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1.
Bone Joint J ; 102-B(10): 1375-1383, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32993330

RESUMO

AIMS: To investigate metallosis in patients with magnetically controlled growing rods (MCGRs) and characterize the metal particle profile of the tissues surrounding the rod. METHODS: This was a prospective observational study of patients with early onset scoliosis (EOS) treated with MCGRs and undergoing rod exchange who were consecutively recruited between February 2019 and January 2020. Ten patients were recruited (mean age 12 years (SD 1.3); 2 M:8 F). The configurations of the MCGR were studied to reveal the distraction mechanisms, with crucial rod parts being the distractable piston rod and the magnetically driven rotor inside the barrel of the MCGR. Metal-on-metal contact in the form of ring-like wear marks on the piston was found on the distracted portion of the piston immediately outside the barrel opening (BO) through which the piston rod distracts. Biopsies of paraspinal muscles and control tissue samples were taken over and away from the wear marks, respectively. Spectral analyses of the rod alloy and biopsies were performed to reveal the metal constituents and concentrations. Histological analyses of the biopsies were performed with haematoxylin and eosin staining. RESULTS: Titanium (Ti), vanadium (V), and neodymium (Nd) concentrations in the biopsies taken near the wear marks were found to be significantly higher than those in the control tissue samples. Significantly increased Nd concentrations were also found in the tissues near the barrel of the MCGR. Chronic inflammation was revealed by the histological studies with fibrosis and macrophage infiltration. Black particles were present within the macrophages in the fibrotic tissues. CONCLUSION: Ti and V were generated mainly at the BO due to metal-on-metal contact, whereas the Nd from the rotor of the MCGR is likely released from the BO during distraction sessions. Phagocytotic immune cells with black particles inside raise concern regarding the long-term implications of metallosis. Cite this article: Bone Joint J 2020;102-B(10):1375-1383.


Assuntos
Reação a Corpo Estranho/etiologia , Próteses e Implantes/efeitos adversos , Escoliose/cirurgia , Biópsia , Criança , Feminino , Reação a Corpo Estranho/diagnóstico por imagem , Humanos , Magnetismo , Masculino , Neodímio/efeitos adversos , Estudos Prospectivos , Escoliose/diagnóstico por imagem , Titânio/efeitos adversos , Vanádio/efeitos adversos
2.
Poult Sci ; 99(3): 1705-1716, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32115038

RESUMO

Vanadium (V) is an ultratrace metal with the insulin-tropic properties and is often researched as the diabetes drug. However, in animals, V has been reported to have toxic effects on the development, immunity, oxidation-reduction equilibrium, gastrointestinal function, and so forth. Especially in poultry, supplementation of more than 10 mg of V/kg in the layer diets has been shown to adversely affect the egg production and egg quality. In this study, we supplemented 0 mg of V/kg, 5 mg of V/kg, and 10 mg of V/kg in the layer diets for 35 D and examined the quantitative proteomics of albumen for finding the possible target signaling pathway and mechanism of V action and made the preliminary verification. In contrast to the control group, V resulted in a significant drop in the albumen height, and in oviduct ampulla, the activity of total antioxidant capacity and glutathione peroxidase significantly decreased (P = 0.01, P = 0.02), the content of malonic dialdehyde significantly increased (P = 0.01), and the apoptosis rate significantly increased in the 5-mg V/kg and 10-mg V/kg treatment groups (P < 0.01). V affected 36 differentially accumulated proteins in albumen, with 23 proteins upregulated and 13 proteins downregulated. The expressions of innate protein albumen lysozyme (Q6LEL2), vitellogenin-2 (P02845), and the F1NWD0 protein in albumen belonged to the P53 family were significantly reduced, in contrast to the control (P < 0.05), and the expression of riboflavin-binding protein (P02752) was significantly improved (P < 0.05). The Hippo signaling pathway-fly, which is suitable for the key protein P53 as the most significantly affected network, might be important for discriminating V.


Assuntos
Ração Animal/análise , Clara de Ovo/análise , Proteoma , Vanádio/efeitos adversos , Animais , Galinhas , Dieta/veterinária , Proteínas do Ovo/química , Feminino , Oviductos , Transdução de Sinais
3.
Brain Res Bull ; 145: 75-80, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-29577939

RESUMO

Vanadium, atomic number 23, is a transition metal widely distributed in nature. It is a major contaminant of fossil fuels and is widely used in industry as catalysts, in welding, and making steel alloys. Over the years, vanadium compounds have been generating interests due to their use as therapeutic agents in the control of diabetes, tuberculosis, and some neoplasms. However, the toxicity of vanadium compounds is well documented in literature with occupational exposure of workers in vanadium allied industries, environmental pollution from combustion of fossil fuels and industrial exhausts receiving concerns as major sources of toxicity and a likely predisposing factor in the aetiopathogenesis of neurodegenerative diseases. A lot has been done to understand the neurotoxic effects of vanadium, its mechanisms of action and possible antidotes. Sequel to our review of the subject in 2011, this present review is to detail the recent insights gained in vanadium neurotoxicity.


