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1.
Molecules ; 26(8)2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-33924345

RESUMO

Theranostics is a precision medicine which integrates diagnostic nuclear medicine and radionuclide therapy for various cancers throughout body using suitable tracers and treatment that target specific biological pathways or receptors. This review covers traditional theranostics for thyroid cancer and pheochromocytoma with radioiodine compounds. In addition, recent theranostics of radioimmunotherapy for non-Hodgkin lymphoma, and treatment of bone metastasis using bone seeking radiopharmaceuticals are described. Furthermore, new radiopharmaceuticals for prostatic cancer and pancreatic cancer have been added. Of particular, F-18 Fluoro-2-Deoxyglucose (FDG) Positron Emission Tomography (PET) is often used for treatment monitoring and estimating patient outcome. A recent clinical study highlighted the ability of alpha-radiotherapy with high linear energy transfer (LET) to overcome treatment resistance to beta--particle therapy. Theranostics will become an ever-increasing part of clinical nuclear medicine.


Assuntos
Radioisótopos/uso terapêutico , Terapêutica/métodos , Animais , Fluordesoxiglucose F18/análise , Humanos , Neoplasias/diagnóstico por imagem , Neoplasias/terapia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
2.
Sleep Med Clin ; 16(1): 203-211, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33485528

RESUMO

There are several novel and emerging treatments for obstructive sleep apnea (OSA), including new devices and pharmacotherapies. Long-term efficacy and adherence data for these interventions in the sleep context are lacking. Future studies exploring the long-term adherence and efficacy in novel and emerging treatments of OSA are required to fully understand the place of these treatments in treatment hierarchies. Such research also should aim to evaluate the use of these novel therapies in real-world clinical settings, because many of the studies performed to date have been done under closely monitored research populations and relatively small sample sizes.


Assuntos
Cooperação do Paciente/estatística & dados numéricos , Apneia Obstrutiva do Sono/terapia , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Terapêutica/métodos
3.
Rev. medica electron ; 42(6): 2644-2658, nov.-dic. 2020. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1150044

RESUMO

RESUMEN La enfermedad de Parkinson según la Organización Mundial de Salud, en el año 2016, afectó una persona por cada 100 mayores de 60 años, siendo en cifras absolutas 6,3 millones de personas, y para el año 2030 serán aproximadamente 12 millones de personas en todo el mundo con dicha patología. Este desorden neurodegenerativo, caracterizado por la degradación nigro-estriatal y potenciación de la vía indirecta del circuito motor de los Ganglios Basales sumado al acúmulo de Cuerpos de Lewy en diversas estructuras del Sistema Nervioso Central, afecta progresiva e inevitablemente la calidad de vida de los pacientes, los procederes ablativos del núcleo subtalámico constituyen una alternativa que propicia efecto y seguridad probada en el control de los síntomas de esta enfermedad. Por lo cual se decide describir la ablación del Núcleo subtalámico como tratamiento de la Enfermedad de Parkinson avanzada (AU).


Summary According to the World Health Organization, in 2016 Parkinson's disease affected one person per every 100 people elder 60 years, meaning 6.3 millions of people, and by 2030 it will be around 12 million persons across the world. This neurodegenerative disorder, characterized by the nigro-striatal degradation and potentiation of the indirect route of the basal ganglia motor circuit, added to the accumulation of Lewy bodies in several structures of the Central Nervous System, progressively and inevitably affects the life quality of patients. The ablative procedures of the subthalamic nucleus are an alternative that propitiates proven effect and safety in the control of this disease symptoms. Therefore, the authors decided to describe the subthalamic nucleus ablation as a treatment for advanced Parkinson's disease (AU).


