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1.
Zhongguo Zhong Yao Za Zhi ; 46(18): 4730-4735, 2021 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-34581082

RESUMO

The present study aimed to explore the mechanism of the sweating of Dipsacus asper on content changes of triterpene sa-ponins by detecting the total triterpene saponins and the index component asperosaponin Ⅵ in the crude and sweated D. asper, and analyzing the differentially expressed proteins by isobaric tags for relative and absolute quantification(iTRAQ) combined with LC-MS/MS. After sweating, the content of total triterpene saponins decreased manifestly, while that of asperosaponin Ⅵ increased significantly. As revealed by the iTRAQ-LC-MS/MS analysis, 140 proteins with significant differential expression were figured out, with 50 up-regulated and 90 down-regulated. GO analysis indicated a variety of hydrolases, oxido-reductases, and transferases in the differential proteins. The results of activity test on two differentially expressed oxido-reductases were consistent with those of the iTRAQ-LC-MS/MS analysis. As demonstrated by the analysis of enzymes related to the triterpene saponin biosynthesis pathway, two enzymes(from CYP450 and UGT families, respectively, which are involved in the structural modification of triterpene saponins) were significantly down-regulated after sweating. The findings suggested that sweating of D. asper presumedly regulated triterpene saponins by affecting the expression of downstream CYP450 s and UGTs in the biosynthesis pathway of triterpene saponins of D. asper.


Assuntos
Dipsacaceae , Saponinas , Triterpenos , Cromatografia Líquida , Humanos , Sudorese , Espectrometria de Massas em Tandem
3.
Soft Matter ; 17(35): 8022-8026, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-34525157

RESUMO

Are aluminium ions unavoidable in antiperspirants? To answer this question, we present confocal microscopy images of dendritic plugs appearing in sweat flowing across a microfluidic channel in the presence of aluminium salts. By comparing with numerical simulations, we identify the mechanisms forming this structured protein gel inside the pore.


Assuntos
Alumínio , Suor , Antiperspirantes , Sais , Sudorese
4.
Ther Umsch ; 78(8): 473-481, 2021.
Artigo em Alemão | MEDLINE | ID: mdl-34555973

RESUMO

Evidence-based Facts of non-hormonal treatment of menopausal symptom Abstract. Menopausal symptoms like hot flushes and night sweats can have a great impact on quality of life. As first line, hormonal therapy with estrogens in combination with progestins is used, and shows beneficial effects on these symptoms. Some women, however, have contraindications against hormonal therapy or do not wish to take hormones at all. In these women, alternative treatments are needed to treat vasomotor symptoms. Pharmacologic substances like antidepressants, anticonvulsants or antihypertensive drugs show a significant reduction of these symptoms in menopausal women. Phytopharmaceutical products may show beneficial effects but study designs often do not fulfil strict scientific criteria. Furthermore, dosage and composition of the products may differ considerably. Best data are available for isoflavons and extracts of cimicifuga racemosa. Other alternative therapies like yoga, exercise, hypnosis and acupuncture showed promising results in small studies and may be recommended individually.


Assuntos
Qualidade de Vida , Sudorese , Exercício Físico , Feminino , Fogachos/tratamento farmacológico , Humanos , Menopausa
5.
BMC Womens Health ; 21(1): 293, 2021 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-34372846

RESUMO

BACKGROUND: To investigate the relationship between sweating from hot flashes, anxiety, depression, and sleep quality in peri- and postmenopausal women. And also the role of anxiety and depression in mediating sweating from hot flashes and sleep quality. METHODS: 467 women aged 40-60 years with menopausal problems were enrolled. The sleep quality; hot flashes; sweating; anxiety and depression symptoms were quantitatively evaluated by Pittsburgh Sleep Quality Scale (PSQI), Kupperman Menopause Index, Self-rating Anxiety Scale and Self-rating Depression Scale. Spearman correlation analysis and mediating effect model were used to analyze the relationship between the three. RESULTS: 262 patients' PSQI score were higher than 6 (58.2%). Total scores of sleep quality were positively correlated with hot flashes, sweating and anxiety and depression symptoms. Anxiety and depression played a mediating role between hot flashes, sweating and sleep quality where the mediating effect of anxiety symptoms accounted for 17.86% (P < 0.01) and depression symptoms accounted for 5.36% (P < 0.01). CONCLUSIONS: The hot flashes, sweating, anxiety and depression of peri/postmenopausal women are risk factors affecting sleep quality. By alleviating these risk factors, the sleep quality of peri- and postmenopausal women could be improved, which prevents the physical and mental diseases due to long-term severe insomnia.


