Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 4.699
Filtrar
1.
Int J Mol Sci ; 22(6)2021 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-33803557

RESUMO

Marchigian Sardinian alcohol-preferring (msP) rats serve as a unique model of heightened alcohol preference and anxiety disorders. Their innate enhanced stress and poor stress-coping strategies are driven by a genetic polymorphism of the corticotropin-releasing factor receptor 1 (CRF1) in brain areas involved in glucocorticoid signaling. The activation of glucocorticoid receptors (GRs) regulates the stress response, making GRs a candidate target to treat stress and anxiety. Here, we examined whether mifepristone, a GR antagonist known to reduce alcohol drinking in dependent rats, decreases innate symptoms of anxiety in msPs. Male and female msPs were compared to non-selected Wistar counterparts across three separate behavioral tests. We assessed anxiety-like behavior via the novelty-induced hypophagia (NIH) assay. Since sleep disturbances and hyperarousal are common features of stress-related disorders, we measured sleeping patterns using the comprehensive lab monitoring system (CLAMS) and stress sensitivity using acoustic startle measures. Rats received an acute administration of vehicle or mifepristone (60 mg/kg) 90 min prior to testing on NIH, acoustic startle response, and CLAMS. Our results revealed that both male and female msPs display greater anxiety-like behaviors as well as enhanced acoustic startle responses compared to Wistar counterparts. Male msPs also displayed reduced sleeping bout duration versus Wistars, and female msPs displayed greater acoustic startle responses versus male msPs. Importantly, the enhanced anxiety-like behavior and startle responses were not reduced by mifepristone. Together, these findings suggest that increased expression of stress-related behaviors in msPs are not solely mediated by acute activation of GRs.


Assuntos
Ansiedade/patologia , Comportamento Animal , Mifepristona/farmacologia , Receptores de Glucocorticoides/antagonistas & inibidores , Animais , Ansiedade/complicações , Ansiedade/fisiopatologia , Nível de Alerta/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Feminino , Masculino , Ratos Wistar , Receptores de Glucocorticoides/metabolismo , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/fisiopatologia
2.
Nat Commun ; 12(1): 2289, 2021 04 20.
Artigo em Inglês | MEDLINE | ID: mdl-33879784

RESUMO

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01-1.48), 1.37 (1.10-1.72), and 1.24 (0.98-1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.


Assuntos
Demência/epidemiologia , Demência/etiologia , Transtornos do Sono-Vigília/complicações , Sono/fisiologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Demência/fisiopatologia , Feminino , Seguimentos , Humanos , Incidência , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Fatores de Risco , Privação do Sono/complicações , Privação do Sono/fisiopatologia , Transtornos do Sono-Vigília/fisiopatologia , Fatores de Tempo , Reino Unido/epidemiologia
3.
Ann Agric Environ Med ; 28(1): 193-197, 2021 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-33775088

RESUMO

INTRODUCTION: Overweight and obesity affect an increasing number of children and adolescents in Poland. This excessive body weight usually coexists with sleep disorders and other afflictions, which is worrisome. OBJECTIVE: The aim of the study was to assess the prevalence of overweight, obesity, and sleep disorders among adolescents and demonstrate their relationships. MATERIAL AND METHODS: The study included 1,002 students. Nutritional habits and subjective assessment of sleep were evaluated with the author's survey; daytime sleepiness and sleep quality were assessed with Epworth Sleepiness Scale (ESS) and Sleep Quality Scale (SQS). Statistical calculations were performed with the STATISTICA 12.0 programme. RESULTS: 24.7% of adolescents suffered from overweight or obesity, 38% reported sleep problems in subjective assessment, 10.5% exhibited excessive daytime sleepiness, determined by ESS, and 14.3% had impaired quality of sleep as determined by SQS. Gender affected all the discussed problems. Type of school affected all the above, except for daytime sleepiness. In the group with overweight and obesity, 46.6% of individuals reported sleep problems in subjective assessment. About 59.1% of adolescents reported chronic fatigue. Reduced concentration and difficulties in learning were reported in 36.3% of all students, and in 46% of students with overweight and obesity. CONCLUSIONS: The problem of excess body weight is a very alarming phenomenon since it affects almost 1/4 of the students. Almost half of the students with overweight and obesity reported sleep problems, which is strongly correlated with the type of school. Furthermore, excess body weight influenced the prevalence of reduced concentration and learning difficulties among adolescents.