Assuntos
Humanos , Masculino , Feminino , Doença de Parkinson/cirurgia , Núcleo Subtalâmico/cirurgia , Doença de Parkinson/complicações , Doença de Parkinson/diagnóstico , Qualidade de Vida , Procedimentos Cirúrgicos Operatórios/métodos , Terapêutica/métodos , Sistema Nervoso Central/anormalidades
5.
Value Health ; 23(10): 1384-1390, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33032783

RESUMO

OBJECTIVES: This study aimed to investigate whether there was a difference in willingness to pay (WTP) between prevention and treatment for health benefits of equal magnitude. METHODS: We used a web-based survey instrument in a sample of the Swedish general population to perform a contingent valuation study assessing the WTP for prevention and treatment. We analyzed the WTP as a continuous variable using a two-part regression model to adjust for a mass point around 0 and a skewed distribution among respondents with a positive WTP. RESULTS: The study found that people were less willing, on average, to pay at all for prevention than treatment, but those who were willing to pay for prevention had a higher WTP than for treatment. The latter effect was more substantial, and in total mean WTP for prevention was about 85% higher than for treatment. CONCLUSIONS: The findings from this study contribute to the ongoing discussion on the appropriate cost-effectiveness thresholds by adding prevention as a parameter affecting the demand-side value of health improvements. As such, it can provide support to decision makers in healthcare and in health promotion priority setting.


Assuntos
Custos de Cuidados de Saúde , Preferência do Paciente/economia , Medicina Preventiva/economia , Terapêutica/economia , Feminino , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Preferência do Paciente/psicologia , Preferência do Paciente/estatística & dados numéricos , Medicina Preventiva/métodos , Inquéritos e Questionários , Suécia , Terapêutica/métodos , Estados Unidos
6.
Small ; 16(47): e2004551, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33125185

RESUMO

Water-splitting has been extensively studied especially for energy applications. It is often not paid with enough attention for biomedical applications. In fact, several innovative breakthroughs have been achieved in the past few years by employing water-splitting for treating cancer and other diseases. Interestingly, among these important works, only two reports have mentioned the term "water-splitting." For this reason, the importance of water-splitting for biomedical applications is significantly underestimated. This progress work is written with the aims to explain and summarize how the principle of water-splitting is employed to achieve therapeutic results not offered by conventional approaches. It is expected that this progress report will not only explain the importance of water-splitting to scientists in the biomedical fields, it should also draw attention from scientists working on energy applications of water-splitting.


Assuntos
Terapêutica , Água , Tecnologia Biomédica/métodos , Tecnologia Biomédica/tendências , Neoplasias/terapia , Terapêutica/métodos , Terapêutica/tendências , Água/química
7.
Viruses ; 12(10)2020 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-33096825

RESUMO

Most cells can release extracellular vesicles (EVs), membrane vesicles containing various proteins, nucleic acids, enzymes, and signaling molecules. The exchange of EVs between cells facilitates intercellular communication, amplification of cellular responses, immune response modulation, and perhaps alterations in viral pathogenicity. EVs serve a dual role in inhibiting or enhancing viral infection and pathogenesis. This review examines the current literature on EVs to explore the complex role of EVs in the enhancement, inhibition, and potential use as a nanotherapeutic against clinically relevant viruses, focusing on neurotropic viruses: Zika virus (ZIKV) and human immunodeficiency virus (HIV). Overall, this review's scope will elaborate on EV-based mechanisms, which impact viral pathogenicity, facilitate viral spread, and modulate antiviral immune responses.


Assuntos
Vesículas Extracelulares/metabolismo , Viroses/metabolismo , Antivirais/farmacologia , Comunicação Celular/fisiologia , Coronavirus/metabolismo , Coronavirus/patogenicidade , Exossomos/metabolismo , HIV/metabolismo , HIV/patogenicidade , Infecções por HIV/metabolismo , Humanos , Retroviridae/metabolismo , Simplexvirus/metabolismo , Terapêutica/métodos , Viroses/tratamento farmacológico , Viroses/virologia , Zika virus/metabolismo , Zika virus/patogenicidade , Infecção por Zika virus/metabolismo
8.
Rev. cuba. med. mil ; 49(3): e471, jul.-set. 2020.
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1144492

