Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.445
Filtrar
1.
Acta Odontol Latinoam ; 34(1): 104-1112, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-34570154

RESUMO

Great variation has been reported in worldwide prevalence of Molar Incisor Hypomineralization (MIH) and Hypomineralized Second Primary Molar (HSPM). South America has the highest regional prevalence. The aim of this study was to determine the prevalence and distribution of MIH HSPM in 6- to 12-year-old children who received care at two dental healthcare services (public and private) in Caracas Metropolitan Area, Venezuela. A cross-sectional prospective study was conducted on 145 children, of whom 121 were selected in the stratified random sample. A calibrated examiner (Kappa=0.878/0.831) evaluated all patients following the MIH diagnosis criteria established by the European Academy of Paediatric Dentistry and using a valid and reliable instrument. Data were analyzed with a significance level of 5%. Of the 121 children, 46.28% (56) were male and 53.72% (65) female, average age 8.83 ± 1.61. The prevalence of MIH/HSPM was 25.6%/20%. Both enamel defects were more prevalent in females (p-value=0.026/0.005). Severe MIH/HSPM was present in 21.8%/31.2% of cases. Average number of affected teeth was 4.16 ± 2.19/1.68 ± 0.74; and the condition was more frequent in upper molars (67.7%/51.4%). It was concluded that prevalence of MIH in 6- to 12-year-old Venezuelan children who received care in Caracas Metropolitan Area was higher than the previously estimated prevalence for South America, with predominance of mild affectation and more frequently occurring in upper molars.


Assuntos
Hipoplasia do Esmalte Dentário , Criança , Estudos Transversais , Assistência Odontológica , Hipoplasia do Esmalte Dentário/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Estudos Prospectivos , Venezuela/epidemiologia
2.
Acta Odontol Latinoam ; 34(2): 104-1112, 2021 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-34570857

RESUMO

Great variation has been reported in worldwide prevalence of Molar Incisor Hypomineralization (MIH) and Hypomineralized Second Primary Molar (HSPM). South America has the highest regional prevalence. The aim of this study was to determine the prevalence and distribution of MIH HSPM in 6- to 12-year-old children who received care at two dental healthcare services (public and private) in Caracas Metropolitan Area, Venezuela. A cross-sectional prospective study was conducted on 145 children, of whom 121 were selected in the stratified random sample. A calibrated examiner (Kappa=0.878/0.831) evaluated all patients following the MIH diagnosis criteria established by the European Academy of Paediatric Dentistry and using a valid and reliable instrument. Data were analyzed with a significance level of 5%. Of the 121 children, 46.28% (56) were male and 53.72% (65) female, average age 8.83 ± 1.61. The prevalence of MIH/HSPM was 25.6%/20%. Both enamel defects were more prevalent in females (p-value=0.026/0.005). Severe MIH/HSPM was present in 21.8%/31.2% of cases. Average number of affected teeth was 4.16 ± 2.19/1.68 ± 0.74; and the condition was more frequent in upper molars (67.7%/51.4%). It was concluded that prevalence of MIH in 6- to 12-year-old Venezuelan children who received care in Caracas Metropolitan Area was higher than the previously estimated prevalence for South America, with predominance of mild affectation and more frequently occurring in upper molars.


Assuntos
Hipoplasia do Esmalte Dentário , Criança , Estudos Transversais , Assistência Odontológica , Hipoplasia do Esmalte Dentário/epidemiologia , Feminino , Humanos , Masculino , Prevalência , Estudos Prospectivos , Venezuela/epidemiologia
5.
Acta Trop ; 222: 106034, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34224715

