schwannomas or neurilemmomas are well-encapsulated, benign, solitary, and slow-growing tumors that originate from Schwann cells of the nerve sheath. Extracranial schwannoma is reported to have a relatively high incidence in the tongue while an extremely low incidence in the floor of mouth. In the current study, we presented the first case series of hypoglossal nerve-derived schwannoma in the floor of mouth in Asia. METHODS: A retrospective study of 9 surgical cases of hypoglossal nerve-derived schwannoma in the floor of mouth was performed. The patient and tumor characteristics were evaluated by physical, radiological and pathological examination. Details of operation and complications were also recorded. RESULTS: Hypoglossal nerve-derived schwannoma in the floor of mouth showed a well-defined boundary with a firm texture, smooth surface and good mobility on palpation. The median maximum diameter of the tumors was 4.3 cm (range 2.8-7.0 cm). The median operative time and bleeding volumes were 89.4 min (range 47-180 min) and 99.2 mL (range 15-200 mL), respectively. All cases received complete surgical excision. CONCLUSION: In this study, we presented the diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth for the first time in Asia. The study provided us with a recommendation for consideration of the diagnosis of hypoglossal schwannoma when a patient presents with a mass in the floor of mouth.


Assuntos
Neoplasias dos Nervos Cranianos , Doenças do Nervo Hipoglosso , Neurilemoma , Neoplasias dos Nervos Cranianos/diagnóstico , Neoplasias dos Nervos Cranianos/patologia , Neoplasias dos Nervos Cranianos/cirurgia , Humanos , Nervo Hipoglosso/patologia , Nervo Hipoglosso/cirurgia , Doenças do Nervo Hipoglosso/diagnóstico , Doenças do Nervo Hipoglosso/etiologia , Doenças do Nervo Hipoglosso/cirurgia , Soalho Bucal/patologia , Soalho Bucal/cirurgia , Neurilemoma/diagnóstico por imagem , Neurilemoma/cirurgia , Estudos Retrospectivos
2.
Rev. cir. traumatol. buco-maxilo-fac ; 22(2): 39-41, abr.-jun. 2022. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1399234

RESUMO

Introdução: Rânula é um fenômeno de extravasamento de muco, também chamado cisto de retenção de muco, que ocorre especificamente no soalho bucal. A origem da mucina extravasada é usualmente da glândula sublingual, podendo, porém, se originar do ducto da glândula submandibular ou, ainda, das glândulas salivares menores presentes no soalho de boca. Rânulas de dimensões maiores usualmente originam se do corpo da glândula sublingual. Relato de caso: Este trabalho descreve um caso em uma criança de 5 anos de idade com uma rânula em região lateral esquerda de língua, e discutir questões sobre o tratamento desta patologia. Considerações finais: Há várias formas de tratamento, sendo as mais usadas a marsupialização, concomitante ou não com a excisão cirúrgica da lesão e da glândula salivar envolvida... (AU)


Introduction: Ranula is a phenomenon of mucus leakage, also called mucus retention cyst, which occurs specifically in the mouth floor. The origin of the extravasated mucin is usually from the sublingual gland, but it can originate from the duct of the submandibular gland or even from the minor salivary glands it presents on the floor of the mouth. Larger sized ranulas usually arise from the body of the sublingual gland. Case report: This work is a case in a 5-year-old child with a ranula in the left tongue region, and discuss about the treatment of this pathology. Final considerations: There are several forms of treatment, the most used being marsupialization, concomitant or not with a surgical excision of the lesion and the involved salivary gland... (AU)


Introducción: Ránula es un fenómeno de fuga de moco, también llamado quiste de retención de moco, que ocurre específicamente en el piso de la boca. El origen de la mucina extravasada suele ser de la glándula sublingual, pero puede originarse en el conducto de la glándula submandibular o incluso en las glándulas salivales menores presentes en el suelo de la boca. Las ranulas de mayor tamaño generalmente surgen del cuerpo de la glándula sublingual. Reporte de caso: Este artículo describe un caso en un niño de 5 años con una ránula en la región lateral izquierda de la lengua y analiza cuestiones sobre el tratamiento de esta patología. Consideraciones finales: Existen varias formas de tratamiento, siendo las más utilizadas la marsupialización, concomitante o no con la exéresis quirúrgica de la lesión y de la glándula salival afectada... (AU)