RESUMO

El desarrollo y aplicación de la tecnología en la medicina ha creado dilemas éticos para los galenos, al tener que definir hasta qué punto es ético someter a un paciente a una técnica quirúrgica o un procedimiento endoscópico que presente una alta incidencia de complicaciones cuando pueden existir otros con mejores resultados. En este trabajo se analizan los efectos beneficiosos y nocivos de los adelantes tecnológicos para las ciencias médicas, de ahí que el objetivo fue identificar la influencia de la revolución científico técnica en el desarrollo de la cirugía endoscópica endoluminal. Se analiza cómo el médico debe mantener un equilibrio entre la ciencia y la ética, que le permita, además de ser acertado en el diagnóstico y el tratamiento, ser más humano y comprensivo con sus pacientes. Se concluye que la revolución científica técnica de hoy, que integra conocimientos y experiencia, ha dado solidez al cómo hacer y por qué. Sin embargo, los recursos en ocasiones pueden ser limitados. Ello significa que no siempre se puede realizar todo lo que es técnicamente factible. Las buenas prácticas médicas deben acompañar a todos los galenos a sabiendas de que es la vida de un ser humano que ha confiado en sus capacidades intelectuales y buen poder de decisión(AU)


The development and application of technology in medicine has created ethical dilemmas for physicians to define to what extent it is ethical to subject a patient to a surgical technique or an endoscopic procedure that presents a high incidence of complications when there may be others with best results. In this work the beneficial and harmful effects of the technological advancements for the Medical Sciences are analyzed, for that reason the objective of the same one was to identify the influence of the Technical Scientific Revolution in the development of the Endoluminal Endoscopic Surgery. It is analyzed how the doctor must maintain a balance between science and ethics, which allows him, in addition to being successful in diagnosis and treatment, to be more human and understanding with his patients. It is concluded that the technical scientific revolution of today, which integrates knowledge and experience, has given solidity to how to do and why. However, resources can sometimes be limited. This means that everything that is technically feasible cannot always be done. Good medical practices should accompany all physicians knowing that it is the life of a human being who has relied on their intellectual abilities and good decision-making power(AU)


Assuntos
Humanos , Tecnologia , Terapêutica/métodos , Desenvolvimento Tecnológico , Endoscopia/instrumentação
9.
Med Decis Making ; 40(5): 644-654, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32659160

RESUMO

Objective. In evidence synthesis, therapeutic options have to be compared despite the lack of head-to-head trials. Indirect comparisons are then widely used, although little is known about their performance in situations where cross-trial differences or effect modification are present. Methods. We contrast the matching adjusted indirect comparison (MAIC), simulated treatment comparison (STC), and the method of Bucher using a simulation study. The different methods are evaluated according to their power and type I error rate as well as with respect to the coverage, bias, and the root mean squared error (RMSE) of the effect estimate for practically relevant scenarios using binary and time-to-event endpoints. In addition, we investigate how the power planned for the head-to-head trials influences the actual power of the indirect comparison. Results. Indirect comparisons are considerably underpowered. None of the methods had substantially superior performance. In situations without cross-trial differences and effect modification, MAIC and Bucher led to similar results, while Bucher has the advantage of preserving the within-study randomization. MAIC and STC could enhance power in some scenarios but at the cost of a potential type I error inflation. Adjusting MAIC and STC for confounders that did not modify the effect led to higher bias and RMSE. Conclusion. The choice of effect modifiers in MAIC and STC influences the precision of the indirect comparison. Therefore, a careful selection of effect modifiers is warranted. In addition, missed differences between trials may lead to low power and partly high bias for all considered methods, and thus, results of indirect comparisons should be interpreted with caution.