Assuntos
Fogachos , Sudorese , Ansiedade , Feminino , Humanos , Menopausa , Perimenopausa , Pós-Menopausa , Sono
6.
Nutrients ; 13(8)2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34444723

RESUMO

There is a paucity of research examining hydration and nutrition behaviors in youth American football players. A potentially unique risk factor are league restrictions based on weight (WR) or age (AR). The purpose of this study was to examine hydration status between WR and AR leagues. The secondary purpose was to describe eating patterns in players. An observational cohort design with 63 youth football players (10 ± 1 yrs, 148.2 ± 9.4 cm, 44.9 ± 15.3 kg) was utilized. Independent variables were league (AR (n = 36); WR (n = 27)) and activity type (practice (PX = 8); game (GM = 3)). Dependent variables were hydration status (urine osmolality; percent change in body mass (%BM)), eating attitudes (Children's Eating Attitude Test (ChEAT-26)) and self-reported frequency of meals. On average, players arrived activity mildly hypohydrated (830 ± 296 mOsm/kg) and %BM was minimal (-0.1 ± 0.7%) during events. Players consumed 2 ± 1 meals and 1 ± 1 snack before events. The ChEAT-26 survey reported 21.6% (n = 8) of players were at risk for abnormal eating attitudes. Among these players, eating binges, vomiting, excessive exercise and drastic weight loss were reported. Youth American football players arrived activity mildly hypohydrated and consumed enough fluid during activity to maintain euhydration. Abnormal eating attitudes and the use of unhealthy weight loss methods were reported by some youth American football players.


Assuntos
Peso Corporal , Ingestão de Líquidos , Comportamento Alimentar , Futebol Americano , Esportes Juvenis , Adolescente , Atitude , Criança , Estudos Transversais , Comportamento de Ingestão de Líquido , Transtornos da Alimentação e da Ingestão de Alimentos/etiologia , Humanos , Masculino , Refeições , Fatores de Risco , Sudorese , Estados Unidos , Perda de Peso
7.
Rev Med Suisse ; 17(745): 1289-1294, 2021 Jul 14.
Artigo em Francês | MEDLINE | ID: mdl-34264030

RESUMO

Sweat is a body fluid produced by the sweat glands and is mainly composed of water. Sweat has various functions, the two main ones being the evacuation of heat produced by the body, especially during exercise, and the maintenance of skin homeostasis. Its production is highly variable and depends on many individual and environmental factors. Various diseases or conditions affect its proper functioning. This article presents an overview of the characteristics, the main health issues, and the current and potential applications related to sweat.


Assuntos
Suor , Sudorese , Exercício Físico , Temperatura Alta , Humanos , Pele
8.
J Sports Sci Med ; 20(3): 448-456, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34267584

