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1.
Medicine (Baltimore) ; 99(5): e18909, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32000395

RESUMO

BACKGROUND: The prolonged culture of embryos to the blastocyst stage represents an increasing procedure in Assisted Reproductive Technology (ART) laboratories. Generally, only blastocysts developing on Day 5 and Day 6 are considered suitable embryos for transfer, cryopreservation or biopsy while embryos developed at a slower rate after Day 6 are routinely discarded. However, also blastocysts developing on Day 7 can be viable and result in a healthy live birth. Unfortunately, data regarding the clinical outcomes of Day 7 blastocysts compared to blastocysts developing on Day 5 or Day 6 are controversial. In this systematic review and aggregate data meta-analysis, we aim to evaluate the real reproductive potential of delayed blastocysts on Day 7 in frozen cycles. METHODS: We will include all studies, with no restriction regarding the study design (randomized and observational trials, including cohort and case-control), investigating the clinical success of blastocysts developed on Day 7 compared to Day 5 and Day 6 blastocysts. The primary outcomes are the clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) following frozen-thawed embryo transfer (Day 7 vs Day 6, and Day 5); secondary outcomes are: live birth rate (LBR) following frozen-thawed embryo transfer, euploid rate and survival rate of thawed blastocyst. Two reviewers independently will judge the methodological quality of studies included in the meta-analysis using the criteria reported in the Cochrane Handbook for Systematic Reviews of Interventions or the Newcastle-Ottawa Scale according to the design of the trials. The meta-analysis will be performed using random effects models and heterogeneity will be assessed using Higgins I2 value. Summary estimate of the proportion of each outcome will be expressed as pooled proportion with 95% confidence interval (CI). The effect of the day on each outcome will be evaluated using a multilevel mixed-effects model with a moderator (the day). The effect will be expressed as odds ratio (OR) with 95% confidence interval (CI). A P value less than .05 will be considered statistically significant. ETHICS AND DISSEMINATION: This is a systematic review not requiring an ethical approval. Findings derived from this systematic review and meta-analysis will be published in a peer-reviewed journal.


Assuntos
Técnicas de Cultura Embrionária , Técnicas de Reprodução Assistida , Humanos , Metanálise como Assunto , Revisão Sistemática como Assunto
2.
J Forensic Leg Med ; 69: 101891, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32056807

RESUMO

In Italy, the law n. 40 of 2004 (Norms in matter of medically assisted procreation), allows to access to the techniques of Medically assisted Procreation (MAP) exclusively to couples formed by two individuals of different sex. On the basis of this law, two couples of homosexual women were prohibited from using MAP techniques. For this reason, the couples have appealed to the competent courts that have raised doubts of constitutional legitimacy. In June 2019, the Italian Constitutional Court stated that it is not illegal to prohibit gay couples from accessing MAP techniques. In October 2019, the judgment No. 221, in which this decision is based, was published. Following the publication of the judgment, a bioethical-legal debate arose on this issue: is this a discrimination, or a simple limit based on medical-legal criteria?


Assuntos
Homossexualidade Feminina , Homossexualidade Masculina , Técnicas de Reprodução Assistida/legislação & jurisprudência , Feminino , Humanos , Itália , Masculino
3.
Sheng Li Xue Bao ; 72(1): 125-132, 2020 Feb 25.
Artigo em Chinês | MEDLINE | ID: mdl-32099990

RESUMO

In recent years, it has been found that kisspeptin plays some key roles in the physiological processes of the brain, such as gender differentiation, positive and negative feedback of sex hormones, onset of puberty, and transduction of energy signals in the body, which suggests that kisspeptin may be a key molecule for the maturation and regulation of female reproductive function. In addition to the systemic roles of the kisspeptin, its local roles in reproductive organs are constantly being discovered. With the discovery that kisspeptin is involved in the pathological process of reproductive endocrine diseases such as isolated hypogonadotropic hypogonadism (IHH), polycystic ovary syndrome (PCOS), premature ovarian failure (POF) and pathological hyperprolactinemia, exogenous application of kisspeptin to solve reproductive problems has become a new hot topic. The review focuses on the research progress of kisspeptin in the female reproductive system, especially on its application in assisted reproduction.


