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1.
Soins Psychiatr ; 40(324): 33-36, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31623805

RESUMO

Transcultural consultations receive unaccompanied minors experiencing psychological distress as a result of their personal history in their country of origin, their harrowing journey until their arrival in France and their vulnerable situation. Presentation of the mental health pathway and identity issues of one of these young unaccompanied foreigners, and asylum seeker.


Assuntos
Criança Abandonada/psicologia , Menores de Idade/psicologia , Transtornos Psicóticos/terapia , Refugiados/psicologia , Estresse Psicológico/psicologia , Adolescente , Criança , Características Culturais , França , Humanos , Psicoterapia
2.
Psychiatr Danub ; 31(3): 355-357, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31596829

RESUMO

We aimed to compare processing speed (PS) and its subcomponents in schizophrenia (SC) and schizoaffective disorder (SA). Thirty-five patients were divided into two groups (SC=18; SA=17). PS tasks from the MATRICS Consensus Cognitive Battery Central/South America version were used. Additional PS subcomponents were analyzed (i.e., behavioral execution, response processing, and accuracy). SA obtained significant higher scores than SC in response processing, verbal fluency and the PS general domain. Our results indicate that PS is a potential cognitive marker to differentiate between SC and SA. Further research with larger samples must be conducted.


Assuntos
Transtornos Cognitivos/fisiopatologia , Transtornos Cognitivos/psicologia , Transtornos Psicóticos/fisiopatologia , Transtornos Psicóticos/psicologia , Esquizofrenia/fisiopatologia , Psicologia do Esquizofrênico , Transtornos Cognitivos/complicações , Humanos , Testes Neuropsicológicos , Projetos Piloto , Transtornos Psicóticos/complicações , Esquizofrenia/complicações
4.
Psychiatr Danub ; 31(Suppl 3): 338-344, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31488750

RESUMO

INTRODUCTION: Mental difficulties are common in the postpartum period. They can manifest in a mild form, but also as serious disorders which need to be treated in a timely manner. The most common psychological problem is "Baby blues" characterized by relatively short duration without consequences and treatment is largely unnecessary. Postpartum depression is characterized by a sense of sadness, loss of interest, insomnia, discomfort, loss of energy, reduced concentration. Postpartum psychosis is the most serious disorder but is also rare and may have serious consequences for the mother and child. Important factors in the postpartum mental problems/difficulties are genetic factors, situation of unwanted pregnancy, a feeling of discomfort with the role of motherhood and sudden hormonal changes. AIM: to investigate the frequency and type of mental problems in postpartum period, as well as possible type of help needed by the women in postpartum period. SUBJECTS AND METHODS: One hundred (112) respondents participated in the survey. The survey was conducted from November to December 2017 through a "google docs" application. The survey was placed on different social networks, and the participation in the survey was voluntary and anonymous. A series of 14 questions with the offered answers was used in the survey. RESULTS: The results of the survey have shown that psychological difficulties and disturbances in the postpartum period to be common problems encountered by almost 50% of women (44.46%). The most common difficulty is Baby blues, followed by postpartum depression and anxiety disorders. Age and the mode of birth did not affect the emergence of changes, while social factors such as family support had a great impact. CONCLUSION: The provision of information to the mothers can help, but inaccurate information can do the opposite. Thus, the role of health care professionals is important for helping mothers in that period to prevent certain difficulties as well as in identifying and referring mothers to seek help in a timely fashion.


Assuntos
Ansiedade/epidemiologia , Depressão Pós-Parto/epidemiologia , Depressão Pós-Parto/psicologia , Mães/psicologia , Período Pós-Parto/psicologia , Transtornos Psicóticos/epidemiologia , Ansiedade/psicologia , Criança , Feminino , Humanos , Recém-Nascido , Mães/educação , Gravidez , Gravidez não Desejada/psicologia , Transtornos Psicóticos/psicologia , Inquéritos e Questionários
5.
Psychiatr Danub ; 31(Suppl 3): 608-612, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31488799

RESUMO

Schizophrenic patients have traditionally suffered from high rates of cardiovascular disease and early mortality. NICE guidelines suggest that several physical health measures be monitored regularly in these patients, and particularly those on antipsychotic medication, which has a wide side-effect profile that may potentiate the risk of cardiovascular disease and other comorbidities. This general practice audit aimed to determine the rates of physical health monitoring in primary care in patients on antipsychotic medication for over a year for psychotic symptoms or schizophrenia. The search was conducted in three different general practices in March 2019, yielding 19, 8 and 30 patients respectively, with a total of 57 patients. This audit aims to record and analyse rates of monitoring of a range of physical health measures recommended by NICE guidelines over the past year. The results demonstrated that physical health monitoring was poor amongst all the practices audited, especially that of prolactin and waist circumference. We recommend that these rates of monitoring be improved, through implementing templates or the delivery of targeted education to general practitioners and nurses.


