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1.
Medicina (Kaunas) ; 57(1)2021 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-33435391

RESUMO

Background and objectives: Bipolar disorder (BD) is one of the most burdensome psychiatric illnesses, being associated with a negative long-term outcome and the highest suicide rate. Although affective temperaments can impact on BD long-term outcome, their role remains poorly investigated. The aims of the present study are to describe the clinical characteristics of patients with BD more frequently associated with the different affective temperaments and to assess the relation between affective temperaments and severity of clinical picture in a sample of patients with BD. Materials and Methods: A total of 199 patients have been recruited in the outpatients units of two university sites. Patients' psychiatric symptoms, affective temperaments, and quality of life were investigated through validated assessment instruments. Results: Predominant cyclothymic and irritable temperaments are associated to higher number of relapses, poorer quality of life, higher rates of aggressive behaviors, and suicide attempts. Conversely, the predominant hyperthymic disposition was a protective factor for several outcome measures, including relapse rate, severity of anxiety, depressive and manic symptoms, suicidality, and earlier age at onset. One limitation of the present study is that the recruitment took place in two university sites; therefore, our findings cannot be fully generalized to the whole community of BD patients. Other limitations are the lack of a control group and the cross-sectional design of the study. Conclusions: The early identification of affective temperaments can help clinicians to identify those BD patients who are more likely to show a poor long-term outcome. An early screening of affective temperaments can be useful to develop targeted integrated pharmacological and psychosocial interventions.


Assuntos
Transtorno Bipolar/psicologia , Transtorno Ciclotímico/psicologia , Humor Irritável , Qualidade de Vida/psicologia , Temperamento , Adulto , Afeto , Idade de Início , Agressão/psicologia , Ansiedade/psicologia , Transtorno Bipolar/fisiopatologia , Depressão/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Índice de Gravidade de Doença , Ideação Suicida , Tentativa de Suicídio/psicologia
2.
Psychiatr Danub ; 32(3-4): 346-350, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33370731

RESUMO

The comorbidity of bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is widely known. The overall rate of association between BD and OCD is very high and varies, depending on the authors, from 11% to 18%, with peaks of 21% in primarily bipolar patients. Vice versa, about 60% of patients with OCD have a second psychiatric diagnosis, which in 23% of cases turns out to be BD. The differences between the BD patients with and without OCD were so numerous and important (e.g., different onset of mood episodes, history of suicide attempts, seasonality, rapid cycling and impulsivity) that the comorbidity between BD and OCD may represent a distinct form of BD, similar to cyclothymic BD for psychopathological features. However, the comorbidity does not seem to have any impact on cognitive performance, such as there is no specific difference between patients who first develop BD and then OCD or vice versa. Anyway, the detection of the neurocognitive profile of these patients at the time of the first clinical evaluation could have clinical implications also in the therapeutic and rehabilitative management of this type of patient. Indeed, it would be desirable to develop a new model of rehabilitation that is less differentiated for both BD and OCD or for their comorbidity, also to make cognitive rehabilitation faster and less expensive. The purpose of this mini-review is to update the knowledge currently available on the impact of BD and OCD comorbidity on neurocognitive profile.


Assuntos
Transtorno Bipolar/epidemiologia , Transtorno Bipolar/psicologia , Testes de Estado Mental e Demência , Transtorno Obsessivo-Compulsivo/epidemiologia , Transtorno Obsessivo-Compulsivo/psicologia , Transtorno Bipolar/diagnóstico , Comorbidade , Humanos , Comportamento Impulsivo , Transtorno Obsessivo-Compulsivo/diagnóstico , Tentativa de Suicídio
3.
Psychiatr Danub ; 32(3-4): 351-358, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33370732

RESUMO

BACKGROUND: Retina is considered as a window to the brain due to the similarities in terms of development and pathologies. Optical coherence tomography (OCT) can perform quantitative examinations in the retina. In this study, we aimed to investigate the effects of drugs used in schizophrenia and bipolar disorder (BD) on retinal nerve fiber layer (RNFL) and macular thickness. SUBJECTS AND METHODS: The study included schizophrenia (n=35) and euthymic BD (n=46) patients on various medications, and age, gender matched healthy control group (n=31). For retinal evaluation, measurements of RNFL and macula were performed with Optovue RTVue Premier OCT. RESULTS: In the schizophrenia group, chlorpromazine equivalent dose of antipsychotics was a statistically significant negative predictor of left RNFL nasal superior region thickness. In the BD group, serum valproate level was a significant positive predictor of thickness in the right macular inferior outer, left macular nasal outer region, right RNFL inferotemporal, left temporal and inferotemporal regions. CONCLUSION: Since the retina consists of neurons, morphological or functional examination of retina may be beneficial for the evaluation of the effects of psychopharmalogical treatments in schizophrenia and BD. The outcome of this study implies that valproate has neuroprotective effects on the optic nerve and macula, and this finding is consistent with the literature implying neurotrophic effects of valproate.