Assuntos
Síndromes Neurotóxicas/etiologia , Vanádio/efeitos adversos , Vanádio/toxicidade , Animais , Encéfalo/metabolismo , Encéfalo/fisiologia , Humanos , Síndromes Neurotóxicas/fisiopatologia , Compostos de Vanádio/efeitos adversos , Compostos de Vanádio/toxicidade
4.
J Peripher Nerv Syst ; 24(1): 94-99, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30488528

RESUMO

Depletion of myelin and neurobehavioural deficits are indications that vanadium crosses the blood-brain barrier and such neurotoxic effects of vanadium on the brain of Wistar rats have been elucidated. The effect however on the peripheral nerves, is yet to be reported. Thus, this work was designed to evaluate the axonal and myelin integrity of sciatic nerves in Wistar rats following exposure to vanadium. Ten male Wistar rats were exposed to 3 mg/kg body weight of sodium metavanadate for 7 days, subjected to rearing and forelimb grip behavioural tests, and sciatic nerves processed for histology (haematoxylin and eosin, cresyl violet, and luxol fast blue). Dystrophic axons with vesiculated myelin, thinned myelin sheath, and demyelinated axons were observed in the vanadium exposed rats, suggestive of axonopathy, classified as fourth-degree nerve injury. Lower behavioural scores were recorded for vanadium-dosed rats; thus, corroborating histological pictures observed of the sciatic nerves. Authors posit that vanadium crossed the "blood-nerve" barrier and caused the observed axonal pathologies and myelin depletion in the sciatic nerves of these rodents with resultant motor deficits. The present paper discusses possible motor deficits and the likely public health importance in regions with crude oil pollution and gas flaring rich in vanadium products.


Assuntos
Axônios/efeitos dos fármacos , Comportamento Animal/efeitos dos fármacos , Barreira Hematoencefálica/efeitos dos fármacos , Bainha de Mielina/efeitos dos fármacos , Síndromes Neurotóxicas/etiologia , Nervo Isquiático/efeitos dos fármacos , Oligoelementos/efeitos adversos , Vanádio/efeitos adversos , Animais , Axônios/patologia , Modelos Animais de Doenças , Masculino , Síndromes Neurotóxicas/patologia , Ratos Wistar , Nervo Isquiático/patologia
6.
Lancet Planet Health ; 2(10): e427-e437, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30318100

RESUMO

BACKGROUND: Identification of windows of heightened vulnerability to environmental factors has substantial public health implications. Prenatal exposure to vanadium has been linked to adverse birth outcomes; however, critical windows for such exposure during fetal growth remain unknown. We aimed to assess trimester-specific associations of vanadium exposure with ultrasound measures of fetal growth and birth size in a Chinese longitudinal cohort. METHODS: The present study was embedded in our ongoing prospective prenatal cohort study at the Wuhan Women and Children Medical Care Center (Wuhan, Hubei, China). Pregnant women were eligible for inclusion if they provided signed informed consent and were less than 16 weeks pregnant with a single gestation, and agreed to take in-person interviews, undergo ultrasound examinations, and provide blood and urine samples. We collected urine samples and measured urinary vanadium concentrations using inductively coupled plasma mass spectrometry. We calculated SD scores for ultrasound-measured biparietal diameter, head circumference, occipitofrontal diameter, abdominal circumference, femur length, and estimated fetal weight at 16, 24, and 31 weeks of gestation. We applied linear regressions with generalised estimating equations to estimate associations of urinary vanadium concentrations in each trimester with ultrasound-measured fetal growth parameters or neonatal size at birth. FINDINGS: As of Oct 12, 2016, we recruited 3075 women who were non-smokers and non-drinkers during pregnancy, provided up to three urine samples during the first, second, and third trimesters, and gave birth to live singletons without birth defects. We excluded women who did not provide information on ultrasound measurements (n=20) or who only had one ultrasound measurement of fetal crown-rump length at the first trimester (n=14). We excluded another 16 women because they had missing values for confounding variables, leaving 3025 women retained in the study. Every doubling of urinary vanadium concentration in the first trimester was associated with a significant increase in femur length (adjusted percentage change 6·4%, 95% CI 0·7 to 12·1) at 16 weeks of gestation and reductions in biparietal diameter (-4·2%, -8·2 to -0·1), head circumference (-6·0%, -10·1 to -1·9), occipitofrontal diameter (-5·7%, -9·9 to -1·5), and abdominal circumference (-5·3%, -9·4 to -1·2) at 31 weeks of gestation. Every doubling of urinary vanadium concentration in the second trimester was significantly associated with reductions in SD scores for head circumference (-7·2%, -14·1 to -0·3) and abdominal circumference (-6·9%, -13·8 to -0·1) at 31 weeks of gestation. The highest quartile of urinary vanadium concentration (>1·18 µg/L) in the first trimester, when compared with the lowest quartile (≤0·60 µg/L), was associated with a mean decrease in birthweight of 12·6 g (95% CI 2·5-22·8; ptrend=0·0055) and a mean decrease in ponderal index of 0·07 kg/m3 (0·01-0·12; ptrend=0·0053). Moreover, newborns with restricted birth size had higher vanadium exposure in the first and third trimesters. INTERPRETATION: Vanadium might be toxic to humans and impair fetal growth. The first, early second, and late third trimesters could be critical windows for heightened vulnerability to vanadium for fetal growth. Our findings require further investigation in other populations. FUNDING: National Key R&D Plan of China, National Natural Science Foundation of China, and Fundamental Research Funds for the Central Universities, Huazhong University of Science and Technology.


