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1.
Quintessence Int ; 0(0): 0, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33491394

RESUMO

Objective: This study analyzed two xenogenous biomaterials based on deproteinized bovine bone mineral applied for maxillary sinus elevation. Method and materials: Fourteen patients were submitted to maxillary sinus augmentation with one of the following biomaterials: Criteria Lumina Bone Porous (test group) or Geistlich Bio-Oss (control group), both of large granules (1 to 2 mm). After 6 months, trephine biopsies were collected at the time of implant placement: 27 samples (11 patients) in the test group; 7 samples (3 patients) in the control group. Biopsies were analyzed by descriptive histology and histomorphometry, in which the percentages of newly formed bone, residual biomaterial particles, and connective tissue were evaluated. Results: Histomorphometry showed means for test and control groups, respectively, of 32.41% ± 9.42% and 26.59% ± 4.88% for newly formed bone, 22.89% ± 4.58% and 25.00% ± 4.81% for residual biomaterial, and 44.70% ± 9.54% and 48.41% ± 3.36% for connective tissue. There were no differences between groups (P > .05). Conclusion: This study concluded that Criteria Lumina Bone Porous presented similar histologic and histomorphometric characteristics to Geistlich Bio-Oss 6 months after sinus elevation surgery, identifying the tested biomaterial as an interesting alternative for bone augmentation in the maxillary sinus.


Assuntos
Substitutos Ósseos , Levantamento do Assoalho do Seio Maxilar , Animais , Materiais Biocompatíveis , Transplante Ósseo , Bovinos , Implantação Dentária Endo-Óssea , Humanos , Maxila , Seio Maxilar/cirurgia , Minerais
2.
J Appl Oral Sci ; 29: e20200568, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33331393

RESUMO

OBJECTIVE: The aim of this study is to evaluate the new bone and connective tissue formation and the biomaterial remaining after maxillary sinus bone augmentation using 5 different bone substitutes. The osteocalcin immunolabeling was performed to demonstrate their calcification and the possibility of receiving dental implants. METHODOLOGY: 40 patients underwent maxillary sinus bone augmentation and were divided in 5 groups: Group 1 with 8 maxillary sinuses were grafted with autogenous bone graft (AB); Group 2 with 8 maxillary sinuses grafted with bioactive glass (BG); Group 3 with 8 maxillary sinuses grafted with bioactive glass added to autogenous bone graft (BG + AB) 1:1; Group 4 with 8 maxillary sinuses grafted with Bio-Oss (BO) and Group 5 with 8 maxillary sinuses grafted with Bio-Oss added to autogenous bone graft (BO + AB) 1:1. RESULTS: In group AB, 37.8% of bone was formed in the pristine bone region, 38.1% in the intermediate and 44.5% in the apical region. In group BG, 43.6% was formed in the pristine bone, 37% in the intermediate and 49.3% in the apical region. In group BG + AB 1:1, 39.0% was formed in the pristine bone region, 34.8% in the intermediate and 36.8% in apical region. In group BO, 33.4% was formed in the pristine bone, 32.5% in the intermediate and 34.3% in the apical region. In group BO + AB 1:1, 32.8% was formed in the pristine bone, 36.1% in intermediate and 27.8% in the apical regions. The immunolabeling for osteocalcin showed an intensive staining for all groups, which could demonstrate the calcification of the bone formed. CONCLUSION: This study showed that the groups evaluated formed a suitable lamellar bone in the maxillary sinus reconstruction after six months of bone healing, thus being indicated to receive dental implants.


Assuntos
Substitutos Ósseos , Transplante Ósseo , Implantes Dentários , Osteogênese , Levantamento do Assoalho do Seio Maxilar , Implantação Dentária Endo-Óssea , Humanos , Seio Maxilar/diagnóstico por imagem , Seio Maxilar/cirurgia
3.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 55(11): 908-914, 2020 Nov 09.
Artigo em Chinês | MEDLINE | ID: mdl-33171567

