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1.
J Med Case Rep ; 15(1): 478, 2021 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-34579779

RESUMO

BACKGROUND: Graft-versus-host disease is a common complication seen with allogenic stem cell transplant, which is used to treat a variety of hematological malignancies. Graft-versus-host disease is an allogenic syndrome and can present in a variety of ways, including symptoms mimicking various autoimmune diseases; however, it is quite rare to see graft-versus-host disease affecting the vascular system and causing vasculitis. CASE PRESENTATION: We describe a case of a 59-year-old Caucasian man with follicular lymphoma and diffuse large B-cell transformation who developed graft-versus-host disease post allogenic hematopoietic stem cell transplantation and later progressed to neurological complication foot drop and large-vessel vasculitis. CONCLUSION: The life-threatening vascular complications associated with large-vessel vasculitis include arterial aneurysms and dissections, and ischemic or hemorrhagic stroke. Thus, this rare immunological association needs to be recognized and treated in a timely manner to prevent the long-term complications.


Assuntos
Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Vasculite , Doença Enxerto-Hospedeiro/complicações , Doença Enxerto-Hospedeiro/diagnóstico , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Transplante de Células-Tronco , Transplante Homólogo/efeitos adversos , Vasculite/etiologia
2.
BMC Infect Dis ; 21(1): 958, 2021 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-34530771

RESUMO

BACKGROUND: Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. CASE PRESENTATION: A 76-year old male with liver cirrhosis developed an immune complex vasculitis 12 days after the second injection of BNT162b2. On physical examination, the patient presented with pruritic purpuric macules on hands and feet, flexor and extensor parts of both legs and thighs and lower abdomen, and bloody diarrhoea. Laboratory testing showed elevated inflammatory markers. After short treatment with oral steroids all clinical manifestations and laboratory findings resolved. CONCLUSIONS: An increasing number of clinical manifestations have been attributed to COVID-19 infection and vaccination. This is the first written report of immune complex vasculitis after vaccination with BNT162b2. We present our case report and a discussion in the light of type three hypersensitivity reaction.


Assuntos
COVID-19 , Vasculite , Idoso , Complexo Antígeno-Anticorpo , Vacinas contra COVID-19 , Humanos , Masculino , SARS-CoV-2 , Vacinação/efeitos adversos , Vasculite/diagnóstico , Vasculite/etiologia
3.
Pediatr Pulmonol ; 56(10): 3422-3424, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34379888

RESUMO

BACKGROUND: Perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post-COVID-19 have been reported. Although SARS-CoV-2 has been shown to drive an exaggerated immune response in the pediatric population, such as in Multisystem Inflammatory Syndrome in Children (MIS-C), only one case of vasculitis following COVID-19 has been reported previously in children. CASE PRESENTATION: Seventeen-year-old male with a past medical history of COVID-19 pneumonia two months prior presented with acute kidney injury and diffuse alveolar hemorrhage. Rheumatologic workup revealed P-ANCA and Myeloperoxidase (MPO) positivity. Kidney biopsy showed necrotizing glomerulonephritis with limited immune complex deposition. Subsequently, he was treated with steroids and plasmapheresis, and ultimately started on cyclophosphamide. CONCLUSIONS: To our knowledge, this report presents the second reported pediatric case of P-ANCA/MPO vasculitis following COVID-19.


Assuntos
Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/imunologia , COVID-19/imunologia , SARS-CoV-2/imunologia , Síndrome de Resposta Inflamatória Sistêmica , Vasculite , Adolescente , Adulto , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/complicações , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/diagnóstico , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/tratamento farmacológico , Anticorpos Anticitoplasma de Neutrófilos , COVID-19/diagnóstico , COVID-19/virologia , Criança , Humanos , Masculino , Peroxidase , SARS-CoV-2/patogenicidade , Resultado do Tratamento , Vasculite/diagnóstico , Vasculite/etiologia
4.
Int J Lab Hematol ; 43 Suppl 1: 29-35, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34288441