Assuntos
Peso ao Nascer/efeitos dos fármacos , Poluentes Ambientais/efeitos adversos , Desenvolvimento Fetal/efeitos dos fármacos , Exposição Materna/efeitos adversos , Trimestres da Gravidez/efeitos dos fármacos , Vanádio/efeitos adversos , Adulto , China , Relação Dose-Resposta a Droga , Feminino , Humanos , Estudos Longitudinais , Masculino , Dinâmica não Linear , Gravidez , Estudos Prospectivos , Ultrassonografia Pré-Natal , Adulto Jovem
7.
Chemosphere ; 210: 1035-1041, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30208528

RESUMO

Heavy metal exposure has been indicated to be linked with reproductive and developmental toxicity. However, human studies on the association between heavy metal exposure and premature rupture of membranes (PROM) are limited. Thus, we aimed to evaluate the associations between urinary metal concentrations in pregnant women and the risk of PROM. The study was conducted among 7290 pregnant women from an ongoing cohort study in China. Levels of urinary metals were determined using an inductively coupled plasma-mass spectrometry and adjusted by creatinine concentration (µg/g creatinine). Adjusted odds ratios (OR) and 95% confidence intervals (CI) for PROM and preterm PROM were estimated using logistic regression models. Among 12 urinary metals detected, vanadium (V) have shown stable positive associations with PROM and preterm PROM. With one unit increase in natural logarithmically transformed urinary V concentration, adjusted OR of 1.57 (95% CI: 1.47, 1.66) for PROM was observed. Compared with the lowest tertile of urinary V, we also observed positive associations between V levels and PROM (for the medium tertile, adjusted OR = 1.66, 95% CI: 1.34, 2.05; for the highest tertile, adjusted OR = 3.75, 95% CI: 3.09, 4.54). In addition, higher adjusted ORs for preterm PROM were observed (for the highest tertile, adjusted OR = 8.14, 95% CI: 4.55, 14.55). Further stratified analysis suggested the associations were more pronounced among women delivering male infants than those with female infants. Our present epidemiological study indicated that pregnant women exposure to higher level of V might lead to an increased risk of PROM.


Assuntos
Ruptura Prematura de Membranas Fetais/etiologia , Ruptura Prematura de Membranas Fetais/urina , Exposição Materna/efeitos adversos , Nascimento Prematuro/epidemiologia , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Vanádio/efeitos adversos , Vanádio/urina , Adulto , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Gravidez , Nascimento Prematuro/induzido quimicamente , Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente
8.
Biol Trace Elem Res ; 186(1): 52-67, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29524196

RESUMO

Ultra-trace elements or occasionally beneficial elements (OBE) are the new categories of minerals including vanadium (V). The importance of V is attributed due to its multifaceted biological roles, i.e., glucose and lipid metabolism as an insulin-mimetic, antilipemic and a potent stress alleviating agent in diabetes when vanadium is administered at lower doses. It competes with iron for transferrin (binding site for transportation) and with lactoferrin as it is secreted in milk also. The intracellular enzyme protein tyrosine phosphatase, causing the dephosphorylation at beta subunit of the insulin receptor, is inhibited by vanadium, thus facilitating the uptake of glucose inside the cell but only in the presence of insulin. Vanadium could be useful as a potential immune-stimulating agent and also as an antiinflammatory therapeutic metallodrug targeting various diseases. Physiological state and dose of vanadium compounds hold importance in causing toxicity also. Research has been carried out mostly on laboratory animals but evidence for vanadium importance as a therapeutic agent are available in humans and large animals also. This review examines the potential biochemical and molecular role, possible kinetics and distribution, essentiality, immunity, and toxicity-related study of vanadium in a biological system.


Assuntos
Vanádio , Animais , Glucose/metabolismo , Humanos , Cinética , Vanádio/efeitos adversos , Vanádio/metabolismo , Vanádio/farmacocinética
9.
BMJ Case Rep ; 20182018 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-29351933

RESUMO

Allergic reactions to metals following joint arthroplasty represent a rare and poorly understood phenomenon. Much is still unknown regarding the natural history of this complication, and how it can best be prevented and managed. We present a case of a 68-year-old woman who underwent a left total knee arthroplasty for treatment of osteoarthritis. After an initial uneventful postoperative course, she developed a troublesome erythematous rash both around the incision site and over her trunk. Blood testing revealed no evidence of infection and clinically her prosthesis was functioning well. Skin patch testing revealed positive results for vanadium (+) and palladium (+). Her cutaneous symptoms are currently being managed conservatively and have shown a partial response to topical steroids. Revision surgery remains a long-term treatment option should conservative therapy fail; however, it would require a custom-made prosthesis as no standard tibial component is free from vanadium.