RESUMO

Objective: To evaluate the effects of fluorinated porcine hydroxyapatite (FPHA) on guided bone regeneration of peri-implant buccal bone defects in canine mandible. Methods: Six male beagle dogs were randomly divided into two groups with different time points (4 weeks and 12 weeks after implants placement), with 3 dogs in each group. Bilateral mandibular second premolars, first molars, and second molars in each dog were extracted. The wounds were allowed to heal for 12 weeks. For each dog, four implant beds were prepared in each side and standardized peri-implant buccal bone defect was created at each implant site. After implants placement, the defect sites were randomly allocated in a split-mouth design to blank control group, deproteinized bovine bone mineral (DBBM), the porcine hydroxyapatite (PHA), FPHA and covered with collagen membranes. The animals were sacrificed 4 or 12 weeks after the surgery. Biopsies of the implant sites were obtained for micro-CT evaluation [bone volume fraction (BV/TV) and bone trabecular separation degree (Tb.Sp)] and histological analysis. Results: Micro-CT results showed that 4 weeks after implants placement, PHA, FPHA and DBBM successfully maintained the contour of alveolar ridge at the buccal aspect of the implants, while the contour of alveolar ridge collapsed in the blank control group. BV/TV in the FPHA group [(24.77±2.20) %] was significantly higher than that in the PHA group [(16.89±1.70)%] and DBBM group [(15.68±3.15)%] (P<0.05). Tb.Sp in the FPHA group (0.70±0.07) was significantly lower than that in the DBBM group (1.03±0.19) (P<0.05). Twelve weeks after implants placement, the alveolar ridge contour of the grafted sites in PHA, FPHA and DBBM group remained stable. The alveolar ridge of the blank control group was still collapsed. There was no significant difference in BV/TV and Tb.Sp between PHA group, FPHA group and DBBM group. The histomorphological analysis showed that 4 weeks after implants placement, in the central area of the defect, the amount and maturity of new bone (NB) around the material particles in FPHA group was higher than that in PHA group and DBBM group. Osseointegration could be observed between the NB and implant surface in all the four groups. Twelve weeks after implants placement, the material particles were surrounded by a large number of mature NB in PHA, FPHA and DBBM group. Conclusions: The incorporation of fluoride ion into PHA could effectively promote the repair of peri-implant bone defects in the early stage of guided bone regeneration.


Assuntos
Substitutos Ósseos , Implantes Dentários , Animais , Regeneração Óssea , Bovinos , Implantação Dentária Endo-Óssea , Cães , Durapatita , Masculino , Mandíbula/cirurgia , Membranas Artificiais , Osseointegração , Suínos
4.
Artigo em Inglês | MEDLINE | ID: mdl-33151186

RESUMO

This study presents the histomorphometric results of the Wafer Technique, which is based on guided bone regeneration and onlay grafts for 3D bone augmentation. This two-stage technique utilizes autogenous cortical bone plates and collagen membranes, forming a barrier containing a mixture of deproteinized bovine bone matrix, autologous blood, and bone grafted from intraoral sites. Twelve patients were treated. At 6 months postsurgery, histologic analysis of the regenerated areas revealed the presence of compact newly formed bone with no sign of inflammation. The percentages of new bone and native bone (mineralized tissue) were 16.4% (95% CI: 9.5% to 23.2%) and 42.6% (95% CI: 28.2% to 57.0%), respectively. Twenty-five implants were placed. The procedure has been proven to be safe and reliable, and only one transient complication was observed.


Assuntos
Aumento do Rebordo Alveolar , Substitutos Ósseos , Implantes Dentários , Animais , Regeneração Óssea , Transplante Ósseo , Bovinos , Implantação Dentária Endo-Óssea , Regeneração Tecidual Guiada Periodontal , Humanos , Membranas Artificiais
5.
Shanghai Kou Qiang Yi Xue ; 29(4): 427-430, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-33089296

RESUMO

PURPOSE: To investigate the effect of Bio-Oss bone powder combined with platelet-rich fibrin on bone mass after implantation-guided bone regeneration in alveolar bone defects. METHODS: One hundred and six patients with single anterior tooth loss and labial alveolar bone defect were selected for implant implantation and guided bone regeneration at the same time. Patients in the experimental group (n=53) were treated with Bio-Oss bone powder combined with platelet-rich fibrin and biofilm to guide bone regeneration, while patients in the control group(n=53) were treated with Bio-Oss bone powder combined with biofilm to guide bone regeneration. The success rate of implantation, complication rate, the thickness of labial bone wall and the regeneration of bone defect were observed. Statistical analysis was performed on the data using SPSS 25.0 software package. RESULTS: There was no significant difference in the success rate of implants between the two groups(96.23% vs 88.68%, P>0.05). The thickness of the labial bone wall of the experimental group 12 months after implantation was significantly higher than that of the control group[(2.72±0.43) mm vs(2.51±0.36) mm], and the thickness of the labial wall of the implant at different sites was significantly greater than that of the control group(P<0.05). Bleeding index [(0.32±0.02) vs (0.42±0.03)], depth of probing [(3.31±0.69) mm vs (4.32±0.95) mm], loss of attachment [(3.06±0.52) mm vs (5.24±1.35) mm] was significantly smaller in the experimental group than in the control group (P<0.05); bone graft height [(2.61±0.52) mm vs (2.31±0.35) mm], osteogenesis height [(2.59±0.32) mm vs (2.01±0.16) mm] was significantly greater in the experimental group than in the control group(P<0.05). There was no significant difference in the incidence of complications between the two groups(1.89% vs 5.66%, P>0.05). CONCLUSIONS: Bio-Oss bone powder combined with platelet-rich fibrin can reduce bone loss and promote bone defect regeneration after guided bone regeneration.


