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1.
Medicine (Baltimore) ; 98(46): e17642, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31725607

RESUMO

The sleep allows many psychological processes, such as immune system activity, body metabolism and hormonal balance, emotional and mental health, learning, mnemonic processes. The lack of sleep could undermine mental and physical purposes, causing an alteration in cognitive functions or metabolic disorders. In our study, we have examined the irregular sleep effects with the overweight and obesity risk in children and adults.The sample was composed of 199 subjects, of which 71 adults, (29 males and 42 females), and 128 children (73 males and 55 females). We have measured the weight and height with standard techniques; we also have measured the body mass index dividing the weight in kg with the height square expressed in meters (kg/m). Subjects were divided into underweight, normal weight, overweight, and obese. Were administered some questionnaires to measure the quantity and quality of sleep, and eating habits and individual consumption of food.Analysis of demographic variables not showed significant differences between male and female groups but highlighted a significant trend differences in normal-weight score. The clinical condition has a substantial impact on body mass index score and sleep hours were significant predictor on this.Quantity and quality sleep can also represent a risk factor of overweight and obesity, so sufficient sleep is a factor that influence a normal weight. Adults and children that sleep less, have an increase in obesity and overweight risk with dysfunctional eating behaviors, decreased physical activity, and metabolic changes.


Assuntos
Obesidade/fisiopatologia , Sobrepeso/fisiopatologia , Transtornos do Sono-Vigília/fisiopatologia , Sono/fisiologia , Magreza/fisiopatologia , Adulto , Índice de Massa Corporal , Criança , Comportamento Alimentar , Feminino , Humanos , Masculino , Obesidade/complicações , Sobrepeso/complicações , Fatores de Risco , Transtornos do Sono-Vigília/complicações , Inquéritos e Questionários , Magreza/complicações
2.
Rev Prat ; 69(5): 537-545, 2019 May.
Artigo em Francês | MEDLINE | ID: mdl-31626464

RESUMO

Sleep is a physiological condition essential to life, present in all living organisms with a neuronal and glial network. Its functions, not fully understood, include the conservation of energy, the regulation of our immune system and brain function through the modulation of synaptic plasticity and the elimination of substances accumulated during wakefulness. Sleep in human is characterized by two exclusive states, the non-REM and the REM -paradoxical- sleep, whose occurrence is driven by a cyclic organi zation. Sleep and wakefulness result from complex mechanisms involving a hetero geneous transition of different brain structures from one physiological state to another. The sleep duration and distribution of sleep over 24 hours are regulated by complex interconnected mechanisms, involving both the need for sleep accumulated during wakefulness -homeostatic process- and biological rhythm -mainly the circadian process- under the influence of external synchronizers like light-dark cycle. The propensity to sleep at a given moment is regulated by a physiological signal, sleepiness, in connection with the level of vigilance. The characteristics of sleep are relatively stable for a given individual because of a strong genetic determinism, but varies in duration and architecture according to age, individual habits, sleep schedules and environmental constraints. An understanding of the physiology of sleep is important for the clinician, allowing a better understanding of sleep dysfunction, responsible for various and frequent sleep disorders equiring appropriate care.


Assuntos
Transtornos do Sono-Vigília , Sono , Ritmo Circadiano/fisiologia , Homeostase , Humanos , Sono/fisiologia , Sono REM/fisiologia , Vigília/fisiologia
3.
Medicina (B Aires) ; 79 Suppl 3: 25-28, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31603839

RESUMO

Sleep is an active and cyclic physiological process that has a critical impact on health. Its functions are numerous: growth, development, learning, memory, synaptic efficiency, regulation of behavior, emotion, immune strengthening and cleaning time of neurotoxic substances. During the first years of life, there are a number of important changes in development, which lead to the expected pattern of sleep and wakefulness in adults. The sleep occupies a third of the adult's life. However, sleeping during the first months of life takes up more than 50% of time. This review of the topic will describe normal sleep patterns in childhood.


