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2.
PLoS One ; 15(9): e0238389, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32898166

RESUMO

Mapping brain functions is crucial for neurosurgical planning in patients with drug-resistant seizures. However, presurgical language mapping using either functional or structural networks can be challenging, especially in children. In fact, most of the evidence on this topic derives from cross-sectional or retrospective studies in adults submitted to anterior temporal lobectomy. In this prospective study, we used fMRI and DTI to explore patterns of language representation, their predictors and impact on cognitive performances in 29 children and young adults (mean age at surgery: 14.6 ± 4.5 years) with focal lesional epilepsy. In 20 of them, we also assessed the influence of epilepsy surgery on language lateralization. All patients were consecutively enrolled at a single epilepsy surgery center between 2009 and 2015 and assessed with preoperative structural and functional 3T brain MRI during three language tasks: Word Generation (WG), Rhyme Generation (RG) and a comprehension task. We also acquired DTI data on arcuate fasciculus in 24 patients. We first assessed patterns of language representation (relationship of activations with the epileptogenic lesion and Laterality Index (LI)) and then hypothesized a causal model to test whether selected clinical variables would influence the patterns of language representation and the ensuing impact of the latter on cognitive performances. Twenty out of 29 patients also underwent postoperative language fMRI. We analyzed possible changes of fMRI and DTI LIs and their clinical predictors. Preoperatively, we found atypical language lateralization in four patients during WG task, in one patient during RG task and in seven patients during the comprehension task. Diffuse interictal EEG abnormalities predicted a more atypical language representation on fMRI (p = 0.012), which in turn correlated with lower attention (p = 0.036) and IQ/GDQ scores (p = 0.014). Postoperative language reorganization implied shifting towards atypical language representation. Abnormal postoperative EEG (p = 0.003) and surgical failures (p = 0.015) were associated with more atypical language lateralization, in turn correlating with worsened fluency. Neither preoperative asymmetry nor postoperative DTI LI changes in the arcuate fasciculus were observed. Focal lesional epilepsy associated with diffuse EEG abnormalities may favor atypical language lateralization and worse cognitive performances, which are potentially reversible after successful surgery.


Assuntos
Mapeamento Encefálico , Epilepsias Parciais/diagnóstico por imagem , Epilepsias Parciais/psicologia , Transtornos da Linguagem/diagnóstico por imagem , Transtornos da Linguagem/psicologia , Adolescente , Criança , Cognição , Compreensão , Imagem de Tensor de Difusão , Epilepsia Resistente a Medicamentos/diagnóstico por imagem , Epilepsia Resistente a Medicamentos/psicologia , Epilepsia Resistente a Medicamentos/cirurgia , Epilepsias Parciais/cirurgia , Feminino , Lateralidade Funcional , Neuroimagem Funcional , Humanos , Imagem por Ressonância Magnética , Masculino , Estudos Prospectivos , Adulto Jovem
3.
Cogn Behav Neurol ; 33(3): 192-200, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32889951

RESUMO

BACKGROUND: It is estimated that ∼30% of stroke survivors have aphasia, a language disorder resulting from damage to left-hemisphere language networks. In acute care settings, efficient identification of aphasia is critical, but there is a paucity of efficient bedside assessments. OBJECTIVE: To determine whether objective measures on a picture description task administered within 48 hours post stroke (a) predict language recovery, (b) estimate left-hemisphere lesion volume and location, and (c) correlate with other bedside language assessments. METHOD: Behavioral data were scored at acute and chronic time points. Neuroimaging data were used to determine associations between the picture description task, other language assessments, and lesion volume and location. RESULTS: Acute content units, age, and total lesion volume predicted communication recovery; F3,18 = 3.98, P = 0.024; r = 0.40. Significant correlations were found between the picture description task and lesion volume and location. Picture description outcomes were also associated with other clinical language assessments. DISCUSSION: This picture description task quickly predicted the language performance (communication recovery and outcome) for patients who suffered a left-hemisphere stroke. Picture description task measures correlated with damage in the left hemisphere and with other, more time-consuming and cumbersome language assessments that are typically administered acutely at bedside. CONCLUSION: The predictive value of this picture description task and correlations with existing language assessments substantiate the clinical importance of a reliable yet rapid bedside measure for acute stroke patients that can be administered by a variety of health care professionals.