Assuntos
Obesidade/epidemiologia , Sobrepeso/epidemiologia , Transtornos do Sono-Vigília/epidemiologia , Adolescente , Saúde do Adolescente , Feminino , Humanos , Masculino , Obesidade/fisiopatologia , Sobrepeso/fisiopatologia , Polônia , Prevalência , Sono , Transtornos do Sono-Vigília/fisiopatologia
4.
Int J Mol Sci ; 22(3)2021 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-33572767

RESUMO

Sleep problems are frequently associated with the principal diagnostic criteria for many mental disorders. Alterations in the sleep of depressive patients are of high clinical significance because continuous sleep problems raise the chance of relapse, recurrence, or suicide, as well as the need for augmenting medications. Most antidepressants have been proven to influence the sleep architecture. While some classes of antidepressants improve sleep, others may cause sleep impairment. The successful treatment of depressive disorder also requires an understanding of the effects of antidepressants on sleep. This article briefly reviews the physiology of sleep and the typical alterations in the sleep architecture in depressive patients and updates the different effects of the majority of antidepressants including novel drugs in clinical practice on sleep. The summary of the updated scientific findings of the relationship between depression and sleep disturbances could be clinically beneficial in choosing the best medication for depressive patients with concurrent sleep disorders.


Assuntos
Antidepressivos/uso terapêutico , Transtorno Depressivo/complicações , Transtorno Depressivo/tratamento farmacológico , Transtornos do Sono-Vigília/complicações , Transtornos do Sono-Vigília/tratamento farmacológico , Sono/efeitos dos fármacos , Animais , Antidepressivos/farmacologia , Transtorno Depressivo/fisiopatologia , Humanos , Transtornos do Sono-Vigília/fisiopatologia
6.
Biomed Pharmacother ; 134: 111150, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33395599

RESUMO

Risk factors related to the development of acetaminophen (APAP)-induced adverse reactions and liver injury remain uncertain. Sleep disorders have been linked to some health outcomes. This study examined the associations of sleep disorders with APAP-induced adverse reactions or liver injury and the possible mechanisms. From NIS database, adverse reactions, liver injury and sleep disorders were identified. Factors associated with the risk of the total adverse effects or liver injury were examined with logistic regression. From Gene Expression Omnibus database, datasets GSE111828, containing transcriptome data based on RNA-seq analysis from liver samples extracted from mice post APAP administration, and GSE92913, containing transcriptome data based on microarray analysis from liver samples extracted from mice with sleep deprivation, were analyzed. A total of 4372754 patients without and 91314 patients with sleep disorders were eligible for analyses. Both before and after propensity score matching, APAP-induced adverse reactions were higher in patients with sleep disorders than in patients without. In multivariate regression, sleep disorders were associated with higher odds of APAP-induced adverse reactions (adjusted OR [aOR] 2.005, 95 % CI 1.343-2.995) and liver injury (aOR 2.788, 95 % CI 1.310-5.932). Genes that were enriched in bile secretion and retinol metabolism and PPAR signaling pathways were basically down-regulated in livers of mice after APAP administration and livers of mice with sleep deprivation. This study shows that sleep disorders may be novel independent risk factors for APAP-associated adverse reactions and liver injury and provides bioinformation linking sleep disorders to increased risk of APAP-induced liver injury.


Assuntos
Acetaminofen/efeitos adversos , Analgésicos não Entorpecentes/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Transtornos do Sono-Vigília/complicações , Adulto , Animais , Doença Hepática Induzida por Substâncias e Drogas/diagnóstico , Doença Hepática Induzida por Substâncias e Drogas/genética , Estudos Transversais , Bases de Dados Genéticas , Modelos Animais de Doenças , Feminino , Regulação da Expressão Gênica , Humanos , Pacientes Internados , Masculino , Camundongos , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco , Transdução de Sinais , Sono , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/fisiopatologia , Transcriptoma
7.
Rev. neurol. (Ed. impr.) ; 72(1): 9-15, 1 ene., 2021. tab
Artigo em Espanhol | IBECS | ID: ibc-200035

RESUMO

INTRODUCCIÓN: Recientemente, se ha incrementado la atención hacia causas metabólicas de la pérdida de células dopaminérgicas en la enfermedad de Parkinson (EP), dada la intolerancia a la glucosa que pueden presentar estos pacientes. Un síndrome caracterizado por resistencia a la insulina es el síndrome metabólico. OBJETIVO: Determinar la prevalencia y las características clínicas del síndrome metabólico y sus componentes en pacientes con EP. PACIENTES Y MÉTODOS: Se analizaron variables de 99 pacientes con EP. Se registraron escalas que evalúan las funciones motora, no motora y cognitiva, los trastornos del sueño y la calidad de vida. El síndrome metabólico se diagnosticó según los criterios de la Organización Mundial de la Salud. RESULTADOS: La prevalencia de síndrome metabólico se notificó en un 8%. Al subdividir a los pacientes en función de los criterios positivos de síndrome metabólico, no se observaron diferencias significativas en las funciones motora y cognitiva, la calidad de vida ni los trastornos del sueño entre los grupos. No obstante, pacientes con síndrome metabólico mostraron peores puntuaciones en la escala de síntomas no motores en comparación con pacientes sin el síndrome, especialmente en cuanto a tracto gastrointestinal, estado de ánimo/apatía, función sexual, problemas perceptivos y misceláneos. No se observaron diferencias significativas en las características clínicas al agrupar a los pacientes sobre la base del componente único de síndrome metabólico presente. CONCLUSIÓN: El síndrome metabólico podría tener un efecto sobre la sintomatología no motora en la EP, ya que los pacientes con este síndrome mostraron peores puntuaciones en la escala de síntomas no motores