Assuntos
Transtorno Bipolar/diagnóstico por imagem , Transtorno Bipolar/tratamento farmacológico , Retina/efeitos dos fármacos , Retina/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/tratamento farmacológico , Tomografia de Coerência Óptica , Adulto , Feminino , Humanos , Macula Lutea/diagnóstico por imagem , Macula Lutea/efeitos dos fármacos , Masculino , Fibras Nervosas/efeitos dos fármacos
4.
Psychiatr Danub ; 32(3-4): 373-379, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33370735

RESUMO

BACKGROUND: Regular practice of physical activity is associated with better quality of life and functioning in people with bipolar disorder, schizophrenia and depression. However, to the best of our knowledge, there is no evidence of the association between physical activity and quality of life and global functioning among people in the initial stages of psychosis. The aim to explore the association of the level of physical activity with quality of life and global functioning among patients in early stages of psychosis. SUBJECTS AND METHODS: Cross-sectional study carried out in an early intervention program in 2016. The socio-demographic and clinical variables were assessed via a form; the adherence through the Measurement of Treatment Adherence; the global functioning through the Global Assessment of Functioning (GAF) scale; the level of physical activity through the International Physical Activity Questionnaire (IPAQ) and quality of life through the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). The Mann-Whitney test was used for analysis. RESULTS: A total of eighty-five participants (mean age=32, 57.6% were men) were assessed. Of the 85, 46 (54.1%) were classified as physically active. The physically active patients presented higher values, on average (standard deviation), in relation to the SF-36 domain of physical functioning (active patients: 87.1 (20.9) vs. inactive patients 80.1 (20.5) inactive; p=0.016), and global functioning when compared to the physically inactive group (active patients: 71.5 (17.6) vs. inactive patients 60.1 (20.9); p=0.011). CONCLUSION: Higher levels of physical activity are associated with better quality of life and higher global functioning in patients in early stages of psychosis.


Assuntos
Transtorno Bipolar/fisiopatologia , Depressão/fisiopatologia , Exercício Físico , Qualidade de Vida , Esquizofrenia/fisiopatologia , Adulto , Estudos Transversais , Feminino , Humanos , Masculino
5.
Artigo em Russo | MEDLINE | ID: mdl-33340295

RESUMO

OBJECTIVE: To comparare socio-demographic and clinical characteristics of patients with the first depressive episode and recurrent depression. MATERIAL AND METHODS: Three hundred and twenty one patients with unipolar depression, including 96 patients with first depressive episode and 225 patients with recurrent depression, were examined using clinical and psychometric methods. RESULTS AND CONCLUSION: There were differences in clinical characteristics between groups but such factors as gender, marital status, level of education, family history of mental disorders and personality were similar. With each new episode of recurrent depression, the next episode tends to be more severe with more intense pessimistic and suicidal thoughts but fewer anxiety and complaints of depressive mood that affects the differences and requires further research, especially considering the effect of therapy.


Assuntos
Transtorno Bipolar , Transtorno Depressivo Maior , Afeto , Depressão/diagnóstico , Depressão/epidemiologia , Humanos , Psicometria
6.
Zh Nevrol Psikhiatr Im S S Korsakova ; 120(11): 108-115, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33340305

RESUMO

However, despite successful use of lithium in the treatment of affective disorders for almost 40 years, the mechanisms of its therapeutic action are still poorly understood. This review presents and summarizes the current literature about the use of lithium in treatment of affective disorders, as well as its effects on cellular physiology, with a separate description of the effect of this ion on the functioning of nerve tissue and ion-molecular mechanisms.


