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1.
Rev Chilena Infectol ; 36(4): 414-420, 2019 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-31859763

RESUMO

Taurolidine is a broad-spectrum antiseptic used as lock therapy solution in adult and pediatric patients with long term central venous catheters (CVC) for the prevention of catheter related bloodstream infections (CRBSI). Taurolidine doesn't induce the resistant development and has only minor and brief side effects, which makes it an alternative both as a lock therapy and for the prevention of CRBSI in this group of patients.


Assuntos
Anti-Infecciosos Locais/administração & dosagem , Infecções Relacionadas a Cateter/prevenção & controle , Cateteres Venosos Centrais/efeitos adversos , Taurina/análogos & derivados , Tiadiazinas/administração & dosagem , Humanos , Taurina/administração & dosagem
2.
Nutrients ; 11(9)2019 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-31540245

RESUMO

Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospective associations were assessed using Cox regression analyses. Graft failure was defined as the start of dialysis or re-transplantation. In RTR (58% male, 53 ± 13 years old, estimated glomerular filtration rate (eGFR) 45 ± 19 mL/min/1.73 m2), urinary taurine excretion (533 (210-946) µmol/24 h) was significantly associated with serum free sulfhydryl groups (ß = 0.126; P = 0.001). During median follow-up for 5.3 (4.5-6.0) years, 83 (12%) patients developed graft failure. In Cox regression analyses, urinary taurine excretion was inversely associated with graft failure (hazard ratio: 0.74 (0.67-0.82); P < 0.001). This association remained significant independent of potential confounders. High urinary taurine excretion is associated with low risk of late graft failure in RTR. Therefore, increasing taurine intake may potentially support graft survival in RTR. Further studies are warranted to determine the underlying mechanisms and the potential of taurine supplementation.


Assuntos
Rejeição de Enxerto/urina , Taurina/urina , Adulto , Idoso , Feminino , Sobrevivência de Enxerto/efeitos dos fármacos , Humanos , Transplante de Rim , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , Taurina/administração & dosagem , Transplantados
3.
Amino Acids ; 51(9): 1307-1321, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31428910

RESUMO

This study aimed to evaluate the effect of taurine (tau) supplementation to low fishmeal (FM) diets on growth performance, oxidative status, and immune response of European seabass juveniles. Four isoproteic (46% crude protein) and isolipidic (19% crude lipid) diets were formulated to contain either 25 or 12.5% FM and a mixture of plant feedstuffs, supplemented or not with 1% tau. Twelve groups of 20 fish (IBW = 9.4 g) were fed each diet for 9 weeks. Reduction of dietary FM from 25 to 12.5% impaired growth performance, feed efficiency, and protein efficiency ratio but had no effect on nitrogen retention (% N intake). Independently of FM level, dietary tau supplementation improved growth performance and nitrogen retention without affecting feed efficiency. Dietary FM level reduction increased liver G6PDH activity, but did not affect lipid peroxidation or activities of redox key enzymes. Contrarily, dietary tau supplementation decreased hepatic G6PDH and GPX activities and lipid peroxidation. Gene expression COX-2 was not affected either by FM or tau levels but TNF-α increased with the reduction of FM level but not with the tau level. Dietary tau supplementation decreased Casp3 and Casp9 expression regardless of dietary FM level. Overall, this study evidenced that dietary tau supplementation improved growth performance and antioxidant response and reduced intestine inflammatory and apoptosis processes.


Assuntos
Ração Animal , Bass/metabolismo , Fígado/enzimologia , Taurina/administração & dosagem , Animais , Antioxidantes/metabolismo , Apoptose , Bass/imunologia , Caspase 3/metabolismo , Caspase 9/metabolismo , Dieta/veterinária , Glucosefosfato Desidrogenase/metabolismo , Glutationa Peroxidase/metabolismo , Inflamação , Intestinos/imunologia , Intestinos/fisiologia , Peroxidação de Lipídeos/fisiologia , Fígado/metabolismo , Nitrogênio/metabolismo , Oxirredução , Prostaglandina-Endoperóxido Sintases/metabolismo , Fator de Necrose Tumoral alfa/metabolismo
4.
Adv Exp Med Biol ; 1155: 205-213, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468399

