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2.
Altern Ther Health Med ; 27(1): 11, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33609090

RESUMO

No Abstract Available.


Assuntos
Medicina , Náusea , Feminino , Humanos , Gravidez , Vômito
4.
Neuron ; 109(3): 391-393, 2021 02 03.
Artigo em Inglês | MEDLINE | ID: mdl-33539771

RESUMO

Area postrema in brainstem has long been known to trigger emesis by detecting blood-borne toxins and pathogens. In this issue, Zhang and colleagues provide a single-cell molecular atlas of this region, opening new possibilities for harnessing its neurons in vivo.


Assuntos
Área Postrema , Náusea , Tronco Encefálico , Humanos , Neurônios , Vômito
5.
Ann R Coll Surg Engl ; 103(2): e50-e52, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33559554

RESUMO

Appendix-associated hernias are extremely rare. They have been described sporadically in the literature, mostly as inguinal hernias. Appendix-associated incisional hernias are even more unusual. High clinical awareness is needed as complications can arise if misdiagnosis or delay occurs. We present an 80-year-old man with acute appendicitis in an incisional hernia. After successful surgery, the patient made a full recovery.


Assuntos
Apendicectomia , Apendicite/diagnóstico , Herniorrafia/efeitos adversos , Hérnia Incisional/diagnóstico , Doenças Raras/diagnóstico , Dor Abdominal/etiologia , Parede Abdominal/cirurgia , Idoso de 80 Anos ou mais , Apendicite/etiologia , Apendicite/cirurgia , Apêndice/diagnóstico por imagem , Apêndice/cirurgia , Hérnia Inguinal/cirurgia , Humanos , Hérnia Incisional/etiologia , Hérnia Incisional/cirurgia , Masculino , Náusea/etiologia , Doenças Raras/etiologia , Doenças Raras/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Vômito/etiologia
6.
BMJ Case Rep ; 14(1)2021 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-33408101

RESUMO

Highly active antiretroviral therapy (HAART) has dramatically lowered rates of mother-to-child HIV transmission among patients with access to treatment. Barriers to complete viral suppression increase rates of transmission, even with only low levels of viral replication. Here, we present the case of a pregnant patient who developed a detectable viral load in pregnancy, thought to be related to calcium supplement consumption or emesis while using a dolutegravir-based HAART regimen. Ultimately, with adjustments, the patient again reached an undetectable viral load and had an uncomplicated perinatal and neonatal outcome. We discuss new data on the use of dolutegravir in pregnancy and precautions for maintaining viral suppression while on antiretroviral therapy in pregnancy.


Assuntos
Fármacos Anti-HIV/farmacologia , Terapia Antirretroviral de Alta Atividade/métodos , Infecções por HIV/tratamento farmacológico , Medicamentos sem Prescrição/farmacologia , Complicações Infecciosas na Gravidez/tratamento farmacológico , Adulto , Fármacos Anti-HIV/uso terapêutico , Contagem de Linfócito CD4 , Carbonato de Cálcio/farmacologia , Interações Medicamentosas , Feminino , Infecções por HIV/sangue , Infecções por HIV/transmissão , Infecções por HIV/virologia , HIV-1/isolamento & purificação , Humanos , Transmissão Vertical de Doença Infecciosa/prevenção & controle , Gravidez , Complicações Infecciosas na Gravidez/virologia , Carga Viral/efeitos dos fármacos , Vitaminas/farmacologia , Vômito/induzido quimicamente
7.
BMJ Case Rep ; 14(1)2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-33472809

RESUMO

Acute abdominal pain is a common presentation to the emergency department (ED). Ruling out life-threatening causes and giving pain relief are the most important tasks in ED. We describe a 32-year-old man who presented to ED with abdominal pain and vomiting which was unrelieved by usual doses of analgesic. Extensive investigations revealed no significant abnormalities. On further probing, he admitted taking traditional medications for infertility. The toxicological panel revealed a high blood lead level, leading to a diagnosis of acute lead toxicity. Chelation therapy with D-penicillamine was initiated and the patient's abdominal pain resolved within 4 days.


