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1.
J Dermatol ; 46(10): 843-848, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31389056

RESUMO

Phakomatosis pigmentovascularis is a rare syndrome characterized by widespread capillary malformation and pigmented nevus. The objective of this study was to evaluate its characteristics and treatment. Fifty-two patients presenting between 2003 and 2017 were retrospectively reviewed. Type IIa (port-wine stain and dermal melanocytosis with oculocutaneous involvement) was most common. Systemic involvement was observed in 17.3% and it was not significantly correlated to extent of capillary malformation or pigmented nevus. However, systemic involvement was significantly frequent in patients with nevus of Ota and in patients with pigmented nevus located on the head and neck (P = 0.004 and 0.035, respectively). Capillary malformation was almost cleared in 28.6% of patients using pulsed dye laser, whereas pigmented nevus was almost cleared in 23.7% and completely cleared in 42.1% of patients using Q-switched neodymium:yttrium-aluminum-garnet laser. Treatment outcome score showed significant inverse correlation with the extent of port-wine stain or pigmented nevus (P = 0.047, ρ = -0.308 and P = 0.011, ρ = -0.410, respectively). Pigmented nevus demonstrated better treatment response to lasers than did capillary malformation. Smaller lesions tended to show better treatment outcomes for both capillary malformation and pigmented nevus.


Assuntos
Terapia com Luz de Baixa Intensidade/métodos , Síndromes Neurocutâneas/diagnóstico , Nevo de Ota/diagnóstico , Mancha Vinho do Porto/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Lasers de Corante/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Masculino , Pessoa de Meia-Idade , Síndromes Neurocutâneas/complicações , Síndromes Neurocutâneas/radioterapia , Nevo de Ota/etiologia , Nevo de Ota/radioterapia , Mancha Vinho do Porto/etiologia , Mancha Vinho do Porto/radioterapia , Estudos Retrospectivos , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/radioterapia , Resultado do Tratamento , Adulto Jovem
2.
Int J Dermatol ; 58(10): 1212-1222, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31297798

RESUMO

BACKGROUND: Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory; instead, employing multiple modalities may have better outcome. Autologous adipose tissue-derived adult stem cells (AT-ASCs) and their secretory factors can stimulate collagen synthesis; angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also, conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. The aim of the study was to verify the effectiveness of AT-ASCs for the treatment of acne scarring vs. the fractional carbon dioxide laser (FxCR). SUBJECTS AND METHODS: Split face comparative study included 10 adult patients with post-acne scars on both sides of the face. One side received AT-ASCs single injection while the other received three sessions of FxCR. Scars were then assessed using the global scoring system Goodman and Baron, scar area percent using NIH ImageJ software and functional assessment by measuring the transepidermal water loss (TEWL) and skin hydration. Both sides were followed for three months. RESULTS: A significant improvement in the degree of scar severity, scar area percent, skin hydration, and TEWL after 3 months of treatment on both sides of the face with insignificant differences between both treatment modalities, provided that AT-ASCs treatment was employed once vs. three sessions of FxCR. CONCLUSION: One injection of AT-ASCs is as effective as three sessions of FxCR in the treatment of atrophic acne scars.


Assuntos
Acne Vulgar/complicações , Células-Tronco Adultas/transplante , Cicatriz/terapia , Terapia com Luz de Baixa Intensidade/métodos , Transplante de Células-Tronco/métodos , Tecido Adiposo/citologia , Adulto , Cicatriz/diagnóstico , Cicatriz/etiologia , Feminino , Seguimentos , Humanos , Lasers de Gás/efeitos adversos , Lipectomia/métodos , Terapia com Luz de Baixa Intensidade/efeitos adversos , Terapia com Luz de Baixa Intensidade/instrumentação , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Índice de Gravidade de Doença , Pele/patologia , Pele/efeitos da radiação , Fatores de Tempo , Transplante Autólogo/métodos , Resultado do Tratamento , Perda Insensível de Água/efeitos da radiação , Adulto Jovem
3.
Am J Clin Dermatol ; 20(5): 683-690, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31327129

RESUMO

Over the past 30 years, the treatment of acne scars has undergone changes that have been significantly influenced by the concurrent development of new devices. The advent of fractional resurfacing lasers was a watershed moment for acne scarring therapy. The author recounts a career history of considerations of acne scarring treatments as well as the literature supporting the experiences causing changes in practice. Fractional ablative and nonablative lasers, sublative radiofrequency, picosecond lasers, microneedling with and without radiofrequency and fillers are the bulk of the treatments covered, along with a discussion of combination therapy. A practical algorithm for acne scarring for selection of treatment modalities is presented.


