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1.
Eur Respir Rev ; 31(163)2022 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-35022257

RESUMO

Commercially available since 2007, e-cigarettes are a popular electronic delivery device of ever-growing complexity. Given their increasing use by ex-smokers, smokers and never-smokers, it is important to evaluate evidence of their potential pulmonary effects and predict effects of long-term use, since there has been insufficient time to study a chronic user cohort. It is crucial to evaluate indicators of harm seen in cigarette use, and those potentially unique to e-cigarette exposure. Evaluation must also account for the vast variation in e-cigarette devices (now including at least five generations of devices) and exposure methods used in vivo and in vitroThus far, short-term use cohort studies, combined with in vivo and in vitro models, have been used to probe for the effects of e-cigarette exposure. The effects and mechanisms identified, including dysregulated inflammation and decreased pathogen resistance, show concerning overlaps with the established effects of cigarette smoke exposure. Additionally, research has identified a signature of dysregulated lipid processing, which is unique to e-cigarette exposure.This review will evaluate the evidence of pulmonary effects of, and driving mechanisms behind, e-cigarette exposure, which have been highlighted in emerging literature, and highlight the gaps in current knowledge. Such a summary allows understanding of the ongoing debate into e-cigarette regulation, as well as prediction and potential mitigation of future problems surrounding e-cigarette use.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Humanos , Estudos Longitudinais , Fumantes , Vaping/efeitos adversos
2.
Medicina (B Aires) ; 82(1): 151-153, 2022.
Artigo em Espanhol | MEDLINE | ID: mdl-35037875

RESUMO

Vaping is considered to be the inhalation of aerosols generated by heating liquids. There are devices freely marketed for vaping, with electronic cigarettes being the most common. These products are associated with the appearance of lung injury, either vaping-induced lung injury (VAPI), or lung injury associated with vaping and electronic cigarettes (EVALI). We presented the case of a 54-year-old woman with a history of vaping in the last 9 months. She consulted for acute dyspnea (class IV) associated with nausea and vomiting of 18 hours of evolution. Upon admission, she presented respiratory failure. Orotracheal intubation was performed with mechanical ventilatory assistance. A chest tomography revealed bilateral diffuse alveolar infiltrates. The clinical picture was interpreted as VAPI/EVALI. The exact pathophysiology of vaping-induced lung injury is still unknown; dyspnea and cough are the most frequent symptoms. All patients have pathological radiological images. Respiratory support and systemic corticosteroids are the treatment of choice.


Se considera vapeo a la inhalación de aerosoles generados por el calentamiento de líquidos. Existen dispositivos que se comercializan libremente para realizar vapeo, siendo los cigarrillos electrónicos los más frecuentes. Estos productos están asociados a la aparición de injuria pulmonar, ya sea injuria pulmonar inducida por vapeo (VAPI), o injuria pulmonar asociada a vapeo y cigarrillos electrónicos (EVALI). Se presenta el caso de una mujer de 54 años con antecedentes de vapeo en los últimos 9 meses. Consultó por disnea clase funcional IV asociada a náuseas y vómitos de 18 h de evolución. Al ingreso presentó insuficiencia respiratoria. Se realizó intubación orotraqueal con asistencia ventilatoria mecánica; la tomografía de tórax evidenció infiltrados alveolares difusos bilaterales. Se interpretó el cuadro clínico como VAPI/EVALI. Aún se desconoce la fisiopatogenia exacta de la injuria pulmonar inducida por vapeo; la disnea y tos son los síntomas más frecuentes. Todos los pacientes tienen imágenes radiológicas patológicas. El soporte respiratorio y los corticoides sistémicos son el tratamiento de elección.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Lesão Pulmonar , Insuficiência Respiratória , Vaping , Dispneia , Feminino , Humanos , Lesão Pulmonar/induzido quimicamente , Lesão Pulmonar/diagnóstico por imagem , Pessoa de Meia-Idade , Vaping/efeitos adversos
3.
South Med J ; 115(1): 8-12, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34964053

RESUMO

Before the coronavirus disease 2019 (COVID-19) pandemic, vaping-related illness was the prevailing public health concern. The incidence of vaping-related illnesses-mainly e-cigarette, or vaping, product use-associated lung injury (EVALI)-went from a peak in September 2019 to a low in February 2020, and the Centers for Disease Control and Prevention decided to discontinue the collection of EVALI case reports. Despite the decrease in EVALI with the arrival of COVID-19, EVALI should still be considered a differential diagnosis for people with COVID-19 for reasons outlined in this review. This narrative review describes vaping devices, summarizes the adverse health effects of vaping on the lungs and other systems, considers the potential interplay between vaping and COVID-19, and highlights gaps in knowledge about vaping that warrant further research.


