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1.
Wei Sheng Yan Jiu ; 48(4): 577-582, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31601338

RESUMO

OBJECTIVE: To investigate the correlation between the polymorphisms of(brain derived neurotrophic factor, BDNF)BDNF gene rs11030104 and rs2030324 and executive function in children with attention deficit hyperactivity disorder(ADHD). METHODS: A total of 206 ADHD children and 212 control children were enrolled in the study. Five mL peripheral venous blood was extracted from each subject and genomic DNA was extracted. The genotypes of rs11030104 and rs2030324 loci were genotyped by PCR/sequencing. The selection was tested by Wisconsin Classification Card Test, Stroop Color-Word Task, Reaction/Nonresponse Task and Stop Signal Task. RESULTS: The distribution of rs2030324 locus gene frequency was different between ADHD group and control group. G allele was the risk factor of ADHD(χ~2=4. 481, P=0. 034; OR=1. 520, 95%CI 1. 031-2. 243); rs11030101 locus gene frequency distribution and genotype distribution had statistical significance between the two groups, and A allele was related to ADHD susceptibility(OR=1. 601, 95%CI 1. 052-2. 436). The error interference score of Stroop test in ADHD group was higher than that in control group(P<0. 05), but there was no significant difference in response time interference score between the two groups(P>0. 05). The SCWT scores of different genotypes of BDNF rs2030324 in ADHD group were different. Compared with AA type and AG type, the SCWT error interference scores of GG type ADHD patients were higher. There was no significant difference among rs11030101 genotypes. The WCST scores of ADHD group were lower than those of control group. The variation of Go/no-go scores in ADHD group was higher than that of control group in missed count, mistaken count and correct reaction time. The variation of SST and correct reaction time in ADHD group were higher than that of control group, but the genotype distribution of rs11030104 and rs2030324 loci had no significant correlation with WCST, Go/no-go and SST scores. CONCLUSION: Children with ADHD have executive dysfunction. ADHD children with BDNF rs2030324 GG genotype showed poor Stroop executive function.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/genética , Fator Neurotrófico Derivado do Encéfalo/genética , Criança , Função Executiva , Frequência do Gene , Humanos , Polimorfismo de Nucleotídeo Único
2.
Medicina (B Aires) ; 79 Suppl 3: 33-36, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31603841

RESUMO

The development and establishment of the normal sleep patterns are very important processes in the final anatomical and physiological architecture of the central nervous system. The relationship between sleep disturbances during childhood with neurodevelopmental disorders is complex and potentially synergistic. Sleep patterns are present since the fetal period but their structure and physiology is modified according with the maturation of the central nervous system. Sleep disorders and their relationship with attention deficit hyperactivity disorders(ADHD), autism spectrum disorders(ASD) and other neurodevelopmental disorders (TDN) are not well understood yet, but significant progresses have been made in understanding associations and potential etiological correlations. We reviewed sleep disturbances in NDT, in ADHD and in ASD. A greater understanding of the pleiotropic functions of the genes involved in sleepwake cycle disorders and deviations from neurological developme nt could lead to new diagnostic and therapeut ic strategies in an early stage in order to improve the quality of life of the patient, relatives and caregivers.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/complicações , Transtorno do Espectro Autista/complicações , Transtornos do Sono-Vigília/complicações , Transtorno do Deficit de Atenção com Hiperatividade/genética , Transtorno do Espectro Autista/genética , Pré-Escolar , Ritmo Circadiano , Humanos , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/genética
3.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46811

RESUMO

In many ways, ADHD and executive functioning issues go hand in hand. That’s because most of the symptoms of ADHD (also known as ADD) are actually problems with executive function. (You’ll see the signs of each are very similar!) There’s one big difference between the two, however.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Função Executiva
4.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46812

RESUMO

Attention deficit hyperactivity disorder (ADHD) is a behavioural disorder that includes symptoms such as inattentiveness, hyperactivity and impulsiveness.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade
5.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46813

RESUMO

O Transtorno do Déficit de Atenção com Hiperatividade (TDAH) é um transtorno neurobiológico, de causas genéticas, que aparece na infância e freqüentemente acompanha o indivíduo por toda a sua vida. Ele se caracteriza por sintomas de desatenção, inquietude e impulsividade. Ele é chamado às vezes de DDA (Distúrbio do Déficit de Atenção). Em inglês, também é chamado de ADD, ADHD ou de AD/HD.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade
6.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46814

RESUMO

Our mission is to educate, guide and inspire parents of children with learning disabilities or ADHD. Our aim is to help parents realize their children’s significant gifts and talents, and to show that with their love, guidance, and the right support, their children can live happy and productive lives.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Dislexia , Comunicação não Verbal , Função Executiva
7.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46806

RESUMO

O DPAC é caracterizado por afetar as vias centrais da audição, ou seja, as áreas do cérebro relacionadas às habilidades auditivas responsáveis por um conjunto de processos que vão da detecção à interpretação das informações sonoras. Na maior parte dos casos, o sistema auditivo periférico (tímpano, ossículos, cóclea e nervo auditivo) encontra-se totalmente preservado. A principal consequência do distúrbio está na dificuldade de processamento das informações captadas pelas vias auditivas. Assim, a pessoa ouvirá claramente a fala humana, mas terá dificuldades em interpretar a mensagem recebida.