Assuntos
Simulação por Computador/normas , Terapêutica/normas , Pesquisa Comparativa da Efetividade/métodos , Simulação por Computador/estatística & dados numéricos , Humanos , Psicometria/instrumentação , Psicometria/métodos , Terapêutica/métodos , Terapêutica/estatística & dados numéricos
10.
Aust J Gen Pract ; 49(7): 412-415, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32599994

RESUMO

BACKGROUND: Medical management is undeniably an important therapeutic intervention for selected sexual dysfunctions, but it does not serve as a stand-alone approach to treat many common sexual dysfunctions such as lack of interest in sex, sexual performance anxiety, inability to reach orgasm or too quick an orgasm. OBJECTIVE: The aim of this article is to highlight the role of general practitioners (GPs) in recognising sexual problems, encourage initiation of conversation about sexual dysfunction with patients and raise awareness of sex therapy and presentations that may benefit from referral to sex therapists. DISCUSSION: GPs in Australia have a significant role in addressing sexual health concerns despite practice-related and doctor-patient-related barriers, thereby promoting the healthy sexuality of Australians. Sex therapy is a specialty comprised of various medical, cognitive, emotional and behavioural interventions. Sex therapists, who are healthcare professionals with tertiary training in human sexuality, can share care with GPs to help individuals and/or couples understand, improve and resolve their sexual dysfunctions.


Assuntos
Papel Profissional , Disfunções Sexuais Fisiológicas/terapia , Disfunções Sexuais Psicogênicas/terapia , Terapêutica/métodos , Atitude do Pessoal de Saúde , Austrália , Clínicos Gerais/tendências , Humanos , Relações Médico-Paciente , Disfunções Sexuais Fisiológicas/psicologia , Disfunções Sexuais Psicogênicas/psicologia , Inquéritos e Questionários , Terapêutica/tendências
11.
Rev. bras. cir. plást ; 35(2): 243-248, apr.-jun. 2020. ilus
Artigo em Inglês, Português | LILACS | ID: biblio-1103839

RESUMO

A pele de tilápia possui microbiota não infecciosa e estrutura morfológica semelhante à pele humana. Estudos clínicos fase II, ainda não publicados, mostraram resultados promissores na sua utilização para tratamento de queimaduras. Nos protocolos destes estudos, pacientes com lesões em áreas de dobras de pele, como genitais e região inguinal, foram excluídos, pois achava-se que o biomaterial não aderiria apropriadamente, resultando em um grau de cicatrização inferior. Relato de caso de paciente do sexo feminino, 18 anos, sem comorbidades, com queimaduras de segundo grau profundo em abdômen, região inguinal, parte da genitália e metade superior de ambas as coxas, envolvendo 13,5% da área total da superfície corporal. A pele de tilápia foi aplicada nas lesões levando a uma reepitelização completa com 16 dias de tratamento. Não foram observados efeitos colaterais. A pele de tilápia traz, portanto, a promessa de um produto inovador, de fácil aplicação e alta disponibilidade, que pode se tornar a primeira pele animal nacionalmente estudada e registrada pela Agência Nacional de Vigilância Sanitária, para uso no tratamento de queimaduras. Este relato de caso contribui para reduzir as limitações em relação às áreas anatômicas apropriadas para a aplicação da pele de tilápia, uma vez que, mesmo com a necessidade de reposição de pele, foram obtidos bons resultados com aplicação na genitália e região inguinal.


Tilapia skin has a non-infectious microbiota and a morphological structure similar to human skin. Phase II clinical studies, not yet published, have shown promising results in their use for the treatment of burns. In the protocols of these studies, patients with lesions in areas of skin folds, such as genitals and inguinal regions, were excluded, as it was thought that the biomaterial would not adhere properly, resulting in a lower degree of healing. Case report of a female patient, 18 years old, without comorbidities, with deep second-degree burns in the abdomen, inguinal region, part of the genitalia and upper half of both thighs, involving 13.5% of the total body surface area. Tilapia skin was applied to the lesions leading to a complete re-epithelialization with 16 days of treatment. No side effects were observed. Tilapia skin, therefore, brings the promise of an innovative product, easy to apply, and highly available, which can become the first animal skin nationally studied and registered by the Agência Nacional de Vigilância Sanitária, for use in the treatment of burns. This case report contributes to reduce the limitations concerning the anatomical areas appropriate for the application of tilapia skin, since, even with the need for skin replacement, good results were obtained with application to the genitalia and inguinal region.


