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1.
Wiad Lek ; 74(3 cz 1): 487-491, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33813455

RESUMO

OBJECTIVE: The aim: Of the study was to evaluate the early utility changes of the 13C methacetin breath test parameters in patients with NAFLD. PATIENTS AND METHODS: Materials and methods: There were included 50 subjects in the study, among them 35 patients had steatosis and 15 patients had steatohepatitis, including 35 (70.0%) male subjects and 15 (30.0%) female subjects. The control group included 17 apparently healthy volunteers, among them 10 (58.8%) subjects were male and 7 (41.2%) subjects were female. RESULTS: Results: It was determined that metabolism kinetics in case of liver steatosis was significant decreased more than 30% compared to the control group (p = 0.0001) and in case of steatohepatitis that decrease was more than 65% (p = 0.00001) compared with normal values. It resulted in less cumulative dose accumulation in steatosis (p = 0.00001) and steatohepatitis (p = 0.00001). Among the reasons for the decrease in the kinetics of metabolism in steatosis, there were insufficient response of hepatocytes on 10 minutes (<10 dose/h,%) in 40% of cases and reduction of metabolism rate amplitude at 20-40 minutes following methacetin administration. CONCLUSION: Conclusions: The results of 13C-methacetin breath test demonstrate that in patients with NAFLD there is a gradual slowing of metabolism rate in hepatocytes, which leads to a decrease in cumulative dose.


Assuntos
Hepatopatia Gordurosa não Alcoólica , Acetamidas , Testes Respiratórios , Isótopos de Carbono , Feminino , Humanos , Cirrose Hepática , Masculino , Hepatopatia Gordurosa não Alcoólica/diagnóstico
2.
Pol Merkur Lekarski ; 49(289): 23-27, 2021 Feb 24.
Artigo em Polonês | MEDLINE | ID: mdl-33713088

RESUMO

Small intestinal bacterial overgrowth (SIBO) is a frequent cause of chronic abdominal complaints. So far, a lot information has been gathered on its pathogenesis but are still doubts that raise question why its causes chronic diarrhea in some and constipation in other patients. AIM: The aim of the study was to assess the number of endothelial lymphocytes (IELs) in the duodenal and ileum mucosa in patients with SIBO with dominant diarrhea (SIBO-D) and dominant constipation (SIBO-C). MATERIALS AND METHODS: The study was performed in 30 healthy patients (group I) and 40 patients with SIBO and diarrhoea (group II), and in 4o patients with constipation (group III). To diagnose SIBO the lactulose hydrogen breath test (LHBT) was performed. To determine the number of intraepithelial lymphocytes in duodenal and jejunal mucosa the histological assessment was performed using haematoxylin-eosin staining. Moreover, immunochistochemical method was used to assess the number of enterochromatoffin cells (EC, chromogranin A - LK-2H10) in these some parts of the gut. RESULTS: The results of LHBT were similar in group II and III - 75,6±18,1 ppm and 66,9±16,2 ppm(p>0,05). The number of IELs in duodenal mucosa in controls was 14,6±4,1/100 EN, in group II - 28,3±6,8/100 EN (p<0.01), and in group III - 23,0±9,9/100 EN (p<0,05), and similar differences were in jejunal mucosa. The number of EC in both parts of the gut was higher in SIBO compared to controls. Furthermore, in patients with SIBO-D the number of IELs in duodenum, as well as in jejunum, was positively correlated with the number of EC cells ( p<0,05, p=0,056, respectively). CONCLUSIONS: In patients with SIBO, particularly with SIBO-D, increased number of IELs I EC cells may be a cause of diverse abdominal symptoms.


Assuntos
Síndrome da Alça Cega , Linfócitos Intraepiteliais , Síndrome do Intestino Irritável , Síndrome da Alça Cega/complicações , Síndrome da Alça Cega/diagnóstico , Testes Respiratórios , Humanos , Intestino Delgado , Lactulose
3.
Appl Opt ; 60(7): 2093-2099, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33690303

RESUMO

An easy-to-use highly sensitive sensor is reported for trace gas analysis. A near-infrared fiber-coupled external cavity diode laser in combination with a photoacoustic spectroscopy cell and a cavity enhanced absorption spectroscopy cell is used for analysis of trace gases. A software platform for direct absorption and wavelength modulation spectroscopy is developed in order to identify and quantify the molecules and to achieve a higher signal-to-noise ratio. Considering all of these features, the main advantage of our system is to analyze two different samples simultaneously and quickly. Trace gas measurement is assessed, and a detection limit of 1.5 ppb at 6528.76cm-1 for ammonia is demonstrated. Furthermore, the sensor with our software platform can be easily used outside of the laboratory, for example, in hospitals.


