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1.
Medicine (Baltimore) ; 99(45): e23033, 2020 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-33157955

RESUMO

INTRODUCTION: Microdeletion syndromes occur from deletion of 5Mb of a chromosome in approximately 5% of patients with unexplained intellectual disability. Interstitial microdeletions at bands 1p33 and 1p32.2 of the short arm of chromosome 1 are rare and have not been previously reported in relation to disease. PATIENT CONCERNS: We present a case of a 39-month boy with Pierre Robin sequence, development delay/intellectual disability, growth retardation, short stature, leukoencephalopathy, craniofacial dysplasia, and speech delay. The child was referred to the Child health care department in October 2014 for his delayed language development and aggravated aggression. DIAGNOSIS: Molecular diagnostic testing with G-band karyotyping was normal but clinical microarray analysis detected a 10 Mb microdeletion at 1p33p32.2. INTERVENTIONS: The patient received rehabilitation. OUTCOMES: Three candidate genes were pinpointed to the deleted area, including ORC1, SCP2, and DAB1. Phenotype-genotype analysis suggested that these three genes are likely to be responsible for the main phenotypes observed in the patient, such as microcephaly, growth retardation, short stature, leukoencephalopathy, and development delay/intellectual disability. CONCLUSIONS: The spectrum of phenotypes this case presented with are likely to be caused by 1p33p32.2 deletion which could represent a new microdeletion syndrome.


Assuntos
Cariotipagem/métodos , Análise em Microsséries/métodos , Síndrome de Pierre Robin/diagnóstico , Síndrome de Pierre Robin/genética , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/genética , Proteínas Adaptadoras de Transdução de Sinal/genética , Adolescente , Adulto , Proteínas de Transporte/genética , Criança , Pré-Escolar , Deleção Cromossômica , Anormalidades Craniofaciais/diagnóstico , Anormalidades Craniofaciais/genética , Nanismo/diagnóstico , Nanismo/genética , Feminino , Humanos , Lactente , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/genética , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/genética , Leucoencefalopatias/diagnóstico , Leucoencefalopatias/genética , Masculino , Microcefalia/diagnóstico , Microcefalia/genética , Proteínas do Tecido Nervoso/genética , Complexo de Reconhecimento de Origem/genética , Fenótipo , Síndrome de Pierre Robin/reabilitação
2.
Yonsei Med J ; 61(10): 880-890, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32975063

RESUMO

PURPOSE: The aim of this study was to investigate differences in language ability and emotional-behavioral problems according to the severity of social communication impairments (SCI) and restricted and repetitive behaviors (RRB) in children with autism spectrum disorders (ASD). MATERIALS AND METHODS: We grouped 113 children with ASD aged 3-12 years according to the severity of SCI and RRB, and investigated language differences and emotional-behavioral problems among the severity groups. If differences in language abilities between the groups were observed, they were further subdivided to examine possible predictors of both receptive and expressive language abilities. RESULTS: In cluster analyses using subdomains of the Autism Diagnostic Interview-revised, severe SCI individuals showed lower language ability than their milder counterparts, while RRB showed no differences. Receptive and expressive language in the severe SCI group was negatively predicted by social communication and social motivation, respectively. The severe RRB group showed significantly higher levels of anxiety/distress, somatic complaints, thought problems, attention problems, and aggressive behavior, while the severe SCI group was reported to be more withdrawn. CONCLUSION: The results of this study suggest that the severity of SCI greatly affects language ability. In children with severe SCI, social communication and social motivation negatively predicted receptive language and expressive language, respectively. Children with severe RRB may have more emotional-behavioral problems that require active intervention.


