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2.
Bol. méd. postgrado ; 36(2): 7-20, dic.2020. tab, ilus
Artigo em Espanhol | LILACS, LIVECS | ID: biblio-1117892

RESUMO

El presente estudio fue realizado para desarrollar una reflexión crítica acerca de la formación médica en la Venezuela del siglo XXI, interpretando realidades y consecuencias desde las voces de médicos expertos y jóvenes graduados formados en la Universidad Centroccidental Lisandro Alvarado (UCLA). Es un estudio desde el paradigma cualitativo en la modalidad crítica interpretativa, la ruta metodológica fue la hermenéutica crítica y el análisis crítico del discurso. Se utilizó el muestreo intencional y la entrevista para recopilar la narrativa de los actores sociales, categorizándola e interpretándola contrastando voces de actores, teóricos y el autor como instrumento heurístico. Los resultados indican que la formación médica socializa el paradigma biomédico cuantitativo como opción única y válida en la producción de conocimiento y en el mundo académico, con un enfoque evolucionista, organicista, positivista y racional que fragmenta al ser humano. Esta formación académica se cumple en un sistema educativo dual: las universidades autónomas y la universidad bolivariana revolucionaria, con profundas diferencias entre ellas que generan perfiles de egresados contradictorios. La formación del futuro médico implica desarrollar el saber, el saber hacer, saber ser profesional y saber convivir. En conclusión, la formación médica debe cumplirse en centros universitarios calificados y certificados; sus egresados deben ser de alto perfil científico, tecnológico y humanístico los cuales deben dar respuestas pertinentes y oportunas a los problemas de salud de la población venezolana(AU)


This study was conducted to develop a reflective critic about medical training in Venezuela in the 21st century interpreting thoughts from the voices of expert doctors and young graduates from the Universidad Centroccidental Lisandro Alvarado (UCLA). This is a qualitative sociocritical study using critical hermeneutics and critical analysis of speech. Intentional sampling and interviewing was used to collect the narrative of the medical professionals. The results shows that medical training socializes the quantitative biomedical paradigm as the only valid option in the production of knowledge and in the academic world, with an evolutionist, organicist, rational and positivist approach, which divides the human being in parts. In Venezuela, a dual educational system exists: autonomous universities and the Bolivarian University with deep differences between them, which generate conflicting graduate profiles. Training of the future doctors implies developing medical knowledge, the know-how, learning how to be a professional and coexist with others. In conclusion, medical training must be performed in qualified and certified university centers; their graduates should have high scientific, technological and humanistic profiles which will allow them to provide pertinent and timely answers to the health problems of the Venezuelan population(AU)


Assuntos
Faculdades de Medicina , Estudantes de Medicina , Medicina Geral , Venezuela , Programas de Estudo , História da Medicina
3.
Zootaxa ; 4768(4): zootaxa.4768.4.8, 2020 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-33055641

RESUMO

Phylloicus is the most species-rich genus of the Neotropical Calamoceratidae. In Venezuela, twelve species are known from the adult stage and, from those, only one has its larval and pupal stages described. Here, we describe and illustrate the larva, pupa, and case of Phylloicus cressae, from a first order stream of the heavily disturbed Tuy River watershed in the peri-urban area of Caracas, northcentral Venezuela.


Assuntos
Florestas , Insetos , Animais , Larva , Pupa , Venezuela
5.
Recurso na Internet em Espanhol | LIS - Localizador de Informação em Saúde | ID: lis-47882

RESUMO

Espacio de la Web institucional del Ente Rector en Salud de Venezuela, donde se publican normativas, reportes, medidas y protocolos para el abordaje del Covid-19 en el país


Assuntos
Infecções por Coronavirus/prevenção & controle , Pandemias/prevenção & controle , Venezuela
6.
Recurso na Internet em Espanhol | LIS - Localizador de Informação em Saúde | ID: lis-47828

RESUMO

Portal Gubernamental que ofrece información sobre capacidades del talento humano, infraestructura científica y producción científica, Indicadores en Ciencia, Tecnología e Innovación, Proyectos de Investigación, Vigilancia Tecnológica, Libros y Boletines editados por el Fondo Editorial del MPPCTI de la República Bolivariana de Venezuela


Assuntos
Observatórios de Ciência e Tecnologia , Venezuela
7.
Rev Assoc Med Bras (1992) ; 66(8): 1139-1145, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32935811