RESUMO

Sweating during exercise is regulated by objective parameters, body weight, and endothelial function, among other factors. However, the relationship between vascular arterial stiffness and sweat volume in young adults remains unclear. This study aimed to identify hemodynamic parameters before exercise that can predict sweat volume during exercise, and post-exercise parameters that can be predicted by the sweat volume. Eighty-nine young healthy subjects (aged 21.9 ± 1.7 years, 51 males) were recruited to each perform a 3-km run on a treadmill. Demographic and anthropometric data were collected and hemodynamic data were obtained, including heart rate, blood pressure and pulse wave analysis using non-invasive tonometry. Sweat volume was defined as pre-exercise body weight minus post-exercise body weight. Post-exercise hemodynamic parameters were also collected. Sweat volume was significantly associated with gender, body surface area (BSA) (b = 0.288, p = 0.010), peripheral systolic blood pressure (SBP), peripheral and central pulse pressure (PP), and was inversely associated with augmentation index at an HR of 75 beats/min (AIx@HR75) (b = -0.005, p = 0.019) and ejection duration. While BSA appeared to predict central PP (B = 19.271, p ≤ 0.001), central PP plus AIx@HR75 further predicted sweat volume (B = 0.008, p = 0.025; B = -0.009, p = 0.003 respectively). Sweat volume was associated with peripheral SBP change (B = -17.560, p = 0.031). Sweat volume during a 3-km run appears to be influenced by hemodynamic parameters, including vascular arterial stiffness and central pulse pressure. Results of the present study suggest that vascular arterial stiffness likely regulates sweat volume during exercise.


Assuntos
Hemodinâmica , Corrida/fisiologia , Sudorese/fisiologia , Pressão Sanguínea , Superfície Corporal , Feminino , Frequência Cardíaca , Humanos , Masculino , Estudos Prospectivos , Fatores Sexuais , Volume Sistólico , Suor , Rigidez Vascular , Adulto Jovem
9.
J Neurol Sci ; 428: 117589, 2021 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-34325159

RESUMO

Treatment related fluctuations (TRFs) in Guillain-Barré Syndrome (GBS) are described as one or more episodes of deterioration manifesting within two months after disease onset and following an initial improvement or stabilisation after treatment. They may be encountered in 8% to 16% of patients, but currently predictive factors of TRF occurrence and severity are poorly known. To this end, we evaluated the frequency and clinical features of TRFs in a cohort of GBS patients admitted to the Neurological unit of Sant'Andrea Hospital (La Spezia, Italy) from January 1st, 2003 to December 31st, 2017. Among the 98 GBS collected patients, five (5.1%) developed a TRF during disease course. Consistently with the literature, the majority of our GBS patients who developed a TRF did not report a preceding diarrhoea, had a predominant proximal weakness and all of them had sensory disturbances at the clinical onset. Interestingly, 80% of our TRF patients manifested since GBS onset an autonomic dysfunction with abnormal sweating and a peculiar 'skin flushing' in face, neck and chest. Two patients developed respiratory insufficiency at the TRF time, and they both died. We would advise to pay attention to GBS patients with particular 'skin flushing' in face, neck and chest and abnormal sweating, because these findings could be a red flag for TRF.


Assuntos
Síndrome de Guillain-Barré , Hiperidrose , Estudos de Coortes , Progressão da Doença , Síndrome de Guillain-Barré/complicações , Humanos , Sudorese
10.
Ann Intern Med ; 174(7): ITC97-ITC112, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34251902

RESUMO

This review focuses on the diagnosis and management of menopause, highlighting both hormonal and nonhormonal treatment options. In particular, the article focuses on recent data on the risks and benefits of hormone therapy to help clinicians better counsel their patients about decision making with regard to understanding and treating menopause symptoms.


Assuntos
Menopausa/fisiologia , Neoplasias da Mama/etiologia , Doenças Cardiovasculares/prevenção & controle , Transtornos Cognitivos/etiologia , Contraindicações de Medicamentos , Terapia de Reposição de Estrogênios/efeitos adversos , Feminino , Estilo de Vida Saudável , Fogachos/tratamento farmacológico , Fogachos/terapia , Humanos , Menopausa/sangue , Menopausa/psicologia , Osteoporose Pós-Menopausa/prevenção & controle , Educação de Pacientes como Assunto , Medição de Risco , Inibidores de Captação de Serotonina/uso terapêutico , Sudorese/fisiologia , Vagina/fisiologia , Sistema Vasomotor/fisiologia
11.
Pediatr Dermatol ; 38(4): 984-985, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34227168

RESUMO

Harlequin syndrome is a rare disorder of the autonomic nervous system, presenting as unilateral reduced flushing and sweating of the face induced by exercise, stress, or heat. It is caused by a cervical sympathetic deficit located at the preganglionic or postganglionic level on the non-flushing side. We present a case of an 8 year old with harlequin syndrome and review the other dermatological conditions for which the term "harlequin" is part of the nomenclature.


