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1.
Artigo em Chinês | MEDLINE | ID: mdl-31623053

RESUMO

SummaryAnalyze 2 cases of horizontal semicircular canals light cupulopathy patient history, clinical manifestations, vestibular function and hearing test results, summarize the clinical features of the disease. All of the 2 patients showed a typicaln light cupulopathy nystagmus. That is, the nystagmus of the Roll-Test test is sustained to the ground, and there is no latency and attenuation with null plane. When the patient's nystagmus is characterized by direction changing positional nystagmus and head deflection nystagmus disappearance(null plane), the possibility of horizontal semicircular canals light cupulopathy is to be thought of. In this paper, 2 cases of horizontal semicircular canals light cupulopathy received in our hospital are reported as follows.


Assuntos
Nistagmo Patológico , Canais Semicirculares , Humanos , Nistagmo Fisiológico , Testes de Função Vestibular , Vestíbulo do Labirinto
2.
Braz J Otorhinolaryngol ; 85(6): 788-798, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31606334

RESUMO

INTRODUCTION: People with vestibular loss present a deficit in the vestibular system, which is primarily responsible for promoting postural control, gaze stabilization, and spatial orientation while the head moves. There is no effective treatment for a bilateral loss of vestibular function. Recently, a vestibular implant was developed for people with bilateral loss of vestibular function to improve this function and, consequently, the quality of life of these patients. OBJECTIVE: To identify in the scientific literature evidence that vestibular implants in people with vestibular deficit improves vestibular function. METHODS: One hundred and forty six articles were found from five databases and 323 articles from the gray literature mentioning the relationship between vestibular implant and vestibular function in humans. The PICOS strategy (Population, Intervention, Comparison and Outcome) was used to define the eligibility criteria. The studies that met the inclusion criteria for this second step were included in a qualitative synthesis, and each type of study was analyzed according to the bias risk assessment of the Joanna Briggs Institute through the critical assessment checklist Joanna Briggs institute for quasi-experimental studies and the Joanna Briggs institute critical assessment checklist for case reports. RESULTS: Of the 21 articles included in reading the full text, 10 studies were selected for the qualitative analysis in the present systematic review. All ten articles analyzed through the critical assessment checklist Joanna Briggs institute showed a low risk of bias. The total number of samples in the evaluated articles was 18 patients with vestibular implants. CONCLUSIONS: Taken together, these findings support the feasibility of vestibular implant for restoration of the vestibulo-ocular reflex in a broad frequency range and illustrate new challenges for the development of this technology.


Assuntos
Implante Coclear , Doenças Vestibulares/cirurgia , Vestíbulo do Labirinto/fisiologia , Adulto , Distribuição por Idade , Idoso , Potenciais Evocados , Feminino , Humanos , Masculino , Doença de Meniere/fisiopatologia , Pessoa de Meia-Idade , Qualidade de Vida , Distribuição por Sexo , Doenças Vestibulares/fisiopatologia , Testes de Função Vestibular
3.
Exp Parasitol ; 206: 107768, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31539540