RESUMO

OBJECTIVE: To analyze the scientific evidence on the disclosure of the diagnostic of adolescents infected by HIV/AIDS in the South American context. DATABASE: Systematic literature review using the PubMed, Cinahal, Embase, Cochrane, BVS, and Global Health databases and the descriptors: adolescent and HIV and family and Argentina or Bolivia or Brasil or Chile or Colombia or Ecuador or French Guiana or Paraguay or Peru or Uruguay or Venezuela. DATA SYNTHESIS: Brasil was the country highlighted. It was verified that parents have a direct and indirect influence over the adolescents' life, especially regarding behaviors and health care. Dialog among family members can reduce adolescents' vulnerability to HIV and encourage diagnostic disclosure. CONCLUSION: It is necessary to amplify research involving adolescents with HIV/AIDS and their parents/caregivers and family members to improve care and reduce the cases of the disease. It is suggested that policies of prevention and treatment should involve families, caregivers, partners, and the community.


Assuntos
Revelação , Infecções por HIV , Adolescente , Argentina , Brasil , Chile , HIV , Humanos , Peru , Venezuela
8.
Clin Dermatol ; 38(4): 497-501, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32972610

RESUMO

José Maria Vargas, (1786-1854), who was born on March 10, 1796, graduated with a Doctor of Medicine degree from the Central University of Venezuela in 1808. He was subsequently imprisoned in 1813 by the Spanish authorities for his independence activities. When finally freed, he traveled to Edinburgh for postgraduate medical training and became the first Venezuelan to earn a Fellowship of the Royal Colleges of Surgeons of Edinburgh. He worked afterward in medicine, surgery, botany, and chemistry, practicing in Scotland, France, and Puerto Rico. Upon his return to Venezuela in 1825 from 1827 to 1829, he became Professor of Surgery and later, President (Rector) of the Central University of Venezuela. He was elected the second president of newly independent Venezuela serving from 1835 to 1836 and carried out his tasks with honor and dignity, even after surviving a coup d'état. Finally, he resigned his position as president and returned to the practice of medicine and his teaching duties. He reasoned and wrote a beautiful differential diagnosis in a case supposedly of pellagra, but actually of erythema marginatum. Dr Vargas died in New York on July 13, 1854, after a long illness.


Assuntos
Dermatologia/história , Cirurgia Geral/história , Diagnóstico Diferencial , Eritema , Europa (Continente) , Feminino , França , História do Século XVIII , História do Século XIX , Humanos , Masculino , New York , Pelagra , Porto Rico , Escócia , Venezuela
9.
Caracas; Observatorio Nacional de Ciencia, Tecnología e Innovación; ago. 2020. 144-167 p. (Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 5, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1118165

RESUMO

Instalada la pandemia de la Covid-19 la gran expectativa colectiva gira en torno al retorno a la normalidad. En este ensayo se pone en entredicho el concepto de 'normalidad' en el contexto de los factores determinantes de la emergencia de los virus con altas tasas de morbilidad y mortalidad, evidenciando que el estado de 'normalidad pre-pandemia', al cual se aspira retornar, presenta indicadores socio-ambientales mucho más preocupantes y trágicos que aquellos que la mediática global nos suministra, de manera permanente y en tiempo real, sobre la Covid-19. Se presentan evidencias para argumentar que el principio sine qua non del crecimiento económico como motor determinante e insustituible del desarrollo, y más aún del modelo capitalista de desarrollo, es metabólicamente insostenible al demandar cantidades permanentemente incrementales de energía y bienes de la naturaleza en un planeta incapaz de sostener semejante pretensión. Las pandemias no son las únicas consecuencias fatales de la destrucción de la naturaleza y tampoco las más graves. Son síntomas de un modelo en crisis, que el desarrollo sustentable pretende aliviar sin avocarse al tratamiento de la patología que los origina. Por este motivo, se sostiene que es necesario construir una 'nueva normalidad', diferente a la 'normalidad pre-pandemia' por ser esta inviable, lo que implica evaluar los fundamentos del modelo. Se convoca a una impostergable reflexión, diversa e inclusiva, desde el seno de la comunidad científica, con el desprendimiento suficiente para admitir otras visiones y conocimientos que tienen mucho que aportar desde otras formas de coexistir con la naturaleza(AU)