Assuntos
Afasia/etiologia , Transtornos da Linguagem/etiologia , Acidente Vascular Cerebral/complicações , Afasia/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Acidente Vascular Cerebral/mortalidade , Análise de Sobrevida
4.
Yonsei Med J ; 61(8): 726-730, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32734737

RESUMO

Language disorganization, an objective component of formal thought process abnormality, has been regarded as a core symptom of schizophrenia from an evolutionary psychopathology perspective. However, to the best of our knowledge, the network structure of language disorganization has rarely been examined in patients with schizophrenia. Thus, our preliminary study aimed to evaluate the network structure using the Clinical Language Disorder Rating Scale (CLANG) in 167 inpatients with schizophrenia. All 17 of the CLANG items were considered to be ordered categorical variables ranging from 0 to 3. Our results indicated that disclosure failure, excess syntactic constraints, abnormal prosody, and aprosodic speech rank among the top five central domains within the network structure. We deemed that disclosure failure and prosody problems are the most important symptoms of language disorder in schizophrenia. Thus, reduced top-down processing of linguistic information may be a core neurobiological underpinning of language disorganization in schizophrenia. Further studies controlling for the potential effects of confounding factors (i.e., duration of illness) on network analyses of language disorder and formal thought disorder are warranted in patients with schizophrenia.


Assuntos
Transtornos da Linguagem/complicações , Transtornos da Linguagem/psicologia , Esquizofrenia/complicações , Psicologia do Esquizofrênico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
5.
Int J Pediatr Otorhinolaryngol ; 138: 110262, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32705994

RESUMO

Recently, a novel virus has spread worldwide causing the disease called COVID-19. In addition to putting people's lives at risk and causing mortality, various problems have occurred due to the negative effects of the COVID-19 pandemic. Quarantine, social distancing, and the obligation to use protective tools have led to sometimes long term closing of various jobs and services, including rehabilitation services. For instance, the disease has interrupted the provision of Speech-Language Pathology (SLP) services to children due to the need for face-to-face communication between Speech and Language Pathologists (SLPs) and children during the evaluation and treatment processes. Therefore, here, we described the quality of providing SLP services during the COVID-19 pandemic and the negative effects of the disease on the provision of SLP services. In addition, we made an attempt to explain concerns and problems raised by the families, the importance of providing SLP services during the critical period of speech and language development, telepractice services, the roles of speech-language-hearing related scientific associations, and the roles of SLPs during the outbreak of COVID-19.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Transtornos da Linguagem/terapia , Pandemias , Pneumonia Viral , Patologia da Fala e Linguagem , Criança , Comunicação , Transtornos da Comunicação , Humanos , Fala
6.
Codas ; 32(3): e20190058, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32609224

RESUMO

PURPOSE: Identify factors related to the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY) representing more than one category and verify their association with sociodemographic and health care aspects in a speech-language pathology (SLP) outpatient clinic. METHOD: This is an observational, analytical, cross-sectional study based on a retrospective analysis of secondary data. One hundred eighty medical records of patients aged 5-16 years evaluated between 2010 and 2014 were included in the study. Sociodemographic and health care aspects were identified in these records, as well as presence of the ICF-CY Body Functions and Activities and Participation component categories. Analyses of the frequency distribution and measures of central tendency and dispersion of the variables, as well as Factor Analysis were carried out to create representative indicators of the ICF-CY categories identified. The Mann-Whitney and Kruskal-Wallis tests and the Spearman's correlation were used to analyze the associations, adopting a statistical significance level of 5%. RESULTS: Two factors that presented statistically relevant associations with the sociodemographic and health care variables were identified for the Body Functions component. As for the Activities and Participation component, three factors predominantly associated with the health care variables were identified. CONCLUSION: Items representative of the ICF-CY Body Functions and Activities and Participation categories and their respective factorial loads were identified. Statistically significant associations were verified between them and the sociodemographic and health care variables analyzed.


Assuntos
Atividades Cotidianas , Classificação Internacional de Funcionalidade, Incapacidade e Saúde , Transtornos da Linguagem , Distúrbios da Fala , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Avaliação da Deficiência , Humanos , Transtornos da Linguagem/diagnóstico , Estudos Retrospectivos , Fala , Distúrbios da Fala/diagnóstico
7.
Neurology ; 95(6): e718-e732, 2020 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-32518148