Assuntos
Humanos , Feminino , Adolescente , História do Século XXI , Terapêutica , Transplante Autólogo , Curativos Biológicos , Queimaduras , Relatos de Casos , Condutas Terapêuticas , Tilápia , Ciclídeos , Abdome , Estudo Clínico , Genitália , Quadril , Terapêutica/métodos , Transplante Autólogo/métodos , Transplante Autólogo/reabilitação , Curativos Biológicos/normas , Queimaduras/terapia , Condutas Terapêuticas/efeitos adversos , Condutas Terapêuticas/normas , Tilápia/anatomia & histologia , Ciclídeos/anatomia & histologia , Genitália/anatomia & histologia , Abdome/anatomia & histologia , Quadril/anatomia & histologia
12.
Farm. hosp ; 44(3): 109-113, mayo-jun. 2020.
Artigo em Espanhol | IBECS | ID: ibc-192343

RESUMO

Existen dimensiones relevantes desde una perspectiva de género relaciona-das con el esfuerzo terapéutico. Se pretende ilustrar y traer a debate posibles sesgos de género relacionados con los medicamentos, mediante el análisis del consumo en las mujeres, la prescripción de fármacos biológicos según sexo, la potencial desigualdad de género en las reacciones adversas a los medicamentos y la investigación con ensayos clínicos, así como las decisiones de las instituciones internacionales en la comercialización de medicamentos. mSe observa una mayor tendencia a prescribir analgésicos, con independencia del dolor, y fármacos para síntomas depresivos de baja intensidad en mujeres que en hombres. Lo contrario sucede en la prescripción de estatinas y dosis adecuadas, y con la mayor probabilidad de prescripción de antifactor de necrosis tumoral en hombres que en mujeres con espondilitis anquilosante, pese a la similar carga de la enfermedad. Las reacciones adversas a los medicamentos se observan con más frecuencia en mujeres que en hombres, donde determinantes como el peso corporal están influyendo poco en la dosificación. En la actualidad se considera escasamente en la prescripción que las mujeres presentan diferencias en la actividad de las enzimas del citocromo CYPP450, que puede afectar a la velocidad del metabolismo hepático. Incluso hay efectos inmunológicos, genéticos y epigenéticos (por la herencia y la dosificación desigual de los genes ubicados en los cromosomas X e Y) que pueden influir en estas diferencias por sexo. Por último, mediante los casos de ensayos clínicos de la terapia hormonal, un fármaco para el deseo sexual inhibido de las mujeres y un anticonceptivo para hombres, se muestran sesgos y estereotipos de género que influyen en una potencial generación de desigualdades, especialmente en las reacciones adversas a los medicamentos en perjuicio de las mujeres. Concluyendo, los profesionales sanitarios atribuyen con frecuencia a la emocionalidad de las mujeres lo que son síntomas físicos, influyendo en la mayor prescripción de fármacos sintomáticos en ellas. Debe analizarse si la misma razón influye en la menor prescripción de fármacos terapéuticos en mujeres que en hombres. Existen determinantes biológicos a considerar por su influencia en una mayor toxicidad farmacológica en las mujeres. Los ensayos clínicos deben mejorar atendiendo a las recomendaciones de género de la Food and Drug Administration