Once Covid-19 pandemic established among us, the great collective expectation is about the return to normal pre-pandemic conditions. This assay questions the concept of 'normality' related to the context where high morbidity-mortality virus emerge out, showing that pre-pandemic normal conditions, have worst and overwhelming socio-environmental indicators than Covid-19 reports, daily supplied by global mass media in real time. We offer evidences that suggest that the sine qua non principle of economic growth, as indisputable driver of development, and even more, of the capitalist model, is metabolically unsustainable, due to the astonishing demands of energy and goods from nature, beyond its own capacity. Pandemics are not the only fatal consequences of ecological destruction, and by no means among the worst. They are just a symptom of the crisis of the development model, which the sustainable development pretends to relieve, ignoring the pathology that originated it. Due to this fact, we sustain that a new normal conditions is required to be created, truly different to pre-pandemic conditions, and that demands assessing the model's principles. We invite the scientific society for an urgent, inclusive and diverse reflection, willing to recognize other perspectives and knowledge, that could offer alternatives ways to coexist with nature(AU)


Assuntos
Desenvolvimento Econômico , Infecções por Coronavirus , Pandemias , Desenvolvimento Sustentável , Crescimento , Venezuela , Capitalismo , Determinantes Sociais da Saúde
10.
Caracas; Observatorio Nacional de Ciencia, Tecnología e Innovación; ago.2020. 124-143 p. ilus.(Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 5, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1118169

RESUMO

La nueva pandemia de Covid-19 nos obliga a un debate de naturaleza compleja, multi-dimensional y con factores en permanentes incertidumbres, que conduce a auto-reflexiones y redimensiones de nuestro papel, acciones y corresponsabilidades para con la sociedad y el futuro. Este ensayo aspira elevar, revalorar y configurar las reflexiones relevantes para el debate y las soluciones; considera tanto las condiciones históricas en las elaboraciones teóricas, como las razones paradigmáticas que nos ayudan a aproximarnos a los problemas y sus respuestas; reconoce el encuentro de los paradigmas de salud que el gobierno bolivariano impulsa y las estrategias, dinámicas, investigaciones, gestiones y logros al combatir y frenar la pandemia del Covid-19, que refuerza con lo que aquí denominamos "Paradigma de Salud y Ambiente para la Vida". Mediante estrategias descriptivo-reflexivas, y con gran alcance hacia el despliegue de la conceptualización y aplicación de los diez factores básicos integradores del paradigma referido, avanza en las ideas, propuestas y sueños necesarios para la consolidación de un Sistema Nacional de Salud Universal para Venezuela, al tiempo que apuntilla los requerimientos necesarios para el tránsito y la consolidación del mismo, y apuesta a propuestas concretas para el desarrollo del paradigma en sí(AU)


The new Covid-19 pandemic forces us to a debate of a complex, multi-dimensional nature and with factors in permanent uncertainties, which lead to self-reflections and re-dimensions of our role, actions and co-responsibilities towards society and the future. This essay aims to raise, re-evaluate and configure the reflections relevant to the debate and solutions; it considers both the historical conditions in the theoretical elaborations and the paradigmatic reasons that help us to approach the problems and their answers; recognizes the meeting of the health paradigms that the Bolivarian government promotes and the strategies, dynamics, investigations, efforts and achievements, in lighting and stopping the Covid-19 pandemic, which reinforces with what we call the "Paradigm of Health and Environment for Life". Through descriptive-reflective strategies, and with great scope towards the deployment of the conceptualization and application of the ten basic factors integrating the referred paradigm, it advances in the ideas, proposals and dreams necessary for the consolidation of a National Universal Health System for Venezuela, at the same time that it outlines the necessary requirements for its growth and consolidation, and sets out concrete proposals for the development of the paradigm itself(AU)


Assuntos
Humanos , Ciência , Venezuela , Saúde Ambiental , Saúde , Infecções por Coronavirus , Meio Ambiente , Sistemas Nacionais de Saúde , Pandemias , Cobertura Universal de Saúde
11.
Caracas; Observatorio Nacional de Ciencia, Tecnología e Innovación; ago. 2020. 91-110 p. ilus, tab.(Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 5, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1118176

