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1.
Medicine (Baltimore) ; 100(32): e26864, 2021 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-34397897

RESUMO

BACKGROUND: Lung cancer is one of the most common cancers, the symptoms and treatment of which can cause negative emotions like anxiety, depression, and cancer-related fatigue (CRF). Nonpharmacological interventions, serving as alternative therapies, can greatly alleviate CRF in lung cancer patients. Previous meta-analyses have reported nonpharmacological interventions of CRF in lung cancer patients, but the results may be conflicting, and the reporting and methodological qualities remain unknown. Moreover, there is limited evidence to identify efficient and safe non-pharmacological interventions of CRF in lung cancer patients. This study aims to assess the therapeutic efficacy of nonpharmacological interventions of CRF in lung cancer patients through a network meta-analysis. METHODS: Relevant literatures reporting non-pharmacological interventions of CRF in lung cancer patients published before June 2021 will be searched in online databases, including Wanfang, VP Information Chinese Journal Service Platform, China National Knowledge Infrastructure, Chinese BioMedicine Literature Database, PubMed, Embase, Cochrane, and Web of science. Two reviewers will be independently responsible for study selection, quality appraisal, and data extraction. Data analysis will be performed using the STATA14.0 and GEMTC 0.14.3 software. RESULTS: This meta-analysis will provide additional and stronger evidences for nonpharmacological interventions of CRF in lung cancer patients. Our findings will be conductive to make therapeutic decisions by clinicians. CONCLUSION: This study will provide a reliable evidence-based basis for non-pharmacological interventions of CRF in lung cancer patients. ETHICS AND DISSEMINATION: Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms. This review would be disseminated in a peer-reviewed journal or conference presentations. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/QRY42.


Assuntos
Terapias Complementares/métodos , Fadiga , Neoplasias Pulmonares , Qualidade de Vida , Prática Clínica Baseada em Evidências , Fadiga/etiologia , Fadiga/terapia , Humanos , Neoplasias Pulmonares/fisiopatologia , Neoplasias Pulmonares/psicologia , Neoplasias Pulmonares/terapia , Metanálise em Rede , Projetos de Pesquisa
2.
Medicine (Baltimore) ; 100(34): e27005, 2021 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-34449470

RESUMO

BACKGROUND: Knee osteoarthritis (KOA) is a common chronic joint disease with serious health economic burden. More and more randomized controlled trials have indicated that traditional Chinese non-pharmacological therapy, including acupuncture, Tai Chi, Tuina, etc can significantly improve pain and physical function of patients with KOA. However, the effects of traditional Chinese non-pharmacological therapy for KOA remain controversial. Most previous systematic reviews did not focus on the effects of traditional Chinese non-pharmacological therapy for KOA as a whole. In Chinese community hospital, however, acupuncture, Tuina, and Tai Chi are usually in the management of KOA as whole-body treatment. METHODS: The electronic databases (PubMed, Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, China Knowledge Resource Integrated Database, and Wanfang Data) will be searched. The search will include all documents from their inception to December 2021. Two reviewers independently extracted the data and assessed the risk of bias by the Cochrane Risk of Bias Tool for randomized controlled trials. The meta-analysis will be conducted with a random or fixed effect model to calculate the standardized mean difference and 95% confidence intervals based on different heterogeneity using the Review Manager Version 5.3 software. The heterogeneity will be examined by Higgins I2 statistic. The subgroup analysis will be conducted based on different types of traditional Chinese non-pharmacological therapy and different outcomes. Quality of evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation. RESULTS: The current systematic review and meta-analysis will be conducted to investigate the effects of traditional Chinese non-pharmacological therapy in the management of KOA. The main outcomes will include pain and disability. The secondary outcomes will include quality of life and adverse events. CONCLUSION: To provide evidence for evidence-based medicine and clinical researchers to choose more effective traditional Chinese non-pharmacological therapy for KOA. INPLASY REGISTRATION NUMBER: INPLASY202170098.


Assuntos
Terapias Complementares/métodos , Medicina Tradicional Chinesa/métodos , Osteoartrite do Joelho/terapia , Terapias Complementares/efeitos adversos , Medicina Tradicional Chinesa/efeitos adversos , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa
3.
Anticancer Res ; 41(7): 3233-3246, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34230117

