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1.
Molecules ; 26(4)2021 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-33670668

RESUMO

Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.


Assuntos
Tecnologia Biomédica/tendências , Nanoestruturas/química , Sistemas de Liberação de Medicamentos , Difusão Dinâmica da Luz , Humanos , Nanoestruturas/ultraestrutura , Medicina Regenerativa , Eletricidade Estática
2.
Am J Ther ; 28(2): e217-e223, 2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33590991

RESUMO

BACKGROUND: The current coronavirus disease 2019 (COVID-19) pandemic has caused a significant strain on medical resources throughout the world. A major shift to telemedicine and mobile health technologies has now taken on an immediate urgency. Newly developed devices designed for home use have facilitated remote monitoring of various physiologic parameters relevant to pulmonary diseases. These devices have also enabled home-based pulmonary rehabilitation programs. In addition, telemedicine and home care services have been leveraged to rapidly develop acute care hospital-at-home programs for the treatment of mild-to-moderate COVID-19 illness. AREAS OF UNCERTAINTY: The benefit of remote monitoring technologies on patient outcomes has not been established in robust trials. Furthermore, the use of these devices, which can increase the burden of care, has not been integrated into current clinical workflows and electronic medical records. Finally, reimbursement for these telemedicine and remote monitoring services is variable. DATA SOURCES: Literature review. THERAPEUTIC ADVANCES: Advances in digital technology have improved remote monitoring of physiologic parameters relevant to pulmonary medicine. In addition, telemedicine services for the provision of pulmonary rehabilitation and novel hospital-at-home programs have been developed. These new home-based programs have been adapted for COVID-19 and may also be relevant for the management of acute and chronic pulmonary diseases after the pandemic. CONCLUSION: Digital remote monitoring of physiologic parameters relevant to pulmonary medicine and novel hospital-at-home programs are feasible and may improve care for patients with acute and chronic respiratory-related disorders.


Assuntos
Pneumopatias , Telemedicina , Tecnologia Biomédica/tendências , /terapia , Humanos , Pneumopatias/diagnóstico , Pneumopatias/reabilitação , Pneumopatias/terapia , Pneumologia/tendências , Telemedicina/métodos , Telemedicina/organização & administração
3.
PLoS Negl Trop Dis ; 14(9): e0007956, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32881862

RESUMO

In 2018, the government of the Republic of Korea (ROK), South Korean life science companies, and a group of international funders led by the Bill & Melinda Gates Foundation launched a new and innovative funding agency to support neglected-disease research and development (R&D). The new venture is known as the Research Investment for Global Health Technology (RIGHT) Fund.


Assuntos
Tecnologia Biomédica/economia , Doenças Negligenciadas/prevenção & controle , Tecnologia Biomédica/organização & administração , Tecnologia Biomédica/tendências , Administração Financeira , Saúde Global/economia , Humanos , Doenças Negligenciadas/economia , Doenças Negligenciadas/epidemiologia , República da Coreia/epidemiologia
5.
Policy Polit Nurs Pract ; 21(4): 195-201, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32746711

RESUMO

The 21st Century Cures Act, passed in December 2016 by the United States Congress, is a public law aimed at accelerating the time it takes to get pharmaceutical drugs and medical devices into the market, in addition to shifting connected review processes from randomized controlled trials to real-world efficacy tests. As of December 2019, efforts are underway to introduce a "Cures Act 2.0" bill, with particular attention to the implementation of digital health within health systems. Research on the development of emergent health technologies is nascent; research examining health technology implications of 21st Century Cures Act for the health care workforce is nonexistent. This article fills a crucial gap in public awareness, discussing ethical implications of the 21st Century Cures Act and centering nursing. Nursing is a profession frequently acknowledged as practicing on "the front lines of care" and frequently responsible for the trialing of products in clinical settings. The article summarizes and evaluates key components of the 21st Century Cures Act related to health technology development. Discrete health technologies addressed are (a) breakthrough devices, (b) digital health software, and (c) combination products. It then connects these provisions to ethical considerations for nursing practice, research, and policy. The article concludes by discussing the relevance of emerging digital health technologies to the crafting of a "Cures 2.0" bill, with particular attention to this moment in light of digital care precedents set during the COVID-19 pandemic.