Assuntos
Acne Vulgar/complicações , Cicatriz/terapia , Dermatologia/métodos , Técnicas de Ablação/instrumentação , Técnicas de Ablação/métodos , Adolescente , Adulto , Algoritmos , Criança , Cicatriz/etiologia , Cicatriz/patologia , Terapia Combinada/métodos , Preenchedores Dérmicos/administração & dosagem , Dermatologia/história , Dermatologia/instrumentação , Feminino , História do Século XX , História do Século XXI , Humanos , Lasers , Terapia com Luz de Baixa Intensidade/instrumentação , Terapia com Luz de Baixa Intensidade/métodos , Agulhas , Plasma Rico em Plaquetas , Terapia por Radiofrequência/instrumentação , Terapia por Radiofrequência/métodos , Pele/efeitos dos fármacos , Pele/patologia , Pele/efeitos da radiação , Resultado do Tratamento , Adulto Jovem
4.
Medicina (Kaunas) ; 55(8)2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31344985

RESUMO

Background and objectives: Diode laser has been the most popular low-level laser therapy (LLLT) technique in dentistry due to its good tissue penetration, lower financial costs, small size for portable application, and convenience to use. A series of recent studies with 940 nm or 980 nm lasers demonstrated that LLLT showed positive effects after third molar extraction or periodontal flap surgery. However, the effects of LLLT on intraoral mucosal wound healing after surgical incision have not yet been determined in human clinical study. Materials and Methods: The present study was performed to determine the efficacy and safety of 915 nm wavelength low-level laser therapy (LLLT) in mucosal wound healing. A total of 108 Sprague-Dawley rats were used. They were divided into three groups: Abrasive wound group, immediate LLLT once group, and daily LLLT group. As a clinical study, a total of 16 patients with split-mouth design subjected to bilateral mandibular third molar extraction were allocated into the LLLT group and placebo group. The process of LLLT was performed on postoperative days 0, 1, and 7, and parameters related to wound healing were analyzed on days 1, 7, and 14. Results: Repeated laser irradiation promoted mucosal wound healing of the rats. In the clinical study, although there were no significant statistical differences between the LLLT and placebo groups in all inflammatory parameters, the early stage mucosal healing tendency of wound dehiscence was higher in the LLLT group than in the placebo group clinically on postoperative day 1. Conclusions: The present results showed that 915 nm LLLT could be applied safely as an auxiliary therapy for mucosal wound healing.


Assuntos
Terapia com Luz de Baixa Intensidade/normas , Membrana Mucosa/lesões , Cicatrização , Adolescente , Adulto , Análise de Variância , Animais , Modelos Animais de Doenças , Método Duplo-Cego , Feminino , Humanos , Terapia com Luz de Baixa Intensidade/instrumentação , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Dente Serotino/lesões , Dente Serotino/efeitos da radiação , Membrana Mucosa/efeitos da radiação , Ratos/lesões , Ratos Sprague-Dawley , República da Coreia , Resultado do Tratamento
5.
J Cosmet Dermatol ; 18(4): 1009-1013, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31245963