RESUMO

OBJECTIVE: To characterize the extent of CNS involvement in children with Pompe disease using brain MRI and developmental assessments. METHODS: The study included 14 children (ages 6-18 years) with infantile Pompe disease (IPD) (n = 12) or late-onset Pompe disease (LOPD) (n = 2) receiving enzyme replacement therapy. White matter (WM) hyperintense foci seen in the brain MRIs were systematically quantified using the Fazekas scale (FS) grading system with a novel approach: the individual FS scores from 10 anatomical areas were summed to yield a total FS score (range absent [0] to severe [30]) for each child. The FS scores were compared to developmental assessments of cognition and language obtained during the same time period. RESULTS: Mild to severe WM hyperintense foci were seen in 10/12 children with IPD (median age 10.6 years) with total FS scores ranging from 2 to 23. Periventricular, subcortical, and deep WM were involved. WM hyperintense foci were seen throughout the path of the corticospinal tracts in the brain in children with IPD. Two children with IPD had no WM hyperintense foci. Children with IPD had relative weaknesses in processing speed, fluid reasoning, visual perception, and receptive vocabulary. The 2 children with LOPD had no WM hyperintense foci, and high scores on most developmental assessments. CONCLUSION: This study systematically characterized WM hyperintense foci in children with IPD, which could serve as a benchmark for longitudinal follow-up of WM abnormalities in patients with Pompe disease and other known neurodegenerative disorders or leukodystrophies in children.


Assuntos
Encefalopatias Metabólicas Congênitas/diagnóstico por imagem , Encéfalo/diagnóstico por imagem , Deficiências do Desenvolvimento/diagnóstico por imagem , Doença de Depósito de Glicogênio Tipo II/diagnóstico por imagem , Imagem por Ressonância Magnética , Neuroimagem , Adolescente , Idade de Início , Encéfalo/patologia , Encefalopatias Metabólicas Congênitas/etiologia , Criança , Transtornos Cognitivos/diagnóstico por imagem , Transtornos Cognitivos/etiologia , Estudos Transversais , Deficiências do Desenvolvimento/etiologia , Terapia de Reposição de Enzimas , Glucana 1,4-alfa-Glucosidase/uso terapêutico , Doença de Depósito de Glicogênio Tipo II/complicações , Doença de Depósito de Glicogênio Tipo II/tratamento farmacológico , Doença de Depósito de Glicogênio Tipo II/psicologia , Humanos , Transtornos da Linguagem/diagnóstico por imagem , Transtornos da Linguagem/etiologia , Imagem por Ressonância Magnética/métodos , Neuroimagem/métodos , Substância Branca/diagnóstico por imagem
8.
BMC Health Serv Res ; 20(1): 385, 2020 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-32375752

RESUMO

BACKGROUND: To improve the uptake of research into practice, knowledge translation frameworks recommend tailoring implementation strategies to address practice barriers. This study reports our experience pairing the Theoretical Domains Framework with information from multiple stakeholder groups to co-develop practice-informed strategies for improving the implementation of an evidence-based outcome measurement tool across a large community health system for preschoolers with communication impairments. METHODS: Concept mapping was used to identify strategies for improving implementation of the Focus on the Outcomes of Communication Under Six (FOCUS) in Ontario Canada's Preschool Speech and Language Program. This work was done in five stages. First, we interviewed 37 speech-language pathologists (clinicians) who identified 90 unique strategies to resolve practice barriers to FOCUS implementation. Second, clinicians (n = 34), policy-makers (n = 3), and members of the FOCUS research team (n = 6) sorted and rated the strategies by importance and feasibility. Third, stakeholders' sorting data were analyzed to generate a two-dimensional concept map. Based on the rating data from stakeholders, we prioritized a list of strategies that were rated as highly important and highly feasible, and summarized the practice barriers addressed by each of the prioritized strategies. Fourth, we validated these findings with stakeholders via an online survey. Fifth, the mechanisms of action of the prioritized list of strategies were considered based on available evidence from the Theoretical Domains Framework and associated behavior change literature. RESULTS: Stakeholders categorized the 90 unique implementation strategies into a six-cluster concept map. Based on stakeholders' ratings, a list of 14 implementation strategies were prioritized. These implementation strategies were reported to resolve barriers within the environmental context and resources and beliefs about consequences domains of the Theoretical Domains Framework. All but one of the prioritized strategies have a demonstrated link in resolving existing barriers according to the behavioral change literature. CONCLUSIONS: Our study contributes to a growing literature that demonstrates the process of tailoring implementation strategies to specific barriers. Practical drawbacks and benefits of using concept mapping as a way to engage stakeholders in implementation research are discussed.