Assuntos
Córtex Auditivo , Audição , Transtorno do Deficit de Atenção com Hiperatividade , Síndrome de Asperger
8.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46807

RESUMO

Up to twelve percent of children have diagnosed or undiagnosed auditory processing disorder, a condition that inhibits the brain’s ability to translate and process sounds. Learn more about common signs and symptoms.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Transtornos da Percepção Auditiva
9.
Stud Health Technol Inform ; 267: 3-8, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31483248

RESUMO

Differential item functioning (DIF) indicates differential response probabilities of items for different subgroups. While there is a vast amount of research and literature on DIF in the field of educational screening and career assessment, DIF analysis has hardly been applied in the field of clinical assessment. This paper aims at analyzing the presence of gender related DIF in a cross-sectional survey of children assessed by a structured questionnaire containing items on attention deficit and hyperactivity. A total of 1449 children (mean age: 1.94 ± 0.14 years; 51.2% male) were included. Almost no significant variations in parameters were found between boys and girls. Results based on a Partial Credit Model indicate an absence of DIF in eight out of nine items. Consistent with other studies in attention deficit hyperactivity disorder (ADHD) our results imply that the same level of rating for a symptom has the same meaning for boys and girls.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Inquéritos e Questionários
10.
Psychiatr Danub ; 31(Suppl 3): 265-275, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31488739

RESUMO

BACKGROUND: Neurostimulation techniques are potential methods of treating ADHD, involving stimulation of brain areas showing abnormal activity in ADHD. They are associated with benefits that last longer with fewer side effects. This literature review will evaluate the effectiveness of these methods. SUBJECTS AND METHODS: A literature search using scientific databases including PubMed and the Cochrane Library, using "ADHD" and "Attention Deficit Hyperactivity Disorder" combined with "Transcranial Magnetic Stimulation", "TMS", "Transcranial Direct Current Stimulation", "tDCS", "Vagus Nerve Stimulation", "VNS", "Trigeminal Nerve Stimulation", "TNS", "Deep Brain Stimulation", "DBS", "Electroconvulsive Therapy", "ECT", "Ultrasound stimulation" as keywords was conducted, yielding 417 references, 30 of which are used in this paper. RESULTS: Mixed results have been found in the effectiveness of neurostimulatory methods in treating ADHD. CONCLUSIONS: Neurostimulation techniques have potential in treating ADHD, with some studies having positive results. More research using greater sample sizes and standardised outcome measures could be done to verify the results of previous studies.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/terapia , Estimulação Encefálica Profunda , Eletroconvulsoterapia , Estimulação Transcraniana por Corrente Contínua , Estimulação Magnética Transcraniana , Estimulação do Nervo Vago , Humanos
11.
Dev Neuropsychol ; 44(6): 468-480, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31539285

RESUMO

Children with ADHD and ASD may present differences in the affective-motivational processes. We systematically review the literature regarding temporal discounting in children up to 12 years with ADHD and ASD. Six articles were included, five studies with ADHD children (n = 231), one with ASD children (n = 21), all including typically developing children as controls (n = 210). Five studies (four with ADHD and one with ASD) found greater temporal reward discounting for clinical groups. Occurrence of ADHD appears to rush even more the decision-making process at this stage of development, but there is still a lack in the literature, especially evaluating individuals with ASD.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Transtorno do Espectro Autista/psicologia , Comportamento de Escolha/fisiologia , Desvalorização pelo Atraso , Recompensa , Criança , Feminino , Humanos , Masculino
12.
Niger J Clin Pract ; 22(9): 1241-1251, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31489861