RESUMO

BACKGROUND: Alopecia areata (AA) is a relatively common dermatosis with the sudden burst of hair loss on the scalp and other hair-bearing regions. However, because of high relapse and side effects, no satisfactory therapy has been widely accepted. OBJECTIVE: To observe the efficiency and safety of the combination therapy of a nonablative fractional (NAF) laser and topical minoxidil for AA. METHODS: Eight Chinese AA patients were included in this study. These patients received 10 treatments every two weeks. At every time, the subject was given 10 to 15 mJ of energy with a total intensity of 300 spots/cm2 . After the laser treatment, a topical 5% minoxidil tincture was immediately applied twice daily and continued until the final laser treatment. RESULTS: Hair regrowth was observed 1-2 months after treatment. There was complete regrowth in 2 patients, and the lesions of 2 children with alopecia universalis were covered with 30% and 50% regrowth, respectively. All patients except 1 had no relapse at the 1-year follow-up examination. CONCLUSION: The combination of nonablative laser and topical minoxidil may be a good alternative therapy for AA patients, including alopecia totalis and alopecia universalis, without systemic and local side effects.


Assuntos
Alopecia em Áreas/terapia , Alopecia/terapia , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Minoxidil/administração & dosagem , Administração Tópica , Adulto , Alopecia/diagnóstico , Alopecia em Áreas/diagnóstico , Criança , Terapia Combinada , Feminino , Seguimentos , Cabelo/efeitos dos fármacos , Cabelo/efeitos da radiação , Humanos , Masculino , Pessoa de Meia-Idade , Couro Cabeludo , Resultado do Tratamento
6.
Photobiomodul Photomed Laser Surg ; 37(6): 356-361, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31188089

RESUMO

Background: Diode lasers have been used for implant decontamination. However, the use of initiated or noninitiated tips remains unevaluated to verify potential photothermal risks. Objective: To assess the photothermal effects of defocused-initiated versus noninitiated irradiation. Materials and methods: A dental implant (3.5 × 11 mm) was placed into an artificial bone, an infrabony defect was created to simulate a four-wall peri-implant defect. Irradiation was performed using pulsed diode lasers of 940, 975, and 980 nm. The laser tips were positioned parallel to the implant (maximum 2W pulsed mode). The implant was irradiated for 30 sec using noninitiated, cork-, and blue paper-initiated tips. Temperature differences were observed at the apical and coronal regions of the implant. The data were statistically evaluated and compared using one-way analysis of variance and Tukey tests. Results: The average temperature increase and the amount of time that it took to yield the critical temperature were comparable at the coronal level for the 940 and 975 nm diode lasers (p > 0.05). For the 980 nm laser, blue-initiated tip had the highest temperature increase (22.4°C), followed by cork (18.8°C) and noninitiated tip (17.3°C). The critical threshold at the coronal portion for the 980 nm laser was reached in 11.5, 8.79, and 6.46 sec for the blue paper-, cork-, and noninitiated tips, respectively. The 975 and 980 nm lasers had average temperature increases, comparable among the blue paper-, cork-, and noninitiated tips at the apical level (p > 0.05). Apically, for the 940 nm, the noninitiated tip had the highest temperature increase (5.57°C), followed by the cork- (4.96°C) and blue paper-initiated tip (4.54°C). Conclusions: The initiator does not affect the temperatures produced during implant decontamination although noninitiated diode lasers may overheat (within 30 sec) than initiated tips. There is minimal risk of overheating at the apical portion. It seems that the 940 nm diode is the safest of the evaluated laser systems.


Assuntos
Lasers Semicondutores , Terapia com Luz de Baixa Intensidade/instrumentação , Peri-Implantite/prevenção & controle , Descontaminação , Temperatura Ambiente
7.
Drug Dev Ind Pharm ; 45(9): 1487-1495, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31172835

RESUMO

Chemotherapy has been widely used for treatment to malignant cancer, such as hepatocellular carcinoma (HCC). Chemotherapeutic effect was not often efficient to achieve totally tumor ablation due to the poor cellular uptake and drug resistance. To address these problems, a novel nanoplatform was constructed based on nontoxic mesoporous silica nanoparticles (MSNs) for a combined chemo/photothermal therapy to enhance tumor cell accumulation and promote toxicity of chemotherapeutic drugs. Prepared MSNs were consisted of Au nanoshell for photothermal conversion and a first-line anti-HCC drug-sorafenib (SO) for chemotherapy. The SO-Au-MSNs could help SO accumulate more in hepatic cancer cells. Under near infrared irradiation, SO-Au-MSNs exerted a high cell inhibition rate which could be attributed to the enhanced toxicity of SO under hyperthermia and synergistic chemo/photothermal therapy. SO-Au-MSNs showed a good compatibility as well as efficient cell cytotoxicity. Overall, SO-Au-MSNs would be a promising candidate for further enhancing the antitumor effect on HCC.