Assuntos
Artroplastia do Joelho/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Articulação do Joelho/cirurgia , Osteoartrite/cirurgia , Esteroides/administração & dosagem , Vanádio/imunologia , Administração Tópica , Idoso , Artroplastia do Joelho/instrumentação , Dermatite Alérgica de Contato/etiologia , Exantema , Feminino , Humanos , Articulação do Joelho/fisiopatologia , Prótese do Joelho/efeitos adversos , Osteoartrite/fisiopatologia , Testes do Emplastro , Desenho de Prótese , Amplitude de Movimento Articular/fisiologia , Resultado do Tratamento , Vanádio/efeitos adversos
10.
J Plant Physiol ; 220: 115-127, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29172132

RESUMO

Vanadium (V) is an important heavy metal with ubiquitous presence in the Earth's crust, but limited information is available as to its effect on plants and management strategies. Melatonin is a widely studied biomolecule; it acts as an antioxidant and a signaling molecule that enhances the abiotic stress tolerance of plants. Melatonin improves copper, zinc, and cadmium tolerance in plants. In this study, we investigated the response of watermelon seedlings to V stress and the potential role of melatonin in enhancing V stress tolerance of watermelon seedlings. The results showed that seedlings pretreated with melatonin (0.1µM) exposed to V (50mg/L) had a higher relative chlorophyll content (SPAD index), photosynthetic assimilation, and plant growth compared with non-melatonin pretreated seedlings. Melatonin pretreatment lowered leaf and stem V concentrations by reducing V transport from root to shoot. Melatonin pretreatment enhanced superoxide dismutase (SOD) and catalase (CAT) activities, and reduced the hydrogen peroxide (H2O2) and malondialdehyde (MDA) content of watermelon seedlings, by regulating melatonin biosynthesis and gene expression for superoxide dismutase, peroxidase, ascorbate peroxidase, glutathione peroxidase, and glutathione S-transferase. So far as we know, these results are the first evidence that melatonin improves plant growth of watermelon seedlings under vanadium stress conditions. Considering these observations, melatonin can be utilized to reduce the availability of V to plants, and improve plant growth and V stress tolerance.


Assuntos
Antioxidantes/metabolismo , Citrullus/efeitos dos fármacos , Regulação da Expressão Gênica de Plantas , Expressão Gênica , Melatonina/metabolismo , Proteínas de Plantas/genética , Vanádio/efeitos adversos , Antioxidantes/administração & dosagem , Citrullus/genética , Citrullus/crescimento & desenvolvimento , Melatonina/administração & dosagem , Folhas de Planta/efeitos dos fármacos , Folhas de Planta/crescimento & desenvolvimento , Folhas de Planta/metabolismo , Proteínas de Plantas/metabolismo , Plântula/efeitos dos fármacos , Plântula/crescimento & desenvolvimento , Estresse Fisiológico
11.
Proc Natl Acad Sci U S A ; 114(52): E11092-E11100, 2017 12 26.
Artigo em Inglês | MEDLINE | ID: mdl-29229856

RESUMO

Synthesizing published data, we provide a quantitative summary of the global biogeochemical cycle of vanadium (V), including both human-derived and natural fluxes. Through mining of V ores (130 × 109 g V/y) and extraction and combustion of fossil fuels (600 × 109 g V/y), humans are the predominant force in the geochemical cycle of V at Earth's surface. Human emissions of V to the atmosphere are now likely to exceed background emissions by as much as a factor of 1.7, and, presumably, we have altered the deposition of V from the atmosphere by a similar amount. Excessive V in air and water has potential, but poorly documented, consequences for human health. Much of the atmospheric flux probably derives from emissions from the combustion of fossil fuels, but the magnitude of this flux depends on the type of fuel, with relatively low emissions from coal and higher contributions from heavy crude oils, tar sands bitumen, and petroleum coke. Increasing interest in petroleum derived from unconventional deposits is likely to lead to greater emissions of V to the atmosphere in the near future. Our analysis further suggests that the flux of V in rivers has been incremented by about 15% from human activities. Overall, the budget of dissolved V in the oceans is remarkably well balanced-with about 40 × 109 g V/y to 50 × 109 g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,000 y with respect to inputs from rivers.