Assuntos
Humanos , Feminino , Pré-Escolar , Doenças das Glândulas Salivares , Glândulas Salivares Menores , Glândula Sublingual , Cistos , Boca , Soalho Bucal/patologia
3.
J Oral Maxillofac Surg ; 80(3): 553-558, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34871585

RESUMO

PURPOSE: The lingual lymph node (LLN) located on the internal surface of mylohyoid muscle is not currently included in oral cavity cancer surgery or conventional neck dissection. We investigated the risk factors for LLN metastasis and evaluated its oncologic significance in patients with oral tongue and floor of mouth squamous cell carcinoma. PATIENTS AND METHODS: Adult patients (≥20 years) undergoing upfront surgery and LLN dissection for oral tongue and floor of mouth squamous cell carcinoma between 2009 and 2018 were retrospectively analyzed. Patients who had relapsed after previous treatment or had neoadjuvant chemotherapy or had not undergone surgery were excluded. Association between clinicopathological risk factors (age, gender, tumor differentiation, stage, lymphatic invasion, perineural invasion, vascular invasion, metastatic lymph node ratio, and extranodal extension) and LLN metastasis was evaluated using logistic regression analysis. Disease-free survival in accordance with LLN metastasis was evaluated by the Kaplan-Meier method. RESULTS: A total of 51 patients were included, and LLN metastasis was found in 9 patients (17.6%). LLN metastasis was significantly associated with advanced nodal stage, poor tumor differentiation, and vascular invasion. Cox proportional-hazards regression models showed that LLN metastasis was associated with an 8.0-fold higher risk of mortality than the absence of LLN metastasis. Patients with LLN metastasis had significantly worse 5-year disease-free survival rate than those without metastasis (22.2% vs 85.7%; P < .001). CONCLUSIONS: This study suggests that LLN metastasis is a poor prognostic factor in patients with oral tongue and floor of mouth squamous cell carcinoma. The sublingual space should be carefully evaluated preoperatively and intraoperatively.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Bucais , Adulto , Carcinoma de Células Escamosas/patologia , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Linfonodos/patologia , Soalho Bucal/patologia , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Língua/patologia
4.
J Stomatol Oral Maxillofac Surg ; 123(3): e106-e111, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-34224923

RESUMO

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adulthood and usually occurs in the limbs, trunk, and peritoneum. Less than 10% of MFH cases occur in the head and neck region. The clinical manifestations and pathological features of MFH are atypical, and it is difficult to make a clinical diagnosis. We describe a rare case of MFH of the floor of mouth and provide our diagnosis and treatment experiences. Through this review, we also evaluate the origin, World Health Organization (WHO) classification, clinical presentations, pathological features, treatment methods, and prognosis of MFH. MFH may originate from fibroblasts or primitive mesenchymal cells. MFH was defined as undifferentiated pleomorphic sarcoma in the 2002 WHO classification of bone and soft tissue tumors. The most common manifestation of MFH is a painless enlarging nodule, often without overlying epidermal ulcers. Jaw lesions are usually found after displays of swelling, pain, paresthesia, and loose teeth. MFH is composed of pleomorphic spindle cells, usually with hemorrhage, necrosis, and lymphocyte infiltration. The main treatment method is surgical resection. Moreover, radiotherapy and chemotherapy have certain auxiliary effects. The local recurrence and distant metastasis of MFH are common, and the prognosis is poor. Therefore, determining the histopathological features of MFH and conducting appropriate immunohistochemical examinations are crucial in establishing the correct diagnosis. In-depth study is required in order to have a better understanding of head and neck MFH.