RESUMO

Vascular endothelial injury is a hallmark of acute infection at both the microvascular and macrovascular levels. The hallmark of SARS-CoV-2 infection is the current COVID-19 clinical sequelae of the pathophysiologic responses of hypercoagulability and thromboinflammation associated with acute infection. The acute lung injury that initially occurs in COVID-19 results from vascular and endothelial damage from viral injury and pathophysiologic responses that produce the COVID-19-associated coagulopathy. Clinicians should continue to focus on the vascular endothelial injury that occurs and evaluate potential therapeutic interventions that may benefit those with new infections during the current pandemic as they may also be of benefit for future pathogens that generate similar thromboinflammatory responses. The current Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) studies are important projects that will further define our management strategies. At the time of writing this report, two mRNA vaccines are now being distributed and will hopefully have a major impact on slowing the global spread and subsequent thromboinflammatory injury we see clinically in critically ill patients.


Assuntos
COVID-19/complicações , Pandemias , SARS-CoV-2 , Trombofilia/etiologia , Vasculite/etiologia , Anticoagulantes/uso terapêutico , COVID-19/sangue , COVID-19/imunologia , Criança , Coagulação Intravascular Disseminada/etiologia , Endotélio Vascular/lesões , Endotélio Vascular/fisiopatologia , Feminino , Fibrinólise , Previsões , Humanos , Pulmão/irrigação sanguínea , Pulmão/patologia , Gravidez , Complicações Infecciosas na Gravidez/sangue , Tromboembolia/etiologia , Tromboembolia/prevenção & controle
5.
Int J Mol Sci ; 22(14)2021 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-34299162

RESUMO

IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.


Assuntos
Biomarcadores/análise , Epigênese Genética , Imunoglobulina A/metabolismo , Vasculite/terapia , Animais , Humanos , Vasculite/diagnóstico , Vasculite/etiologia , Vasculite/metabolismo
7.
Front Immunol ; 12: 640315, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34079539

RESUMO

Innate immune activity plays an essential role in the development of Kawasaki disease (KD) vasculitis. Extracellular release of high mobility group box-1 (HMGB-1), an endogenous damage-associated molecular pattern protein that can activate the innate immune system and drive host inflammatory responses, may contribute to the development of coronary artery abnormalities in KD. Prednisolone (PSL) added to intravenous immunoglobulin treatment for acute KD may reduce such abnormalities. Here, we evaluate the dynamics of HMGB-1 and therapeutic effects of PSL on HMGB-1-mediated inflammatory pathways on KD vasculitis in vitro. Serum samples were collected prior to initial treatment from patients with KD, systemic juvenile idiopathic arthritis (sJIA), and from healthy controls (VH), then incubated with human coronary artery endothelial cells (HCAECs). Following treatment of KD serum-activated HCAECs with PSL or PBS as a control, effects on the HMGB-1 signaling pathway were evaluated. Compared to that from VH and sJIA, KD serum activation induced HCAEC cytotoxicity and triggered extracellular release of HMGB-1. KD serum-activated HCAECs up-regulated extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK) and, p38 phosphorylation in the cytoplasm and nuclear factor kappa B (NF-κB) phosphorylation in the nucleus and increased interleukin (IL)-1ß and tumor necrosis factor (TNF)-α production. PSL treatment of KD serum-activated HCAECs inhibited extracellular release of HMGB-1, down-regulated ERK1/2, JNK, p38, and NF-κB signaling pathways, and decreased IL-1ß and TNF-α production. Our findings suggest that extracellular HMGB-1 plays an important role in mediating KD pathogenesis and that PSL treatment during the acute phase of KD may ameliorate HMGB-1-mediated inflammatory responses in KD vasculitis.


Assuntos
Anti-Inflamatórios/farmacologia , Proteína HMGB1/metabolismo , Síndrome de Linfonodos Mucocutâneos/metabolismo , Prednisolona/farmacologia , Células Cultivadas , Vasos Coronários , Células Endoteliais/efeitos dos fármacos , Células Endoteliais/metabolismo , Proteína HMGB1/efeitos dos fármacos , Humanos , Inflamação/metabolismo , Síndrome de Linfonodos Mucocutâneos/complicações , Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico , Vasculite/etiologia , Vasculite/metabolismo
8.
JCI Insight ; 6(13)2021 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-34061779