Assuntos
Transtorno Bipolar , Psicofarmacologia , Transtorno Bipolar/tratamento farmacológico , Humanos , Lítio/farmacologia , Lítio/uso terapêutico , Transtornos do Humor/tratamento farmacológico
7.
Belo Horizonte; Faculdade de Medicina da UFMG; 20200000. 45 p.
Monografia em Português | LILACS, BDENF - Enfermagem, Coleciona SUS | ID: biblio-1129036

RESUMO

A XVII Jornada Acadêmica de Saúde mental é um evento que busca aproximar os estudantes de cursos variados do campo de estudo da Saúde Mental. Além de aulas ministradas na forma de palestras, os acadêmicos são convidados a produzirem trabalhos para serem apresentados aos demais participantes, ampliando o leque de assuntos abordados. Além de proporcionar aos estudantes interessados maior contato com temas específicos da área, a produção de resumos para apresentação é uma ferramenta para aprimoramento das técnicas de escrita e produção de conteúdo. Elaborar os trabalhos amplia os conhecimentos dos alunos sobre escrita científica e os aproxima do meio acadêmico científico. Ademais, o contato com professores e pesquisadores da área, que orientam os participantes durante o processo, cria canais de comunicação e abre novas oportunidades para os estudantes. Para esta edição do evento, os trabalhos foram selecionados pela Comissão Científica da Jornada, que verificou um alto nível nas submissões. Aqueles mais originais, relevantes e bem produzidos foram aprovados e compõem esse livro, mostrando à comunidade a qualidade dos estudantes e do conteúdo apresentado na XVII JASME. Os assuntos discutidos nos próximos capítulos, desenvolvidos por estudantes de cursos da área da saúde, abrangem a saúde mental por variados ângulos e sob diversas abordagens. Escolher alguns trabalhos significa, necessariamente, prescindir de outros. Cientes do desafio de estabelecer uma coletânea que tivesse o padrão de qualidade e a feição da UFMG sem nos obnubilar pela subjetividade, estabelecemos critérios objetivos e submetemos cada resumo à apreciação independente de pelo menos três integrantes da junta científica para apreciação. Por fim, aferimos que não houve divergência de rigor entre os subgrupos e selecionamos os trinta melhores, ou seja, os mais inovadores, bem escritos, objetivos e bem fundamentados. Procuramos, diante dos diversos recortes da pandemia da COVID-19, incluir aqueles que, em vez de vagos de tão abrangentes, descreviam impactos tangíveis, mensuráveis e inusitados, isto é, Relacionados a grupos que não têm sido abordados pela grande mídia e tampouco pelo profissional de saúde médio. Assim, cremos que os resumos a seguir são os que mais bem abordam tanto questões atemporais em saúde mental quanto aquelas que emergiram nos últimos meses e ainda não sabemos por quanto tempo perdurarão. Os trabalhos tratam desde questões relacionadas aos fatores de risco para o desenvolvimento de transtornos psiquiátricos aos aspectos do tratamento farmacológico. Com uma perspectiva atual e relevante para as condições de saúde vigente, as temáticas se relacionam com diversas áreas da saúde mental, como as consequências da pandemia da SARS-COV2, aspectos da saúde mental em jovens e idosos, condutas da saúde mental na saúde primária, psicofarmacologia, transtornos psiquiátricos.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Esquizofrenia , Isolamento Social/psicologia , Suicídio , Transtorno Bipolar , Idoso , Cannabis/toxicidade , Ácidos Graxos Ômega-3/uso terapêutico , Saúde Mental , Adolescente , Pessoal de Saúde/psicologia , Infecções por Coronavirus , Depressão Pós-Parto , Depressão , Alcoolismo , Pandemias , Transtorno do Espectro Autista , Hipotireoidismo/psicologia
8.
Artigo em Inglês | MEDLINE | ID: mdl-33166098