Assuntos
Antineoplásicos/administração & dosagem , Carcinoma Hepatocelular/terapia , Portadores de Fármacos/química , Hipertermia Induzida/métodos , Neoplasias Hepáticas/terapia , Terapia com Luz de Baixa Intensidade/métodos , Antineoplásicos/farmacocinética , Carcinoma Hepatocelular/patologia , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Terapia Combinada/métodos , Composição de Medicamentos , Liberação Controlada de Fármacos/efeitos da radiação , Ouro/química , Humanos , Hipertermia Induzida/instrumentação , Lasers , Neoplasias Hepáticas/patologia , Terapia com Luz de Baixa Intensidade/instrumentação , Nanopartículas Metálicas/química , Porosidade , Dióxido de Silício/química , Sorafenibe/administração & dosagem , Sorafenibe/farmacocinética
8.
J Cosmet Dermatol ; 18(3): 747-754, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31074085

RESUMO

INTRODUCTION: The purpose of this manuscript is to investigate the treatment of skin soft tissue embolization or vascular occlusion after the injection of hyaluronic acid (HA) for Injection Rhinoplasty (IR) in Asians with a special interest in the time occurrence of the occlusion. METHODS: A total of 35 cases were evaluated after receiving HA injections for IR who presented with a vascular occlusive event. They were divided into three stages based on the time to embolization. Immediate, ≤5 hours; early, ≤3 days; and late, >3 days. There were two cases of immediate, 28 deemed early, and five late. Methods to prevent tissue necrosis are reviewed in the manuscript based on these stages. RESULTS: Skin color gradually recovered to normal after 11 treatments in 11 patients with mild embolization. No ischemic aggravation or skin necrosis was observed in 19 patients with moderate embolization; red scarring was seen in two and hypertrophic scar with uneven skin color in one patient. The five patients in the severe category had longer healing, more red scars, and more hypertrophic scarring. CONCLUSION: The treatment of skin soft tissue embolization or vascular occlusion after HA IR in Asians can be effected by identifying the stage and degree of embolization and treating appropriately with the outlines presented in this manuscript.


Assuntos
Cicatriz Hipertrófica/terapia , Preenchedores Dérmicos/efeitos adversos , Embolia/terapia , Ácido Hialurônico/efeitos adversos , Rinoplastia/efeitos adversos , Adulto , Anti-Inflamatórios/administração & dosagem , Grupo com Ancestrais do Continente Asiático , Cicatriz Hipertrófica/etiologia , Preenchedores Dérmicos/administração & dosagem , Embolia/etiologia , Feminino , Humanos , Ácido Hialurônico/administração & dosagem , Hialuronoglucosaminidase/administração & dosagem , Injeções Subcutâneas/efeitos adversos , Lasers de Corante/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Massagem , Necrose/etiologia , Necrose/terapia , Rinoplastia/métodos , Pele/patologia , Fatores de Tempo , Vasodilatadores/administração & dosagem , Adulto Jovem
9.
Photobiomodul Photomed Laser Surg ; 37(8): 489-494, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31140907

RESUMO

Objective: This study aims to compare the bactericidal efficacy of different Er,Cr:YSGG disinfection methods, particularly combined application of Er,Cr:YSGG and Diode laser. Background: Root canal disinfection is important for long-term endodontic success. Different laser systems are proposed as alternatives to conventional techniques in bacterial elimination. Materials and methods: Ninety-five straight, single-rooted premolars with similar canal dimensions were selected. After the mechanical preparation, the samples were sterilized, and root canals were infected with Enterococcus faecalis. The samples were randomly divided into five groups (n = 15): 5% NaOCl, Er,Cr:YSGG, Er,Cr:YSGG +5% NaOCl, Er,Cr:YSGG + Diode, and control group. Results: The maximal bacterial elimination was observed in Er,Cr:YSGG + NaOCl group (p < 0.005). More bacteria were found in Er,Cr:YSGG and Er,Cr:YSGG + Diode groups compared with 5% NaOCl group (p < 0.005). Marginal significance was detected between the Er,Cr:YSGG group and the Er,Cr:YSGG + Diode group (p = 0.091). Conclusions: The most successful E. faecalis elimination was obtained from laser-activated irrigation group. As combined application of Er,Cr:YSGG and Diode laser gives suggestive results, further studies with larger sample sizes are needed to clarify the outcome.