Assuntos
Tecnologia Biomédica/ética , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Tecnologia de Sensoriamento Remoto/ética , Betacoronavirus , Tecnologia Biomédica/tendências , Infecções por Coronavirus/terapia , Cuidados Críticos/ética , Previsões , Humanos , Pandemias , Pneumonia Viral/terapia , Tecnologia de Sensoriamento Remoto/tendências , Estados Unidos
7.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(6): 809-812, 2020 Jun 10.
Artigo em Chinês | MEDLINE | ID: mdl-32564540

RESUMO

Cervical cancer is the fourth common cancer in women globally, with the number of new cases accounted for 18.6% among all the cancer patients, in China. It is well known that the situation of prevention and control programs are quite challenging. Based on the efforts being made in the last 20 years, the etiology and carcinogenesis on cervical cancer had been clearly understood. Breakthroughs had been achieved in the development of prophylactic human papillomovirus vaccine and the technology of in screening. Various screening strategies are already available in areas with different economic status. Nevertheless, the capacity of health care services at the primary care clinics needs to be improved to narrow the gap between the reality and the demands.


Assuntos
Tecnologia Biomédica/tendências , Neoplasias do Colo do Útero/prevenção & controle , China/epidemiologia , Detecção Precoce de Câncer/métodos , Feminino , Humanos , Vacinas contra Papillomavirus , Neoplasias do Colo do Útero/epidemiologia
9.
Telemed J E Health ; 26(10): 1226-1233, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32456560

RESUMO

Background: Coronavirus disease 2019 (COVID-19) has led to a national health care emergency in the United States and exposed resource shortages, particularly of health care providers trained to provide critical or intensive care. This article describes how digital health technologies are being or could be used for COVID-19 mitigation. It then proposes the National Emergency Tele-Critical Care Network (NETCCN), which would combine digital health technologies to address this and future crises. Methods: Subject matter experts from the Society of Critical Care Medicine and the Telemedicine and Advanced Technology Research Center examined the peer-reviewed literature and science/technology news to see what digital health technologies have already been or could be implemented to (1) support patients while limiting COVID-19 transmission, (2) increase health care providers' capability and capacity, and (3) predict/prevent future outbreaks. Results: Major technologies identified included telemedicine and mobile care (for COVID-19 as well as routine care), tiered telementoring, telecritical care, robotics, and artificial intelligence for monitoring. Several of these could be assimilated to form an interoperable scalable NETCCN. NETCCN would assist health care providers, wherever they are located, by obtaining real-time patient and supplies data and disseminating critical care expertise. NETCCN capabilities should be maintained between disasters and regularly tested to ensure continual readiness. Conclusions: COVID-19 has demonstrated the impact of a large-scale health emergency on the existing infrastructures. Short term, an approach to meeting this challenge is to adopt existing digital health technologies. Long term, developing a NETCCN may ensure that the necessary ecosystem is available to respond to future emergencies.


Assuntos
Tecnologia Biomédica/tendências , Defesa Civil/métodos , Infecções por Coronavirus/prevenção & controle , Cuidados Críticos/organização & administração , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Telemedicina/instrumentação , Infecções por Coronavirus/epidemiologia , Emergências , Feminino , Previsões , Saúde Global , Humanos , Masculino , Pandemias/estatística & dados numéricos , Pneumonia Viral/epidemiologia , Telemedicina/métodos , Estados Unidos
10.
Arch Phys Med Rehabil ; 101(8): 1313-1321, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32417442

RESUMO

OBJECTIVE: To summarize the progress toward the National Institutes of Health (NIH) Research Plan on Rehabilitation goals and the methods by which tracking occurred. DESIGN: Each grant award was manually coded by NIH staff for research plan goals, type of science categories (eg, basic, applied, infrastructure, etc), and if applicable, training, and then validated by NIH institute and center (IC) experts. Data for years 2015 through 2017 were used to develop a coding algorithm to automatically code grants in 2018 for validation by NIH IC experts. Additional data for all years (2015-2018) were also analyzed to track changes and progress. SETTING: The research utilized administrative data from NIH Reporter and internal NIH databases. PARTICIPANTS: The data sample included research grants and programs funded from fiscal years 2015 through 2018. The year 2015 was considered a baseline year as the research plan was published in 2016. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The primary outcome measures were substantial growth in NIH funding and numbers of awards for rehabilitation research, across most research plan goals and types of science, as well as validation of an automatic algorithm for coding grants. RESULTS: Number of grants, funding dollars, funding mechanisms, patent data, scientific influence and translational science, research plan goals, and type of science categories were tracked across years (2015-2018). Algorithm validation is presented for 2018 data. CONCLUSIONS: NIH advanced the goals stated in the Research Plan on Rehabilitation, but gap areas remain. Though funding in this portfolio is growing, continued focus and participation by the field is needed to advance rehabilitation science.