Assuntos
Substitutos Ósseos , Fibrina Rica em Plaquetas , Regeneração Óssea , Humanos , Minerais
6.
Shanghai Kou Qiang Yi Xue ; 29(3): 316-320, 2020 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-33043352

RESUMO

PURPOSE: To investigate the effect of autologous concentrated growth factor fibrin solution combined with Bio-Oss bone powder on mucosal healing and bone regeneration after oral implanted guided bone regeneration. METHODS: From October 2016 to December 2018, 83 patients with maxillary single anterior tooth loss and labial bone defect were treated, they were divided into two groups. Patients in the experimental group (42 cases) received autologous concentrated growth factor fibrin solution + Bio-Oss bone powder, while patients in the control group (41 cases) received Bio-Oss bone powder alone. The degree of mucosal healing, implant success, bone defect regeneration, pain and other complications were followed up 7 days, 6 weeks and 1 year after operation. The success rate and complications of the two groups were observed, as well as the differences of mucosal color, swelling degree, bleeding index, depth of probing, attachment loss, height of bone graft and thickness of bone formation were measured and recorded. Statistical analysis was performed using SPSS 25.0 software package. RESULTS: There was no significant difference in the success rate of implants between the two groups (95.24% vs 97.56%, P>0.05). The complication rate of the experimental group was significantly lower than that of the control group (2.38% vs 14.63%, P<0.05). The mucosal color and swelling degree scores of the experimental group were significantly lower than those of the control group [(0.65±0.03) points vs (2.01±0.15) points, (1.10±0.37) points vs (2.69±0.54) points, P<0.05], and the bleeding index, probing depth, and attachment loss were significantly lower than the control group [(0.35±0.05) vs (0.49±0.09), (3.39±0.62) mm vs (4.41±0.95) mm, (3.02±0.66) mm vs (5.31±0.91) mm, P<0.05], bone graft height and osteogenesis height were significantly higher than the control group [(2.61±0.50) mm vs (2.20±0.31) mm, (2.53±0.34) mm vs (2.02±0.27) mm, P<0.05]. The degree of postoperative pain in the experimental group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Rich self-concentrating growth factor fibrin solution combined with Bio-Oss bone powder can effectively promote mucosal healing and bone regeneration after oral implant-guided bone regeneration, and reduce postoperative pain and complications.


Assuntos
Substitutos Ósseos , Implantes Dentários , Regeneração Óssea , Fibrina , Humanos , Minerais
7.
PLoS One ; 15(9): e0238471, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32870933

RESUMO

Bone scaffolds are widely used as one of the main bone substitute materials. However, many bone scaffold microstructure topologies exist and it is still unclear which topology to use when designing scaffold for a specific application. The aim of the present study was to reveal the mechanism of the microstructure-driven performance of bone scaffold and thus to provide guideline on scaffold design. Finite element (FE) models of five TPMS (Diamond, Gyroid, Schwarz P, Fischer-Koch S and F-RD) and three traditional (Cube, FD-Cube and Octa) scaffolds were generated. The effective compressive and shear moduli of scaffolds were calculated from the mechanical analysis using the FE unit cell models with the periodic boundary condition. The scaffold permeability was calculated from the computational fluid dynamics (CFD) analysis using the 4×4×4 FE models. It is revealed that the surface-to-volume ratio of the Fischer-Koch S-based scaffold is the highest among the scaffolds investigated. The mechanical analysis revealed that the bending deformation dominated structures (e.g., the Diamond, the Gyroid, the Schwarz P) have higher effective shear moduli. The stretching deformation dominated structures (e.g., the Schwarz P, the Cube) have higher effective compressive moduli. For all the scaffolds, when the same amount of change in scaffold porosity is made, the corresponding change in the scaffold relative shear modulus is larger than that in the relative compressive modulus. The CFD analysis revealed that the structures with the simple and straight pores (e.g., Cube) have higher permeability than the structures with the complex pores (e.g., Fischer-Koch S). The main contribution of the present study is that the relationship between scaffold properties and the underlying microstructure is systematically investigated and thus some guidelines on the design of bone scaffolds are provided, for example, in the scenario where a high surface-to-volume ratio is required, it is suggested to use the Fischer-Koch S based scaffold.