Assuntos
Sono/fisiologia , Criança , Humanos , Vigília/fisiologia
4.
Medicina (B Aires) ; 79 Suppl 3: 29-32, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31603840

RESUMO

Recent studies have demonstrated that while we are sleeping, our brain is very busy processing all information we have acquired along the day. Lack of sleep has shown to produce deficits in memory consolidation and plays an important role in brain development and brain plasticity in the several developmental stages of the human brain. At the cellular level, circadian cycles coordinate complex mechanism that "turn on and off" genes and cellular structures regulating individual cell functions to impact global organ and systems physiological activities. At the end a perfect and coordinated equilibrium in the mental, emotional and physiological is the goal of this complex process. Sleep impacts memory, learning, mood, behavior, immunological responses, metabolism, hormone levels, digestive process and many more physiological functions. We present a review of three basic aspects related with sleep: a. brain electrical activity during the sleep and neuroanatomic correlation with mechanism related with memory and learning; b. circadian cycles and impact in several physiological systems; c some examples of clinical disorders associated with sleep disorders and impact in learning and memory.


Assuntos
Ritmo Circadiano/fisiologia , Aprendizagem/fisiologia , Memória/fisiologia , Plasticidade Neuronal/fisiologia , Sono/fisiologia , Encéfalo/fisiologia , Emoções/fisiologia , Humanos , Transtornos do Sono-Vigília/fisiopatologia
5.
Rev Saude Publica ; 53: 82, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31576942

RESUMO

OBJECTIVE: To estimate the prevalence of poor self-rated sleep and to identify the population subgroups most susceptible to the problem. METHODS: This is a cross-sectional, population-based study developed with data from the Health Survey conducted in the city of Campinas (ISACamp 2014/2015). Data from a sample of 1,998 individuals aged 20 years or older were analyzed. The self-rated quality of sleep was analyzed according to socio-demographic characteristics, morbidities, health behaviors and feeling of well-being. The association of sleep quality with different complaints and characteristics of sleep was also analyzed. Adjusted prevalence ratios were estimed using Poisson multiple regression model allowing for the sample weights. RESULTS: Prevalence of poor self-rated sleep was 29.1% and showed to be significantly higher in women, in individuals aged from 40 to 50 years, migrants, without occupation, physically inactive in leisure context, with common mental disorder (PR = 1.59), with greater number of health problems (PR = 2.33), poor self-rated health (PR = 1.61), and life dissatisfaction. Poor sleep was strongly associated with reports of difficulty in initiating sleep (PR = 4.17), in maintaining sleep (PR = 4.40) and with never or almost never feeling well when waking up (PR = 4.52). CONCLUSIONS: The results identify the population subgroups with poor quality of sleep that deserve greater attention. It also highlight the need to consider, in addition to the presence of comorbidities, mental health and the feeling of well-being in the care of patients with sleep problems and in the interventions planed for promoting healthy sleep.


Assuntos
Qualidade de Vida , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/fisiopatologia , Sono/fisiologia , Adulto , Brasil/epidemiologia , Estudos Transversais , Feminino , Comportamentos Relacionados com a Saúde , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Autoimagem , Fatores Sexuais , Fatores Socioeconômicos , Inquéritos e Questionários , Adulto Jovem
6.
Ideggyogy Sz ; 72(9-10): 304-314, 2019 Sep 30.
Artigo em Húngaro | MEDLINE | ID: mdl-31625697

RESUMO

Aims - Overview of the new data about the strong link of sleep and epilepsy and conjoining cognitive impairment. Methods - Search for relevant references and summary of our own research activity on the topic. Results - Strong interrealtionship exists between epilepsy and plastic brain functions (memory processing and synaptic homeostasis) and the working modes of NREM sleep. In the most frequent childhood and adult epilepsy networks responsible for plastic functions can be derailed to an epileptic level of excitability, and suffer a transitory or permanent epileptic transformation. Exampling on the three big epilepsies: absence epilepsy; medial temporal lobe epilepsy; and childhood idiopathic focal age dependent epilepsy spectrum we demonstrate the most important features of this epileptic transformation. The association of cognitive impairment to certain sleep dependent epilepsies gains explanation by the epilepsy caused interference with slow wave decline (ICFE) and memory consolidation (MTLE) during NREM sleep. This paper serves also to introduce the concept of sleep dependent system epilepsies. Conclusions - We provide evidences about shared mechanisms among sleep related epilepsies being the derailment of sleep plastic funcions toward exaggerated excitability determined by the inherent possibilities of the signal transduction properties.