Assuntos
Cavidade Pulpar/microbiologia , Desinfecção/métodos , Enterococcus faecalis/efeitos da radiação , Lasers Semicondutores , Lasers de Estado Sólido , Terapia com Luz de Baixa Intensidade/instrumentação , Dente Pré-Molar , Humanos , Técnicas In Vitro , Distribuição Aleatória , Irrigantes do Canal Radicular/farmacologia , Preparo de Canal Radicular , Hipoclorito de Sódio/farmacologia
10.
Am J Clin Dermatol ; 20(5): 647-655, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31134589

RESUMO

Advances in laser therapy have led to novel therapeutic approaches to common pediatric skin conditions. As a non-invasive alternative to surgical options, laser therapy is efficacious in treating a broad range of conditions, from vascular and pigmented lesions to tattoo and hair removal. This paper reviews the basic mechanics of laser therapy, its role in common pigmented pediatric dermatoses, and special considerations for this unique age group.


Assuntos
Terapia com Luz de Baixa Intensidade/métodos , Nevo Pigmentado/terapia , Dor/tratamento farmacológico , Transtornos da Pigmentação/terapia , Neoplasias Cutâneas/terapia , Fatores Etários , Anestésicos Locais/administração & dosagem , Criança , Humanos , Lactente , Recém-Nascido , Terapia com Luz de Baixa Intensidade/efeitos adversos , Terapia com Luz de Baixa Intensidade/instrumentação , Dor/etiologia , Manejo da Dor/métodos , Transtornos da Pigmentação/etiologia , Pele/efeitos da radiação , Pigmentação da Pele/efeitos da radiação , Tatuagem/efeitos adversos , Resultado do Tratamento
11.
Photobiomodul Photomed Laser Surg ; 37(2): 85-90, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050927

RESUMO

Objective: The aim of this randomized clinical trial was to evaluate the influence of root canal disinfection with a 940-nm diode laser on the intensity of pain after endodontic retreatment. Background data: Microorganisms are the most common causes of tooth pain. Therefore, clinical studies are needed to explore the effect of disinfection techniques on postoperative pain. Methods: Eighty-four patients scheduled for endodontic retreatment were allocated to two groups in a 1:1 ratio (n = 42 each). After root canal filling removal and chemomechanical procedures, the root canals were disinfected with a 940-nm diode laser in one group [laser disinfection (LD) group]. In the other group, a mock application of laser was made with the power off [pseudo-laser disinfection (PLD) group]. All retreatment procedures were completed in a single visit. The patients assessed their pain levels at 24, 48, and 72 h after retreatment using a numeric rating scale. The number of analgesic pills used during this period was also recorded. The collected data were statistically analyzed using Mann-Whitney U and Wilcoxon tests. Results: Postoperative pain on the first 2 days was significantly lesser in the LD group than in the PLD group (p < 0.05), and the difference became insignificant on the third day (p > 0.05). Moreover, analgesic intake over 3 days and pain on percussion on the fourth day were significantly lesser in the LD group than in the PLD group (p < 0.05). Conclusions: Elimination of microorganisms from root canals is important for preventing postoperative complications. Our findings suggest that diode LD can reduce postoperative pain and provide comfort after endodontic retreatment. This study is registered in www.ClinicalTrials.gov database with the identifier number NCT03584880.