Assuntos
Transplante Ósseo/métodos , Osso e Ossos/patologia , Tecidos Suporte/química , Substitutos Ósseos/farmacologia , Força Compressiva , Análise de Elementos Finitos , Hidrodinâmica , Teste de Materiais , Permeabilidade , Porosidade , Pressão , Estresse Mecânico , Engenharia Tecidual/métodos
8.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(6): 684-692, 2020 Jun 28.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-32879126

RESUMO

OBJECTIVES: To evaluate the repairing ability of nano-pearl powder bone substitute in rabbit with defect of distal femur bone. METHODS: Thirty-two New Zealand rabbits were randomly divided into four groups: a nano-pearl powder/recombinant human bone morphogenetic protein 2 (rhBMP-2)/hyaluronic acid group, a nano-pearl powder/hyaluronic acid group, a nano-pearl powder group and a blank control group (n=8 in each group). A defect with the diameter of 7 mm and height of 10 mm was prepared at the distal femoral metaphysis line of the rabbit.Different bone substitutes were planted, and the effect of repair was evaluated by macroscopic observation, imaging examination, and histopathological examination. RESULTS: The results of imageology showed that: the bone repairing effect in the nano-pearl powder/rhBMP-2/hyaluronic acid group was better than that in the pure pearl powder group and the nano-pearl powder/hyaluronic acid group, and which in the 3 experimental groups was better than that in the blank control group; The results of histology showed that: at the 4th, 8th and 12th weeks after the modeling operation, the speed of bone repair in the nano-pearl powder/rhBMP-2/hyaluronic acid group was faster than that in the pure pearl powder group and the nano-pearl powder/hyaluronic acid group, and which in the blank control group was far slower than that in the 3 experimental groups. The results of immunohistochemistry staining for osteocalcin antibody showed that: the osteogenic effect in the nano-pearl powder/rhBMP-2/hyaluronic acid group was better than that in the pure pearl powder group and the nano-pearl powder/hyaluronic acid group (both P<0.05); there was no significant difference between the nano-pearl powder/hyaluronic acid group and the pure pearl powder group (P>0.05); however, there was significant difference between the pure pearl powder group and the blank control group (P<0.05). According to the staining results of Type I collagen antibody, there was no significant difference in the osteogenic effect between the nano-pearl powder/rhBMP-2/hyaluronic acid group and the nano-pearl powder/hyaluronic acid group (P>0.05), but the osteogenic effect in the nano-pearl powder/hyaluronic acid group was better than that in the pure pearl powder group and the blank control group (both P<0.05). CONCLUSIONS: Nano-pearl powder and its bone substitute can promote the repair of bone defect, and the nano-pearl powder which contains rhBMP-2 has better osteogenic and repairing effect on defect.


Assuntos
Substitutos Ósseos , Animais , Proteína Morfogenética Óssea 2 , Colágeno , Fêmur , Humanos , Osteogênese , Pós , Coelhos , Proteínas Recombinantes , Fator de Crescimento Transformador beta
9.
Med. oral patol. oral cir. bucal (Internet) ; 25(5): e565-e575, sept. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-196511

RESUMO

BACKGROUND: Many studies have addressed socket preservation, though fewer publications considering buccal wall loss can be found, since the literature typically considers sockets with four walls. A systematic review was made on the influence of type II buccal bone defects, according to Elian's Classification, in socket grafting materials upon volumetric changes in width and height. MATERIAL AND METHODS: An electronic and manual literature search was conducted in accordance to PRISMA statement. The search strategy was restricted to randomized controlled trials (RCTs) and controlled clinical trials (CCTs) describing post-extraction sockets with loss of buccal wall in which alveolar ridge preservation (ARP) was carried out in the test group and spontaneous healing of the socket (SH) was considered in the control group. RESULTS: The search strategy yielded 7 studies. The meta-analysis showed an additional bone loss of 2.37 mm in width (p > 0.001) and of 1.10 mm in height (p > 0.001) in the absence of ARP. The reconstruction of the vestibular wall was not evaluated in any study. The results also showed moderate to great heterogeneity among the included studies in terms of the changes in width and height. CONCLUSIONS: Despite the heterogeneity of the included studies, the results indicate a benefit of ARP versus SH. Further studies are needed to determine the volumetric changes that occur when performing ARP in the presence of a buccal bone wall defect


No disponible


Assuntos
Humanos , Processo Alveolar/cirurgia , Extração Dentária/métodos , Boca/cirurgia , Alvéolo Dental/cirurgia , Ensaios Clínicos como Assunto , Substitutos Ósseos/uso terapêutico , Preservação Biológica
10.
Int J Nanomedicine ; 15: 5027-5042, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32764934