Assuntos
Prática Clínica Baseada em Evidências/organização & administração , Ciência da Implementação , Pré-Escolar , Humanos , Transtornos da Linguagem/terapia , Ontário , Distúrbios da Fala/terapia , Patologia da Fala e Linguagem , Participação dos Interessados , Inquéritos e Questionários
9.
PLoS One ; 15(5): e0233349, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32469951

RESUMO

BACKGROUND: Numerous studies have noted the presence of a dysexecutive component of the ALS-FTD. The most widely replicated result refers to the significantly reduced verbal fluency of ALS patients when compared to healthy people. As ALS patients have motor alterations that interfere with production, qualitative studies have the advantage of being independent of the degree of motor disability and revealing patients' cognitive state. This study examined the production differences between 42 ALS patients who presented with different degrees of dementia and motor impairment and 42 healthy people. Production processes were studied by extending the administration time of a letter fluency task to 2 minutes for the phonemic verbal fluency (PVF) and semantic verbal fluency (SVF) categories. This ensured that the qualitative aspects of verbal fluency were addressed, paying special attention to the new perseverations and intrusions, as well as any clinical correlates that may exist. RESULTS: The ALS patients produced a significantly lower number of responses in PVF (p = .017) and SVF (p = .008). The rest of the indicators for frontal lobe alteration also suggested the existence of a dysfunction. The most remarkable results were the number of intrusions on the PVF task, which was much higher in the ALS group (p = .002). However, the number of perseverations did not differ significantly. CONCLUSIONS: This study highlights the value of intrusions in addressing cognitive deterioration in ALS patients. This deterioration seems to be independent of the degree of motor impairment and of behavioural alterations. Therefore, the value of the intromissions on the verbal fluency task was highlighted as an indicator of a new cognitive alteration, which can be easily evaluated, even retrospectively.


Assuntos
Esclerose Amiotrófica Lateral/fisiopatologia , Transtornos Cognitivos/epidemiologia , Transtornos da Linguagem/epidemiologia , Transtornos Motores/epidemiologia , Semântica , Comportamento Verbal , Estudos de Casos e Controles , Criança , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Espanha/epidemiologia
11.
Clinics (Sao Paulo) ; 75: e1426, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32294668

RESUMO

OBJECTIVES: To compare the diagnostic accuracy of a low-cost screening test for identifying children at risk for language disorders with that of a specific language assessment. METHODS: The study was conducted during a polio vaccination campaign in basic health units in western São Paulo, Brazil. The parents/guardians of 1000 children aged between 0 and 5 years were asked to answer questions of a specific screening test. The instrument consisted of a uniform set of questions about the main milestones in language development (from 0 to 5 years of age) with scaled scores to assess responses. There were no exclusion criteria. After the screening test, the children were referred to a specific language assessment by ABFW, following a determined flow of referrals. The results obtained in the screening were compared to those obtained in the specific language assessment; then, the sensitivity, specificity, accuracy, and positive and negative predictive values were determined for the screening test. Children who failed the screening test also underwent an audiological evaluation. The statistical significance was set at 5%. RESULTS: The majority of the participants were aged between 4 and 5 years (21.82%) and were male (51.6%). The sensitivity and specificity values were 82.5% and 98.93%, respectively. The area under the curve was 0.907 (0.887-0.925), and the screening test showed 96% accuracy. CONCLUSIONS: The screening test showed high diagnostic efficiency in determining the risk of language disorders in children aged between 0 and 5 years.


Assuntos
Transtornos da Linguagem/diagnóstico , Programas de Rastreamento/métodos , Brasil , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Programas de Rastreamento/normas , Atenção Primária à Saúde , Encaminhamento e Consulta , Fatores de Risco , Sensibilidade e Especificidade
12.
Neurology ; 94(13): e1353-e1364, 2020 03 31.
Artigo em Inglês | MEDLINE | ID: mdl-32001514