Assuntos
Doenças do Sistema Nervoso Autônomo , Hipo-Hidrose , Doenças do Sistema Nervoso Autônomo/diagnóstico , Criança , Feminino , Rubor/diagnóstico , Rubor/etiologia , Humanos , Hipo-Hidrose/diagnóstico , Sudorese
12.
Clinics (Sao Paulo) ; 76: e2892, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34190853

RESUMO

OBJECTIVES: Studies have identified correlations between the psychological characteristics of individuals with primary hyperhidrosis (HH), the degree of sweating, and the quality of life (QoL). This study aimed to evaluate the prevalence of anxiety and depression symptoms in patients with HH before and after oxybutynin treatment. METHODS: Data were collected from 81 patients. Palmar or axillary HH was the most frequent complaint (84.0%). All patients were evaluated before the medication was prescribed and after five weeks of treatment. The Beck Depression Inventory and Beck Anxiety Inventory were used to evaluate depression and anxiety. RESULTS: Improvement in HH occurred in 58 patients (71.6%), but there was no improvement in 23 patients (28.4%). The QoL before treatment in all patients was either "poor" or "very poor." Patients who experienced improvement in sweating rates also experienced a greater improvement in QoL than patients who did not experience improvement in sweating at the main site (87.9% vs. 34.7%) (p<0.001). A total of 19.7% of patients showed an improvement in their level of depression, and a total of 46.9% of patients exhibited improvements in their level of anxiety. A significant correlation was observed between sweating and anxiety (p=0.015). CONCLUSION: Patients with HH who experienced improvements in sweating immediately after treatment with oxybutynin exhibited small improvements in their levels of depression and significant improvements in their levels of anxiety and QoL.


Assuntos
Hiperidrose , Qualidade de Vida , Ansiedade , Depressão/tratamento farmacológico , Depressão/epidemiologia , Humanos , Hiperidrose/tratamento farmacológico , Ácidos Mandélicos , Antagonistas Muscarínicos , Sudorese , Resultado do Tratamento
13.
Am J Physiol Regul Integr Comp Physiol ; 321(2): R91-R99, 2021 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-34075801

RESUMO

Human thermoregulatory control is often evaluated through the relationship between thermoeffector output and core or mean body temperature. In addition to providing a general indication of whether a variable of interest alters thermoregulatory control, this relationship is often used to determine how this alteration may occur. This latter interpretation relies upon two parameters of the thermoeffector output-body temperature relationship: the onset threshold and thermosensitivity. Traditionally, changes in the onset threshold and thermosensitivity are interpreted as "central" or "peripheral" modulation of thermoregulatory control, respectively. This mini-review revisits the origins of the thermoeffector output-body temperature relationship and its use to interpret "central" or "peripheral" modulation of thermoregulatory control. Against this background, we discuss the strengths and weaknesses of this approach and highlight that "central" thermoregulatory control reflects the neural control of body temperature whereas "peripheral" thermoregulatory control reflects properties specific to the thermoeffector organs. We highlight studies that employed more direct approaches to investigate the neural control of body temperature and peripheral properties of thermoeffector organs. We conclude by encouraging future investigations interested in studying thermoregulatory control to more directly investigate the component of the thermoeffector loop under investigation.heat; human; skin blood flow; sweat; thermoregulatory.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Vasos Sanguíneos/inervação , Encéfalo/fisiologia , Temperatura Cutânea , Pele/irrigação sanguínea , Sudorese , Termorreceptores/fisiologia , Vasodilatação , Humanos , Modelos Biológicos , Fluxo Sanguíneo Regional , Sensação Térmica
14.
J Sci Med Sport ; 24(8): 774-780, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34158232