RESUMO

Trypanosoma cruzi uses various mechanisms of infection to access humans. Since 1967, food contaminated with metacyclic trypomastigotes has triggered several outbreaks of acute infection of Chagas disease by oral transmission. Follow-up studies to assess the effectiveness of anti-parasitic treatment of oral outbreaks are rather scarce. Here, we report a 10-year laboratory follow-up using parasitological, serological, and molecular tests of 106 individuals infected in 2007 of the largest known outbreak of orally transmitted Chagas disease, which occurred in Caracas city, Venezuela. Before treatment (2007), specific IgA, IgM and IgG, were found in 71% (75/106), 90% (95/106) and 100% (106/106), respectively, in addition to 21% (9/43) parasitemia, Complement Mediated Lysis (CML) in 98% (104/106) and 79% (34/43) parasitic DNA for PCR. Blood culture detected parasitemia up to 18 months post-treatment in 6% (6/106) of the patients. In 2017, the original number of cases in the follow-up decreased by 46% and due to the country's economic situation, not all the trials could be carried out in the entire population. During follow-up, IgA and IgM disappeared promptly, with IgM persisting in 19% (20/104) of the patients three years after treatment. The anti-T. cruzi IgG remained positive 10 years later in 41% (20/49) of the individuals evaluated. CML remained positive seven years later in 79% (65/82) of the cases. PCR positive cases decreased after treatment but progressively recovered, being positive in 69% (32/46) of the individuals evaluated in 2017. The group of children (under 18 years of age) showed the highest PCR positivity with 76% (26/34) of the cases, but their parasitic load tended to diminish, while in adults the parasitic load regained their initial values. The simultaneous evaluation of serological tests and PCR of the patients allowed us to separate patients among responders and non-responders to the anti-parasitic treatment, and this information prompted us to apply a second anti-parasitic treatment in the group of non-responders. In this population not subjected to the like lihood of re-infection, adult patients were more likely to be non-responders when compared to children. These results suggest that rigorous laboratory follow-up with T. cruzi infectious biomarkers is essential to detect cases of parasite persistence.


Assuntos
Doença de Chagas , Adulto , Anticorpos Antiprotozoários/análise , Biomarcadores , Doença de Chagas/diagnóstico , Doença de Chagas/tratamento farmacológico , Doença de Chagas/epidemiologia , Criança , Surtos de Doenças , Seguimentos , Humanos , Estudos Soroepidemiológicos , Falha de Tratamento , Venezuela/epidemiologia
6.
Malar J ; 20(1): 285, 2021 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-34174891

RESUMO

BACKGROUND: Fifty-three percent of all cases of malaria in the Americas in 2019 came from Venezuela, where the epidemic is heavily focused south of the Orinoco river, and where most of the country's Amerindian groups live. Although the disease is known to represent a significant public health problem among these populations, little epidemiological data exists on the subject. This study aims to provide information on malaria incidence, geospatial clustering, and risk factors associated to Plasmodium falciparum infection among these groups. METHODS: This is a descriptive study based on the analysis of published and unpublished programmatic data collected by Venezuelan health authorities and non-government organizations between 2014 and 2018. The Annual Parasite Index among indigenous groups (API-i) in municipalities of three states (Amazonas, Bolivar, and Sucre) were calculated and compared using the Kruskal Wallis test, risk factors for Plasmodium falciparum infection were identified via binomial logistic regression and maps were constructed to identify clusters of malaria cases among indigenous patients via Moran's I and Getis-Ord's hot spot analysis. RESULTS: 116,097 cases of malaria in Amerindian groups were registered during the study period. An increasing trend was observed between 2014 and 2016 but reverted in 2018. Malaria incidence remains higher than in 2014 and hot spots were identified in the three states, although more importantly in the south of Bolivar. Most cases (73.3%) were caused by Plasmodium vivax, but the Hoti, Yanomami, and Eñepa indigenous groups presented higher odds for infection with Plasmodium falciparum. CONCLUSION: Malaria cases among Amerindian populations increased between 2014 and 2018 and seem to have a different geographic distribution than those among the general population. These findings suggest that tailored interventions will be necessary to curb the impact of malaria transmission in these groups.


Assuntos
Malária Falciparum/epidemiologia , Plasmodium falciparum/isolamento & purificação , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Análise por Conglomerados , Feminino , Humanos , Incidência , Índios Sul-Americanos , Lactente , Recém-Nascido , Malária Falciparum/parasitologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Análise Espacial , Venezuela/epidemiologia , Adulto Jovem
7.
Cad Saude Publica ; 37(5): e00078820, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34076096