Assuntos
Algoritmos , Pesquisa Biomédica/tendências , Organização do Financiamento/tendências , National Institutes of Health (U.S.)/tendências , Reabilitação/tendências , Indexação e Redação de Resumos , Tecnologia Biomédica/tendências , Objetivos , Programas Governamentais/tendências , Humanos , Publicações/tendências , Reabilitação/instrumentação , Reabilitação/métodos , Projetos de Pesquisa/tendências , Pesquisa Médica Translacional/tendências , Estados Unidos
14.
Adv Exp Med Biol ; 1194: 151-156, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32468531

RESUMO

e-Health is referred to in literature as the usage of Information and Communication Technology (ICT) in the health domain, for administering treatment of patients, research, and health education and monitoring of public health in situ or remotely. Information and Communication Technology (ICT) plays a significant role in society today. Digitalization is changing all areas of human behavior, from social settings to basic needs, like health-related matters. The impact of new technology on improving health and well-being of individuals and populations is unprecedented, creating a phenomenon referred to as digital revolution in healthcare. The purpose of this paper is therefore to present DoctorCloud.net Platform for remote emergency, tactical health, and security support. It is a complete system for direct human support that offers immediate access to medical parameters and data via the Internet cloud.


Assuntos
Tecnologia Biomédica , Comunicação , Assistência à Saúde , Internet , Consulta Remota , Tecnologia Biomédica/tendências , Assistência à Saúde/métodos , Educação em Saúde , Humanos , Consulta Remota/métodos
15.
Artigo em Inglês | MEDLINE | ID: mdl-32471100

RESUMO

Medical innovation has a profound impact on public health, and it is always of social concern to encourage innovation and enhance the value in health care delivery. Based on a sample of China's listed firms in the medical industry from 2007 to 2018, this paper highlights the independent and mixed roles of informatization and high-speed rail in public medical innovation. The results show that informatization at network space and high-speed rail at physical space effectively promote the innovation of medical enterprises. In addition, "online" information technology and "offline" high-speed rail technology have a synergistic effect on medical innovation, especially in areas with a low level of innovation. The conclusion supports the positive significance of technology in the application of public health and proposes that the construction of smart society is very important to public health.


Assuntos
Tecnologia Biomédica/tendências , Setor de Assistência à Saúde , Invenções , Ferrovias/classificação , China , Saúde Pública , Tecnologia
16.
Artigo em Inglês | MEDLINE | ID: mdl-32340107

RESUMO

Digital health is uniquely positioned to enhance the way we detect and manage infectious diseases. This commentary explores the potential of implementing digital technologies that can be used at different stages of the COVID-19 outbreak, including data-driven disease surveillance, screening, triage, diagnosis, and monitoring. Methods that could potentially reduce the exposure of healthcare providers to the virus are also discussed.


Assuntos
Tecnologia Biomédica , Infecções por Coronavirus , Programas de Rastreamento , Monitorização Fisiológica , Pandemias , Pneumonia Viral , Vigilância da População , Telemedicina , Betacoronavirus , Tecnologia Biomédica/tendências , Busca de Comunicante , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Surtos de Doenças/prevenção & controle , Pessoal de Saúde , Humanos , Programas de Rastreamento/métodos , Aplicativos Móveis , Pandemias/prevenção & controle , Pneumonia Viral/diagnóstico , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , Vigilância da População/métodos , Software , Triagem
17.
Soins ; 65(842): 22-25, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32245553

RESUMO

The strategic roadmap "Accélérer le virage numérique" presented by the Minister of Health aims to give greater coherence to the development of e-health in France, by developing a clear and shared framework that is likely to strengthen the development of digital uses in health. The Agence nationale d'appui à la performance des établissements de santé et médico-sociaux is fully in line with this approach, in particular by coordinating a vast professional network on this topic.