RESUMO

Canine leishmaniosis due to Leishmania infantum is a widespread zoonotic disease. Although aminosidine can be an effective treatment, current therapeutic recommendations do not advocate its use, mainly due to concerns regarding the potential nephrotoxicity and ototoxicity of this drug. The aim of this randomized, blinded, controlled study was to evaluate the nephrotoxicity and ototoxicity of aminosidine-allopurinol combination and compare it with that of meglumine antimonate-allopurinol combination in non-azotemic dogs with leishmaniosis. Forty dogs with leishmaniosis were randomly assigned to be treated with either aminosidine at 15 mg/kg, subcutaneously, once daily for 28 days (group A) or with meglumine antimonate at 100 mg/kg, subcutaneously, once daily for 28 days (group B). In addition to either drug, dogs in both groups were administered allopurinol at 10 mg/kg per os twice daily for 2 months. Kidney function was evaluated through measurement of serum creatinine, urea nitrogen, inorganic phosphorus, and cystatin-c concentrations and complete urinalysis, including protein-to-creatinine ratio, at baseline and after 14, 28, and 60 days from the beginning of the treatment. At the same time points, vestibular and auditory functions were evaluated through neurological examination and brainstem auditory evoked response (BAER) recordings of wave I, wave V, inter-wave I-V latencies, and minimum hearing thresholds. None of the dogs developed clinicopathological evidence of kidney disease during the study. Serum creatinine concentration increased >0.3 mg/dl over baseline in 2 dogs in group A and in 5 dogs in group B. Parameters of kidney function were not significantly different or were improved compared to baseline and the only difference between the two groups was the lower concentration of serum creatinine in group A. None of the dogs developed peripheral vestibular syndrome or hearing impairment. At the end of the study, parameters of auditory function were not significantly different or were improved compared to baseline and there were no differences between the two groups. The results of this study show that the nephrotoxicity and ototoxicity of aminosidine, when administered to non-azotemic dogs with leishmaniosis at 15 mg/kg subcutaneously once daily for 28 days along with allopurinol, is minimal and does not differ from that of meglumine antimonate.


Assuntos
Alopurinol/efeitos adversos , Doenças do Cão/tratamento farmacológico , Audição/efeitos dos fármacos , Rim/efeitos dos fármacos , Leishmaniose Visceral/veterinária , Paromomicina/efeitos adversos , Alopurinol/administração & dosagem , Alopurinol/uso terapêutico , Animais , Cóclea/efeitos dos fármacos , Creatinina/sangue , Doenças do Cão/parasitologia , Cães , Método Duplo-Cego , Combinação de Medicamentos , Potenciais Evocados Auditivos do Tronco Encefálico , Feminino , Perda Auditiva/induzido quimicamente , Perda Auditiva/veterinária , Injeções Subcutâneas/veterinária , Leishmania infantum , Leishmaniose Visceral/tratamento farmacológico , Masculino , Antimoniato de Meglumina/administração & dosagem , Antimoniato de Meglumina/efeitos adversos , Antimoniato de Meglumina/uso terapêutico , Exame Neurológico/veterinária , Paromomicina/administração & dosagem , Paromomicina/uso terapêutico , Distribuição Aleatória , Vestíbulo do Labirinto/efeitos dos fármacos
4.
Artigo em Chinês | MEDLINE | ID: mdl-31550769

RESUMO

Acid-sensing ion channels are a class of extracellular H(+) activated cation channels, belonging to the amiloride-sensitive epithelial Na(+) channel/degenerin (ENaC/DEG) superfamily. During extracellular acidification, the channels are activated and produce corresponding action potential. Acid-sensing ion channels are extensively expressed in the peripheral and central nervous system. It plays an important in synaptic plasticity, mechanical sensation, injury sensation related to acidosis of local tissues, acid reception and retinal regulation. This article reviews the expression, biological characteristics and functions of acid-sensing ion channels in cochlea, vestibular tissue and auditory center, so as to improve the understanding of physiology and pathophysiology of auditory system.


Assuntos
Canais Iônicos Sensíveis a Ácido , Córtex Auditivo , Cóclea , Vestíbulo do Labirinto , Canais Iônicos Sensíveis a Ácido/genética , Canais Iônicos Sensíveis a Ácido/metabolismo , Córtex Auditivo/fisiologia , Cóclea/fisiologia , Humanos , Sensação , Vestíbulo do Labirinto/fisiologia
5.
Vestn Otorinolaringol ; 84(3): 61-64, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31486430

RESUMO

A case of perilymphatic fistula with the luxation of the stapes into vestibule was described, which was caused by a direct damage of the eardrum (the patient cleaned the right ear with a cotton swab and received a strong blow to the arm). The moment of injury was characterized by severe pain, a significant hearing loss, the appearance of tympanophonia and vertigo. Clinical examination revealed the eardrum rupture. After perforation healing the hearing did not improve, a high degree of mixed sensorineural hearing loss remained with a bone-air interval of up to 50 dB throughout the tone scale. CT of the temporal bones showed a pneumolabirinth and a change in the malleus position, which made it possible to suggest the presence of a perilymphatic fistula with the luxation of the stapes. The extent of damage was confirmed by surgery. The stapes was removed and the perilymphatic fistula was closed.