Assuntos
Sintomas Afetivos/diagnóstico , Sintomas Afetivos/psicologia , Transtorno do Espectro Autista/psicologia , Transtornos do Comportamento Infantil/diagnóstico , Transtornos do Comportamento Infantil/psicologia , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/psicologia , Desenvolvimento da Linguagem , Sintomas Afetivos/epidemiologia , Transtorno do Espectro Autista/diagnóstico , Transtorno do Espectro Autista/epidemiologia , Criança , Transtornos do Comportamento Infantil/epidemiologia , Pré-Escolar , Emoções , Feminino , Humanos , Idioma , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Masculino , Comportamento Problema , Índice de Gravidade de Doença
3.
PLoS One ; 15(5): e0232839, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32384118

RESUMO

BACKGROUND/OBJECTIVE: The effects of otitis media on the function of the central auditory nervous system in different populations is unknown. Understanding how the history of otitis media affects children from different nations will guide health professionals worldwide on the importance of adequate auditory stimulus in childhood. For this reason, the aim of the present study was to investigate the long-term auditory effects of middle ear disease on temporal processing and P300 in two different populations of children: Australian and Brazilian. METHODS: Temporal processing tests (Frequency Pattern Tests-FPT and Gaps in noise-GIN) and P300 were measured in 68 Brazilian and Australian children, aged between 8 to 14 years. The Brazilian otitis media group (BrOM) and Australian otitis media group (AusOM) consisted of 20 children each who had a documented history of otitis media. Control groups of 14 children (BrControl and AusControl) were also recruited from each country, all with no documented history of otitis media. RESULTS: The BrOM group showed significantly poorer performance (p<0.001) for FPT and the GIN compared to BrControl. The P300 response showed significantly longer mean latencies (p = 0.02) compared to BrControls. The AusOM group also showed significant delayed latency of P300 (p = 0.04) compared to the AusControl. The FPT showed significantly poorer performance (p = 0.04) compared to AusControls. The two otitis media groups showed no significant differences between each other on P300. Significant differences were seen however in temporal processing tests performance between the two cohorts for the otitis media groups. The BrOM group had significantly poorer responses (p<0.001) for FPT and GIN compared to the AusOM group. CONCLUSIONS: These findings support that although differences exist between BrOM and AusOM groups, otitis media can be demonstrated to affect the underlying mechanisms of the P300 measures and behavioral auditory responses in two different populations of children.


Assuntos
Potencial Evocado P300 , Transtornos do Desenvolvimento da Linguagem/etiologia , Otite Média com Derrame/fisiopatologia , Percepção do Tempo/fisiologia , Estimulação Acústica , Adolescente , Córtex Auditivo/fisiopatologia , Limiar Auditivo , Austrália , Brasil , Criança , Estudos Transversais , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/fisiopatologia , Transtornos do Desenvolvimento da Linguagem/psicologia , Masculino , Testes Neuropsicológicos , Otite Média com Derrame/psicologia , Desempenho Psicomotor , Recidiva , Estudos Retrospectivos , Tálamo/fisiopatologia
4.
Value Health ; 23(2): 164-170, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32113621

RESUMO

OBJECTIVES: To examine health-related quality of life (HRQoL) in young children with low language or congenital hearing loss and to explore the value of assessing HRQoL by concurrently administering 2 HRQoL instruments in populations of children. METHODS: Data were from 2 Australian community-based studies: Language for Learning (children with typical and low language at age 4 years, n = 1012) and the Statewide Comparison of Outcomes study (children with hearing loss, n = 108). HRQoL was measured using the parent-reported Health Utilities Index Mark 3 (HUI3) and the Pediatrics Quality of Life Inventory 4.0 (PedsQL) generic core scale. Agreement between the HRQoL instruments was assessed using intraclass correlation and Bland-Altman plots. RESULTS: Children with low language and with hearing loss had lower HRQoL than children with normal language; the worst HRQoL was experienced by children with both. The lower HRQoL was mainly due to impaired school functioning (PedsQL) and speech and cognition (HUI3). Children with hearing loss also had impaired physical and social functioning (PedsQL), vision, hearing, dexterity, and ambulation (HUI3). Correlations between instruments were poor to moderate, with low agreement. CONCLUSIONS: Children with low language and congenital hearing loss might benefit from interventions targeting overall health and well-being, not just their impairments. The HUI3 and PedsQL each seemed to provide unique information and thus may supplement each other in assessing HRQoL of young children, including those with low language or congenital hearing loss.