There are relevant dimensions from a gender perspective related to the-rapeutic effort. To illustrate and discuss possible gender bias related to medicines, through the consumption analysis in women, the prescription of biological drugs according to sex, the potential gender inequality in adverse drug reactions, and research with clinical trials, as well as the decisions of international institutions in the marketing of medicinal products.There is greater tendency to prescribe pain relievers, regardless of pain, and drugs for low intensity depressive symptoms in women than in men. The opposite occurs in the prescription of statins and adequate doses, and with the greater probability of prescribing anti-tumor necrosis factor in men than in women with ankylosing spondylitis, despite a similar disease burden. Adverse drug reactions are observed more frequently in women than in men, where determinants such as body weight are having little influence on the dosage. It is currently scarcely considered in the prescrip-tion that women have differences in the activity of cytochrome CYPP450 enzymes, which can affect the liver's metabolism rate. There are even immunological, genetic and epigenetic effects (due to heredity and une-ven gene dosing located in the X and Y chromosomes) that can influence these differences by sex. Finally, through cases of hormonal therapy clini-cal trials, a drug for women's inhibited sexual desire and a contraceptive for men, gender bias and stereotypes are shown to influence a potential generation of inequalities, especially in adverse drug reactions to the de-triment of women. In conclusion, health professionals frequently attribute physical symptoms to women's emotionality, influencing their greater prescription of sympto-matic drugs. Whether the same reason influences the lower prescription of therapeutic drugs in women than in men should be analyzed. There are biological determinants to consider due to their influence on a greater pharmacological toxicity in women. Clinical trials should improve accor-ding to the gender recommendations by the Food and Drugs Administration


Assuntos
Humanos , Iniquidade de Gênero , Pesquisa Biomédica , Terapêutica/métodos , Ensaios Clínicos como Assunto/estatística & dados numéricos , Garantia da Qualidade dos Cuidados de Saúde , Preconceito , Estereotipagem de Gênero , Prescrições de Medicamentos
13.
J Evid Based Med ; 13(2): 130-136, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32445266

RESUMO

This narrative review is an introduction for health professionals on how to conduct and report clinical research on six categories: treatment, diagnosis/differential diagnosis, prognosis, etiology, screening, and prevention. The importance of beginning with an appropriate clinical question and the exploration of how appropriate it is through a literature search are explained. There are three methodological directives that can assist clinicians in conducting their studies from a methodological perspective: (1) how to conduct an original study or a systematic review, (2) how to report an original study or a systematic review, and (3) how to assess the quality or risk of bias for a previous relevant original study or systematic review. This methodological overview article would provide readers with the key points and resources regarding how to perform high-quality research on the six main clinical categories.


Assuntos
Pesquisa Biomédica/métodos , Diagnóstico , Medicina Preventiva/métodos , Terapêutica/métodos , Pesquisa Biomédica/normas , Causalidade , Humanos , Programas de Rastreamento , Prognóstico , Revisões Sistemáticas como Assunto
14.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-47243

RESUMO

O Ministério da Saúde tem apoiado instituições e monitorado diariamente pesquisas que objetivam identificar um tratamento efetivo para a COVID-19. Entre elas, em especial um consórcio de estudos que utilizará o plasma sanguíneo convalescente de pacientes recuperados da doença


Assuntos
Plasma/virologia , Terapêutica/métodos , Coronavirus , Transfusão de Sangue , Monitoramento
15.
Rev. medica electron ; 42(2): 1735-1742, mar.-abr. 2020. graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1127031

RESUMO

Resumen Las fracturas del Atlas representan el segundo tipo más común de lesiones de la columna cervical alta. Con este trabajo se persigue describir la fijación occipito-cervical como tratamiento de la fractura de atlas tipo Jefferson inestable. Se presenta paciente que sufre trauma raquimedular, después de aplicarle un minucioso examen físico y la tomografía axial computada de columna cervical se detecta una fractura tipo Jefferson de atlas con más de 7 mm de separación de sus fragmentos. Al ser esta una fractura inestable de la región cervical alta se decide realizar una fijación occipito-cervical como método de tratamiento de esta lesión. La evolución postquirúrgica del paciente transcurrió sin complicaciones (AU).


Summary Atlas fractures represent the second most common type of upper cervical spine injury. This work aims to describe the occipito-cervical fixation as a treatment for the unstable Jefferson-type atlas fracture. A patient suffering from spinal cord trauma is presented, after applying a thorough physical examination and the computed tomography of the cervical spine, a Jefferson type fracture of atlas with more than 7 mm of separation of its fragments is detected. As this is an unstable fracture of the upper cervical region, it was decided to perform an occipito-cervical fixation as a treatment method for this lesion. The postoperative evolution of the patient was uneventful (AU).