RESUMO

Historically, human migrations have determined the spread of many infectious diseases by promoting the emergence of temporal outbreaks between populations. We aimed to analyze health indicators, expenditure, and disability caused by tuberculosis (TB) and HIV/AIDS burden under the Colombian-Venezuelan migration flow focusing on the Northeastern border. A retrospective study was conducted using TB and HIV/AIDS data since 2009. We consolidated a database using official reports from the Colombian Surveillance System, World Health Organization, Indexmundi, the Global Health Observatory, IHME HIV atlas, and Joint United Nations Programme on HIV/AIDS (UNAIDS). Disability metrics regarding DALYs (disability adjusted life years) and YLDs (years lived with disability), were compared between countries. Mapping was performed on ArcGIS using official migration data of Venezuelan citizens. Our results indicate that TB profiles from Colombia and Venezuela are identical in terms of disease burden, except for an increase in TB incidence in the Colombian-Venezuelan border departments in recent years, concomitantly with the massive Venezuelan immigration since 2005. We identified a four-fold underfunding for the TB program in Venezuela, which might explain the low-testing rates for cases of multidrug-resistant TB (67%) and HIV/AIDS (60%), as well as extended hospital stays (150 days). We found a significant increase in DALYs of HIV/AIDS patients in Venezuela, specifically, 362.35 compared to 265.37 observed in Colombia during 2017. This study suggests that the Venezuelan massive migration and program underfunding might exacerbate the dual burden of TB and HIV in Colombia, especially towards the Colombian-Venezuelan border.


Assuntos
Infecções por HIV , Tuberculose , Brasil , Colômbia/epidemiologia , Emigração e Imigração , Infecções por HIV/epidemiologia , Humanos , Estudos Retrospectivos , Tuberculose/epidemiologia , Venezuela/epidemiologia
9.
Malar J ; 20(1): 186, 2021 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-33858446

RESUMO

BACKGROUND: Pregnant women are particularly vulnerable to malaria infections, increasing the risk of maternal-fetal complications, mainly in high-endemicity areas. However, few studies of malaria in pregnancy (MiP) have been carried out in Latin America, a region with low endemicity and transmission of both, Plasmodium falciparum and Plasmodium vivax. Despite the high malaria burden in Venezuela in the last years, no recent studies of MiP have been conducted. Hence, epidemiological and clinical characteristics of pregnant women with malaria in southern Venezuela are described herein. METHODS: A retrospective study in pregnant women attending at the "Ruíz y Páez" University Hospital Complex, Bolivar state, Venezuela, was carried out between February and October, 2019. Epidemiological, clinical, and laboratory information was analysed. RESULTS: Thirty-seven out of 52 pregnant women analysed were infected with P. vivax. Age ranged between 15 and 39 years, and adolescent pregnancies were common. Malaria infection was diagnosed mainly during the third trimester of pregnancy (63.4%). The distribution of symptoms and signs as well as clinical laboratory values was similar among Plasmodium spp. Although uncomplicated malaria was most frequent, 30% (13/52) had severe anaemia. A high proportion of studied women (44%) presented at least one complication during the pregnancy or delivery. Spontaneous abortion was recorded in four women, and three fetal deaths were observed. Six women had preterm delivery without any further complication. CONCLUSIONS: A high prevalence of maternal-fetal complications was found in the studied population, highlighting the requirement for a careful medical follow up during the prenatal check-ups, which should include routinary malaria tests. Preventive measures as distribution of insecticide-treated mosquito net for pregnant women at risk should also be implemented. Those measures can help to reduce the negative impact of malaria on the newborn and mother.


Assuntos
Plasmodium falciparum/fisiologia , Plasmodium vivax/fisiologia , Complicações Parasitárias na Gravidez/epidemiologia , Adolescente , Adulto , Feminino , Humanos , Malária Falciparum/epidemiologia , Malária Falciparum/parasitologia , Malária Vivax/epidemiologia , Malária Vivax/parasitologia , Gravidez , Complicações Parasitárias na Gravidez/parasitologia , Estudos Retrospectivos , Venezuela/epidemiologia , Adulto Jovem
10.
PLoS One ; 16(4): e0249022, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33857159

RESUMO

BACKGROUND: COVID-19 threatens health systems worldwide, but Venezuela's system is particularly vulnerable. To prevent the spread of COVID-19, individuals must adopt preventive behaviors. However, to encourage behavior change, we must first understand current knowledge, attitudes, and practices (KAPs) that inform response to this health threat. METHODS: We explored KAPs among Venezuelans using a cross-sectional, internet-based questionnaire. The questionnaire explored individuals' knowledge about COVID-19; their attitudes toward the world's and the Venezuelan authorities' abilities to control it; and their self-reported practices. We also collected demographic data. Binomial logistic regression analyses were used to predict the adoption of preventive behaviors based on demographic variables, individual knowledge level, and individual attitudes. RESULTS: 3122 individuals completed the questionnaire. Participants had a high level of knowledge about COVID-19. They expressed high levels of optimism that the world would eventually control COVID-19, but they were very pessimistic about the public authorities in Venezuela. Most participants adopted preventive practices. Binomial regression suggests younger people, less educated people, and manual laborers hold lower levels of knowledge, and these groups, as well as men, were less likely to adopt preventive practices. Knowledge, by itself, had no association with optimism and little association with self-reported practices. CONCLUSIONS: As other KAP studies in Latin America found, knowledge is not sufficient to prompt behavior change. Venezuelans' pessimism about their own country's ability should be explored in greater depth. Health promotion in Venezuela may wish to target the most at risk groups: men, younger people, less educated people, and manual laborers.