Assuntos
Antipsicóticos/efeitos adversos , Medicina Geral , Atenção Primária à Saúde , Transtornos Psicóticos/complicações , Transtornos Psicóticos/tratamento farmacológico , Esquizofrenia/complicações , Esquizofrenia/tratamento farmacológico , Antipsicóticos/administração & dosagem , Auditoria Clínica , Humanos , Transtornos Psicóticos/fisiopatologia , Esquizofrenia/fisiopatologia
7.
Internist (Berl) ; 60(11): 1209-1214, 2019 Nov.
Artigo em Alemão | MEDLINE | ID: mdl-31501912

RESUMO

BACKGROUND: Clozapine is an alternative antipsychotic medication used to control symptoms of schizophrenia and to reduce risks of suicidal behavior in patients who did not adequately respond to standard medication. Due to severe side effects including cardiomyopathy and myocarditis its clinical use is limited. CASE REPORT: A 31-year-old man of east European descent presented to the emergency medical department with fatigue, shortness of breath and chest pain. Due to a schizoaffective disorder he was treated with clozapine and lithium. Echocardiography revealed severely impaired left ventricular systolic function. After exclusion of coronary artery disease by coronary angiography an endomyocardial biopsy was performed according to the guidelines. This confirmed the clinically suspected toxic cardiomyopathy. Therefore, antipsychotic treatment was immediately changed and state of the art heart failure medication was started resulting in a clear improvement of left ventricular function. CONCLUSION: In patients treated with clozapine or lithium and clinical signs of heart failure, toxic cardiomyopathy should be considered.


Assuntos
Antipsicóticos/efeitos adversos , Cardiomiopatias/induzido quimicamente , Dor no Peito/etiologia , Clozapina/efeitos adversos , Dispneia/etiologia , Fadiga/etiologia , Transtornos Psicóticos/tratamento farmacológico , Adulto , Antipsicóticos/uso terapêutico , Biópsia , Clozapina/uso terapêutico , Ecocardiografia , Coração/diagnóstico por imagem , Humanos , Masculino , Miocárdio/patologia , Resultado do Tratamento
8.
Crim Behav Ment Health ; 29(4): 247-255, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31478306

RESUMO

BACKGROUND: Mentally disordered offenders may suffer discrimination on the basis of mental disorder, or on the basis of being offenders, or both. AIMS: The aim of this paper is to outline a framework for examining discrimination affecting mentally disordered offenders. It is argued that there should be systematic comparisons between offenders with mental disorder and nonoffenders with mental disorder in order to identify and characterise specific failures to ensure equivalence of mental health care; and systematic comparisons between offenders with mental disorder and offenders without mental disorder in order to identify how mental disorder may constitute a barrier to forms of support and constructive intervention available to other offenders. METHODS: A critical review was conducted of official documents presenting criminal justice and mental health policy for England and Wales, principally since 2012, together with reports of inspectorate and oversight bodies and relevant research studies. FINDINGS: There is evidence that offenders with mental disorder may not be able to access mental health care equivalent to that for nonoffenders with mental disorder. There is also evidence that they may not be able to access interventions available to other offenders. Further disadvantage may arise in the criminal courts since, in England and Wales, if inpatient care is required, the powers of criminal courts to effect hospital admission under Part III of mental health legislation are weakened by the statutory requirement of information that places are available. This is discriminatory against offenders with mental disorder insofar as forms of court disposal for other offenders are not prevented by the capacity of criminal justice agencies. CONCLUSIONS AND IMPLICATIONS: The review supports the need for systematic comparisons to identify forms of disadvantage and discrimination experienced by mentally disordered offenders in relation to both mental health and criminal justice policies services.