Assuntos
Fístula , Cirurgia do Estribo , Doenças Vestibulares , Vestíbulo do Labirinto , Humanos , Estribo , Vertigem
6.
Int J Pediatr Otorhinolaryngol ; 125: 201-205, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31401454

RESUMO

Many studies showed that children with sensorineural hearing loss (SNHL) have possible vestibular affection which is related to the severity of cochlear pathology. OBJECTIVES: this work is designed to evaluate vestibular function in children with congenital severe to profound SNHL and correlate the degree of hearing loss with the results of vestibular tests. METHODS: this work included 52 children divided into two groups; control group consisted of 20 normal hearing children with no vestibular complaints, and study group consisted of 32 children with congenital severe to profound SNHL. All children were submitted to basic audiologic evaluation, combined vestibular evoked myogenic potentials, sinusoidal harmonic acceleration test (SHA) of rotatory chair test. RESULTS: all children in the control group had normal oVEMP and cVEMPs results while abnormal cVEMPs and oVEMPs results were found in 89% and 96.9% of the tested ears of the study group respectively. Sinusoidal harmonic acceleration test results were normal in control group with significant reduction in gain, phase lead and higher level of asymmetry in 50% of the children in study group. There was a significant relation between the degree of hearing loss and the cVEMPs, oVEMPs abnormalities, while SHA test results showed no such relationship. CONCLUSION: There is an evident vestibular abnormalities in children with severe to profound sensorineural hearing loss as revealed by the rotatory chair testing and VEMPs recordings. Vestibular assessment is very important in such group as it has an impact on their rehabilitation plan.


Assuntos
Perda Auditiva Neurossensorial/complicações , Perda Auditiva Neurossensorial/fisiopatologia , Doenças Vestibulares/complicações , Potenciais Evocados Miogênicos Vestibulares/fisiologia , Adolescente , Estudos de Casos e Controles , Criança , Feminino , Perda Auditiva Neurossensorial/diagnóstico , Humanos , Masculino , Doenças Vestibulares/diagnóstico , Doenças Vestibulares/fisiopatologia , Vestíbulo do Labirinto/fisiopatologia
7.
Zhonghua Yi Xue Za Zhi ; 99(28): 2197-2202, 2019 Jul 23.
Artigo em Chinês | MEDLINE | ID: mdl-31434392