RESUMO

Background: Bactericidal capacity, durable inhibition of biofilm formation, and a three-dimensional (3D) porous structure are the emphases of infected bone defect (IBD) treatment via local scaffold implantation strategy. Purpose: In this study, silver nanoparticle (AgNP)-loaded nano-hydroxyapatite (nHA)@ reduced graphene oxide (RGO) 3D scaffolds (AHRG scaffolds) were designed to alleviate bone infection, inhibit biofilm formation, and promote bone repair through the synergistic effects of AgNPs, RGO, and nHA. Materials and Methods: AHRGs were prepared using a one-step preparation method, to create a 3D porous scaffold to facilitate a uniform distribution of AgNPs and nHA. Methicillin-resistant Staphylococcus aureus (MRSA) was used as a model-resistant bacterium, and the effects of different silver loadings on the antimicrobial activity and cytocompatibility of materials were evaluated. Finally, a rabbit IBD model was used to evaluate the therapeutic effect of the AHRG scaffold in vivo. Results: The results showed successful synthesis of the AHRG scaffold. The ideal 3D porous structure was verified using scanning electron microscopy and transmission electron microscopy, and X-ray photoelectron spectroscopy and selected area electron diffraction measurements revealed uniform distributions of AgNP and nHA. In vitro antibacterial and cytocompatibility indicated that the 4% AHRG scaffolds possessed the most favorable balance of bactericidal properties and cytocompatibility. In vivo evaluation of the IBD model showed promising treatment efficacy of AHRG scaffolds. Conclusion: The as-fabricated AHRG scaffolds effectively eliminated infection and inhibited biofilm formation. IBD repair was facilitated by the bactericidal properties and 3D porous structure of the AHRG scaffold, suggesting its potential in the treatment of IBDs.


Assuntos
Antibacterianos/farmacologia , Doenças Ósseas Infecciosas/terapia , Grafite/química , Nanopartículas Metálicas/química , Engenharia Tecidual/métodos , Tecidos Suporte/química , Animais , Antibacterianos/química , Biofilmes/efeitos dos fármacos , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos , Osso e Ossos/efeitos dos fármacos , Modelos Animais de Doenças , Durapatita/química , Feminino , Masculino , Teste de Materiais , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Porosidade , Coelhos , Ratos , Prata/química , Prata/farmacologia , Infecções Estafilocócicas/terapia
11.
Clin Oral Implants Res ; 31(10): 1025-1036, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32790921

RESUMO

OBJECTIVE: To test the hypotheses of no differences in (I) percentage of bone (POB), non-mineralized tissue (NMT), and deproteinized bovine bone mineral (DBBM), and (II) ingrowth of mineralized bone after lateral guided bone regeneration (GBR) augmentation of the mandible with different ratios of DBBM and particulate autogenous bone (PAB) at different time points. MATERIAL AND METHODS: Twenty-four minipigs were randomly allocated into three groups. Lateral augmentation in 96 sites (4 in each animal) was performed unilaterally with a standardized quantity of grafting material in each animal with different ratios of DBBM and PAB (50:50, 75:25, 100:0) and autogenous bone block in combination with DBBM and covered with a collagen membrane. The percentage of different tissues in the graft and ingrowth of mineralized bone was assessed by histomorphometrical and histological analyses after 10, 20, and 30 weeks, respectively. RESULTS: The POB was 54% (50:50), 50% (75:25), and 48% (100:0) after 10 weeks, 60% (50:50), 61% (75:25), and 60% (100:0) after 20 weeks, and 63% (50:50), 62% (75:25), and 62% (100:0) after 30 weeks. There was no significant difference between the groups at any time points. There was a significant increase in POB and a significant decrease in NMT for 75:25 and 100:0 from 10 to 30 weeks. All ratios demonstrated a non-complete ingrowth of mineralized bone into the graft after 10 weeks and complete mineralization after 30 weeks. CONCLUSION: Within the limitations of the present study, it seems like addition of autogenous bone to DBBM for LRA did not affect the bone formation nor graft incorporation after 10-30 weeks of healing. However, a prolonged healing time seems to result in an increased POB for all ratios.