RESUMO

The purpose of this study was to investigate consumption patterns and perform Importance-Performance Analysis (IPA) of selective attributes of Home Meal Replacement (HMR) products according to taurine-related nutritional knowledge levels in Koreans aged 40-64 years as a basis for developing additional HMR products. The study included 793 adults (297 males and 496 females) who had experience in consuming HMR products and who lived in Seoul and its metropolitan areas, Korea. Data were collected using self-administered questionnaires. Statistical analysis was performed by using the SPSS 18.0 program. The subjects were classified into a high-level group (HG, 467 adults) and low-level group (LG, 326 adults) based on their taurine-related nutritional knowledge scores. Analysis of HMR consumption patterns showed that the frequency of HMR consumption in the HG was one to two times a month in 41.1% of the subjects and once every 3-4 months in 22.7% of the subjects, whereas, in the LG, it was one to two times a month in 39.3% of the subjects and four to six times a month in 24.5% of the subjects. With regarding to the reasons for purchasing HMR products, there was no significant difference between HG and LG (p = 0.089). The IPA analysis of HMR selective attributes included factor analysis of 14 selective attributes that were divided into three factors: 'convenience and taste', 'reliability and health', and 'brand and awareness'. The average importance scores of the first (p < 0.01), second (p < 0.001), and third (p < 0.01) factors in the HG were significantly higher than those in the LG. In addition, the average satisfaction with the first factor (p < 0.01) in the HG was significantly higher than that in the LG. Based on the IPA results, the selective attributes with low satisfaction and high importance were price, origin, food additives, and nutrient content in both the HG and LG. In the second IPA quadrant was safety, but only in the LG. Multiple regression analysis revealed that the importance of the reliability and health factor and the satisfaction with the convenience and taste factor were positively influenced by the subject's taurine-related nutritional knowledge score. These results suggest that reliability and safety of HMR products need to be improved to meet the expectations of Korean consumers aged 40 years and older with a high level of taurine-related nutritional knowledge. Therefore, there is a need to produce HMR products that use safe and reliable food ingredients.


Assuntos
Alimentos Fortificados , Conhecimentos, Atitudes e Prática em Saúde , Taurina/administração & dosagem , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , República da Coreia , Inquéritos e Questionários , Paladar
5.
Adv Exp Med Biol ; 1155: 215-222, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468400

RESUMO

It has been reported that taurine intake in the past may have a positive effect on present cognitive function in the elderly. The purpose of this cross-sectional study was to investigate the need to develop an elderly-friendly home meal replacement (EF-HMR) containing taurine for the prevention of dementia in Korean adults aged 40-84 years. Study subjects included 481 adults 40-49 years group, 319 adults 50-64 years group, and 181 elderly group (65-84 years old) residing in Seoul and its metropolitan area, Korea. Data were collected from adults aged 40-64 years by self-administered questionnaires and from elderly through face-to-face interviews. Statistical analysis was performed using SPSS 18.0. The level of need for EF-HMR was significantly higher in 40-49 years and 50-64 years groups compared to the elderly group (p < 0.001). With regard to the preferred EF-HMR taste, the needs for less salty (p < 0.01) and less sweet (p < 0.001) foods were significantly higher in 40-49 years group compared to the elderly group. The main factors of consideration in the development of EF-HMR were nutrition, taste, and freshness. The level of need for EF-HMR containing taurine was significantly lower in those 40-49 years and 50-64 years groups compared to the elderly group (p < 0.01). If an EF-HMR containing taurine for prevention of dementia was developed, willingness to buy such a food was significantly higher in the elderly group than in those 40-49 years and 50-64 years groups (p < 0.01). Regarding cooked EF-HMR containing taurine, semi-prepared and ready-made meals were preferred in 71.1% and 25.4% in 40-49 years group, 69.6% and 22.6% in 50-64 years group, and 47.0% and 33.7% in the elderly group, respectively (p < 0.001). EF-HMR containing taurine sales unit sizes containing 3 servings or 1 serving was preferred by 37.2% and 26.3% of all subjects. The preferred places to purchase EF-HMR (in descending order of super-supermarket (mart), supermarket, and convenience store) were the same among the age groups. Therefore, it is necessary to understand the diversity present in the needs and purchasing characteristics of adults involved purchasing EF-HMR containing taurine, and there is a need to develop age-specific customized products for the elderly and for Korean adults 40-64 years old.