Assuntos
Dor Abdominal/diagnóstico , Medicamentos Falsificados/efeitos adversos , Intoxicação por Chumbo/diagnóstico , Charlatanismo , Vômito/diagnóstico , Dor Abdominal/tratamento farmacológico , Dor Abdominal/etiologia , Doença Aguda , Adulto , Anemia/etiologia , Antieméticos/uso terapêutico , Quelantes/uso terapêutico , Clordiazepóxido/uso terapêutico , Antagonistas Colinérgicos , Constipação Intestinal/etiologia , Medicamentos Falsificados/química , Combinação de Medicamentos , Serviço Hospitalar de Emergência , Humanos , Intoxicação por Chumbo/complicações , Intoxicação por Chumbo/tratamento farmacológico , Masculino , Parassimpatolíticos/uso terapêutico , Penicilamina/uso terapêutico , Fenetilaminas/uso terapêutico , Quinuclidinas/uso terapêutico , Tomografia Computadorizada por Raios X , Vômito/tratamento farmacológico , Vômito/etiologia
8.
Rev. enferm. UFPE on line ; 15(1): [1-14], jan. 2021. ilus, tab
Artigo em Português | BDENF - Enfermagem | ID: biblio-1145789

RESUMO

Objetivo: verificar o efeito da acupuntura no controle de náuseas e vômitos em pacientes submetidos à quimioterapia. Método: trata-se de um estudo bibliográfico, descritivo, tipo revisão integrativa da literatura, entre 2008 a 2018, na BVS (Biblioteca Virtual de Saúde) e na MEDLINE via PUBMED. Analisaram-se os artigos pela leitura reflexiva e criteriosa acerca das principais informações e elementos que compõem a temática nos estudos. Resultados: resultaram-se 15 artigos em inglês, espanhol e português. Percebeu-se que o efeito da acupuntura no controle de náuseas e vômitos induzidos pela quimioterapia foi satisfatório em 13 dos 15 estudos que compuseram esta revisão, mostrando uma diminuição desses sintomas durante e após o tratamento. Destacaram-se, entre os métodos evidenciados nos estudos, a acupuntura clássica e a eletroacupuntura. Conclusão: avalia-se que a acupuntura é uma prática integrativa e complementar aos tratamentos convencionais na oncologia, pois melhora a qualidade de vida dos pacientes em tratamento quimioterápico.(AU)


Objective: to verify the effect of acupuncture on the control of nausea and vomiting in patients undergoing chemotherapy. Method: this is a bibliographic, descriptive, integrative literature review type study, between 2008 and 2018, at the VHL (Virtual Health Library) and at MEDLINE via PUBMED. The articles were analyzed by a reflexive and careful reading about the main information and elements that make up the theme in the studies. Results: the result was 15 articles in English, Spanish and Portuguese. It was noticed that the effect of acupuncture in the control of nausea and vomiting induced by chemotherapy was satisfactory in 13 of the 15 studies that composed this review, showing a decrease in these symptoms during and after treatment. Among the methods evidenced in the studies, classical acupuncture and electroacupuncture were highlighted. Conclusion: acupuncture is considered an integrative practice and complementary to conventional treatments in oncology, because it improves the quality of life of patients in chemotherapy treatment.


Objetivo: verificar el efecto de la acupuntura en el control de náuseas y vómitos en pacientes sometidos a quimioterapia. Método: se trata de una revisión bibliográfica, descriptiva, integradora de la literatura, entre 2008 y 2018, en la BVS (Virtual Health Library) y MEDLINE vía PUBMED. Los artículos fueron analizados mediante una lectura reflexiva y atenta sobre las principales informaciones y elementos que componen el tema de los estudios. Resultados: se publicaron 15 artículos en inglés, español y portugués, se notó que el efecto de la acupuntura en el control de náuseas y vómitos inducidos por quimioterapia fue satisfactorio en 13 de los 15 estudios que componen esta revisión, mostrando una disminución de estos síntomas durante y después del tratamiento. Entre los métodos evidenciados en los estudios se destacaron la acupuntura clásica y la electroacupuntura. Conclusión: se evalúa que la acupuntura es una práctica integradora y complementaria a los tratamientos convencionales en oncología, ya que mejora la calidad de vida de los pacientes sometidos a quimioterapia.(AU)


