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1.
J Chem Phys ; 151(14): 144101, 2019 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-31615220

RESUMO

Phycobiliprotein is a light-harvesting complex containing linear tetrapyrrole bilin pigments that are responsible for absorption and funneling the sun's energy in cryptophytes algae. In particular, the protein structure determines relative positions and orientations of the pigments and thus controls energy transfer pathways. The present research reveals the impact of molecular vibrations (in the 850-2700 cm-1 region) on excitation energy transfer in phycobiliprotein. The analysis of the excitation energy transfer pathways indicates a possibility of the coherent mechanism of energy transfer (delocalization) in central dihydrobiliverdin pigments and incoherent vibration-assisted energy transfer to peripheral phycocyanobilin pigments at a sub-picosecond time scale. A computational approach that enables modeling the dynamics of the excitation energy transfer with the quantum master equation formalism employing Huang-Rhys factors to describe electronic-vibrational coupling has been developed. The computational methodology has been implemented in PyFREC software.


Assuntos
Transferência de Energia , Ficocianina/química , Biliverdina/análogos & derivados , Biliverdina/química , Criptófitas/química , Modelos Químicos , Ficobilinas/química , Teoria Quântica , Software , Vibração
2.
Zhongguo Zhong Yao Za Zhi ; 44(15): 3135-3142, 2019 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-31602864

RESUMO

This research is launched to look for the medication rules and characteristics of Tibetan medicine in the treatment of gZav-Grib( apoplexy sequelae). HIS records of gZav-Grib patients were selected from the Tibetan Hospital of Tibet Autonomous Region and Tibetan Hospital of the city of Naqu. SPSS Modeler,Gephi and other data mining and visualization software were used to study the actual law of drug use in the treatment of gZav-Grib in Tibetan medicine. Finally,479 cases of gZav-Grib patients in Tibetan medicine were included. Their average age is 63 and average hospital stay was 32 days. In total,82 Tibetan medicine prescriptions were used for treating gZav-Grib. The frequency in the front is Twenty-flavor Chenxiang Pills( 338 times),Ruyi Zhenbao Pills( 322 times),and Seventy-flavor Zhenzhu Pills( 315 times). According to the regularity of Tebitan medicine,they were applied in different time periods including the early morning,morning,noon,and evening,for example,in the early morning: Seventy-flavor Zhenzhu Pills,morning: Ruyi Zhenbao Pills,noon: Eighteen-flavor Dujuan Pills,evening: Twenty-flavor Chenxiang Pills. In the clinical joint,18 groups were found in the 10% support and 70% confidence. There are two prescriptions confidence more than 80% which nature focus on Gan,Ruan,Xi,Liang,Dun,Han,Wen. gZav-Grib of Tibetan medicine can be divided into two types: r Lung-Grib type and k Hrag-Grib type,in which the medicine of r Lung-Grib type takes Seventy-flavor Zhenzhu Pills as the core prescription,while the medicine of k Hrag-Grib type takes Ruyi Zhenbao Pills as the core prescription. It is found that the treatment of gZav-Grib by Tibetan medicine is mainly dominated by the treatment idea about " Therapeutic r Lung and blood,Consideration of venous diseases". Treatment functions is promoting the circulation of Qi,clearing blood heat and getting rid of bad blood,achieving the purpose of treating both principal secondary aspect of gZav-Grib. The research methods based on the HIS can't only optimize the Tibetan treating gZav-Grib sequela treatment plan and rule of medication,but also provide the scientific basis for Tibetan medicine treat gZav-Grib.