Assuntos
Percepção Auditiva , Comportamento Infantil , Linguagem Infantil , Crianças com Deficiência/psicologia , Perda Auditiva/diagnóstico , Audição , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Pessoas com Deficiência Auditiva/psicologia , Qualidade de Vida , Inquéritos e Questionários , Fatores Etários , Austrália , Estudos de Casos e Controles , Pré-Escolar , Pesquisa Comparativa da Efetividade , Efeitos Psicossociais da Doença , Crianças com Deficiência/reabilitação , Educação de Pessoas com Deficiência Auditiva , Feminino , Perda Auditiva/congênito , Perda Auditiva/psicologia , Perda Auditiva/reabilitação , Humanos , Transtornos do Desenvolvimento da Linguagem/psicologia , Transtornos do Desenvolvimento da Linguagem/reabilitação , Inclusão Escolar , Masculino , Pessoas com Deficiência Auditiva/reabilitação , Valor Preditivo dos Testes , Ensaios Clínicos Controlados Aleatórios como Assunto , Reprodutibilidade dos Testes
5.
J Pediatr ; 220: 56-63, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32147220

RESUMO

OBJECTIVE: To externally validate the independent value of objectively diagnosed diffuse white matter abnormality (DWMA; also known as diffuse excessive high signal intensity) volume to predict neurodevelopmental outcomes in very preterm infants (≤31 weeks of gestational age). STUDY DESIGN: A prospective, multicenter, regional population-based cohort study in 98 very preterm infants without severe brain injury on magnetic resonance imaging (MRI). DWMA volume was diagnosed objectively on structural MRI at term-equivalent age using our published algorithm. Multivariable linear regression was used to assess the value of DWMA volume to predict cognitive and language scores on the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) at 2 years corrected age. RESULTS: Of the infants who returned for follow-up (n = 74), the mean (SD) gestational age was 28.2 (2.4) weeks, and 42 (56.8%) were boys. In bivariable analyses, DWMA volume was a significant predictor of Bayley-III cognitive and language scores. In multivariable analyses, controlling for known predictors of Bayley-III scores (ie, socioeconomic status, gestational age, sex, and global brain abnormality score), DWMA volume remained a significant predictor of cognitive (P < .001) and language (P = .04) scores at 2 years. When dichotomized, objectively diagnosed severe DWMA was a significant predictor of cognitive and language impairments, whereas visual qualitative diagnosis of DWMA was a poor predictor. CONCLUSIONS: In this multicenter, prospective cohort study, we externally validated our previous findings that objectively diagnosed DWMA is an independent predictor of cognitive and language development in very preterm infants. We also demonstrated again that visually-diagnosed DWMA is not predictive of neurodevelopmental outcomes.


Assuntos
Transtornos Cognitivos/diagnóstico , Lactente Extremamente Prematuro , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Imagem por Ressonância Magnética , Substância Branca/anormalidades , Substância Branca/diagnóstico por imagem , Algoritmos , Pré-Escolar , Estudos de Coortes , Feminino , Seguimentos , Humanos , Recém-Nascido , Masculino , Análise Multivariada , Sensibilidade e Especificidade
6.
Med. infant ; 27(1): 10-16, Marzo de 2020. tab
Artigo em Espanhol | LILACS, BINACIS, UNISALUD | ID: biblio-1118522