RESUMO

OBJECTIVES: Alzheimer disease (AD) shows a broad array of clinical presentations, but the mechanisms underlying these phenotypic variants remain elusive. Aging-related astrogliopathy (ARTAG) is a relatively recent term encompassing a broad array of tau deposition in astroglia outside the range of traditional tauopathies. White matter thorn-shaped astrocyte (WM-TSA) clusters, a specific ARTAG subtype, has been associated with atypical language presentation of AD in a small study lacking replication. To interrogate the impact of WM-TSA in modifying clinical phenotype in AD, we investigated a clinicopathologic sample of 83 persons with pure cortical AD pathology and heterogeneous clinical presentations. METHODS: We mapped WM-TSA presence and density throughout cortical areas and interrogated whether WM-TSA correlated with atypical AD presentation or worse performance in neuropsychological testing. RESULTS: WM-TSA was present in nearly half of the cases and equally distributed in typical and atypical AD presentations. Worsening language and visuospatial functions were correlated with higher WM-TSA density in language-related and visuospatial-related regions, respectively. These findings were unrelated to regional neurofibrillary tangle burden. Next, unsupervised clustering divided the participants into 2 groups: a high-WM-TSA (n = 9) and low-WM-TSA (n = 74) pathology signature. The high-WM-TSA group scored significantly worse in language but not in other cognitive domains. CONCLUSIONS: The negative impact of WM-TSA pathology to language and possibly visuospatial networks suggests that WM-TSA is not as benign as other ARTAG types and may be explored as a framework to understand the mechanisms and impact of astrocytic tau deposition in AD in humans.


Assuntos
Doença de Alzheimer/patologia , Astrócitos/patologia , Transtornos da Linguagem/etiologia , Comportamento Espacial/fisiologia , Substância Branca/patologia , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/complicações , Encéfalo/patologia , Estudos Transversais , Feminino , Humanos , Transtornos da Linguagem/patologia , Masculino , Pessoa de Meia-Idade , Fenótipo
13.
Codas ; 32(1): e20180156, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32049151

RESUMO

PURPOSE: To develop a Speech-language Pathology (SLP) program and verify its effects on the reading comprehension of dyslexic students. METHODS: Participants were eleven 4th and 5th-grade Elementary School students, eight boys and three girls, aged 9-11 years, diagnosed with developmental dyslexia. All individuals underwent the therapeutic program, which was composed of 16 sessions divided into four levels of complexity. A text adapted according to the Cloze technique and reading comprehension and orthography tasks were used in each session. The schoolchildren had their reading comprehension assessed pre- and post-program using a text available at the Test of Reading Comprehension of Expository Texts, adapted for application of the structural Cloze technique without support, according to the Evaluation of Reading Comprehension Levels. RESULTS: The participants showed better performance in reading comprehension at the post-program assessment not only in the filling of blanks in the text adapted according to the Cloze technique and in the Responses to Reading Comprehension Questions, but also in the level of reading comprehension achieved. CONCLUSION: The SLP program improved the reading comprehension performance and increased motivation to reading of dyslexic schoolchildren. Both the Cloze technique and the Reading Comprehension Questions were useful tools to develop and identify changes in the reading comprehension of the students assessed. This study is relevant because it prepared and verified the effects of a specific remediation program for schoolchildren with dyslexia by proposing the use of texts adapted according to the Cloze technique combined with other various tasks of reading comprehension and orthography.


Assuntos
Compreensão , Dislexia/reabilitação , Transtornos da Linguagem/reabilitação , Leitura , Distúrbios da Fala/reabilitação , Criança , Feminino , Humanos , Transtornos da Linguagem/diagnóstico , Testes de Linguagem , Masculino , Distúrbios da Fala/diagnóstico , Estudantes
14.
World Neurosurg ; 136: 390-393.e3, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32004743

RESUMO

BACKGROUND: The thalamus has a demonstrated role in language, particularly through its connectivity to frontal language cortices. CASE DESCRIPTION: A 59-year-old man with transient mixed aphasia following resection of a left-sided thalamic cavernous malformation is reported. No operative complications were encountered, and there was no surgical contact with cortical language areas. The patient recovered full language function within a week postoperatively. CONCLUSIONS: The role of thalamic nuclei in language processes and other reports of transient thalamic aphasia are reviewed.


Assuntos
Afasia/etiologia , Hemangioma Cavernoso do Sistema Nervoso Central/cirurgia , Complicações Pós-Operatórias/etiologia , Tálamo/cirurgia , Hemangioma Cavernoso do Sistema Nervoso Central/diagnóstico por imagem , Humanos , Idioma , Transtornos da Linguagem/etiologia , Transtornos da Linguagem/psicologia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Recuperação de Função Fisiológica , Tálamo/anormalidades , Tálamo/diagnóstico por imagem , Resultado do Tratamento
15.
Fisioter. Pesqui. (Online) ; 27(1): 41-47, jan.-mar. 2020. tab
Artigo em Português | LILACS | ID: biblio-1090407