Assuntos
Técnicas Biossensoriais , Testes Respiratórios/métodos , Técnicas Fotoacústicas/métodos , Análise Espectral/métodos , Biomarcadores/análise , Monitoramento Ambiental/instrumentação , Sensibilidade e Especificidade , Software
4.
Dtsch Med Wochenschr ; 146(7): 441-445, 2021 04.
Artigo em Alemão | MEDLINE | ID: mdl-33780988

RESUMO

The functional gastrointestinal disorders (FGIDs) have a high prevalence and are associated with high healthcare costs. The diagnosis of these diseases could be difficult and require func-tional tests such as high-resolution manometry (HRM) of the esophagus, anorectal manometry and H2-Breathtests. Due to the COVID-19 Pandemic and the fear of infections there was a marked reduction in the number of performed exams in the last months - nevertheless some exams are necessary, in order to exclude or to diagnose important and dangerous diseases like Achalasia. Goal of this article is to present some new and relevant developments in the field. The HRM of the esophagus is the diagnostic standard for Achalasia, a rare clinical condi-tion associated to dysphagia - new European guidelines suggests a safe strategy in perform-ing the pneumatic dilatation.The intestinal methanogen overgrowth (IMO) is a clinical condition caused by a high production of methane in the small intestine due to overgrowth of Methanobrevibacter smithii, this condition could be in some patients associated with irritable bowel syndrome.


Assuntos
/complicações , Gastroenteropatias/diagnóstico , Archaea/metabolismo , Testes Respiratórios , Acalasia Esofágica/diagnóstico , Esôfago/fisiopatologia , Gastroenteropatias/economia , Gastroenteropatias/epidemiologia , Humanos , Intestino Delgado/microbiologia , Manometria , Metano/biossíntese , Guias de Prática Clínica como Assunto , Reto/fisiopatologia
5.
Zhonghua Nei Ke Za Zhi ; 60(4): 356-361, 2021 Apr 01.
Artigo em Chinês | MEDLINE | ID: mdl-33765706

RESUMO

Objective: To evaluate the diagnostic value of hydrogen sulfide breath test(SBT) for small intestinal bacterial overgrowth (SIBO). Methods: College students were enrolled to complete gastrointestinal symptom scale, food frequency questionnaire, lactulose hydrogen- methane breath test (LHMBT) and SBT. Based on the correlation between hydrogen sulfide(H2S) and hydrogen or methane gas,the receiver operating characteristic (ROC) curve of H2S was drawn and diagnostic criteria of SBT was defined. Results: A total of 300 subjects including 84 males and 216 females with age 17-32 (21.6±2.4) years were enrolled from April 2019 to December 2019 and divided into two groups.Two hundred and three patients reported SIBO discomforts with 99 (48.8%) LHMBT positive, while 38 (39.2%) were LHMBT positive in 97 health controls. Rise of H2S at 90 min was positively related with that of hydrogen (r=0.516, P<0.01), and H2S levels at 90 min were positively correlated with methane (r=0.632, P<0.01). A rise in H2S of ≥25.0 ppb or H2S levels ≥62.5 ppb at 90 min during lactulose breath test was considered positive for SIBO, that sensitivity, specificity and accuracy were 66.4%,79.1% and 73.3% respectively. H2S levels were significantly related to the amount of Vitamin B12 intake (P=0.011). H2S-positive subjects exhibited a constipation-predominant pattern. Conclusion: SBT is consistent with LHMBT, especially in constipation-predominant patients, which may provide a reference to the diagnosis of SIBO.