RESUMO

Objective: To explore the possible causes and mechanisms of sudden deafness with vertigo. Methods: Between August 2016 and December 2017, 74 patients with sudden deafness and vertigo were hospitalized in the Department of Otolaryngology, First Affiliated Hospital of Sun Yat-sen University. Among them, 36 were male and 38 were female, aged 18-75 (40.5±6.5) years. According to the results of magnetic resonance imaging (MRI), the patients were divided into two groups: internal ear hemorrhage (IEH) and non-IEH (NIEH). The characteristics of deafness, vertigo, laboratory examination and follow-up results were compared between the two groups. Results: In IEH group, deafness and vertigo occurred simultaneously in 22 cases (84.6%), abnormalities of semicircular canal function, cervical vestibular evoked myogenic potential (C-VEMP), ocular vestibular evoked myogenic potential (O-VEMP) in 26 cases (100%) and benign paroxysmal positional vertigo (BPPV) in 10 cases (38.5%). The total effective rate was 19.2% (5/26) after 14 days of treatment, and 11 cases (42.3%) appeared disturbance after 180 days of treatment. The abnormal rate of lateral vestibular function, C-VEMP and O-VEMP was 69.2% (18/26), 53.8% (14/26) and 57.7% (15/26) respectively. The improvement of hearing threshold was (28.6±9.7) dB. In NIEH group, deafness and vertigo occurred simultaneously in 25 cases (52.1%). The abnormalities of semicircular canal function, C-VEMP and O-VEMP happened in 37 cases (77.1%), 34 cases (70.8%), 26 cases (54.2%), respectively, and 6 cases (12.5%) were of BPPV. The total effective rate was 52.1% (25/48) after 14 days of treatment. After 180 days of treatment, 8 cases (16.7%) were out of balance, and the abnormal rate of lateral vestibular function, C-VEMP and O-VEMP were 31.2% (15/48), 25.0% (12/48) and 20.8% (10/48) respectively. The improvement of hearing threshold was (42.5±10.3) dB. The incidence of stimulantous deafness and vertigo, vestibular dysfunction rate, BPPV incidence rate and the total effective rate after 14 days of treatment were significantly different between the two groups (all P<0.05). The vestibular and cochlear dysfunction in IEH group was more serious than that in NIEH group. After 180 days of treatment, the vestibular dysfunction rate, imbalance rate and improvement of hearing threshold in NIEH group were significantly higher than that in IEH group (all P<0.05). The recovery of vestibular and cochlear function in NIEH group was better than that in IEH group. Conclusions: Sudden deafness with vertigo can cause vestibular and cochlear dysfunction. Different etiologies may lead to different clinical features and prognosis. The vestibular and cochlear function damage caused by inner ear hemorrhage was more serious and the recovery effect was poor.


Assuntos
Perda Auditiva Neurossensorial , Perda Auditiva Súbita , Vestíbulo do Labirinto , Adolescente , Adulto , Idoso , Vertigem Posicional Paroxística Benigna , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Canais Semicirculares , Adulto Jovem
8.
Int J Pediatr Otorhinolaryngol ; 125: 206-211, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31415955

RESUMO

OBJECTIVES: The video-Head-Impulse-Test (vHIT) is widely used to evaluate vestibular function. Nevertheless, there is no consensus on the necessary or ideal number of impulses performed for robust VOR gains. Therefore, the aim of our study is to analyze how many impulses are needed to receive reliable VOR gains in difficult testing situations like testing children younger than 48 months and in children with vestibular loss. METHODS: A retrospective data analysis was performed in which existing vHIT results of 25 healthy children aged 5-48 months were included as well as vHIT results of 25 children with vestibular loss aged 2-16 years. Descriptive data analysis was performed and further statistical analysis was conducted to determine if the number of head impulses could be reduced using internal consistency (Cronbach's alpha) and paired t-test. RESULTS: Median gain was 0.95 (±0.16) for impulses to the right and 0.97 (±0.16) for impulses to the left in healthy children and ranged from 0.01 (±0.11) to 0.75 (+/- 0.23) in children with vestibular hypfunction. Analyzing Cronbach's Alpha, a 99.6% (α = 0.996) true score variance was achieved when two impulses were performed to the right and 98,1% to the left in healthy children and 99.9% in children with impaired vestibular function. CONCLUSION: These results indicate that two high velocity artifact-free impulses from an experienced tester are sufficient to evaluate vestibular function in difficult vHIT testing conditions like testing very young children. Further impulses do not improve test reliability.