Assuntos
Medicina Tradicional Tibetana , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/tratamento farmacológico , Mineração de Dados , Humanos , Registros Médicos , Software , Tibet
3.
Zhongguo Zhong Yao Za Zhi ; 44(15): 3143-3150, 2019 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-31602865

RESUMO

This study aimed to explore the rule of Tibetan medicine in clinical treatment of hypertension( k Hrag-rLung-stod-vtshangs) and analyze the characteristics of its prescriptions. One hundred and thirty-seven cases of hypertension treated Tibetan medicine were collected. Data mining,Gephi,Cytoscape and other methods and software were used to analyze the characteristics of Tibetan medicine. The results showed that there were 44 cases of r Lung-type hypertension in clinical medical records,while 57 cases of k Hrag-type hypertension. There were 103 treatment prescriptions. The frequency of these prescriptions covered Twenty-five Yuganzi Pills( 96 times),Seventy Pearl Pills( 80 times),Eight Chenxiang Pills( 75 times),and Sanwei Ganlu Powder( 62 times),and they were highly correlated,with confidence greater than 95%. There were 332 prescriptions involved in the prescriptions which is core prescription medicines. This study first proposed the dosage analysis method of Tibetan medicine prescription medicines,and obtained the more dosage of Chebulae Fructus,Phyllanthi Fructus,Aucklandiae Radix,Aquilariae Lignum Resinatum and so on. The correlation analysis of the prescription medicines found that Carthami Flos,Myristicae Semen,Bambusae Concretio Silicea,Caryophylli Flos,Amomi Fructus Rotundus led by Tsaoko Fructus had a high correlation and a confidence greater than 75%. These herbs were guaranteed when Tibetan medicine was used in combination. The key drugs for protecting viscera and regulating the three gastric fires. The prescription is mainly cold,blunt,sparse and rough. Its efficacy focuses on the pathogenesis of blood fever,blood stickiness and venous blockage caused by heat,sharpness,odor and stickiness. It mainly treats Tibetan medicine diseases such as k Hrag-r Lung-stod-vtshangs and k Hrag-vpel( polyemia). It is suggested that Tibetan medicine has a three-in-one invisible treatment principle of " clearing blood-heat,opening vessel and regulating stomach-fire" in the treatment of hypertension,which attributed to both cardiovascular function and gastrointestinal metabolic function. This may be a significant and invisible knowledge of Tibetan medicine in the treatment of hypertension.


Assuntos
Hipertensão/tratamento farmacológico , Medicina Tradicional Tibetana , Mineração de Dados , Humanos , Registros Médicos , Software
5.
Rev Lat Am Enfermagem ; 27: e3186, 2019 Oct 14.
Artigo em Português, Inglês, Espanhol | MEDLINE | ID: mdl-31618386

RESUMO

OBJECTIVE: to identify in the scientific literature the technologies developed to promote health education for the community elderly. METHOD: integrative review that included original articles indexed by Latin American and Caribbean Literature in Health Sciences, Medical Literature Analysis and Retrieval System Online, Cumulative Index to Nursing and Allied Health Literature, Scopus, Web of Science, Science Direct, and Cochrane databases, without restriction of time and language. Results were analyzed descriptively, in five analytical categories. RESULTS: Fifteen articles published on national and international journals were selected, with predominance of experimental studies that tested the effects of such technologies. The types of educational technology developed were printed materials, software and video, as well as mock-up and telephone support. Falls in the elderly were the most discussed theme. The studies have shown that the types of technology found are feasible to promote health education for the community elderly. CONCLUSION: The technologies developed to promote health education for the elderly were multiple and proved effective for use in community interventions.


Assuntos
Tecnologia Educacional/métodos , Educação em Saúde/métodos , Promoção da Saúde/métodos , Acidentes por Quedas/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Recursos Audiovisuais , Humanos , Educação de Pacientes como Assunto/métodos , Software
7.
Wei Sheng Yan Jiu ; 48(4): 659-663, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31601355

RESUMO

OBJECTIVE: To promote the application of air pollution health risk assessment software BenMAP-CE developed by the US Environmental Protection Agency in China's air pollution health risk assessment. METHODS: According to China's air quality and health impact monitoring data characteristics, the software's operational analysis process and principle, scope of application, required data, export and import settings and application examples are systematically introduced. RESULTS: Through the software, the parameters of the research area of China can be input into the module, and the health benefit analysis can be carried out according to the change of air quality. CONCLUSION: The software is suitable for China's air pollution health risk assessment, and has guiding significance and reference value for the formulation of environmental policies.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Software , China , Monitoramento Ambiental , Medição de Risco
8.
Arch Esp Urol ; 72(8): 794-803, 2019 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-31579038