RESUMO

OBJECTIVES: To investigate the efficacy of heat acclimation (HA) in the young (YEX) and elderly (EEX) following exercise-HA, and the elderly utilising post-exercise hot water immersion HA (EHWI). DESIGN: Cross-sectional study. METHOD: Twenty-six participants (YEX: n = 11 aged 22 ±â€¯2 years, EEX:n = 8 aged 68 ±â€¯3 years, EHWI: n = 7 aged 73 ±â€¯3 years) completed two pre-/post-tests, separated by five intervention days. YEX and EEX exercised in hot conditions to raise rectal temperature (Trec) ≥38.5 °C within 60 min, with this increase maintained for a further 60 min. EHWI completed 30 min of cycling in temperate conditions, then 30 min of HWI (40 °C), followed by 30 min seated blanket wrap. Pre- and post-testing comprised 30 min rest, followed by 30 min of cycling exercise (3.5 W·kg-1 Hprod), and a six-minute walk test (6MWT), all in 35 °C, 50% RH. RESULTS: The HA protocols did not elicit different mean heart rate (HR), Trec, and duration Trec ≥ 38.5 °C (p > 0.05) between YEX, EEX, and EHWI groups. Resting Trec, peak skin temperature, systolic and mean arterial pressure, perceived exertion and thermal sensation decreased, and 6MWT distance increased pre- to post-HA (p < 0.05), with no difference between groups. YEX also demonstrated a reduction in resting HR (p < 0.05). No change was observed in peak Trec or HR, vascular conductance, sweat rate, or thermal comfort in any group (p > 0.05). CONCLUSIONS: Irrespective of age or intervention, HA induced thermoregulatory, perceptual and exercise performance improvements. Both exercise-HA (EEX), and post-exercise HWI (EHWI) are considered viable interventions to prepare the elderly for heat stress.


Assuntos
Aclimatação , Envelhecimento/fisiologia , Exercício Físico/fisiologia , Resposta ao Choque Térmico , Temperatura Alta , Imersão , Idoso , Pressão Sanguínea , Estudos Transversais , Feminino , Frequência Cardíaca , Transtornos de Estresse por Calor/prevenção & controle , Humanos , Masculino , Percepção/fisiologia , Esforço Físico/fisiologia , Descanso , Temperatura Cutânea , Sudorese , Sensação Térmica , Adulto Jovem
15.
J Sci Med Sport ; 24(8): 763-767, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34175201

RESUMO

The objective was to compare the efficacy of three different heat acclimation protocols to improve exercise performance in the heat. Thirty four cyclists completed one of three 10-day interventions 1) 50-min cycling per day in 35 °C, 2) 50-min cycling per day wearing thermal clothing, and 3) 50-min cycling wearing thermal clothing plus 25 min hot water immersion per day. Pre- and post-intervention hemoglobin mass, intravascular volumes and core temperature were determined at rest. Heart rate, sweat rate, blood lactate concentration and core temperature were evaluated during 15-min submaximal and 30-min all-out cycling performance conducted in 35.2 ±â€¯0.1 °C and 61 ±â€¯1% relative humidity. There were no significant between-group differences in any of the determined variables. None of the interventions statistically altered any of the parameters investigated as part of the 15-min submaximal trial. However, following the intervention period, heat chamber, thermal clothing and thermal clothing + hot water immersion all improved 30-min all-out average power in the heat (9.5 ±â€¯3.8%, 9.5 ±â€¯3.6 and 9.9 ±â€¯5.2%, respectively, p < 0.001, F = 192.3). At termination of the 30-min all-out test, the increase in blood lactate concentration, rate of perceived exertion and sweat rate were not different between the three interventions. In conclusion, daily training sessions conducted either in ambient 35 °C, while wearing thermal clothing in temperate conditions or while wearing thermal clothing combined with hot water immersion are equally effective for improving exercise performance in the heat.