Assuntos
Humanos , Masculino , Feminino , Qualidade de Vida , Vômito/prevenção & controle , Terapia por Acupuntura , Eletroacupuntura , Acupressão , Acupuntura Auricular , Náusea/prevenção & controle , Neoplasias/tratamento farmacológico , Antineoplásicos/efeitos adversos , Antineoplásicos/uso terapêutico , Epidemiologia Descritiva , MEDLINE
9.
Cir Pediatr ; 34(1): 3-8, 2021 Jan 01.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33507637

RESUMO

OBJECTIVE: To describe our experience in the diagnostic and therapeutic management of patients with acute abdomen as the main manifestation of SARS-CoV-2 infection. MATERIAL AND METHODS: A descriptive study of patients with clinical signs of acute abdomen diagnosed with COVID-19 and admitted at out healthcare facility from April 1 to May 10, 2020 was carried out. Clinical records were reviewed for data collection purposes. RESULTS: A series of 14 patients (9 male and 5 female) with a median age of 9.5 years was analyzed. All patients had abdominal pain. There were 11 patients with fever, 9 patients with vomit or diarrhea, and 9 patients with clinically suspected surgical pathology (acute appendicitis or peritonitis). Increased acute phase reactants and coagulation disorders were a common characteristic at blood tests. An abdominal ultrasonography was carried out in all patients, and a CT-scan was performed in 4 patients, which demonstrated inflammatory signs in the terminal ileum, the ileocecal valve and the ascending colon, as well as gallbladder edema. Conservative management was decided upon in all patients except one, and eight patients required intensive care admission for support treatment. CONCLUSIONS: Gastrointestinal symptoms can be the primary manifestation of the new coronavirus infection, which simulates an acute abdomen with a potentially unfavorable evolution. For an accurate diagnosis to be achieved, a good clinical record and a comprehensive physical exploration, as well as complementary tests in search of characteristic findings of COVID-19, should be carried out.


Assuntos
Abdome Agudo/diagnóstico , Dor Abdominal/etiologia , /diagnóstico , Abdome Agudo/cirurgia , Abdome Agudo/virologia , Dor Abdominal/virologia , Adolescente , Apendicite/diagnóstico , Criança , Pré-Escolar , Diarreia/epidemiologia , Diarreia/etiologia , Feminino , Febre/epidemiologia , Febre/etiologia , Humanos , Unidades de Terapia Intensiva/estatística & dados numéricos , Masculino , Peritonite/diagnóstico , Estudos Retrospectivos , Vômito/epidemiologia , Vômito/etiologia
10.
BMJ Case Rep ; 14(1)2021 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-33495170

RESUMO

It is recognised that infective endocarditis is frequently a challenging diagnosis to make, as it may present with a range of non-specific symptoms. A middle-aged man was admitted with an 8-day history of profuse non-bloody diarrhoea and vomiting. He had no medical history and no identifiable risk factors for infective endocarditis, and so this in combination with the patient's atypical symptoms presented a diagnostic challenge. The patient was eventually diagnosed with a Staphylococcus aureus right-sided infective endocarditis. This case report explores the events which led to this diagnosis and demonstrates a number of unique learning points. It also highlights the importance of maintaining an open mind and being prepared to revise an initial diagnosis in the face of medical uncertainty.