RESUMO

La novedosa pandemia por coronavirus, etiquetada por la Organización Mundial de la Salud OMS, 2020) como la covid-19, se reportó por primera vez en Wuhan, China, el 31 de diciembre de 2019 y a la fecha, según estimaciones de la misma OMS (2020), en la medida en que se ha extendido a nivel planetario, ha infectado a más de 9,2 millones de personas, de las cuales se reportan más de 500.000 fallecidos y 5.2 millones de pacientes recuperados. En este estudio, aplicaremos el exponente de Hurst (1951) asociado con la estadística fractal para simular la propagación de la covid-19, considerando series temporales de fluctuaciones de nuevos casos diarios de la enfermedad, disponibles a través de un sitio web de referencia de la República Bolivariana de Venezuela, como lo es el Observatorio Nacional de Ciencia, Tecnología e Innovación (ONCTI). Se parte de la hipótesis de que la propagación de la covid-19, puede analizarse en función de las fluctuaciones del crecimiento de nuevos casos diarios de contagio. Para ello, se empleó un método de rango reescalado R/S que permitió calcular el Exponente de Hurst, parámetro estocástico cuyo valor permitió inferir sobre la presencia de correlaciones de largo alcance en la transmisión del virus entre la población. Estudiaremos los efectos de correlación en la propagación de COVID-19 en Venezuela mediante el análisis de las series temporales de nuevos casos después del decreto de Alerta dictado por el Ejecutivo Nacional que convocó a la ciudadanía a "quedarse en casa" mediante una cuarentena social obligatoria. Simularemos el comportamiento a mediano plazo (180 días) considerando las fluctuaciones de los nuevos casos de contagio diarios sobre la base de dos factores: los casos de contagio importados y los contagios comunitarios. En consecuencia, inicialmente examinaremos el origen de correlaciones con grandes fluctuaciones, y posteriormente analizaremos en base a las series de tiempo de nuevos casos diarios de la covid-19 en Venezuela, para luego establecer las correlaciones de largo alcance e inferir sobre la posible la persistencia o antipersistencia de la misma(AU)


The novel coronavirus pandemic, labeled by the World Health Organization (WHO) as Covid-19, was first reported in Wuhan, China, on December 31, 2019. To date, according to the WHO's estimates, it has infected more than 9.2 million people, of whom more than 500,000 are reported dead, and 5.2 million patients have recovered. To deepen in its study, we apply the Hurst exponent, associated with fractal statistics to simulate the spread of Covid-19, considering time series of fluctuations of new daily cases, which are available in a site reference website of the Bolivarian Republic of Venezuela, such as the National Observatory for Science, Technology, and Innovation (ONCTI). This work starts from the hypothesis that the spread of Covid-19 can be analyzed based on the fluctuations in the increase of new daily cases. For this, an R / S rescaled range method was used that allowed calculating the Hurst Exponent, a stochastic parameter whose value allowed inferring the presence of long-range correlations in the virus transmission among the population. We will study the correlation effects in the spread of COVID-19 in Venezuela by analyzing the time series of new cases after the alert decree issued by the Executive branch, which called on citizens to "stay at home" through a mandatory social quarantine. Consequently, initially, we will examine the origin of correlations with large fluctuations, followed by an analysis based on the time series of new daily cases of Covid-19 in Venezuela, in order to establish the long-range correlations and infer about the possible persistence or anti persistence of it(AU)


Assuntos
Humanos , Venezuela , Quarentena , Infecções por Coronavirus , Pandemias , Estudos de Séries Temporais , Fractais
12.
Distrito Capital; Observatorio Nacional de Ciencia, Tecnología e Innovación; ago. 2020. 8-13 p. (Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 2, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1117766
13.
Caracas; Observatorio Nacional de Ciencia, Tecnología e Innovación; ago. 2020. 32-52 p. ilus, tab.(Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 5, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1118413