RESUMO

El objetivo de este trabajo fue la evaluación funcional del neurodesarrollo de niños que requirieron terapias complejas neonatales entre los 24 y 30 meses de vida. Se incluyeron 104 pacientes evaluados en el Servicio de Clínicas Interdisciplinarias del Neurodesarrollo del Hospital de Pediatría Juan P. Garrahan, mediante pruebas estandarizadas; cuestionarios auto administrados y datos extraídos del interrogatorio, el examen físico y la historia clínica. A partir de los mismos los pacientes fueron agrupados según el grado de compromiso de su funcionalidad en dos grupos: el primero sin compromiso o compromiso leve y el segundo con compromiso moderado o severo. La evaluación funcional intenta desde una perspectiva biopsicosocial evaluar las habilidades, las dificultades y las características del entorno, que pueden ser tanto facilitadores como barreras para el desarrollo de la persona. De esta manera, permite un abordaje holístico del paciente y muestra como gran fortaleza frente a los diagnósticos categórico y etiológico, la adecuación de los sistemas de apoyos necesarios para cada paciente particular. En concordancia con la bibliografía sobre el riesgo biológico aumentado de esta población, el 44.2% de los niños de la muestra se encontraron dentro del grupo con compromiso funcional moderado/severo. En el análisis univariado las variables que presentaron asociación significativa con el grado de severidad del funcionamiento fueron la prematurez extrema, la displasia broncopulmonar, las lesiones en las ecografías cerebrales neonatales, internaciones neonatales prolongadas y los síndromes genéticos. Entre los factores medio-ambientales, se encontró asociación con progenitor solo y necesidad básicas insatisfechas (AU)


The aim of this study was the functional assessment of the neurodevelopment of children who require complex neonatal interventions between 24 and 30 months of life. Overall, 104 patients were evaluated at the Department of Interdisciplinary Clinics of Neurodevelopment at Hospital de Pediatría Juan P. Garrahan, with standardized tests, self-administered questionnaires and data gleaned from the interview, physical examination, and clinical records. Based on these data, the patients were divided into two groups according to the degree of functional involvement: a first group without or with mild functional compromise and a second group with moderate or severe compromise. From a biopsychosocial perspective, the purpose of functional assessment is the evaluation of skills, difficulties, and environmental characteristics that may be either facilitators or barriers to personal development. Thereby the assessment allows for a holistic approach of the patient and, unlike categorical and etiologic diagnosis, may lead to the adequate selection of the necessary support systems for each individual patient. In agreement with the literature on the increased biological risk in this population, 44.2% of the children in this sample were in the moderate/severe functional compromise group. In univariate analysis, the variables that were statistically significantly associated with degree of severity of function were extreme prematurity, bronchopulmonary dysplasia, lesion on neonatal ultrasonography, prolonged neonatal hospitalization, and genetic syndromes. Among environmental factors a significant association was found with a single parent and unsatisfied basic needs (AU)


Assuntos
Humanos , Pré-Escolar , Transtornos Psicomotores/diagnóstico , Desenvolvimento Infantil , Deficiências do Desenvolvimento , Nascimento Prematuro , Transtornos do Neurodesenvolvimento/diagnóstico , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Displasia Broncopulmonar , Estudos Prospectivos , Estudos de Coortes , Cardiopatias Congênitas/cirurgia , Doenças Genéticas Inatas
7.
Eur J Paediatr Neurol ; 26: 75-81, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32089418

RESUMO

BACKGROUND: Language is a complex neurodevelopmental phenomenon. Approximately 45% of children born very preterm (VP) show mild-to-severe language problems throughout childhood. Nevertheless, in most hospitals in Europe language functions are not routinely assessed at follow-up. OBJECTIVE: To give clear indications for extensive language assessment in school-aged children born VP, based on routinely assessed intelligence and behavioral problems. METHOD: Language functions of 63 10-year-old children born VP (<32 weeks' gestation) without major handicaps were compared to their intellectual and executive functions and behavioral problems. Using multiple linear regression analyses, the predictive value of perinatal factors and the association with neurodevelopmental factors of low language were measured. RESULTS: The mean language score was significantly lower than the verbal intelligent quotient (VIQ; mean difference = 6.4, p < .001, d=.48) and the mean vocabulary knowledge (mean difference = 9.3, p < .001, d=.70). Besides, VIQ (ß = .649, p = .001) and performance IQ (PIQ; ß = .260, p = .035) were significantly associated with language scores. Significant predictors of language scores were number of days of assisted ventilation (ß = -.592, p = .015) and mother's vocabulary knowledge (ß =.473, p = .014), rather than mother's educational level (ß =.139, p = .956). CONCLUSIONS: Children born VP had language problems that were not expected from their significantly higher VIQ and vocabulary knowledge. Clinicians assessing these children should be aware of possible language problems, which cannot be detected with a simple vocabulary task. Our findings provide evidence of the need for adequate language assessments by a speech-language pathologist in children born VP, especially in those with VIQ scores in the low average range.