RESUMO

Transrectal ultrasound has been a diagnostic method for diagnosis of prostate cancer for more than 30 years. It increased its options after the incorporation of MRI in the 90s. The association of real-time ultrasound with anatomical and functional data of multiparametric magnetic resonance imaging (mpMRI) has changed the prostate cancer scenario and presumably will modify the therapeutic alternatives. OBJECTIVES AND METHODS: In the following non systematic review of the literature, we present the current situation of different types of fusion biopsy, the initial preclinical and clinical results as well as the data collected in the different meta-analyses. RESULTS: Although "in bore" biopsy has shown the best sensitivity, its economic and accessibility problems make it the least widespread. Cognitive biopsy is one of the most widespread despite being the one that provides the least objective results. Fusion biopsies with Software Platform are being developed as the most reproducible and affordable in our environment. The data in the literature is still insufficient to establish what is the best software. There are many points of controversy such as number of cores, approach, associated systematic biopsies and possible connotations when assessing the therapeutic attitude. CONCLUSION: None of the Software platforms have demonstrated superiority in the diagnosis of cancer, although their results are superior to those obtained through standard and cognitive biopsy and are more affordable than the "In bore" biopsy. It is necessary to standardize the publications to be able to compare results (classification of risk in resonance, number of cores, approach). The diagnosis of cancer guided by MRI should be a factor to consider in therapeutic decision nomograms. The next challenge is the incorporation of these systems in the protocols of active surveillance and Focal Therapy.


Assuntos
Biópsia Guiada por Imagem , Neoplasias da Próstata , Software , Humanos , Imagem por Ressonância Magnética , Masculino , Neoplasias da Próstata/diagnóstico , Ultrassonografia
9.
Biochem Med (Zagreb) ; 29(3): 030710, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31624463

RESUMO

Introduction: Moving average (MA) means calculating the average value from a set of patient results and further using that value for analytical quality control purposes. The aim of this study was to examine whether the selection, optimization and validation of MA procedures can be performed using the already described bias detection simulation method and whether it is possible to select appropriate MA procedures for a laboratory with a small daily testing volume. Materials and methods: The study was done on four analytes: creatinine, potassium, sodium and albumin. All patient results of these tests processed during six months were taken from the laboratory information system. Using the MA Generator software, different MA procedures were analysed. Different inclusion criteria, calculation formulas, batch sizes and weighting factors were tested. Selection of optimal MA procedures was based on their ability to detect simulated biases of different sizes. After optimization, the validation of MA procedures was done. The results were presented by bias detection curves and MA validation charts. Results: Simple MA procedures for albumin and sodium without truncation limits were selected as optimal. Exponentially weighted MA procedures were found optimal for creatinine and potassium, with the upper truncation limits of 150 µmol/L and 6 mmol/L, respectively. Conclusions: It has been experimentally confirmed that it is possible to perform the selection, optimization and validation of MA procedures using the bias detection simulation method. Also, it is possible to define MA procedures optimal for a laboratory with a small daily testing volume.


Assuntos
Laboratórios/normas , Humanos , Controle de Qualidade , Software
10.
Int J Prosthodont ; 32(6): 541-543, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31664272

RESUMO

PURPOSE: To evaluate the accuracy of a smartphone application as a low-cost approach for digitizing a facial defect for 3D modeling. MATERIALS AND METHODS: A stone model of a facial defect was scanned using industrial computed tomography (reference scan) and was also scanned five times using a commercial laser scanner. A series of 24 sequenced digital photographs was taken five times by smartphone at two elevations. These images were uploaded and processed by a cloud-based server to create virtual 3D models. The 3D datasets were geometrically evaluated and compared to the reference data using 3D evaluation software. Mann-Whitney U test was used for statistical analysis, and the significance was set at P < .05. RESULTS: The overall mean 3D deviation ± standard deviation for the smartphone dataset was 604.9 ± 123.5 µm compared to 67.5 ± 0.49 µm for the laser scanner. There was a significant difference in the accuracy between the commercial laser scanner and the smartphone application (P = .009). CONCLUSION: The results showed that within the limits of this study and in reference to standard computed tomography imaging, data acquisition with a smartphone for 3D modeling is not as accurate as commercially available laser scanning.