Assuntos
Bacteriemia/diagnóstico , Disenteria/diagnóstico , Endocardite Bacteriana/diagnóstico por imagem , Pneumonia/diagnóstico , Embolia Pulmonar/diagnóstico por imagem , Insuficiência da Valva Tricúspide/diagnóstico por imagem , Bacteriemia/complicações , Hemocultura , Proteína C-Reativa , Diagnóstico Diferencial , Diarreia/fisiopatologia , Escore de Alerta Precoce , Ecocardiografia , Endocardite Bacteriana/complicações , Endocardite Bacteriana/fisiopatologia , Humanos , Hipóxia , Ácido Láctico , Leucocitose , Masculino , Pessoa de Meia-Idade , Embolia Pulmonar/etiologia , Infecções Estafilocócicas , Insuficiência da Valva Tricúspide/etiologia , Vômito/fisiopatologia
11.
BMJ Case Rep ; 14(1)2021 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-33462013

RESUMO

SARS-CoV-2 is the cause of COVID-19. Since the outbreak and rapid spread of COVID-19, it has been apparent that the disease is having multi-organ system involvement. Still its effect in the endocrine system is not fully clear and data on cortisol dynamics in patients with COVID-19 are not yet available. SARS-CoV-2 can knock down the host's cortisol stress response. Here we present a case of a 51-year-old man vomiting for 10 days after having confirmed COVID-19 infection. He had hypotension and significant hyponatraemia. Work-up was done including adrenocorticotropic hormone stimulation test. He was diagnosed as suffering from adrenal insufficiency and started on steroids with subsequent improvement in both blood pressure and sodium level. COVID-19 can cause adrenal insufficiency. Clinicians must be vigilant about the possibility of an underlying relative cortisol deficiency in patients with COVID-19.


Assuntos
Insuficiência Adrenal/fisiopatologia , Hiponatremia/fisiopatologia , Hipotensão/fisiopatologia , Acidose/sangue , Acidose/fisiopatologia , Acidose/terapia , Insuficiência Adrenal/sangue , Insuficiência Adrenal/diagnóstico , Insuficiência Adrenal/tratamento farmacológico , Hidratação , Glucocorticoides/uso terapêutico , Humanos , Hidrocortisona/sangue , Hiponatremia/sangue , Hiponatremia/terapia , Hipofosfatemia/sangue , Hipofosfatemia/fisiopatologia , Hipofosfatemia/terapia , Hipotensão/terapia , Masculino , Pessoa de Meia-Idade , Testes de Função Adreno-Hipofisária , Prednisolona/uso terapêutico , Vômito/fisiopatologia , Desequilíbrio Hidroeletrolítico/sangue , Desequilíbrio Hidroeletrolítico/fisiopatologia , Desequilíbrio Hidroeletrolítico/terapia
12.
Emerg Infect Dis ; 27(2): 517-528, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33496240

RESUMO

The lack of population health surveillance for companion animal populations leaves them vulnerable to the effects of novel diseases without means of early detection. We present evidence on the effectiveness of a system that enabled early detection and rapid response a canine gastroenteritis outbreak in the United Kingdom. In January 2020, prolific vomiting among dogs was sporadically reported in the United Kingdom. Electronic health records from a nationwide sentinel network of veterinary practices confirmed a significant increase in dogs with signs of gastroenteric disease. Male dogs and dogs living with other vomiting dogs were more likely to be affected. Diet and vaccination status were not associated with the disease; however, a canine enteric coronavirus was significantly associated with illness. The system we describe potentially fills a gap in surveillance in neglected populations and could provide a blueprint for other countries.


Assuntos
Infecções por Coronavirus/veterinária , Coronavirus Canino , Surtos de Doenças , Doenças do Cão/epidemiologia , Vômito/veterinária , Animais , Doenças do Cão/virologia , Cães/virologia , Reino Unido/epidemiologia
13.
J Med Case Rep ; 15(1): 13, 2021 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-33455574