Assuntos
Kisspeptinas/fisiologia , Técnicas de Reprodução Assistida , Feminino , Hormônios Esteroides Gonadais/fisiologia , Humanos , Hiperprolactinemia/fisiopatologia , Hipogonadismo/fisiopatologia , Kisspeptinas/farmacologia , Síndrome do Ovário Policístico/fisiopatologia , Gravidez , Insuficiência Ovariana Primária/fisiopatologia
4.
Int J Cancer ; 146(3): 829-838, 2020 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-30989639

RESUMO

Advances in multimodality cancer treatments have increased the risk of long-term complications in early-onset cancer survivors. For female cancer survivors, these include diminished reproductive function, often resulting in a narrowed fertile window. The aim of our study was to evaluate the use of fertility treatments in cancer survivors (aged 0-39 years at diagnosis) compared to siblings. Data from Finnish registers on cancer, birth and prescribed medications were merged to identify 8,929 survivors and 9,495 siblings without previous deliveries. Fertility drug purchases from 1993 to 2012 at the age of 16-41 years were included. A Poisson regression model was used to estimate incidence rate ratios (IRRs) for the use of fertility drugs, adjusting for age and calendar time at fertility drug purchase. Fertility treatments were more common in survivors compared to siblings, as 6.1% of survivors compared to 3.8% of siblings had bought fertility drugs (IRR 1.43, 95% confidence interval [CI] 1.25-1.65). A subclassification of fertility treatments into ovulation inductions and assisted reproductive technology (ART), showed increased use of ART (IRR 2.41, 95% CI 1.97-2.96), whereas the use of ovulation induction was similar in survivors and siblings. Analyses by calendar time periods showed the use of ART to be significantly higher in the most recent decade, from 2003 onwards. We conclude that cancer survivors have an increased risk for subfertility, which is why fertility counseling is important. However, our results mirror a more active approach among clinicians towards fertility treatments in cancer survivors during the most recent years.


Assuntos
Sobreviventes de Câncer/estatística & dados numéricos , Fármacos para a Fertilidade/uso terapêutico , Infertilidade Feminina/terapia , Neoplasias/complicações , Adolescente , Adulto , Antineoplásicos/efeitos adversos , Estudos de Casos e Controles , Criança , Pré-Escolar , Prescrições de Medicamentos/estatística & dados numéricos , Feminino , Fertilidade/efeitos dos fármacos , Fertilidade/efeitos da radiação , Finlândia , Humanos , Lactente , Recém-Nascido , Infertilidade Feminina/etiologia , Masculino , Neoplasias/mortalidade , Neoplasias/terapia , Gravidez , Radioterapia/efeitos adversos , Sistema de Registros/estatística & dados numéricos , Técnicas de Reprodução Assistida/estatística & dados numéricos , Irmãos , Adulto Jovem
5.
BJOG ; 127(2): 230-238, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31397072

RESUMO

Women with congenital absolute uterine factor infertility (AUFI) often need vaginal restoration to optimise sexual function. Given their lack of procreative ability, little consideration has previously been given to the resultant vaginal microbiome (VM). Uterine transplantation (UTx) now offers the opportunity to restore these women's reproductive potential. The structure of the VM is associated with clinical and reproductive implications that are intricately intertwined with the process of UTx. Consideration of how vaginal restoration methods impact VM is now warranted and assessment of the VM in future UTx procedures is essential to understand the interrelation of the VM and clinical and reproductive outcomes. TWEETABLE ABSTRACT: The vaginal microbiome has numerous implications for clinical and reproductive outcomes in the context of uterine transplantation.


Assuntos
Anormalidades Congênitas/cirurgia , Infertilidade Feminina/cirurgia , Microbiota/fisiologia , Transplante de Órgãos , Útero/transplante , Vagina/microbiologia , Feminino , Humanos , RNA Ribossômico 16S/fisiologia , Técnicas de Reprodução Assistida , Útero/anormalidades , Útero/microbiologia , Vagina/fisiopatologia
6.
JAMA ; 322(22): 2203-2210, 2019 12 10.
Artigo em Inglês | MEDLINE | ID: mdl-31821431