Assuntos
Demência/prevenção & controle , Alimentos Fortificados , Taurina/administração & dosagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Humanos , Pessoa de Meia-Idade , Estado Nutricional , República da Coreia
6.
Adv Exp Med Biol ; 1155: 223-230, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468401

RESUMO

This study aimed to estimate the dietary taurine intake and its food sources in Korean's aged between 19 and 29 years. The study included 619 participants (292 males and 327 females) who had provided data via a 24-h recall method to the 2015 Korea National Health and Nutrition Examination Survey (KNHANES). Dietary taurine intake and the sources of dietary taurine were estimated by using CAN-Pro 4.0 software. Statistical analysis was performed by using SPSS 20.0. Average height and weight of the subjects was 174 cm and 73.5 kg in males and 161 cm and 56.4 kg in females, respectively. The prevalence of obesity in males was significantly higher compared to females (p < 0.001). Overall, the nutrient intakes of subjects were higher than the dietary reference intakes for Korean's (KDRIs). In particular, phosphorus and sodium intakes of males and females were higher, whereas, potassium and calcium intakes of males and females were lower than the KDRIs. The average intake of taurine 327.3 mg by males was significantly higher compared to 245.1 mg by females (p < 0.05). With regard to dietary taurine intake from the main food groups, meat (p < 0.001), vegetable (p < 0.001), beverages and alcohol (p < 0.05), and cereal (p < 0.001), in males was significantly higher compared to females. This study showed that 19-29 years old Korean young adults had a high intake of taurine due to high intake of protein. However, since high intake of meat can lead to chronic disease, it is necessary to provide nutrition education to increase the intake of fishes and shellfishes as a taurine source food.


Assuntos
Dieta , Inquéritos Nutricionais , Taurina/administração & dosagem , Adulto , Feminino , Alimentos , Humanos , Masculino , República da Coreia , Adulto Jovem
7.
Adv Exp Med Biol ; 1155: 231-238, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468402

RESUMO

The purpose of this research is to investigate the effects of dietary taurine supplementation on blood and urine taurine concentrations of the elderly women with dementia. Subjects were 31 female elderly with dementia hospitalized in a geriatric hospital. They were divided randomly into control group and dietary taurine supplemented group. Basically, same meals were served to both groups. Scorched rice water without taurine were served to control group. Scorched rice water containing 3 g of taurine were reserved to taurine group with lunch similarly. Food ingredients containing high concentration of taurine were eliminated from the meal menu. Blood and urine samples were obtained from each subject at the beginning of study, after 2 week and 4 weeks in the morning fasting state. Taurine concentrations in serum and urine were measured as taurine-fluorescamine derivatives using high performance liquid chromatography (HPLC). Data were analyzed using SPSS 20.0. The average taurine concentrations in serum and urine of subjects were 89.2 ± 9.5 µM and 876.7 ± 97.1 µM at the beginning. After 4 weeks, the taurine concentrations in serum and urine of dietary taurine supplemented group were 218.0 ± 15.6 µM and 6502.6 ± 380.6 µM, which were significantly higher compared to control group. Dietary taurine supplemented group showed positive changes in the score on language and execute performance. So taurine supplementation can provide beneficial effects to the elderly and the elderly with dementia.


Assuntos
Demência/sangue , Demência/urina , Suplementos Nutricionais , Taurina/administração & dosagem , Idoso , Feminino , Humanos , Taurina/sangue , Taurina/urina
8.
Adv Exp Med Biol ; 1155: 249-259, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468404

RESUMO

The purpose of this study was to investigate food preference of the elderly for the development of taurine-containing elderly-friendly foods (TEF). The subjects in this study were 278 elderly people who were over 65 years old. All data were collected by face to face interview. Statistical analysis was performed by using SPSS 20.0 for Windows. The 'low-salt diet', 'nutritional enriched diet', and 'swallow able diet' were diets that all subjects preferred. All subjects preferred a diet to be sold as three items in separate packaging, as a semi-cooked type. The food types and cooking methods that showed high preference and had a high intention to purchase were cooked rice, porridges, soups and stews, meat side dishes, fish side dishes, kimchi, and vegetable dishes and steaming Among the taurine-containing foods, whip-arm octopus, manila clam, dried anchovy, flatfish, pollack, laver, green laver, sea tangle, seaweed, cod, croaker, and cutlassfish were the preferred foods of most subjects. Elderly females preferred significantly more squid, octopus, eel, mudfish, and sea cucumber than that of elderly males (p < 0.05). Elderly males preferred and consumed significantly more taurine-supplement than did elderly females (p < 0.05). These results will be used as baseline data for development of a customized TEF for Korean elderly.