RESUMO

RESUMO As cardiopatias congênitas (CC) estão entre as principais causas de morbimortalidade na primeira infância e os lactentes com essa condição podem apresentar atrasos no desenvolvimento neuropsicomotor (DNPM). O objetivo deste estudo foi avaliar a influência da CC no DNPM de lactentes. Trata-se de um estudo observacional com avaliação do desenvolvimento neuropsicomotor realizada pela Bayley Scales of Infant and Toddler Development (BSID-III). As condições maternas e clínicas dos lactentes foram verificadas no relatório de alta médica e na caderneta de saúde da criança, e a condição socioeconômica das famílias pelo Critério da Classificação Econômica Brasil. Para associar as variáveis clínicas e o DNPM foram utilizados o coeficiente de correlação de Spearman e o teste de razão de verossimilhança. Foram avaliados 18 lactentes, com predomínio do sexo feminino (72,2%). A maioria das mães (47,1%) possuía ensino médio completo ou superior incompleto, com média da idade de 27,2±5,5 anos. Houve correlação das escalas do BSID-III com as variáveis quantitativas analisadas: escala motora com o peso (p=0,02 e r=0,54) e com uso de oxigenoterapia (p=0,009 e r=−0,591); já para as variáveis qualitativas as associações foram entre: escala motora e condição socioeconômica (p=0,015), escala motora e comunicação interatrial - (CIA) (p=0,023) e escala da linguagem e CIA (p=0,038). A CC influenciou o DNPM, principalmente no aspecto motor. Além disso peso, diagnóstico de CIA, uso de oxigenoterapia e condição socioeconômica foram considerados como principais fatores de risco para o atraso no DNPM.


RESUMEN Las cardiopatías congénitas (CC) se encuentran entre las principales causas de morbimortalidad en la primera infancia, y los lactantes con esta afección pueden tener retrasos en el desarrollo neuropsicomotor (DNPM). El presente estudio tuvo el objetivo de evaluar la influencia de las CC en el DNPM de los lactantes. Este es un estudio observacional en el cual se evaluó el desarrollo neuropsicomotor utilizando la Bayley scales of infant and toddler development (BSID-III). Las condiciones maternas y clínicas de los lactantes se obtuvieron en el informe de alta médica y en la libreta de salud del niño, y el estado socioeconómico de las familias en el Criterio de Clasificación Económica de Brasil. Para asociar las variables clínicas y el DNPM, se utilizaron el coeficiente de correlación de Spearman y la prueba de razón de probabilidad. Se evaluaron a 18 lactantes, con un predominio del sexo femenino (72,2%). La mayoría de las madres (47,1%) tenían la secundaria completa o la educación superior incompleta, con una edad promedio de 27,2±5,5 años. Hubo una correlación entre las escalas BSID-III y las variables cuantitativas analizadas: escala motora con el peso (p=0,02 y r=0,54) y con el uso de oxigenoterapia (p=0,009 y r=−0,591); para las variables cualitativas, las asociaciones fueron entre: escala motora y estado socioeconómico (p=0,015), escala motora y comunicación interauricular (CIA) (p=0,023) y escala de lenguaje y CIA (p=0,038). Las CC influyeron en el DNPM, principalmente en el aspecto motor. Además, el peso, el diagnóstico de CIA, el uso de oxigenoterapia y el estado socioeconómico fueron considerados los principales factores de riesgo para el retraso en el DNPM.


ABSTRACT Congenital heart defects (CHD) are among the main causes of morbidity and mortality in infants who has this impairment may present delays in neuropsychomotor development (NPMD). This study assesses the influence of CHD on NPMD of infants. This is an observational study assessing neuropsychomotor development performed by Bayley Scales of Infant and Toddler Development - BSID-III. The Brazilian Economic Classification Criteria was used to verify the socioeconomic status of the families and also the maternal and infants' clinical conditions were verified in the medical discharge report and in the child's health handbook. For the association between the quantitative and qualitative variables with the NPMD, the Spearman's correlation coefficient and the likelihood ratio test were used. A total of 18 infants were assessed, with a predominance of females (72.2%). Most mothers (47.1%) had complete high school or incomplete higher education, with a mean age of 27.2±5.5 years. There was a correlation between the BSID-III scales and the quantitative variables analyzed: motor scale with weight (p=0.02 and r=0.54) and oxygen therapy (p=0.009 and r=−0.591); besides that, the qualitative variables correlation were: motor scale and socioeconomic condition (p=0.015), motor scale and Interatrial Communication - IAC (p=0.023) and language with IAC scales (p=0.038). CHD influences the delay of NPMD, mainly for motor aspect. Furthermore, weight, diagnosis of IAC, use of oxygen therapy and socioeconomic status were considered the main risk factors for the delay in NPMD.