RESUMO

BACKGROUND/AIM: Upper limb breast cancer-related lymphedema (BCRL) is a chronic and severe condition affecting a significant percentage of breast cancer survivors. Even though its physiopathology is well-known, there is no worldwide consensus on BCRL evaluation and a gold-standard treatment. This narrative review aims at providing a brief descriptive overview with regard to BCRL treatment modalities. MATERIALS AND METHODS: We conducted a literature search within the PubMed database, and 33 articles out of 56 were selected, including reviews, systematic reviews, and meta-analyses aiming find the most updated evidence regarding BCRL treatment modalities. RESULTS: Physical exercise (aerobic exercise, resistance exercise, aquatic therapy), bandages, and intermittent pneumatic compression were shown to be most effective in BCRL patients, in terms of swelling reduction in the acute-intensive phase. Furthermore, physical exercise was beneficial also as a maintenance tool. Manual lymphatic drainage demonstrated efficacy in preventing secondary lymphedema if applied immediately after breast cancer surgery or in early phases of BCRL or as a maintenance tool. Complementary procedures such as acupuncture, reflexology, yoga and photo-biomodulation therapy did not show conclusive results in BCRL treatment. Surgery was shown effective in managing symptoms (liposuction), preventing (lymphaticovenular anastomosis) and treating BCRL (vascularized lymph node transfer). CONCLUSION: BCRL is still a challenging condition either for breast cancer survivors and clinicians, deeply impacting patient functioning and quality of life. Due to the lack of globally accepted criteria in evaluating BCRL, to date a gold standard treatment for this widespread issue is still needed.


Assuntos
Linfedema Relacionado a Câncer de Mama/terapia , Neoplasias da Mama/cirurgia , Linfedema Relacionado a Câncer de Mama/fisiopatologia , Neoplasias da Mama/fisiopatologia , Terapias Complementares/métodos , Exercício Físico/fisiologia , Feminino , Humanos , Sobreviventes
4.
Medicine (Baltimore) ; 100(25): e26397, 2021 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-34160423

RESUMO

BACKGROUND: Dementia is causing a huge medical and socioeconomic burden. Along with strategies to delay cognitive decline in dementia, behavioral and psychological symptoms of dementia (BPSD) are major contributing factor to the burden of dementia, and have been an important clinical issue for successful management of dementia. However, pharmacological strategies such as antipsychotics raise concerns in terms of risk-to-benefit ratio in managing BPSD. Therefore, there is a need for an effective and safe alternative in BPSD management. From this point of view, various complementary and alternative medicines (CAMs) are attracting attention in BPSD management. Therefore, the overview will make it possible to evaluate the feasibility of using CAM as a potential treatment strategy for BPSD in terms of evidence-based medicine. METHODS AND ANALYSIS: Comprehensive searching will be performed in 13 bibliographic databases from their inception dates to November 2021. Systematic reviews and/or meta-analyses that examined the effectiveness and safety of CAM modalities including herbal medicine, acupuncture, acupressure, aromatherapy, meditation, and relaxation on BPSD, will be included. The methodological quality of included reviews will be assessed by using the A MeaSurement Tool to Assess systematic Reviews-2. Two independent researchers will conduct study search, study selection, data extraction, and quality assessment processes. RESULTS: The results of overview will be disseminated by the publication of a manuscript in a peer-reviewed journal or presentation at a relevant conference. CONCLUSION: The findings of this overview will help to solve the major public health problem related to dementia, and will provide patients with dementia, their caregivers, clinicians, and health policy makers credible evidence in mitigating the burden of dementia. ETHICS AND DISSEMINATION: As this protocol is for an overview of systematic reviews and meta-analyses, ethical approval is not required. PROTOCOL REGISTRATION NUMBER: Open Science Framework registry (https://osf.io/g5f3m).


Assuntos
Terapias Complementares/métodos , Demência/terapia , Terapias Complementares/efeitos adversos , Demência/diagnóstico , Demência/epidemiologia , Demência/psicologia , Estudos de Viabilidade , Carga Global da Doença , Humanos , Metanálise como Assunto , Revisões Sistemáticas como Assunto , Resultado do Tratamento
5.
Expert Rev Clin Pharmacol ; 14(7): 865-888, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33993811

RESUMO

Introduction: Due to the high cost, low effectiveness, and adverse effects plus the life-long nature of inflammatory bowel disease (IBD), and misconception on safety, efficacy, and cost-effectiveness of complementary and alternative medicine (CAM), the market demand for CAM has risen over the past decades. A critical review of patients' and physicians' attitudes, market drivers, economic aspects, regulatory roles, and regional distribution is lacking.Areas covered: Through relevant databases, the existing English language literature concerning the association of CAM use with IBD was collected over the past two decades. Data was then analyzed, comprehensively summarized in tables/figures, and justified concerning administrative, organizational, regional, economic, and regulatory perspectives.Expert opinion: Although CAM utilization is more prevalent among younger, female, and high-educated IBD patients, issues concerning weak study designs, limited-time period/regional distribution of recent surveys, and lack of economic evaluations on CAM make it entirely unfeasible to draw a firm conclusion. Regulators are lagging in meeting the dire need of IBD patients, especially the elderly. Lack of legislation regarding registration, sales monitoring, licensing, insurance coverage, efficacy/safety assessments, post-marketing surveillance, quality assurance, and reference pricing alongside the limited support for CAM research are the main matters that should be urgently addressed.