RESUMO

Se describe el comportamiento de la COVID-19 en la República Bolivariana de Venezuela durante el período febrero-junio 2020, mediante la caracterización epidemiológica según tiempo, espacio, persona y tipo de transmisión de los casos confirmados y fallecidos por esta enfermedad. Se identifican condiciones relacionadas con la mortalidad. Es un estudio descriptivo, observacional, retrospectivo que utilizó la base de datos de COVID-19 del Sistema Único de Información en Salud (SUIS) del Ministerio del Poder Popular para la Salud (MPPS). Se evidencia que después de la confirmación de los primeros casos, la incidencia se mantuvo estable hasta mediados de mayo, cuando la curva de casos confirmados presentó una inflexión abrupta, lo que se relacionó en gran medida con casos importados. La enfermedad ha afectado en su mayoría a personas del sexo masculino, menores de 40 años, con un elevado porcentaje de forma clínica asintomáticas. La letalidad registrada en el período es menos de 1% y está relacionada a la edad avanzada, presencia de comorbilidades como hipertensión arterial y/o diabetes. Se concluye que la COVID-19 ha afectado mayormente a personas menores de 40 años, con casos relacionados en su mayoría con el regreso de connacionales provenientes de países vecinos, con una proporción importante de casos asintomáticos, lo cual a su vez se encuentra asociado a la baja tasa de complicaciones y de mortalidad por esta enfermedad en Venezuela(AU)


The behavior of COVID-19 in the Bolivarian Republic of Venezuela during the period February - June 2020, is described through the epidemiological characterization according to time, space, person and type of transmission of the confirmed and deceased cases of this disease. Conditions related to mortality are identified. A descriptive, observational, retrospective study used the COVID-19 database of the Unified Health Information System (SUIS) of the Ministerio del Poder Popular para la Salud (MPPS). It is evident that after the confirmation of the first cases, the incidence remained stable until mid-May, when the curve of confirmed cases presented an abrupt inflection, which was largely related to imported cases. The disease has affected mostly male people, under 40, with a high percentage of clinically asymptomatic. The case fatality rate recorded in the period is less than 1% and is related to old age, the presence of comorbidities such as high blood pressure and / or diabetes. It is concluded that COVID-19 has mainly affected people under 40, with cases mostly related to the return of compatriots from neighboring countries, with a significant proportion of asymptomatic cases, which in turn are associated with the low rate of complications and mortality from this disease in Venezuela(AU).


Assuntos
Humanos , Venezuela , Incidência , Mortalidade , Infecções por Coronavirus/epidemiologia , Comorbidade
14.
s.l; Fundación Programa de Investigación y Estudios Estratégicos;Latinoamericanos (Pinves); ago 2020. 211 p. graf.
Não convencional em Espanhol | LILACS, LIVECS | ID: biblio-1117643

RESUMO

El conjunto de ensayos que componen este libro han sido hechos en plena pandemia y procuran aportar a la memoria histórica latinoamericana y caribeña, además de ser un documento elaborado únicamente por mujeres, cuya sensibilidad y capacidad intelectual se unen con el fin de alertar a las lectoras y los lectores acerca de la peligrosidad del asedio contra la Revolución bolivariana, que pone en riesgo, sin duda alguna, la paz de toda la humanidad(AU)


Assuntos
Humanos , Venezuela , Infecções por Coronavirus , Pandemias , Memória
15.
Educ. med. (Ed. impr.) ; 21(4): 272-276, jul.-ago. 2020.
Artigo em Espanhol | IBECS | ID: ibc-192658

RESUMO

La Organización Mundial de la Salud, en fecha 11 de marzo del 2020, declara la situación de pandemia debida a la aparición de un nuevo coronavirus, síndrome respiratorio agudo severo-coronavirus 2 (SARS-CoV-2), que produce la enfermedad infecciosa por coronavirus denominada COVID-19. En Venezuela, la educación universitaria y, particularmente la educación médica por su relación estrecha con la Pandemia, se han visto severamente afectadas. En este artículo se revisa la evidencia disponible y las opiniones con respecto a la educación médica en tiempos de COVID-19. Planteamos una serie de retos que debe afrontar la universidad desde la reflexión y el planteamiento de soluciones en un contexto de incertidumbre y cambios acelerados para el futuro de la educación médica. El panorama para la educación médica en el país y a nivel global es incierto, adverso por ahora, pero el proceso evolutivo no solo ofrece ambientes adversos, sino también la posibilidad de generar procesos adaptativos, con la búsqueda y la implementación de nuevas formas de hacer la docencia, y esto último puede involucrar un giro positivo y necesario para la formación de los nuevos profesionales de la salud


