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1.
Clin Nucl Med ; 45(6): e301-e302, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32332312

RESUMO

The majority of glomus tumors are localized to cutaneous sites and are benign. However, extracutaneous malignant glomus tumors have been reported and are aggressive. Here, we report a case of a 45-year-old man who presented severe dysphagia, diagnosed with malignant glomus tumor of the esophagus. F-FDG PET/CT played a decisive role in several phases of the patient management offering previously unknown accuracy. It was first performed in the initial staging of local tumor extent before surgery. A year and a half after, F-FDG PET/CT helped to detect recurrence and, finally, was performed for response evaluation of several systemic therapies.


Assuntos
Neoplasias Esofágicas/diagnóstico por imagem , Fluordesoxiglucose F18 , Tumor Glômico/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Neoplasias Esofágicas/patologia , Neoplasias Esofágicas/cirurgia , Tumor Glômico/patologia , Tumor Glômico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias
2.
Dermatol Online J ; 26(1)2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-32155031

RESUMO

Glomus tumors are benign tumors of the skin. Clinically, these tumors can present as solid, painful subcutaneous nodules, frequently seen on the hand (particularly subungual region). Glomangiomyomas are the least common histological type of glomus tumor. In the literature, there are only a few glomangiomyoma cases of the forearm location. We report a patient with a painful nodule, diagnosed as glomangiomyoma. Surgical excision was performed and no recurrence was observed after 5 years' follow-up.


Assuntos
Tumor Glômico/patologia , Neoplasias Cutâneas/patologia , Adulto , Antebraço/patologia , Tumor Glômico/diagnóstico , Humanos , Masculino , Neoplasias Cutâneas/diagnóstico
3.
Br J Radiol ; 93(1110): 20191037, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32108489

RESUMO

OBJECTIVE: To determine whether the location of a small, indeterminate soft tissue mass within the subcutaneous compartment is related to its histological grade. METHODS: All Sarcoma Service referrals over a 12 month period of small (<3 cm) superficial soft tissue masses, indeterminate by MRI evaluation which subsequently underwent primary excision biopsy were included. Lesions were categorised by their anatomical location in the subcutaneous compartment. Histopathological diagnoses were categorized according to12 WHO 2013. χ2 statistical analysis was performed to determine the relationship between lesion depth and histological grade. RESULTS: The study included 43 patients, mean age 42 years (range 15-71 years). Within the subcutaneous compartment, 16 lesions were categorized as superficial, 9 lesions central and 18 lesions deep, of which 9 were non-neoplastic, 29 benign, 1 intermediate-grade and 4 malignant. Location in the deep aspect of the subcutaneous compartment was associated with a higher risk of intermediate or malignant histology (p = 0.02). CONCLUSION: The location of a small, indeterminate soft tissue mass within the subcutaneous compartment may be an indicator of histological aggressiveness. Lesions in the deep subcutaneous compartment are more likely to be intermediate-grade/malignant lesions. Therefore, if considering excision biopsy as definitive treatment, a wider margin may be appropriate. ADVANCES IN KNOWLEDGE: Small, indeterminate soft tissue masses can be aggressive and the anatomical depth within the subcutaneous tissue may be a potential indicator of histological aggressiveness.


Assuntos
Neoplasias de Tecidos Moles/diagnóstico por imagem , Tela Subcutânea/diagnóstico por imagem , Adolescente , Adulto , Idoso , Distribuição de Qui-Quadrado , Feminino , Tumor Glômico/diagnóstico por imagem , Tumor Glômico/patologia , Humanos , Lipoma/diagnóstico por imagem , Lipoma/patologia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Neoplasias da Bainha Neural/diagnóstico por imagem , Neoplasias da Bainha Neural/patologia , Neoplasias de Tecidos Moles/patologia , Tela Subcutânea/patologia , Adulto Jovem
4.
J Clin Neurosci ; 74: 232-234, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31917057

RESUMO

Among peripheral nerve sheath tumors, epineural glomus tumors represent a rare differential diagnosis for peripheral nerve schwannoma, displaying the same appearance on MRI. Here we present the case of a 68-year-old man complaining of pain in the left forearm, with paresthesias in the first three fingers. MRI demonstrated a round mass along the course of the posterior interosseous nerve with homogeneous contrast enhancement. Complete surgical removal successfully relieved the symptoms. Pathological analysis led to the diagnosis of glomus tumor of uncertain malignant potential. This is to our knowledge the first reported case of epineural glomus tumor of the radial nerve.