INTRODUCTION: Focus on the metabolic causes underlying dopaminergic cell loss in Parkinson's disease (PD) has increased lately. Glucose imbalances have been shown to be present in patients with PD. A syndrome characterized principally by insulin resistance and glucose dysregulations is metabolic syndrome. Scarce literature has evaluated the relation between these two diseases. AIM: To determine the prevalence and clinical features of metabolic syndrome and its components in patients with PD. PATIENTS AND METHODS: We analyzed data from 99 patients with PD diagnosis. Scales that evaluate motor, non-motor, and cognitive function, as well as sleep disorders and quality of life were registered. Metabolic syndrome was diagnosed according to the World Health Organization criteria. RESULTS: Metabolic syndrome was reported in 8% of the population. When subdividing patients based on positivity to metabolic syndrome criteria, no significant differences in motor and cognitive function, as well as quality of life and sleep disorders were observed between groups. However, patients with metabolic syndrome showed worse scores in Non-Motor Symptom Scale compared to patients without the syndrome, especially gastrointestinal, mood/apathy, sexual function, perceptual and miscellaneous symptoms. No significant differences in clinical correlates were observed when grouping patients based on which single metabolic syndrome component was present. CONCLUSION. Metabolic syndrome might have an effect on non-motor symptomatology in PD, as patients with metabolic syndrome showed worse scores in Non-Motor Symptom Scale


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/fisiopatologia , Doença de Parkinson/epidemiologia , Doença de Parkinson/fisiopatologia , Estudos Prospectivos , Qualidade de Vida , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/fisiopatologia , Prevalência , Distribuição por Sexo , Escolaridade , Fatores de Risco , Estatísticas não Paramétricas , Análise de Variância , México/epidemiologia
8.
Res Nurs Health ; 44(2): 268-278, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33368378

RESUMO

Traumatic injuries affect millions of Americans annually, resulting in $671 billion in healthcare costs and lost productivity. Postinjury symptoms, like pain, sleep disturbance, anxiety, depression, and stressor-related disorders are highly prevalent following traumatic orthopedic injuries (TOI) and may contribute to negative long-term outcomes. Symptoms rarely present in isolation, but in clusters of two or more symptoms that co-occur to affect health in aggregate. Identifying symptom cluster profiles following TOI may identify those at highest risk for negative outcomes. Dysregulation of brain-derived neurotrophic factor (BDNF) is a potential biological mechanism responsible for symptom cluster profile membership after TOI and may be targeted in future precision-health applications. The purpose of this paper is to present the protocol of a cross-sectional study designed to identify symptom cluster profiles and measure the extent to which the BDNF val66met mutation and serum concentration of BDNF are associated with membership in symptom cluster profiles. We plan to recruit 150 TOI survivors within the first 72 h of injury. The study aims are to (1) describe TOI survivors' membership in symptom cluster profiles, indicated by pain, sleep disturbance, and symptoms of anxiety, depression, and stressor-related disorders, immediately following a TOI; (2) examine associations between demographic and clinical factors and symptom cluster profile membership among TOI survivors; (3) test the hypothesis that low serum concentrations of BDNF are associated with membership among symptom cluster profiles following TOI; and (4) test the hypothesis that the presence of the val66met mutation on one or both alleles of the BDNF gene is associated with membership among symptom cluster profiles following TOI.


Assuntos
Fator Neurotrófico Derivado do Encéfalo/sangue , Fraturas Ósseas/complicações , Transtornos do Sono-Vigília/fisiopatologia , Estudos Transversais , Humanos , Projetos de Pesquisa , Transtornos do Sono-Vigília/sangue , Transtornos do Sono-Vigília/enfermagem , Síndrome
9.
Neurology ; 96(10): e1462-e1469, 2021 03 09.
Artigo em Inglês | MEDLINE | ID: mdl-33361258

RESUMO

OBJECTIVE: To test the hypothesis that reduced slow-wave sleep, or N3 sleep, which is thought to underlie the restorative functions of sleep, is associated with MRI markers of brain aging, we evaluated this relationship in the community-based Framingham Heart Study Offspring cohort using polysomnography and brain MRI. METHODS: We studied 492 participants (age 58.8 ± 8.8 years, 49.4% male) free of neurological diseases who completed a brain MRI scan and in-home overnight polysomnography to assess slow-wave sleep (absolute duration and percentage of total sleep). Volumes of total brain, total cortical, frontal cortical, subcortical gray matter, hippocampus, and white matter hyperintensities were investigated as a percentage of intracranial volume, and the presence of covert brain infarcts was evaluated. Linear and logistic regression models were adjusted for age, age squared, sex, time interval between polysomnography and MRI (3.3 ± 1.0 years), APOE ε4 carrier status, stroke risk factors, sleeping pill use, body mass index, and depression. RESULTS: Less slow-wave sleep was associated with lower cortical brain volume (absolute duration, ß [standard error] = 0.20 [0.08], p = 0.015; percentage, 0.16 [0.08], p = 0.044), lower subcortical brain volume (percentage, 0.03 [0.02], p = 0.034), and higher white matter hyperintensities volume (absolute duration, -0.12 [0.05], p = 0.010; percentage, -0.10 [0.04], p = 0.033). Slow-wave sleep duration was not associated with hippocampal volume or the presence of covert brain infarcts. CONCLUSION: Loss of slow-wave sleep might facilitate accelerated brain aging, as evidence by its association with MRI markers suggestive of brain atrophy and injury. Alternatively, subtle injuries and accelerated aging might reduce the ability of the brain to produce slow-wave sleep.