Assuntos
Tecnologia Biomédica/tendências , Telemedicina/organização & administração , França , Humanos
18.
Soins ; 65(842): 46-47, 2020.
Artigo em Francês | MEDLINE | ID: mdl-32245559

RESUMO

The e-track, a real challenge for caregivers. We have known for more than twenty years that in order to "defragment" healthcare plan, break down the barriers between the city and the hospital and improve coordination between healthcare professionals, a better flow and sharing of information is essential. We are now talking about a digital shift in the light of accelerating technical progress with the rapid adoption of smartphones and mobile applications, and now the themes of big data and artificial intelligence, which are very present in the media.


Assuntos
Tecnologia Biomédica/tendências , Assistência à Saúde/organização & administração , Inteligência Artificial , Humanos , Aplicativos Móveis
19.
PLoS One ; 15(4): e0227593, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32294089

RESUMO

Genomic editing technologies are developing rapidly, promising significant developments for biomedicine, agriculture and other fields. In the present investigation, we analyzed and compared the process of innovation for six genomic technologies: viral vectors, RNAi, TALENs, meganucleases, ZFNs and CRISPR/Cas including the profile of the main research institutions and their funders, to understand how innovation evolved and what institutions influenced research trajectories. A Web of Science search of papers on viral vectors RNAi, CRISPR/Cas, TALENs, ZFNs and meganucleases was used to build a citation network of 16,746 papers. An analysis of network clustering combined with text mining was performed. For viral vectors, a long-term process of incremental innovation was identified, which was largely publicly funded in the United States and the European Union. The trajectory of RNAi research included clusters related to the study of RNAi as a biological phenomenon and its use in functional genomics, biomedicine and pest control. A British philanthropic organization and a US pharmaceutical company played a key role in the development of basic RNAi research and clinical application respectively, in addition to government and academic institutions. In the case of CRISPR/Cas research, basic science discoveries led to the technical improvements, and these two in turn provided the information required for the development of biomedical, agricultural, livestock and industrial applications. The trajectory of CRISPR/Cas research exhibits a geopolitical division of the investigation efforts between the US, as the main producer and funder of basic research and technical improvements, and Chinese research institutions increasingly leading applied research. Our results reflect a change in the model for financing science, with reduced public financing for basic science and applied research on publicly funded technological developments in the US, and the emergence of China as a scientific superpower, with implications for the development of applications of genomic technologies.


Assuntos
Pesquisa Biomédica/tendências , Tecnologia Biomédica/tendências , Organização do Financiamento/tendências , Edição de Genes/tendências , Invenções/tendências , Pesquisa Biomédica/economia , Pesquisa Biomédica/métodos , Pesquisa Biomédica/organização & administração , Tecnologia Biomédica/economia , Tecnologia Biomédica/métodos , Tecnologia Biomédica/organização & administração , Sistemas CRISPR-Cas , China , Organização do Financiamento/economia , Organização do Financiamento/métodos , Edição de Genes/economia , Edição de Genes/métodos , Vetores Genéticos , Invenções/economia , Liderança , Política , Interferência de RNA , Estados Unidos , Vírus/genética
20.
J Med Chem ; 63(15): 8003-8024, 2020 08 13.
Artigo em Inglês | MEDLINE | ID: mdl-32255358

RESUMO

Most of the biomedical materials printed using 3D bioprinting are static and are unable to alter/transform with dynamic changes in the internal environment of the body. The emergence of four-dimensional (4D) printing addresses this problem. By preprogramming dynamic polymer materials and their nanocomposites, 4D printing is able to produce the desired shapes or transform functions under specific conditions or stimuli to better adapt to the surrounding environment. In this review, the current and potential applications of 4D-printed materials are introduced in different aspects of the biomedical field, e.g., tissue engineering, drug delivery, and sensors. In addition, the existing limitations and possible solutions are discussed. Finally, the current limitations of 4D-printed materials along with their future perspective are presented to provide a basis for future research.


Assuntos
Materiais Biocompatíveis/química , Tecnologia Biomédica/métodos , Bioimpressão/métodos , Engenharia Tecidual/métodos , Animais , Tecnologia Biomédica/tendências , Bioimpressão/tendências , Previsões , Humanos , Impressão Tridimensional/tendências , Engenharia Tecidual/tendências
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