Assuntos
Humanos , Lactente , Transtornos Psicomotores/etiologia , Transtornos das Habilidades Motoras/etiologia , Transtornos do Neurodesenvolvimento/etiologia , Cardiopatias Congênitas/complicações , Oxigenoterapia/efeitos adversos , Transtornos Psicomotores/diagnóstico , Fatores Socioeconômicos , Desenvolvimento Infantil/fisiologia , Estudos Transversais , Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Transtornos das Habilidades Motoras/diagnóstico , Transtornos do Neurodesenvolvimento/diagnóstico , Hospitalização , Transtornos da Linguagem/diagnóstico , Transtornos da Linguagem/etiologia , Tempo de Internação , Testes Neuropsicológicos
16.
J Fluency Disord ; 63: 105745, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31889560

RESUMO

PURPOSE: The present study employed nonword repetition and nonword identification tasks to explore the phonological working memory (PWM) abilities and its interaction with speech motor control in school-aged children who do and do not stutter. METHOD: Participants were 17 children who stutter (CWS) (Age range = 7-12) and 17 age and gender-matched children who do not stutter (CWNS). For the nonword repetition task, the participants repeated sets of 2-, 3-, and 4-syllable nonwords (n = 12 per set). The participants silently identified a target nonword from a subsequent set of three nonwords (n = 12 per 2-, 3- and 4-syllable length) for the nonword identification task. The performance of CWS on the nonword repetition task was compared with the CWNS for the mean number of accurate repetitions, number of trials taken, number of accurate repetitions on initial trial, and number of fluent repetitions across the three-syllable conditions for the tasks. For the nonword identification task, the number of nonwords identified accurately by the two groups were subjected to analysis. RESULTS: CWS were significantly less accurate on the initial production of nonwords and required significantly more number of attempts to repeat the nonword accurately. Further for the nonword identification task, CWS were significantly less accurate than CWNS in correctly identifying the target nonword. CONCLUSIONS: The present findings suggest that, in addition to limitations in PWM capacity, an unstable speech motor control system in CWS may lead to dysfluent speech.


Assuntos
Memória de Curto Prazo/fisiologia , Fala/fisiologia , Gagueira/fisiopatologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Humanos , Idioma , Transtornos da Linguagem , Testes de Linguagem , Linguística , Masculino , Tempo de Reação , Medida da Produção da Fala , Comportamento Verbal
17.
Brain Lang ; 200: 104710, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31739187

RESUMO

This study used voxel-based lesion-symptom mapping to examine the cortical and white matter regions associated with language production impairments in a sample of 63 preoperative tumour patients. We identified four cognitive functions considered crucial for spoken language production: semantic-to-lexical mapping (selecting the appropriate lexical label for the intended concept); phonological encoding (retrieving the word's phonological form); articulatory-motor planning (programming the articulatory motor movements); and goal-driven language selection (exerting top-down control over the words selected for production). Each participant received a score estimating their competence on each function. We then mapped the region(s) where pathology was significantly associated with low scores. For semantic-to-lexical mapping, the critical map encompassed portions of the left posterior middle and inferior temporal gyri, extending into posterior fusiform gyrus, overlapping substantially with the territory of the inferior longitudinal fasciculus. For phonological encoding, the map encompassed the left inferior parietal lobe and posterior middle temporal gyrus, overlapping with the territory of the inferior longitudinal and posterior arcuate fasciculi. For articulatory-motor planning, the map encompassed parts of the left frontal pole, frontal operculum, and inferior frontal gyrus, and overlapped with the territory of the frontal aslant tract. Finally, the map for goal-driven language selection encompassed the left frontal pole and the anterior cingulate cortex. We compare our findings with those from other neuropsychological samples, and conclude that the study of tumour patients offers evidence that complements that available from other populations.