Assuntos
Infecções Bacterianas , Sulfeto de Hidrogênio , Adolescente , Adulto , Testes Respiratórios , Feminino , Humanos , Intestino Delgado , Lactulose , Masculino , Adulto Jovem
6.
PLoS One ; 16(2): e0246123, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33577565

RESUMO

BACKGROUND: Nasal High Flow (NHF) therapy delivers flows of heated humidified gases up to 60 LPM (litres per minute) via a nasal cannula. Particles of oral/nasal fluid released by patients undergoing NHF therapy may pose a cross-infection risk, which is a potential concern for treating COVID-19 patients. METHODS: Liquid particles within the exhaled breath of healthy participants were measured with two protocols: (1) high speed camera imaging and counting exhaled particles under high magnification (6 participants) and (2) measuring the deposition of a chemical marker (riboflavin-5-monophosphate) at a distance of 100 and 500 mm on filter papers through which air was drawn (10 participants). The filter papers were assayed with HPLC. Breathing conditions tested included quiet (resting) breathing and vigorous breathing (which here means nasal snorting, voluntary coughing and voluntary sneezing). Unsupported (natural) breathing and NHF at 30 and 60 LPM were compared. RESULTS: Imaging: During quiet breathing, no particles were recorded with unsupported breathing or 30 LPM NHF (detection limit for single particles 33 µm). Particles were detected from 2 of 6 participants at 60 LPM quiet breathing at approximately 10% of the rate caused by unsupported vigorous breathing. Unsupported vigorous breathing released the greatest numbers of particles. Vigorous breathing with NHF at 60 LPM, released half the number of particles compared to vigorous breathing without NHF.Chemical marker tests: No oral/nasal fluid was detected in quiet breathing without NHF (detection limit 0.28 µL/m3). In quiet breathing with NHF at 60 LPM, small quantities were detected in 4 out of 29 quiet breathing tests, not exceeding 17 µL/m3. Vigorous breathing released 200-1000 times more fluid than the quiet breathing with NHF. The quantities detected in vigorous breathing were similar whether using NHF or not. CONCLUSION: During quiet breathing, 60 LPM NHF therapy may cause oral/nasal fluid to be released as particles, at levels of tens of µL per cubic metre of air. Vigorous breathing (snort, cough or sneeze) releases 200 to 1000 times more oral/nasal fluid than quiet breathing (p < 0.001 with both imaging and chemical marker methods). During vigorous breathing, 60 LPM NHF therapy caused no statistically significant difference in the quantity of oral/nasal fluid released compared to unsupported breathing. NHF use does not increase the risk of dispersing infectious aerosols above the risk of unsupported vigorous breathing. Standard infection prevention and control measures should apply when dealing with a patient who has an acute respiratory infection, independent of which, if any, respiratory support is being used. CLINICAL TRIAL REGISTRATION: ACTRN12614000924651.


Assuntos
Expiração , Oxigenoterapia/efeitos adversos , Oxigenoterapia/métodos , Adulto , Testes Respiratórios/métodos , Cânula , Feminino , Humanos , Masculino , Microscopia de Vídeo , Nariz/química , Respiração , Taxa Respiratória
7.
Expert Rev Mol Diagn ; 21(1): 31-42, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33523770

RESUMO

Introduction: The unprecedented outbreaks of corona virus disease of 2019 (COVID-19) have highlighted the necessity of readily available, reliable, precise, and faster techniques for its detection. Nasopharyngeal swab has been the gold standard for the diagnosis of COVID-19. However, it is not an ideal screening procedure for massive screening as it implicates the patient's stay in the hospital or at home until diagnosis, thus causing crowding of the specimen at the diagnostic centers. Present study deal with the exploration of potential application of different body fluids using certain highly objective techniques (Optical and e-Nose) for faster detection of molecular markers thereby diagnosing viral infections.Areas covered: This report presents an evaluation of different body fluids, and their advantages for the rapid detection of COVID-19, coupled with highly sensitive optical techniques for the detection of molecular biomarkers.Expert opinion: Tears, saliva, and breath samples can provide valuable information about viral infections. Our brief review strongly recommends the application of saliva/tears and exhaled breath as clinical samples using technics such as high-performance liquid chromatography-laser-induced fluorescence, photoacoustic spectroscopy, and e-Nose, respectively, for the fast diagnosis of viral infections.