Assuntos
Smartphone , Projeto Auxiliado por Computador , Face , Imagem Tridimensional , Software
11.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 36(5): 810-817, 2019 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-31631630

RESUMO

As a complex system, the topology of human's brain network has an important effect on further study of brain's structural and functional mechanism. Graph theory, a kind of sophisticated analytic strategies, is widely used for analyzing complex brain networks effectively and comparing difference of topological structure alteration in normal development and pathological condition. For the purpose of using this analysis methodology efficiently, it is necessary to develop graph-based visualization software. Thus, we developed VisConnectome, which displays analysis results of the brain network friendly and intuitively. It provides an original graphical user interface (GUI) including the tool window, tool bar and innovative double slider filter, brain region bar, runs in any Windows operating system and doesn't rely on any platform such as Matlab. When importing the user-defined script file that initializes the brain network, VisConnectome abstracts the brain network to the ball-and-stick model and render it. VisConnectome allows a series of visual operations, such as identifying nodes and connection, modifying properties of nodes and connection such as color and size with the color palette and size double slider, imaging the brain regions, filtering the brain network according to its size property in a specific domain as simplification and blending with the brain surface as a context of the brain network. Through experiment and analysis, we conclude that VisConnectome is an effective visualization software with high speed and quality, which helps researchers to visualize and compare the structural and functional brain networks flexibly.


Assuntos
Encéfalo/fisiologia , Conectoma , Software , Humanos
12.
Stud Health Technol Inform ; 267: 66-73, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483256

RESUMO

Data integration is the problem of combining data residing at different sources and providing the user with a unified view of these data. In medical informatics, such a unified view enables retrospective analyses based on more facts and prospective recruitment of more patients than any single data collection by itself. The technical part of data integration is based on rules interpreted by software. These rules define how to perform the translation of source database schemata into the target database schema. Translation rules are formulated by data managers who usually do not have the knowledge about meaning and acquisition methods of the data they handle. The professionals (data providers) collecting the source data who have the respective knowledge again usually have no sufficient technical background. Since data providers are neither able to formulate the transformation rules themselves nor able to validate them, the whole process is fault-prone. Additionally, in continuous development and maintenance of (meta-) data repositories, data structures underlie changes, which may lead to outdated transformation rules. We did not find any technical solution, which enables data providers to formulate transformation rules themselves or which provides an understandable reflection of given rules. Our approach is to enable data providers understand the rules regarding their own data by presenting rules and available context visually. Context information is fetched from a metadata repository. In this paper, we propose a software tool that builds on existing data integration infrastructures. The tool provides a visually supported validation routine for data integration rules. In a first step towards its evaluation, we implement the tool into the DZL data integration process and verify the correct presentation of transformation rules.


Assuntos
Metadados , Semântica , Software , Bases de Dados Factuais , Humanos , Estudos Prospectivos , Estudos Retrospectivos
13.
Stud Health Technol Inform ; 267: 110-117, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483262

RESUMO

In the life science domain, experts are usually familiar with spreadsheet software and often use it in their daily work to collect and structure required domain knowledge. The processing and analysis of spreadsheet data is an important task that must be supported by efficient software solutions. A typical application scenario is for example an integration of spreadsheet data (specified or derived) in an ontology to provide reasoning or search. Different converter tools were developed to support a spreadsheet-to-ontology transformation. Such tools allow often only a relatively simple structure of the spreadsheet template or they require complex mapping processes to map the spreadsheet and ontological entities. In many cases, it is impossible to use the existing converter tools because the spreadsheet data must be processed first before the derived data can be integrated into the ontology. In such cases, an efficient and fast development of customized software solutions is of great importance. In this paper, we present a general spreadsheet processing framework to efficiently read and write spreadsheet data. The Spreadsheet Model Generator (SMOG) provides a simple mechanism to automatically generate the Java object model and mappings between object code and spreadsheet entities. Our solution greatly simplifies the implementation of spreadsheet access methods and enables an efficient development of spreadsheet-based applications. The SMOG has already been used successfully in several biomedical projects under real world conditions.