Assuntos
COVID-19/epidemiologia , Conhecimentos, Atitudes e Prática em Saúde , Adulto , COVID-19/prevenção & controle , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Autorrelato , Inquéritos e Questionários , Venezuela/epidemiologia
12.
Sci Rep ; 11(1): 6378, 2021 03 18.
Artigo em Inglês | MEDLINE | ID: mdl-33737710

RESUMO

In 2016, Venezuela faced a large diphtheria outbreak that extended until 2019. Nasopharyngeal or oropharyngeal samples were prospectively collected from 51 suspected cases and retrospective data from 348 clinical records was retrieved from 14 hospitals between November 2017 and November 2018. Confirmed pathogenic Corynebactrium isolates were biotyped. Multilocus Sequence Typing (MLST) was performed followed by next-generation-based core genome-MLST and minimum spanning trees were generated. Subjects between 10 and 19 years of age were mostly affected (n = 95; 27.3%). Case fatality rates (CFR) were higher in males (19.4%), as compared to females (15.8%). The highest CFR (31.1%) was observed among those under 5, followed by the 40 to 49 age-group (25.0%). Nine samples corresponded to C. diphtheriae and 1 to C. ulcerans. Two Sequencing Types (ST), ST174 and ST697 (the latter not previously described) were identified among the eight C. diphtheriae isolates from Carabobo state. Cg-MLST revealed only one cluster also from Carabobo. The Whole Genome Sequencing analysis revealed that the outbreak seemed to be caused by different strains with C. diphtheriae and C. ulcerans coexisting. The reemergence and length of this outbreak suggest vaccination coverage problems and an inadequate control strategy.


Assuntos
Corynebacterium diphtheriae/genética , Difteria/epidemiologia , Filogenia , Adolescente , Adulto , Criança , Pré-Escolar , Corynebacterium diphtheriae/isolamento & purificação , Corynebacterium diphtheriae/patogenicidade , Difteria/genética , Difteria/microbiologia , Surtos de Doenças , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Tipagem de Sequências Multilocus , Estudos Retrospectivos , Venezuela/epidemiologia , Adulto Jovem
14.
J Alzheimers Dis ; 82(s1): S263-S269, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33579837

RESUMO

BACKGROUND: Very few studies have investigated the association between total plasma homocysteine (tHcy) and depressive symptoms in older Hispanics. OBJECTIVE: To test the hypothesis that high tHcy associates with depressive symptoms in older Hispanics. METHODS: A total of 1,418 participants .55 years old from the Maracaibo Aging Study (MAS) underwent standardized neurological, neuropsychiatric, and cardiovascular assessments. The Neuropsychiatric Inventory Depression Subscale (NPId) was used to assess the burden of depressive symptoms. The tHcy levels and other biochemical parameters in blood samples were measured. Univariate and multivariate logistic regression models were applied. RESULTS: Participants with depressive symptoms had higher levels of tHcy than those without (15.1 versus 13.9 µmol/L; p = 0.009). Elevated tHcy levels were associated with depressive symptoms after adjusting for age, sex, education, smoking, diabetes, hypertension, alcohol intake, stroke, and dementia (OR = 1.58; 95% CI, 1.18-2.12). CONCLUSION: Elevated levels of tHcy were associated with depressive symptoms in older Hispanics living under the nutritional and environmental conditions of a developing country.