RESUMO

Objective: To report the clinical characteristics and transmission rate of coronavirus disease 2019 (COVID-19) in a community inpatient long-term care psychiatric rehabilitation facility designed for persons with serious mental illness to provide insight into transmission and symptom patterns and emerging testing protocols, as well as medical complications and prognosis. Methods: This study examined a cohort of 54 residents of a long-term care psychiatric rehabilitation program from March to April 2020. Baseline demographics, clinical diagnoses, and vital signs were examined to look for statistical differences between positive versus negative severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) groups. During the early phase of the pandemic, the facility closely followed the local shelter-in-place order (starting March 19, 2020) and symptom-based testing. Results: Of the residents, the primary psychiatric diagnoses were schizoaffective disorder: 28 (51.9%), schizophrenia: 21 (38.9%), bipolar I disorder: 3 (5.5%), and unspecified psychotic disorder: 2 (3.7%). Forty (74%) of 54 residents tested positive for SARS-COV-2, with a doubling time of 3.9 days. There were no statistical differences between the positive SARS-COV-2 versus negative groups for age or race/ethnicity. Psychiatric and medical conditions were not significantly associated with contracting SARS-COV-2, with the exception of obesity (n = 17 [43%] positive vs n = 12 [86%] negative, P = .01). Medical monitoring of vital signs and symptoms did not lead to earlier detection. All of the residents completely recovered, with the last resident no longer showing any symptoms 24 days from the index case. Conclusion: Research is needed to determine optimal strategies for long-term care mental health settings that incorporate frequent testing and personal protective equipment use to prevent rapid transmission of SARS-COV-2.


Assuntos
Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Transtornos Psicóticos/reabilitação , Centros de Reabilitação , Esquizofrenia/reabilitação , Adulto , Afro-Americanos , Americanos Asiáticos , Betacoronavirus , Transtorno Bipolar/epidemiologia , Transtorno Bipolar/reabilitação , California/epidemiologia , Técnicas de Laboratório Clínico , Comorbidade , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/transmissão , Diabetes Mellitus/epidemiologia , Grupo com Ancestrais do Continente Europeu , Refluxo Gastroesofágico/epidemiologia , Hispano-Americanos , Humanos , Hiperlipidemias/epidemiologia , Hipertensão/epidemiologia , Hipotireoidismo/epidemiologia , Controle de Infecções , Assistência de Longa Duração , Programas de Rastreamento , Pessoa de Meia-Idade , Obesidade/epidemiologia , Pandemias , Pneumonia Viral/diagnóstico , Pneumonia Viral/fisiopatologia , Pneumonia Viral/transmissão , Reabilitação Psiquiátrica , Psicoterapia de Grupo , Transtornos Psicóticos/epidemiologia , Recreação , Reabilitação Vocacional , Esquizofrenia/epidemiologia , Fumar/epidemiologia , Visitas a Pacientes
9.
Riv Psichiatr ; 55(5): 319-321, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33078024

RESUMO

CoViD-19 pandemic has created a global concern in the whole population. The psychiatric and social impact of the viral infection is recorded differently by the community. However, more vulnerable individuals with negative psychiatric history are presenting to mental health hospitals for admission, assessment and treatment due to abnormal reactions to CoViD-19 pandemic. The current study reports six clinical cases of first psychiatric presentation that were characterised by sudden onset of symptoms, manic and psychotic symptoms, adverse response to stress, psychomotor agitation and behaviours out of character. The presentation was short-lived and responded to typical antipsychotics and antidepressants. The posed diagnoses were acute and transient psychotic disorder and acute stress reaction.


Assuntos
Betacoronavirus , Transtorno Bipolar/etiologia , Infecções por Coronavirus/psicologia , Depressão/etiologia , Pneumonia Viral/psicologia , Transtornos Psicóticos/etiologia , Adulto , Infecções por Coronavirus/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/epidemiologia
10.
Artigo em Russo | MEDLINE | ID: mdl-33095531