Assuntos
Histiocitoma Fibroso Maligno , Neoplasias de Tecidos Moles , Adulto , Edema , Histiocitoma Fibroso Maligno/diagnóstico , Histiocitoma Fibroso Maligno/cirurgia , Humanos , Soalho Bucal/patologia , Prognóstico , Neoplasias de Tecidos Moles/patologia
5.
BMC Cancer ; 21(1): 922, 2021 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-34391381

RESUMO

OBJECTIVE: Tongue and mouth floor squamous cell carcinoma (T/MF SCC) exhibits a high rate of local recurrence and cervical lymph node metastasis. The effect of the tumor microenvironment on T/MF SCC remains unclear. MATERIALS AND METHODS: Transcriptome and somatic mutation data of patients with T/MF SCC were obtained from HNSC projects of the Cancer Genome Atlas. Immune infiltration quantification in early- (clinical stage I-II) and advanced-stage (clinical stage III-IV) T/MF SCC was performed using single sample Gene Set Enrichment Analysis and MCPcounter. Differentially expressed gene data were filtered, and their function was assessed through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. Kaplan-Meier survival curve analysis and Cox regression model were conducted to evaluate the survival of patients with the CCL22 signature. Maftools was used to present the overview of somatic mutations. RESULTS: In T/MF SCC, T helper (Th)2 cell counts were significantly increased in patients with early-stage disease compared to those with advanced-stage disease. Expression of the Th2 cell-related chemokine, CCL22, was downregulated in patients with advanced-stage T/MF SCC. Univariate and multivariate Cox analyses revealed that CCL22 was a good prognostic factor in T/MF SCC. A nomogram based on the expression of CCL22 was constructed to serve as a prognostic indicator for T/MF SCC. NOTCH1 mutations were found at a higher rate in patients with advanced-stage T/MF SCC than in those with early-stage T/MF SCC, resulting in the inhibition of the activation of the NOTCH1-Th2 cell differentiation pathway. The expression levels of CCL22, GATA-3, and IL4 were higher in patients with early-stage T/MF SCC than in those with advanced-stage T/MF SCC. CONCLUSION: In T/MF SCC, high expression of CCL22 may promote the recruitment of Th2 cells and help predict a better survival. Mutations in NOTCH1 inhibit the differentiation of Th2 cells, facilitating tumor progression through a decrease in Th2 cell recruitment and differentiation.


Assuntos
Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/metabolismo , Quimiocina CCL22/genética , Neoplasias Bucais/etiologia , Neoplasias Bucais/metabolismo , Receptor Notch1/genética , Células Th2/imunologia , Células Th2/metabolismo , Adulto , Idoso , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Quimiotaxia de Leucócito/genética , Quimiotaxia de Leucócito/imunologia , Biologia Computacional/métodos , Feminino , Fator de Transcrição GATA3/genética , Fator de Transcrição GATA3/metabolismo , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Humanos , Estimativa de Kaplan-Meier , Contagem de Linfócitos , Linfócitos do Interstício Tumoral , Masculino , Pessoa de Meia-Idade , Soalho Bucal/metabolismo , Soalho Bucal/patologia , Neoplasias Bucais/mortalidade , Neoplasias Bucais/patologia , Mutação , Estadiamento de Neoplasias , Prognóstico , Modelos de Riscos Proporcionais
6.
BMC Cancer ; 21(1): 225, 2021 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-33663427

RESUMO

BACKGROUND: Our goal was to analyze the incidence of level VI metastasis in previously untreated oral squamous cell carcinoma (SCC) patients and their clinicopathological and prognostic characteristics. METHODS: Oral SCC patients with level VI metastasis were retrospectively enrolled, and their demographic and pathologic features as well as their survival data were descriptively analyzed. RESULTS: A total of 13 cases from 1875 patients were included, all patients had SCC at the floor of mouth (SCCFOM). Eight (61.5%) patients had a pT4 tumor, and all patients had a pathological N3 neck with multiple positive lymph nodes. Adverse pathologic features were present in 100% of the patients. The size of the metastatic foci in level VI ranged from 2.6 cm to 4.5 cm with a mean value of 3.2 cm, and 5 patients showed a soft tissue deposit with no lymph node component. Recurrence occurred in all patients, and 11 patients died of uncontrolled cancer within 5 years after surgery. CONCLUSION: Level VI metastasis in primary oral SCCFOM is rare, and its prognosis is poor.