Assuntos
Dieta , Preferências Alimentares , Taurina/administração & dosagem , Idoso , Culinária , Feminino , Humanos , Masculino , República da Coreia , Alimentos Marinhos , Verduras
9.
Adv Exp Med Biol ; 1155: 273-282, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468406

RESUMO

Taurine has been reported to play a key role in the growth and development of children's brains and nerves. Incorrect dietary habits and unbalanced nutrient intakes may be caused by socio-environmental and economic factors in low-income children. This study was conducted to investigate changes in blood lipid profiles, nutrition knowledge, dietary attitudes, and intakes of dietary taurine and nutrients after an 8-week nutrition education program (NEP) in low-income Korean children. In this intervention study, nutrition education, exercise, and nutrition counseling were conducted for 8-weeks in 22 low-income children (11-13 years old, 9 males and 13 females) at community child center located in Incheon, Korea. Changes after the NEP were evaluated using a one group pretest-posttest design. Statistical analysis was performed using SPSS 20.0. After the 8-week NEP, there was a significant decrease in the blood triglyceride level of female students (p < 0.01). As for nutrition knowledge, there were significant increases in the subscore of sugars and sodium in foods consumed by male students (p < 0.05), total score of nutrition knowledge (p < 0.01), subscore of sugars and sodium in foods (p < 0.01), and fat content of foods and adequate dietary intake in female students (p < 0.05). Dietary attitudes did not change. There were significant increases in intakes of dietary taurine, vitamin B6 (p < 0.01), and dietary fiber (p < 0.05) in female students after the NEP. There were significantly positive correlations between changes in dietary taurine intake and dietary attitudes as well as between changes in carbohydrate intake and total cholesterol level among all the subjects. Therefore, nutrition education to promote balanced nutrient intake and dietary attitudes for optimal growth and development of low-income children is needed.


Assuntos
Dieta , Conhecimentos, Atitudes e Prática em Saúde , Lipídeos/sangue , Ciências da Nutrição/educação , Estado Nutricional , Taurina/administração & dosagem , Adolescente , Criança , Ingestão de Energia , Feminino , Humanos , Masculino , Pobreza , República da Coreia
10.
Adv Exp Med Biol ; 1155: 283-292, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468407

RESUMO

Taurine is a free amino acid and exhibits various biological functions such as brain development, retinal photoreceptor activity, reproduction, normal growth development and antioxidant activity. Taurine is mainly contained in meat and fish foods. Although taurine is inferred to be implicated in the development of the fetus, there are few reports of taurine intake and neonatal growth in pregnant women. Therefore, the purpose of this study was to evaluate the nutrient and taurine intake of pregnant women during the late gestation period using the food intake frequency method. The study was approved by the Institutional Review Board of the Keimyung University. The daily taurine intake of the pregnant women was 104.2 mg. The daily taurine intakes of the pregnant women were divided into three groups for analysis; low, middle, high (<60 mg, 60-120 mg, and >120 mg). The body weight of the top taurine group (3.37 kg) was significantly higher than that of the low and middle groups (3.16 kg, 3.20 kg). Also, the heights of the infants were 49.9 cm, 49.8 cm, and 51.1 cm for each group, showing significantly high measure in the group of taurine intake more than 120 mg/day. There was a positive correlation between the taurine intake of the pregnant women and the height of the newborns. In conclusion, weight and height at birth were significantly higher in the high taurine intake group of the pregnant women. There was a positive correlation between maternal taurine intake and birth length.