Assuntos
Terapias Complementares/métodos , Doenças Inflamatórias Intestinais/terapia , Fatores Etários , Terapias Complementares/economia , Terapias Complementares/legislação & jurisprudência , Análise Custo-Benefício , Humanos , Fatores Sexuais
6.
World Neurosurg ; 151: e682-e692, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33940275

RESUMO

INTRODUCTION: Complementary and alternative medicine (CAM) are highly used among those diagnosed with glioma. Further research is warranted, however, as it remains important to clearly delineate CAM practices that are unproven, disproven, or promising for future research and implementation. METHODS: A systematic review was conducted to identify all articles that investigated the effect of any CAM therapy on survival of patients with newly diagnosed or recurrent glioma. RESULTS: Eighteen papers and 4 abstracts pertaining to the effects of ketogenic diet (4), antioxidants (3), hyperbaric oxygen (4), cannabinoids (2), carbogen and nicotinamide (3), mistletoe extract (2), hypocupremia and penicillamine (1), and overall CAM use (3) on overall and progression-free survival in patients with low- and high-grade glioma were identified (Levels of Evidence I-IV). Ketogenic diets, hyperbaric oxygen therapy, and cannabinoids appear to be safe and well tolerated by patients; preliminary studies demonstrate tumor response and increased progression-free survival and overall survival when combined with standard of care therapies. Antioxidant usage exhibit mixed results perhaps associated with glioma grade with greater effect on low-grade gliomas; vitamin D intake was associated with prolonged survival. Conversely, carbogen breathing and hypocupremia were found to have no effect on the survival of patients with glioma, with associated significant toxicity. Most modalities under the CAM umbrella have not been appropriately studied and require further investigation. CONCLUSIONS: Despite widespread use, Level I or II evidence for CAM for the treatment of glioma is lacking, representing future research directions to optimally counsel and treat glioma patients.


Assuntos
Neoplasias Encefálicas/terapia , Terapias Complementares/métodos , Glioma/terapia , Terapias Complementares/efeitos adversos , Humanos , Resultado do Tratamento
7.
Front Immunol ; 12: 637553, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34054806

RESUMO

Plants have been extensively studied since ancient times and numerous important chemical constituents with tremendous therapeutic potential are identified. Attacks of microorganisms including viruses and bacteria can be counteracted with an efficient immune system and therefore, stimulation of body's defense mechanism against infections has been proven to be an effective approach. Polysaccharides, terpenoids, flavonoids, alkaloids, glycosides, and lactones are the important phytochemicals, reported to be primarily responsible for immunomodulation activity of the plants. These phytochemicals may act as lead molecules for the development of safe and effective immunomodulators as potential remedies for the prevention and cure of viral diseases. Natural products are known to primarily modulate the immune system in nonspecific ways. A number of plant-based principles have been identified and isolated with potential immunomodulation activity which justify their use in traditional folklore medicine and can form the basis of further specified research. The aim of the current review is to describe and highlight the immunomodulation potential of certain plants along with their bioactive chemical constituents. Relevant literatures of recent years were searched from commonly employed scientific databases on the basis of their ethnopharmacological use. Most of the plants displaying considerable immunomodulation activity are summarized along with their possible mechanisms. These discussions shall hopefully elicit the attention of researchers and encourage further studies on these plant-based immunomodulation products as potential therapy for the management of infectious diseases, including viral ones such as COVID-19.


Assuntos
Produtos Biológicos/uso terapêutico , COVID-19/tratamento farmacológico , Terapias Complementares/métodos , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , SARS-CoV-2/fisiologia , Viroses/tratamento farmacológico , Animais , Humanos , Imunomodulação , Plantas Medicinais , Terpenos/uso terapêutico
8.
J Evid Based Integr Med ; 26: 2515690X211020685, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34057365

RESUMO

The retrospective cohort study aimed to evaluate the clinical outcomes of Ayurveda treatment exposure as an add-on to conventional care in early stage COVID-19 patients admitted at Samaras COVID care center, Ahmedabad, India. Conventional care included Vitamin-c, Azithromycin, and Paracetamol. Ayurveda formulations used as add-on were Dashamula and Pathyadi decoctions along with Trikatu powder, Sanshamani tablet, AYUSH-64 tablet AND Yastimadhu Ghana tablet for oral administration. Considering Add-on Ayurveda medicines as exposure of interest, patients who received Add-on Ayurveda medicines at least for 7 days were included in the exposed group while those who received only conventional care in unexposed group. Data was collected through record review and telephonic interviews. The outcomes of interest were the development of symptoms, duration of symptomatic phase in those progressing to symptomatic stage and mortality. Total 762 participants were included-[541 (71%) in the exposed group and 221 (29%) in the unexposed. Progression to symptomatic phase did not differ significantly between groups [27.6% in exposed, 24.6% in unexposed, adjusted RR 0.85; 95% CI 0.6-1.2]. The total duration of symptomatic phase among those progressing to the symptomatic stage was significantly decreased in the exposed group (x¯ = 3.66 ± 1.55 days in exposed (n = 133); x¯ = 5.34 ± 3.35 days in unexposed (n = 61), p < 0.001). No mortality was observed in either of the groups. Ayurveda Treatment as adjunctive to conventional care reduced the duration of symptomatic phase in early stage COVID-19 as compared to standalone conventional care. Add-on Ayurveda treatment has promising potential for management of early stage COVID-19.