RESUMO

The emergence of the novel SARS coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has resulted in an unprecedented pandemic that has been accompanied by a global health crisis. Although the lungs are the main organs involved in COVID-19, systemic disease with a wide range of clinical manifestations also develops in patients infected with SARS-CoV-2. One of the major systems affected by this virus is the cardiovascular system. The presence of preexisting cardiovascular disease increases mortality in patients with COVID-19, and cardiovascular injuries, including myocarditis, cardiac rhythm abnormalities, endothelial cell injury, thrombotic events, and myocardial interstitial fibrosis, are observed in some patients with COVID-19. The underlying pathophysiology of COVID-19-associated cardiovascular complications is not fully understood, although direct viral infection of myocardium and cytokine storm have been suggested as possible mechanisms of myocarditis. In this Review, we summarize available data on SARS-CoV-2-related cardiac damage and discuss potential mechanisms of cardiovascular implications of this rapidly spreading virus.


Assuntos
COVID-19/complicações , Doenças Cardiovasculares/etiologia , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/etiologia , COVID-19/tratamento farmacológico , Doenças Cardiovasculares/diagnóstico , Fibrose/diagnóstico , Fibrose/etiologia , Humanos , Miocardite/diagnóstico , Miocardite/etiologia , Disautonomias Primárias/diagnóstico , Disautonomias Primárias/etiologia , Trombose/diagnóstico , Trombose/etiologia , Vasculite/diagnóstico , Vasculite/etiologia
9.
Med Clin North Am ; 105(4): 757-782, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34059249

RESUMO

Connective tissue diseases (CTDs) encompass a broad spectrum of clinical presentations that involve multidisciplinary management. Cutaneous findings are common in CTD and careful examination of these features aids in appropriate diagnosis and subsequent evaluation. Thorough work-up of CTD is crucial to properly identify disease subtypes and systemic involvement. Management plans can be developed based on diagnosis and systemic manifestations of disease. Disease management often requires treatment with pharmacotherapies with potential for toxicities, further underscoring the importance of diagnostic accuracy in this patient population. Evolving research strives to better elucidate the pathogenic mechanisms of CTDs allowing for more targeted treatment modalities.


Assuntos
Doenças do Tecido Conjuntivo/complicações , Doenças do Tecido Conjuntivo/tratamento farmacológico , Doenças do Tecido Conjuntivo/patologia , Tratamento Farmacológico/métodos , Adulto , Comorbidade , Doenças do Tecido Conjuntivo/diagnóstico , Dermatomiosite/diagnóstico , Dermatomiosite/etiologia , Dermatomiosite/patologia , Diagnóstico Diferencial , Tratamento Farmacológico/estatística & dados numéricos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Diagnóstico Precoce , Feminino , Humanos , Comunicação Interdisciplinar , Lúpus Eritematoso Cutâneo/diagnóstico , Lúpus Eritematoso Cutâneo/etiologia , Lúpus Eritematoso Cutâneo/patologia , Lúpus Eritematoso Discoide/diagnóstico , Lúpus Eritematoso Discoide/etiologia , Lúpus Eritematoso Discoide/patologia , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Sistêmico/etiologia , Lúpus Eritematoso Sistêmico/patologia , Masculino , Administração dos Cuidados ao Paciente/métodos , Escleroderma Sistêmico/diagnóstico , Escleroderma Sistêmico/etiologia , Escleroderma Sistêmico/patologia , Vasculite/diagnóstico , Vasculite/etiologia , Vasculite/patologia
10.
Viruses ; 13(6)2021 05 30.
Artigo em Inglês | MEDLINE | ID: mdl-34070832

RESUMO

Hepatitis B virus (HBV) chronic infection causes progressive liver damage, although about 20% of patients develop extrahepatic manifestations such as cryoglobulinemic vasculitis (CV). Clinical manifestations range from mild to moderate (purpura, asthenia, arthralgia) to severe (leg ulcers, peripheral neuropathy, glomerulonephritis, non-Hodgkin lymphoma). A comprehensive review of therapeutic options for HBV-related CV is lacking. Nucleos(t)ide analogues (NA) suppress HBV replication in 90-100% of cases and induce clinical response in most patients with mild-to-moderate CV. Plasma exchange can be performed in patients with severe CV and should be considered in severe or life-threatening cases combined with high doses of corticosteroids and antiviral treatment. A cautious use of rituximab can be considered only in association with NA treatment in refractory cases. A review of the literature and an analysis of data collected by six centers of the Italian Group for the Study of Cryoglobulinemia on 18 HBV-CV nucleotide/nucleoside analogues (NAs)-treated patients were carried out.