Assuntos
Encéfalo/diagnóstico por imagem , Encéfalo/crescimento & desenvolvimento , Imagem por Ressonância Magnética/métodos , Transtornos do Sono-Vigília/diagnóstico por imagem , Sono de Ondas Lentas , Idoso , Atrofia , Encéfalo/fisiopatologia , Infarto Encefálico/patologia , Mapeamento Encefálico , Estudos de Coortes , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Polissonografia , Transtornos do Sono-Vigília/fisiopatologia
10.
J. negat. no posit. results ; 5(12): 1558-1574, dic. 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-200239

RESUMO

INTRODUCCIÓN: El embarazo es un proceso fisiológico que produce alteraciones en los patrones del sueño. A nivel fisiológico la falta de sueño se relaciona con problemas de salud tales como hipertensión, enfermedad coronaria, diabetes y depresión. En el embarazo, las alteraciones del sueño son más frecuentes siendo su prevalencia mayor durante el tercer trimestre. La deprivación del mismo durante el embarazo empeora significantemente las condiciones preexistentes de la mujer disminuyendo la actividad física diaria, la productividad y aumentando los síntomas relacionados con el estrés. Las alteraciones del sueño en el embarazo se pueden relacionar con comorbilidad en el recién nacido y resultados adversos materno-fetales. OBJETIVOS: Determinar qué alteraciones del sueño ocurren durante el embarazo, cuáles son sus causas y qué posibles consecuencias podría tener el déficit de sueño durante la gestación a nivel materno-fetal y neonatal. METODOLOGÍA: Se llevó a cabo una revisión sistemática siguiendo los principios de la declaración PRISMA. Se recogieron tanto estudios observacionales como de intervención así como revisiones sistemáticas y meta-análisis y se llevó a cabo un análisis crítico de los resultados. RESULTADOS Y DISCUSIÓN: Se incluyeron finalmente un total de 19 artículos que trataban sobre los efectos de las alteraciones del sueño en los resultados materno-fetales y neonatales y sus causas. Las principales causas de las alteraciones del sueño son los cambios hormonales y fisiológicos propios del embarazo como es el aumento de peso que se hacen más prevalentes conforme progresa la gestación. Las consecuencias maternas engloban principalmente trastornos respiratorios, alteraciones cardiovasculares e inflamatorias y resultados adversos del embarazo como es la cesárea. Los resultados adversos en el recién nacido más estudiados son partos prematuros y recién nacidos con bajo peso para la edad gestacional. CONCLUSIÓN: Con este trabajo se observa que existe una relación entre los trastornos del sueño durante el embarazo y los problemas materno-fetales. Sin embargo, los estudios llevados a cabo hasta la fecha son heterogéneos, emplean herramientas subjetivas y sus conclusiones resultan en ocasiones contradictorias


INTRODUCTION: Pregnancy is a physiologic stage of the women that modifies sleep patterns. Sleep deprivation is associated with pathologies namely hypertensive disorders, coronary artery disease, diabetes and depression. Amongst pregnant women sleep disorders are more frequent being its prevalence higher during the third trimester of gestation. Furthermore, sleep deprivation worsens previous conditions such as low degree of physical activity, productivity and increases stress-related symptoms. Sleep disorders could be associated with comorbidities in the newborn as well as pregnancy/perinatal adverse outcomes. OBJECTIVES: To determine which sleep disorders are associated with pregnancy, their causes and the potential effects that sleep deprivation could exert on pregnancy outcomes and the newborn. METHODOLOGY: We conducted a systematic review following the PRISMA statement. Observational, interventional and systematic reviews/meta-analyses were included and a critical analysis of the results was performed. RESULTS AND DISCUSSION: 19 papers about sleep disorders and pregnancy/perinatal outcomes were finally included. Mains causes of sleep disorders during pregnancy consisted of hormonal changes and weight gain which are more prevalent as gestation progresses. Maternal outcomes associated to sleep disorders comprised respiratory, cardiovascular and inflammatory disorders along with pregnancy adverse outcomes namely caesarean section. Main perinatal adverse outcomes were preterm delivery and small for gestational age. CONCLUSION: We observed an association between sleep disorders during gestation, pregnancy and perinatal adverse outcomes. However, studies conducted to date are heterogeneous and they tend to use subjective tools to assess sleep patterns being results occasionally inconclusive or contradictory