Assuntos
Dieta , Fenômenos Fisiológicos da Nutrição Materna , Taurina/administração & dosagem , Animais , Estatura , Peso Corporal , Feminino , Peixes , Humanos , Recém-Nascido , Carne , Gravidez
11.
Adv Exp Med Biol ; 1155: 293-300, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468408

RESUMO

This study was conducted to investigate the correlation between dietary taurine intake, nutrients intake, dietary attitudes, dietary behaviors, and life stress by depression in Korean female college students. Depression was measured by self-reported symptoms of depression on the CES-D (Center for Epidemiologic Studies Depression) scale. The subjects of this cross-sectional study included 56 female college students with depression (depression group, DG) and 122 female students without depression (control group, CG). Self-reported life stress score was determined using the life stress scale developed for Korean college students. Intakes of dietary taurine and nutrients were assessed using 3-day food records (2 weekdays and 1 weekend day) and evaluated using the computer aided nutrition program 4.0 version. Statistical analysis was performed using SPSS 24.0. We observed no significant difference in the average dietary taurine intake between DG (87.6 mg/day) and CG (92.3 mg/day). The average dietary intakes of vitamin A and calcium in DG were significantly lower as compared to CG (p < 0.05). The average total scores of dietary attitudes (p < 0.01) and dietary behaviors (p < 0.05) in DG were significantly lower as compared to CG. The average total life stress score (p < 0.001) and all stress categories were significantly higher in DG as compared to CG. No significant correlation was observed between the CES-D scale score and dietary taurine intake. However, there were significant negative correlations between the CES-D scale score and vitamin A, folic acid, vitamin C, and calcium intakes (p < 0.05), dietary attitudes, and dietary behaviors (p < 0.01). Scores of the CES-D scale and life stress showed a significantly positive correlation (p < 0.01). Therefore, continuous nutrition education and counseling for good dietary attitudes and behaviors are required. Future studies need to be undertaken to confirm the correlation between dietary taurine intake and depression by intervention with taurine.


Assuntos
Depressão/epidemiologia , Dieta , Estresse Psicológico , Taurina/administração & dosagem , Atitude , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , República da Coreia , Estudantes
12.
Adv Exp Med Biol ; 1155: 301-311, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468409

RESUMO

Taurine can suppress the creation of lipid hydroperoxide and decrease the level of total cholesterol and triglyceride in the blood. This study aimed to analyze the relationship between biochemical indicators associated with cardiometabolic disease and taurine intake in elderly people. Subjects of this study were those participated in the Korea National Health and Nutrition Examination Survey (KNHANES) 2016, aged over 75 years old. Data of dietary intake were collected through 24-h dietary recall method, and for nutrient analysis, the taurine intake was divided into quadrants. Mean values of taurine intake were 237.8 ± 17.5 mg/day in men and 157.5 ± 12.4 mg/day in women. Both men and women in the quadrants with the higher level of taurine intake appeared to show high intake levels of energy, protein, fat, total cholesterol, calcium, phosphorus, sodium, potassium, riboflavin, and niacin. As a result of relationship analysis between taurine intake and cardiometabolic risk markers (total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, blood pressure, blood glucose, and atherogenic index), taurine intake showed a significantly negative relation with AI in men but showed a positive relation in women with DBP.


Assuntos
Doenças Cardiovasculares/epidemiologia , Dieta , Inquéritos Nutricionais , Taurina/administração & dosagem , Idoso , Feminino , Humanos , Masculino , República da Coreia/epidemiologia , Fatores de Risco
13.
Adv Exp Med Biol ; 1155: 313-321, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468410

RESUMO

This study surveyed that the relationship between the frequencies of intake of taurine-contained nutritional drinks (TCND), and lifestyle and the purposes of intake it. The study was conducted a cross-sectional survey using 265 people (203 male, 62 female) aged 18-64 worked in two companies in Mie Prefecture, Japan between December 2017 and February 2018. The questionnaires gathered characteristics, demographic, socioeconomic, lifestyle habits and purpose of TCND intake. We divided the frequency of intake of TCND of at least a few times every month as the high-frequency TCND (HF-TCND) group, and the remaining as the low-frequency TCND (LF-TCND) group. Multivariate logistic regression analysis was used to investigate the relationship between characteristics, demographic, socioeconomic, lifestyle habits and purpose of TCND intake and HF-TCND after controlling for individual variables. Of all participants, 13.4% was evaluated as HT-CND. 16.3% for male or 4.3% for female were evaluated as HF-TCND (p < 0.05). The most reason for frequent choosing a TCND was fatigue recovery. Logistic regression analysis showed that sex, occupation, purpose of TCND intake and stressful are related to HF-TCND. Our study indicates that purpose of TCND intake, such as fatigue recovery and reducing stress, may partly affect the frequency of intake of TCND. Therefore, we must continue to show scientific evidence for taurine by enlightenment activity etc.