On 11 March 2020 the World Health Organisation declared the Pandemic situation due to a new coronavirus, Severe Acute Respiratory Syndrome -Coronavirus 2 (SARS-CoV-2), which caused the infectious disease due to coronavirus called COVID-19. University education in Venezuela, and particularly medical education, due to its close relationship with the Pandemic, has been severely affected. A review is presented in this article on the available evidence and opinions as regards medical education in the COVID-19 era. A series of challenges are set out which the University may face from the reflection and the establishing of solutions in a context of uncertainty and accelerated changes for the future of Medical Education. The outlook for Medical Education in the country and at world level is uncertain, and although unfavourable at the moment, the evolutionary process not only offers adverse environments, but also the possibility of generating adaptive processes, and the search and implementation of new ways of teaching. This latter, may involve a positive and necessary change for the teaching of new health professionals


Assuntos
Humanos , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Educação Médica , Venezuela , Currículo , Avaliação Educacional , Responsabilidade Social
16.
Mem Inst Oswaldo Cruz ; 115: e200043, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32667459

RESUMO

BACKGROUND The number of malaria cases in Roraima nearly tripled from 2016 to 2018. The capital, Boa Vista, considered a low-risk area for malaria transmission, reported an increasing number of autochthonous and imported cases. OBJECTIVES This study describes a spatial analysis on malaria cases in an urban region of Boa Vista, which sought to identify the autochthonous and imported cases and associated them with Anopheles habitats and the potential risk of local transmission. METHODS In a cross-sectional study at the Polyclinic Cosme e Silva, 520 individuals were interviewed and diagnosed with malaria by microscopic examination. Using a global positional system, the locations of malaria cases by type and origin and the breeding sites of anopheline vectors were mapped and the risk of malaria transmission was evaluated by spatial point pattern analysis. FINDINGS Malaria was detected in 57.5% of the individuals and there was a disproportionate number of imported cases (90.6%) linked to Brazilian coming from gold mining sites in Venezuela and Guyana. MAIN CONCLUSIONS The increase in imported malaria cases circulating in the west region of Boa Vista, where there are positive breeding sites for the main vectors, may represent a potential condition for increased autochthonous malaria transmission in this space.


Assuntos
Anopheles/parasitologia , Malária/diagnóstico , Malária/transmissão , Mineradores/estatística & dados numéricos , Mosquitos Vetores/parasitologia , Plasmodium/isolamento & purificação , Viagem , Adulto , Animais , Anopheles/classificação , Brasil/epidemiologia , Estudos Transversais , Feminino , Sistemas de Informação Geográfica , Ouro , Guiana , Humanos , Malária/epidemiologia , Malária/parasitologia , Masculino , Pessoa de Meia-Idade , Plasmodium/classificação , Análise Espacial , População Urbana , Venezuela
18.
Caracas; Observatorio Nacional de Ciencia, Tecnología e Innovación; 9 jul. 2020. 15-31 p. (Observador del Conocimiento. Revista Especializada en Gestión Social del Conocimiento, 5, 2).
Monografia em Espanhol | LILACS, LIVECS | ID: biblio-1119053

RESUMO

En diciembre 2019, en Wuhan, China, se registró un aumento inusual de casos de infección respiratoria aguda de rápida progresión y alta letalidad. Al poco tiempo es identificado el agente causal, un coronavirus denominado SARS-CoV-2 y se caracteriza una nueva enfermedad, COVID-19. En ausencia hasta el momento de tratamientos específicos, eficaces y seguros, se justifica explorar alternativas científicamente fundamentadas a nuestro alcance como el uso de Plasma de Convaleciente (PC-CoV19) como coadyuvante para el tratamiento de la COVID-19. El plasma de pacientes recuperados de una enfermedad infecciosa, Plasma de Convaleciente, ha sido utilizado en el tratamiento de patologías infecciosas. Hay antecedentes inmediatos de su uso en enfermedades producidas por otro tipo de coronavirus y se registran experiencias y estudios clínicos con resultados preliminares durante esta pandemia. Quimbiotec, empresa productora de hemoderivados y fármacos recombinantes del Estado venezolano, y el Banco Municipal de Sangre, definen un protocolo para promover condiciones para la aféresis, procesamiento, conservación, almacenamiento, distribución, transfusión y evaluación de la seguridad y eficacia del PC-CoV19 como alternativa en el tratamiento de la COVID-19 en Venezuela. Se incluye la identificación de capacidades y de talento, la estructura física, equipos y especialistas necesarios, así como la definición de procesos para establecer rutinas controladas y auditables para sentar bases del acceso y uso del PC-CoV19 en el Sistema Nacional de Salud de Venezuela y preparar el diseño y ejecución de estudios clínicos. Se presenta el Protocolo y algunos nudos críticos en su ejecución a la fecha, herramientas y estrategias utilizadas para su solución(AU)