Assuntos
Soalho Bucal/patologia , Neoplasias Bucais/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Adulto , Idoso , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/mortalidade , Pescoço/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/mortalidade
7.
Br J Oral Maxillofac Surg ; 59(1): 5-15, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33143945

RESUMO

Complete tumour resection (R0 margin) is an axiom of surgical oncology. Oral cancer ablation is challenging, due to anatomical, functional, and aesthetic considerations. R0 margin is strongly linked to better survival outcomes with great variation in the R0 % across units. This is commonly attributed to disease biology. Without disputing the importance of biological characteristics, we contend that image-based anatomical surgical planning has an important role to play in achieving complete resection. Here, we present our approach utilising cross-sectional imaging, anatomical characteristics and spatial awareness in planning resections for floor of mouth (FOM) and oral tongue cancers. We highlight the challenge of controlling the deep tumour margin lingual to mandible due to anterior vector constraints and emphasise the importance of resecting the genial muscles in a planned fashion and that any rim resection should be obliquely sagittal. In resecting lateral FOM tumours, assessing extension to the parapharyngeal fat is crucial; and mandibular rim resection at a sagittal plane below the mylohyoid line is often required. Assessing the proximity of the contralateral neurovascular pedicle, pre-epiglottic space and hyoid bone are crucial parameters to determine the extent of tongue tumour resection. Our cohort included 173 patients with FOM SCC and 299 patients with tongue SCC. Six patients (3.5%) from the FOM group and eight patients (3%) from the tongue group had involved (R1) margins following surgery. This was associated with local relapse (p<0.05). In conclusion, we demonstrate that image-based planning can aid achieving R0 resections and reduce disease relapse.


Assuntos
Neoplasias de Cabeça e Pescoço , Neoplasias da Língua , Estética Dentária , Humanos , Soalho Bucal/diagnóstico por imagem , Soalho Bucal/patologia , Soalho Bucal/cirurgia , Recidiva Local de Neoplasia/patologia , Estadiamento de Neoplasias , Língua/diagnóstico por imagem , Língua/patologia , Língua/cirurgia , Neoplasias da Língua/diagnóstico por imagem , Neoplasias da Língua/patologia , Neoplasias da Língua/cirurgia
8.
Rev. esp. cir. oral maxilofac ; 42(3): 136-138, jul.-sept. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-196630

RESUMO

Se presenta el caso de una paciente mujer de 67 años que acudió al Servicio de Urgencias del Hospital Universitario 12 de Octubre derivada de otro centro por sospecha de un absceso cervical de origen odontogénico. Sin embargo, la exploración física sugería una glándula sublingual herniada hacia el espacio submental y el TC informaba de una imagen en reloj de arena, pero el resultado histopatológico no fue ni de ránula sublingual ni de quiste dermoide. A propósito de este caso, se ha llevado a cabo una revisión bibliográfica de las lesiones frecuentemente encontradas en el suelo de la boca y la región cervical


A 67-year-old woman attended the Emergency Care Unit at 12 de Octubre Hospital with the suspicion of an odontogenic abscess diagnosed in another hospital. She presented with pain at lower left canine and growing submental mass. However, clinical examination suggested a plunging ranula and CT scan showed a "clock sand-like" image which is typical in dermoid cysts. Anatomic pathology confirmed that the mass was a lymphangioma. A literature review has been done to understand and differentiate masses that can be found in this region