Assuntos
Direito Penal , Criminosos/psicologia , Discriminação (Psicologia) , Transtornos Mentais/psicologia , Serviços de Saúde Mental/legislação & jurisprudência , Saúde Mental/legislação & jurisprudência , Direito Penal/legislação & jurisprudência , Inglaterra , Hospitalização , Humanos , Transtornos Psicóticos , País de Gales
9.
Niger J Clin Pract ; 22(9): 1281-1285, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31489867

RESUMO

Background: The Medication Adherence Rating Scale (MARS) is a 10-item self-report measure of medication adherence in psychosis which is a vital predictor of illness course and outcome in patient with schizophrenia. The initial and subsequent studies have shown that MARS has good reliability and validity scores after correction for the small sample size in the index study. Aim: This study aimed to determine the psychometric properties of MARS among outpatients with schizophrenia at the outpatient clinic of the Neuropsychiatric Hospital Aro Abeokuta Ogun State Nigeria. Methods: Intra-class correlation coefficient (ICC) was used to determine the internal consistency, item-total correlations, and reliability of the instrument. Factor analysis was done using principal component analysis with varimax rotation. Results: The intra-class correlation coefficient (ICC) for these 10 items (at time T1) was 0.6 with a P value of <0.001 while for the test--retest analysis was 0.7 with a P value of 0.04. A principal components factor analysis with varimax rotation produced a four-factor solution and factor 4 was found to be the most internally consistent, with Cronbach's alpha of 0.63. Conclusion: This study supports the internal consistency, test--retest reliability, and constructs validity of the MARS.


Assuntos
Adesão à Medicação/psicologia , Adesão à Medicação/estatística & dados numéricos , Psicometria/instrumentação , Esquizofrenia/tratamento farmacológico , Inquéritos e Questionários/normas , Adulto , Análise Fatorial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Pacientes Ambulatoriais , Transtornos Psicóticos , Reprodutibilidade dos Testes , Esquizofrenia/diagnóstico , Autorrelato
10.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(7. Vyp. 2): 5-12, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31532585

RESUMO

OBJECTIVE: To analyze indicators of the referral rate for highly specialized inpatient psychiatric care in adolescents with psychotic disorders. MATERIAL AND METHODS: Clinical/dynamic and statistical methods were used to study the data of patients, aged 14-17 years, with psychotic mental disorders according to ICD-10, as well as the indicators of their hospitalization in psychiatric consulting and medical institution during the calendar year. RESULTS AND CONCLUSION: The analysis of 2017 data shows that 6.3% of hospitalized children and adolescents have a psychotic disorder, the vast majority (82.3%) of whom are adolescents, aged 14-17 years (149 patients, including 79 boys, 70 girls). Of 181 patients referred to the hospital with a diagnosis of a psychotic disorder, the preliminary diagnostic judgment was not confirmed during hospitalization in 30 (16.6%) patients, in the course of therapy in 24 (13.3%) cases. The prevalence of patients with endogenous psychoses (about 80% in the structure of schizophrenic process, schizoaffective, affective pathology), the prevalence of older adolescents, gender relations in psychotic disorders of different nosological nature are revealed.


Assuntos
Transtornos Psicóticos , Esquizofrenia , Adolescente , Criança , Feminino , Hospitalização , Humanos , Classificação Internacional de Doenças , Masculino , Prevalência , Transtornos Psicóticos/epidemiologia , Esquizofrenia/epidemiologia
12.
Psychiatr Prax ; 46(7): 376-380, 2019 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-31412369

RESUMO

OBJECTIVE: The pilot study aimed to apply and evaluate the German version of DIALOG+ in patients with psychosis. METHODS: The German version of DIALOG+ was used with ten patients with psychosis in five sessions each over a 8-week period. DIALOG+ is a brief intervention that is supported by an App, structures clinical routine consultations and helps patients to define and achieve personal goals. For evaluating outcomes, symptom levels, disability and subjective quality of life before and after treatment were compared. RESULTS: Adherence was high with a total of 49 of 50 planned sessions completed. Patients showed significant improvements in schizophrenia symptoms (d = 0.88), depressive symptoms (d = 0.85), everyday impairment (d = 0.83) and subjective quality of life (d = 0.12). CONCLUSION: The German version of DIALOG+ provides a feasible and promising approach to make routine meetings therapeutically effective.