Assuntos
Teste do Impulso da Cabeça , Doenças Vestibulares/diagnóstico , Adolescente , Artefatos , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Reflexo Vestíbulo-Ocular/fisiologia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Canais Semicirculares/fisiopatologia , Vestíbulo do Labirinto/fisiopatologia , Gravação em Vídeo
9.
Gait Posture ; 74: 40-44, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31442821

RESUMO

BACKGROUND: Cochlear implantation (CI) procedure carries the potential risk for vestibular system insult or stimulation with resultant dysfunction due to its proximity to the cochlea. The vestibular system plays an essential role in crucial tasks such as postural control, gaze stabilization and spatial orientation. RESEARCH QUESTION: How does standard cochlear implantation influence postural stability in patients with hearing loss? METHODS: The study included 21 individuals (age 51 ± 18 years) qualified to undergo CI due to severe or profound hearing loss. Participants were qualified for both groups by a physician based on an interview, an otoneurological examination and vestibular tests. The first group included patients without vestibular dysfunction, whereas the other group consisted of persons with vestibular dysfunction. The research methodology included medical examinations, anthropometric measurements and stabilometry on the Biodex Balance System SD (BBS) platform. The examinations were carried out twice, i.e. prior to and 3 months post implantation. The recorded data was compared between the first and the second examination using a non-parametric Wilcoxon test. The analysis of variance (ANOVA) and Tukey's post-hoc HSD unequal sample sizes were performed for patients with and without vestibular dysfunction. RESULTS AND SIGNIFICANCE: Study showed that 52.4% of the participants obtained results within the norm, while 47.6% scored below it. The comparison of stability indices of the examined individuals, with and without vestibular dysfunction, did not reveal statistically significant differences. The only difference was the anterior-posterior stability index assessed in static conditions. Three months after the implantation, no changes in the majority of indices were noted, with the exception of anterior-posterior stability index, which improved following the implantation. CI does not affect postural stability changes in the study participants.


Assuntos
Implante Coclear/efeitos adversos , Implantes Cocleares/efeitos adversos , Perda Auditiva , Equilíbrio Postural/fisiologia , Adulto , Idoso , Análise de Variância , Feminino , Perda Auditiva/fisiopatologia , Perda Auditiva/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Vestíbulo do Labirinto/lesões
10.
Gait Posture ; 73: 215-220, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31376748

RESUMO

BACKGROUND: Postural stability depends on the integration of the multisensory system to produce motor outputs. When visual and somatosensory input is reliable, this reduces reliance on the vestibular system. Despite this, vestibular loss can still cause severe postural dysfunction. Training one or more of the three sensory systems through vestibular habituation and adaptation can alter sensory weighting and change postural behavior. AIM: The purpose of this study was to assess sensory reweighting of postural control processing after combined vestibular activation with voluntary weight shift training in healthy adults. METHODS: Thirty-three healthy individuals (18-35 y.o.) were randomly assigned to one of three groups: No training (control), visual feedback weight shift training (WST) coupled with an active horizontal headshake (HS) activity to elicit a vestibular perturbation, or the same WST without HS (NoHS). Training was performed 2x/day, every other day (M, W, F), totaling six sessions. Pre- and post- assessments on the Sensory Organization Test (SOT) were performed. Separate between- and within- repeated measures ANOVAs were used to analyze the six SOT equilibrium scores, composite scores, sensory ratios and center of pressure (COP) variables by comparing baseline to post-training. Alpha level was set at p < .05. RESULTS: There was a significant group x session x condition change (p = .012) in the COP multiscale entropy (MSE) velocity sway in the HS group during SOT conditions 5 and 6. Similarly, COP medio-lateral standard deviation sway (ML Std) showed group x session x visual condition (p = .028), due to HS in condition 6 relative to other two groups. CONCLUSION: Postural training can alter sensory organization after a visual feedback-vestibular activation training protocol, suggesting a possible sensory reweighting through vestibular adaptation and/or habituation. SIGNIFICANCE: Translating these findings into a vestibular-impaired population can stimulate the design of a rehabilitation balance protocol.