Assuntos
Lactente Extremamente Prematuro , Transtornos do Desenvolvimento da Linguagem/etiologia , Idioma , Adolescente , Criança , Europa (Continente) , Feminino , Seguimentos , Idade Gestacional , Humanos , Recém-Nascido , Inteligência , Testes de Inteligência , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/epidemiologia , Testes de Linguagem , Masculino , Gravidez
8.
J Autism Dev Disord ; 50(8): 2957-2972, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32056115

RESUMO

This systematic review examined definitions of "nonverbal" or "minimally verbal" and assessment measures used to evaluate communication in intervention studies focusing on improving expressive verbal communication in children with autism spectrum disorder (ASD). We reviewed sample size, number of participants, participant age, and male/female representation. Our analysis yielded relatively few studies with non/minimally verbal children with ASD focusing on verbal expressive communication. Further, we found large inconsistencies in measures used, definitions of "nonverbal" and "minimally verbal", and ages targeted. Guidelines are suggested to create a more uniform assessment protocol with systematic descriptions of early communication learners as a foundational step for understanding the heterogeneity in this group and replicating research findings for this subgroup of children with ASD.


Assuntos
Transtorno do Espectro Autista/diagnóstico , Transtornos do Desenvolvimento da Linguagem/classificação , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Comunicação não Verbal , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Comunicação não Verbal/psicologia
9.
J Nerv Ment Dis ; 208(2): 143-146, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31929463

RESUMO

The aim of this study was to identify major risk factors and sociodemographic characteristics responsible for speech and language delay/disorders. Two hundred twenty-eight children (aged 24-72 months) with speech and language delay/disorders participated in this study. The Ankara Developmental Screening Inventory and The Peabody Picture Vocabulary Test were used to assess language profiles and developmental stages of children. Low income, nonattendance in preschool education, low maternal education, having two or more siblings, later birth order (order of siblings), family history of speech and language delay/disorders, preterm birth, low birth weight, and birth complications or the need for intensive care support during neonatal period were identified as risk factors (all p < 0.005). Both sociodemographic and biologic factors were associated with speech and language delay/disorders. Awareness of these factors may provide a chance for earlier diagnosis and intervention. Identification of risk factors of these children would contribute to our knowledge in this field.


Assuntos
Transtornos do Desenvolvimento da Linguagem/etiologia , Peso ao Nascer , Criança , Pré-Escolar , Escolaridade , Características da Família , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Masculino , Testes Neuropsicológicos , Fatores de Risco , Fatores Socioeconômicos
10.
Dyslexia ; 26(1): 3-17, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31994263

RESUMO

Children of reading age diagnosed with dyslexia show deficits in reading and spelling skills, but early markers of later dyslexia are already present in infancy in auditory processing and phonological domains. Deficits in lexical development are not typically associated with dyslexia. Nevertheless, it is possible that early auditory/phonological deficits would have detrimental effects on the encoding and storage of novel lexical items. Word-learning difficulties have been demonstrated in school-aged dyslexic children using paired associate learning tasks, but earlier manifestations in infants who are at family risk for dyslexia have not been investigated. This study assessed novel word learning in 19-month-old infants at risk for dyslexia (by virtue of having one dyslexic parent) and infants not at risk for any developmental disorder. Infants completed a word-learning task that required them to map two novel words to their corresponding novel referents. Not at-risk infants showed increased looking time to the novel referents at test compared with at-risk infants. These findings demonstrate, for the first time, that at-risk infants show differences in novel word-learning (fast-mapping) tasks compared with not at-risk infants. Our findings have implications for the development and consolidation of early lexical and phonological skills in infants at family risk of later dyslexia.