Assuntos
Humanos , Masculino , Adulto , Atlas Cervical/lesões , Terapêutica/métodos , Dispositivos de Fixação Ortopédica , Tomografia/métodos , Métodos , Fraturas Ósseas/diagnóstico , Fraturas Ósseas/terapia
16.
Fertil Steril ; 113(3): 489-499, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32192588

RESUMO

Globally, male factor infertility accounts for 20%-70% of couples struggling to conceive. Certain male pediatric developmental conditions, such as cryptorchidism, hypospadias, testicular and other childhood cancers, infections, and pediatric varicocele have been associated with future infertility. Early fertility preservation, especially in those with pending chemotherapy or genetic conditions such as Klinefelter syndrome, should be strongly considered in patients expected to experience testicular loss. Although optimal treatment timing may be unknown owing to a paucity of long-term prospective studies, early diagnosis and targeted treatment may optimize fertility potential in adulthood.


Assuntos
Preservação da Fertilidade/normas , Infertilidade Masculina/prevenção & controle , Pediatria/métodos , Saúde Reprodutiva/normas , Calibragem , Criança , Fertilidade/fisiologia , Preservação da Fertilidade/métodos , Preservação da Fertilidade/tendências , Humanos , Masculino , Pediatria/tendências , Medicina Reprodutiva/normas , Terapêutica/métodos , Terapêutica/normas , Terapêutica/tendências , Resultado do Tratamento
18.
Rev Bras Enferm ; 73(1): e20180134, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32049227

RESUMO

OBJECTIVE: to discuss the intersection between being a nurse/being a therapist in the mental health field. METHOD: exploratory, qualitative study based on a self-report interview conducted with ten nurses from a psychiatric hospital in Rio de Janeiro between June and July 2017. Data were analyzed in the light of Travelbee's theory. RESULTS: Nurses consider themselves therapists because of actions performed in mental health care practice, despite the theoretical fragmentation of interpersonal relationships identified in the distance from the promotion of self-knowledge, which is an essential element in the psychotherapeutic process. FINAL CONSIDERATIONS: the strong relationship between being and doing in nursing stands out and favors the development of satisfactory therapeutic relationships with the hospitalized person.


Assuntos
Serviços de Saúde Mental , Papel do Profissional de Enfermagem/psicologia , Terapêutica/métodos , Adulto , Brasil , Feminino , Humanos , Entrevistas como Assunto/métodos , Pessoa de Meia-Idade , Enfermeiras e Enfermeiros/psicologia , Pesquisa Qualitativa , Terapêutica/psicologia , Terapêutica/estatística & dados numéricos
20.
Clin Chim Acta ; 503: 90-98, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31968211

RESUMO

Fecal microbiota transplantation (FMT) is the introduction (transplantation) of gut microbiota obtained from the faeces of a healthy donor into the patient's gastrointestinal tract. Most often, such therapy is used the treatment of gastrointestinal diseases caused by the activity of pathogenic or conditionally pathogenic microorganisms, however, recently an increasing number of studies have reported the use of fecal microbiota transplantation for the treatment of diseases such as metabolic syndrome, diabetes, cancer and Parkinson's disease. This review article presents the results of studies concerning the impact of FMT on weight gain, immunological response and the treatment of neurological and gastrointestinal diseases and cancer. The procedure of fecal microbiota transplantation and possible side effects that may appear in FMT recipients are also described.


Assuntos
Transplante de Microbiota Fecal/métodos , Terapêutica/métodos , Transplante de Microbiota Fecal/efeitos adversos , Gastroenteropatias/terapia , Humanos , Síndrome Metabólica/terapia , Neoplasias/terapia , Doenças do Sistema Nervoso/terapia , Doença de Parkinson/terapia , Terapêutica/efeitos adversos
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