Assuntos
Humanos , Feminino , Gravidez , Recém-Nascido , Complicações na Gravidez/fisiopatologia , Transtornos do Sono-Vigília/fisiopatologia , Resultado da Gravidez
11.
Rev. neurol. (Ed. impr.) ; 71(12): 438-446, 16 dic., 2020. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-199337

RESUMO

INTRODUCCIÓN: El trastorno por déficit de atención/hiperactividad (TDAH) es uno de los trastornos mentales más comunes en la infancia. Los síntomas nucleares del TDAH se tratan con estimulantes como el metilfenidato; aun así, existe mucha controversia respecto a sus efectos secundarios. OBJETIVOS: Analizar los patrones de actividad en niños con TDAH durante un período de 24 horas durante siete días, antes y después de tomar tratamiento farmacológico estimulante (metilfenidato), y observar si existen diferencias entre las diferentes presentaciones del trastorno (subtipo inatento y combinado). PACIENTES Y MÉTODOS: Un total de 30 niños y adolescentes (recién diagnosticados de TDAH según los criterios diagnósticos del DSM-IV) fueron evaluados a través de un actígrafo, un instrumento que permite monitorizar los movimientos corporales analizando los patrones de movimiento y las diferencias entre sueño y vigilia. RESULTADOS: Existen diferencias significativas antes y después de realizar el tratamiento, con niveles de actividad más altos en los pacientes con TDAH antes de empezar el tratamiento y un decrecimiento de esta actividad tras el tratamiento farmacológico. También existen diferencias entre los subtipos inatento y combinado, y el último grupo muestra un nivel de actividad mayor. CONCLUSIONES: El nivel de activación que presentan los sujetos con TDAH es mayor antes de tomar tratamiento, e influye en los patrones circadianos, el sueño y la calidad de vida. El tratamiento farmacológico ayuda a disminuir el nivel de activación


INTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders in childhood. The nuclear symptoms of ADHD are treated with stimulant medication such as methylphenidate; however, there's a lot of controversy regarding its side effects. AIMS. To analyse the activity patterns in children with ADHD during a period of 24 hours for seven days, before and after taking pharmacological treatment with stimulants (methylphenidate) and observe the differences between the different presentations of ADHD (inattentive and combined subtype). PATIENTS AND METHODS: A total of 30 children and adolescents (newly diagnosed with ADHD according to DSM-IV). Analyses were carried out through actigraphy, an instrument that allows us to monitor body movements by analysing movement patterns and differences between sleep and wakefulness. RESULTS: There were significant differences before and after treatment showing higher activity levels in patients with ADHD before treatment, and a decrease in this situation after taking pharmacological treatment. There are also differences between inattentive and combined subtype, showing the last group, higher activity levels. CONCLUSIONS: The level of activation presented by ADHD subjects is higher before taking stimulant treatment, influencing circadian patterns, sleep and quality of life. Pharmacological treatments help to decrease the level of activation


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Ritmo Circadiano/efeitos dos fármacos , Resultado do Tratamento , Polissonografia/métodos , Sono/fisiologia , Transtornos do Sono-Vigília/fisiopatologia , Vigília/fisiologia , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Fatores de Tempo , Actigrafia/métodos
12.
Rev. neurol. (Ed. impr.) ; 71(10): 377-386, 16 nov., 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-198073

RESUMO

Los trastornos del movimiento y de la conducta durante el sueño pueden tener un impacto en la calidad del sueño del paciente y dar lugar a síntomas diurnos. En estos grupos de enfermedades se incluyen entidades como el síndrome de piernas inquietas, los movimientos periódicos de las piernas y las parasomnias del sueño de movimientos oculares rápidos (REM) y no REM. El conocimiento de sus características clínicas y nociones sobre su manejo es de gran importancia para el neurólogo y especialista en sueño por su frecuencia e impacto en la calidad del sujeto. Con frecuencia, estos pacientes son referidos a dichos especialistas, y es relevante conocer que ciertos trastornos del sueño pueden asociarse a otras enfermedades neurológicas


Sleep-related movement and behaviour disorders may have an impact on sleep quality and lead to daytime symptoms. These groups of conditions include diseases such as restless legs syndrome, periodic leg movements, and REM and NREM parasomnias. The knowledge of their clinical features and management is of utmost importance for the neurologist and sleep specialist. Frequently, these patients are referred to such specialists and it is relevant to know that certain sleep disorders may be associated with other neurological conditions


Assuntos
Humanos , Adulto , Transtornos dos Movimentos/fisiopatologia , Transtornos do Sono-Vigília/fisiopatologia , Síndrome das Pernas Inquietas/fisiopatologia , Parassonias do Sono REM/fisiopatologia , Sonhos/fisiologia , Epilepsia/fisiopatologia
13.
Science ; 370(6512): 50-56, 2020 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-33004510

RESUMO

Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep architecture is a frequent antecedent to the onset of dementia in neurodegenerative diseases. The glymphatic system, which clears the brain of protein waste products, is mostly active during sleep. Yet the glymphatic system degrades with age, suggesting a causal relationship between sleep disturbance and symptomatic progression in the neurodegenerative dementias. The ties that bind sleep, aging, glymphatic clearance, and protein aggregation have shed new light on the pathogenesis of a broad range of neurodegenerative diseases, for which glymphatic failure may constitute a therapeutically targetable final common pathway.


