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3.
Am J Psychoanal ; 80(3): 342-353, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32796907

RESUMO

This paper explores the relationship between human desire, technology, and imagination, emphasizing (1) the phenomenology of this relationship, and (2) its ontological and ecological ramifications. Drawing on the work of Bion and Winnicott, the paper will develop a psychoanalytic container for attitudes contributing to our current climate-based crisis, paying special attention to the problematic effect technology has had on our sense of time and place. Many of our technologies stunt sensuous engagement, collapse psychic space, diminish our capacity to tolerate frustration, and blind us to our dependence on worlds beyond the human. In short, our technologies trouble our relationship to our bodies and other bodies. The paper argues that omnipotent fantasies organizing our relationship to technology, to each other, and to the nonhuman world, have cocooned us in a kind of virtual reality that devastates a sense of deep obligation to the environment.


Assuntos
Infecções por Coronavirus , Pandemias , Pneumonia Viral , Interpretação Psicanalítica , Terapia Psicanalítica/tendências , Isolamento Social/psicologia , Terapia de Exposição à Realidade Virtual/tendências , Betacoronavirus , Mudança Climática , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/psicologia , Psicologia Ambiental/tendências , Humanos , Pneumonia Viral/epidemiologia , Pneumonia Viral/psicologia , Teoria Psicanalítica , Psicologia , Transferência de Tecnologia
7.
Zhonghua Wei Chang Wai Ke Za Zhi ; 23(6): 557-561, 2020 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-32521974

RESUMO

Medical artificial intelligence is a deeply integrated field of production-university-research. The collaborative innovation system of "industry, education and research" has broken down the barriers between various disciplines and has shown great impetus in scientific and technological innovation and achievement transformation. The Affiliated Hospital of Qingdao University where the authors work, relying on Shandong Key Laboratory of Digital Medicine and Computer-Assisted Surgery and Institute of Digital Medicine and Computer-Assisted Surgery of Qingdao University, has jointly established a close "industry-university-research" cooperation mechanism with the State Key Laboratory of Virtual Reality Technology and Systems of Beijing University of Aeronautics and Astronautics and Qingdao Hisense Medical Equipment Co., Ltd., which lasted for 10 years and carried out a series of useful explorations in scientific and technological innovation and achievement transformation in the field of gastrointestinal surgery of artificial intelligence with fruitful results. It mainly comprises of the following: (1) The research and development (R&D) of Hisense computer-assisted surgery (CAS) system has important clinical significance for laparoscopic gastrointestinal surgery guided by surrounding blood vessels that grasps globally the movement and variation of blood vessels in order to accurately select surgical strategies. (2) R&D of an automatic identification system for gastrointestinal diseases (namely image-assisted diagnosis system of artificial intelligence) initially applies deep neural network of artificial intelligence to the identification of lymph node metastases in rectal cancer, which has achieved accurate clinical diagnosis. (3) The virtual endoscopy platform for the gastrointestinal tract developed can successfully provide a new virtual endoscopy view of the intestinal wall eversion and realize the one-way navigation of the intestinal wall. (4) A localized platform of laparoscopic surgery simulation training is established with completely independent intellectual property rights. We realize that clinical requirement is the source of research and development, clinical practice is the source of innovation, and clinicians are practitioners of transformation of achievements. The establishment of artificial intelligence models often requires the support of massive and high-quality clinical data. Therefore, the effectiveness of its promotion and application can only be ensured by adopting a multi-center research approach. In the whole process of scientific and technological innovation and achievement transformation, the issues of medical ethics and intellectual property rights cannot be ignored.


Assuntos
Inteligência Artificial , Procedimentos Cirúrgicos do Sistema Digestório/tendências , Invenções , Pesquisa Biomédica , Tecnologia Biomédica , Humanos , Transferência de Tecnologia
8.
Zhonghua Wei Chang Wai Ke Za Zhi ; 23(6): 562-565, 2020 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-32521975