Assuntos
Modelos Biológicos , Vanádio/química , Vanádio/metabolismo , Humanos , Vanádio/efeitos adversos
12.
J Dent ; 66: 91-101, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28800964

RESUMO

OBJECTIVES: The etiology of the reduced marginal bone loss observed around platform-switched implant-abutment connections is not clear but could be related to the release of variable amounts of corrosion products. The present study evaluated the effect of different concentrations of metal ions released from different implant abutment couples on osteoblastic cell viability, apoptosis and expression of genes related to bone resorption. METHODS: Osteoblastic cells were exposed to five conditions of culture media prepared containing metal ions (titanium, aluminum, vanadium, cobalt, chromium and molybdenum) in different concentrations representing the amounts released from platform-matched and platform-switched implant-abutment couples as a result of an earlier accelerated corrosion experiment. Cell viability was evaluated over 21days using the Alamar Blue assay. Induction of apoptosis was measured after 24h of exposure using flow cytometry. Expression of interleukin-6, interleukin-8, cyclooxygenase-2, caspase-8, osteoprotegerin and receptor activator of nuclear factor kappa-B ligand (RANKL) by osteoblastic cells were analysed after exposure for 1, 3 and 21days using real-time quantitative polymerase chain reaction assay RESULTS: Metal ions in concentrations representing the platform-matched groups led to a reduction in cell viability (P<0.01) up to 7days of exposure. Stimulated cells showed higher rates of early apoptosis (P<0.01) compared to non-treated cells. Metal ions up-regulated the expression of interleukin-6, interleukin-8, cyclooxygenase-2 and RANKL in a dose dependent manner after 1day of exposure (P<0.05). The up-regulation was more pronounced in the groups containing the corrosion products of platform-matched implant-abutment couples. CONCLUSION: Osteoblastic cell viability, apoptosis, and regulation of bone resorbing mediators were significantly altered in the presence of metal ions. The change in cytokine levels expressed was directly proportional to the metal ion concentration. CLINICAL SIGNIFICANCE: The observed biological responses to decreased amounts of metal ions released from platform-switched implant-abutment couples compared to platform-matched couples may partly explain the positive radiographic findings in respect to crestal bone level when utilising the "platform-switching" concept, which highlights the possible role of corrosion products in the mediation of crestal bone loss around dental implants.


Assuntos
Perda do Osso Alveolar/etiologia , Dente Suporte , Ligas Dentárias/efeitos adversos , Implantes Dentários , Íons/efeitos adversos , Metais/efeitos adversos , Osteoblastos/efeitos dos fármacos , Osteoblastos/metabolismo , Alumínio/efeitos adversos , Alumínio/química , Apoptose/efeitos dos fármacos , Caspase 8/metabolismo , Técnicas de Cultura de Células , Sobrevivência Celular/efeitos dos fármacos , Cromo/efeitos adversos , Cromo/química , Cobalto/efeitos adversos , Cobalto/química , Corrosão , Ciclo-Oxigenase 2/metabolismo , Ligas Dentárias/química , Projeto do Implante Dentário-Pivô , Implantação Dentária Endo-Óssea , Expressão Gênica/efeitos dos fármacos , Humanos , Interleucina-6/metabolismo , Interleucina-8/metabolismo , Molibdênio/efeitos adversos , Molibdênio/química , Osteoprotegerina/metabolismo , Ligante RANK/metabolismo , Fatores de Tempo , Titânio/efeitos adversos , Titânio/química , Vanádio/efeitos adversos , Vanádio/química
13.
Cutis ; 99(4): 245-249, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28492599

RESUMO

Allergy as a cause of adverse outcomes in patients with implanted orthopedic hardware is controversial. Allergy to titanium-based implants has not been well researched, as titanium is traditionally thought to be inert. We highlight the case of a patient who developed systemic dermatitis and implant failure after surgical placement of a titanium alloy (Ti6Al4V) plate in the left foot. The hardware was removed and the eruption cleared in the following weeks. The plate and screws were submitted for metal analysis. The elemental composition of both the plate and screws included 3 major elements-titanium, aluminum, and vanadium-as well as trace elements. Metal analysis revealed that the plate and screws had different microstructures, and electrochemical studies demonstrated that galvanic corrosion could have occurred between the plate and screws due to their different microstructures, contributing to the release of vanadium in vivo. The patient was patch tested with several metals including components of the implant and had a positive patch test reaction only to vanadium trichloride. These findings support a diagnosis of vanadium allergy and suggests that clinicians should consider including vanadium when patch testing patients with a suspected allergic reaction to vanadium-containing implants.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Fixadores Internos/efeitos adversos , Vanádio/efeitos adversos , Ligas/efeitos adversos , Placas Ósseas/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Diagnóstico Diferencial , Falha de Equipamento , Feminino , Humanos , Pessoa de Meia-Idade , Osteoartrite/cirurgia , Testes do Emplastro , Falanges dos Dedos do Pé
14.
Curr Hypertens Rep ; 19(3): 10, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28197835

RESUMO

Trace metals play an important role in the proper functioning of carbohydrate and lipid metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while deficiency of these trace metals can cause disorders with metabolic and physiological imbalances. This article concentrates on three trace metals (selenium, vanadium, and chromium) that may play crucial roles in controlling blood glucose concentrations possibly through their insulin-mimetic effects. For these trace metals, the level of evidence available for their health effects as supplements is weak. Thus, their potential is not fully exploited for the target of metabolic syndrome, a constellation that increases the risk for cardiovascular disease and type 2 diabetes. Given that the prevalence of metabolic syndrome is increasing throughout the world, a simpler option of interventions with food supplemented with well-studied trace metals could serve as an answer to this problem. The oxidation state and coordination chemistry play crucial roles in defining the responses to these trace metals, so further research is warranted to understand fully their metabolic and cardiovascular effects in human metabolic syndrome.