Assuntos
Aclimatação , Vestuário , Temperatura Alta , Condicionamento Físico Humano/métodos , Condicionamento Físico Humano/fisiologia , Ciclismo/fisiologia , Volume Sanguíneo , Feminino , Frequência Cardíaca , Hematócrito , Hemoglobinometria , Humanos , Imersão , Ácido Láctico/sangue , Masculino , Percepção/fisiologia , Esforço Físico/fisiologia , Sudorese , Fatores de Tempo , Adulto Jovem
16.
J Sci Med Sport ; 24(8): 843-850, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34175202

RESUMO

OBJECTIVES: We performed a systematic review and meta-analysis to examine the effect of body fat on thermoregulatory responses to exercise in the heat. DESIGN: Systematic Review and Meta-analysis. METHODS: We systematically searched databases (N = 8) for studies that included: healthy participants; an aerobic exercise intervention under heat stress; a measure of body fat by a high and low body fat group; pre- and post-exercise internal temperature, and/or post-exercise mean skin temperature and whole body sweat loss. Criteria to distinguish high body fat and low body fat were determined by each qualifying study. Out of 1222 potential studies, 10 qualified. Robust variance estimation models were utilized to determine the pooled effect size (ES, 95% CI) for interventions that performed unbias comparisons between groups. RESULTS: Participants (n = 211) were mostly male (70%) and young (19.3 ±â€¯7.1 years) with a maximal oxygen consumption of 50.42 ±â€¯9.3 ml∙kg-1∙min-1 by high body fat (36.7 ±â€¯11.8%) and low body fat (17.8 ±â€¯5.7%). Exercise duration was between 30 and 60 min at moderate-high intensity (44.1-71.4% VO2max) at 28-40.3 °C and 26-50% humidity. Of the 7 interventions that normalized metabolic heat production to body mass and 5 interventions that normalized to external workload, there were no differences in any of the three outcome variables between groups. CONCLUSIONS: Many of the included studies did not control for confounding factors that may affect the relationship between body fat and thermoregulation during exercise in the heat such as metabolic heat production and body mass. Given the small number of interventions included, future work must make unbiased comparisons to appropriately assess the independent influence of body fat.


Assuntos
Distribuição da Gordura Corporal , Regulação da Temperatura Corporal , Exercício Físico/fisiologia , Temperatura Alta , Resposta ao Choque Térmico , Humanos , Projetos de Pesquisa , Temperatura Cutânea , Sudorese
17.
Breast Cancer Res Treat ; 188(2): 343-350, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34159473

RESUMO

PURPOSE: Vasomotor symptoms (VMS) such as hot flashes and night sweats are common in breast cancer patients and can affect both quality of life and treatment adherence. However, there is limited practical data to guide clinicians in the optimal selection of therapeutic strategies. A survey of health care providers was performed to better understand perspectives and prescribing practices for managing this problem. METHODS: Canadian health care providers who treat patients with early stage breast cancer (EBC) participated in an anonymous electronic survey. Participants provided their perspectives on the prevalence and severity of VMS among patients with EBC, outlined their management strategies, and provided feedback on the perceived efficacy of interventions for VMS. RESULTS: Responses were received from 65 providers including breast oncologists (36/65, 55%) and nurses with oncology expertise (29/65, 45%). Seventy-seven percent of participants reported regularly asking patients about VMS, and most indicated that bothersome VMS occurred in the majority of patients. Health care providers cited hot flash severity and sleep disruption as the most important issues for patients. The most common first- and second-line interventions recommended were lifestyle modifications (n = 32/65, 49.2%) and pharmacologic strategies (n = 27/65, 41.5%), respectively. Most respondents felt that interventions, including pharmacologic, over-the-counter, and complementary therapies, were only "somewhat effective". Overall, half of respondents (n = 35/65, 54%) reported being "confident" in managing VMS. CONCLUSION: Given the variability of treatment recommendations, and health care provider uncertainty around the benefits of therapies for VMS, more 'real-world' trials are needed to optimize patient care.