Assuntos
/diagnóstico , /isolamento & purificação , Biomarcadores/metabolismo , Líquidos Corporais/virologia , Testes Respiratórios , Cromatografia Líquida , Expiração , Humanos , Lasers , Programas de Rastreamento/métodos , Nanotecnologia , Técnicas Fotoacústicas , Saliva/virologia , Sensibilidade e Especificidade , Lágrimas/virologia
11.
Sensors (Basel) ; 21(2)2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33445436

RESUMO

Human breath is a biomarker of body fat metabolism and can be used to diagnose various diseases, such as diabetes. As such, in this paper, a vacuum ultraviolet (VUV) spectroscopy system is proposed to measure the acetone in exhaled human breath. A strong absorption acetone peak at 195 nm is detected using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding to the VUV region. The hollow-core fiber functions both as a long-path and an extremely small-volume gas cell; it enables us to sensitively measure the trace components of exhaled breath. For breath analysis, we apply multiple regression analysis using the absorption spectra of oxygen, water, and acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. Based on human breath, we apply the standard addition method to obtain the measurement accuracy. The results suggest that the standard deviation is 0.074 ppm for healthy human breath with an acetone concentration of around 0.8 ppm and a precision of 0.026 ppm. We also monitor body fat burn based on breath acetone and confirm that breath acetone increases after exercise because it is a volatile byproduct of lipolysis.


Assuntos
Acetona/análise , Testes Respiratórios/métodos , Espectrofotometria Ultravioleta/métodos , Tecido Adiposo/metabolismo , Testes Respiratórios/instrumentação , Desenho de Equipamento , Exercício Físico , Voluntários Saudáveis , Humanos , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Fibras Ópticas , Análise de Regressão , Sensibilidade e Especificidade , Espectrofotometria Ultravioleta/instrumentação , Vácuo , Compostos Orgânicos Voláteis/análise , Adulto Jovem
12.
ACS Appl Mater Interfaces ; 13(4): 5602-5613, 2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33496182

RESUMO

Respiration monitoring and human sweat sensing have promising application prospects in personal healthcare data collection, disease diagnostics, and the effective prevention of human-to-human transmission of fatal viruses. Here, we have introduced a unique respiration monitoring and touchless sensing system based on a CsPb2Br5/BaTiO3 humidity-sensing layer operated by water-induced interfacial polarization and prepared using a facile aerosol deposition process. Based on the relationship between sensing ability and layer thickness, the sensing device with a 1.0 µm thick layer was found to exhibit optimal sensing performance, a result of its ideal microstructure. This sensor also exhibits the highest electrical signal variation at 0.5 kHz due to a substantial polarizability difference between high and low humidity. As a result, the CsPb2Br5/BaTiO3 sensing device shows the best signal variation of all types of breath-monitoring devices reported to date when used to monitor sudden changes in respiratory rates in diverse situations. Furthermore, the sensor can effectively detect sweat evaporation when placed 1 cm from the skin, including subtle changes in capacitance caused by finger area and motion, skin moisture, and contact time. This ultrasensitive sensor, with its fast response, provides a potential new sensing platform for the long-term daily monitoring of respiration and sweat evaporation.


Assuntos
Compostos de Bário/química , Técnicas Biossensoriais/instrumentação , Compostos de Bromo/química , Respiração , Suor/química , Titânio/química , Testes Respiratórios/instrumentação , Césio/química , Desenho de Equipamento , Humanos , Umidade , Chumbo/química , Monitorização Fisiológica/instrumentação , Nanocompostos/química
14.
Methods Mol Biol ; 2130: 149-156, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33284442

RESUMO

Metabolites like melatonin are essential in determining circadian phase. In the recent years, comprehensive metabolome analyses have unveiled entire panels of small biomolecules fluctuating in a circadian fashion, thus enabling a more precise determination of inner time and understanding of how circadian clock operates at the molecular level. Emerging analytical techniques allowing for the determination of exhaled metabolites in breath show promise to gain further insights noninvasively and in vivo into circadian metabolism.