Assuntos
Envelhecimento/metabolismo , Envelhecimento/psicologia , Depressão/sangue , Depressão/psicologia , Hispano-Americanos/psicologia , Homocisteína/sangue , Idoso , Biomarcadores/sangue , Estudos de Coortes , Estudos Transversais , Depressão/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Venezuela/epidemiologia
15.
J Alzheimers Dis ; 82(s1): S251-S261, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33612541

RESUMO

BACKGROUND: Neuropsychiatric symptoms play an important role in diagnosing and clinical follow-up of cognitive impairment and dementia. OBJECTIVE: We investigated the relationship between neuropsychiatric symptoms, cognitive impairment, and dementia in Hispanics. METHODS: We included 529 participants (age ≥40 years) from the Maracaibo Aging Study with standardized neuropsychiatric assessments, including the Neuropsychiatric Inventory (NPI). Based on the Clinical Dementia Rating and the Mini-Mental State Examination scores, participants' cognitive status was categorized into normal cognition, mild/moderate, and severe cognitive impairment. Diagnosis of dementia was established in a consensus conference. Statistical analyses included multivariable logistic regression models and area under the curve (AUC). RESULTS: The mean age of participants was 59.3 years, and 71.8%were women. The proportion of dementia was 6.8%. Disturbed sleep, anxiety, and depression were the most common neuropsychiatric symptoms in the study sample. In crude analyses, the proportions of hallucinations, aberrant motor behavior, agitation/aggression, apathy, delusions, irritability, eating disturbance, depression, and euphoria were differently distributed among cognitive status groups (p < 0.05). After accounting for confounders, aberrant motor behavior and agitation/aggression remained significantly associated with cognitive impairment and dementia (p < 0.05). The inclusion of the NPI domains significantly improved the AUC to discriminate severe cognitive impairment and dementia compared to a basic model that included sex, age, education, alcohol, obesity, serum glucose, total cholesterol, hypertension, and stroke. CONCLUSION: Neuropsychiatric symptoms are associated with severe cognitive impairment and dementia. The addition of NPI items to the global cognitive assessment might help early detection of dementia in primary care settings.


Assuntos
Envelhecimento/psicologia , Hispano-Americanos/psicologia , Transtornos Mentais/epidemiologia , Transtornos Mentais/psicologia , Escalas de Graduação Psiquiátrica , Adulto , Idoso , Envelhecimento/patologia , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/epidemiologia , Disfunção Cognitiva/psicologia , Estudos Transversais , Demência/diagnóstico , Demência/epidemiologia , Demência/psicologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Transtornos Mentais/diagnóstico , Pessoa de Meia-Idade , Estudos Prospectivos , Venezuela/epidemiologia
16.
PLoS Negl Trop Dis ; 15(1): e0008211, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33493212

RESUMO

Malaria elimination in Latin America is becoming an elusive goal. Malaria cases reached a historical ~1 million in 2017 and 2018, with Venezuela contributing 53% and 51% of those cases, respectively. Historically, malaria incidence in southern Venezuela has accounted for most of the country's total number of cases. The efficient deployment of disease prevention measures and prediction of disease spread to new regions requires an in-depth understanding of spatial heterogeneity on malaria transmission dynamics. Herein, we characterized the spatial epidemiology of malaria in southern Venezuela from 2007 through 2017 and described the extent to which malaria distribution has changed country-wide over the recent years. We found that disease transmission was focal and more prevalent in the southeast region of southern Venezuela where two persistent hotspots of Plasmodium vivax (76%) and P. falciparum (18%) accounted for ~60% of the total number of cases. Such hotspots are linked to deforestation as a consequence of illegal gold mining activities. Incidence has increased nearly tenfold over the last decade, showing an explosive epidemic growth due to a significant lack of disease control programs. Our findings highlight the importance of spatially oriented interventions to contain the ongoing malaria epidemic in Venezuela. This work also provides baseline epidemiological data to assess cross-border malaria dynamics and advocates for innovative control efforts in the Latin American region.


Assuntos
Malária/epidemiologia , Malária/transmissão , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Emigração e Imigração , Feminino , Humanos , Incidência , Malária Falciparum/epidemiologia , Malária Vivax/epidemiologia , Masculino , Pessoa de Meia-Idade , Plasmodium vivax , Fatores Socioeconômicos , Venezuela/epidemiologia , Adulto Jovem
17.
Mult Scler Relat Disord ; 47: 102652, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33279797