Assuntos
COVID-19/prevenção & controle , Vaping/efeitos adversos , COVID-19/psicologia , Humanos , Lesão Pulmonar/epidemiologia , Lesão Pulmonar/etiologia , Vaping/tendências
5.
BMJ Case Rep ; 14(12)2021 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-34920999

RESUMO

Vaping may lead to spontaneous pneumothorax, but there are few published reports on this phenomenon. We present a case of vaping-related pneumothorax and make recommendations for structured reporting of this emerging cause for pneumothorax. A normal-weight 34-year-old male presented to our emergency department with dyspnoea and back pain increasing over 24 hours. Chest X-ray showed a large right-sided pneumothorax. Three years ago, he had quit smoking cigarettes and switched to vaping. CT scan revealed bullae, and the patient received apical lung resection. Histology revealed mild alveolitis. Vaping is an emerging cause of lung injury. This report demonstrates a potential association between vaping and pneumothorax. However, structured reporting and future research are needed to establish a definitive (or causal) relationship between vaping and pneumothorax.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Pneumotórax , Vaping , Adulto , Humanos , Masculino , Pneumotórax/diagnóstico por imagem , Pneumotórax/etiologia , Vaping/efeitos adversos
6.
Artigo em Inglês | MEDLINE | ID: mdl-34948812

RESUMO

The COVID-19 pandemic generated large amounts of stress across the globe. While acute stress negatively impacts health, defining exact consequences and behavioral interventions can be difficult. We hypothesized that a generalized increase in stress and anxiety caused by continuation of the global pandemic would negatively impact sleep quality and that ever users of e-cigarettes and conventional tobacco would have more profound alterations over time. Participants were recruited via social media to complete an online survey in April 2020 (n = 554). Inhalant use was assessed through the UCSD Inhalant Questionnaire and sleep quality was gauged through the Pittsburgh Sleep Quality Index (PSQI). A set of participants (n = 217) retook the survey in June 2020. Inhalant users-historical or current e-cigarette vapers, conventional tobacco smokers, and dual users-had higher PSQI scores than never smoker/never vapers, demonstrating worse sleep quality in inhalant users. Non-smoking/non-vaping subjects who retook the survey in June 2020 had improvement in their PSQI scores by paired t test, indicating better sleep quality as the pandemic continued, while inhalant users of all types had persistently high PSQI scores (poor sleep quality). These data suggest that ever users of tobacco products may be susceptible to overall diminished sleep quality in the setting of stressful life circumstances. These data also suggest that pandemic-initiated lifestyle changes may have led to improvements in sleep quality. Finally, these findings raise concerns for correlations between either past or active e-cigarette use on sleep, and thus overall health.


Assuntos
COVID-19 , Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Estudos Transversais , Humanos , Pandemias , SARS-CoV-2 , Vaping/efeitos adversos
7.
N C Med J ; 82(6): 384-392, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34750211