RESUMO

The combination of medicine and engineering is a new interdisciplinary subject, which is a mode of cross integration and collaborative innovation between medical science and engineering. The combination and collaborative innovation of medicine and industry means more about the improvement, innovation and R&D of medical devices. However, the combination of traditional industry with biomedical engineering, modern medical imaging technology, electronic information technology and other high-tech in medical device industry is a reflection of the manufacturing industry and high-tech level of a country. The development mode of medical industry integration and collaborative innovation in China is mainly to merge medical colleges and universities with science and engineering colleges, promote the cross of different departments, and set up biomedical engineering specialty under the support of a series of relevant national policies, relying on large-scale comprehensive hospitals and research institutes, establish numerous research centers of translational medicine, thus achieving a series of achievements. Our team has made some explorations in the practice of the combination of medicine and engineering, including the utility model patent "reusable simple anal expander" and "incision protective cover of transanal multi-channel endoscopic surgery operation platform", which have been authorized by the State Intellectual Property Office, meanwhile the ultra-fine laparoscope, intragastric gasbag and other projects have been demonstrated by relevant research and development teams and are to be transformed into production. On January 10, 2020, with the approval of Guangdong Pharmaceutical Association, the Medical Innovation and Transformation Expert Committee of Guangdong Pharmaceutical Association was established jointly with the representatives of medical colleagues, scientific research institutions and enterprises, who are interested in the combination of medical industry and collaborative innovation. This Committee provides a platform for the exchange of medical colleagues, scientific research institutions and enterprises. We realize that clinical practice is the source of the combination of medical workers and collaborative innovation, and clinicians are the driving force of the combination of medical workers and collaborative innovation. At present, the main problems faced by the development of medical industry integration in China are as follows: insufficient integration of medical industry integration disciplines in the basic research stage; less interaction of clinical application needs in the application research stage; difficult transformation of scientific research achievements; the unconnected whole chain of "production, learning, research and application". If we can increase the investment in scientific research and policy incentives, strengthen the communication and interaction with enterprises, pay more attentions to the social and economic benefits of the promotion of achievements, open the whole process of the combination of medicine and industry, and improve the evaluation mechanism of the innovation ability of such combination, combination of medicine and engineering and collaborative innovation in China will enter the golden period of rapid development.


Assuntos
Invenções , Procedimentos Cirúrgicos Operatórios , Transferência de Tecnologia , Pesquisa Biomédica , Tecnologia Biomédica , China , Humanos , Propriedade Intelectual , Universidades
9.
PLoS One ; 15(6): e0233632, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32492039

RESUMO

Increasing pandemic influenza vaccine manufacturing capacity is considered strategic by WHO. Adjuvant use is key in this strategy in order to spare the vaccine doses and by increasing immune protection. We describe here the production and stability studies of a squalene based oil-in-water emulsion, adjuvant IB160, and the immune response of the H7N9 vaccine combined with IB160. To qualify the production of IB160 we produced 10 consistency lots of IB160 and the average results were: pH 6.4±0.05; squalene 48.8±.0.03 mg/ml; osmolality 47.6±6.9 mmol/kg; Z-average 157±2 nm, with polydispersity index (PDI) of 0.085±0.024 and endotoxin levels <0.5 EU/mL. The emulsion particle size was stable for at least six months at 25°C and 24 months at 4-8°C. Two doses of H7N9 vaccine formulated at 7.5 µg/dose or 15 µg/dose with adjuvant IB160 showed a significant increase of hemagglutination inhibition (HAI) titers in sera of immunized BALB/c mice when compared to control sera from animals immunized with the H7N9 antigens without adjuvant. Thus the antigen-sparing capacity of IB160 can potentially increase the production of the H7N9 pandemic vaccine and represents an important achievement for preparedness against pandemic influenza and a successful North (IDRI) to South (Butantan Institute) technology transfer for the production of the adjuvant emulsion IB160.


Assuntos
Adjuvantes Farmacêuticos/síntese química , Emulsões/síntese química , Subtipo H7N9 do Vírus da Influenza A/imunologia , Influenza Humana/epidemiologia , Influenza Humana/prevenção & controle , Infecções por Orthomyxoviridae/prevenção & controle , Pandemias/prevenção & controle , Adjuvantes Farmacêuticos/química , Animais , Brasil/epidemiologia , Estabilidade de Medicamentos , Emulsões/química , Testes de Inibição da Hemaglutinação , Humanos , Vacinas contra Influenza/imunologia , Influenza Humana/virologia , Camundongos , Camundongos Endogâmicos BALB C , Infecções por Orthomyxoviridae/virologia , Polissorbatos/química , Esqualeno/química , Transferência de Tecnologia , Vacinação/métodos
11.
Comput Inform Nurs ; 38(8): 393-401, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32427610

RESUMO

The current standard in healthcare research is to maintain scientific fidelity of any intervention being tested. Fidelity is defined as the consistent delivery of interventions that ensures that all participants are provided the same information, guidance, and/or materials. Notably, the methods for ensuring fidelity of intervention delivery must also be consistent. This article describes our Intervention and Technology Delivery Fidelity Checklists used to ensure consistency. These checklists were completed by trained nurse observers who rated the intervention implementation and the technology delivery. Across our clinical trials and pilot studies, the fidelity scores were tabulated and compared. Intervention information and materials were delivered by a variety of devices including telehealth monitors, videophones, and/or iPads. Each of the devices allows audiovisual connections between health professionals from their offices and patients and participants in their homes. Our checklists guide the monitoring of fidelity of technology delivery. Overall checklist ratings across our studies demonstrate consistent intervention, implementation, and technology delivery approaches. Uniquely, the fidelity checklist verifies the interventionist's correct use of the technology devices to ensure consistent audiovisual delivery. Checklist methods to ensure intervention fidelity and technology delivery are essential research procedures, which can be adapted for use by researchers across multiple disciplines.