RESUMO

BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD), is a rare autoimmune inflammatory disease of the central nervous system. Since the countries of Latin America (LATAM) show contrast in geographic, social, environmental factors, and genetic heterogeneity, the information about NMOSD epidemiology in the region allows a better understanding of the disease and its clinical outcome. OBJECTIVES: To determine the prevalence, relative frequency (RF), and clinical characteristics of NMOSD in a multiethnic Venezuelan cohort of patients with demyelinating disorders. METHODS: We conducted a retrospective descriptive multicenter study of hospital case records of individuals with an established diagnosis of MS and NMOSD in the National Program for Multiple sclerosis (MS) from 2011 to 2018. We selected those NMOSD cases based on the 2006 Wingerchuck and the 2015 International panel for the diagnosis of Neuromyelitis optica (IPND) criteria. RESULTS: We identified 249 patients with NMOSD. The prevalence was 2.11 per100,000 individuals (95% confidence interval (CI)1.85 2.37), the RF was 23%, and the MS/NMOSD ratio was 3.2:1. The average disease onset occurred by the fourth decade of life (34±14.8 years of age); with a strong female predominance (female to male ratio: 4:1). Mestizos constituted 86,7% of this cohort. Most of the patients presented initially with simultaneous optic neuritis (ON) and acute transverse myelitis (ATM) and a recurrent course was registered in 82.3% of cases. The mean of the expanded disability status scale (EDSS) was 3.5 (IQR 2-7). Abnormal brain and spine MRI were present in 47.8% and 81.1% of patients, respectively. Antibodies against aquaporin-4 (AQP4) which were measured through a cell-based assay were positive in 55.3% of the individuals tested. The most used immunosuppressant agent was Azathioprine (57.4%). CONCLUSION: NMOSD in Venezuela affects mainly young Mestizo women and shows one of the highest relative frequency in the region. Planning and developing healthcare programs for underserved populations as well as more comprehensive LATAM studies are required to identify the distribution and variations of its epidemiological picture.


Assuntos
Esclerose Múltipla , Neuromielite Óptica , Aquaporina 4 , Feminino , Humanos , Masculino , Esclerose Múltipla/epidemiologia , Neuromielite Óptica/epidemiologia , Estudos Retrospectivos , Venezuela/epidemiologia
18.
Rev Peru Med Exp Salud Publica ; 37(3): 412-422, 2020 Dec 02.
Artigo em Espanhol, Inglês | MEDLINE | ID: mdl-33295542

RESUMO

OBJECTIVE: To carry out a clinical-epidemiological analysis of high-density lipoprotein cholesterol subfractions (HDL-C) in adults from Maracaibo, Venezuela. MATERIALS AND METHODS: A descriptive and cross-sectional study of the database from the Metbolic Syndrome Prevalence in Maracaibo Study was carried out. HDL3 and HDL2 serum concentration, as well as the HDL2/HDL3 ratio, were determined in 359 individuals of both sexes, over 18 years of age. Values obtained were evaluated according to sociodemographic, clinical and biochemical characteristics. RESULTS: Mean population age was 39.4 ± 15.2 years, and 51.5% were female. Differences in HDL-C subfraction levels were only observed in those subjects with low HDL-C levels. Women with hypertriglyceridemia showed significantly lower serum HDL3 and HDL2 concentrations than those with normal triglycerides (p=0.033), as well as a lower HDL3 level and HDL2 / HDL3 ratio in those with higher levels of ultra-sensitive C-reactive protein (us-CRP) (p<0.001). A significantly lower concentration of HDL2 was observed in men with some degree of hypertension (p=0.031), insulin resistance (p=0.050) and metabolic syndrome (p=0.003); while those with elevated us-CRP showed a lower concentration of HDL3 (p=0.011). CONCLUSION: HDL-C subfractions show varying clinical-epidemiological behavior in adults from Maracaibo. Lower serum levels are observed in men, differences only in those with low HDL-C; and no predominance of any subclass was observed according to sociodemographic, clinical and biochemical characteristics.