RESUMO

BACKGROUND: Invasive mole is a subtype of gestational trophoblastic neoplasms (GTNs) that usually develops from the malignant transformation of trophoblastic tissue after molar evacuation. Invasive moles mostly occur in women of reproductive age, while they are extremely rare in postmenopausal women. CASE PRESENTATION: We present the case of a 55-year-old postmenopausal Syrian woman who was admitted to the emergency department at our hospital due to massive vaginal bleeding for 10 days accompanied by constant abdominal pain with diarrhea and vomiting. Following clinical, laboratory and radiological examination, total hysterectomy with bilateral salpingo-oophorectomy was performed. Histologic examination of the resected specimens revealed the diagnosis of an invasive mole with pulmonary metastases that were diagnosed by chest computed tomography (CT). Following surgical resection, the patient was scheduled for combination chemotherapy. However, 2 weeks later the patient was readmitted to the emergency department due to severe hemoptysis and dyspnea, and later that day the patient died in spite of resuscitation efforts. CONCLUSION: Although invasive moles in postmenopausal women have been reported previously, we believe our case is the first reported from Syria. Our case highlights the difficulties in diagnosing invasive moles in the absence of significant history of gestational trophoblastic diseases. The present study further reviews the diagnostic methods, histological characteristics and treatment recommendations.


Assuntos
Mola Hidatiforme Invasiva/patologia , Neoplasias Pulmonares/secundário , Pós-Menopausa , Neoplasias Uterinas/patologia , Dor Abdominal/etiologia , Diarreia , Dispneia/etiologia , Evolução Fatal , Feminino , Hemoptise/etiologia , Humanos , Mola Hidatiforme Invasiva/diagnóstico , Mola Hidatiforme Invasiva/secundário , Mola Hidatiforme Invasiva/cirurgia , Histerectomia , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/diagnóstico , Pessoa de Meia-Idade , Gravidez , Salpingo-Ooforectomia , Síria , Tomografia Computadorizada por Raios X , Hemorragia Uterina/etiologia , Neoplasias Uterinas/complicações , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/cirurgia , Vômito
14.
BMC Infect Dis ; 21(1): 54, 2021 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-33435906

RESUMO

BACKGROUND: An outbreak of acute gastroenteritis occurred in a kindergarten located Shenzhen City on March 4, 2018. We were invited to investigate to the risk factors associated with this outbreak. METHODS: We conducted retrospective cohort-studies on three different groups of subjects in order to figure out the difference of incidence of acute gastroenteritis among subjects of different activities on March 2: group one consisted of people who attended the Lantern festival activities; group two consisted of children and employees who ate breakfast and bread provided by the kindergarten; and groups three consisted of children and employees who did not eat breakfast or bread provided by the kindergarten. Fecal, anal swabs, dishware swabs and hand swabs specimens were collected in the study. Bacteria known to cause acute gastroenteritis were cultured. Viruses associated with acute gastroenteritis were tested using real-time PCR. Capsid gene fragment of 557 bp of norovirus was amplified and sequenced. The phylogenetic tree was constructed with MEGA 7.0 using neighbor-joining method based on capsid gene fragment of norovirus. RESULTS: A total of 143 suspected cases were identified in this outbreak. Diarrhea happened more often in adults than in children while emesis and bellyache were more frequently found in children than in adults. Higher AGE incidence was observed in group 2, children and employees who had breakfast in the kindergarten on March 2, as well as in group 3, and among employees who eating bread involved in breakfast provided on March 2. Five anal swab specimens were positive for norovirus. All noroviruses belongs to group II.3 and have an identity more than 99%. CONCLUSION: A chef, as an asymptomatic carrier with norovirus, was the infectious resource in this outbreak. He contaminated breakfast food provided on March 2. Although morning check is implemented in kindergartens of China, employees are often excluded in morning check. Our finding highlights the importance of morning check covering employees and periodical training for cooks.


Assuntos
Desjejum , Infecções por Caliciviridae/epidemiologia , Portador Sadio/virologia , Surtos de Doenças , Manipulação de Alimentos , Gastroenterite/epidemiologia , Norovirus/genética , Escolas Maternais , Adulto , Infecções por Caliciviridae/diagnóstico , Infecções por Caliciviridae/prevenção & controle , Infecções por Caliciviridae/virologia , Criança , Pré-Escolar , China/epidemiologia , Diarreia/epidemiologia , Diarreia/virologia , Fezes/virologia , Feminino , Microbiologia de Alimentos/métodos , Gastroenterite/diagnóstico , Gastroenterite/prevenção & controle , Gastroenterite/virologia , Humanos , Incidência , Masculino , Filogenia , Quarentena/métodos , Reação em Cadeia da Polimerase em Tempo Real , Estudos Retrospectivos , Fatores de Risco , Vômito/epidemiologia , Vômito/virologia
19.
Support Care Cancer ; 29(1): 213-222, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32338316