Assuntos
Confiabilidade dos Dados , Pesquisa/normas , Transferência de Tecnologia , Telemedicina/métodos , Lista de Checagem/instrumentação , Humanos , Projetos Piloto , Pesquisa/tendências , Telemedicina/tendências
12.
PLoS Negl Trop Dis ; 14(4): e0008206, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32320398

RESUMO

During the West African Ebola Virus Disease (EVD) epidemic from 2014 to 2016, a variety of technologies travelled considering the context of the emergency: a highly contagious fast-killing disease outbreak with no known remedy and a rapidly increasing number of cases. The Ebola-Tx clinical trial tested the efficacy of Convalescent Plasma (CP) as a treatment for EVD in Guinea. This paper is based on ethnographic research in the Ebola-Tx trial and focuses on the introduction of a mobile plasma collection centre, referred to as the 'Plasma Mobile', equipped with plasmapheresis and pathogen inactivation technologies, as well as how the transfer itself of this technology entailed complex effects on CP donors as trial participants (i.e. providers of the therapeutic product), directly involved staff and more broadly on the trial implementation as a whole. The transfer led to the emergence of a dimension of hope as CP donors hoped that the plasma would cure and, as providers of the therapeutic, hoped it would decrease their stigmatization and the economic impact of the disease. We conclude that, in light of the intricate effects that the transfer of such health technology can entail-in the localization to the specific context, as well as in the consequences they can have on actors involved in the implementation of such technologies-global health technologies should be put at the services of next epidemic and pandemic (preparedness) on condition that they are accompanied by an understanding of the technologies' own cultural meanings and social understandings.


Assuntos
Doadores de Sangue/psicologia , Doença pelo Vírus Ebola/prevenção & controle , Doença pelo Vírus Ebola/terapia , Unidades Móveis de Saúde , Tecnologia Biomédica , Feminino , Guiné , Humanos , Masculino , Motivação , Participação do Paciente , Plasmaferese/métodos , Sobreviventes/psicologia , Transferência de Tecnologia
13.
FEMS Microbiol Lett ; 367(5)2020 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-32149346

RESUMO

The European Culture Collections' Organisation presents two new model documents for Material Deposit Agreement (MDA) and Material Transfer Agreement (MTA) designed to enable microbial culture collection leaders to draft appropriate agreement documents for, respectively, deposit and supply of materials from a public collection. These tools provide guidance to collections seeking to draft an MDA and MTA, and are available in open access to be used, modified, and shared. The MDA model consists of a set of core fields typically included in a 'deposit form' to collect relevant information to facilitate assessment of the status of the material under access and benefit sharing (ABS) legislation. It also includes a set of exemplary clauses to be included in 'terms and conditions of use' for culture collection management and third parties. The MTA model addresses key issues including intellectual property rights, quality, safety, security and traceability. Reference is made to other important tools such as best practices and code of conduct related to ABS issues. Besides public collections, the MDA and MTA model documents can also be useful for individual researchers and microbial laboratories that collect or receive microbial cultures, keep a working collection, and wish to share their material with others.


Assuntos
Biodiversidade , Pesquisa Biomédica/legislação & jurisprudência , Manejo de Espécimes , Transferência de Tecnologia , Europa (Continente) , Humanos
16.
Molecules ; 25(2)2020 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-31963295

RESUMO

It is often argued that DNA nanotechnology has a multitude of possible applications. However, despite great advances in the understanding of the fundamental principles of the field, to date, there has been comparatively little commercial activity. Analysis of patent applications and company case studies suggests that this is now starting to change. The number of patent application filings is increasing, and new companies are being formed to exploit technologies based on nanoscale structures and devices made from DNA. There are parallels between the commercial developments in this field and those observed in other areas of innovation. Further commercialization is expected and new players will emerge.


Assuntos
DNA/química , Nanotecnologia , Animais , Biotecnologia , Setor de Assistência à Saúde , Humanos , Nanotecnologia/métodos , Software , Transferência de Tecnologia
18.
Dev Biol ; 459(1): 30-32, 2020 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-31682810

RESUMO

The current academic and business landscape does not provide a clear path for doctoral trainees graduating. Moreover, the fundamental need of the hour is diversification of the workforce where PhD graduates need to be trained to do more beyond basic scientific research. One of the possible paths that is now becoming popular as science enters its translational phase is research commercialization and technology transfer. This short article provides an comprehensive overview of the technology transfer field and possible paths trainees can take to position themselves as a successful technology transfer professional.


Assuntos
Escolha da Profissão , Mobilidade Ocupacional , Comércio , Pesquisadores , Transferência de Tecnologia , Humanos , Descrição de Cargo , Aprendizagem , Masculino , Marketing , Negociação , Rede Social , Habilidades Sociais
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