Assuntos
Transtornos Psicóticos , Esquizofrenia , Alemanha , Humanos , Projetos Piloto , Transtornos Psicóticos/diagnóstico , Qualidade de Vida , Esquizofrenia/diagnóstico
13.
Stud Health Technol Inform ; 264: 418-422, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31437957

RESUMO

For patients with a diagnosis of schizophrenia, determining symptom onset is crucial for timely and successful intervention. In mental health records, information about early symptoms is often documented only in free text, and thus needs to be extracted to support clinical research. To achieve this, natural language processing (NLP) methods can be used. Development and evaluation of NLP systems requires manually annotated corpora. We present a corpus of mental health records annotated with temporal relations for psychosis symptoms. We propose a methodology for document selection and manual annotation to detect symptom onset information, and develop an annotated corpus. To assess the utility of the created corpus, we propose a pilot NLP system. To the best of our knowledge, this is the first temporally-annotated corpus tailored to a specific clinical use-case.


Assuntos
Processamento de Linguagem Natural , Transtornos Psicóticos , Registros Eletrônicos de Saúde , Humanos , Registros
14.
Rev Med Suisse ; 15(658): 1402-1406, 2019 Aug 14.
Artigo em Francês | MEDLINE | ID: mdl-31411831

RESUMO

In psychiatry, alternatives to hospitalisation have been developed further to deinstitutionalisation. With the decrease in the number of psychiatric beds and the emergence of new representations regarding the possibility of recovery for people with mental disorder, hospitalisations have been limited to crisis periods. Sheltered housing has been created for vulnerable people. New models of care such «â€…assertive ¼ community treatment ¼ allow to following people with severe mental disorders in the community, whilst avoiding precariousness and isolation. This article aims to present alternatives to psychiatric hospitalisation in a vision of care that answers patients' needs in a proportional and efficient way, that offers a good collaboration with other care providers and that is well-balanced between community care and hospitalisations.


Assuntos
Assistência Ambulatorial , Serviços Comunitários de Saúde Mental , Transtornos Mentais , Psiquiatria , Transtornos Psicóticos , Hospitalização , Humanos , Transtornos Mentais/terapia , Transtornos Psicóticos/terapia
15.
Psychiatr Danub ; 31(2): 162-171, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31291220

RESUMO

In this project, we recruited a sample of 150 patients with first episode of psychosis with schizophrenia features (FEP) and 100 healthy controls. We assessed the differences between these two groups, as well as the changes between the acute phase of illness and subsequent remission among patients over 18-month longitudinal follow-up. The assessments were divided into four work packages (WP): WP1- psychopathological status, neurocognitive functioning and emotional recognition; WP2- stress response measured by saliva cortisol during a stress paradigm; cerebral blood perfusion in the resting state (with single photon emission computed tomography (SPECT) and during activation paradigm (with Transcranial Ultrasonography Doppler (TCD); WP3-post mortem analysis in histologically prepared human cortical tissue of post mortem samples of subjects with schizophrenia in the region that synaptic alteration was suggested by WP1 and WP2; WP4- pharmacogenetic analysis (single gene polymorphisms and genome wide association study (GWAS). We expect that the analysis of these data will identify a set of markers that differentiate healthy controls from patients with FEP, and serve as an additional diagnostic tool in the first episode of psychosis, and prediction tool which can be then used to help tailoring individualized treatment options. In this paper, we describe the project protocol including aims and methods and provide a brief description of planned post mortem studies and pharmacogenetic analysis.


Assuntos
Biomarcadores/análise , Transtornos Psicóticos/genética , Feminino , Seguimentos , Estudo de Associação Genômica Ampla , Humanos , Hidrocortisona/análise , Masculino , Farmacogenética , Estudos Prospectivos , Transtornos Psicóticos/complicações , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/tratamento farmacológico , Saliva/química , Esquizofrenia/complicações
16.
Harefuah ; 158(7): 427-431, 2019 Jul.
Artigo em Hebraico | MEDLINE | ID: mdl-31339240