RESUMO

Importance: An increasing number of children worldwide are born after the use of fertility treatment, although it remains unclear whether the treatment affects the risk of childhood cancer and whether any associations observed are due to the use of specific drugs, the use of specific procedures, or the underlying infertility. Objective: To examine the association between different types of fertility treatments and cancer risk in children. Design, Setting, and Participants: A retrospective cohort study based on Danish population-based registry data and the Danish Infertility Cohort (individual record linkage) that included 1 085 172 children born in Denmark between January 1, 1996, and December 31, 2012, linked with parental information. There were a total of 2217 children diagnosed with cancer (follow-up occurred during 1996-2015). Exposures: Maternal fertility treatment during the index pregnancy, including the use of fertility drugs (clomiphene [n = 33 835], gonadotropins [n = 57 136], gonadotropin-releasing hormone analogs [n = 38 653], human chorionic gonadotropin [n = 68 181], progesterone [n = 41 628], and estrogen [n = 16 948]) and assisted reproductive technology (in vitro fertilization [n = 19 448], intracytoplasmic sperm injection [n = 13 417], and frozen embryo transfer [n = 3356]). Each exposure was examined separately and compared with children born to fertile women. Main Outcomes and Measures: Hazard ratios and incidence rate differences for childhood cancer. Results: After 12.2 million person-years of follow-up (mean, 11.3 years), the incidence rate of childhood cancer was 17.5 per 100 000 for children born to fertile women (n = 910 291) and 44.4 per 100 000 for children born after the use of frozen embryo transfer (n = 3356). Compared with children born to fertile women, the use of frozen embryo transfer was associated with an elevated risk of childhood cancer (14 cancer cases; hazard ratio, 2.43 [95% CI, 1.44 to 4.11]; incidence rate difference, 26.9 [95% CI, 2.8 to 51.0] per 100 000), mainly due to an increased risk of leukemia (5 cancer cases; incidence rate, 14.4 per 100 000; hazard ratio, 2.87 [95% CI, 1.19 to 6.93]; incidence rate difference, 10.1 [95% CI, -4.0 to 24.2] per 100 000) and sympathetic nervous system tumors (<5 cancer cases; hazard ratio, 7.82 [95% CI, 2.47 to 24.70]). There were no statistically significant associations with the use of the other types of fertility treatment examined. Conclusions and Relevance: Among children born in Denmark, the use of frozen embryo transfer, compared with children born to fertile women, was associated with a small but statistically significant increased risk of childhood cancer; this association was not found for the use of other types of fertility treatment examined.


Assuntos
Transferência Embrionária/efeitos adversos , Neoplasias/etiologia , Técnicas de Reprodução Assistida , Adulto , Criança , Estudos de Coortes , Dinamarca/epidemiologia , Feminino , Fármacos para a Fertilidade Feminina/efeitos adversos , Fertilização In Vitro , Humanos , Incidência , Masculino , Neoplasias/epidemiologia , Gravidez , Técnicas de Reprodução Assistida/efeitos adversos , Estudos Retrospectivos , Fatores de Risco , Fatores Socioeconômicos , Injeções de Esperma Intracitoplásmicas
7.
Arch Esp Urol ; 72(10): 1038-1042, 2019 Dec.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31823853

RESUMO

OBJECTIVES: To evaluate the impact of common Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene mutations, 5T polymorphism and presence of severe Cystic Fibrosis (CF) on fertility outcomes with Assisted Reproductive Techniques (ART) in patients presenting Congenital Bilateral Absence of Vas Deferens (CBAVD). METHODS: A comparative observational cohort study was performed from 2002 to 2018 with 51 patients with diagnosis of CBAVD. Presence of CFTR mutations and 5T, CF, pregnancy and newborn rates were analyzed. RESULTS: 80.4% percent had some mutation of CFTR gene being ΔF508 the most common (51%). The most frequently described genotype was the 7T/9T (31.4%) with the presence of 5T polymorphism in up to 25.5% of cases. Global newborn rates were 34% in the group using partner spermatozoa. When comparing 5T presence, we observed a decrease in newborn rates when carrying this mutation, without obtaining statistical significance (newborn rate: 5T/non-5T: 7.1/28%, p 0.45). No differences were found when comparing presence of severe CF, common CFTR gene mutations and ICSI-related parameters. CONCLUSION: The analysis of the presence of 5T polymporphism in CBAVD patients may add information when predicting the outcome of assisted reproductive techniques.