Assuntos
Aumento do Rebordo Alveolar , Substitutos Ósseos/farmacologia , Animais , Regeneração Óssea , Transplante Ósseo , Bovinos , Mandíbula/cirurgia , Minerais , Suínos , Porco Miniatura
12.
Clin Oral Implants Res ; 31(10): 959-967, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32716570

RESUMO

OBJECTIVES: To evaluate graft remodelling according to the distance from the native bone in maxillary sinuses grafted with anorganic bovine bone (ABB). MATERIAL AND METHODS: Bilateral sinus grafting was performed in twenty patients with residual bone height <5 mm before implant placement. After 8 months, biopsy samples were harvested, and histomorphometric analysis was performed to examine bone formation according to the distance (in mm) from the native bone (sinus floor). In the grafted area, the percentages of new bone (NB), residual graft material (rABB), and soft tissue (ST) were evaluated. RESULTS: A total of 103 biopsy samples were evaluated, and the percentages of NB, rABB, and ST were 31.62 ± 9.85%, 18.94 ± 7.88%, and 49.41 ± 9.52%, respectively, in the 1st mm; 27.15 ± 9.83%, 23.33 ± 9.45%, and 49.53 ± 11.73%, respectively, in the 2nd mm; 23.61 ± 13.02%, 21.35 ± 11.08%, and 55.03 ± 16.14%, respectively, in the 3rd mm; and 21.67 ± 12.29%, 19.67 ± 10.28%, and 58.66 ± 12.46%, respectively, in the 4th mm. The 1st millimetre of the grafted area (closer to the native bone) presented a larger amount of NB than the other portions of the grafted areas and a smaller amount of rABB than the 2nd mm of the grafted area (p < .05). The amount of ST was larger in the 3rd and 4th mm of the grafted area than in the first 2 millimetres (p < .05). CONCLUSION: The distance from the native bone influences bone formation following maxillary sinus augmentation.


Assuntos
Substitutos Ósseos , Levantamento do Assoalho do Seio Maxilar , Animais , Transplante Ósseo , Bovinos , Humanos , Maxila/diagnóstico por imagem , Maxila/cirurgia , Seio Maxilar/diagnóstico por imagem , Seio Maxilar/cirurgia , Osteogênese
13.
Int J Oral Maxillofac Implants ; 35(4): 731-738, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32724924

RESUMO

PURPOSE: To evaluate the influence of bioactivation with argon plasma of a xenograft used as graft material for sinus floor augmentation. MATERIALS AND METHODS: Sinus floor elevation was performed in 20 rabbits using a deproteinized bovine bone mineral as graft material. The xenograft used in the test sites was bioactivated with argon plasma (plasma group), while that used in the control sites was left untreated (control group). Collagen membranes were used to cover the antrostomy. The rabbits were euthanized after 2 and 10 weeks, in groups of 10 each. A histomorphometric analysis was performed in various regions of the elevated space. RESULTS: After 2 weeks of healing, a similar pattern of healing was observed in both groups. New bone fractions were 5.2% ± 2.9% in the plasma group and 5.0% ± 3.5% in the control group (P = .795). In this period, higher amounts of new bone were found in the region close to the sinus bone walls. After 10 weeks of healing, the amounts of new bone within the elevated space increased to 23.5% ± 7.0% and 21.3% ± 7.3% (P = .176) in the plasma and control groups, respectively. The only statistically significant difference was found in the central region, with 20.4% ± 9.7% in the plasma group and 13.2% ± 10.5% in the control group (P = .037). CONCLUSION: The bioactivation of a xenograft using argon plasma improved bone formation within an augmented sinus, especially in the central regions, far from osteogenic sources.


Assuntos
Substitutos Ósseos , Gases em Plasma , Levantamento do Assoalho do Seio Maxilar , Animais , Argônio , Matriz Óssea , Transplante Ósseo , Bovinos , Seio Maxilar , Minerais , Coelhos
14.
Int J Oral Maxillofac Implants ; 35(4): 739-748, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32724925

RESUMO

PURPOSE: To compare the osseointegration at the portion of the implant within the elevated space after sinus elevation using different sizes of xenograft. MATERIALS AND METHODS: Eighteen New Zealand rabbits were selected, antrostomies were prepared bilaterally through the nasal dorsum, and the sinus mucosa was elevated. Deproteinized bovine bone mineral with granules of either 1 to 2 mm (large sites) or 0.250 to 1.0 mm (small sites) were randomly used to fill the elevated space of the two sinuses. Subsequently, mini-implants were placed through the antrostomy, one in each sinus. The animals were euthanized 2, 4, and 8 weeks after surgery, six animals for each group. Microcomputed tomography (micro-CT) and histologic analyses were performed. RESULTS: In the elevated space, at the histologic analysis after 2 weeks of healing, new bone formed on the implant surface was found in fractions of 18.8% ± 6.8% and 15.8% ± 9.6% in the large and small sites, respectively (P = .249). After 4 weeks, the respective fractions of new bone were 20.3% ± 3.5% and 23.3% ± 5.6% (P = .249). After 8 weeks, the proportions reached 33.9% ± 9.5% and 28.5% ± 10.3% (P = .173), respectively. At the micro-CT analysis, bone-to-implant contact percentage (BIC%) was 21.0% ± 2.3% and 21.2% ± 2.4% in the large and small sites, respectively (P = 1.000). The respective proportions of BIC% at the large and small sites were 20.5% ± 3.3% and 23.4% ± 5.4% after 4 weeks (P = .463), and 23.0% ± 2.7% and 25.8% ± 4.1% after 8 weeks (P = .249). CONCLUSION: The use of xenograft granules of different dimensions resulted in similar amounts of bone-to-implant contact at implants placed simultaneously with sinus floor augmentation.