RESUMO

BACKGROUND: The Israel Mental Health Act of 1991 stipulates a process for involuntary psychiatric hospitalization (IPH). A patient thus hospitalized can be discharged by either the treating psychiatrist (TP) or the district psychiatric committee (DPC). The decision rendered by the DPC is often at odds with the recommendation of the TP. This study attempts to compare the variance between the TP and the DPC decisions in different geographical regions in Israel. METHODS: We examined the outcomes of decisions made by the DPC using readmission data - an internationally recognized indicator of the quality of hospital care - and compared them to the outcomes of patients discharged by the TP. All IPH discharges resulting from the DPC's determination for the year 2013 (N = 972) were taken from the Israel National Register. We also collected information regarding all IPH discharges owing to the TP's decision for 2013 (N = 5788). We defined "failure" as readmission in fewer than 30 days, involuntary civil readmission in fewer than 180 days, and involuntary readmission under court order in less than 1 year. RESULTS: The re-hospitalization pattern was compared in the two groups of patients discharged from psychiatric hospitalization during 2013 (index discharges) and followed up individually for a year. We found a statistically significant difference between the success rates of the various regional DPCs and the hospital TP groups, with the TP average (74.5% national success rate) success significantly better than the DPC groups (66.7% national success rate). Moreover, the variance between the decisions made in the different geographical regions in the two groups was also statistically significant (σ2 variance was 80.4 and 27.1 for the DPC and TP groups, respectively). CONCLUSIONS: The results we present indicate that the variance of decision "failure" (readmission) and "success" across the various geographical regions was found to be significantly better in the TP group than in the DPC group. We consider it likely that whereas TPs discharge IPH patients in accordance with well-accepted clinical approaches, the DPC's decisions are based on interpretations of the law (regarding, e.g., the patient posing a physical threat) and on the DPC's understanding of what is meant by the patient's "best interests." We suggest introducing more formal psychiatric training for the legal staff of the DPCs and building a structured and standardized method for reviewing the patient. Moreover, we propose using "soft paternalism" as an approach, which would justify limitations on individual liberties for the benefit of persons being restricted, provided that they are unable to make a choice that would be consistent with their own interests. This is often an appropriate and perhaps a more practical approach, one that the DPC could adopt in place of the present conservative approach, which requires a specific standard of "proof" of major illness to qualify as insanity requiring hospitalization.


Assuntos
Alta do Paciente , Transtornos Psicóticos , Tomada de Decisões , Hospitalização , Humanos , Israel
17.
Harefuah ; 158(7): 463-467, 2019 Jul.
Artigo em Hebraico | MEDLINE | ID: mdl-31339247

RESUMO

INTRODUCTION: In recent years, the importance of cultural sensitivity and the adaptation of mental health services to diverse populations has been growing. Simultaneously, awareness of psychiatric illnesses and treatment is increasing, even among the Haredi (ultra-orthodox) population in Israel, with specialized services developing. Many studies have emphasized the central role of religion and belief in the coping styles of those with mental illness and their healing processes. These characteristics are especially evident among the Haredi population, where religion is present in behavior, in thought, both within the individual and in the community, and throughout life. In the encounter between a religious Haredi patient and the professional, many issues arise regarding religion and the patient's socio-cultural affiliation. Being familiar with this world, including unique concepts and sensitivity to these issues, can promote treatment that is provided to ultra-orthodox individuals with mental-illness in a manner that is culturally sensitive. These issues include specific expressions and manifestations of psychiatric illness in the religious Haredi patient, and issues related to the specific Haredi community to which the patient belongs. Discussions in the literature and halakhic rulings are divided into issues concerning the patient, religious law observance by the patient with mental-illness, issues regarding treatment coercion, pregnancy, and issues relating to therapy, such as "privacy" and "life and death" dilemmas. Unique expressions of psychiatric disorders in the Haredi patient may be noted in eating disorders, psychosis and OCD, both in clinical terms and in prognosis and disease processes. Factors related to society and the ultra-orthodox community to which the psychiatric patient belongs include issues of stigma and secrecy that are maintained by the community in relation to mental illness; interference by non-professional individuals involved in treatment; as well as the distinctiveness of treatment and rehabilitation adapted to the Haredi population and finally cultural sensitivity to the needs of the religiously observant patient (such as avoiding desecration of Shabbat, rehabilitation in unique areas such as Torah study, etc.).