Assuntos
Software
14.
Stud Health Technol Inform ; 267: 118-125, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483263

RESUMO

Computerized guidelines have been utilized for several decades by now. Systems based on computerized-guidelines often intertwine (1) medical knowledge representation, (2) guideline procedures and (3) hospital workflows. This induces several drawbacks. Most prominent problems include non-shareability of the computerized guideline between hospitals, limited accessibility of the computerized guideline for humans, and an unclear, often confusing combination of hospital-specific workflow and guideline-induced control flows. This article proposes a 3-layer modelling approach strictly distinguishing the aforementioned three aspects to overcome the respective problems. We applied the 3-layer approach to the implementation of a guideline-interpreting software module in the context of the Medical Informatics Initiative Germany (here: SMITH Project) and comment on the resulting implications for the software design of that module.


Assuntos
Informática Médica , Alemanha , Guias de Prática Clínica como Assunto , Software , Desenho de Programas de Computador , Fluxo de Trabalho
15.
Stud Health Technol Inform ; 267: 134-141, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483265

RESUMO

We developed a tool based on the KNIME analytics platform for the extraction and visualisation of medical time series stored in the Medical Information Mart for Intensive Care III (MIMIC III) and the related MIMIC-III Waveform Database Matched Subset. The large number of data points and the free accessibility make these data sets an attractive source for data-driven projects in the medical domain. The problem that we tackled with our tool was the lack of an easy and extensible way of selecting, reading, and visualising stored time series. Especially the fact that medical data science projects are often conducted by interdisciplinary teams called for a software solution that can be utilised by medical practitioners without programming experiences and that still offers enough flexibility for data scientists.


Assuntos
Bases de Dados Factuais , Software , Cuidados Críticos , Humanos
16.
Stud Health Technol Inform ; 267: 142-149, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483266

RESUMO

Translational research in the medical sector is dependent on clear communication between all participants. Visualization helps to represent data from different sources in a comprehensible way across disciplines. Existing tools for clinical data management are usually monolithic and technically challenging to set up, others require a transformation into specific data models while providing mostly non-interactive visualizations or being specialized to very particular use cases. Statistical programming languages (R, Julia) on the other hand offer great flexibility in data analytics, but are harder to access for clinicians with little to no programming expertise. Our software, the Medical Data Explorer (MedEx), aims to fill this gap as light-weight, intuitive, web-based solution with simple data import routes. We couple a modern dynamic web interface with an in-memory database solution for near real-time responsiveness. MedEx provides multiple visualization options (Scatterplot, correlation heatmap, bar chart, grouped boxplot, grouped histogram, coplot) to get an easy overview on the loaded data as well as to perform pattern discovery and elementary statistics. We demonstrate the utility of MedEx, by example, on data from the cardiology research warehouse of Heidelberg University Hospital. In summary, our tool empowers clinicians to conduct their own interactive exploratory data analysis.


Assuntos
Software , Ciência de Dados , Linguagens de Programação , Interface Usuário-Computador
17.
Stud Health Technol Inform ; 267: 262-269, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483281

RESUMO

Antimycotics are substances to treat fungal infections, a frequent cause of death on intensive care units. It is of great importance to administer such drugs only to patients who actually need them, since the unnecessary application leads to the selection of multiresistent fungi, making future therapy more difficult, and represents a significant financial burden for the health care system. Within the scope of a prospective study, which analyses the premature discontinuation of the administration of unnecessary antifungal drugs, two software platforms for recruitment support were implemented and compared at the University Hospital Erlangen. Besides technical aspects, such as the necessary development time and query runtimes, their usability and user friendliness for the clinical users were compared. We found that the practical identification of patient cohorts is possible both with a full featured business intelligence application and with a low effort approach based on language constructs of the Arden Syntax. Furthermore, this pilot evaluation led to important insights related to the clinical documentation context and data quality issues. A comprehensive analysis of the clinical environment and documentation context is essential for the final decision on the tool to be used.