Assuntos
Acetaminofen/uso terapêutico , COVID-19 , Medicina Ayurvédica/métodos , Extratos Vegetais/uso terapêutico , Preparações de Plantas/uso terapêutico , Antipiréticos/uso terapêutico , Antivirais/uso terapêutico , COVID-19/diagnóstico , COVID-19/tratamento farmacológico , COVID-19/epidemiologia , Terapias Complementares/métodos , Quimioterapia Combinada/métodos , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Gravidade do Paciente , Estudos Retrospectivos , SARS-CoV-2/isolamento & purificação , Resultado do Tratamento
9.
Medicine (Baltimore) ; 100(18): e25769, 2021 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-33950966

RESUMO

BACKGROUND: Scapulohumeral periarthritis is a disease with high incidence and great pain. The current western treatments with many side effects, poor efficacy cannot fundamentally solve the problem. Complementary and alternative therapies have played an excellent role in the treatment of scapulohumeral periarthritis. However, it is not clear which complementary and alternative therapy is more effective. Therefore, we propose a protocol to compare the efficacy and safety of various complementary and alternative therapies through network meta-analysis (NMA) to provide choice guidance for the therapy. METHODS: A comprehensive search will be conducted for randomized controlled trials of complementary and alternative therapy for scapulohumeral periarthritis as well as ongoing trials. The time limit is from the establishment of the database until January 2021. Literature and data extraction were completed independently by two researchers. Through pairwise comparison and meta-analysis of Bayesian NMA, all the evidences are evaluated comprehensively. STATA16.0 and WinBUGS1.4.3 software will be used for data processing and analysis, and recommendation evaluation will be used to develop and assess grades to classify the quality of NMA evidence. RESULTS: Through the analysis, we will obtain the ranking of the efficacy and safety of different complementary and alternative therapies in the treatment of scapulohumeral periarthritis, in order to provide reference for clinical selection of treatment methods. CONCLUSION: Complementary and alternative therapies of scapulohumeral periarthritis plays a positive role in improving the symptoms of scapulohumeral periarthritis. This study can provide evidence support for clinicians and patients.International Platform of Registered Systematic Review and Meta-Analysis Protocols registration number: INPLASY202140044.


Assuntos
Terapias Complementares/métodos , Periartrite/terapia , Dor de Ombro/terapia , Teorema de Bayes , Doença Crônica/terapia , Terapias Complementares/efeitos adversos , Humanos , Metanálise como Assunto , Medição da Dor , Periartrite/complicações , Periartrite/imunologia , Periartrite/patologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Articulação do Ombro/imunologia , Articulação do Ombro/patologia , Dor de Ombro/diagnóstico , Dor de Ombro/etiologia , Resultado do Tratamento
10.
Curr Opin Ophthalmol ; 32(4): 348-361, 2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-34010229

RESUMO

PURPOSE OF REVIEW: Dry eye disease (DED) is a multifactorial disease affecting approximately 5-50% of individuals in various populations. Contributors to DED include, but are not limited to, lacrimal gland hypofunction, meibomian gland dysfunction (MGD), ocular surface inflammation, and corneal nerve dysfunction. Current DED treatments target some facets of the disease, such as ocular surface inflammation, but not all individuals experience adequate symptom relief. As such, this review focuses on alternative and adjunct approaches that are being explored to target underlying contributors to DED. RECENT FINDINGS: Neuromodulation, stem cell treatments, and oral royal jelly have all been studied in individuals with DED and lacrimal gland hypofunction, with promising results. In individuals with MGD, devices that provide eyelid warming or intense pulsed light therapy may reduce DED symptoms and signs, as may topical Manuka honey. For those with ocular surface inflammation, naturally derived anti-inflammatory agents may be helpful, with the compound trehalose being farthest along in the process of investigation. Nerve growth factor, blood-derived products, corneal neurotization, and to a lesser degree, fatty acids have been studied in individuals with DED and neurotrophic keratitis (i.e. corneal nerve hyposensitivity). Various adjuvant therapies have been investigated in individuals with DED with neuropathic pain (i.e. corneal nerve hypersensitivity) including nerve blocks, neurostimulation, botulinum toxin, and acupuncture, although study numbers and design are generally weaker than for the other DED sub-types. SUMMARY: Several alternatives and adjunct DED therapies are being investigated that target various aspects of disease. For many, more robust studies are required to assess their sustainability and applicability.