Assuntos
Dislexia/diagnóstico , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Aprendizagem por Associação de Pares , Feminino , Humanos , Lactente , Masculino , Fonética , Leitura
11.
J Autism Dev Disord ; 50(4): 1295-1309, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31901121

RESUMO

Impairments in structural language and pragmatics are well recognized in different neurodevelopmental disorders, yet in clinical work the discrimination of children with various language difficulties into different diagnostic profile is still a major challenge. Using the CCC-2 questionnaire this study assesses and compares language competences in a sample of Italian children (aged 8-10) with typical development (n = 26) and in children with different neurodevelopmental conditions: high-functioning Autism Spectrum Disorder (n = 19), Language Disorder with associated Developmental Dyslexia (n = 23), Developmental Dyslexia without linguistic impairments (n = 21). The results supported the validity of CCC2 as screening measure that is able to distinguish children with communication impairments from non-impaired peers.


Assuntos
Transtorno do Espectro Autista/psicologia , Dislexia/psicologia , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Neurodesenvolvimento/psicologia , Inquéritos e Questionários/normas , Adolescente , Criança , Feminino , Humanos , Itália , Transtornos do Desenvolvimento da Linguagem/psicologia , Linguística , Masculino , Reprodutibilidade dos Testes , Traduções
12.
J Autism Dev Disord ; 50(4): 1159-1171, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31907729

RESUMO

In order to better understand protective factors for internalizing problems, this longitudinal study examined positive emotions, emotion awareness and (non-)emotional communication skills in relation to somatic complaints and social anxiety in children with (N = 104) and without (N = 183) Developmental Language Disorder (DLD) using self-reported measures twice with a 9-month interval. Additionally, parents reported on their child's communication problems and emotion communication at Time 1. Most importantly, since we found that increasing levels of emotion awareness related to decreases in social anxiety and somatic complaints in children with and without DLD, we conclude that children with DLD are likely to benefit from interventions aimed at improving their emotion awareness in addition to language interventions.


Assuntos
Mecanismos de Defesa , Emoções/fisiologia , Medo/fisiologia , Medo/psicologia , Transtornos do Desenvolvimento da Linguagem/psicologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Estudos Longitudinais , Masculino , Pais/psicologia , Autorrelato
13.
J Autism Dev Disord ; 50(7): 2556-2572, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30877417

RESUMO

We investigated gesture production in infants at high and low risk for autism spectrum disorder (ASD) and caregiver responsiveness between 12 and 24 months of age and assessed the extent to which early gesture predicts later language and ASD outcomes. Participants included 55 high-risk infants, 21 of whom later met criteria for ASD, 34 low-risk infants, and their caregivers. Results indicated that (a) infants with ASD outcomes used fewer gestures and a lower proportion of developmentally advanced gesture-speech combinations; (b) caregivers of all the infants provided similar rates of contingent responses to their infants' gestures; and (c) gesture production at 12 months predicted subsequent receptive language and ASD outcomes within the high-risk group.


Assuntos
Transtorno Autístico/diagnóstico , Transtorno Autístico/psicologia , Cuidadores/psicologia , Desenvolvimento Infantil/fisiologia , Gestos , Desenvolvimento da Linguagem , Pré-Escolar , Feminino , Humanos , Lactente , Idioma , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/psicologia , Masculino , Fatores de Risco , Resultado do Tratamento
15.
J Autism Dev Disord ; 50(5): 1621-1638, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30783899

RESUMO

In the present study, language performance on standardized assessments (e.g., overall verbal performance, receptive and expressive vocabulary) and spontaneous language produced in play was compared between preschool-aged boys with autism spectrum disorder (nASD, n = 25) and boys with fragile X syndrome (FXS, n = 16). At the group-level, we observed weaknesses in the language skills of boys with nASD relative to those with FXS (e.g., when considering raw score performance, standard score performance relative to nonverbal cognitive skills, frequency of talk in play), after controlling for nonverbal IQ and ASD symptom severity. Moreover, although individually most children in both groups demonstrated language delays relative to CA-expectations, language delays relative to nonverbal level-expectations were more common in boys with nASD.