Assuntos
Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Dor Pós-Operatória/prevenção & controle , Obturação do Canal Radicular/efeitos adversos , Preparo de Canal Radicular/instrumentação , Adolescente , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/diagnóstico , Dor Pós-Operatória/etiologia , Adulto Jovem
12.
Photobiomodul Photomed Laser Surg ; 37(1): 4-16, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31050938

RESUMO

Objective: Perform systematic literature review on photobiomodulation (PBM) devices used at home for nonesthetic applications. Background: Home-use PBM devices have been marketed for cosmetic and therapeutic purposes. This is the first systematic literature review for nonesthetic applications. Methods: A systematic literature search was conducted for PBM devices self-applied at home at least thrice a week. Two independent reviewers screened the articles and extracted the data. Treatment dosage appropriateness was compared to the World Association for Laser Therapy (WALT) recommendations. The efficacy was evaluated according to the relevant primary end-point for the specific indication. Results: Eleven studies were suitable. Devices were applied for a range of indications, including pain, cognitive dysfunction, wound healing, diabetic macular edema, and postprocedural side effects, and were mostly based on near-infrared, pulsed light-emitting diodes with dosages within WALT recommendations. Regarding efficacy, studies reported mostly positive results. Conclusions: Home-use PBM devices appear to mediate effective, safe treatments in a variety of conditions that require frequent applications. Conclusive evaluation of their efficacy requires additional, randomized controlled studies.


Assuntos
Terapia com Luz de Baixa Intensidade/instrumentação , Autocuidado/instrumentação , Humanos
13.
Photobiomodul Photomed Laser Surg ; 37(1): 17-24, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31050942

RESUMO

Objective: The objective of the present study was to investigate the application of a carbon arc lamp on wound healing in a rat cutaneous full-thickness wound model. Background data: In clinical practice, wound healing has been promoted by irradiation with a carbon arc lamp. However, the corresponding mechanism has not been clearly defined. Methods: A cutaneous full-thickness wound on the back of rats was irradiated using a carbon arc lamp at a wavelength peak range of 620-740 nm with 54 J/cm2. Injured sham-irradiated control rats were used as the control. The rats were euthanized after 7, 14, and 21 days, while wound reepithelialization and healing quality were examined by histological analyses with comparison between groups. Cell proliferation was observed by 5-bromo-2'-deoxyuridine (BrdU) immunohistochemical staining. Results: Irradiation by the carbon arc lamp significantly accelerated wound healing. The wound-healing rate in the treated group at day 21 was 98.42% ± 0.56%, compared with 93.58% ± 1.26% in the control group (p < 0.05). Significant increases in the length of epithelial edges, collagen content, and microvessel density were observed in the wound sites in the treated group at days 7, 14, and 21 (p < 0.05). Moreover, the number of BrdU-labeled cells increased in the wound edge at days 7 and 14 due to irradiation (p < 0.05). Conclusions: The results demonstrated that the carbon arc lamp can promote wound healing together with improvement in its quality by stimulating cell proliferation.


Assuntos
Terapia com Luz de Baixa Intensidade/instrumentação , Lesões dos Tecidos Moles/radioterapia , Cicatrização/efeitos da radiação , Animais , Carbono , Proliferação de Células , Modelos Animais de Doenças , Masculino , Ratos , Ratos Wistar
14.
J Drugs Dermatol ; 18(4): s138 - 143, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31026130

RESUMO

The following roundtable is edited from discussion between the authors concerning treatment with the 650-microsecond 1064nm Nd:YAG laser. These dermatologist experts share their expertise, experience, and treatment pearls regarding the device for medical and aesthetic use, and in treatment of skin of color (SOC).