Assuntos
Substitutos Ósseos , Implantes Dentários , Levantamento do Assoalho do Seio Maxilar , Animais , Transplante Ósseo , Implantação Dentária Endo-Óssea , Xenoenxertos , Seio Maxilar/cirurgia , Osseointegração , Coelhos , Microtomografia por Raio-X
15.
Vasc Endovascular Surg ; 54(8): 734-740, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32729383

RESUMO

BACKGROUND: Arteriovenous malformations (AVMs) are rare, congenital vascular anomalies. Intraosseous AVMS most frequently arise in the head and neck, with only a small fraction occurring in the extremities. Herein, we report the findings of a combined soft tissue and intraosseous AVM involving the lower extremity of a 13-year-old child. This case highlights the necessity of an interdisciplinary approach for the effective treatment and management of these rare vascular anomalies. CASE DESCRIPTION: A 13-year-old female presented with a 4-year history of intermittent pain and swelling over her right lateral malleolus. The patient was evaluated with radiologic imaging revealing an AVM involving the right distal leg, ankle, and hindfoot with intraosseous involvement of the distal tibia and talus. She was then referred to Vascular and Plastic Surgery and an angiogram was performed demonstrating shunting from the anterior tibial, peroneal, and posterior tibial arteries to the AVM. Venous drainage was to the anterior tibial and greater saphenous veins. Three embolizations were performed over the course of 6 months. Following the third embolization, the patient was taken to the operating room where Plastic and Orthopedic Surgery performed total resection of the nidus and involved bone which was then grafted with injectable synthetic bone graft. RESULTS: Successful resection of the nidus was achieved, and the patient had an uncomplicated recovery. Within 6 months postoperatively, the patient demonstrated full range of lower extremity motion and was able to participate in age appropriate gross motor activities. Radiologic evaluation 7 months postoperatively showed no evidence of nidus recurrence. CONCLUSION: Intraosseous involvement of AVMS is rare and presents a therapeutic challenge due to its invasive potential and high incidence of recurrence. Wide local excision with bone grafting and interdisciplinary management are paramount for complete resection.


Assuntos
Malformações Arteriovenosas/diagnóstico por imagem , Malformações Arteriovenosas/terapia , Substitutos Ósseos/uso terapêutico , Embolização Terapêutica , Osteotomia , Tálus/irrigação sanguínea , Tíbia/irrigação sanguínea , Adolescente , Malformações Arteriovenosas/fisiopatologia , Feminino , Humanos , Resultado do Tratamento
16.
Artigo em Inglês | MEDLINE | ID: mdl-32650587

RESUMO

PURPOSE: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of ß-Ca3(PO4)2 to α-Ca3(PO4)2. This analysis explored, in an innovative way, inferences and correlations between volumetric microstructure, mechanical properties, sintering temperature, and time at peak temperature in order to find the best sintering conditions for biphasic calcium phosphate composites grafted in severe alveolar bone defects. METHODS: Sintered biphasic calcium phosphates (30%-hydroxyapatite/70%-tricalcium phosphate) were tested by microCT imaging for the 3D morphometric analysis, by compressive loading to find their mechanical parameters, and by X-ray diffraction to quantify the phases via Rietveld refinement for different sintering temperatures and times at the peak temperature. Data were analysed in terms of statistical inference using Pearson's correlation coefficients. RESULTS: All the studied scaffolds closely mimicked the alveolar organization of the jawbone, independently on the sintering temperatures and times; however, mechanical testing revealed that the group with peak temperature, which lasted for 2 hours at 1250 °C, showed the highest strength both at the ultimate point and at fracture point. CONCLUSION: The good mechanical performances of the group with peak temperature, which lasted for 2 hours at 1250 °C, is most likely due to the absence of the α-Ca3(PO4)2 phase, as revealed by X-ray diffraction. However, we detected its presence after sintering at the same peak temperature for longer times, showing the time-dependence, combined with the temperature-dependence, of the ß-Ca3(PO4)2 to α-Ca3(PO4)2 transition.