Assuntos
Doença de Alzheimer/etiologia , Sistema Glinfático/fisiopatologia , Transtornos do Sono-Vigília/complicações , Sono , Envelhecimento , Doença de Alzheimer/fisiopatologia , Animais , Aquaporina 4/genética , Doenças Cardiovasculares/etiologia , Humanos , Sistema Linfático/fisiopatologia , Camundongos , Polimorfismo Genético , Proteínas Priônicas/metabolismo , Agregados Proteicos , Transtornos do Sono-Vigília/fisiopatologia
14.
Sarcoidosis Vasc Diffuse Lung Dis ; 37(2): 169-178, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33093780

RESUMO

Rationale: An increased incidence of Obstructive Sleep Apnea (OSA) in sarcoidosis has been described in small sample size studies. Fatigue is common in sarcoidosis and OSA could be a relevant, treatable comorbidity. To date, the effect of Continuous Positive Airway Pressure (CPAP) on fatigue has never been assessed. Objectives: To investigate the prevalence of OSA in sarcoidosis, fatigue status and daytime sleepiness in patients of our center. To explore the effect of CPAP in fatigue and daytime sleepiness after 3 months using validated questionnaires. Method: Single group, one center, open-label prospective cohort study. Measurements and main result: We enrolled 68 patients and OSA was diagnosed in 60 (88.2%): 25 (36.8%) were mild while 35 (51.5%) were moderate-to-severe. 38 (55.9%) patients received CPAP but only 20 (30.9%) were compliant at 3-month evaluation. Questionnaires demonstrated fatigue in 34 (50%) and daytime sleepiness in 21 (30.9%). In multivariate regression analysis, Scadding stage and FAS behave as predictors of Apnea-Hypopnea Index (AHI) severity while sleepiness and steroids weren't associated. FAS score (ΔFAS = 6.3; p = 0.001) and ESS score (ΔESS = 2.8; p = 0.005) improved after three months of CPAP. Conclusions: OSA is highly prevalent in patients affected by sarcoidosis. ESS questionnaire is not reliable for OSA screening and other pre-test probability tool should be evaluated in further studies. CPAP leads to a significative reduction of fatigue and daytime sleepiness at three-month. Further studies are needed to confirm the high prevalence of OSA in sarcoidosis and the positive role of CPAP in fatigue. (Sarcoidosis Vasc Diffuse Lung Dis 2020; 37 (2): 169-178).


Assuntos
Pressão Positiva Contínua nas Vias Aéreas , Fadiga/prevenção & controle , Pulmão/fisiopatologia , Respiração , Sarcoidose/epidemiologia , Apneia Obstrutiva do Sono/terapia , Transtornos do Sono-Vigília/prevenção & controle , Sono , Idoso , Pressão Positiva Contínua nas Vias Aéreas/efeitos adversos , Fadiga/diagnóstico , Fadiga/epidemiologia , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Recuperação de Função Fisiológica , Fatores de Risco , Roma/epidemiologia , Sarcoidose/diagnóstico , Sarcoidose/fisiopatologia , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/epidemiologia , Apneia Obstrutiva do Sono/fisiopatologia , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/fisiopatologia , Fatores de Tempo , Resultado do Tratamento
15.
J Pharmacol Sci ; 144(3): 129-138, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32921394

RESUMO

The traditional Japanese (Kampo) medicines yokukansan (YKS) and yokukansankachimpihange (YKSCH) have similar formulas and the same indications. In animals or cultured cells, the neuropharmacological actions of YKS are sometimes more beneficial than those of YKSCH. Since both drugs are used to treat sleep disorders in Japan, we examined the ameliorative effects of YKS and YKSCH on circadian rhythm disturbance and compared their efficacy using a mouse model of circadian rhythm disruption. Ramelteon was used as the positive control. Ramelteon treatment significantly reversed decreased running wheel activity during the advanced dark phase, indicating facilitation of circadian adaptation. YKS treatment also reversed the activity in the early period of drug treatment; however, it was not statistically significant. YKSCH treatment significantly reversed the decreased activity during the advanced dark phase. Plasma melatonin (MT) levels were significantly increased in the YKSCH but not in the YKS group. The ameliorative effect of YKSCH on rhythm disruption was significantly inhibited by coadministration of the MT2 receptor antagonist. Therefore, the therapeutic effect of YKSCH on circadian rhythm disruption would be attributable, to elevated endogenous MT levels. Taken together, YKS and YKSCH have different pharmacological properties and may be more precisely prescribed depending on patients' psychological symptoms.