Assuntos
Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Envelhecimento da Pele/efeitos da radiação , Pigmentação da Pele/efeitos da radiação , Pele/efeitos da radiação , Acne Vulgar/terapia , Adulto , Feminino , Doenças do Cabelo/terapia , Humanos , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Melanose/terapia , Rejuvenescimento , Luz Solar/efeitos adversos , Resultado do Tratamento
15.
Nat Commun ; 10(1): 1926, 2019 04 26.
Artigo em Inglês | MEDLINE | ID: mdl-31028250

RESUMO

Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cover a clinically relevant area in real-time. Herein, we report the rational design and optimization of fluorescence-Raman bimodal nanoparticles (FRNPs) that synergistically combine the specificity of Raman spectroscopy with the versatility and speed of fluorescence imaging. DNA-enabled molecular engineering allows the rational design of FRNPs with a detection limit as low as 5 × 10-15 M. FRNPs selectively accumulate in tumor tissue mouse cancer models and enable real-time fluorescence imaging for tumor detection, resection, and subsequent Raman-based verification of clean margins. Furthermore, FRNPs enable highly efficient image-guided photothermal ablation of tumors, widening the scope of the NPs into the therapeutic realm.


Assuntos
Neoplasias Encefálicas/terapia , DNA/química , Nanopartículas Metálicas/química , Imagem Óptica/métodos , Neoplasias Ovarianas/terapia , Análise Espectral Raman/métodos , Animais , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/cirurgia , Linhagem Celular Tumoral , DNA/metabolismo , Portadores de Fármacos/síntese química , Portadores de Fármacos/farmacocinética , Feminino , Corantes Fluorescentes/química , Engenharia Genética , Humanos , Terapia a Laser/instrumentação , Terapia a Laser/métodos , Limite de Detecção , Terapia com Luz de Baixa Intensidade/instrumentação , Terapia com Luz de Baixa Intensidade/métodos , Nanopartículas Metálicas/administração & dosagem , Camundongos , Imagem Óptica/instrumentação , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/cirurgia , Imagens de Fantasmas , Prata/química , Análise Espectral Raman/instrumentação , Ensaios Antitumorais Modelo de Xenoenxerto
16.
J Drugs Dermatol ; 18(4): s135-137, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-31017752

RESUMO

Individuals with skin of color are a rapidly growing portion of the cosmetic procedures market. There are unique challenges to treating skin conditions in skin of color patients. This article and roundtable discussion focus on the use of energy-based modalities, particularly a 650-microsecond 1064nm laser that delivers energy in a collimated beam. Alone or in combination with other therapies, the 650-microsecond 1064nm laser has been used successfully to treat melasma, acne, postinflammatory hyperpigmentation, pseudofolliculitis barbae, hair removal, acne keloidalis nuchae, and aging skin in skin of color. J Drugs Dermatol. 2019;18(4 Suppl 1):s135-137.


Assuntos
Remoção de Cabelo/instrumentação , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Envelhecimento da Pele/efeitos da radiação , Dermatopatias/terapia , Adulto , Feminino , Remoção de Cabelo/métodos , Humanos , Lasers de Estado Sólido/efeitos adversos , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Pigmentação da Pele/efeitos da radiação , Resultado do Tratamento , Adulto Jovem
17.
Rev. medica electron ; 41(2): 323-332, mar.-abr. 2019. tab
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1004270

RESUMO

RESUMEN Introducción: el acné es una enfermedad multifactorial que afecta en estructura y función a la unidad pilosebácea. Se presenta en los adolescentes y se padece mundialmente. En los casos más severos, puede involucrar al grupo familiar en su esfera afectiva y económica. La terapia láser de baja potencia se ha empleado como opción de procedimiento médico alternativo para el tratamiento de esta enfermedad; por su acción antibacteriana, antiedematosa y estimulante del sistema inmunitario. Objetivo: determinar el comportamiento del acné vulgar en pacientes con terapia láser de baja potencia. Materiales y métodos: se realizó un estudio descriptivo, prospectivo, en pacientes con formas clínicas leves y moderadas de acné vulgar que acudieron a la consulta de Dermatología del Hospital Universitario Comandante "Faustino Pérez Hernández", provincia Matanzas, entre junio del 2015 a junio del 2016. Se estudiaron las variables: edad, sexo, color de la piel, nivel de escolaridad, clasificación del acné, número de lesiones inflamatorias por hemicara, su tamaño, respuesta al tratamiento y grado de satisfacción. Se procesaron en el paquete estadístico SPSS para Windows, versión 16.0. Resultados: la mayor frecuencia de presentación fue de 18-25 años, sexo femenino y raza blanca. Respuesta satisfactoria independiente a su clasificación, con 15 sesiones, dos veces por semana. Conclusiones: el láser de baja potencia mejora y acorta el tiempo de evolución del acné vulgar.