Assuntos
Terapias Complementares/métodos , Síndromes do Olho Seco/terapia , Aparelho Lacrimal/diagnóstico por imagem , Síndromes do Olho Seco/diagnóstico , Humanos
11.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48186

RESUMO

Este mapa de evidências científicas apresenta uma síntese gráfica de estudos clínicos sobre a aplicação da Medicina Tradicional Chinesa para desfechos de obesidade e sobrepeso, e tabagismo. A partir de uma ampla busca bibliográfica 03 ensaios clínicos randomizados (ECR) foram incluídos no mapa e categorizados por tipo de intervenção e por desfechos. Os estudos avaliaram o efeito de 03 tipos de intervenção: Tai chi, Qigong e Terapias combinadas. Principais Achados: Os estudos foram realizados entre 2007 e 2015 nos seguintes países: Hong Kong, Estados Unidos da América e França. Não foram encontradas revisões sistemáticas sobre as intervenções. Também não foram encontrados ensaios clínicos randomizados (ECR) para os desfechos de tabagismo. Embora existam alguns resultados favoráveis à prática de tai Tai chi, é pequena a evidência de eficácia e segurança da prática de Medicina Tradicional Chinesa no tratamento da obesidade em adultos e idosos. A avaliação metodológica dos ECR mostrou alto risco de viés de alocação em um estudo, risco de viés de alocação incerto e alto risco de viés de atrito em outro estudo, e risco de viés incerto para randomização e alocação no terceiro estudo.


Assuntos
Medicina Tradicional Chinesa/métodos , Obesidade/terapia , Tai Ji/métodos , Terapias Complementares/métodos , Tabagismo/terapia
12.
Phys Med Rehabil Clin N Am ; 32(2): 393-403, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33814064

RESUMO

Complementary and integrative health (CIH) modalities have therapeutic value in the multidisciplinary rehabilitation of chronic pain patients. Evidence of such has been seen with the Whole Health Model at the (Veterans Affairs) VA Healthcare system. CIH therapies, including yoga, tai chi, mindfulness meditation, hypnosis, self-massage, and acupressure, are significantly effective for managing chronic pain with little to no negative effects, and can be easily incorporated into telemedicine care with great potential benefit. The future of wellness in telemedicine is evolving with great potential, and needs further attention to addressing barriers of care.


Assuntos
Dor Crônica/terapia , Terapias Complementares/métodos , Acesso aos Serviços de Saúde , Medicina Integrativa/métodos , Telemedicina/métodos , Serviços de Saúde para Veteranos Militares , COVID-19/epidemiologia , Humanos , Pandemias , SARS-CoV-2 , Estados Unidos/epidemiologia
14.
Medicine (Baltimore) ; 100(17): e25686, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-33907142

RESUMO

BACKGROUND: Development dysplasia of the hip (DDH) is a common childhood orthopedic disease in clinic. The cause of DDH is not yet clear. If DDH is not treated promptly or correctly, it will seriously affect the life quality of the child. At present, surgery is the main means of treating older DDH, but it is easy to appear development dysplasia of the hip after surgery, and the joint movement is limited after surgery. For modern medicine, it has not many treatments to solve this problem. As one of the commonly used treatment methods, but the effect of routine functional exercise is not ideal. Traditional Chinese medicine fumigation and washing belongs to the category of Chinese medicine external treatment, which can directly act on the focus. It has the functions of relaxing muscles and tendons and removing obstruction from meridians, activating blood to eliminate stagnation. It has achieved good effects in relieving joint disorders, but it is lack of the high-quality evidence support, so there is controversy about the clinical application of traditional Chinese medicine fumigation and washing. This study will conduct a systematic review to compare the application effect and safety of traditional Chinese medicine fumigation and washing as a complementary and alternative therapy and traditional rehabilitation training in the treatment of postoperative joint function recovery after development dysplasia of the hip in children. The research results will provide evidence-based medical evidence to support the choice of treatment for the disease. METHODS: Using computer to retrieve PubMed, ScienceDirect, Web of Science, EMBase, Cochrane Library, WANFANG Database, CNKI, and VIP Database, CBM, and using the method of combining mesh words with item words to retrieve the Chinese and English databases, to retrieve the randomized controlled study on the application of traditional Chinese medicine fumigation and washing on the recovery of joint function after development dysplasia of the hip in children. The retrieval time is from January 1990 to January 2021. Two researchers screen and evaluate the quality of the retrieved literatures according to the inclusion and exclusion criteria. In the event of a disagreement, a third researcher will join the discussion to resolve the disagreement. Using Revman 5.3 software to conduct meta-analysis. RESULTS: This study will compare the application effect and safety of traditional Chinese medicine fumigation and washing as a complementary and alternative therapy and traditional rehabilitation training in the treatment of postoperative joint function recovery after development dysplasia of the hip in children. CONCLUSION: The results of this study will be published in an internationally influential academic journal to provide evidence-based medical evidence for the selection of supplement and alternative therapies on the recovery of joint function after development dysplasia of the hip in children. ETHICS AND DISSEMINATION: This study does not involve specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of this study. OSF REGISTRATION: DOI 10.17605/OSF.IO/RUHK5.