Assuntos
Adaptação Biológica/efeitos dos fármacos , Ritmo Circadiano/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Kampo , Melatonina/metabolismo , Fitoterapia , Transtornos do Sono-Vigília/tratamento farmacológico , Animais , Masculino , Melatonina/sangue , Camundongos Endogâmicos C3H , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/fisiopatologia
16.
Lancet Neurol ; 19(10): 849-859, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32949545

RESUMO

Dreams are experiences that occur during sleep, while we are disconnected from the environment. Thanks to recent progress in neuroimaging techniques, it is now becoming possible to relate dream features to specific patterns of brain activity. Some conditions occurring in patients with neurological disorders, such as lucid dreams and parasomnias, not only have diagnostic value, but also offer a window into the dream process. They show that dreaming is reflected in physiological signals, behaviours, and brain activity patterns, and that the body can enact dream content. Yet, the dream body can also be distinct from the real body; in their dreams, patients with congenital paraplegia can walk, those with sleep apnoea rarely suffocate, and phantom limb pain can disappear. These conditions provide valuable models for future studies investigating the mechanisms that underlie oneiric experiences.


Assuntos
Sonhos/fisiologia , Doenças do Sistema Nervoso/fisiopatologia , Fases do Sono/fisiologia , Transtornos do Sono-Vigília/fisiopatologia , Adulto , Sonhos/psicologia , Humanos , Doenças do Sistema Nervoso/epidemiologia , Doenças do Sistema Nervoso/psicologia , Sono/fisiologia , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/psicologia
17.
J Stroke Cerebrovasc Dis ; 29(10): 105160, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32912522

RESUMO

BACKGROUND AND PURPOSE: Botulinum toxin (BoNT) is a commonly used agent in the treatment of stroke-related spasticity. Sleep disorders can often be seen as a comorbidity or complication in stroke patients. Based on the data that spasticity is associated with sleep disorders, in this study, we aimed to evaluate whether sleep quality has changed in patients with stroke treated with BoNT. METHODS: Thirty five (17 female / 18 male) stroke patients with gastrocnemius and / or soleus spasticity were included in this observational cross-sectional study. In clinical evaluation before and three months after BoNT injection; for spasticity evaluation modified Ashworth scale (MAS), pain assessment visual analog scale (VAS), functional evaluation; passive joint range of motion (ROM) measurement, functional independence measurement (FIM), lower limb Brunstrom staging, life quality assessment short form-36 (SF-36) quality of life scale, and sleep quality assessment Pittsburgh sleep quality index (PSQI) scales were used. RESULTS: After the BoNT injection, there was a statistically significant decrease in MAS and VAS scores, a significant increase in passive ROM measurements, FIM, lower limb Brunstrom staging, and SF-36 physical function sub parameter. There was also a significant decrease in PSQI scores. Before and after treatment, there was no correlation found between PSQI values with pain and spasticity. However, there was a weak negative correlation between post-treatment PSQI values, passive ROM, SF-36 physical function and SF-36 physical role sub parameters (respectively: r: -0.335 p: 0.049, r: -0.364, 0.032, r: -0.404, p: 0.016). Conlusion: The results of our study suggest that BoNT, which is frequently used in the treatment of spasticity in stroke patients, has positive effects on sleep quality.


Assuntos
Inibidores da Liberação da Acetilcolina/uso terapêutico , Toxinas Botulínicas/uso terapêutico , Espasticidade Muscular/tratamento farmacológico , Músculo Esquelético/efeitos dos fármacos , Transtornos do Sono-Vigília/prevenção & controle , Sono , Acidente Vascular Cerebral/fisiopatologia , Inibidores da Liberação da Acetilcolina/efeitos adversos , Adulto , Idoso , Toxinas Botulínicas/efeitos adversos , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Espasticidade Muscular/etiologia , Espasticidade Muscular/fisiopatologia , Músculo Esquelético/fisiopatologia , Qualidade de Vida , Transtornos do Sono-Vigília/etiologia , Transtornos do Sono-Vigília/fisiopatologia , Acidente Vascular Cerebral/complicações , Resultado do Tratamento
18.
Chronobiol Int ; 37(8): 1214-1222, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32856947