Assuntos
Crioglobulinemia/etiologia , Crioglobulinemia/terapia , Vírus da Hepatite B , Hepatite B/complicações , Vasculite/etiologia , Vasculite/terapia , Idoso , Terapia Combinada , Crioglobulinemia/diagnóstico , Gerenciamento Clínico , Suscetibilidade a Doenças , Feminino , Seguimentos , Hepatite B/virologia , Humanos , Itália , Masculino , Pessoa de Meia-Idade , Nucleosídeos/análogos & derivados , Nucleosídeos/uso terapêutico , Fenótipo , Resultado do Tratamento , Vasculite/diagnóstico
11.
World J Gastroenterol ; 27(18): 2073-2089, 2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34025065

RESUMO

Infection with hepatotropic viruses is not limited to the liver and can lead to the development of various immunological disorders (the formation of cryoglobulins, rheumatoid factor, antinuclear antibodies, autoantibodies specific for autoimmune hepatitis and primary biliary cholangitis, and others), which can manifest as glomerulonephritis, arthritis, uveitis, vasculitis (cryoglobulinemic vasculitis, polyarteritis nodosa, Henoch-Schonlein purpura, isolated cutaneous necrotizing vasculitis), and other rheumatologic disorders, and be a trigger for the subsequent development of autoimmune hepatitis and primary biliary cholangitis. A further study of the association between autoimmune liver diseases and hepatotropic virus infection would be useful to assess the results of treatment of these associated diseases with antiviral drugs. The relationship of these immune disorders and their manifestations with hepatotropic viruses is best studied for chronic hepatitis B and C. Only isolated cases of these associations are described for hepatitis A. These links are least studied, and are often controversial for hepatitis E, possibly due to their relatively rare diagnoses. Patients with uveitis, glomerulonephritis, arthritis, vasculitis, autoimmune liver diseases should be tested for biomarkers of viral hepatitis, and if present, these patients should be treated with antiviral drugs.


Assuntos
Artrite Reumatoide , Crioglobulinemia , Hepatite B Crônica , Doenças do Sistema Imunitário , Vasculite , Crioglobulinemia/diagnóstico , Humanos , Vasculite/diagnóstico , Vasculite/etiologia
12.
Ann R Coll Surg Engl ; 103(5): e148-e150, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33851888

RESUMO

Adverse reactions to metal debris in relation to metal-on-metal hip arthroplasty has been heavily discussed in the literature. In contrast, few cases have been reported in the context of total knee arthroplasty. A 77-year-old woman presented with a painful total knee arthroplasty. At the time of revision surgery, intra-articular cream-coloured fluid and material was found in association with a well-fixed prosthesis. Synovial and capsular samples were obtained for histological assessment and a diagnosis of aseptic lymphocytic vasculitis associated lesion was confirmed. The patient went on to have an uncomplicated recovery following a two-stage revision to a constrained knee prosthesis.


Assuntos
Artroplastia do Joelho/efeitos adversos , Prótese de Quadril/efeitos adversos , Próteses Articulares Metal-Metal/efeitos adversos , Vasculite , Idoso , Feminino , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/cirurgia , Humanos , Linfócitos/citologia , Reoperação , Líquido Sinovial/citologia , Vasculite/diagnóstico , Vasculite/etiologia , Vasculite/patologia
13.
Int J Mol Sci ; 22(8)2021 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-33917744