Assuntos
Artroscopia/reabilitação , Terapias Complementares/métodos , Fumigação/métodos , Luxação Congênita de Quadril/reabilitação , Medicina Tradicional Chinesa/métodos , Criança , Pré-Escolar , Feminino , Luxação Congênita de Quadril/fisiopatologia , Luxação Congênita de Quadril/cirurgia , Articulação do Quadril/fisiopatologia , Articulação do Quadril/cirurgia , Humanos , Masculino , Metanálise como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Amplitude de Movimento Articular , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
15.
Medicine (Baltimore) ; 100(17): e25747, 2021 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-33907170

RESUMO

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors in the human digestive system, which seriously affects people's quality of life. As an effective treatment for GC, traditional Chinese medicine can effectively alleviate patients' clinical symptoms, improve the quality of life, and delay the life cycle. A large number of clinical studies have shown that Banxia Xiexin Decoction has shown a good effect in the treatment of GC. It has achieved good curative effect whether it is used alone or combined with radiotherapy and chemotherapy, which may play a more significant role in the treatment of GC. However, there is still no evidence of evidence-based medicine. Therefore, this study aims to systematically evaluate the efficacy and safety of Banxia Xiexin Decoction as a complementary treatment for GC. METHODS: Two researchers will search the following databases: PubMed, Web of Science, MEDLINE, the Cochrane Library, Embase, China National Knowledge Infrastructure, the Chongqing VIP Chinese Science and Technology Periodical Database, Wanfang Database, and China Biomedical Database. In addition, the Chinese Clinical Trial Register, Chinese Clinical Trial Register, conference papers, and other relevant literature will be searched manually. The retrieval time of these databases is from the establishment of the database to March 2021. The main outcome indicators of this study are the effective rate of treatment and the traditional Chinese medicine syndrome score. According to the inclusion and exclusion criteria of the literature, the data were screened and extracted. The literature quality was evaluated by the bias risk assessment tool of randomized controlled trials recommended by Cochrane Handbook, and meta-analysis was conducted RevMan 5.3 software. The Grading of Recommendations Assessment, Development, and Evaluation will be used to evaluate the quality of evidence. RESULTS: This study will comprehensively review the existing evidence of Banxia Xiexin Decoction as a complementary in the treatment of GC. CONCLUSION: The conclusion of this study will provide a basis for judging whether Banxia Xiexin Decoction is an effective and safe intervention for GC patients. UNIQUE INPLASY NUMBER: INPLASY202140060.


Assuntos
Terapias Complementares/métodos , Medicamentos de Ervas Chinesas/farmacologia , Neoplasias Gástricas/terapia , Fármacos Gastrointestinais/farmacologia , Humanos , Medicina Tradicional Chinesa/métodos , Metanálise como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
16.
Medicine (Baltimore) ; 100(16): e25544, 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33879702

RESUMO

BACKGROUND: Tension-type headache (TTH) is the most common form of primary headache with high prevalence, which affects the quantity of life seriously. The pharmacological treatment of TTH is not the most effective. Meanwhile, complementary therapies and alternative therapies play an essential role in the treatment of TTH, and there is an absence of comparison between various interventions. Therefore, we propose the network meta-analysis protocol to compare the efficacy and safety of various complementary therapies and alternative therapies for TTH. METHODS: From the beginning to February 2021, we will search the database to collect randomized controlled trials of complementary and alternative therapies for TTH. Two researchers will be responsible for screening retrieve documents, extracting data. The risk of bias will be assessed based on the Cochrane bias risk tool. We will use STATA16.0 and WinBUGS1.4.3 for paired meta-analysis and Bayesian network meta-analysis. The quality of evidence will be assessed using the grading of recommendations assessment development and evaluation. RESULTS: This study will compare and rank the efficacy and safety of various complementary and alternative treatments for TTH. CONCLUSIONS: This study will provide more extensive evidence for the complementary and alternative therapies of TTH. We expect to assist clinicians and patients in choosing the optimum treatment. PROTOCOL REGISTRATION NUMBER: INPLASY202130088.


Assuntos
Terapias Complementares/métodos , Cefaleia do Tipo Tensional/terapia , Teorema de Bayes , Humanos , Metanálise em Rede , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Revisões Sistemáticas como Assunto , Resultado do Tratamento
17.
Int J Mol Sci ; 22(8)2021 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-33919895