Assuntos
Tumor Glômico/diagnóstico , Tumor Glômico/patologia , Nervo Radial/patologia , Idoso , Diagnóstico Diferencial , Antebraço/patologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias da Bainha Neural/diagnóstico , Neoplasias da Bainha Neural/patologia , Neurilemoma/diagnóstico , Dor/diagnóstico
5.
Am J Surg Pathol ; 44(1): 55-60, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31478943

RESUMO

Pericytic tumors comprise a histologic continuum of neoplasms with perivascular myoid differentiation, which includes glomus tumors, myopericytoma, myofibroma, and angioleiomyoma. Despite their morphologic overlap, recent data suggest a dichotomy in their genetic signatures, including recurrent NOTCH gene fusions in glomus tumors and PDGFRB mutations in myofibromas and myopericytomas. Moreover, SRF-RELA fusions have been described in a subset of cellular variants of myofibroma and myopericytoma showing myogenic differentiation. Triggered by an index case of an unclassified cellular myoid tumor showing a novel SRF-ICA1L fusion we have investigated our files for cases showing similar histology and screened them using a combined approach of targeted RNA sequencing and fluorescence in situ hybridization. A fusion between SRF exon 4 and ICA1L exon 10 or 11 was identified in a total of 4 spindle cell tumors with similar clinicopathologic features. Clinically, the tumors were deep-seated and originated in the trunk or proximal lower extremity of adult patients (age range: 23 to 55 y). Histologically, the tumors were composed of cellular fascicles of monomorphic eosinophilic spindle cells showing increased mitotic activity, harboring densely hyalinized stroma, often with focal areas of necrosis. All 4 tumors had similar immunoprofiles with positivity for smooth muscle actin, calponin, and smooth muscle myosin heavy chain. Tumors were negative for desmin and caldesmon, markers often seen in SRF-RELA-positive tumors with similar morphology. Follow-up information was available in 3 patients. Two patients had no evidence of disease, 2 and 5 years after surgical resection. One patient, a 35-year-old male patient with a 19 cm deep-seated tumor with brisk mitotic activity (>20 mitoses in 10 HPF), developed lung metastases 7 years after initial diagnosis. In summary, we report a series of 4 cellular myoid tumors with novel SRF-ICA1L gene fusions, characterized by bland spindle cell fascicular growth, expression of specific smooth muscle markers, elevated mitotic activity, marked stromal hyalinization, focal coagulative necrosis, and potential for malignant behavior. Given the morphologic overlap with related cellular myopericytic tumors with SRF-RELA fusions, it is likely that SRF-ICA1L fusions define a similar subset of neoplasms composed of immature smooth muscle cells.


Assuntos
Angiomioma/genética , Angiomioma/patologia , Autoantígenos/genética , Transformação Celular Neoplásica/genética , Fusão Gênica , Tumor Glômico/genética , Tumor Glômico/patologia , Miofibroma/genética , Miofibroma/patologia , Miopericitoma/genética , Miopericitoma/patologia , Fator de Resposta Sérica/genética , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
7.
BMJ Case Rep ; 12(11)2019 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-31678923

RESUMO

Glomus tumours are atypical in extracutaneous locations and very rarely located in reproductive organs. We present an unusual case of an incidentally discovered glomus tumour arising from the testis of a 47-year-old man. The testicular occurrence of this tumour type is not only exceptionally rare but also serves to highlight the debate regarding the optimal management of incidentally discovered small testicular lesions.


Assuntos
Tumor Glômico/patologia , Neoplasias Testiculares/patologia , Diagnóstico Diferencial , Tumor Glômico/diagnóstico por imagem , Tumor Glômico/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Orquiectomia , Neoplasias Testiculares/diagnóstico por imagem , Neoplasias Testiculares/cirurgia , Ultrassonografia
9.
Orv Hetil ; 160(34): 1358-1362, 2019 Aug.
Artigo em Húngaro | MEDLINE | ID: mdl-31423832

RESUMO

Introducing the diagnostic protocol and therapy of a rare disease reviewing the worldwide literature named as vagal paraganglioma is our main target. This type is specific for women of middle age, and it is appearing as a unilateral neck mass, with or without Fontaine's sign. Giving a heavy aspect on the ear, nose and throat examination, the most important diagnostic tool is CT-angiography. Carefully looking at the size and relationship with the narrowing arteries, veins, nerves, muscles and bony structures (skull base, cervical spine), in most of the cases we choose the surgical procedure. Orv Hetil. 2019; 160(34): 1358-1362.