RESUMO

OBJECTIVE: To compare monopolar and bipolar mapping in point-by-point fashion by using of threshold amperage, frequency of positive motor responses and the number of muscles involved in response. MATERIAL AND METHODS: A prospective non-randomized study included 14 patients with supratentorial tumors who underwent surgery in 2018-2019. All neoplasms were localized within 2 cm from the motor cortex and pyramidal tract. Age of patients ranged from 25 to 74 years. There were 9 women and 5 men. Eight patients had malignant glioma (grade III - 4, grade IV - 4), 6 patients - meningioma. Motor functions were assessed in all patients before and after surgery (1, 7 days and 3 months later) by using of a 5-point scale. In addition to routine neurophysiological monitoring, comparative mono- and bipolar mapping of the pyramidal tract within the bed of excised tumor was carried out at the end of surgery. The points of motor responses were marked. Comparative analysis of mono- and bipolar stimulation at identical points included threshold amperage, frequency of positive motor responses and the number of muscles involved in response (leg, forearm, hand, facial muscles). Brain MRI was performed in early postoperative period for assessment of resection quality. RESULTS: There were 64 points of motor responses in 14 patients. The number of these points ranged from 2 to 8 per a patient (mean 5 points). Motor responses were recorded in 57 points during monopolar and bipolar stimulation, in other 7 points - only during monopolar stimulation. Amperage of monopolar stimulation was 3-15 mA, bipolar stimulation - 2.5-25 mA. Threshold amperage (7.37 mA for monopolar stimulation and 8.88 mA for bipolar stimulation; p=0.12), frequency of positive motor responses and the number of muscles involved in response (p=0.1 and p=0.73) were similar. Seven (50%) patients had neurological deterioration in early postoperative period (4 patients with glial tumors and 3 patients with meningiomas). At the same time, only 2 patients (14.3%) had persistent neurological deficit (both patients with infiltrative meningioma). According to postoperative MRI in T1+C mode, resection volume was 100% in 1 patient with contrast-enhanced glioma and 94% in another one. According to FLAIR MRI data, resection volume exceeded 70% in 2 patients with non-enhancing glioma and less than 70% in 2 patients. Meningioma resection volume was estimated according to postoperative T1+C MRI data and made up over 90% in 4 patients. CONCLUSION: Monopolar stimulation is a reliable method of pyramidal tract identification in supratentorial brain tumor surgery.


Assuntos
Transtorno Bipolar , Neoplasias Encefálicas , Neoplasias Meníngeas , Córtex Motor , Neoplasias Supratentoriais , Mapeamento Encefálico , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Potencial Evocado Motor , Feminino , Humanos , Masculino , Monitorização Intraoperatória , Córtex Motor/diagnóstico por imagem , Estudos Prospectivos , Tratos Piramidais/diagnóstico por imagem , Neoplasias Supratentoriais/diagnóstico por imagem , Neoplasias Supratentoriais/cirurgia
11.
Medicine (Baltimore) ; 99(42): e22823, 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33080761

RESUMO

INTRODUCTION/RATIONALE: Multiple sclerosis (MS) is associated with a higher prevalence of mood and psychiatric disorders, such as bipolar disorder (BD). While mania is most often associated with BD, MS can also induce manic symptoms. However, it is crucial to distinguish which condition is causing mania since medical management is different based on its etiology. Herein, we report a case of a manic episode in a middle-aged female with a prolonged history of BD who received a recent diagnosis of MS 1 year ago. PATIENT CONCERNS: A 56-year-old female presented with an episode of mania and psychosis while receiving a phenobarbital taper for chronic lorazepam use. She had a prolonged history of bipolar type 1 disorder and depression. She showed optic neuritis and was diagnosed with MS a year prior. DIAGNOSES: The patient was diagnosed with BD-induced mania based on the absence of increased demyelination compared to previous MRI and lack of new focal or lateralizing neurologic findings of MS. INTERVENTIONS: Lithium was given for mood stabilization and decreased dosage of prior antidepressant medication. Risperidone was given for ongoing delusions. OUTCOMES: After 8 days of hospitalization, patient's mania improved but demonstrated atypical features and ongoing delusions. She was discharged at her request to continue treatment in an outpatient setting. CONCLUSION/LESSON: In BD patients with an episode of mania, MS should be included in the differential, since both conditions can cause manic symptoms. The origin of mania should be delineated through a detailed neurological exam, neuroimaging, and thorough patient-family psychiatric history for appropriate clinical treatment.


Assuntos
Transtorno Bipolar/psicologia , Esclerose Múltipla/psicologia , Antimaníacos/uso terapêutico , Antipsicóticos/uso terapêutico , Transtorno Bipolar/tratamento farmacológico , Feminino , Humanos , Compostos de Lítio/uso terapêutico , Pessoa de Meia-Idade , Risperidona/uso terapêutico
12.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 5635-5639, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33019255

RESUMO

Bipolar Disorder is a common mental illness affecting millions of people worldwide. It is most commonly presented as periods of depressive lows and manic highs, both of which can be extremely uncomfortable and distressing for the individual affected. Existing bipolar patient monitoring relies on subjective self-reports, which are inaccurate and biased. Moreover, many symptoms are not easily recognized or are ignored by the patient, resulting in a loss of information and misleading reports. To achieve reliable daily monitoring of dysfunctional behaviors, we propose a system mDB that uses a mobile phone to monitor a variety of symptomatic activities, in the hopes of improving care and quality of life for these individuals.