RESUMO

BACKGROUND In August 2019, the North Carolina Division of Public Health (NCDPH) began investigating e-cigarette, or vaping, product use-associated lung injury (EVALI) cases as part of a national response. We describe clinical, epidemiologic, and laboratory findings of North Carolina EVALI patients.METHODS NCDPH requested that physicians report cases of respiratory illness or bilateral pulmonary infiltrates or opacities in patients who reported using e-cigarette, or vaping, products and had no infection or alternative plausible diagnoses. We reviewed medical records, interviewed patients, and tested vaping products for substances.RESULTS During August 13, 2019-February 18, 2020, 78 EVALI cases were reported in North Carolina. Median age of cases was 24 years (range: 13-72 years); 49 (63%) patients were male. Symptoms included cough (n = 70; 90%), shortness of breath (n = 66; 85%), and gastrointestinal symptoms (n = 63; 81%). Seventy-five patients (96%) were hospitalized, 32 (41%) required intensive care, and 12 (16%) required mechanical ventilation; none died. Among 20 patients interviewed, most reported using tetrahydrocannabinol (THC) (n = 16; 80%) or nicotine-containing products (n = 14; 70%). All obtained THC-containing products from informal sources, such as family, friends, or dealers, as THC is illegal in North Carolina. Among 82 products tested, 74 (90%) contained THC, cannabidiol, or cannabinol; 54 (66%) contained vitamin E acetate.LIMITATIONS In North Carolina, EVALI is not reportable by law, and THC is illegal. Thus, cases and exposures are likely underreported.CONCLUSIONS THC-containing products, particularly those containing vitamin E acetate, are associated with EVALI. Persons should not use these products, particularly from informal sources. Continued communication of health risks to persons who use e-cigarette, or vaping, products is essential.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Lesão Pulmonar , Vaping , Adolescente , Adulto , Idoso , Surtos de Doenças , Humanos , Lesão Pulmonar/epidemiologia , Masculino , Pessoa de Meia-Idade , North Carolina/epidemiologia , Vaping/efeitos adversos , Adulto Jovem
8.
Clin Dermatol ; 39(5): 762-771, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34785004

RESUMO

Cigarette and electronic cigarette use are significant public health concerns across the United States. Tobacco use remains the single most preventable cause of morbidity and mortality in the world. Electronic cigarettes initially emerged as a better alternative to conventional cigarettes and for promoting smoking cessation; however, current evidence reveals similar deleterious health implications caused by both products on almost all organ systems, including the skin. Recognition of the cutaneous manifestations associated with cigarette and electronic cigarette use is essential for dermatologists in current clinical practice. Dermatologists play a vital role in educating and counseling patients on smoking cessation. We specifically highlight the cutaneous consequences of conventional cigarette smoking and electronic cigarettes on dermatologic disease.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Produtos do Tabaco , Vaping , Humanos , Tabaco , Uso de Tabaco , Estados Unidos/epidemiologia , Vaping/efeitos adversos
9.
WMJ ; 120(3): 205-208, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34710302

RESUMO

INTRODUCTION: In light of increased rates of hospitalizations among adolescents diagnosed with severe symptoms of COVID-19, as well as the prevalence of electronic vaping product (EVP) use among this population, this review highlights the public health and clinical implications of EVP use during an ongoing respiratory disease pandemic. OBJECTIVES: This review assesses evidence of pulmonary effects of EVP use from pathophysiological and epidemiological research and explores EVP use as a risk factor for COVID-19. METHODS: An updated, yet concise, literature review of recent scientific evidence examining trends of EVP use among adolescents during the COVID-19 pandemic was conducted. Included in this review are studies examining the pulmonary effects of EVP use and scope of the problem relating to its use among adolescents within the context of COVID-19. CONCLUSIONS: Preclinical and theoretical models establish pulmonary harm associated with EVPs. Based on the limited epidemiological studies, the contribution of EVP use to the risk of contracting COVID-19 is mixed. EVP-associated lung injury could present as a diagnostic challenge for clinicians during COVID-19 and requires greater attention. Clinicians should effectively screen for and discourage EVP use among adolescents.


Assuntos
COVID-19 , Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Adolescente , Eletrônica , Humanos , Pandemias , SARS-CoV-2 , Vaping/efeitos adversos
10.
Compr Physiol ; 11(4): 2621-2644, 2021 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-34661289