Assuntos
Modalidades de Fisioterapia , Equilíbrio Postural/fisiologia , Vestíbulo do Labirinto/fisiologia , Adaptação Fisiológica , Adolescente , Adulto , Retroalimentação Sensorial/fisiologia , Feminino , Humanos , Masculino , Adulto Jovem
11.
J Laryngol Otol ; 133(8): 668-673, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31309905

RESUMO

OBJECTIVE: To determine the impact of pre-operative intratympanic gentamicin injection on the recovery of patients undergoing translabyrinthine resection of vestibular schwannomas. METHODS: This prospective, case-control pilot study included eight patients undergoing surgical labyrinthectomy, divided into two groups: four patients who received pre-operative intratympanic gentamicin and four patients who did not. The post-operative six-canal video head impulse test responses and length of in-patient stay were assessed. RESULTS: The average length of stay was shorter for patients who received intratympanic gentamicin (6.75 days; range, 6-7 days) than for those who did not (9.5 days; range, 8-11 days) (p = 0.0073). Additionally, the gentamicin group had normal post-operative video head impulse test responses in the contralateral ear, while the non-gentamicin group did not. CONCLUSION: Pre-operative intratympanic gentamicin improves the recovery following vestibular schwannoma resection, eliminating, as per the video head impulse test, the impact of labyrinthectomy on the contralateral labyrinth.


Assuntos
Gentamicinas/administração & dosagem , Neuroma Acústico/terapia , Procedimentos Cirúrgicos Otológicos/métodos , Vestíbulo do Labirinto/cirurgia , Adulto , Estudos de Casos e Controles , Feminino , Teste do Impulso da Cabeça , Humanos , Injeção Intratimpânica , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Centros de Atenção Terciária
12.
Acta Otolaryngol ; 139(9): 759-768, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31311369

RESUMO

Objectives: To determine the incidence of gentamicin vestibulotoxicity with current dosing regimens, and to evaluate the feasibility of routine video-oculography on all patients given gentamicin. Materials and methods: In this prospective incidence study serial horizontal vestibulo-ocular reflex (HVOR) gain measurements were recorded using video-oculography on adult inpatients receiving intravenous gentamicin. The primary outcome was the proportion of patients developing impairment of their HVOR gain. Results: After exclusions, 42 patients were included in the analysis. Three patients (7.1%) developed asymptomatic vestibulotoxicity, exact 95% confidence interval 1.5-19.5%. In two of these patients the deficit resolved within several hours. No patients developed symptomatic vestibulotoxicity. There was no evidence for a generalised reduction in group HVOR gain with time. HVOR gain was not associated with total gentamicin dose, dynamic visual acuity or subjective imbalance. Conclusions and significance: Gentamicin may cause reversible, asymptomatic vestibulotoxicity. Video-oculography may be useful to monitor for vestibulotoxicity in patients treated with gentamcin; however, testing all patients routinely may be challenging.


Assuntos
Gentamicinas/efeitos adversos , Reflexo Vestíbulo-Ocular/efeitos dos fármacos , Vestíbulo do Labirinto/efeitos dos fármacos , Gravação em Vídeo , Adulto , Estudos de Coortes , Relação Dose-Resposta a Droga , Esquema de Medicação , Feminino , Gentamicinas/uso terapêutico , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Nova Zelândia , Estudos Prospectivos , Medição de Risco , Centros de Atenção Terciária , Doenças Vestibulares/induzido quimicamente
13.
BMJ Case Rep ; 12(7)2019 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-31270089

RESUMO

Third window defects have increasingly been identified as a cause of vertigo. These defects are bony dehiscences that occur in the bony labyrinth, resulting in abnormal pressure gradient in the inner ear fluids leading to sound (Tullio's phenomenon) or pressure (Hennebert's sign) induced vertigo. The superior semicircular canal dehiscence syndrome is a well-described entity in this regard, however defects of the posterior semicircular canal are rare and may have overlapping symptomatology. We describe the history, clinical profile and management of a patient who had importunate symptoms despite being on conservative management for a year and had resolution of vestibular symptoms following surgical management.