Assuntos
Alimentos Fortificados , Estilo de Vida , Taurina/administração & dosagem , Adolescente , Adulto , Bebidas , Estudos Transversais , Comportamento Alimentar , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Adulto Jovem
14.
Adv Exp Med Biol ; 1155: 323-333, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468411

RESUMO

The purpose of this study was to investigate the correlations among taurine-related nutritional knowledge (TNK), taurine intake frequency (TIF), and cognitive function (CF) in Korean elderly. Subjects of this cross-sectional study were 278 elderly persons in Korea without dementia (men 76, women 202). The subjects were divided into two groups: a group with a lower than average TNK score (LAG) and a group with a higher than average TNK score (HAG). Data were obtained via questionnaires and 1: 1 interviews. Correlation analysis available in SPSS 20.0 was used to analyze associations among the three factors. Average TNK score of all subjects was 4 out of 10 points, while that of the LAG (1.9 points) was significantly lower than that of the HAG (6.6 points) (p < 0.001). Average TIF score in the HAG (195.3 points) was significantly higher than that of the LAG (180.8 points) (p < 0.001). Compared to the LAG, the HAG members more frequently consumed foods such as webfoot octopus, whelk, dried anchovy, dried shrimp, mackerel, anglerfish, skate, short-necked clam, shrimp, and dried squid (p < 0.01). There was no significant difference in CF scores between the LAG and HAG. There was positive correlation between TNK and TIF scores in all the subjects (p < 0.01). There was no significant difference, but there was a tendency for a positive correlation, between TNK and CF scores (p = 0.072). These results suggest that nutritional education of the elderly about taurine is needed, and it is strongly recommended that the elderly frequently consume taurine-containing foods and supplements to prevent dementia.


Assuntos
Cognição , Dieta , Conhecimentos, Atitudes e Prática em Saúde , Taurina/administração & dosagem , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , República da Coreia , Alimentos Marinhos
15.
Adv Exp Med Biol ; 1155: 335-347, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468412

RESUMO

This study was conducted to investigate the effects on the cognitive function of the elderly with dementia, after consumption of menus developed to prevent dementia. For the purpose of this study, we developed two menus incorporating lotus seeds and taurine which are known to be effective in preventing dementia: tea supplemented with taurine and lotus seed (TATL) and scorched glutinous rice water supplemented with taurine and lotus seed (SATL). The most optimized supplement was determined through sensory evaluation, and was served with the normal diet for 4 weeks. The subjects of this study were 46 elderly women with dementia, divided into three groups: 16 subjects in the taurine supplement group (TG), 15 subjects in the taurine and lotus seeds supplement group (TLG), and 15 subjects in the control group (CG). Cognitive function was assessed by comparing the scores of MMSE-DS (Mini-Mental State Examination-Dementia Screening) before and after dietary supplementation, with higher scores indicating better cognitive functions. Statistical analysis was performed using SPSS 20.0 for Windows. The total score of MMSE-DS before supplementation SATL was not significantly different between CG (14.1 points), TG (14.2 points), and TLG (13.8 points). However, after consuming the SATL supplement, the total score of TG (16.7 points) and TLG (16.9 points) significantly increased (p < 0.01). In particular, in the case of TG, a significant increase was observed in the score for 'Judgment and abstract thinking' (p < 0.05). An increased tendency was also observed for scores of 'Place orientation' (p = 0.071) and 'Ability to execute' (p = 0.054), although statistically not significant. In the case of TLG, score of 'Place orientation' and 'Judgment and abstract thinking' was significantly increased (p < 0.05). These results show that dietary taurine supplementation has positive effects on the cognitive function (MMSE-DS) of elderly women with dementia. There-fore, it is necessary to include dietary taurine supplementation for the treatment and prevention of dementia. In addition, it is necessary to develop and supply a variety of menus containing taurine.