RESUMO

Electronic cigarettes (e-cigs) are used by millions of adolescents and adults worldwide. Commercial e-liquids typically contain flavorants, propylene glycol, and vegetable glycerin with or without nicotine. These chemical constituents are detected and evaluated by chemosensory systems to guide and modulate vaping behavior and product choices of e-cig users. The flavorants in e-liquids are marketing tools. They evoke sensory percepts of appealing flavors through activation of chemical sensory systems to promote the initiation and sustained use of e-cigs. The vast majority of flavorants in e-liquids are volatile odorants, and as such, the olfactory system plays a dominant role in perceiving these molecules that enter the nasal cavity either orthonasally or retronasally during vaping. In addition to flavorants, e-cig aerosol contains a variety of by-products generated through heating the e-liquids, including odorous irritants, toxicants, and heavy metals. These harmful substances can directly and adversely impact the main olfactory epithelium (MOE). In this article, we first discuss the olfactory contribution to e-cig flavor perception. We then provide information on MOE cell types and their major functions in olfaction and epithelial maintenance. Olfactory detection of flavorants, nicotine, and odorous irritants and toxicants are also discussed. Finally, we discuss the cumulated data on modification of the MOE by flavorant exposure and toxicological impacts of formaldehyde, acrolein, and heavy metals. Together, the information presented in this overview may provide insight into how e-cig exposure may modify the olfactory system and adversely impact human health through the alteration of the chemosensory factor driving e-cig use behavior and product selections. © 2021 American Physiological Society. Compr Physiol 11:2621-2644, 2021.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Adolescente , Aerossóis , Aromatizantes/toxicidade , Humanos , Nicotina/toxicidade , Estados Unidos , Vaping/efeitos adversos
11.
Artigo em Inglês | MEDLINE | ID: mdl-34639705

RESUMO

BACKGROUND: E-cigarette use (vaping) is an emerging public health problem. Depression has been found to be associated with e-cigarette use, and vaping and depression are each associated with elevated systemic inflammation. To date, the role of inflammation in the relationship between vaping and depression has not been explored. OBJECTIVE: To assess the independent associations between e-cigarette use, depression, and inflammation, and to investigate whether the likelihood of depression among current e-cigarette users is associated with systemic inflammation. METHODS: Nationally representative NHANES data from 2015-2018 were used (n = 4961). Systemic inflammation was defined as serum C-reactive protein (CRP) ≥ 8.0 mg/L. Depressed individuals were characterized by a score ≥ 10 on the Patient Health Questionnaire-9 (PHQ-9). Current e-cigarette users were defined as individuals who vaped at least once in the past 30 days and these individuals were stratified by use: exclusive users (reported smoking less than 100 combustible cigarettes in their lifetime), dual users (reported current use of electronic and combustible cigarettes), and e-cigarette users who were previous smokers. Bivariate analyses were used to assess independent associations between vaping, depression, and inflammation; and weighted logistic regression analyses adjusting for BMI, sex, and economic status were used to determine the odds ratios (ORs) for depression by e-cigarette category stratified by differential CRP levels. RESULTS: Depression occurred in 16.7% of all e-cigarette users vs. 5.0% of those who never used e-cigarettes (p < 0.001). In adjusted analyses, the following elevated ORs were found: all current e-cigarette users with CRP <8 = 3.37 (95% CI: 2.06, 5.51) vs. CRP ≥8 = 6.70 (2.48, 18.11); exclusive e-cigarette users with CRP <8 = 1.91 (0.78, 4.69) vs. those with CRP ≥8 = 5.09 (1.44, 18.02); and dual users with CRP <8 = 4.31 (2.35, 7.89) vs. those with CRP ≥8 = 7.37 (1.85, 29.41). These ORs indicate that depression is associated with each category of e-cigarette use; however, we found this association did not vary by systemic inflammation level (interaction p-values > 0.05). CONCLUSION: While a pattern of greater ORs for depression among e-cigarette users with elevated CRP provides provocative findings that might suggest a potential role of inflammation in the association between vaping and depression, we failed to find evidence that inflammation clearly moderates this association. While it is possible that depression among e-cigarette users may be influenced by systemic inflammation, a reproduction of the current study is necessary among a larger cohort to elucidate the effect of inflammation on depression among e-cigarette users.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Depressão/epidemiologia , Humanos , Inflamação/epidemiologia , Inquéritos Nutricionais , Vaping/efeitos adversos
12.
Mo Med ; 118(5): 450-452, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34658439

RESUMO

The prevalence of electronic cigarette use is increasing at an astonishing pace, particularly in the teenage population. While at school, a healthy 13-year-old male experienced a sudden cardiac arrest after vaping multiple times throughout the day. Workup revealed an anomalous left coronary artery originating from the right sinus of Valsalva. Given this patient's underlying anomalous left coronary artery, we suspect that sympathoexcitatory and arrhythmogenic effects of high dose nicotine from vaping led to his cardiovascular collapse. This is the first published case report of a vaping associated cardiac arrest in a patient of this age.