Assuntos
Doenças Urogenitais Masculinas , Técnicas de Reprodução Assistida , Ducto Deferente/anormalidades , Estudos de Coortes , Regulador de Condutância Transmembrana em Fibrose Cística , Feminino , Humanos , Recém-Nascido , Masculino , Doenças Urogenitais Masculinas/genética , Gravidez
8.
Am J Law Med ; 45(2-3): 130-170, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31722626

RESUMO

In many areas of innovation, the United States is a leader, but this characterization does not apply to the United States' position in assisted reproductive technology innovation and clinical use. This article uses a political science concept, the idea of the "democratic deficit" to examine the lack of American public discourse on innovations in ART. In doing so, the article focuses on America's missing public consultation in health care innovation. This missing discourse is significant, as political and ethical considerations may impact regulatory decisions. Thus, to the extent that these considerations are influencing the decisions of federal agency employees, namely those who work within the U.S. Food and Drug Administration, the public is unable to participate in the decision-making process. This lack of a public discourse undermines the goals of the administrative state, which include democratic participation, transparency, and accountability. The United Kingdom, on the other hand, has had a markedly divergent experience with assisted reproductive technology innovation. Instead of ignoring the various ethical, social, and legal issues surrounding assisted reproductive technology innovation, the United Kingdom engaged in a five-strand public consultation on the topic of mitochondrial transfer, a form of assisted reproductive technology that uses genetic modification in order to prevent disease transmission. This article argues that after a multi-decade standstill in terms of the public discourse related to ethical issues associated with assisted reproductive technology and germline modification, it is time for the United States to institute a more democratic inquiry into the scientific, ethical, and social implications of new forms of assisted reproductive technology and ultimately, forthcoming medical innovations that involve genetic modification.


Assuntos
Democracia , Invenções/legislação & jurisprudência , Formulação de Políticas , Técnicas de Reprodução Assistida/legislação & jurisprudência , Participação da Comunidade , Governo Federal , Fertilização In Vitro/ética , Fertilização In Vitro/legislação & jurisprudência , Política de Saúde/legislação & jurisprudência , Humanos , Invenções/ética , Técnicas de Reprodução Assistida/ética , Responsabilidade Social , Participação dos Interessados , Governo Estadual , Inquéritos e Questionários , Reino Unido , Estados Unidos , United States Food and Drug Administration/legislação & jurisprudência
9.
Medicine (Baltimore) ; 98(47): e17966, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31764800

RESUMO

To investigate how uterine size and volume are associated with live birth rate in patients undergoing assisted reproduction technology.This prospective cohort study was conducted at the Reproductive Medicine Centre from January 2010 to May 2017. Multivariate binary logistic regression was used to evaluate the relations between uterine size, total volume, and live birth outcomes, after they were adjusted for the main influencing factors.A total of 7320 women of clinical pregnancy were enrolled. Compared with uterine lengths of 50 to 59 mm (referent), women with uterine lengths ≥60 mm had a lower live birth rate (RR = 1.541). Compared with uterine widths of ≥50 mm (referent), women with uterine widths <30 mm had a lower live birth rate (RR = 1.430). Compared with uterine anteroposterior diameters of <30 mm (referent), women with uterine anteroposterior diameters ≥50 mm had a lower live birth rate (RR = 1.636). Compared with uterine volumes of 30 to 49 mL (referent), women with volumes <30 mL and ≥70 mL had lower live birth rates (RR = 1.368 and 1.742, respectively).Our findings indicate that uterine sizes and volumes that were too large or too small reduced the live birth rate.


Assuntos
Coeficiente de Natalidade , Nascimento Vivo , Técnicas de Reprodução Assistida , Útero/anatomia & histologia , Adulto , Estudos de Coortes , Feminino , Humanos , Tamanho do Órgão , Gravidez , Estudos Prospectivos
10.
Soins Pediatr Pueric ; 40(311): 12-17, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757269

RESUMO

Medically assisted reproduction techniques are aimed at heterosexual couples, when both members are living, of reproductive age, consenting to acts of insemination or the transfer of embryos and presenting medically diagnosed infertility. The review of the law on bioethics could offer new perspectives for reproduction notably by allowing access to medically assisted reproduction (MAR) to all women, elective egg freezing, the lifting of gamete donor anonymity and the authorisation of post-mortem MAR.