On December 2019, in Wuhan, China, there was an unusual increase in cases of a fast-progressing acute respiratory infection with high fatality rate. Soon after, the causing agent is identiied, a coronavirus called SARS-CoV-2, and a new disease, COVID-19 is characterized. Currently, in the absence of specific, effective and safe treatments, it is justified to explore all scientifically based alternatives available to us, such as the use of Convalescent Plasma (PC-CoV19) as acoadjutant treatment of COVID-19.Plasma from patients who have recovered from an infectious disease, Convalescent Plasma, has been used in the treatment of other infectious disease. There is recent history of its use in diseases caused by another type of coronavirus, and clinical experiences and studies have already been published with preliminary results during this pandemic. Quimbiotec, a Venezuelan State public company that produces blood products and recombinant drugs, and Banco Municipal de Sangre, deined a protocol to promote conditions for aphaeresis, processing, conservation, storage, distribution, transfusion, and evaluation of safety and eficacy of PC-CoV19 as an alternative for the treatment of COVID-19 in Venezuela. This protocol includes identification of capacities, physical structure, equipment and skills, talent, professionals needed, as well as a definition of processes to establish controlled and auditable routines to lay the foundations for access and use of PC-CoV19 in the Venezuela Health System, and prepare the design and implementation of clinical studies. The protocol and currently critical points in its implementation, as well as tools and strategies used for its solution, are presented(AU)


Assuntos
Humanos , Plasma/imunologia , Venezuela , Infecções por Coronavirus/prevenção & controle , Aprovação de Teste para Diagnóstico
19.
Rev Chilena Infectol ; 37(2): 117-123, 2020 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-32730476

RESUMO

BACKGROUND: The difference between the pathogenic isolates and commensals of Escherichia coli is based on their phylogenetic antecedents. In Venezuela there are few studies that describe the pathogenic potential of phylogenetic groups in E. coli. AIMS: Relate antimicrobial susceptibility, distribution of phylogenetic groups and virulence genes in strains of uropathogenic E. coli (ECUP) isolated from patients with UTI. METHODS: We studied 17 ECUP strains, isolated from adult patients hospitalized in two health institutions. The susceptibility to 8 antibiotics was determined by the broth microdilution (MDC) method. Extended spectrum ß-lactamases (ESBL) and carbapenemases were phenotypically detected. The phylogenetic groups and the detection of the virulence genes were determined by PCR. RESULTS: All strains synthesized ESBL and of these, 41% were associated with the production of a carbapenemases (KPC or MBL). The phylogroup B2 (41%) was the most predominant. The most frequent virulence genes were fimH and fyuA with 82% each. Only one strain from group F was positive to the 6 genes studied. DISCUSSION: The diversity of associations between virulence genes and resistance profiles in the ECUP are evolving continuously, their distribution in the different phylogenetic groups depends to a large extent on the clinical epidemiological characteristics of the study groups.


Assuntos
Infecções por Escherichia coli , Escherichia coli Uropatogênica , Adulto , Antibacterianos , Humanos , Filogenia , Infecções Urinárias , Escherichia coli Uropatogênica/genética , Venezuela , Fatores de Virulência , beta-Lactamases
20.
Ann Glob Health ; 86(1): 69, 2020 06 29.
Artigo em Inglês | MEDLINE | ID: mdl-32676298

RESUMO

Several characteristics of refugee and migrant populations make them susceptible to acquire COVID-19. To fully understand the impact of COVID-19 on refugees and migrants in the Americas, it is important to consider the broader geopolitical context and appreciate the differences among migratory groups. There are three migrant groups in the Americas that are particularly susceptible to COVID-19: Central American migrants at the northern Mexico border, Venezuelans within South America, and Haitians in the Dominican Republic. Refugees and displaced migrants are the world's collective responsibility, and thus, it would be imprudent to displace their care to resource constrained developing nations.


Assuntos
Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Refugiados , Migrantes , Betacoronavirus , América Central/etnologia , Países em Desenvolvimento , República Dominicana/epidemiologia , Haiti/etnologia , Humanos , México/epidemiologia , Pandemias , América do Sul/epidemiologia , Venezuela/etnologia , Populações Vulneráveis
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