RESUMO

Coronary artery disease (CAD) and its complications are the leading cause of death worldwide. Inflammatory activation and dysfunction of the endothelium are key events in the development and pathophysiology of atherosclerosis and are associated with an elevated risk of cardiovascular events. There is great interest to further understand the pathophysiologic mechanisms underlying endothelial dysfunction and atherosclerosis progression, and to identify novel biomarkers and therapeutic strategies to prevent endothelial dysfunction, atherosclerosis and to reduce the risk of developing CAD and its complications. The use of liquid biopsies and new molecular biology techniques have allowed the identification of a growing list of molecular and cellular markers of endothelial dysfunction, which have provided insight on the molecular basis of atherosclerosis and are potential biomarkers and therapeutic targets for the prevention and or treatment of atherosclerosis and CAD. This review describes recent information on normal vascular endothelium function, as well as traditional and novel potential biomarkers of endothelial dysfunction and inflammation, and pharmacological and non-pharmacological therapeutic strategies aimed to protect the endothelium or reverse endothelial damage, as a preventive treatment for CAD and related complications.


Assuntos
Biomarcadores , Doença da Artéria Coronariana/etiologia , Doença da Artéria Coronariana/metabolismo , Endotélio Vascular/metabolismo , Endotélio Vascular/fisiopatologia , Vasculite/etiologia , Vasculite/metabolismo , Animais , Permeabilidade Capilar , Doença da Artéria Coronariana/tratamento farmacológico , Doença da Artéria Coronariana/fisiopatologia , Gerenciamento Clínico , Suscetibilidade a Doenças , Hemostasia , Humanos , Terapia de Alvo Molecular/métodos , Vasculite/tratamento farmacológico , Vasculite/fisiopatologia
14.
Curr Opin Neurol ; 34(3): 417-422, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-33852526

RESUMO

PURPOSE OF REVIEW: Over the course of the coronavirus disease (COVID-19) pandemic, it has become increasingly clear that there is a high prevalence of neurological complications in people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RECENT FINDINGS: Studies of central nervous system (CNS) tissue in brain model systems and from adults with acute SARS-CoV-2 infection have begun to uncover potential mechanisms for neurological damage during COVID-19. These studies suggest that direct viral invasion of the CNS occurs in a subset of cases but does not frequently cause overt viral meningoencephalitis. Vascular abnormalities including microvascular thrombi and endothelial activation, as well as parainfectious processes, including CNS specific immune responses, may contribute to neurological symptoms during acute SARS-CoV-2 infection. SUMMARY: Neuroimmune perturbations and vascular inflammation observed in people with COVID-19 may warrant investigation of immune-modulating interventions to ameliorate neurological complications associated with acute SARS-CoV-2 infection. These therapies may also impact the trajectory of potential long-term complications of COVID-19.


Assuntos
COVID-19/complicações , Doenças do Sistema Nervoso/etiologia , Doenças do Sistema Nervoso/patologia , Humanos , Imunoterapia , Doenças do Sistema Nervoso/imunologia , Doenças do Sistema Nervoso/terapia , Vasculite/etiologia , Vasculite/imunologia
15.
BMJ Case Rep ; 14(4)2021 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-33846189

RESUMO

We describe a case of a 48-year-old woman who presented with acute respiratory failure due to diffuse alveolar haemorrhage and acute renal failure due to pauci-immune glomerulonephritis consistent with a new diagnosis of microscopic polyangiitis (MPA). The patient had a recent SARS-CoV-2 infection 6 weeks before MPA diagnosis and had stopped immunosuppression for her rheumatoid arthritis (RA) at that time. The patient was treated with pulse intravenous steroids, plasma exchange therapy and rituximab, which induced remission of her illness. This case highlights a timely dilemma of holding immunosuppression in a RA patient with low disease activity on combination therapy with SARS-CoV-2 infection, and the potential risk of developing an additional autoimmune disease, such as vasculitis, given their existing autoimmunity due to RA.


Assuntos
Artrite Reumatoide/tratamento farmacológico , COVID-19/complicações , Imunossupressores/administração & dosagem , Vasculite/etiologia , Suspensão de Tratamento , Injúria Renal Aguda , Artrite Reumatoide/complicações , Diagnóstico Diferencial , Feminino , Glomerulonefrite , Hemorragia , Humanos , Pneumopatias , Poliangiite Microscópica , Pessoa de Meia-Idade , Troca Plasmática , Indução de Remissão , Síndrome do Desconforto Respiratório , Rituximab/uso terapêutico
16.
Rinsho Shinkeigaku ; 61(4): 239-242, 2021 Apr 21.
Artigo em Japonês | MEDLINE | ID: mdl-33762495