Assuntos
Disfunção Cognitiva/fisiopatologia , Epilepsias Parciais/fisiopatologia , Epilepsia/fisiopatologia , Sono/fisiologia , Adulto , Criança , Eletroencefalografia , Humanos , Plásticos , Fases do Sono/fisiologia
7.
Ideggyogy Sz ; 72(7-8): 236-240, 2019 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-31517455

RESUMO

Introduction - Restless Leg Syndrome (RLS) is a disease, primarily composed of sensational symptoms, caused by the urge to move lower extremities especially at night, and characterized by undesired feelings of the legs. Decreasing of the dopaminergic effect at night is thought to be responsible from these symptoms. RLS patients suffer from low quality of sleep affecting their daily life activities even causing socio-economic loss. Although RLS is a common and treatable disease, it can not be diagnosed easily due to the variability of symptoms. Aim - The purpose of this study is to determine the frequency of RLS among health workers and to define the disease causing factors. Method - A questionnaire was applied to 174 randomly selected health workers at Baskent University Medical Faculty (KA17/285). The demographic information, history of illnesses or usage of drugs, socioeconomic status, working hours and daytime sleepiness were questioned. Included in the questionnaire were diagnostic criteria for RLS, frequency assessment scale, and survey of sleep quality. We used "the diagnostic criteria of international RLS working group" for the diagnosis, and "Pittsburgh sleep quality index survey" to determine the quality of sleep. Reliability and validity studies were performed on both tests. Results - A significant relationship between socio-economic status and RLS was found (p<0.05) as an increase of RLS frequency in parallel with decreased socio-economic status. RLS was found to be common among health workers. We suggest that health workers should be checked regularly, and they should be informed about the disease in order to raise an awareness and hence increase their quality of life.


Assuntos
Qualidade de Vida/psicologia , Síndrome das Pernas Inquietas/psicologia , Transtornos do Sono-Vigília/fisiopatologia , Humanos , Reprodutibilidade dos Testes , Síndrome das Pernas Inquietas/epidemiologia , Sono/fisiologia , Inquéritos e Questionários
8.
Ideggyogy Sz ; 72(7-8): 264-272, 2019 Jul 30.
Artigo em Húngaro | MEDLINE | ID: mdl-31517459

RESUMO

Background and purpose: Objective - Our aim is to evaluate sleep habits, sleep quality and influencing factors among preschool- and schoolchildren. Methods: Two questionnaires were recorded. Questionnaire 1 dealt with sleeping habits, breastfeeding and health behavior of preschool children and infant, and it contained the abbreviated version of the Children's Sleep Habits Questionnaire. Questionnaire 2 dealt with health behavior and the application of sleep hygiene rules, as well as it contained the Athens Insomnia Scale. Subjects - We assessed a total of 1063 questionnaires: 516 kindergarten children participated in our online survey across the country; 547 primary and secondary school students participated in the 2nd questionnaire survey in Szolnok. Results: Parents' observation shows that the average nighttime sleeping time of kindergarten children is 10 hours 20 minutes on weekdays and 10 hours 36 minutes on weekends. The most popular sleeping habits in kindergarten age: teal reading (65.1%) and co-sleeping (42.8%). Parents of infants used breastfeeding (50.4%) and rocking (43.2%) most frequently before sleep. Co-sleeping has a positive influence on the length of lactation. Among the preschool sleeping habits we have proved a number of positive effects of teal reading, while watching television have negative effects. The sleep quality of school-age children according to the Athens Insomnia Scale is 6.11 points (SD: 4.11), 19% of the children are insomniac. Their sleep time is 7 hours 31 minutes on weekdays and 9 hours 30 minutes on weekends. The usage of good health behavior and sleep hygiene rules positively influence sleep quality and sleep duration. Conclusion: With our results, we would like to draw the attention of children and parents to the importance of sleeping and using sleep hygiene rules.