Assuntos
Humanos , Feminino , Idoso , Soalho Bucal/patologia , Neoplasias Bucais/patologia , Neoplasias de Cabeça e Pescoço/patologia , Diagnóstico Diferencial , Linfangioma/patologia , Cisto Dermoide/patologia
9.
Int J Pediatr Otorhinolaryngol ; 138: 110265, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32795730

RESUMO

INTRODUCTION: Pediatric cystic sublingual masses often present a diagnostic dilemma for practitioners. Though uncommon, dermoid or epidermoid cysts can present in the sublingual space at any age and are often misdiagnosed as an inflammatory pseudocyst (ranula) or lymphatic malformation. Imaging may not always identify the underlying etiology, requiring physicians to maintain a high index of suspicion for these relatively rare oral cysts. OBJECTIVES: To describe the presentation and treatment of sublingual dermoid and epidermoid cysts presenting to a tertiary children's hospital over 20 years. METHODS: A retrospective review of all pathology specimens identified as dermoid or epidermoid cysts within the sublingual space from 1999 to 2019. Patient charts were then reviewed for relevant clinical, imaging, and operative data. RESULTS: Twelve pediatric patients were identified (8 female, 4 male) with a mean age of 7.2 years (SD 5.6). Eighty six percent (6/7) of dermoid cysts were found in female patients, while 60% (3/5) of epidermoid cysts were in male patients. Multiple dermoid and epidermoid cysts were each found in one patient (8%). Two epidermoid cysts presented in the neonatal period. Preoperative diagnosis included nondiagnostic "cystic mass" (33%), ranula (25%), lymphatic malformation (LM) (17%), and dermoid/epidermoid cyst (17%). Two thirds of patients (8/12) underwent imaging, with all receiving either MRI or CT. Although MRI was the most likely to suggest the possibility of a dermoid/epidermoid cyst (2/4), ranula was the most common primary radiographic diagnosis (5/8). One patient underwent sclerotherapy for presumed LM one year prior to surgical excision of the cyst. Eleven patients (92%) underwent intraoral excision, one (8.3%) underwent a combined intraoral/extraoral approach. CONCLUSIONS: To our knowledge, this review represents the largest case series of pediatric sublingual dermoid and epidermoid cysts to date. This series contained higher levels of epidermoid cysts and female patients than previously reported in the literature. Identifying more dermoid cysts in females and epidermoid cysts in males is also a new finding. MRI was superior to CT and US regarding the presence of a dermoid/epidermoid cyst. Frequently misdiagnosed, it is important to consider these relatively rare pathologies when treating children presenting with sublingual masses in order to avoid delayed and/or inappropriate treatment.


Assuntos
Cisto Dermoide/diagnóstico , Cisto Dermoide/cirurgia , Cisto Epidérmico/diagnóstico , Cisto Epidérmico/cirurgia , Doenças da Boca/diagnóstico , Adolescente , Criança , Pré-Escolar , Cisto Dermoide/patologia , Cisto Epidérmico/patologia , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Doenças da Boca/patologia , Doenças da Boca/cirurgia , Soalho Bucal/patologia , Rânula/diagnóstico , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Ultrassonografia
10.
Medicine (Baltimore) ; 99(17): e19389, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32332596

RESUMO

RATIONALE: Thyroglossal duct cyst (TGDC) is the most common congenital anomaly of midline neck masses. A thyroglossal duct cyst is especially difficult to diagnose and is treated differently when it appears in the sublingual area. Here, we report a rare case of TGDC extending to the sublingual space. PATIENT CONCERNS: A 42-year-old female presented with a history of neck swelling in the submental region. DIAGNOSIS: The final pathologic diagnosis was a TGDC. INTERVENTIONS: Sistrunk operation was performed. OUTCOMES: Recurrence of the disease has not been seen for the past year. LESSION: Clinical awareness of the thyroglossal duct cyst in the sublingual area or on the oral floor area is important for an accurate diagnosis and the appropriated management.