Assuntos
Artéria Coronária Esquerda Anormal , Anomalias dos Vasos Coronários , Sistemas Eletrônicos de Liberação de Nicotina , Parada Cardíaca , Seio Aórtico , Vaping , Adolescente , Anomalias dos Vasos Coronários/complicações , Anomalias dos Vasos Coronários/diagnóstico por imagem , Parada Cardíaca/etiologia , Humanos , Masculino , Instituições Acadêmicas , Vaping/efeitos adversos
14.
Int J Cardiol ; 343: 146-148, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34506824

RESUMO

INTRODUCTION: Vaping emerges as alternative to standard tobacco smoking. However, there is evidence for critical cardiovascular, gastrointestinal and respiratory side effects. Nevertheless, long-term vaping effects on thrombocyte reactivity have not been investigated. Therefore, we investigated the influence of vaping on thrombocyte reactivity in comparison to standard smoking and non-smoking. METHODS: Platelet function was measured by Multiplate Impedance Aggregometry as area under the curve (AUC). Smoking habits and characteristics were assessed by questionnaire. Results were analyzed using inverse probability of treatment weighting (IPTW) and conventional t-tests to test for robustness. RESULTS: After IPTW adjustment, participants in all groups were balanced by age, gender, body height and weight. Collagen-induced aggregation was higher in vapers compared to non-smokers (non-smokers 52.55 ± 23.97 vs. vapers 66.63 ± 18.96 AUC, p = 0.002) and to smokers (vapers vs. smokers 49.50 ± 26.05 AUC, p < 0.0001). ADP-induced aggregation in vapers was higher compared to non-smokers (non-smokers 33.16 ± 16.61 vs. vapers 45.27 ± 18.67 AUC, p = 0.001) and was numerically increased compared to smokers (vapers vs. smokers 40.09 ± 19.80 AUC, p = 0.08). These findings remained robust in t-test analysis. CONCLUSION: This study provides first evidence that vaping leads to enhanced platelet reactivity compared to standard smoking and non-smoking. This suggests health effects of vaping might be more severe than previously assumed. Whether this effect translates to clinical outcome with a higher incidence of major cardiovascular events, should be evaluated in large-scaled clinical studies.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Vaping , Plaquetas , Humanos , Fumantes , Inquéritos e Questionários , Vaping/efeitos adversos
16.
Artigo em Inglês | MEDLINE | ID: mdl-34360495

RESUMO

The US Centers for Disease Control and Prevention alerted of a suspected outbreak of lung illness associated with using E-cigarette products in September 2019. At the time that the CDC published its alert little was known about the causes of the outbreak or who was at risk for it. Here we provide insights into the outbreak through analysis of passive reporting and participatory surveillance. We collected data about vaping habits and associated adverse reactions from four data sources pertaining to people in the USA: A participatory surveillance platform (YouVape), Reddit, Google Trends, and Bing. Data were analyzed to identify vaping behaviors and reported adverse events. These were correlated among sources and with prior reports. Data was obtained from 720 YouVape users, 4331 Reddit users, and over 1 million Bing users. Large geographic variation was observed across vaping products. Significant correlation was found among the data sources in reported adverse reactions. Models of participatory surveillance data found specific product and adverse reaction associations. Specifically, cannabidiol was found to be associated with fever, while tetrahydrocannabinol was found to be correlated with diarrhea. Our results demonstrate that utilization of different, complementary, online data sources provide a holistic view of vaping associated lung injury while augmenting traditional data sources.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Lesão Pulmonar , Vaping , Surtos de Doenças , Humanos , Internet , Estados Unidos/epidemiologia , Vaping/efeitos adversos
17.
Artigo em Inglês | MEDLINE | ID: mdl-34360499