Assuntos
Doenças do Labirinto/diagnóstico por imagem , Doenças do Labirinto/cirurgia , Canais Semicirculares/diagnóstico por imagem , Canais Semicirculares/cirurgia , Humanos , Doenças do Labirinto/patologia , Masculino , Pessoa de Meia-Idade , Canais Semicirculares/patologia , Tomografia Computadorizada por Raios X/métodos , Vestíbulo do Labirinto/diagnóstico por imagem , Vestíbulo do Labirinto/patologia , Vestíbulo do Labirinto/cirurgia
14.
Artigo em Chinês | MEDLINE | ID: mdl-31262108

RESUMO

Objective: To introduce the method of galvanic vestibular stimulation-vestibular evoked myogenic potentials (GVS-VEMP) as well as to observe and analyze the parameters and elicited rate of GVS-cVEMP and GVS-oVEMP in healthy young people in China. Methods: Twenty six normal young subjects were recruited for conventional examinations of GVS-VEMP. The subjects were 21-37 years old, average age was (25.8±3.7) years old, including 13 males and 13 females. The galvanic stimulation intensity of 3 mA/1 ms was used to evoke cVEMP and oVEMP on the sternocleidomastoid and inferior extraocular muscles respectively, and the intensity of stimulus was decreased until the response disappeared, the threshold, latency, amplitude, interval phase and interaural amplitude ratio(IAR) were calculated. SPSS18.0 software was used for statistical analysis. Results: All subjects were elicited normal GVS-cVEMP and GVS-oVEMP under 3 mA/1 ms, the elicited rate was 100%. The threshold of GVS-cVEMP was (1.18±0.47) mA, p1 latency was (10.43±1.54) ms, n1 latency was (17.91±1.20) ms, the amplitude was (102.47±56.77) uV and IAR was (0.26±0.20). The threshold of GVS-oVEMP was (1.12±0.50) mA, n1 latency was (8.46±1.05) ms, p1 latency was (11.83±1.27) ms, the amplitude was (9.12±6.82) uV and IAR was (0.25±0.20). In terms of gender and lateral comparison, only the GVS-oVEMP amplitude was higher for male than for female, which had significant statistical difference (P<0.05), and there was no statistical difference in the other parameters between GVS-cVEMP and GVS-oVEMP. Conclusion: GVS-cVEMP and GVS-oVEMP could be elicited in healthy youth population, and the parameters could provide reference for subsequent vestibular function evaluation.


Assuntos
Estimulação Acústica/métodos , Músculos do Pescoço/fisiologia , Músculos Oculomotores/fisiologia , Potenciais Evocados Miogênicos Vestibulares/fisiologia , Vestíbulo do Labirinto/fisiologia , Adulto , Feminino , Voluntários Saudáveis , Humanos , Masculino , Vestíbulo do Labirinto/fisiopatologia , Adulto Jovem
15.
Artigo em Chinês | MEDLINE | ID: mdl-31163519

RESUMO

Objective:To explore the clinical effect of vestibular rehabilitation on vestibular neuritis. Method:Fifty patients with vestibular neuritis (VN) were randomly divided into study group (n=26) and control group (n=24). The patient in study group received methylprednisolone treatment and peripheral vestibular rehabilitation therapy, while that in the control group received methylprednisolone only. Spontaneous nystagmus (SN), caloric test (CP), directional preponderance (DP),vestibular muscle evoked potential (VEMP) were comparative for study group and control group at admission, 1 month after treatment, and 3 months after treatment. Result:①There was no significant difference in the balance between the two groups. ②After 1 month treatment, the directional preponderance of DP decreased (P<0.01) in the study group(21.09±16.90)% compared with the control group(41.11±24.03)%, VEMP extraction rate increased (P<0.05) in the study group compared with the control group, dynamic balance score of the study group (70.77±16.15) increased (P<0.05) compared with the control group (53.83±26.76). ③After 3 months, canal paresis CP of the study group (33.26±20.01)% decreased (P<0.05) compared with the control group (50.07±25.42)%, DP of the study group (8.63±5.65)% decreased (P<0.01) compared with the control group (17.98±8.84)%, and the comprehensive dynamic balance score of the study group (81.58±3.67) increased (P<0.01) compared with the control group (62.50±29.24). Conclusion:Peripheral vestibular rehabilitation can accelerate vestibular compensation and is an effective treatment for vestibular neurons.