Assuntos
Hábitos , Comportamentos Relacionados com a Saúde , Higiene do Sono , Sono/fisiologia , Televisão , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Iluminação , Masculino , Instituições Acadêmicas , Inquéritos e Questionários
9.
Niger J Clin Pract ; 22(9): 1218-1223, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31489857

RESUMO

Aim: This study aimed to determine the sleeping habits and sleeping periods of kindergarten children, in order to analyze the problems related to sleep hygiene and determine the underlying factors. Methods: The sample size of this cross-sectional study consisted of 390 children. A questionnaire filled in by the parents was used as the data collection tool. The data were analyzed with appropriate statistical tests. Results: According to the mothers, 77.2% of the children had their own room at home. Thirty nine percent of children slept with the full light on in their room, 50.3% slept with night light on in their room, 12.3% slept with the radio/television on in their room. Infant sleep practices found in this study are swaddling (18.5%), wrapping of the infant's arms (21.0%), and rocking (58.7%). Conclusions: In terms of sleep hygiene, the vast majority of the children slept in a bright environment, and there were electronic appliances in the room. Common infant-transition-to-sleep practices observed were wrapping their arms and swaddling them. In our point of view, awareness training for parents about the subject will support sleep hygiene practices.


Assuntos
Hábitos , Transtornos do Sono-Vigília/prevenção & controle , Sono/fisiologia , Criança , Saúde da Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Mães , Pais , Instituições Acadêmicas , Transtornos do Sono-Vigília/epidemiologia , Inquéritos e Questionários
11.
Postgrad Med ; 131(7): 479-485, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31513436

RESUMO

Objectives: To evaluate clinical, electrophysiological, and neuroradiological factors which correlate with the prognosis in patients with mesial temporal lobe epilepsy (MTLE). Methods: This was a single-center prospective outcome study in patients with MTLE. The patients' family history, clinical characteristics, neurophysiological data (electroencephalography - EEG), neuroimaging, antiepileptic therapy, and outcome were collected and analyzed. The population was divided into four groups depending on the frequency of the seizures when they attended their last follow up. All variables and outcome measures were compared between the four groups. Results: In total 83 consecutive patients were included within the four groups. Group 1 (seizure-free) consisted of 7 patients, (9%), Group 2 (rare seizures) consisted of 15 patients (18%), Group 3 (often seizures) consisted of 30 patients (36%), and Group 4 (very often seizures) consisted of 31 patients (37%). The groups did not differ significantly in demographic characteristics. There was a strong positive correlation between resistance to therapy and sleep activation on EEG (p = 0.005), occurrence of focal to bilateral seizures (p = 0.007), automatisms (p = 0.004), and the number of previously used antiepileptic drugs (AEDs) (p = 0.002). There was no association between febrile convulsions (FC), hippocampal sclerosis (HS), and the outcome that was found. Conclusion: MTLE is a heterogeneous syndrome. Establishing the factors responsible for, and associated with, drug resistance is important for optimal management and treatment, as early identification of drug resistance should then ensure a timely referral for surgical treatment is made. This prospective study shows that sleep activation on EEG, ictal automatisms, occurrence of focal to bilateral tonic-clonic seizures, and increased number of tried AEDs are negative prognostic factors.


Assuntos
Automatismo/fisiopatologia , Epilepsia Resistente a Medicamentos/fisiopatologia , Epilepsia do Lobo Temporal/fisiopatologia , Hipocampo/patologia , Convulsões Febris/fisiopatologia , Sono/fisiologia , Adulto , Idoso , Anticonvulsivantes/uso terapêutico , Epilepsia Resistente a Medicamentos/diagnóstico por imagem , Epilepsia Resistente a Medicamentos/tratamento farmacológico , Eletroencefalografia , Epilepsia do Lobo Temporal/diagnóstico por imagem , Epilepsia do Lobo Temporal/tratamento farmacológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Esclerose , Adulto Jovem
12.
Nat Neurosci ; 22(10): 1598-1610, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31451802

RESUMO

Long-term memory formation is a major function of sleep. Based on evidence from neurophysiological and behavioral studies mainly in humans and rodents, we consider the formation of long-term memory during sleep as an active systems consolidation process that is embedded in a process of global synaptic downscaling. Repeated neuronal replay of representations originating from the hippocampus during slow-wave sleep leads to a gradual transformation and integration of representations in neocortical networks. We highlight three features of this process: (i) hippocampal replay that, by capturing episodic memory aspects, drives consolidation of both hippocampus-dependent and non-hippocampus-dependent memory; (ii) brain oscillations hallmarking slow-wave and rapid-eye movement sleep that provide mechanisms for regulating both information flow across distant brain networks and local synaptic plasticity; and (iii) qualitative transformations of memories during systems consolidation resulting in abstracted, gist-like representations.