Assuntos
Soalho Bucal/patologia , Cisto Tireoglosso/patologia , Adulto , Feminino , Humanos , Soalho Bucal/cirurgia , Cisto Tireoglosso/cirurgia
11.
BMC Oral Health ; 20(1): 5, 2020 01 06.
Artigo em Inglês | MEDLINE | ID: mdl-31906928

RESUMO

BACKGROUND: Head and neck Synovial sarcoma (SS) accounts for 3-10% of all total body SS. It is rare to find it in the oral cavity, especially on the floor of the mouth. CASE PRESENTATION: We present a 44-year-old Chinese male, who had been misdiagnosed as fibroadenoma, with a swelling on the right submandibular region for more than 3 months. The radiology examinations and the pathology results indicate the diagnosis of SS of the floor of the mouth. The patient only had a surgical operation, without radiotherapy and chemotherapy. At the first follow-up, the patient exhibited no clinical or radiographic complications, and the patient was asymptomatic on subsequent visits. CONCLUSIONS: Misdiagnosis results the delay of diagnosis and treatment of SS. Immunohistological analysis might be the most important tool to confirm the diagnosis of SS.


Assuntos
Neoplasias Bucais/patologia , Sarcoma Sinovial/patologia , Adulto , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Metástase Linfática , Masculino , Soalho Bucal/patologia , Neoplasias Bucais/cirurgia , Recidiva Local de Neoplasia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Sarcoma Sinovial/cirurgia , Resultado do Tratamento
12.
Oral Oncol ; 102: 104507, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31896500

RESUMO

OBJECTIVES: To evaluate the oncological safety and reliability of the submental island flap (SIF) technique in patients with pathologically node-negative (pN0) and node-positive (pN+) T1-2 oral squamous cell carcinoma (OSCC) undergoing surgical tumor resection and concurrent SIF reconstruction. PATIENTS AND METHODS: Retrospectively, we reviewed patients with pN0 and pN+ T1-2 OSCC who underwent tumor resection and defect reconstruction with SIF from April 2008 to September 2016, focusing on flap viability, patterns and predictors of locoregional failure, salvage treatments, and oncologic prognosis. RESULTS: Of 160 patients with primary T1-2 OSCC, 33 were pN+ and 127 were pN0. All SIFs beside two were successful (98.75%). During follow-up, 18 patients experienced locoregional tumor relapse, of which 14 were pN0 and four were pN+. The 5-year recurrence-free survival was 88.73% vs. 86.93% for the pN0 and pN+ groups, respectively (p = .847). The pN + patients had poorer prognosis than pN0 patients (5-year overall survival, 66.35% vs. 91.10% respectively [p = .005]; disease-specific survival, 74.87% vs. 91.88% respectively [p = .016]). Multivariate analyses indicated there was no independent predictor for locoregional recurrence, but pN+ was predictive for poor prognosis (p = .03). CONCLUSION: SIF is a reliable flap for the reconstruction of OSCC-related small- and medium-sized soft tissue defect. With careful neck dissection and appropriate postoperative adjuvant treatment, the application of SIF did not increase the risk of locoregional tumor recurrence in patients with pN+ T1-2 OSCC compared with those with pN0 T1-2 OSCC.


Assuntos
Sobrevivência de Enxerto , Neoplasias Bucais/cirurgia , Retalhos Cirúrgicos , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Soalho Bucal/patologia , Soalho Bucal/cirurgia , Neoplasias Bucais/mortalidade , Neoplasias Bucais/patologia , Esvaziamento Cervical/métodos , Recidiva Local de Neoplasia , Prognóstico , Reprodutibilidade dos Testes , Estudos Retrospectivos , Terapia de Salvação , Carcinoma de Células Escamosas de Cabeça e Pescoço/mortalidade , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Retalhos Cirúrgicos/efeitos adversos , Análise de Sobrevida , Neoplasias da Língua/mortalidade , Neoplasias da Língua/patologia , Neoplasias da Língua/cirurgia , Resultado do Tratamento
13.
Head Neck Pathol ; 14(1): 199-202, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30758759