Assuntos
Ritmo Circadiano , Expiração , Metaboloma , Metabolômica/métodos , Espectrometria de Massas por Ionização por Electrospray/métodos , Testes Respiratórios/instrumentação , Testes Respiratórios/métodos , Humanos , Espectrometria de Massas por Ionização por Electrospray/instrumentação
15.
Aliment Pharmacol Ther ; 53(5): 608-615, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33368499

RESUMO

BACKGROUND: Chronic use of proton pump inhibitors (PPIs) in patients with impaired liver function may worsen cytochrome P450 (CYP450) activity, predisposing them to clinically relevant drug-drug interactions. The 13 C-aminopyrine breath test (13 C-ABT) is a non-invasive tool to study CYP450-dependent liver function. AIMS: To assess 13 C-ABT modifications with different PPIs in patients with cirrhosis METHODS: Sixty consecutive patients with HCV-related cirrhosis and indication to start PPI therapy were randomised to receive omeprazole 20 mg/day, esomeprazole 20 mg/day, lansoprazole 15 mg/day, pantoprazole 40 mg/day or rabeprazole 20 mg/day. 13 C-ABT was performed at baseline and on the 15th day of PPI therapy. RESULTS: At baseline, mean values of max 13 C% dose/h and 13 C% cum dose at 120 minutes did not differ significantly among groups. On the 15th day of therapy, max 13 C% dose/h and 13 C% cum dose at 120 minutes did not significantly differ with respect to baseline for pantoprazole (P = 0.184 and P = 0.309, respectively) or rabeprazole (P = 0.536 and P = 0.286, respectively), but were significantly decreased on omeprazole (P = 0.013 and P = 0.015, respectively), esomeprazole (P = 0.009 and P = 0.001, respectively), and lansoprazole (P = 0.033 and P = 0.035, respectively). CONCLUSIONS: In patients with cirrhosis, omeprazole, esomeprazole and lansoprazole inhibit microsomal activity while pantoprazole and rabeprazole do not have a significant impact. Should our data be confirmed in larger cohort studies, pantoprazole and rabeprazole could be safely recommended for patients with cirrhosis.


Assuntos
Antiulcerosos , Inibidores da Bomba de Prótons , 2-Piridinilmetilsulfinilbenzimidazóis , Aminopirina , Testes Respiratórios , Sistema Enzimático do Citocromo P-450 , Esomeprazol , Humanos , Lansoprazol , Cirrose Hepática/tratamento farmacológico , Rabeprazol
16.
ACS Appl Mater Interfaces ; 13(1): 219-232, 2021 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-33375776

RESUMO

The application of biodegradable and biocompatible materials to triboelectric nanogenerators (TENGs) for harvesting energy from motions of the human body has been attracting significant research interest. Herein, we report diatom bio-silica as a biomaterial additive to enhance the output performance of cellulose nanofibril (CNF)-based TENGs. Diatom frustules (DFs), which are tribopositive bio-silica having hierarchically porous three-dimensional structures and high surface area, have hydrogen bonds with CNFs, resulting in enhanced electron-donating capability and a more roughened surface of the DF-CNF composite film. Hence, DFs were applied to form a tribopositive composite film with CNFs. The DF-CNF biocomposite film is mechanically strong, electron-rich, low-cost, and frictionally rough. The DF-CNF TENG showed an output voltage of 388 V and time-averaged power of 85.5 mW/m2 in the contact-separation mode with an efficient contact area of 4.9 cm2, and the generated power was sufficient for instantaneous illumination of 102 light-emitting diodes. In addition, a cytotoxicity study and biocompatibility tests on rabbit skin suggested that the DF-CNF composite was biologically safe. Moreover, a practical application of the DF-CNF TENG was examined with a self-powered smart mask for human breathing monitoring. This study not only suggests high output performance of biomaterial-based TENGs but also presents the diverse advantages of the DFs in human body-related applications such as self-powered health monitoring masks, skin-attachable power generators, and tactile feedback systems.