Assuntos
Transtorno Bipolar , Telefone Celular , Transtorno Bipolar/diagnóstico , Humanos , Monitorização Fisiológica , Qualidade de Vida
14.
Rev. enferm. Cent.-Oeste Min ; 10(1): 3489, out. 2020.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1129289

RESUMO

Objetivo: Descrever a predição de adesão ao tratamento e a percepção de qualidade de vida de pacientes com transtorno bipolar. Métodos: Estudo transversal realizado com 35 pacientes de um Centro de Atenção Psicossocial III. Foi utilizada uma escala de avaliação da predição da adesão ao tratamento e outra, para avaliar a qualidade de vida dos pacientes, realizou-se análise descritiva dos dados. Resultados: Observou-se maior predição de adesão nos aspectos relacionados à aliança terapêutica com os profissionais (91,4%); dificuldade em seguir o tratamento e efeitos adversos da medicação impactaram negativamente (91,4%). A maioria (77,2%) apresentou média de qualidade de vida regular. A qualidade de vida foi melhor no domínio relações sociais (31,5%) e pior no domínio meio ambiente (25,7%). Conclusão: É necessário construir estratégias de cuidado, pela Enfermagem, que minimizem os desconfortos da medicação e que promovam a reabilitação psicossocial, com o intuito de potencializar a adesão e promover a qualidade de vida dos pacientes.


Objective: To describe the prediction of treatment adherence and quality of life of patients with bipolar disorder. Methods: cross- sectional study with 35 patients from a Psychosocial Care Center III. Scales were used to assess the prediction of treatment adherence and the quality of life of the patients. Results: there was a higher prediction of adherence in aspects related to therapeutic alliance with professionals (91.4%), while difficulty in following treatment and adverse effects of medication caused a negatively impact (91.4%). Most (77.2%) had an average of regular quality of life. Quality of life was better in the social relations domain (31.5%) and worse in the environment domain (25.7%). Conclusion: it is necessary to build nursing care strategies that minimize medication discomfort and promote psychosocial rehabilitation, in order to enhance adherence and promote patients' quality of life.


Objetivo: describir la predeción de la adherencia al tratamiento y la calidad de vida de los pacientes con trastorno bipolar. Métodos: estudio transversal realizado con 35 pacientes de un Centro de Atención Psicosocial III. Se utilizaron escalas para la evaluación de la predicción de la adherencia al tratamiento y otra para evaluar la calidad de vida de los pacientes, se realizó el análisis descriptivo de los datos. Resultados: se observó mayor predicción de adherencia en los aspectos relacionados a la alianza terapéutica con los profesionales (91,4%); dificultad para seguir el tratamiento y efectos adversos de la medicación impactaron negativamente (91,4%). La mayoría (77,2%) presentó promedio de calidad de vida regular. La calidad de vida fue mejor en el dominio de relaciones sociales (31,5%), y peor en el dominio de medio ambiente (25,7%). Conclusión: es necesario desarrollar estrategias de atención de enfermería que minimicen la incomodidad de los medicamentos y promuevan la rehabilitación psicosocial, para mejorar la adherencia y promover la calidad de vida de los pacientes.


Assuntos
Qualidade de Vida , Transtorno Bipolar , Cooperação e Adesão ao Tratamento , Serviços de Saúde Mental
15.
Wiad Lek ; 73(8): 1780-1784, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33055351

RESUMO

OBJECTIVE: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system of a chronic nature, most often with periods of exacerbation and remission, mainly affecting people between 20-40 years of age, with a slight prevalence of women. The aim of the study was to collect and analyze materials published in the literature regarding the prevalence and co-occurrence of mental disorders in patients with multiple sclerosis. Current reports show that as many as 75% of patients with this chronic disease experience various mental disorders, and the incidence of mental diseases - including mood disorders and anxiety disorders - is statistically higher than in the general population. CONCLUSION: Conclusions: Depending on the literature, depressive symptoms appear in 6.94% -70.1% of patients with MS. Diagnosis of anxiety disorders affects 11.1% of patients, while bipolar disorder affects up to 16.2%. Co-occurrence of MS with schizophrenia is estimated at 1.28%. The incidence of other psychoses is 2-4% in patients with MS. Only in the case of schizophrenia, men with MS are more likely to develop it, while other psychiatric disorders are more common among women. Co-occurrence of mental disorders in the course of multiple sclerosis adversely affects the treatment process and the functioning of patients and their families.