Assuntos
Cromo/uso terapêutico , Síndrome Metabólica/tratamento farmacológico , Micronutrientes/uso terapêutico , Selênio/uso terapêutico , Oligoelementos/uso terapêutico , Vanádio/uso terapêutico , Cromo/efeitos adversos , Suplementos Nutricionais , Humanos , Insulina/metabolismo , Micronutrientes/efeitos adversos , Selênio/efeitos adversos , Oligoelementos/efeitos adversos , Vanádio/efeitos adversos
15.
Lancet Planet Health ; 1(6): e230-e241, 2017 09.
Artigo em Inglês | MEDLINE | ID: mdl-29851608

RESUMO

BACKGROUND: Vanadium, an important pollutant produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in animal studies. However, little is known about its effects on humans. We aimed to assess the association of prenatal exposure to vanadium with the risk of adverse birth outcomes in babies born to women in China. METHODS: For this population-based cohort study, the Healthy Baby Cohort, women were recruited from three cities in Hubei Province, China. Women included in this analysis were recruited from Wuhan Women and Children Medical Care Center, Wuhan. We measured urinary concentrations of vanadium and other metals simultaneously using inductively coupled plasma mass spectrometry. We used multivariable logistic regressions, with adjustment for potential confounders, to estimate the associations of natural logarithm transformed creatinine-corrected urinary vanadium (Ln-vanadium) concentrations as continuous variables and categorised into quartiles (Q; Q1: ≤0·84 µg/g creatinine, Q2: 0·84-1·40 µg/g creatinine, Q3: 1·40-2·96 µg/g creatinine, Q4: >2·96 µg/g creatinine, with the lowest quartile set as reference) with preterm delivery, early-term delivery, low birthweight, and being small for gestational age. We applied restricted cubic spline models to evaluate the dose-response relationships. FINDINGS: Data from 7297 women recruited between Sept 22, 2012, and Oct 22, 2014, were included in this study. Urinary Ln-vanadium concentrations showed non-linear dose-response relationships with risk of preterm delivery (S-shaped, p<0·0001) and low birthweight (J-shaped, p=0·0001); the adjusted odds ratios (ORs) for increasing quartiles of urinary vanadium were 1·76 (95% CI 1·05-2·95) for Q2, 3·17 (1·96-5·14) for Q3, and 8·86 (5·66-13·86) for Q4 for preterm delivery, and 2·29 (95% CI 1·08-4·84) for Q2, 3·22 (1·58-6·58) for Q3, and 3·56 (1·79-7·10) for Q4 for low birthweight. Ln-vanadium concentrations were linearly associated with the risk of early-term delivery (linear, p<0·0001) and being small for gestational age (linear, p=0·0027), with adjusted ORs of 1·15 (95% CI 1·10-1·21) for early-term delivery and 1·12 (1·04-1·21) for being small for gestational age per unit increase in Ln-vanadium concentrations. INTERPRETATION: Our findings reveal a relationship between prenatal exposure to higher levels of vanadium and increased risk of adverse birth outcomes, suggesting that vanadium might be a potential toxic metal for human beings. Further studies are needed to replicate the observed associations and investigate the interaction effects of prenatal exposure to different metals on adverse birth outcomes. FUNDING: National Key R&D Plan of China, National Natural Science Foundation of China, and Fundamental Research Funds for the Central Universities, Key Laboratory of Environment and Health.


Assuntos
Poluentes Ambientais/efeitos adversos , Exposição Materna/efeitos adversos , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Vanádio/efeitos adversos , Adolescente , Adulto , China/epidemiologia , Estudos de Coortes , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido Pequeno para a Idade Gestacional , Masculino , Pessoa de Meia-Idade , Gravidez , Nascimento Prematuro/induzido quimicamente , Nascimento Prematuro/epidemiologia , Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente , Medição de Risco , Adulto Jovem
16.
J Immunotoxicol ; 13(4): 498-508, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27043960