RESUMO

The purpose of this study is to evaluate the association of electronic nicotine product (ENP) use and its respiratory manifestations in a nationally representative sample of adolescents in the US. Cross-sectional evidence from 9750 adolescents in wave 3 (October 2015-October 2016) of the Population Assessment of Tobacco and Health (PATH) survey was used. Adjusting for demographics, lifetime number of cigarettes and cigars used, home rules about tobacco use, and tobacco used by other household members, we used logistic regression models to examine associations between ENP use and its respiratory manifestations in the past year. Among 9750 adolescents, 12% (n = 1105) used ENP in the past year. Compared to non-users, past-year ENP-users had 37% higher odds of wheezing in general (Adjusted Odds Ratio (AOR) = 1.37, 95% Confidence interval (CI): 1.11-1.71, p = 0.005) and higher odds of wheezing 4-12 times or >12 times per year versus no wheezing (AOR = 1.57, 95% CI: 1.01-2.46, p = 0.05 and AOR = 2.58, 95% CI: 1.04-6.41, p = 0.04, respectively). Additionally, odds of dry cough at night were 23% higher among ENP-users than among non-users (AOR = 1.23, 95% CI: 1.04-1.46, p = 0.02). There was no association between past-year ENP use and exercise-induced wheezing or asthma diagnosis. Among those with asthma, there was no evidence of an association between ENP use and long-acting inhaler or quick-relief inhaler use. ENP use among adolescents is associated with increased frequency of wheezing and dry cough. Early recognition of pulmonary clinical manifestations among young ENP users should be critical considerations in regulatory and prevention efforts to protect public health, and clinical efforts to prevent progression to serious pulmonary complications.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Produtos do Tabaco , Vaping , Adolescente , Estudos Transversais , Humanos , Tabaco , Estados Unidos/epidemiologia , Vaping/efeitos adversos
19.
S D Med ; 74(7): 318-321, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34449994

RESUMO

Vaping quickly rose in popularity once introduced to the market in 2003. Devices heat liquid to produce an aerosol that is inhaled by the user, an aerosol that can contain nicotine, heavy metals, volatile organic compounds, ultrafine particles, cancer-causing chemicals, and flavoring. Teenagers commonly use these products to smoke cannabinoids including delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and butane hash oil (BHO). Liquids placed in the devices can be commercial or homemade. As popularity increased, more cases of vaping-related lung injury have been reported. We report a case of a 17-year-old female patient with delayed diagnosis of e-cigarette or vaping associated lung injury.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Lesão Pulmonar , Vaping , Adolescente , Butanos , Feminino , Humanos , Lesão Pulmonar/induzido quimicamente , Vaping/efeitos adversos
20.
Artigo em Inglês | MEDLINE | ID: mdl-34444050

RESUMO

Web-based samples of e-cigarette users commonly report significant vaping-related health improvements (HIs) and mild adverse events (AEs). This cross-sectional study with in-person interviewing data collection examined self-reported AEs and perceived HIs among Hungarian adult current daily exclusive e-cigarette (n = 65) and dual users (n = 127), and former daily e-cigarette users (n = 91) in 2018. Logistic regression was used to evaluate associations between reporting any AEs/HIs, vaping status, and covariates. More former users (52.7%) reported AEs than current users (39.6%; p = 0.038). Exclusive and dual daily users reported similar rates of AEs (44.6% and 37.0%, respectively; p = 0.308). More current users (46.9%) experienced HIs than former users (35.2%; p = 0.064). Exclusive daily users were more likely to report HIs than dual users (63.1% versus 38.6%; p = 0.001). Former user status and smoking cessation/reduction reasons increased the odds of reporting AEs, whereas nicotine-containing e-liquid use and older age decreased the odds of reporting AEs. Exclusive vaper status, using advanced generation devices, and smoking cessation/reduction reasons increased the odds of experiencing HIs. This study, which used a traditional data collection methodology, found a higher rate of AEs and a lower rate of HIs compared to web-based surveys. Our results highlight that experiencing AEs and HIs is affected by users' characteristics, in addition to the device and e-liquid type.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Produtos do Tabaco , Vaping , Adulto , Idoso , Estudos Transversais , Nível de Saúde , Humanos , Vaping/efeitos adversos
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