RESUMO

PURPOSE: To compare rates of complete response (no emesis, retching, or rescue antiemetics) in the late phase (days 4-7 post-chemotherapy) of cycle 1 between transdermal granisetron and oral ondansetron in cervical, endometrial, or vaginal cancer survivors undergoing chemoradiation at The University of Texas MD Anderson Cancer Center and LBJ Hospital in Houston, TX. METHODS: In this non-blinded parallel design trial, eligible patients received a granisetron patch replaced every 7 days or 8 mg of ondansetron thrice daily continued for 72 h after chemotherapy completion. Data were collected on medication compliance, episodes of chemotherapy-induced nausea and vomiting (CINV), use of rescue antiemetics, and effects of CINV on quality of life. RESULTS: Seventy-five survivors receiving chemoradiation for cervical (n = 61), endometrial (n = 12), or vaginal (n = 2) cancer were electronically randomized to transdermal granisetron (n = 41) or oral ondansetron (n = 34). In the late phase of cycle 1, the rate of complete response was 49.8% (95% CI, 35.2-64.3%) for transdermal granisetron and 39.7% (95% CI, 24.4-56.1%) for oral ondansetron. The posterior probability that transdermal granisetron achieved a higher success rate in controlling late-onset CINV compared with oral ondansetron was 82%. During the acute phase (day 1 post-chemotherapy) of cycles 2 and 3, transdermal granisetron patients used more rescue antiemetics than oral ondansetron patients (p = 0.006 and p = 0.003, respectively). Otherwise, no between-group differences in CINV events were observed. Medication compliance and the effect of CINV on quality of life were similar between groups. CONCLUSION: Transdermal granisetron was 82% more like to control CINV than oral ondansetron in the late phase of cycle 1 and performed similarly to oral ondansetron in all other cycles. Transdermal granisetron should be considered an option as prophylactic antiemetic therapy for gynecologic cancer survivors undergoing chemoradiation.


Assuntos
Antieméticos/uso terapêutico , Antineoplásicos/efeitos adversos , Granisetron/uso terapêutico , Náusea/prevenção & controle , Ondansetron/uso terapêutico , Vômito/prevenção & controle , Administração Cutânea , Adulto , Antineoplásicos/uso terapêutico , Sobreviventes de Câncer/estatística & dados numéricos , Neoplasias do Endométrio/tratamento farmacológico , Feminino , Granisetron/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Náusea/induzido quimicamente , Náusea/tratamento farmacológico , Ondansetron/administração & dosagem , Qualidade de Vida/psicologia , Indução de Remissão , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias Vaginais/tratamento farmacológico , Vômito/induzido quimicamente , Vômito/tratamento farmacológico
20.
BMJ Case Rep ; 13(12)2020 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-33370983

RESUMO

One of the causes of congenital incomplete duodenal obstruction is the presence of congenital duodenal web with fenestration. This condition requires a high index of suspicion for an early and accurate diagnosis. We present an unusual presentation of duodenal web in a 6-year-old girl who presented with a 3-year history of cyclical and seasonal vomiting and abdominal pain. The diagnosis of congenital duodenal web with fenestration was made on contrast study and endoscopy and was treated surgically by incision of the web.


Assuntos
Dor Abdominal/etiologia , Obstrução Duodenal/diagnóstico , Duodeno/anormalidades , Vômito/etiologia , Dor Abdominal/cirurgia , Criança , Obstrução Duodenal/congênito , Obstrução Duodenal/cirurgia , Duodeno/cirurgia , Endoscopia , Feminino , Humanos , Fatores de Tempo , Resultado do Tratamento , Vômito/cirurgia
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