Assuntos
Bioética , Infertilidade , Técnicas de Reprodução Assistida , Feminino , Humanos , Técnicas de Reprodução Assistida/ética
11.
Soins Pediatr Pueric ; 40(311): 18-20, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757270

RESUMO

Undertaking medically assisted reproduction (MAR) is a real ordeal for a couple. Beyond the technical aspect, the physician must also support this patients psychologically and acknowledge their distress. The doctor's first mission is to advise the couple who will remain the sole decision-maker with regard to the actions undertaken.


Assuntos
Técnicas de Reprodução Assistida , Humanos
12.
Soins Pediatr Pueric ; 40(311): 21-25, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757271

RESUMO

Determined in 1994, the legal framework for medically assisted reproduction has barely evolved since. French legislation is among the strictest in Europe. Sweeping changes are planned for the next review of the law on bioethics which should be put to a vote in 2020. The current ban on surrogacy should however remain in place.


Assuntos
Técnicas de Reprodução Assistida , Europa (Continente) , França , Humanos , Técnicas de Reprodução Assistida/legislação & jurisprudência
13.
Soins Pediatr Pueric ; 40(311): 35-36, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757274

RESUMO

Raphaël was conceived in 1976 by donor insemination. He describes his experience of the late discovery of his conception. Not being able to know his sperm donor and being denied access to his origins prevents him from being able to fully fathom the unknown part of him in order to shape his own person.


Assuntos
Técnicas de Reprodução Assistida , Doadores de Tecidos , Humanos , Masculino , Pais
14.
Soins Pediatr Pueric ; 40(311): 37-39, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757275

RESUMO

Following a diagnosis of infertility, Claire and Michael decided to explore the option of medically assisted reproduction. They share their journey, their experience and their suffering on this long and difficult pathway towards pregnancy.


Assuntos
Infertilidade , Técnicas de Reprodução Assistida , Feminino , Humanos , Gravidez
15.
Soins Pediatr Pueric ; 40(311): 40-43, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757276

RESUMO

In situations of medically assisted reproduction (MAR), some questions face the future parents which may impact on the construction of the bond with their child. These challenges mean that the support provided needs to go further than the simple technical response. Supporting those seeking reproduction assistance and those who have become parents with their child, as they are, where they are at with their desire for a child and their baby, constitutes the main challenge of clinical interviews in MAR.


Assuntos
Pais , Técnicas de Reprodução Assistida , Criança , Humanos , Lactente
16.
Soins Pediatr Pueric ; 40(311): 44-46, 2019 Nov.
Artigo em Francês | MEDLINE | ID: mdl-31757277

RESUMO

Many patients undergoing medically assisted reproduction turn to alternative medicines such as acupuncture, sophrology or osteopathy in order to help them fulfil their desire for a child. What do these techniques consist in? What are their physical and psychological benefits? This article provides some explanations.


Assuntos
Terapias Complementares , Técnicas de Reprodução Assistida , Criança , Humanos
17.
Vet Clin North Am Equine Pract ; 35(3): 607-642, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31672204

RESUMO

Donkeys are nonseasonal, polyestrous, territorial, and nonharem breeders. Although there are many similarities between horses and donkeys, there are also reproductive features that differ, from the longer cervix in the jenny to spermatogenic efficiency in the jack. Mules display reproductive cyclic activity but are rarely fertile. Frozen donkey semen has high pregnancy rates in mares, but lower rates in jennies. This article reviews key aspects of donkey and mule reproductive physiology, reproductive medicine, and assisted reproductive techniques that are useful for practitioners offering assisted reproductive techniques, and also for practitioners with the occasional client with a basic reproductive question.