RESUMO

A 78-year-old woman was diagnosed with herpes zoster in the first branch of the trigeminal nerve and was treated with amenamevir. Subsequently, she was hospitalized for postherpetic neuralgia. Fever and unconsciousness were observed, and a diagnosis of varicella-zoster virus meningoencephalitis and vasculitis was made. In addition to the antithrombotic therapy, she was treated with intravenous acyclovir and steroid pulse therapy; however, her unconsciousness persisted. Amenamevir was not transferrable to the spinal fluid and resulted in an incomplete treatment of herpes zoster in the cerebral nerve region, suggesting that this case may be related to the severe course of the disease.


Assuntos
Aciclovir/administração & dosagem , Antivirais/uso terapêutico , Herpes Zoster/complicações , Herpes Zoster/tratamento farmacológico , Meningoencefalite/tratamento farmacológico , Meningoencefalite/etiologia , Oxidiazóis/uso terapêutico , Nervo Trigêmeo , Vasculite/tratamento farmacológico , Vasculite/etiologia , Idoso , Antivirais/administração & dosagem , Antivirais/efeitos adversos , Antivirais/líquido cefalorraquidiano , Feminino , Humanos , Infusões Intravenosas , Imageamento por Ressonância Magnética , Meningoencefalite/diagnóstico , Meningoencefalite/virologia , Metilprednisolona/administração & dosagem , Oxidiazóis/efeitos adversos , Oxidiazóis/líquido cefalorraquidiano , Pulsoterapia , Índice de Gravidade de Doença , Vasculite/diagnóstico , Vasculite/virologia
18.
Lupus ; 30(4): 541-548, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33583236

RESUMO

Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced against a variety of phospholipids and phospholipid-binding proteins. The purpose of this article is to review cutaneous findings in patients with APS diagnosis. An overview regarding prevalence, description, pathogenesis and histopathology, are described for cutaneous manifestations of APS.


Assuntos
Anticorpos Antifosfolipídeos/imunologia , Síndrome Antifosfolipídica/patologia , Livedo Reticular/patologia , Dermatopatias/patologia , Vasculite/patologia , Adulto , Idoso , Anetodermia/etiologia , Anetodermia/patologia , Anticorpos Anticardiolipina/imunologia , Síndrome Antifosfolipídica/diagnóstico , Síndrome Antifosfolipídica/epidemiologia , Síndrome Antifosfolipídica/imunologia , Biópsia , Feminino , Gangrena/etiologia , Gangrena/patologia , Humanos , Livedo Reticular/diagnóstico , Livedo Reticular/etiologia , Livedo Reticular/imunologia , Inibidor de Coagulação do Lúpus/imunologia , Masculino , Papulose Atrófica Maligna/etiologia , Papulose Atrófica Maligna/patologia , Pessoa de Meia-Idade , Necrose/diagnóstico , Necrose/etiologia , Prevalência , Dermatopatias/imunologia , Úlcera/patologia , Vasculite/etiologia
19.
Int J Immunogenet ; 48(2): 110-119, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33586864

RESUMO

Antibody-mediated rejection (ABMR) stands as the major limitation to long-term transplant outcome. The immunologic understanding of ABMR continues to progress and has identified natural killer (NK) cells as key effector cells promoting and coordinating the immune attack on the graft microvascular endothelium. This review discusses the current concepts outlining the different ways that allow for NK cell recognition of graft endothelial cells which includes antibody-dependent as well as independent processes.


Assuntos
Endotélio Vascular/patologia , Rejeição de Enxerto/imunologia , Isoanticorpos/imunologia , Células Matadoras Naturais/imunologia , Especificidade de Anticorpos , Citotoxicidade Imunológica , Endotélio Vascular/imunologia , Rejeição de Enxerto/patologia , Humanos , Imunoglobulina G/imunologia , Linfócitos/imunologia , Monócitos/imunologia , Receptores de IgG/imunologia , Transplantes/irrigação sanguínea , Transplantes/imunologia , Vasculite/etiologia , Vasculite/imunologia
20.
Br J Haematol ; 193(1): 43-51, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33538335
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