ABSTRACT Introduction: acne is a multifactor disease that affects the structure and function of the pilosebaceous unit. It is a global condition that starts during adolescence. It can involve the family in its affective and economic sphere in the most severe cases. Low-power laser therapy is used as an alternative medical procedure for the treatment of this disease due to its antibacterial, antiedematous and immune-stimulant action. Objective: to determine the behavior of acne vulgar in patients under low potency laser therapy. Materials and methods: a descriptive, prospective study was carried out in patients suffering mild and moderated clinical forms of acne vulgaris who assisted the Dermatology consultation of the University Clinico-surgical Hospital "Faustino Perez Hernandez"¨, Matanzas province, from June 2015 to June 2016. The studied variables were age, sex, race, scholarship, acne classification, number of inflammatory lesions per hemiface, lesson size, answer to treatment and satisfaction level. Data were processed with the SPSS statistical package, 16.0 version for Windows. Results: the highest presentation frequency was in people aged 18-25 years, of the female sex and white race. The answer was satisfactory independently to classification with 15 sessions, twice a week. Conclusion: low potency laser improves and reduces acne vulgaris evolution time.


Assuntos
Humanos , Adolescente , Adulto , Acne Vulgar/diagnóstico , Acne Vulgar/prevenção & controle , Acne Vulgar/radioterapia , Terapia com Luz de Baixa Intensidade/instrumentação , Epidemiologia Descritiva , Estudos Prospectivos
18.
Dermatol Surg ; 45(10): 1253-1259, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-30882500

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of combination therapy with sclerotherapy and dual-wavelength pulsed dye laser (PDL) & Nd:YAG for infantile hemangiomas (IHs). PATIENTS AND METHODS: Fifty-nine patients with IH received treatment with sclerotherapy and dual-wavelength PDL & Nd:YAG treatment at 4-week intervals. Observers assessed the size and color of IH using a size rating scale and color rating scale before and after treatments. RESULTS: The study showed that IH improved significantly after several sessions of treatment. Sclerotherapy reduced the size of IH, whereas dual-wavelength laser lightened the color of IH. No serious adverse effects occurred. CONCLUSION: Combined sclerotherapy and dual-wavelength laser treatment is an effective and safe option for IH.


Assuntos
Hemangioma Capilar/terapia , Lasers de Corante/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Escleroterapia/métodos , Neoplasias Cutâneas/terapia , Grupo com Ancestrais do Continente Asiático , Cor , Terapia Combinada/efeitos adversos , Terapia Combinada/métodos , Feminino , Humanos , Lactente , Lasers de Corante/efeitos adversos , Terapia com Luz de Baixa Intensidade/efeitos adversos , Terapia com Luz de Baixa Intensidade/instrumentação , Masculino , Escleroterapia/efeitos adversos , Pele/irrigação sanguínea , Pele/efeitos da radiação , Resultado do Tratamento
20.
J Cosmet Dermatol ; 18(3): 700-702, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30801957

RESUMO

Pigmentary demarcation lines (PDLs) are physiological abrupt transitions between hyperpigmented and lighter skin, a common and sometimes troubling feature of normal skin. They are seen in a majority of dark-complexioned women and a substantial percentage of light-complexioned ones too. We review this salient finding and approaches to its management.


Assuntos
Transtornos da Pigmentação/diagnóstico , Complicações na Gravidez/diagnóstico , Pigmentação da Pele/fisiologia , Administração Cutânea , Fármacos Dermatológicos/administração & dosagem , Diagnóstico Diferencial , Feminino , Humanos , Lasers , Terapia com Luz de Baixa Intensidade/instrumentação , Terapia com Luz de Baixa Intensidade/métodos , Masculino , Transtornos da Pigmentação/etiologia , Transtornos da Pigmentação/terapia , Gravidez , Complicações na Gravidez/etiologia , Complicações na Gravidez/terapia
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