Assuntos
Consolidação da Memória/fisiologia , Sono/fisiologia , Animais , Hipocampo/fisiologia , Humanos , Memória de Longo Prazo/fisiologia
13.
Orv Hetil ; 160(32): 1279-1283, 2019 Aug.
Artigo em Húngaro | MEDLINE | ID: mdl-31387375

RESUMO

Introduction: Short sleep duration and poor sleep quality may be associated with weight gain; this association has not yet been studied in Roma (Gipsy) population. Aim: Our aim was to study sleep patterns in two adult Roma subgroups (the wealthy Gabor and the poor Lovari Roma), compared to the majority of Hungarian population, in relation to obesity, knowing that Roma population has specific socio-cultural characteristics, with a rapidly changing lifestyle. Method: A population-based cross-sectional survey was conducted in a rural region in Transylvania, where the above groups are cohabiting. The groups were age- and gender-matched. Results: Sleep duration was 7.18 ± 1.6 hours in the Gabor Roma, 7.67 ± 1.5 hours in the Lovari Roma and 7.37 ± 1.5 hours in the non-Roma group. In average, 70% of them had enough sleep (≥7 hours). 38.6% of Gabor Roma, 27.1% of Lovari Roma and 23.5% of non-Roma had poor-quality sleep (p = 0.05). Gabor Roma had significantly higher body mass index (31.1 ± 4.6 versus 27.4 ± 5.2 and 28.66 ± 5.7 kg/m2, p = 0.004), and this correlated inversely with sleep duration (F = 14.85, p<0.000). Conclusion: Gabor Roma had significantly higher percentage of poor-quality sleep. Sleep duration and sleep quality were linked with obesity, mainly in the Roma population. Orv Hetil. 2019; 160(32): 1279-1283.


Assuntos
Obesidade/etiologia , Transtornos do Sono-Vigília/complicações , Sono/fisiologia , Adulto , Estudos Transversais , Humanos , Hungria/epidemiologia , Obesidade/epidemiologia , Obesidade/etnologia , Roma , População Rural
14.
Rev Assoc Med Bras (1992) ; 65(6): 845-850, 2019 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-31340315

RESUMO

OBJECTIVE: The purpose of this study was to investigate the prevalence of overweight and obesity and its association with sleep quality in university students from the Anhui province in China. METHODS: A cross-sectional study was conducted in China with 1328 participants. The prevalence of underweight and obesity in university students was estimated according to the reference working group on obesity in China. The sleep quality was evaluated using the standard PSQI (Pittsburgh Sleep Quality Index). RESULTS: This study included 470 male and 858 female students from a university in Anhui; 4.4% of the females and 17.7% of the males were overweight or obese. The prevalence of obesity in males was significantly higher than in females, and the prevalence of obesity in higher years was greater than in other years (p<0.05). In general, the mean score for sleep quality was 4.91±2.67; 36.5% of male and 39.1% of female students had poor sleep quality (PSQI score >5). Among the seven components of sleep quality, sleep duration and the use of sleep medication showed significant differences between male and female students and different years (p<0.05). An obvious correlation was found between sleep quality and body mass index (BMI)(p<0.000) in females who took hypnotic drugs. CONCLUSION: This study suggests that the sleep quality of females is probably associated with their BMI. College students are a special group of young adults whose cause of poor sleeping quality and BMI may be significant to study, so the health status of university students can be improved.


Assuntos
Índice de Massa Corporal , Obesidade/fisiopatologia , Transtornos do Sono-Vigília/fisiopatologia , Sono/fisiologia , Estudantes/estatística & dados numéricos , Magreza/fisiopatologia , China/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Obesidade/complicações , Obesidade/epidemiologia , Prevalência , Valores de Referência , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/etiologia , Inquéritos e Questionários , Magreza/complicações , Magreza/epidemiologia , Fatores de Tempo , Adulto Jovem
15.
J Nurs Adm ; 49(7-8): 350-353, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31335517

RESUMO

A quality improvement effort was designed to coordinate care in minimizing sleep interruptions to allow patients 6 or more hours of uninterrupted sleep. An interprofessional team developed a sleep protocol (HUSH) and coordinated care activities to reduce sleep interruptions on a 30-bed medical-surgical-telemetry unit. Changes in patient perceptions of noise and number of hours of restful sleep were compared before and after implementation. Results indicate a 9% improvement in quiet domain scores.