Assuntos
Unidades de Terapia Intensiva , Seleção de Pacientes , Software , Eletrônica , Humanos , Estudos Prospectivos
18.
Zhonghua Yu Fang Yi Xue Za Zhi ; 53(9): 955-960, 2019 Sep 06.
Artigo em Chinês | MEDLINE | ID: mdl-31474082

RESUMO

Logistic regression is a kind of multiple regression method to analyze the relationship between a binary outcome or categorical outcome and multiple influencing factors, including multiple logistic regression, conditional logistic regression, polytomous logistic regression, ordinal logistic regression and adjacent categorical logistic regression. This paper illustrates the basic principle, independent variable selection and assignment, applied condition, model evaluation and diagnosis for multiple logistic regression model. Moreover, the principle and application for polytomous logistic regression and ordinal logistic regression models were also introduced. By providing SAS codes and detailed explanations of the result for an example of obesity, readers could be able to better understand logistic regression model, and apply this method correctly to their research and daily work, so as to improve their capacity of the data analysis.


Assuntos
Interpretação Estatística de Dados , Modelos Logísticos , Humanos , Obesidade , Software
19.
Zhonghua Shao Shang Za Zhi ; 35(8): 622-623, 2019 Aug 20.
Artigo em Chinês | MEDLINE | ID: mdl-31474047

RESUMO

We used Excel program to compile nutrition calculation program. A nutrition database for daily diet of patients with critical burns is established based on data sources of Chinese food composition table (2002 edition) , Chinese food culture academic symposium collection and common food nutrition table of the sports nutrition research center of Sports Medical Research Institute of General Administration of Sports of China, and label values of nutrition components of packaged food. According to the proportion of food net content, the formulas are adopted for calculating the dietary nutrition composition of patients with critical burns. An electronic scale is used to weigh the quality of food ingested through the mouth and gastric tube. After recording the weight into Excel scale, the value of nutrition content in patients' diet can be quickly and accurately generated automatically. It is convenient to calculate the water intake and output, which can quickly and accurately provide the dietary status assessment for patients with critical burns. It can not only calculate the total energy and water intake amount, but also calculate the daily protein intake and proportions of the three major nutrients in energy supply. Therefore, it provides a credible basis for further strengthening and improving nutritional support.


Assuntos
Queimaduras/terapia , Apoio Nutricional , Peso Corporal , China , Dieta , Humanos , Software
20.
Bioresour Technol ; 293: 122103, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31505391

RESUMO

Efficient quantification of interfacial energy related with membrane fouling represents the primary interest in membrane bioreactors (MBRs) as interfacial energy determines foulant layer formation. In this study, radial basis function (RBF) artificial neural networks (ANNs) with five related factors as input variables were applied to quantify interfacial energy with randomly rough membrane surface. It was found that, RBF ANNs could well capture the complex non-linear relationships between the related factors and interfacial energy. RBF ANN quantification showed high regression coefficient and accuracy, suggesting its high capacity to quantify interfacial energy. Compared to at least one-week time consumption of the advanced extensive Derjaguin-Landau-Verwey-Overbeek (XDLVO) approach, quantification by RBF ANNs only took several seconds for a same case, indicating the high efficiency of RBF ANNs. Moreover, the abilities of RBF ANNs can be further improved. The robust RBF ANNs proposed paved a new way to study membrane fouling in MBRs.


Assuntos
Reatores Biológicos , Membranas Artificiais , Redes Neurais (Computação) , Fenômenos Físicos , Software
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