Assuntos
Transtorno do Espectro Autista/psicologia , Síndrome do Cromossomo X Frágil/psicologia , Transtornos do Desenvolvimento da Linguagem/psicologia , Testes de Linguagem , Idioma , Transtorno do Espectro Autista/diagnóstico , Pré-Escolar , Feminino , Síndrome do Cromossomo X Frágil/diagnóstico , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Masculino , Vocabulário
16.
J Autism Dev Disord ; 50(5): 1668-1682, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30790193

RESUMO

This study examined implementation of an evidence-based home reading program by caregivers of children with language impairment. Caregivers received materials and supports to read with their children for 15 weeks, four times weekly; in total, 128 caregivers were enrolled. Survival analysis showed that 55% of caregivers completed the program, and the majority of dropouts did so early in the intervention. Mulitnominal logistic regression results showed that dropout was associated with household income, child literacy skills, and receipt of behavior-change techniques by caregivers, especially financial incentives (50 cents per book reading). Results may advance the science of implementation in the area of early childhood disability and could provide suggestions to improve caregivers' effectiveness in implementing interventions to their children.


Assuntos
Cuidadores/psicologia , Intervenção Educacional Precoce/métodos , Transtornos do Desenvolvimento da Linguagem/psicologia , Transtornos do Desenvolvimento da Linguagem/terapia , Alfabetização/psicologia , Leitura , Criança , Pré-Escolar , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Masculino , Análise de Sobrevida
17.
Lang Speech Hear Serv Sch ; 51(1): 128-143, 2020 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-31684815

RESUMO

Purpose The purpose of this study was to provide reference data and evaluate the psychometric properties for the finite verb morphology composite (FVMC) measure in children between 4 and 9 years of age from the database of the Edmonton Narrative Norms Instrument (ENNI; Schneider, Dubé, & Hayward, 2005). Method Participants included 377 children between age 4 and age 9, including 300 children with typical language and 77 children with language impairment (LI). Narrative samples were collected using a story generation task. FVMC scores were computed from the samples. Split-half reliability, concurrent criterion validity, and diagnostic accuracy for FVMC were further evaluated. Results Children's performance on FVMC increased significantly between age 4 and age 9 in the typical language and LI groups. Moreover, the correlation coefficients for the split-half reliability and concurrent criterion validity of FVMC were medium to large (rs ≥ .429, ps < .001) at each age level. The diagnostic accuracy of FVMC was good or acceptable from age 4 to age 7, but it dropped to a poor level at age 8 and age 9. Conclusion With the empirical evidence, FVMC is appropriate for identifying children with LI between age 4 and age 7. The reference data of FVMC could also be used for monitoring treatment progress. Supplemental Material https://doi.org/10.23641/asha.10073183.


Assuntos
Transtornos do Desenvolvimento da Linguagem/diagnóstico , Testes de Linguagem/normas , Psicometria/métodos , Patologia da Fala e Linguagem/normas , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Masculino , Narração , Valores de Referência , Reprodutibilidade dos Testes
18.
S Afr J Commun Disord ; 66(1): e1-e8, 2019 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-31793312

RESUMO

BACKGROUND: This conceptual article is inspired by the first phase of a doctoral research project that aimed to develop and validate a bilingual language assessment test for IsiZulu-English-speaking children in grades 1, 2 and 3 with language-based learning disabilities (L-b LDs) in South Africa. OBJECTIVES: Phase 1, systematic literature review, pretesting and formulating of a theoretical framework, with the aim to determine early indicators of L-b LDs; this is important for developing a clinical language test as it determines its constructs. METHOD: Thematic analysis was used to develop the models. RESULTS: This article reviews the literature on indicators and definitions of L-b LD, introduces models that were developed in the study to conceptualise L-b LD and discusses implications for language test development. CONCLUSION: The models provided in this article conceptualise L-b LD and identify its early indicators. The application of these models in both educational and clinical settings is proposed for differentiation of L-b LD.