Assuntos
Cognição , Demência/prevenção & controle , Suplementos Nutricionais , Taurina/administração & dosagem , Idoso , Feminino , Humanos
16.
Adv Exp Med Biol ; 1155: 349-358, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31468413

RESUMO

Taurine is a ß-amino acid found most broadly distributed in human body, abundant in animal foods, and has an antioxidative function. Current nutritional intake and dietary habits of children in elementary schools show low level of the intake of vegetable foods and high level of the intake of processed foods and fast foods; this necessitates the emphasis of the intake of antioxidative nutrients for children. On account of the less consumption of vegetable foods as a main source of antioxidative nutrients for elementary school children, animal foods containing abundant amount of taurine can be preferably taken as an alternative foods therefor. Many previous studies have reported the protein intake of the children in elementary schools so far. However, the studies, reported the intake of taurine of elementary school children, are few. Thus, this study analyzed taurine and nutrients intake for children in Daegu, Korea. The average daily energy intake of the children was 153 ± 155 mg/day. The mean taurine intake values are followed; 27.6 ± 11.6 mg/day in the Q1 group, 61.2 ± 10.0 mg/day in the Q2 group, 137.7 ± 51.1 mg/day in the Q3 group, and 385.9 ± 123.6 mg/day in the Q4 group (p < .001). Q3 and Q4 groups showed significantly higher level of the intake of vitamin D, vitamin B12, Calcium, and folate than those of Q1 and Q2 groups. In the study, foods that affected the intake of taurine were as followed; fish and shellfish (79%), meat (14%), seaweed (5%), and other food products (2%).As a consequence, Taurine intake appears to be affected by seafood intake, and if seafood is consumed primarily, the amount of energy intake would be appropriate and will contribute to the increase of intakes of taurine, calcium and vitamin D.


Assuntos
Dieta , Ingestão de Energia , Taurina/administração & dosagem , Cálcio/administração & dosagem , Criança , Humanos , Nutrientes/administração & dosagem , República da Coreia , Alimentos Marinhos , Vitamina D/administração & dosagem
17.
Physiol Res ; 68(3): 519-523, 2019 06 30.
Artigo em Inglês | MEDLINE | ID: mdl-31301731

RESUMO

Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group - mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group - mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine - treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.


Assuntos
Densidade Óssea/efeitos dos fármacos , Fêmur/efeitos dos fármacos , Fêmur/patologia , Taurina/administração & dosagem , Animais , Densidade Óssea/fisiologia , Osso Cortical/citologia , Osso Cortical/efeitos dos fármacos , Osso Cortical/fisiologia , Esquema de Medicação , Fêmur/fisiologia , Camundongos , Distribuição Aleatória , Taurina/toxicidade
18.
PLoS One ; 14(6): e0214347, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31211780

RESUMO

Dietary insufficiencies have been well documented to decrease growth rates and survival (and therefore overall production) in fish aquaculture. By contrast, the effects of dietary insufficiencies on the sensory biology of cultured fish remains largely unstudied. Diets based solely on plant protein sources could have advantages over fish-based diets because of the cost and ecological effects of the latter, but plant proteins lack the amino acid taurine. Adequate levels of taurine are, however, necessary for the development of a fully functional visual system in mammals. As part of ongoing studies to determine the suitability of plant-based diets, we investigated the effects of normal and reduced taurine dietary levels on retinal anatomy and function in European sea bass (Dicentrarchus labrax). We could not demonstrate any effects of dietary taurine level on retinal anatomy, nor the functional properties of luminous sensitivity and temporal resolution (measured as flicker fusion frequency). We did, however, find an effect on spectral sensitivity. The peak of spectral sensitivity of individuals fed a 5% taurine diet was rightward shifted (i.e., towards longer wavelengths) relative to that of fish fed a 0% or 1.5% taurine diet. This difference in in spectral sensitivity was due to a relatively lower level of middle wavelength pigment (maximum absorbance .500 nm) in fish fed a 5% taurine diet. Changes in spectral sensitivity resulting from diets containing different taurine levels are unlikely to be detrimental to fish destined for market, but could be in fishes that are being reared for stock enhancement programs.