RESUMO

The mechanisms underlying multifactorial diseases are always complex and challenging. Neurodegenerative disorders (NDs) are common around the globe, posing a critical healthcare issue and financial burden to the country. However, integrative evidence implies some common shared mechanisms and pathways in NDs, which include mitochondrial dysfunction, neuroinflammation, oxidative stress, intracellular calcium overload, protein aggregates, oxidative stress (OS), and neuronal destruction in specific regions of the brain, owing to multifaceted pathologies. The co-existence of these multiple pathways often limits the advantages of available therapies. The nutraceutical-based approach has opened the doors to target these common multifaceted pathways in a slow and more physiological manner to starve the NDs. Peer-reviewed articles were searched via MEDLINE and PubMed published to date for in-depth research and database collection. Considered to be complementary therapy with current clinical management and common drug therapy, the intake of nutraceuticals is considered safe to target multiple mechanisms of action in NDs. The current review summarizes the popular nutraceuticals showing different effects (anti-inflammatory, antioxidant, neuro-protectant, mitochondrial homeostasis, neurogenesis promotion, and autophagy regulation) on vital molecular mechanisms involved in NDs, which can be considered as complementary therapy to first-line treatment. Moreover, owing to its natural source, lower toxicity, therapeutic interventions, biocompatibility, potential nutritional effects, and presence of various anti-oxidative and neuroprotective constituents, the nutraceuticals serve as an attractive option to tackle NDs.


Assuntos
Antioxidantes/uso terapêutico , Suplementos Nutricionais , Doenças Neurodegenerativas/tratamento farmacológico , Inanição/tratamento farmacológico , Encéfalo/efeitos dos fármacos , Terapias Complementares/métodos , Humanos , Doenças Neurodegenerativas/patologia , Neurônios/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Inanição/patologia
18.
Enferm. glob ; 20(62): 614-652, abr. 2021. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-202244

RESUMO

OBJETIVO: Identificar los efectos de Chamomilla recutita (CR) a través de la literatura nacional e internacional. MÉTODO: Optamos por una revisión sistemática que incluía el análisis riguroso de los artículos, siendo extremadamente confiable y de gran importancia para los investigadores. Los artículos analizados se estudiaron cuidadosamente, de modo que hubo una recopilación de datos sobre los posibles efectos beneficiosos de la planta en cuestión, además del intento de determinar el método y la cantidad necesaria para que se pudiera obtener una aplicación terapéutica correcta en los portadores de este efecto secundario. Al final de la selección de estudios definidos por los criterios establecidos, se aplicaron nuevos instrumentos para validarlos, donde se llegó a una serie de estudios que fueron de máxima relevancia para la presente revisión. RESULTADOS: Con el análisis de los estudios, se encontró CR en forma de enjuagues bucales, pomadas, tinturas e infusiones, todos con diferentes formas de concentración, preparación y uso. Con los análisis realizados, se encontró que la CR tiene un efecto terapéutico potencial en la práctica clínica con pacientes oncológicos y hematológicos, ya que proporciona amplios beneficios para esta población. CONCLUSIÓN: Las formas de usar la CR demostraron ser efectivas, sin embargo, el método de enjuague e infusión fueron los estudios que más demostraron efectos beneficiosos para sus pacientes, a pesar de que todos mostraron efectividad. Se sugiere que los estudios futuros incluyan este método en la práctica clínica de los proveedores de servicios, para beneficiar a sus usuarios


OBJECTIVE: To identify through national and international literature the effects of Chamomilla recutita (CR). METHOD: A systematic review was chosen which included rigorous analysis of articles, being extremely reliable and of great importance for researchers. The articles analyzed were carefully studied in order to collect data on the potential beneficial effects of the plant in question, in addition to the attempt to verify which method and quantity was necessary to obtain a correct therapeutic application in those with this side effect. At the end of the selection of studies defined by the established criteria, new instruments were applied to validate them, where a quantity of researches that were of entire relevance for this review was reached. RESULTS: With the analysis of the studies, CR was found in the form of mouth rinses, ointments, tinctures and infusions, all with different forms of concentration, preparation and use. The analysis showed that CR presents a potential therapeutic effect in clinical practice with oncologic and hematologic patients, because it provides ample benefits to this population. CONCLUSION: The ways of using CR showed to be effective, however, the method of rinsing and infusion were the studies that most demonstrate beneficial effects to their patients, although all showed effectiveness. It is suggested future studies to insert this method in the clinical practice of service providers, in order to benefit its users


OBJETIVO: Identificar através da literatura nacional e internacional os efeitos da Chamomilla recutita (CR). MÉTODO: Optou-se por uma revisão sistemática que incluiu a análise rigorosa de artigos, sendo extremamente confiável e de grande importância para pesquisadores. Os artigos analisados foram criteriosamente estudados, para que houvesse uma coleta de dados sobre os potenciais efeitos benéficos da planta em questão, além da tentativa de constatar qual o método e a quantidade necessária para que se pudesse obter uma correta aplicação terapêutica nos portadores deste efeito colateral. Ao final da seleção dos estudos definidos pelos critérios estabelecidos, aplicou-se novos instrumentos para validação deles, onde se chegou a uma quantidade de pesquisas que eram de inteira relevância para a presente revisão. RESULTADOS: Com a análise dos estudos, foi encontrado a CR em forma de enxaguatórios bucais, pomadas, tinturas e infusões, todas com diferentes formas de concentração, preparação e uso. Constatou-se com as análises realizadas, que a CR apresenta um potencial efeito terapêutico na prática clínica com pacientes oncológicos e hematológicos, pois proporciona amplos benefícios para esta população. CONCLUSÃO: As formas de utilização da CR mostraram-se eficazes, entretanto, o método de enxaguante e infusão foram os estudos que mais demonstram efeitos benéficos aos seus pacientes, apesar de todos demonstrarem eficácia. Sugere-se estudos futuros para que haja inserção deste método na prática clínica dos prestadores de serviços, a fim de beneficiar seus usuários