Assuntos
Equidae/fisiologia , Reprodução/fisiologia , Técnicas de Reprodução Assistida/veterinária , Animais , Feminino , Cavalos , Masculino , Gravidez
18.
Clin Ter ; 170(5): e364-e367, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31612194

RESUMO

In the last 40 years, the number of elderly patients that require Assisted Reproductive Technologies (ART) has risen enormously, especially after heterolougus fertilization techniques have become available. In recent years, the incidence of peripartum cardiomyopathy (PPCM) has substantially grown, as a consequence of the combined effect of increased maternal age, consequent high prevalence of hypertension and metabolic syndrome (MS). That cohort of women may be exposed to a greater number of cardiac, obstetric and anesthesio-logical complications, therefore the incidence of medico-legal issues, litigation, liabilities and claims over the past years has significantly risen. Cardiovascular and hormonal changes during pregnancy can challenge even the healthiest of individuals, and in that pregnant population the risk is even greater. These patients should be monitored before the ART, during pregnancy, delivery and puerperium, to avoid heart failure, thrombotic problems, embolic complications, stroke and death. Management issues regarding pregnancy and delivery are elaborate, including anesthesia considerations. This new population of women needs an accurate cardiac risk stratification with a thorough cardiovascular history and examination, 12 lead ECG, and transthoracic echocardiogram. Therefore, a comprehensive multidisciplinary assessment and management can provide the best opportunity to improve maternal and neonatal outcomes.


Assuntos
Síndrome Metabólica/etiologia , Complicações Cardiovasculares na Gravidez/etiologia , Técnicas de Reprodução Assistida/legislação & jurisprudência , Adulto , Fatores Etários , Idoso , Feminino , Humanos , Síndrome Metabólica/prevenção & controle , Gravidez , Complicações Cardiovasculares na Gravidez/prevenção & controle , Gestantes , Técnicas de Reprodução Assistida/efeitos adversos , Fatores de Risco
19.
Medicine (Baltimore) ; 98(38): e17329, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31568019

RESUMO

Thus far, all clinical trials evaluating the efficacy of embryo transfer strategies have selectively delayed the first frozen embryo transfer (FET) by at least 1 menstrual cycle. Nevertheless, this approach, which is based solely on clinical experience, may create unnecessary psychological stress on infertile patients who are anxious to conceive as soon as possible. This study aimed to investigate whether the time interval between oocyte retrieval and subsequent FET affects reproductive outcomes.We implemented a large retrospective cohort study in a single assisted reproductive technology (ART) unit at a university-based hospital, including 1540 autologous FET cycles performed in freeze-all cycles. The beginning of the FET was classified as either 'cycle 1' (performing FET within the first menstrual cycle) or 'cycle ≥2' (performing FET after one or more menstrual cycles). Live birth rate (LBR) was the primary outcome of our study.The mean interval for 'cycle 1' and 'cycle ≥2' FETs was 25.72 ±â€Š5.10 days and 75.33 ±â€Š24.85 days, respectively (P < .001). The type of controlled ovarian hyperstimulation (COH) and endometrial preparation protocols differed significantly between groups (P = .008 and P = .004, respectively). However, FET groups were similar in many ways. Univariate analysis showed that there was no significant difference in LBR between the different cycles (33.1% after 'cycle 1' FET vs 34.2% after 'cycle ≥2' FET, P = .68). To evaluate whether LBR remained unchanged after adjustment for potential confounders, we performed multivariate logistic regression. FET timing had no significant impact on LBR in the first FET (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 0.80-1.39).In accordance with the present study, it might not be necessary for clinicians to wait more than 1 menstrual cycle before performing FET. This allows us to reduce otiose deferment in FET, without adversely affecting reproductive outcomes.


Assuntos
Fase de Clivagem do Zigoto , Criopreservação , Transferência Embrionária/métodos , Ciclo Menstrual , Adulto , Feminino , Humanos , Gravidez , Resultado da Gravidez , Técnicas de Reprodução Assistida , Estudos Retrospectivos
20.
Gynecol Oncol ; 155(3): 522-529, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31604663

RESUMO

An increasing number of women in modern societies are delaying childbearing beyond the age of 35, and gynecologic cancers affect a significant proportion of reproductive age women who wish to preserve fertility for a future chance of childbearing. As a result, providing treatment options for fertility preservation in women with gynecologic cancer has become a crucial component of cancer survivorship care. In this review article, we discussed the current knowledge on fertility-sparing surgical approaches, as well as assisted reproductive technologies that can be utilized to preserve reproductive potential in women with cervical, endometrial, and ovarian cancer. A brief section on fertility preservation in pediatric gynecologic malignancies is also provided.


Assuntos
Preservação da Fertilidade/métodos , Neoplasias dos Genitais Femininos/terapia , Feminino , Neoplasias dos Genitais Femininos/cirurgia , Humanos , Técnicas de Reprodução Assistida
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