Assuntos
Mapeamento Encefálico , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/fisiopatologia , Transtornos da Linguagem/patologia , Transtornos da Linguagem/fisiopatologia , Fala/fisiologia , Adolescente , Adulto , Idoso , Neoplasias Encefálicas/complicações , Feminino , Lobo Frontal/patologia , Lobo Frontal/fisiopatologia , Humanos , Transtornos da Linguagem/complicações , Masculino , Pessoa de Meia-Idade , Semântica , Lobo Temporal/patologia , Lobo Temporal/fisiopatologia , Substância Branca/patologia , Substância Branca/fisiopatologia , Adulto Jovem
18.
J Autism Dev Disord ; 50(1): 278-291, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31621021

RESUMO

Comprehensive interventions for children with autism spectrum disorder (ASD) often incorporate augmentative and alternative communication (AAC); however, variability in outcomes exists even among children who access similar intervention. This study investigated predictors of expressive language change for 48 children with ASD aged 31 to 67 months receiving AAC-infused intervention. The relationships between participants' initial responses to AAC and expressive language change were examined. Commonly reported predictors (IQ, chronological age, ASD symptomatology) did not significantly predict expressive language change. AAC factors (visual attention, object play, word learning) entered at Step 2 of a hierarchical multiple regression, explained an additional 42% of the variance. The findings provide preliminary data on child characteristics associated with expressive language changes within AAC-infused comprehensive interventions.


Assuntos
Transtorno do Espectro Autista/terapia , Linguagem Infantil , Transtornos da Linguagem/terapia , Terapia da Linguagem/métodos , Transtorno do Espectro Autista/psicologia , Criança , Pré-Escolar , Feminino , Humanos , Transtornos da Linguagem/psicologia , Masculino , Análise Multivariada , Resultado do Tratamento , Aprendizagem Verbal
19.
Codas ; 32(1): e20170097, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-31851208

RESUMO

PURPOSE: To verify the access to speech-language pathology (SLP) therapy and continuity of assistance in Primary Health Care (PHC) for victims of motorcycle accidents. METHODS: A quantitative and qualitative study was conducted at a large hospital in the city of Recife, Pernanbuco state, Brazil. Among the 99 victims recruited between June and July 2014, 30 had SLP complaints as a result of the accidents. After hospital discharge, all victims were contacted for investigation of the SLP rehabilitation process. Absolute and relative frequencies were used for the analysis in PHC, and data were displayed in tables for the therapy cases. RESULTS: Among the 30 individuals who reported having alterations of the stomatognathic system, eight were undergoing rehabilitation and 18 reported residing in an area covered by the Family Health Strategy (primary care modality). Seeking and obtaining continuity of treatment (medication and bandaging) in primary care were frequent; in contrast, home visits were less frequent. The main obstacles to access SLP therapy were distance to the service and waiting time to begin treatment. CONCLUSION: This study identified obstacles that hamper access to SLP therapy in PHC, such as the low frequency of home visits, contributing to the fragmentation of continuous and complete care for victims.


Assuntos
Acidentes de Trânsito , Transtornos de Deglutição/reabilitação , Acesso aos Serviços de Saúde/estatística & dados numéricos , Transtornos da Linguagem/reabilitação , Motocicletas , Atenção Primária à Saúde , Adulto , Brasil , Estudos Transversais , Transtornos de Deglutição/epidemiologia , Transtornos de Deglutição/etiologia , Feminino , Humanos , Transtornos da Linguagem/epidemiologia , Transtornos da Linguagem/etiologia , Masculino , Pessoa de Meia-Idade , Adulto Jovem
20.
Eur J Paediatr Neurol ; 25: 139-144, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31866100

RESUMO

AIMS: Results from a previous study indicated that children with Rolandic epilepsy (RE) exhibit abnormalities of oromotor and dichotic listening performance. The current study aimed to investigate whether the same individuals, 10 years later, still exhibited differences between the groups. Earlier literature suggests that children with RE normalize after remission and as they become adults. More recent studies have, on the contrary, suggested that there is a risk for residual oromotor and language deficits after remission. METHODS: Eleven young adults with RE and 9 matched controls were retested 10 years after participating in a study investigating oromotor ability, articulation, dichotic listening ability, and phonological and semantic word retrieval. RESULTS: Results of this longitudinal study indicated that there was a persistent, albeit reduced, difference between the groups, after remission, in dichotic listening and, to some extent, oromotor performance. Articulation and word retrieval did not differ between the groups. CONCLUSION: Young adults with previous RE in childhood have a moderate risk for persistent difficulties in verbal perception and oromotor performance.


Assuntos
Epilepsia Rolândica/complicações , Transtornos da Linguagem/etiologia , Distúrbios da Fala/etiologia , Adolescente , Criança , Testes com Listas de Dissílabos , Feminino , Seguimentos , Humanos , Transtornos da Linguagem/epidemiologia , Estudos Longitudinais , Masculino , Distúrbios da Fala/epidemiologia , Adulto Jovem
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