RESUMO

Background: One of the most common neurodevelopmental problems affecting behavior of children all over the world is attention deficit hyperactivity disorder (ADHD). Studies on ADHD prevalence in Africa used either parents' or teachers' disruptive behavioral disorder rating scale (DBDRS) to diagnose ADHD, but this study diagnose ADHD using both parents and teachers DBDRS simultaneously among primary school pupils in Ile-Ife. Materials and Methods: The study was conducted among 1,385 primary school pupils in Ile-Ife using multistage random sampling. The parents' and teachers' DBDRS were used simultaneously to screen children who had ADHD. Results: Sixty-five (4.7%) of the pupils had ADHD. Among the 65 pupils with ADHD, 28 (43%) had the inattentive subtype, 25 (38.5%) had the combined subtype, whereas 12 (18.5%) had hyperactive/impulsive subtype. The prevalence of ADHD was significantly higher in the younger age group than the older age groups (χ2 = 7.153, P = 0.007). There was no significant association found between the prevalence of ADHD and the social class (χ2 = 3.852, P = 0.146). Conclusion: ADHD prevalence of 4.7% was found among the children in Ile-Ife. Assessment of children for ADHD was done by parents at home and teachers in the school with DBDRS. The inattentive subtype was the most common and the hyperactive subtype was the least seen in the study. Early diagnosis and treatment of this disorder will bring better outcome in the children.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Nigéria/epidemiologia , Pais , Prevalência , Instituições Acadêmicas , Classe Social
13.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(7. Vyp. 2): 58-66, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31532592

RESUMO

The authors review current data on the role of the synthetic aspartic acid analogue N-acetyaspartate (NAA) in various biochemical metabolic reactions in the CNS. Its importance as a biomarker for neuropsychiatric disorders identified using magnetic resonance spectroscopy (MRS) is noted. The authors present their own results of the use of cogitum, a synthetic analogue of NAA, in children with the effects of traumatic brain injury, mental retardation, hyperactivity disorder and in the complex therapy of schizotypal disorder. Effects of cogitum on cognitive deficit, asthenia are evaluated. The neurotrophic effect of the drug, which specifically affects cognitive and asthenic disorders in these diseases, is shown.


Assuntos
Ácido Aspártico , Transtorno do Deficit de Atenção com Hiperatividade , Ácido Aspártico/uso terapêutico , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Encéfalo , Criança , Colina , Creatina , Humanos , Espectroscopia de Ressonância Magnética , Neurologia/tendências , Psiquiatria/tendências
14.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-LISBR1.1-46746

RESUMO

Nem sempre os pais levam a sério quando escutam que o filho não se concentra na sala de aula. Mas você sabia que isso pode ser Transtorno do Déficit de Atenção com Hiperatividade (TDAH)? Esse transtorno é neurobiológico, de causas genéticas, que aparece na infância e frequentemente acompanha o indivíduo por toda a sua vida e se caracteriza por sintomas de desatenção, inquietude e impulsividade


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Criança
15.
Nervenarzt ; 90(9): 926-931, 2019 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-31407043

RESUMO

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common comorbidity in adult patients with substance use disorders (SUDs). The diagnostics and treatment of ADHD with SUD are often a challenge, also with respect to the prescription of stimulants. Recently, a group of international experts developed a consensus paper on the diagnosis and treatment of comorbid ADHD and SUD. In addition, the German S3 guidelines on ADHD have been published, which also give advice on the treatment of ADHD in comorbid SUD. The German S3 guidelines on alcohol-related disorders and methamphetamine-related disorders also address ADHD as a comorbidity. METHODS: Summary of consensus and guideline recommendations, supplemented with the most recent literature. CONCLUSION: In recent years new findings on the comorbidity of ADHD in patients with SUD have emerged. A series of screening and diagnostic instruments have meanwhile been evaluated in this patient group. The consensus paper and various guidelines therefore provide clinicians with specific help in detecting ADHD in patients with SUD and in conducting further diagnostics and treatment of both disorders. For example, the importance of stimulants in the treatment of patients with SUD and ADHD has significantly changed and first studies on psychotherapeutic interventions specific to this comorbidity are now available.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Estimulantes do Sistema Nervoso Central , Transtornos Relacionados ao Uso de Substâncias , Transtorno do Deficit de Atenção com Hiperatividade/complicações , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Estimulantes do Sistema Nervoso Central/administração & dosagem , Comorbidade , Alemanha , Humanos , Transtornos Relacionados ao Uso de Substâncias/complicações
16.
Stud Health Technol Inform ; 266: 156-161, 2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31397317

RESUMO

BACKGROUND: Digital Health Interventions (DHIs) can improve mental health literacy (MHL) and help-seeking behaviour in teens and adults. However, it is unclear whether DHIs improve parental MHL, help-seeking behaviour or access to mental health services for their children. OBJECTIVE: To perform a scoping review of DHIs aiming to improve MHL, help-seeking behaviour or access to mental health services among parents of 2-12-year-olds with behavioural and emotional problems (BEP). METHOD: A search of Ovid MEDLINE found four original articles meeting inclusion criteria. RESULTS: One of the four articles was a randomised controlled trial, which showed a significant improvement in some measures of MHL, but no change in help-seeking attitudes. The other three studies evaluated interventions, in uncontrolled pre-test and post-test evaluations, on attention-deficit/hyperactivity disorder knowledge. Two of these studies showed a significant change in ADHD knowledge. There was no consistency in MHL measures between studies. CONCLUSIONS: There is preliminary evidence that DHIs may improve MHL in parents of children with BEP. How this translates to help seeking, access to mental health services or improved outcomes is unknown.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Alfabetização em Saúde , Serviços de Saúde Mental , Adolescente , Criança , Pré-Escolar , Humanos , Saúde Mental , Pais
17.
Postgrad Med ; 131(7): 445-452, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31443616