Assuntos
Transtornos do Desenvolvimento da Linguagem , Deficiências da Aprendizagem , Modelos Teóricos , Multilinguismo , Criança , Linguagem Infantil , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Testes de Linguagem , Deficiências da Aprendizagem/diagnóstico , África do Sul
19.
J Neurodev Disord ; 11(1): 37, 2019 12 16.
Artigo em Inglês | MEDLINE | ID: mdl-31838999

RESUMO

BACKGROUND: During the first 3-years of life, as the brain undergoes dramatic growth, children begin to develop speech and language. Hallmarks of this progression are seen when children reach developmental milestones, forming the foundation of language. Expressive language milestones, such as the production of a child's first word, are delayed in 5-8% of children. While for some children delays in reaching these milestones are harbingers of developmental disorders, for others expressive language delays appear to resolve. Regardless of whether or not early language skills appear resolved, difficulty with later comprehension is a likely outcome. Whether this heightened risk for poor comprehension differs based on text features, individual characteristics, or receipt of intervention remains unknown. Moreover, this relationship between expressive language development and comprehension is not yet linked to neurobiology, though the inferior longitudinal fasciculus (ILF) is a potential neurobiological correlate. Therefore, we investigated the impact of, and interactions between, expressive language development, early intervention, and the ILF on comprehension. METHODS: Longitudinal recurrent survival analyses predicted the risk of answering a comprehension question incorrectly. Predictors of comprehension included expressive language development, passage features, participant characteristics, fractional anisotropy, receipt of early intervention, and later diagnosis of speech or language disorders. RESULTS: Children with later expressive language milestones had poorer comprehension. When comprehension text features were examined, children with later milestones had poorer listening and reading comprehension, and poorer narrative and expository comprehension. The left ILF acted as a neurodevelopmental correlate, one that moderated the relationship between expressive language milestones and comprehension. Specifically, the left ILF exacerbated the relationship for those who did not receive early intervention and buffered the relationship for those who received intervention services. Early intervention decreased the risk of poor comprehension by 39% for children later diagnosed with a speech or language disorder. CONCLUSIONS: Early intervention should be provided for children with delayed expressive language milestones, particularly those who are at risk for speech or language disorders. The ILF plays a critical role in the relationship between expressive language development and comprehension, which may be that of a protective factor for children with the most severe early issues with speech and language.


Assuntos
Compreensão/fisiologia , Transtornos do Desenvolvimento da Linguagem/patologia , Desenvolvimento da Linguagem , Córtex Pré-Frontal/patologia , Leitura , Percepção da Fala/fisiologia , Lobo Temporal/patologia , Criança , Imagem de Difusão por Ressonância Magnética , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Masculino , Vias Neurais , Córtex Pré-Frontal/fisiopatologia , Lobo Temporal/fisiopatologia
20.
Codas ; 31(5): e20180121, 2019.
Artigo em Português, Inglês | MEDLINE | ID: mdl-31691745

RESUMO

Apraxia of speech is defined as the inability to sequence the movements required for accurate articulatory production, traditionally involving a deficit in speech motor programming. Language clinicians often confront about speech inconsistency clinical cases, which raise questions concerning the differential diagnosis between apraxia and language disorders. Such problem often results in the difficulty to establish an adequate treatment decision. In this work, we discuss a clinical report in which both diagnosis and treatment raise questions about the apraxic speech condition in childhood. We start from the recognition that, in apraxia, it seems imperative to consider that the body to be considered is the one that surpasses its organic functions and structure. Clinical consequences are drawn from the premise that the human body is one whose ear can listen, and mouth can speak, i.e., the organic structure is a material realm open to the incidence of language and its "music", which creates the speaking body.


Assuntos
Apraxias/diagnóstico , Apraxias/terapia , Transtornos do Desenvolvimento da Linguagem/diagnóstico , Transtornos do Desenvolvimento da Linguagem/terapia , Terapia da Linguagem/métodos , Distúrbios da Fala/diagnóstico , Distúrbios da Fala/terapia , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Medida da Produção da Fala
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