Assuntos
Unidades de Terapia Intensiva , Enfermagem Médico-Cirúrgica/organização & administração , Melhoria de Qualidade/organização & administração , Privação do Sono/prevenção & controle , Sono/fisiologia , Humanos , Ruído/prevenção & controle , Inquéritos e Questionários
16.
Health Qual Life Outcomes ; 17(1): 124, 2019 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-31311564

RESUMO

BACKGROUND: College life represents a key transitional period in the life of young adults that is marked by increased social engagement; living habits acquired during this period have implications on the future life of college students. Therefore, investigation of the determinants of health status of college students is a key imperative; however, there is limited evidence on the study of concomitant effects of physical activity (PA), sedentary time (ST), and sleep duration on the health-related quality of life (HRQOL) of college students. METHODS: This cross-sectional survey was conducted at a medical university in Shenyang in Northeast China in 2017. The study group comprised 926 undergraduate students. Data were collected by a self-administered questionnaire. PA, ST, sleep duration, and HRQOL were measured using the international physical activity questionnaire (IPAQ)-Long Form and the Chinese version of the 12-Item Short-Form Health Survey (SF-12). The association of PA, ST, and sleep duration with the HRQOL was examined using independent t-test, Pearson Chi-squared test, and multivariate linear regression analysis. RESULTS: After adjusting for potential confounding factors, students who reported high PA had significantly higher physical component summary (PCS) score in the total study population and among female students than those who reported low PA, whereas students who reported moderate PA had significantly higher PCS score only among female students (P < 0.05). In the total study population and among male students, students who slept for ≥9 h/day had significantly higher mental component summary (MCS) score than those who slept for 7-< 8 h/day, whereas among only male students, those who slept for 8-< 9 h/day had significantly higher MCS score (P < 0.05). The interaction term between ST and PA was not statistically significant. CONCLUSIONS: PA and sufficient sleep duration had a positive impact on the HRQOL of college students; however, ST was not associated with HRQOL and there was no interaction between the impact of ST and PA on the HRQOL of college students. Increasing PA and promoting adequate sleep duration are key health promotion strategies for college students.


Assuntos
Exercício , Qualidade de Vida , Comportamento Sedentário , Sono/fisiologia , Estudantes/estatística & dados numéricos , Adolescente , Adulto , China/epidemiologia , Estudos Transversais , Feminino , Nível de Saúde , Inquéritos Epidemiológicos , Humanos , Masculino , Análise Multivariada , Estudantes/psicologia , Adulto Jovem
17.
Medicine (Baltimore) ; 98(29): e16483, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31335712

RESUMO

RATIONALE: Electroencephalographic (EEG) changes are frequently observed not only by epileptic seizures but also by metabolic encephalopathies. The EEG changes during hypoglycemia are known as mixed frequency theta to delta activity with higher amplitude than the initial background rhythm. Although there are many reports about hypoglycemia induced EEG changes, few studies of hypoglycemic EEG patterns have been evaluated between arousal and sleep stage. PATIENT CONCERNS: A 45-year-old man who had been diagnosed as type 1 diabetes mellitus for 15 years admitted to the emergency room due to seizure attack. The EEG findings of the patient showed increased amplitude of theta slowing on both hemispheres. The abnormal EEG finding had recovered and the background frequency remarkably increased as the patient fell asleep, but reappeared when he woke up. DIAGNOSIS: The patient was diagnosed as hypoglycemia with altered mentality. INTERVENTIONS: Fifty percent dextrose fluid 50 mL was loaded and maintained with 10% dextrose water afterwards. OUTCOMES: The patient improved after medical treatment. LESSONS: The EEG presentation of hypoglycemia involves low frequency and increased amplitude of delta-theta activity. As the previous studies, we observed medium amplitude semi-rhythmic theta slowing EEG findings on both hemispheres during arousal, indicating hypoglycemia. However, it was stabilized during sleep as background frequency increased and medium amplitude of slowing disappeared. Although there are many reports about hypoglycemia induced EEG changes, few studies of hypoglycemic EEG patterns have been evaluated between arousal and sleep stage. We report a case of different EEG patterns between arousal and sleep stage during hypoglycemia.