Assuntos
Celulose/química , Fontes de Energia Elétrica , Máscaras , Nanofibras/química , Dióxido de Silício/química , Dispositivos Eletrônicos Vestíveis , Animais , Testes Respiratórios/instrumentação , Celulose/toxicidade , Diatomáceas/química , Eucalyptus/química , Humanos , Masculino , Monitorização Fisiológica/instrumentação , Nanofibras/toxicidade , Coelhos , Dióxido de Silício/toxicidade , Pele/efeitos dos fármacos , Resistência à Tração
18.
Anal Chem ; 93(2): 1170-1178, 2021 01 19.
Artigo em Inglês | MEDLINE | ID: mdl-33315383

RESUMO

Methanol poisoning outbreaks after consumption of adulterated alcohol frequently overwhelm health care facilities in developing countries. Here, we present how a recently developed low-cost and handheld breath detector can serve as a noninvasive and rapid diagnostic tool for methanol poisoning. The detector combines a separation column and a micromachined chemoresistive gas sensor fully integrated into a device that communicates wirelessly with a smartphone. The performance of the detector is validated with methanol-spiked breath of 20 volunteers (105 breath samples) after consumption of alcoholic beverages. Breath methanol concentrations were quantified accurately within 2 min in the full breath-relevant range (10-1000 ppm) in excellent agreement (R2 = 0.966) with benchtop mass spectrometry. Bland-Altman analysis revealed sufficient limits of agreement (95% confidence intervals), promising to indicate reliably the clinical need for antidote and hemodialysis treatment. This simple-in-use detector features high diagnostic capability for accurate measurement of methanol in spiked breath, promising for rapid screening of methanol poisoning and assessment of severity. It can be applied readily by first responders to distinguish methanol from ethanol poisoning and monitor in real time the subsequent hospital treatment.


Assuntos
Testes Respiratórios , Metanol/análise , Humanos , Espectroscopia de Infravermelho com Transformada de Fourier
19.
Int J Mol Sci ; 21(24)2020 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-33321951

RESUMO

Respiratory tract infections are common, and when affecting the lower airways and lungs, can result in significant morbidity and mortality. There is an unfilled need for simple, non-invasive tools that can be used to screen for such infections at the clinical point of care. The electronic nose (eNose) is a novel technology that detects volatile organic compounds (VOCs). Early studies have shown that certain diseases and infections can result in characteristic changes in VOC profiles in the exhaled breath. This review summarizes current knowledge on breath analysis by the electronic nose and its potential for the detection of respiratory diseases with and without infection.


Assuntos
Asma/diagnóstico , Nariz Eletrônico , Neoplasias Pulmonares/diagnóstico , Infecções Respiratórias/diagnóstico , Animais , Asma/metabolismo , Testes Respiratórios/instrumentação , Testes Respiratórios/métodos , Humanos , Neoplasias Pulmonares/metabolismo , Infecções Respiratórias/metabolismo , Compostos Orgânicos Voláteis/análise , Compostos Orgânicos Voláteis/metabolismo
20.
Ter Arkh ; 92(6): 69-72, 2020 Jul 09.
Artigo em Russo | MEDLINE | ID: mdl-33346495

RESUMO

AIM: Conducting a pilot study to assess the effect of thermal heliox on the state of the respiratory tract by studying of the exhaled breath condensate protein composition before the thermal heliox procedure, immediately after and after three hours of relaxation Materials and methods. A comparative study of the exhaled breath condensates (EBC) protein composition of five non-smoking healthy donors was carried out. The EBC was taken before the respiratory procedure, immediately after a 20-minute inhalation by mixture of He/O2 gases (70/30) heated to 70C and 3 hours later. The protein composition was determined by chromatography-mass spectrometric analysis after selective tryptic hydrolysis. The results were processed using the Mascot program and the UniProt database. RESULTS: After the heliox procedure, the volume of the collected condensate (11.5 ml) decreases by an average of 32% and is practically restored after three hours of relaxation. Most proteins were consistent for all samples, regardless of the thermal heliox procedure. These are keratins, several proteins of the immune system (immunoglobulins, compliment proteins), tubulin. In samples after thermal heliox, the appearance of small amounts of additional proteins is observed. These are proteins of muscle metabolism (actin and calmodulin), fibrinogen, traces of hemoglobin, apolipoprotein, type B creatine kinase. After three hours of relaxation, tubulin disappears in the EBC. CONCLUSION: Most exhaled proteins are the same before, after the procedure, and for three hours of relaxation. The results obtained demonstrate the relative safety of the use of high temperature heliox as a therapeutic agent.


Assuntos
Testes Respiratórios , Proteoma , Hélio , Humanos , Masculino , Oxigênio , Projetos Piloto , Sistema Respiratório , Temperatura
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