Assuntos
Psiquiatria , Transtornos Psicóticos , Feminino , Humanos , Israel , Judeus , Judaísmo , Gravidez
18.
Crim Behav Ment Health ; 29(3): 157-167, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31274230

RESUMO

BACKGROUND: Current Japanese forensic mental health legislation (Medical Treatment and Supervision Act [MTSA]) was enacted in 2003. Little is known, however, about the actual outcomes for the offender patients detained within hospitals under this provision. AIM: This study aimed to quantify reoffending and readmission following patients' discharge from forensic psychiatric hospital units across Japan and explore related risk factors. METHODS: We followed up 526 offenders with mental disorder who had been detained under the MTSA and who were subsequently discharged from any of the 28 hospitals nationwide between 2007 and 2015. RESULTS: The total cumulative reoffence rate was found to be 2.5% (1.1-3.9%) after 1 year and 7.5% (4.6-10.4%) after 3 years. The rate of serious reoffending was 0.4% (-0.18% to 0.99%) after 1 year and 2.0% (0.4-3.6%) after 3 years. The cumulative admission rate to local psychiatric hospitals following a discharge was 21.8% after 6 months and 37.6% after 1 year. Patients who had been discharged from their MTSA order but transferred to a general psychiatric hospital before open community residence-because it was necessary to build community supports-were more likely to reoffend than those discharged directly to the community. Patients who had been diagnosed with a substance use disorder (F10-F19) and had one subsequent admission were at higher risk of further readmissions. CONCLUSIONS: The low reoffending rates could be attributed to the intensive treatment and care plans required by the MTSA. The high rate of readmission to psychiatric hospitals may indicate shortcomings in community mental health services in Japan.


Assuntos
Criminosos , Hospitais Psiquiátricos/estatística & dados numéricos , Alta do Paciente , Readmissão do Paciente/estatística & dados numéricos , Transtornos Psicóticos/psicologia , Adulto , Serviços Comunitários de Saúde Mental , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de Substâncias/psicologia
19.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(4. Vyp. 2): 63-68, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31317917

RESUMO

Insomnia is one of the most common symptoms of mental pathology (affective, anxious, hypochondriac, asthenic, psychotic) and reveals a number of characteristic features depending on the structure of the mental disorder. Psychopharmacotherapy for insomnia in mental disorders is an important aspect of patient supervision. Doxylamine (donormil) is one of the promising drugs for the correction of insomnia, both in combination with other psychotropic drugs and in monotherapy.


Assuntos
Transtornos Mentais , Transtornos Psicóticos , Distúrbios do Início e da Manutenção do Sono , Ansiedade , Doxilamina , Humanos , Psicotrópicos
20.
Autoimmun Rev ; 18(9): 102348, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31323365

RESUMO

Psychotic disorders are debilitating mental illnesses associated with abnormalities in various neurotransmitter systems. The development of disease-modifing therapies has been hampered by the mostly unknown etiologies and pathophysiologies. Autoantibodies against several neuronal antigens are responsible for autoimmune encephalitis. These autoantibodies disrupt neurotransmission within the brain, resulting in a wide range of psychiatric and neurologic manifestations, including psychosis. The overlap of symptoms of autoimmune encephalitis with psychotic disorders raised the question as to whether autoantibodies against a number of receptors, ion channel and associated proteins could ultimately be responsible for some forms of psychosis. Here we review our current knowledge, on antibody mediated autoimmunity in psychotic disorders, the different diagnostic methods and their limitations, as well as on varying therapeutic approaches targeting the immune system.


Assuntos
Autoimunidade/fisiologia , Testes Imunológicos/tendências , Imunoterapia/tendências , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/imunologia , Transtornos Psicóticos/terapia , Autoanticorpos/análise , Autoanticorpos/sangue , Autoanticorpos/imunologia , Encéfalo/fisiologia , Encefalite/diagnóstico , Encefalite/imunologia , Encefalite/terapia , Doença de Hashimoto/diagnóstico , Doença de Hashimoto/imunologia , Doença de Hashimoto/terapia , Humanos , Sistema Imunitário/fisiologia , Testes Imunológicos/métodos , Imunoterapia/métodos , Terapia de Alvo Molecular/métodos , Terapia de Alvo Molecular/tendências , Neurônios/imunologia , Neurônios/patologia
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