Assuntos
Diabetes Mellitus Tipo 1/complicações , Eletroencefalografia , Hipoglicemia/etiologia , Hipoglicemia/fisiopatologia , Convulsões/etiologia , Convulsões/fisiopatologia , Nível de Alerta/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Sono/fisiologia
18.
Nature ; 571(7764): 198-204, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31292557

RESUMO

Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide activity recording coupled with assessment of eye movement, muscle dynamics and heart rate-that there are at least two major sleep signatures in zebrafish. These signatures, which we term slow bursting sleep and propagating wave sleep, share commonalities with those of slow-wave sleep and paradoxical or rapid eye movement sleep, respectively. Further, we find that melanin-concentrating hormone signalling (which is involved in mammalian sleep) also regulates propagating wave sleep signatures and the overall amount of sleep in zebrafish, probably via activation of ependymal cells. These observations suggest that common neural signatures of sleep may have emerged in the vertebrate brain over 450 million years ago.


Assuntos
Neurônios/fisiologia , Sono/fisiologia , Peixe-Zebra/fisiologia , Animais , Evolução Biológica , Encéfalo/citologia , Encéfalo/efeitos dos fármacos , Encéfalo/fisiologia , Encéfalo/fisiopatologia , Epêndima/citologia , Movimentos Oculares , Fluorescência , Frequência Cardíaca , Hipnóticos e Sedativos/farmacologia , Hormônios Hipotalâmicos/metabolismo , Melaninas/metabolismo , Neurônios/efeitos dos fármacos , Pigmentação/fisiologia , Hormônios Hipofisários/metabolismo , Polissonografia/métodos , Sono/efeitos dos fármacos , Privação do Sono/fisiopatologia , Sono REM/efeitos dos fármacos , Sono REM/fisiologia , Sono de Ondas Lentas/efeitos dos fármacos , Sono de Ondas Lentas/fisiologia
20.
NeuroRehabilitation ; 44(4): 511-521, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31256090

RESUMO

BACKGROUND: Many with a history of mild traumatic brain injury (TBI) experience sleep problems, which are also common symptoms of stress-related and mood disorders. OBJECTIVE: To determine if sleep problems contributed unique variance to post-concussive symptoms above and beyond symptoms of posttraumatic stress disorder/major depressive disorder (PTSD/MDD) after mild TBI. METHODS: 313 active duty service members with a history of mild TBI completed sleep, PTSD, and mood symptom questionnaires, which were used to determine contributions to the Neurobehavioral Symptom Inventory. RESULTS: 59% of the variance in post-concussive symptoms were due to PTSD symptom severity while depressive symptoms and sleep problems contributed an additional 1% each. This pattern differed between those with and without clinical diagnosis of PTSD/MDD. For those with PTSD/MDD, PTSD and depression symptoms but not sleep contributed to post-concussive symptoms. For those without PTSD/MDD, PTSD symptoms and sleep contributed specifically to somatosensory post-concussive symptoms. Daytime dysfunction and sleep disturbances were associated with post-concussive symptoms after PTSD and depression symptoms were controlled. CONCLUSIONS: PTSD symptom severity explained the most variance for post-concussive symptoms among service members with a history of mild TBI, while depression symptoms, daytime dysfunction, and sleep disturbances independently contributed small amounts of variance.


Assuntos
Concussão Encefálica/psicologia , Transtorno Depressivo Maior , Militares/psicologia , Síndrome Pós-Concussão/psicologia , Transtornos do Sono-Vigília/psicologia , Transtornos de Estresse Pós-Traumáticos , Adulto , Concussão Encefálica/diagnóstico , Concussão Encefálica/epidemiologia , Feminino , Humanos , Masculino , Síndrome Pós-Concussão/diagnóstico , Síndrome Pós-Concussão/epidemiologia , Autorrelato , Sono/fisiologia , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/epidemiologia , Inquéritos e Questionários
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