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Rev Med Chir Soc Med Nat Iasi ; 96(1-2): 57-64, 1992.
Artigo em Romano | MEDLINE | ID: mdl-1410926


Cicatrol ointment with the formula: argentic sulphamethoxydiasine 1 g, bentonite hydrogel 12.5% for 100 g is manufactured at the Microproduction Laboratory of the Faculty of Pharmacy of Iasi. The one-year physicochemical determinations of the aspect, colour, homogeneity, pH, rheological behaviour and relative viscosity, content in argentic sulphamethoxydiasine as well as "in vitro" antimicrobial activity of Cicatrol showed a good stability and gel properties enabling an uniform and long-term contact with the wound. The clinical investigations carried out until now in patients with burns, varicose ulcers, trophic shank ulcers, superficial phlebitis with atonic ulcerations or wounds with multiple sites revealed its remarkable therapeutic value. As compared to other similar products, Cicatrol by its aseptic properties favours the scarring of any type of wound, a normal skin, without keloid scars being obtained, it also being well tolerated.

Ácido Pantotênico/química , Sulfameter/química , Queimaduras/tratamento farmacológico , Carboximetilcelulose Sódica , Fenômenos Químicos , Físico-Química , Combinação de Medicamentos , Avaliação de Medicamentos , Estabilidade de Medicamentos , Glicerol , Humanos , Concentração de Íons de Hidrogênio , Úlcera da Perna/tratamento farmacológico , Testes de Sensibilidade Microbiana , Pomadas , Ácido Pantotênico/farmacologia , Ácido Pantotênico/uso terapêutico , Compostos de Prata , Sulfameter/farmacologia , Sulfameter/uso terapêutico , Úlcera Varicosa/tratamento farmacológico , Viscosidade
Rev. peru. med. trop ; 5: 31-9, 1991. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-121589


De 11 casos estudiados entre los años 1976 y 1986 en el Consultorio Externo del Instituto de Medicina Tropical, se presentan 7 con diagnóstico etiológico y con el objetivo de ahondar en el conocimiento y detección de la Blastomicosis Sudamericana de importante incidencia en nuestro país. Se señalan las variantes epidemiológicas y clínicas, los medios de diagnóstico utilizados y el tratamiento que tentativamente se ha aplicado

Humanos , Masculino , Pessoa de Meia-Idade , Blastomicose/terapia , Paracoccidioidomicose/epidemiologia , Gastroenterite/diagnóstico , Cetoconazol/uso terapêutico , Pneumopatias Fúngicas/etiologia , Paracoccidioidomicose/epidemiologia , Peru , Sulfameter/uso terapêutico
Wien Klin Wochenschr ; 93(3): 93-6, 1981 Feb 06.
Artigo em Alemão | MEDLINE | ID: mdl-7245778


Two newborn infants with congenital toxoplasmosis despite serological testing during pregnancy were observed at our premature and neonatal intensive care unit within a short time of one another. In one case the counter-regulatory late first test, performed only in the 26th week, was positive with a high titre. The immediately recommended treatment was not carried out. Apart from the signs of congenital generalized infection, the newborn infant already manifested chorioretinitis and encephalitis. In the second case the initially serologically-negative pregnant women became infected only during the 35th to 36th week of gestation, around the time of the third serological examination. The child was born with slight signs of general infection, but without CNS involvement. Immediate postnatal treatment resulted in complete cure. This shows that such rare cases which can no longer be detected by serological testing can be treated postnatally with good results.

Toxoplasmose Congênita/diagnóstico , Adulto , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , Complicações Infecciosas na Gravidez/diagnóstico , Pirimetamina/uso terapêutico , Sulfameter/uso terapêutico , Toxoplasmose Congênita/tratamento farmacológico
Wien Klin Wochenschr ; 90(1): 25-9, 1978 Jan 06.
Artigo em Alemão | MEDLINE | ID: mdl-625985


White mice infected intraperitoneally with the RH-strain of Toxoplasma gondii (inoculum size 50,000 to 100,000 free protozoans per mouse) received treatment between the second and eighth day after infection with sulphamethazine-pyrimethamine, sulphamethoxy-diazine-pyrimethamine, trimethoprim-sulphamethoxazole or spiramycin subcutaneously. All untreated controls and all mice of the trimethoprim-sulphamethoxazole and spiramycin-treated groups died during the acute stage (except two mice in the latter group on the 15th day). The mean survival times were 6.5, 7.5 and 7.6 days, respectively. The best results were obtained in the sulphamethazine-pyrimethamine-treated mice; 18 out of 27 survived the 30-day observation period (5 cured), in contrast to only 9 out of 40 sulphamethoxydiazine-pyrimethamine-treated mice. Considering the high pathogenicity of the RH-strain, the differences in immunological defence mechanisms in mice (absence of antibody-activating "accessory factor") and the late commencement of treatment of the infected mice, one can state that the combination of sulphamethoxydiazine-pyrimethamine should also be capable of overcoming acute human toxoplasmosis in pregnancy. Spiramycin, by contrast, should be given only in cases where sulphonamide intolerance exists and must then be given in high doses until delivery. The combination of sulphamethoxazole-trimethoprim cannot be recommended.

Leucomicinas/uso terapêutico , Pirimetamina/uso terapêutico , Sulfameter/uso terapêutico , Sulfametazina/uso terapêutico , Sulfametoxazol/uso terapêutico , Sulfanilamidas/uso terapêutico , Toxoplasmose Animal/tratamento farmacológico , Trimetoprima/uso terapêutico , Animais , Injeções Subcutâneas , Leucomicinas/administração & dosagem , Camundongos , Pirimetamina/administração & dosagem , Sulfameter/administração & dosagem , Sulfametazina/administração & dosagem , Sulfametoxazol/administração & dosagem , Trimetoprima/administração & dosagem
Artigo em Romano | MEDLINE | ID: mdl-653217


A case of chickenpox associated with Lyell syndrome, which appeared after the administration of sulfamethine, is reported. Quantitative determination of the immunoglobulins showed marked immunologic changes in the course of the syndrome. Antistaphylococcal treatment, without corticotherapy led to clinical recovery.

Varicela/complicações , Síndrome de Stevens-Johnson/complicações , Sulfameter/efeitos adversos , Sulfanilamidas/efeitos adversos , Varicela/imunologia , Pré-Escolar , Tosse/tratamento farmacológico , Humanos , Masculino , Síndrome de Stevens-Johnson/imunologia , Sulfameter/uso terapêutico