Assuntos
Transtorno Bipolar , Esclerose Múltipla , Transtornos de Ansiedade , Transtorno Bipolar/epidemiologia , Comorbidade , Feminino , Humanos , Masculino , Esclerose Múltipla/complicações , Esclerose Múltipla/epidemiologia , Prevalência
16.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 837-840, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018115

RESUMO

Gastric motility is in part coordinated by bio-electrical slow waves. The wavefront orientation of the slow wave contains vital physiological information about the motility condition of the gastrointestinal system. Dysmotility was shown to be associated with dysrhythmic propagation of the slow wave. The most commonly used method to detect wavefront orientation is computationally expensive because of the involvement of activation time identification. The information of local directionality contained in bipolar slow wave recordings could be used to detect the wavefront orientation. An algorithm called bipolar direction detection was developed to utilize the information contained in the bipolar slow wave recordings. Bipolar recordings were constructed by subtracting the unipolar in vivo recordings of directional electrode pairs. Then, time delay information was used to detect the wavefront direction. The algorithm was verified using synthetic data and validated using experimental data. Ten high-resolution in vivo slow wave signals from 5 pigs were recorded for a duration of 2 minutes. The performance was compared against the semi-automated approach, resulting in an average angle error of 20° for the experimental data. The algorithm was able to detect slow wave wavefront orientation with minimal errors rapidly.Clinical relevance-The ability to rapidly detect slow wave propagation direction will enable effective analysis of large data sets, through which we can obtain a better understanding of functional motility disorders and help with diagnosis and treatment.


Assuntos
Transtorno Bipolar , Estômago , Algoritmos , Animais , Transtorno Bipolar/diagnóstico , Eletrodos , Reprodução , Suínos
17.
J Affect Disord ; 276: 623-625, 2020 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-32871694

RESUMO

BACKGROUND: The 2019-nCov pandemic is currently a stressor for the general public worldwide. In China, people who have a history of contact with infected or suspected individuals need to quarantine for at least 2 weeks. Many people experienced anxiety, panic and depression in the quarantine period. However, acute manic episode triggered by stressful events is not common and was neglected. CASE PRESENTATION: A 32-year-old woman with direct contact history with her infected colleagues showed elevated mood and increased activity when she was identified negative of nuclear acid amplification test, after experiencing extreme stress in quarantine. She was diagnosed with acute manic episode finally. The social zeitgeber and reward hypersensitivity theoretical models have attempted to use psychobiological perspectives to determine why life stress can trigger a mood episode, including (hypo)mania. Besides, the temporal correlation between her somatic symptoms and psychological stimuli indicated a possibility of functional disturbance under acute stress. CONCLUSION: Quarantine is a major stressful event disrupting social zeitgebers for people who have had contact with infected individuals, especially for vulnerable individuals with a hypersensitive reward system. Stress could act as a trigger in the onset of manic episode, so psychological support should be more targeted at the vulnerable individuals in the initial phase of emergent crisis.


Assuntos
Betacoronavirus , Transtorno Bipolar , Infecções por Coronavirus , Pandemias , Pneumonia Viral , Adulto , Transtorno Bipolar/psicologia , Feminino , Humanos , Quarentena , Estresse Psicológico
18.
Artigo em Inglês | MEDLINE | ID: mdl-32942345