Assuntos
Corpos Aórticos/diagnóstico por imagem , Artérias Carótidas/diagnóstico por imagem , Tumor Glômico/diagnóstico por imagem , Paraganglioma Extrassuprarrenal/diagnóstico por imagem , Angiografia , Feminino , Tumor Glômico/patologia , Tumor Glômico/cirurgia , Humanos , Pessoa de Meia-Idade , Paraganglioma Extrassuprarrenal/patologia , Paraganglioma Extrassuprarrenal/cirurgia , Tomografia Computadorizada por Raios X
12.
J Med Vasc ; 44(4): 285-290, 2019 Jun.
Artigo em Francês | MEDLINE | ID: mdl-31213301

RESUMO

Glomous tumors are rare and benign, generally affecting the fingers. Other localizations have nevertheless been described. We report the case of a patient who presented a supra-patellar glomous tumor provoking a pain-induced limp. Magnetic resonance imaging confirmed the diagnosis. The patient underwent complete surgical resection of the tumor followed by total resolution of the pain. Glomous tumors in an atypical localization may go unnoticed, with the risk of late or erroneous diagnosis. Symptoms are easily resolved with simple resection.


Assuntos
Tumor Glômico/patologia , Neoplasias de Tecidos Moles/patologia , Biópsia , Tumor Glômico/diagnóstico por imagem , Tumor Glômico/cirurgia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/cirurgia , Resultado do Tratamento , Ultrassonografia Doppler em Cores
13.
Acta Orthop Traumatol Turc ; 53(4): 313-317, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31155303

RESUMO

Malignant glomus tumors (MGTs) are exceptional but pose diagnostic and therapeutic challenges. Wide resection is the recommended treatment method, however, no data are available concerning adjuvant therapies. We present an exceptional case of extradigital deep-seated MGT of the forearm, with an exceptional bone infiltration. Despite being treated with wide resection, the patient had an optimal functional outcome, no functional loss, no motor or sensitive deficits and has returned to his full daily activity.


Assuntos
Neoplasias Ósseas , Dissecação/métodos , Antebraço , Tumor Glômico , Neoplasias de Tecidos Moles , Ulna , Atividades Cotidianas , Neoplasias Ósseas/patologia , Neoplasias Ósseas/secundário , Terapia Combinada/métodos , Antebraço/diagnóstico por imagem , Antebraço/patologia , Antebraço/cirurgia , Tumor Glômico/patologia , Tumor Glômico/fisiopatologia , Tumor Glômico/cirurgia , Humanos , Imagem por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Radiografia/métodos , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/fisiopatologia , Neoplasias de Tecidos Moles/cirurgia , Resultado do Tratamento , Carga Tumoral , Ulna/lesões , Ulna/patologia
14.
J Int Med Res ; 47(6): 2723-2727, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31039649

RESUMO

OBJECTIVE: Primary malignant glomus tumors of the thyroid gland are a rare occurrence. METHODS: A 68-year-old man found a mass on the right side of his neck in October 2017. An X-ray examination on 9 January 2018 showed multiple round reinforced masses in both sides of the lung. Computed tomography imaging of the neck showed a low-density mass on the right side of the thyroid gland. RESULTS: The immunohistochemistry results were positive for smooth muscle actin, calponin, collagen IV, and Ki-67 60%. The patient received chemotherapy starting on 17 January 2018, 8 February 2018, and 11 March 2018. The chemotherapy drugs included ifosfamide, epirubicin, and cisplatin. However, the patient subsequently developed multiple organ failure and died in April 2018, approximately 6 months after the initial discovery of the mass in his neck. CONCLUSIONS: Primary malignant glomus tumors of the thyroid gland are rare, and examination of their pathology and immunohistochemistry is vital for making an accurate final diagnosis. This case also indicates that primary malignant glomus tumors of the thyroid gland may have a poor prognosis, despite chemotherapy.


Assuntos
Tumor Glômico/patologia , Neoplasias da Glândula Tireoide/patologia , Idoso , Evolução Fatal , Tumor Glômico/complicações , Humanos , Masculino , Neoplasias da Glândula Tireoide/complicações
15.
J Med Life ; 12(1): 30-33, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31123522

RESUMO

Glomus tumors are frequently associated with pain, tenderness and cold sensitivity. We report the diagnosis and successful surgical management of a case of a classic glomus tumor in a young woman. The clinical diagnosis was made on the basis of medical history and MRI findings. The lesion was excised via a dorsolateral subungual approach, leading to the complete resolution of symptoms. Histology confirmed the lesion to be a glomus tumor. Glomus tumors are painful subungual lesions. They produce a throbbing or lancinating local discomfort, cold-sensitivity, and severe pain following minor trauma. The diagnosis is confirmed by histology, but the clinical diagnosis is highly suggestive. Complete excision will usually relieve pain. Recurrence is common following incomplete resection.