RESUMO

This study aimed to investigate the relationship between chronotype preference/sleep problems and symptom severity of children with Attention Deficit Hyperactivity Disorder (ADHD) during the COVID-19 outbreak and to assess the chronotype preference/sleep problems that may play a mediating role in the relationship between the reactions to trauma and severity of ADHD symptoms. The sample of this single-center cross-sectional study consisted of 76 children with ADHD and their parents. Trauma symptoms were evaluated with the Children's Impact of Event Scale (CRIES-8); sleep habits were assessed using the Children's Sleep Habits Questionnaire (CSHQ); and chronotype was assessed using the Children's Chronotype Questionnaire (CCQ). There were significant differences in CRIES-8 and CSHQ scores between the eveningness type group and the non-eveningness type group. The CRIES-8 scores of children with ADHD were related to the CCQ and CSHQ scores and severity of ADHD symptoms. In mediation analyses, sleep problems were found to be the full mediating factor in the relationship between CRIES-8 scores and severity of ADHD symptoms and the relationship between CCQ scores and the severity of ADHD symptoms. Our findings indicate that chronotype plays an important role on the negative effects of home confinement of ADHD children during the COVID-19 outbreak. The role of the full mediator of sleep problems in the path from cognition to the behavior of young ADHD and non-ADHD children confined to the home environment during the pandemic period requires further assessment.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Betacoronavirus , Ritmo Circadiano/fisiologia , Infecções por Coronavirus/virologia , Pneumonia Viral/virologia , Transtornos do Sono-Vigília/fisiopatologia , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Criança , Infecções por Coronavirus/fisiopatologia , Estudos Transversais , Feminino , Humanos , Masculino , Pandemias , Pneumonia Viral/fisiopatologia , Transtornos do Sono-Vigília/diagnóstico
19.
IEEE Pulse ; 11(4): 8-13, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32841113

RESUMO

One of the most pernicious side effects of the COVID-19 pandemic is a steep rise in stress and mental health problems. According to a poll by the Kaiser Family Foundation, nearly half of American adults say that worry and stress about the pandemic is hurting their mental health [1]. There are plenty of factors feeding into this phenomenon. People are anxious about getting sick, grieving lost loved ones, and experiencing financial stress, parental stress, and loneliness. The pandemic places additional burdens on essential workers and people of color, both of whom are at greater risk of dying from the disease. COVID-19 itself has been linked to neurological problems as well as anxiety, depression, and sleep disorders [2].


Assuntos
Betacoronavirus , Infecções por Coronavirus , Depressão , Saúde Mental , Pandemias , Pneumonia Viral , Transtornos do Sono-Vigília , Estresse Psicológico , Adulto , Infecções por Coronavirus/economia , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/psicologia , Depressão/economia , Depressão/epidemiologia , Depressão/fisiopatologia , Depressão/psicologia , Humanos , Pandemias/economia , Pneumonia Viral/economia , Pneumonia Viral/epidemiologia , Pneumonia Viral/fisiopatologia , Pneumonia Viral/psicologia , Transtornos do Sono-Vigília/economia , Transtornos do Sono-Vigília/epidemiologia , Transtornos do Sono-Vigília/fisiopatologia , Transtornos do Sono-Vigília/psicologia , Estresse Psicológico/economia , Estresse Psicológico/epidemiologia , Estresse Psicológico/fisiopatologia , Estresse Psicológico/psicologia
20.
Med Arch ; 74(3): 210-215, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32801438

RESUMO

Introduction: Several research studies have started to investigate the health conditions of medical doctors and nurses in order to find a relationship if any between their work environment, their usually heavy duties and the result of these two parametric on patients' health. Aim: The present research study is an effort to investigate the relationship between the physical activity and sleep disorders among health care professionals, particularly among medical doctors and nurses. Methods: Participants of the study were asked to fill a questionnaire which was a mixture of other internationally accredited questionnaires regarding physical activity level as well as sleeping functions. Data were collected among 204 physicians and nurses. The statistical analysis revealed a correlation between physical activity and some aspects of sleep disorders. Results: A total number of 204 questionnaires have been distributed to medical doctors and nurses working in public hospitals in Athens Greece from the middle of February until the middle of April 2020. The hospitals were assigned by the health authorities to the fight of the pandemic of COVID 19. The majority of the participants were women 71,3% and 28,7% were men. From a total of 204 half of them were medical doctors and half of them were nurses. 43% were married, 49% were single and 8% were divorced and there were no widows. Regarding the participant nurses, 43% had a university degree and 38,4% had a technological education degree. The results of the statistical analysis showed that there are positive correlations between the level of physical activity during the daily work and the free time of the participants with parameters that are related to sleep disorders. Conclusion: The sample of the study was not a large one but nevertheless a stressful situation such as is the epidemic of COVID19 can provide useful information in order to better understand the relationship between physical activity and sleeping disorders in such working conditions.


Assuntos
Infecções por Coronavirus/epidemiologia , Exercício Físico , Médicos Hospitalares , Recursos Humanos de Enfermagem no Hospital , Estresse Ocupacional , Pneumonia Viral/epidemiologia , Transtornos do Sono-Vigília , Adulto , Atitude do Pessoal de Saúde , Betacoronavirus , Exercício Físico/fisiologia , Exercício Físico/psicologia , Feminino , Grécia/epidemiologia , Médicos Hospitalares/psicologia , Médicos Hospitalares/estatística & dados numéricos , Humanos , Masculino , Recursos Humanos de Enfermagem no Hospital/psicologia , Recursos Humanos de Enfermagem no Hospital/estatística & dados numéricos , Estresse Ocupacional/etiologia , Estresse Ocupacional/fisiopatologia , Pandemias , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/fisiopatologia , Transtornos do Sono-Vigília/psicologia , Inquéritos e Questionários , Equilíbrio Trabalho-Vida , Carga de Trabalho
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...