RESUMO

Given the complexity of neurocutaneous syndromes, a multidisciplinary approach has been advocated in order to provide optimum care. Subjects and Methods: Retrospective analysis of a cohort of 157 patients during a 3-year period, seen at a newly developed neurocutaneous clinic in a pediatric tertiary care hospital in Athens (Greece); and systematic chart review of the patients diagnosed with neurofibromatosis type 1 during this time period. Results: The most frequent neurocutaneous syndromes were neurofibromatosis type 1 (NF1) in 89 patients and tuberous sclerosis complex in 17. In 20.38% of patients a neurocutaneous syndrome was not confirmed. Approximately 2/3 of the NF1 patients underwent genetic analysis, and for 76.67% of them, a pathogenic mutation on the NF1 gene was revealed. Eighty-one patients manifested with generalized NF1 and eight with mosaic NF1. Dermatological manifestations included café-au-lait macules in all patients, followed by axillary and/or inguinal freckling (n = 57), external plexiform neurofibromas (n = 17), and cutaneous and subcutaneous neurofibromas (n = 11). Approximately half of patients had learning disabilities and attention deficit hyperactivity disorder, followed by mental retardation (n = 9), autistic spectrum disorders (n = 4), headaches (n = 3) and seizures (n = 2). Neuroimaging showed characteristic areas of hyperintensity on T2-weighted images in 74.07% of patients and optic pathway glioma in 19.75%. Two patients developed malignant peripheral sheath nerve tumor. Conclusions: Neurocutaneous syndromes are clinically heterogeneous and the surveillance of potential clinical complications is challenging. The availability of genetic diagnosis and novel imaging methods in this group of disorders is likely to further expand their clinical spectrum. Guidelines for assessment and management will need to be modified based on new available data.


Assuntos
Neurofibromatose 1/fisiopatologia , Equipe de Assistência ao Paciente , Esclerose Tuberosa/fisiopatologia , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/complicações , Transtorno do Espectro Autista/complicações , Manchas Café com Leite/complicações , Criança , Pré-Escolar , Estudos de Coortes , Dermatologistas , Feminino , Genes da Neurofibromatose 1 , Testes Genéticos , Genética Médica , Grécia , Humanos , Lactente , Deficiência Intelectual/complicações , Transtornos de Aprendizagem/complicações , Masculino , Mosaicismo , Síndromes Neurocutâneas/genética , Síndromes Neurocutâneas/fisiopatologia , Síndromes Neurocutâneas/terapia , Neurofibroma Plexiforme/complicações , Neurofibromatose 1/complicações , Neurofibromatose 1/genética , Neurofibromatose 1/terapia , Neurologistas , Neuropsicologia , Oncologistas , Oftalmologistas , Cirurgiões Ortopédicos , Ambulatório Hospitalar , Pediatras , Radiologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/fisiopatologia , Neoplasias Cutâneas/terapia , Esclerose Tuberosa/complicações , Esclerose Tuberosa/genética , Esclerose Tuberosa/terapia
20.
Tijdschr Psychiatr ; 61(7): 477-487, 2019.
Artigo em Holandês | MEDLINE | ID: mdl-31372969

RESUMO

BACKGROUND: Substance use disorders (SUD) and attention-deficit/hyperactivity disorder (ADHD) often co-occur in adults. Together, they complicate diagnosis and can negatively influence treatment outcome.
AIM: To develop a practical guide to assist professionals with the screening, diagnosis and treatment of adult patients with SUD and ADHD.
METHOD: A literature search and a consensus procedure between several international scientific and clinical experts. This manuscript is an adapted and summarized Dutch version of the International consensus statement on screening, diagnosis and treatment of patients with SUD and comorbid ADHD.
RESULTS: The routine use of adequate screening tools enables ADHD to be detected earlier in adults with SUD. The diagnostic process for ADHD should be initiated as soon as possible in patients with SUD. Integrated treatment, involving a combination of pharmacotherapy and psychotherapy, is preferred. Long-acting stimulants with up-titration to higher dosages may be considered.
CONCLUSION: Early detection of ADHD in patients with SUD is essential for adequate diagnosis and more effective treatment and follow-up for these patients.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Transtorno do Deficit de Atenção com Hiperatividade/terapia , Transtornos Relacionados ao Uso de Substâncias/diagnóstico , Transtornos Relacionados ao Uso de Substâncias/terapia , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Comorbidade , Consenso , Humanos , Programas de Rastreamento , Transtornos Relacionados ao Uso de Substâncias/epidemiologia
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