Assuntos
Bass/fisiologia , Taurina/administração & dosagem , Visão Ocular/efeitos dos fármacos , Ração Animal , Animais , Peso Corporal/efeitos dos fármacos , Pesqueiros , Retina/anatomia & histologia , Retina/efeitos dos fármacos , Retina/fisiologia , Taurina/farmacologia
19.
Trials ; 20(1): 315, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31151464

RESUMO

BACKGROUND: Taurine (Tau) is involved in many biochemical functions such as regulation of glucose and lipid metabolism, enhancement of energy expenditure, anti-inflammatory effects and appetite control. The most important effect of Tau in obesity is its direct effect on adipose tissue. Some evidence has shown an impaired FGF (fibroblast growth factor) 19 and 21 biosyntheses in obesity. Besides the effects of eicosapentaenoic acid on serum FGF concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising around the world and on the other side, Tau biosynthesis is reduced by adipose-tissue-derived factors in obesity, the effects of Tau and a weight-loss diet on obesity need to be investigated further. METHODS: We will conduct an 8-week. double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on fasting serum levels of FGFs, ß-Klotho co-receptor, some biochemical indices and body composition in 50 obese women aged between 18 and 49 years on a weight-loss diet. DISCUSSION: We will determine the other advantages of a weight-loss diet on new metabolic risk factors. Since Tau may regulate adipose-tissue-derived factors and a weight-loss diet can promote the useful effects of Tau supplementation; for the first time, the effects of a weight-loss diet along with Tau supplementation on these variables will be assessed. TRIAL REGISTRATION: Iran Clinical Trials Registry, ID: IRCT20131125015542N2 . Registered on 24 November 2018.


Assuntos
Composição Corporal , Dieta Redutora , Fatores de Crescimento de Fibroblastos/sangue , Proteínas de Membrana/sangue , Obesidade/dietoterapia , Ensaios Clínicos Controlados Aleatórios como Assunto , Taurina/administração & dosagem , Adolescente , Adulto , Interpretação Estatística de Dados , Suplementos Nutricionais , Método Duplo-Cego , Jejum , Feminino , Humanos , Pessoa de Meia-Idade , Obesidade/metabolismo , Adulto Jovem
20.
World J Surg Oncol ; 17(1): 93, 2019 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-31159819

RESUMO

BACKGROUND: Besides its known antibacterial effect commonly used in intraperitoneal lavage, taurolidine has been observed to possess antineoplastic properties. In order to analyse this antineoplastic potential in a palliative therapeutic setting, taurolidine (TN) was compared to mitomycin C (MMC) and oxaliplatin (OX), known antineoplastic agents which are routinely used in intraperitoneal applications, following pressurized intra-peritoneal aerosol chemotherapy (PIPAC). METHODS: An in vitro model was established using a colon adenocarcinoma cell line (HT-29 human cells). Different experimental dosages of TN and combinations of TN, MMC, and OX were applied via PIPAC. To measure cell proliferation, a colorimetric tetrazolium reduction assay was utilized 24 h after PIPAC. RESULTS: We demonstrated a cytotoxic effect of TN and OX (184 mg/150 mL, p < 0.01) on tumor cell growth. An increasing dosage of TN (from 0.5 g/100 mL to 0.75 g/150 mL) correlated with higher cell toxicity when compared to untreated cells (p < 0.05 and p < 0.01, respectively). PIPAC with OX and both OX and TN (0.5 g/100 mL) showed the same cytotoxic effect (p < 0.01). No significant impact was observed for MMC (14 mg/50 mL, p > 0.05) or MMC with OX (p > 0.05) applied via PIPAC. CONCLUSIONS: The intraperitoneal application of TN is mostly limited to lavage procedures in cases of peritonitis. Our results indicate a substantial antineoplastic in vitro effect on colon carcinoma cells following PIPAC application. While this effect could be used in the palliative treatment of peritoneal metastases, further clinical studies are required to investigate the feasibility of TN application in such cases.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Apoptose/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Neoplasias do Colo/patologia , Neoplasias Peritoneais/patologia , Aerossóis , Neoplasias do Colo/tratamento farmacológico , Humanos , Técnicas In Vitro , Mitomicina/administração & dosagem , Oxaliplatina/administração & dosagem , Neoplasias Peritoneais/tratamento farmacológico , Pressão , Taurina/administração & dosagem , Taurina/análogos & derivados , Tiadiazinas/administração & dosagem , Células Tumorais Cultivadas
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