Assuntos
HDL-Colesterol , Lipoproteínas HDL2 , Lipoproteínas HDL3 , Adulto , HDL-Colesterol/sangue , Cidades/epidemiologia , Estudos Transversais , Feminino , Humanos , Lipoproteínas HDL2/sangue , Lipoproteínas HDL3/sangue , Masculino , Pessoa de Meia-Idade , Venezuela/epidemiologia
19.
Global Health ; 16(1): 118, 2020 12 17.
Artigo em Inglês | MEDLINE | ID: mdl-33334370

RESUMO

BACKGROUND: Since 2016 Venezuela has seen a collapse in its economy and public health infrastructure resulting in a humanitarian crisis and massive outward migration. With the emergence of the novel coronavirus SARS-CoV-2 at the end of 2019, the public health emergency within its borders and in neighboring countries has become more severe and as increasing numbers of Venezuelans migrants return home or get stuck along migratory routes, new risks are emerging in the region. RESULTS: Despite clear state obligations to respect, protect and fulfil the rights to health and related economic, social, civil and political rights of its population, in Venezuela, co-occurring malaria and COVID-19 epidemics are propelled by a lack of public investment in health, weak governance, and violations of human rights, especially for certain underserved populations like indigenous groups. COVID-19 has put increased pressure on Venezuelan and regional actors and healthcare systems, as well as international public health agencies, to deal with a domestic and regional public health emergency. CONCLUSIONS: International aid and cooperation for Venezuela to deal with the re-emergence of malaria and the COVID-19 spread, including lifting US-enforced economic sanctions that limit Venezuela's capacity to deal with this crisis, is critical to protecting rights and health in the country and region.


Assuntos
COVID-19/prevenção & controle , Emigração e Imigração/estatística & dados numéricos , Direitos Humanos/normas , Malária/transmissão , COVID-19/epidemiologia , Recessão Econômica/estatística & dados numéricos , Direitos Humanos/tendências , Humanos , Malária/epidemiologia , Refugiados/estatística & dados numéricos , Venezuela/epidemiologia
20.
Av. odontoestomatol ; 36(4): 186-190, sept.-dic. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-198588

RESUMO

OBJETIVO: El objetivo de la presente investigación está enfocado en evaluar la calidad de vida relacionada con la salud oral en una población venezolana en el Perú. MATERIAL Y METODOS: Se trata de un estudio analítico transversal realizado entre los meses de setiembre a noviembre del 2019 a la población de nacionalidad venezolana. Participaron un total de 880 nacionales venezolanos quienes participaron voluntariamente del estudio, de los cuales 45.9% (379) eran de sexo femenino y 54.1% (501) de sexo masculino. Se realizó un examen clínico a fin de determinar las variables clínicas: el índice CPOD, el índice de higiene oral y el índice gingival. Para evaluar la calidad de vida relacionada con la salud oral se utilizó el Perfil de Impacto en la Salud Oral OHIP-14 que consta de 49 preguntas agrupadas en 7 dimensiones que son la limitación funcional, dolor físico, disconfort psicológico, incapacidad física, incapacidad psicológica, incapacidad física y en desventaja. Para si se da un puntaje de 1 y no 0. Así, a un mayor puntaje se obtiene la calidad de vida es peor. RESULTADOS: La relación de la calidad de vida con salud se verifica que un total del 27% (116.869) fueron respuestas positivas y un 72% (31,434) respuestas negativas. CONCLUSIONES: En relación a la calidad de vida relacionada con la salud oral se obtuvo que la población estudiada tiene buena calidad de vida, representada por más de la mitad de los encuestados


AIM: The objective of the present investigation is focused one valuating the quality of life related to oral health in a Venezuelan population in Peru. MATERIAL AND METHODS: This is a cross-sectional analytical study carried out between the months of September and November of 2019 to the population of Venezuelan nationality. A total of 880 Venezuelan nationals participated who voluntarily participated in the study, of which 45.9% (379) were female and 54.1% (501) male. A clinical examination was performed to determine the clinical variables: the CPOD index, the oral hygiene index and the gingival index. To assess the quality of life related to oral health, check the OHIP-14 Oral Health Impact Profile, which consists of 49 questions grouped into 7 dimensions that are functional limitation, physical pain, psychological distress, physical disability, psychological disability, physical and disadvantaged disability For itself a score of 1 is given and not 0. Thus, a higher score gets the quality of life is worse. RESULTS: The relationship of quality of life with health verifies that a total of 27% (116,869) were positive responses and 72% (31,434) negative responses. CONCLUSIONS: Regarding the quality of life related to oral health, it was obtained that the population studied has a good quality of life, represented by more than half of the respondents


Assuntos
Humanos , Saúde Bucal , Qualidade de Vida , Inquéritos de Saúde Bucal , Emigrantes e Imigrantes/estatística & dados numéricos , Doenças da Gengiva/epidemiologia , Peru/epidemiologia , Venezuela/epidemiologia , Estudos Transversais , Higiene Bucal
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...