Assuntos
Dedos/patologia , Tumor Glômico/patologia , Dor/etiologia , Adulto , Antígenos CD34/metabolismo , Proliferação de Células , Feminino , Tumor Glômico/diagnóstico por imagem , Tumor Glômico/cirurgia , Humanos , Antígeno Ki-67/metabolismo , Imagem por Ressonância Magnética , Mitose , Polegar/diagnóstico por imagem , Polegar/cirurgia
16.
J Int Med Res ; 47(6): 2746-2753, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31079513

RESUMO

OBJECTIVE: Spinal involvement of glomus tumors is extremely rare. We herein present a case of a spinal glomus tumor and reviewed the literature to identify the most effective surgical treatment of spinal glomus tumors. METHODS: A 48-year-old man presented with a huge paravertebral space-occupying lesion. In this report, we present the diagnostic process and surgical procedure in this case and review the literature of glomus tumors with spine involvement. RESULTS: We suspected a primary diagnosis of neurilemmoma based on the imaging results; however, the postoperative pathologic examination confirmed a glomus tumor. Considering the size of the tumor and involvement of surrounding areas, we performed complete tumor resection and unilateral fusion with pedicle screws at the T2 to T4 level. This unilateral approach with fixation was less invasive than the standard open posterior approaches that are used when one side of the spinal canal is intact without bony destruction. CONCLUSIONS: Surgical resection is a suitable treatment for most symptomatic glomus tumors. For most glomus tumors with spine involvement, total tumor resection with suitable internal fixation and fusion is recommended.


Assuntos
Tumor Glômico/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Neoplasias da Coluna Vertebral/cirurgia , Neoplasias Torácicas/cirurgia , Tumor Glômico/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Neoplasias da Coluna Vertebral/patologia , Neoplasias Torácicas/patologia
18.
Gen Thorac Cardiovasc Surg ; 67(11): 991-995, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30799520

RESUMO

The behavior of the pathological subtypes of tracheal glomus tumor (benign, uncertain malignant potential UMP, malignant) is vague. In a 51-year-old gentleman, suffering from cough for 4 months, computed tomography scan showed a mass at lower third of the trachea and the bronchoscope revealed exophytic mass at the tracheal lumen. Segmental tracheal resection was done using special modified endotracheal tube for the distal lung ventilation. The tracheal glomus tumor was also diagnosed based on the immunohistochemical staining. The tumor was 2 cm in diameter, deeply located, mitotic phase was difficult to identify, and a diagnosis of UMP subtype was made. There was no recurrence after 2 years follow-up. This is the first reported case of UMP subtype in lower trachea and we studied the treatment options with the clinic-pathological behavior of this tumor and its sequel by regular follow-up.


Assuntos
Tumor Glômico/patologia , Tumor Glômico/cirurgia , Neoplasias da Traqueia/patologia , Neoplasias da Traqueia/cirurgia , Tumor Glômico/diagnóstico por imagem , Humanos , Intubação Intratraqueal/instrumentação , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X , Neoplasias da Traqueia/diagnóstico por imagem
19.
Eur J Radiol ; 112: 93-105, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30777226

RESUMO

Although the nail is a small anatomical structure, it can be affected by various tumors and tumor-like conditions. Because of the distinctive nail anatomy, the clinical presentation of tumors is modified, thus rendering the diagnosis challenging. As nail biopsy and surgery are painful procedures associated with an increased risk of permanent onychodystrophy, pre-operative diagnosis is desirable. Although conventional radiographs are still the first-line radiologic examination for the assessment of bony structures beneath the nail matrix, they do not allow detailed evaluation of the phalangeal soft tissues. High resolution MRI allows accurate detection and mapping of nail lesions and can suggest a specific diagnosis. This review focuses on high resolution MRI of nail tumors and tumor-like lesions. We review the nail anatomy and the optimal MRI protocol. We then discuss a variety of tumors and tumor-like lesions in relation to the clinical presentation, anatomic location, histological features and imaging characteristics. We herewith describe common benign tumors (glomus tumor, onychomatricoma, keratoakanthoma, fibroma, subungual exostosis, hemangioma, chondroma, pyogenic granuloma), malignant tumors (subungual melanoma, subungual squamous cell carcinoma), as well as tumor mimics (mucoid cyst, epidermoid cyst). Although not entirely specific, MRI is a valuable tool in treatment planning of these tumors.


Assuntos
Doenças da Unha/patologia , Neoplasias Cutâneas/patologia , Biópsia , Neoplasias Ósseas/patologia , Carcinoma de Células Escamosas/patologia , Condroma/patologia , Exostose/patologia , Fibroma/patologia , Tumor Glômico/patologia , Hemangioma/patologia , Humanos , Imagem por Ressonância Magnética/métodos , Melanoma/patologia , Cisto Sinovial/patologia
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