Assuntos
Humanos , Matricaria , Estomatite/terapia , Neoplasias/complicações , Terapias Complementares/métodos , Estomatite/complicações , Neoplasias/epidemiologia , Terapias Complementares/estatística & dados numéricos , Anti-Inflamatórios/metabolismo
19.
BMC Complement Med Ther ; 21(1): 85, 2021 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-33685422

RESUMO

BACKGROUND: Many parents choose support such as Complementary and Alternative Medicine (CAM) for themselves and their children who have cancer. The aim of this paper is to describe, how parents who have children with cancer communicated with conventional health care providers about CAM, and what types and sources of information they would like to receive about CAM when the child was ill. METHOD: This focused ethnography draws from in-depth, semi-structured interviews conducted with 22 families in Norway with 24 adult participants (two couples), including two individuals who had had cancer themselves. Four domains were explored in the data analysis: the use of CAM, advice from laypeople about CAM, communication with conventional health care providers about CAM, and parents' information needs about CAM. RESULTS: Many of the participants had personal experiences with CAM before the child received the cancer diagnosis. The health care providers did not raise the question about CAM in the consultations. However, when the parents raised the question, they were mostly met in a positive way. The participants did not receive any information about CAM at the hospital, which they would have appreciated. Instead, they received recommendations about CAM from laypersons, which were mostly rejected, as the advice was not in line with their health values/philosophy. CONCLUSION: The reason participants did not disclose CAM use is that physicians did not ask them about it. However, positive communication about conventional treatment facilitated fruitful conversations about CAM. The participants wanted information about CAM from authoritative sources, primary from health care providers at the hospital and the Children's Cancer Society. They demand information about risks and benefits when using CAM as well as whether CAM can improve the immune system, fight the cancer, and improve the quality of life of the family. An evidence-based decision aid is warranted to enable health care providers and parents of children with cancer to make well-informed decisions about CAM.


Assuntos
Comunicação , Terapias Complementares/métodos , Neoplasias/terapia , Pais/psicologia , Relações Médico-Paciente , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Comportamento de Busca de Informação , Masculino , Pessoa de Meia-Idade , Pesquisa Qualitativa , Adulto Jovem
20.
BMC Complement Med Ther ; 21(1): 81, 2021 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-33691698

RESUMO

BACKGROUND: Customers' expectations and satisfaction are critical to ensure a more effective role of the community pharmacists in promoting the safe use of Complementary and Alternative Medicine (CAM). The aim of this study is to examine the perceptions and practices of customers buying their CAM products from pharmacies and explore their satisfaction with CAM-related services offered by the community pharmacists in Lebanon. METHODS: A national cross-sectional study was conducted among users of CAM (age > =18 years) who obtained their CAM from community pharmacies in Lebanon (n = 832). Within the proximity of the pharmacy, subjects were invited to complete a multi-component questionnaire. The latter consisted of four sections related to CAM: general beliefs, perception of pharmacists' role, practices, satisfaction with services offered by the pharmacists. In addition, the questionnaire included questions about sociodemographic characteristics of participants. RESULTS: The majority of participants agreed to an active role of the pharmacists' in guiding CAM use, however over half of the participants (61.3%) did not agree that the pharmacist is more knowledgeable in this field than other healthcare providers. As for practices, one in two surveyed customers (47%) did not always give feedback to their pharmacists about the outcomes after using CAM, 20% did not often ask the pharmacists about the safe and effective mode of use of the products and 28.1% did not discuss their medical history. For services offered by the pharmacist, the majority of participants reported receiving good education about the CAM product (87.1%), its side effects (87.1%) and mode of use (93.4%), while significant proportions of participants reported that pharmacists were not asking questions about their medical history before dispensing CAM products (22%) nor were they providing information on CAM-drug interactions (30%). CONCLUSIONS: The results of this study highlighted important gaps between the perceptions of customers and the services they received from the pharmacists about CAM use. These findings could be used by concerned stakeholders, including public health authorities and educational bodies, to develop evidence-based interventions aimed at promoting the role of pharmacists in ensuring a safe and effective CAM use Lebanon.


Assuntos
Terapias Complementares/métodos , Conhecimentos, Atitudes e Prática em Saúde , Satisfação do Paciente , Farmácias , Farmacêuticos , Papel Profissional , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Líbano , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Adulto Jovem
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