RESUMO

Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after V inhalation. The effect of V on the immune system as related to sex has been poorly investigated. This study sought to determine if V inhalation (a) produced lymphoproliferation that could explain the changes previously observed in the spleen and in peripheral blood lymphocyte counts and (b) whether any observed effects differed due to gender. Immunohistochemical analyses of Ki-67, a specific proliferation marker, was made in the spleens of CD-1 male and female mice exposed for 1 h, twice a week, over a 12-week period to V2O5 (at 1.4 mg V2O5/m(3)) by whole-body inhalation; similar analyses were performed on spleens of control mice exposed to vehicle (filtered air). The results showed that in male mice there was a significant increase in percentage of Ki-67 immunopositive lymphocytes starting from the second week and until the end of the exposure. The Ki-67 signal was cytoplasmic and nuclear in the exposed males, while in controls the signal was only nuclear. In female mice, V inhalation singificantly increased the percentage of proliferating lymphocytes only after 1 week of exposure. Ki-67 signal was observed only in the nucleus of lymphocytes from the control and exposed females. The results here help to explain the splenomegaly and lymphocytosis observed previously in male mice and support the lymphoproliferative effect induced by V. Lastly, the finding that there was a sex difference in the effect of vanadium on lymphocyte proliferation suggests a role for sex hormones in potential protection against V immunotoxicity; however, further studies are needed to support this hypothesis.


Assuntos
Linfócitos/imunologia , Transtornos Linfoproliferativos/imunologia , Sexo , Compostos de Vanádio/imunologia , Vanádio/imunologia , Poluição do Ar/efeitos adversos , Animais , Proliferação de Células , Células Cultivadas , Feminino , Combustíveis Fósseis/efeitos adversos , Humanos , Inalação , Transtornos Linfoproliferativos/induzido quimicamente , Masculino , Camundongos , Camundongos Endogâmicos , Material Particulado/efeitos adversos , Material Particulado/toxicidade , Baço/patologia , Vanádio/efeitos adversos , Compostos de Vanádio/efeitos adversos
17.
Acta Med Port ; 28(3): 386-9, 2015.
Artigo em Português | MEDLINE | ID: mdl-26421793

RESUMO

INTRODUCTION: Hemolytic anemia may be associated with multiple etiologies, including toxic substances, such as metals, which is a rare cause. CASE STUDY: 55-year-old male, who underwent a total arthroplasty of the right hip (uncemented prostheses with ceramic-ceramic articulation with an acetabular component consisting of a dome composed of an alloy of titanium, aluminum and vanadium into which fitted a ceramic 'insert'). Approximately 4 years after surgery the patient complained of noise originating from the prosthesis which occurred on movement. A surgical revision was performed and showed the presence of dark thick intracapsular fluid, fracture of the ceramic acetabular 'insert' and signs of wear of the acetabular metal dome. Extensive washing was carried out and the fractured ceramic 'insert' was replaced for a polyethylene 'insert'. Two months later he was referred to the Emergency Room due to worsening of his general health, floating in the right hip and mucocutaneous jaundice. Laboratory tests suggested autoimmune hemolytic anemia. Arthrocentesis was performed and a large volume of metal fluid was drained off. The CT scan showed a large heterogeneous pelvic cystic collection seeded with prosthesis fragments, suggestive of metallosis. Hemolytic anemia was explained as toxicity of the particles and metal ions caused by the wear of the prosthesis. The patient was started on a high-dose steroid treatment. Afterwards, when he was stable, prosthesis components replacement and drainage of pelvic debris fluid were carried out. DISCUSSION: After the fracture of the ceramic 'insert' the ceramic head began to articulate directly with the metallic acetabular component, causing noise and wear with release of particles and ions. This caused a cystic pelvic abscess, which went unnoticed on the first surgical revision. Surgical debridement lead to the cystic collection extending into the adjacent tissues and the systemic circulation, triggering serious systemic effects, such as autoimmune hemolytic anemia. The potential toxicity of each of the metal elements of this prosthesis is unknown, and there are still no available laboratory tests for its detection. CONCLUSION: Metallosis is a rare cause of autoimmune hemolytic anemia.


Assuntos
Ligas/efeitos adversos , Alumínio/efeitos adversos , Anemia Hemolítica Autoimune/etiologia , Prótese de Quadril/efeitos adversos , Complicações Pós-Operatórias/etiologia , Titânio/efeitos adversos , Vanádio/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Desenho de Prótese
18.
Epidemiology ; 26(3): 300-9, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25688676

RESUMO

BACKGROUND: Ambient particulate matter (PM) exposure is associated with children's respiratory health. Little is known about the importance of different PM constituents. We investigated the effects of PM constituents on asthma, allergy, and lung function until the age of 11-12 years. METHODS: For 3,702 participants of a prospective birth cohort study, questionnaire-reported asthma and hay fever and measurements of allergic sensitization and lung function were linked with annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc in particles with diameters of less than 2.5 and 10 µm (PM2.5 and PM10) at birth addresses and current addresses from land-use regression models. Exposure-health relations were analyzed by multiple (repeated measures) logistic and linear regressions. RESULTS: Asthma incidence and prevalence of asthma symptoms and rhinitis were positively associated with zinc in PM10 at the birth address (odds ratio [95% confidence interval] per interquartile range increase in exposure 1.13 [1.02, 1.25], 1.08 [1.00, 1.17], and 1.16 [1.04, 1.30], respectively). Moreover, asthma symptoms were positively associated with copper in PM10 at the current address (1.06 [1.00, 1.12]). Allergic sensitization was positively associated with copper and iron in PM10 at the birth address (relative risk [95% confidence interval] 1.07 [1.01, 1.14] and 1.10 [1.03, 1.18]) and current address. Forced expiratory volume in 1 second was negatively associated with copper and iron in PM2.5 (change [95% confidence interval] -2.1% [-1.1, -0.1%] and -1.0% [-2.0, -0.0%]) and FEF75-50 with copper in PM10 at the current address (-2.3% [-4.3, -0.3%]). CONCLUSION: PM constituents, in particular iron, copper, and zinc, reflecting poorly regulated non-tailpipe road traffic emissions, may increase the risk of asthma and allergy in schoolchildren.