RESUMO

We report on a case in which a blanching, unobtrusive oral growth proved to be a systemic threat. A blind, epileptic child presented with a bleeding oral floor mass of 4 weeks. Biopsy showed small, dilated vascular spaces with reactive fibroblasts. MRI indicated distribution of expansile lesions in the mandible, cranial base, and right orbit that had possibly contributed to the patient's years-long neurologic deficits. A subsequent bone scan indicated lesions in multiple axial bones. Histologic markers confirmed the presentation of a rare cystic vascular pathology. Cystic Angiomatosis is a disease of intraosseous vascular malformations with occasional visceral involvements. Oral and craniomaxillofacial cases are especially rare and presentations can involve neuropsychiatric deficits, sensory issues, and mucosal bleeding. While clinicians are often dismissive of intraoral bleeding because of the prevalence of periodontal disease, careful evaluation is nonetheless critical to rule out underlying diseases with a possibly significant systemic involvement.


Assuntos
Osteólise Essencial/patologia , Adolescente , Humanos , Masculino , Soalho Bucal/patologia
15.
J Appl Oral Sci ; 28: e20190198, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31800876

RESUMO

other: Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. OBJECTIVE: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). METHODOLOGY: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). RESULTS: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. CONCLUSION: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.


Assuntos
Carcinoma de Células Escamosas/patologia , Soalho Bucal/patologia , Neoplasias Bucais/patologia , Neoplasias da Língua/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/cirurgia , Intervalo Livre de Doença , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/mortalidade , Neoplasias Bucais/cirurgia , Esvaziamento Cervical/métodos , Gradação de Tumores/métodos , Estadiamento de Neoplasias , Análise de Regressão , Fatores de Tempo , Neoplasias da Língua/mortalidade , Neoplasias da Língua/cirurgia , Adulto Jovem
16.
J. appl. oral sci ; 28: e20190198, 2020. tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1056596

RESUMO

Abstract Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma. Objective: The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC). Methodology: In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005). Results: Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS. Conclusion: Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Bucais/patologia , Neoplasias da Língua/patologia , Carcinoma de Células Escamosas/patologia , Soalho Bucal/patologia , Esvaziamento Cervical/métodos , Fatores de Tempo , Neoplasias Bucais/cirurgia , Neoplasias Bucais/mortalidade , Neoplasias da Língua/cirurgia , Neoplasias da Língua/mortalidade , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/mortalidade , Análise de Regressão , Intervalo Livre de Doença , Estimativa de Kaplan-Meier , Gradação de Tumores/métodos , Estadiamento de Neoplasias
17.
Cir. plást. ibero-latinoam ; 45(3): 323-326, jul.-sept. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-184409

RESUMO

El fibroma osificante es una neoplasia osteogénica benigna que representa el 3.1% de los tumores orales y el 9.6% de las lesiones gingivales. Su tratamiento de elección es la enucleación por curetaje completado hasta márgenes de hueso sano, con una recurrencia de aproximadamente el 7-20% probablemente por remoción incompleta, irritación continua o daño repetido. Presentamos un caso clínico en el que complementamos el tratamiento quirúrgico con métodos adyuvantes para disminuir la recurrencia y acelerar la regeneración ósea mediante uso de nitrógeno líquido y hueso liofilizado cadavérico combinados con plasma rico en plaquetas. En el control postoperatorio a los 6 meses no evidenciamos recurrencia clínica o radiológica y comprobamos regeneración ósea acelerada. Sugerimos el uso en este tipo de lesiones de nitrógeno líquido como adyuvante para la prevención de recurrencia, hueso liofilizado para favorecer la regeneración ósea guiada y plasma rico en plaquetas para acelerar el proceso de curación ósea