Assuntos
Neoplasias da Mama , Menopausa , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/epidemiologia , Canadá , Feminino , Pessoal de Saúde , Fogachos/epidemiologia , Fogachos/etiologia , Fogachos/terapia , Humanos , Qualidade de Vida , Inquéritos e Questionários , Sudorese
18.
Menopause ; 28(8): 875-882, 2021 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-34033602

RESUMO

OBJECTIVE: To determine prevalence and health-related quality of life (HRQOL) of moderate-to-severe vasomotor symptoms (VMS) in postmenopausal women in Europe, the US, and Japan, and among subgroups of women not taking hormone therapy (HT). METHODS: Screening surveys were sent to a random sample of women aged 40 to 65 years; full questionnaires followed to those who completed them and met inclusion criteria. Women with successfully treated VMS, breast cancer, or on HT for medical conditions were excluded. The Menopause-Specific QOL (MENQOL) and Work Productivity and Activity Impairment (WPAI) questionnaires were included in the questionnaire. RESULTS: Of 25,161 women completing the screening survey, 11,771 were postmenopausal and 3,460 met inclusion criteria and completed the full questionnaire. Prevalence of moderate-to-severe VMS was 40%, 34%, and 16% in Europe, the US, and Japan, respectively. A large proportion were HT averse, albeit eligible (Europe 56%, US 54%, Japan 79%). In total, 12%, 9%, and 8% in Europe, the US, and Japan, respectively, were HT-contraindicated. A high proportion were HT-cautious (Europe 70%, US 69%, Japan 52%). Most common menopausal symptoms reported in the MENQOL were feeling tired or worn out (Europe/US 74%, Japan 75%), aching in muscles and joints (Europe 69%, US 68%, Japan 61%), difficulty sleeping (Europe 69%, US 66%, Japan 60%), and hot flashes (Europe 67%, US 68%, Japan 62%). Overall, the most bothersome symptom was weight gain. As measured by the WPAI, hot flashes and night sweats had a greater impact on daily activities than on working activities. CONCLUSIONS: A high proportion of women experienced moderate-to-severe VMS, with associated symptoms impacting QOL.


Assuntos
Menopausa , Qualidade de Vida , Estudos Transversais , Feminino , Fogachos/epidemiologia , Humanos , Prevalência , Inquéritos e Questionários , Sudorese
19.
J Appl Physiol (1985) ; 131(2): 520-531, 2021 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-34043472

RESUMO

Seasonal acclimatization from winter to summer is known to enhance thermoeffector responses in hot-dry environments during exercise whereas its impact on sweat evaporation and core temperature (Tcore) responses in hot-humid environments remains unknown. We, therefore, sought to determine whether seasonal acclimatization is able to modulate whole body sweat rate (WBSR), evaporated sweat rate, sweating efficiency, and thermoregulatory function during cycling exercise in a hot-humid environment (32°C, 75% RH). We also determined whether the increase in air velocity could enhance evaporated sweat rate and sweating efficiency before and after seasonal acclimatization. Twelve males cycled for 1 h at 40% V̇o2max in winter (preacclimatization) and repeated the trial again in summer (after acclimatization). For the last 20 min of cycling at a steady-state of Tcore, air velocity increased from 0.2 (0.04) m/s to 1.1 (0.02) m/s by using an electric fan located in front of the participant. Seasonal acclimatization enhanced WBSR, unevaporated sweat rate, local sweat rate and mean skin temperature compared with preacclimatization state (all P < 0.05) whereas sweating efficiency was lower (P < 0.01) until 55 min of exercise. Tcore and evaporated sweat rate were unaltered by acclimatization status (all P > 0.70). In conclusion, seasonal acclimatization enhances thermoeffector responses but does not attenuate Tcore during exercise in a hot-humid environment. Furthermore, increasing air velocity enhances evaporated sweat rate and sweating efficiency irrespective of acclimated state. NEW & NOTEWORTHY Seasonal acclimatization to humid heat enhances eccrine sweat gland function and thus results in a higher local and whole body sweat rate but does not attenuate Tcore during exercise in a hot-humid environment. Sweating efficiency is lower after seasonal acclimatization to humid heat compared with preacclimatization with and without the increase of air velocity. However, having a lower sweating efficiency does not mitigate the Tcore response during exercise in a hot-humid environment.


Assuntos
Temperatura Corporal , Temperatura Alta , Aclimatação , Regulação da Temperatura Corporal , Humanos , Umidade , Masculino , Estações do Ano , Sudorese
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