Assuntos
Asma/induzido quimicamente , Material Particulado/efeitos adversos , Rinite Alérgica Sazonal/induzido quimicamente , Asma/epidemiologia , Criança , Pré-Escolar , Cobre/efeitos adversos , Cobre/análise , Feminino , Humanos , Incidência , Lactente , Recém-Nascido , Ferro/efeitos adversos , Ferro/análise , Modelos Lineares , Modelos Logísticos , Masculino , Países Baixos/epidemiologia , Níquel/efeitos adversos , Níquel/análise , Material Particulado/química , Potássio/efeitos adversos , Potássio/análise , Prevalência , Estudos Prospectivos , Rinite Alérgica Sazonal/epidemiologia , Silício/efeitos adversos , Silício/análise , Enxofre/efeitos adversos , Enxofre/análise , Vanádio/efeitos adversos , Vanádio/análise , Zinco/efeitos adversos , Zinco/análise
19.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 46(6): 856-9, 2015 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-26867320

RESUMO

OBJECTIVE: To determine the oxidative stress level in peripheral blood of vanadium-exposed workers, as an indication of population health effect of vanadium on human neurobehavioral system. METHODS: 86 vanadium-exposed workers and 65 non-exposed workers were recruited by cluster sampling. A questionnaire was administered to collect demographic and occupational exposure information. Serum activity of superoxide dismutase (SOD), inducible nitric oxide synthase (iNOS) and malonaldehyde (MDA) contents were detected by kit assay. The differences in oxidative stress level between vanadium-exposed and non-exposed workers were compared. RESULTS: Vanadium-exposed workers had higher levels of MDA contents than the controls. The total superoxide dismutase(T-SOD) activity in vanadium-exposed workers was significantly lower than that in the controls, which was associated with lowered levels of manganese superoxide dismutase (Mn-SOD) activity. No changes in serum levels of cupro-zinc superoxide dismutase (CuZn-SOD) was found in vanadium-exposed workers. No difference in iNOS activity was found between vanadium-exposed workers and controls. CONCLUSION: Vanadium exposure increases free radical production in serum and reduces antioxidant capacity. But the relationship between vanadium exposure and iNOS damage remains uncertain.


Assuntos
Exposição Ocupacional/efeitos adversos , Estresse Oxidativo , Vanádio/efeitos adversos , Antioxidantes/metabolismo , Humanos , Malondialdeído/metabolismo , Óxido Nítrico Sintase Tipo II/metabolismo , Oxirredução , Superóxido Dismutase/metabolismo
20.
Environ Res ; 133: 266-73, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24981825

RESUMO

Throughout the last few years, the southern North Sea has witnessed an increase in the number of stranded marine mammals, particularly the harbour porpoise (Phocoena phocoena). This species is subject to several potential threats such as exposure to contaminants, changes in food supply, marine traffic and fishery by-catch. The aims of this study were to investigate potential associations between contaminants and health status and to analyze spatial and temporal trends of metal concentrations in harbour porpoises. Selected trace elements (As, Cd, Cr, Cu, Hg, Mn, Se, V and Zn) were measured in kidneys and livers of 105 harbour porpoises stranded along the southern North Sea (French and Belgian coasts from 2006 to 2013) and 27 stranded along the Bay of Biscay (French coast from 2009 to 2012). Porpoises that died from infectious disease displayed significant higher hepatic concentrations of Cd, Hg, Se and Zn compared to healthy porpoises that died from physical trauma. Adult porpoises displayed significant higher concentrations of Cd, Cr, Hg, Se and V in livers compared to juveniles. No spatial or temporal trends in metal concentrations were detected in our study. The results of the present study suggested that chemical contamination may represent one of many threats encountered by harbour porpoises, but it cannot explain alone the increase in the number of stranded individuals.


Assuntos
Poluentes Ambientais/efeitos adversos , Rim/química , Fígado/química , Metais Pesados/efeitos adversos , Phocoena , Animais , Cádmio/efeitos adversos , Causas de Morte , Feminino , Masculino , Mercúrio/efeitos adversos , Mar do Norte , Selênio/efeitos adversos , Vanádio/efeitos adversos , Zinco/efeitos adversos
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