Ossifying fibroma is a benign osteogenic neoplasm, representing 3.1% of oral tumors and 9.6% of gingival lesions. Enucleation by curettage is the treatment of choice, completed to healthy bone margins, with a recurrence of approximately 7-20%, probably due to incomplete removal, continued irritation or repeated damage. We describe a clinical case ttreated in combination with adjuvant methods to decrease recurrence and accelerate bone regeneration, with the placement of liquid nitrogen and cadaveric lyophilized bone, combined with platelet-rich plasma. Post-operative control at 6 months showed no clinical or radiological evidence of recurrence and the presence of accelerated bone regeneration. We suggest liquid nitrogen as an adjuvant for the prevention of recurrence and bone regeneration guided with lyophilized bone in conjunction with platelet-rich plasma as a feasible option to accelerate the bone healing process


Assuntos
Humanos , Feminino , Adulto , Fibroma Ossificante/diagnóstico por imagem , Fibroma Ossificante/cirurgia , Terapia Combinada , Neoplasias Gengivais/diagnóstico por imagem , Neoplasias Gengivais/terapia , Retalhos Cirúrgicos , Neoplasias Bucais/diagnóstico por imagem , Neoplasias Bucais/terapia , Biópsia/métodos , Soalho Bucal/patologia , Regeneração Óssea
18.
Rev. esp. cir. oral maxilofac ; 41(3): 149-152, jul.-sept. 2019. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-191779

RESUMO

This article presents the case report of a giant lateral dermoid cyst in the floor of mouth surgically excised by intraoral approach, initially misdiagnosed by imaging studies as a ranula. Other cases of dermoid cysts preoperatively diagnosed ranulae are present in literature, but none directly compares their clinical, radiological and therapeutic aspects. This article will also discuss these aspects in order to possibly aid in their correct diagnosis and management


Este artículo presenta el caso clínico de un gran quiste dermoide lateral en el suelo de la boca, extirpado quirúrgicamente por abordaje intraoral, inicialmente diagnosticado erróneamente por estudios de imagen como una ránula. Otros casos de quistes dermoides diagnosticados preoperatoriamente como una ránula están presentes en la literatura, pero ninguno compara directamente sus aspectos clínicos, radiológicos y terapéuticos. Este artículo también tratará estos aspectos para, posiblemente, ayudarles en su diagnóstico y manejo correctos


Assuntos
Humanos , Masculino , Adolescente , Cisto Dermoide/patologia , Soalho Bucal/patologia , Neoplasias Bucais/patologia , Rânula/patologia , Diagnóstico Diferencial , Cisto Dermoide/cirurgia
19.
Anticancer Res ; 39(5): 2527-2533, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31092449

RESUMO

BACKGROUND/AIM: We evaluated survival rates in surgically-treated oral and oropharyngeal squamous cell carcinoma patients at our clinic, and determined whether survival differed by tumour locations. PATIENTS AND METHODS: In a retrospective study, tumour lesions in 1,486 patients were categorized into 6 groups according to tumour location. Patients' age, sex, tumour-node-metastasis classification, resection status, 5-year and disease-specific survival rates were statistically analysed between groups. RESULTS: A significantly inferior disease-specific and lower 5-year survival rates for tumours located at the base of the tongue and oropharynx, and maxilla, due to higher T-stage and incomplete resection status were shown. Cervical lymph node metastasis and distant metastatic spread were more frequently observed with base of the tongue and oropharynx lesions. CONCLUSION: Attentive inspection and precise clinical examinations of specific oral and oropharyngeal regions are crucial for early diagnosis and treatment. Oral and oropharyngeal tumour locations play important roles in disease prognosis.


Assuntos
Neoplasias Bucais/cirurgia , Neoplasias Orofaríngeas/cirurgia , Prognóstico , Carcinoma de Células Escamosas de Cabeça e Pescoço/cirurgia , Adulto , Idoso , Feminino , Humanos , Metástase Linfática/patologia , Masculino , Maxila/patologia , Pessoa de Meia-Idade , Soalho Bucal/patologia , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/patologia , Estadiamento de Neoplasias , Procedimentos Cirúrgicos Bucais , Neoplasias Orofaríngeas/epidemiologia , Neoplasias Orofaríngeas/patologia , Palato/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Taxa de Sobrevida
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