Assuntos
Substitutos Ósseos , Hidroxiapatitas , Materiais Biocompatíveis , Durapatita , Difração de Raios X
17.
Adv Exp Med Biol ; 1250: 177-188, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32601945

RESUMO

Biphasic calcium phosphate bioceramics consist of an intimate mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (ß-TCP) in varying ratios. Due to their biocompatibility, osteoconductivity, and safety in in vitro, in vivo, and clinical models, they have become promising bone substitute biomaterials and are recommended for use as alternatives for or as additives in bone tissue regeneration in various orthopedic and dental applications. Many studies have demonstrated the potential uses of BCP bioceramics as scaffolds for tissue engineering. Here, we highlight the recent advances in the uses of BCP bioceramics and functionalized BCPs for bone tissue regeneration.


Assuntos
Regeneração Óssea , Substitutos Ósseos , Hidroxiapatitas , Substitutos Ósseos/química , Substitutos Ósseos/normas , Humanos
18.
J Am Acad Orthop Surg ; 28(20): e888-e899, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-32701688

RESUMO

Bone marrow edema (BME) is a descriptive term used to describe high-signal intensity changes detected on magnetic resonance fluid-sensitive sequences that could be attributed to a number of underlying pathologies. Regardless of the cause, physiologic remodeling of the subchondral bone can be limited because of ongoing joint forces, increased focalization of stress, and reduced healing capacity of the subchondral bone. BME is a known prognostic factor associated with pain, dysfunction, and progressive cartilage damage. This review summarizes the current known causes of BMEs, theories related to histopathological changes, and current treatment options including novel biologic surgical options.


Assuntos
Doenças da Medula Óssea/etiologia , Doenças da Medula Óssea/terapia , Fosfatos de Cálcio/economia , Edema/etiologia , Edema/terapia , Adulto , Doenças da Medula Óssea/diagnóstico por imagem , Doenças da Medula Óssea/patologia , Substitutos Ósseos/administração & dosagem , Fosfatos de Cálcio/administração & dosagem , Cartilagem Articular/patologia , Tratamento Conservador , Imagem de Difusão por Ressonância Magnética , Edema/diagnóstico por imagem , Edema/patologia , Feminino , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Procedimentos Ortopédicos , Dor/etiologia , Prognóstico
19.
Med. oral patol. oral cir. bucal (Internet) ; 25(4): e474-e480, jul. 2020. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-196499

RESUMO

BACKGROUND: The aim of this study was to assess one-year implant survival after lateral window sinus augmentation using PRGF combined with various bone grafting materials. MATERIAL AND METHODS: This was a retrospective chart review and radiographic analysis of patients that had under-gone lateral window sinus augmentation with PRGF and had dental implants placed at least 6 months post augmentation. All implants included were followed up for at least one year after placement. Demographic, sinus and implant related characteristics (residual ridge height, sinus membrane perforation, type of graft material, implant length and width and ISQ at placement) were analyzed. RESULTS: A total of 31 patients with 39 sinus augmentations and 48 implants were included. The mean follow up was 22.8 ± 9.9 months. Implant survival was 95.8%, with 2 implants overall failing. Among all the variables assessed, the only one found to be associated with an increased risk for implant failure was the use of xenograft as bone grafting material in the sinus. CONCLUSIONS: Within the limitations of this study, dental implants placed in maxillary sinuses grafted with PRGF in combination with bone grafting materials, exhibit high implant survival rates after at least one year follow up


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Levantamento do Assoalho do Seio Maxilar/métodos , Plasma Rico em Plaquetas , Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico , Implantação Dentária Endo-Óssea/métodos , Estudos Retrospectivos , Substitutos Ósseos/uso terapêutico , Resultado do Tratamento , Fatores de Tempo , Fatores de Risco , Tomografia Computadorizada de Feixe Cônico
20.
Med. oral patol. oral cir. bucal (Internet) ; 25(4): e532-e540, jul. 2020. ilus, graf, tab
Artigo em Inglês | IBECS | ID: ibc-196507

RESUMO

BACKGROUND: The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (Beta-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. MATERIAL AND METHODS: CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (Beta-TCP-Fn, Beta-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). RESULTS: 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the Beta-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the Beta-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056). CONCLUSIONS: Both Beta-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with Beta-TCP-Fn are significantly better in short healing time when comparing with controls but not for Beta-TCP used alone in rats calvarial CSDs


No disponible


Assuntos
Animais , Masculino , Ratos , Regeneração Tecidual Guiada/métodos , Regeneração Óssea/efeitos dos fármacos , Fosfatos de Cálcio/farmacologia , Fibronectinas/farmacologia , Substitutos Ósseos/farmacologia , Ratos Sprague-Dawley , Resultado do Tratamento , Fatores de Tempo , Crânio/cirurgia , Valores de Referência , Reprodutibilidade dos Testes
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