RESUMO

Background: There is a paucity of studies on treatment of childhood-onset bipolar disorder and its associated comorbidities, which leads to a wide diversity of opinion on choice and sequencing of treatment options. Methods: From December 2018 to January 2019, a graphic depiction of medications and weekly ratings of symptoms of mania, depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), and oppositional behavior that parents had rated on their 9-year-old child over a period of several years was sent to experts in child and adult bipolar disorder. These responding medical doctors (MDs, 8 child and 18 adult psychiatrists) rated a comprehensive list of medications that they would choose (and with what priority) to treat the child's now improved mood (mania and depression) but continued mild to moderate symptoms of anxiety, ADHD, and oppositional behavior. Results: In the whole group, the drugs most highly endorsed were lamotrigine: 69%, lithium: 62%, lurasidone: 62%, quetiapine: 54%, aripiprazole: 46%, and valproate: 42%. Among the antidepressants, 38% endorsed a selective serotonin reuptake inhibitor, 12% a serotonin-norepinephrine reuptake inhibitor, and 27% bupropion. Of the child MDs, 75% suggested increasing the 1-mg dose of risperidone, while few adult MDs suggested this. Conversely, 56% of the adult MDs suggested using valproate, while only 1 child MD did so. There was little consensus on how to manage ADHD symptoms unresponsive to methylphenidate 36 mg/d. How these treatment options were sequenced also varied widely. Conclusions: There was wide variation in suggestions on to how to treat persistent symptoms of anxiety, ADHD, and oppositional behavior in a child whose mania and depression had been brought under good control. We surmise that this great diversity in recommendations among experts in child and adult bipolar disorder stems at least partially from inadequate literature on treatment and that a new emphasis on funding and conducting studies on efficacy and effectiveness is needed.


Assuntos
Transtornos de Ansiedade/tratamento farmacológico , Transtornos de Deficit da Atenção e do Comportamento Disruptivo/tratamento farmacológico , Transtorno Bipolar/tratamento farmacológico , Psicotrópicos/uso terapêutico , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Transtorno Bipolar/terapia , Criança , Consenso , Feminino , Humanos , Prevenção Primária , Indução de Remissão
19.
Artigo em Inglês | MEDLINE | ID: mdl-32942346

RESUMO

Introduction: Bipolar disorder is a complex mood disorder characterized by a chronic and subtle course of fluctuating manic/hypomanic and depressive symptoms. Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist with serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. Post hoc analyses evaluated efficacy across symptoms in bipolar depression. Methods: Pooled data were analyzed from 3 phase 2 or 3, randomized, double-blind, placebo-controlled studies of adults with bipolar disorder and a major depressive episode. Mean change from baseline to week 6 in Montgomery-Asberg Depression Rating Scale (MADRS) total score and individual item scores were analyzed in individual dose groups (1.5 mg/d, 3 mg/d) and overall cariprazine (1.5-3 mg/d). Pooled safety was evaluated via adverse events. Results: A significantly greater difference in mean change from baseline in MADRS total score was seen for each cariprazine dose group versus placebo (least squares mean difference vs placebo: 1.5-3 mg/d = -2.6, 1.5 mg/d = -2.8, 3 mg/d = -2.4) (P < .001 all). Significant differences versus placebo were seen on all individual MADRS items except inner tension for the overall cariprazine group (P < .05). Cariprazine was generally well tolerated. Conclusions: Cariprazine demonstrated broad efficacy across symptoms of depression in bipolar disorder. In previous post hoc analyses, cariprazine also demonstrated broad efficacy across manic symptoms, suggesting that it is effective across the wide range of symptoms on the bipolar spectrum. A 1.5-mg/d starting dose and slow titration resulted in lower rates of some adverse events in the bipolar depression studies versus the mania studies. Trial Registration: ClinicalTrials.gov identifiers: NCT01396447, NCT02670538, NCT02670551.


Assuntos
Transtorno Bipolar/tratamento farmacológico , Transtorno Depressivo Maior/tratamento farmacológico , Neurotransmissores/farmacologia , Piperazinas/farmacologia , Adulto , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neurotransmissores/administração & dosagem , Neurotransmissores/efeitos adversos , Piperazinas/administração & dosagem , Piperazinas/efeitos adversos , Resultado do Tratamento
20.
Rev Med Suisse ; 16(707): 1745-1747, 2020 Sep 23.
Artigo em Francês | MEDLINE | ID: mdl-32969610

RESUMO

Circadian rhythmicity generated by the biological clock structures the functioning of human beings over a period of almost 24 hours. This clock is entrained daily by internal and external cues among which light is the most powerful. Several disturbances, whether clinical or biological, observed in bipolar disorders are suggestive of a disruption of the circadian rhythm. Thus, treatments that modulate the biological clock have been developed. So far, the results of light therapy are not unanimous and invite us to better specify the treatment modalities. Dark therapy is a promising intervention that is still not much studied nowadays and therefore opens up great prospects for research in the future.


Assuntos
Transtorno Bipolar/psicologia , Escuridão , Luz , Fotoperíodo , Relógios Biológicos/efeitos da radiação , Ritmo Circadiano/efeitos da radiação , Humanos
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