Assuntos
Glucocorticoides , Metilprednisolona , Nistagmo Patológico , Neuronite Vestibular , Vestíbulo do Labirinto , Testes Calóricos , Glucocorticoides/uso terapêutico , Humanos , Metilprednisolona/uso terapêutico , Neuronite Vestibular/tratamento farmacológico
16.
Artigo em Chinês | MEDLINE | ID: mdl-31163523

RESUMO

Objective:To study the etiology of vertigo in children and analyze the relationship between the etiology of vertigo and the age category. Method:One hundred and forty-four cases of children with vertigo or dizziness were selected. All patients received the vertigo questionnaire, audiological, vestibular function and other related examinations. JMP 10.0 was used for statistical analysis. Result:Of 144 patients, 17 cases were preschool age (<6 years old), 101 cases were school age (6-12 years old) and 26 cases were puberty (>12 years old). All patients were mainly distributed between 6 and 10 years old. The most common diagnoses was benign paroxysmal vertigo. The second one was vestibular migraine. Incidence rate of the same disease in different ages was also different. Benign paroxysmal vertigo and vestibular migraine in preschool age, school age and puberty accounted for 58.8%, 42.6%, 0 and 0, 17.8%, 30.8%, respectively. Conclusion:Benign paroxysmal vertigo and vestibular migraine were the most common causes of vertigo in children. Prevalence rate and the etiology was various in different ages. Due to the physical and psychological development of children, analyzing the cause of vertigo in children should be fully considered these characteristics.


Assuntos
Vertigem Posicional Paroxística Benigna , Transtornos de Enxaqueca , Vestíbulo do Labirinto , Vertigem Posicional Paroxística Benigna/complicações , Vertigem Posicional Paroxística Benigna/epidemiologia , Criança , Pré-Escolar , Tontura , Humanos , Transtornos de Enxaqueca/complicações , Prevalência , Puberdade
17.
J Laryngol Otol ; 133(7): 554-559, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31196230

RESUMO

OBJECTIVE: To determine whether central findings from vestibular tests predict abnormal findings on magnetic resonance imaging. METHOD: This study was a retrospective case series at a tertiary referral centre. The main outcome measure of this diagnostic intervention study was the positive predictive value of central vestibular findings in relation to magnetic resonance imaging abnormalities. RESULTS: Central vestibular findings had a 50.9 per cent positive predictive value for magnetic resonance imaging abnormalities across all age groups although they varied according to age group. Optokinetic nystagmus (p < 0.05) and abnormal findings on videonystagmography tests (p < 0.05) were the main predictors of magnetic resonance imaging abnormalities. White matter lesions constituted the bulk of the central lesions on magnetic resonance imaging followed by cortical and cerebellar atrophy. CONCLUSION: Central vestibular findings had a 50.9 per cent positive predictive value for magnetic resonance imaging abnormalities across all age groups. Magnetic resonance imaging is medically justified to further evaluate patients with central findings on vestibular studies. Therefore, it is reasonable to request magnetic resonance imaging in these patients.


Assuntos
Encéfalo/diagnóstico por imagem , Eletronistagmografia/métodos , Imagem por Ressonância Magnética/métodos , Nistagmo Patológico/diagnóstico por imagem , Vertigem/diagnóstico por imagem , Vestíbulo do Labirinto/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Retrospectivos , Centros de Atenção Terciária , Testes de Função Vestibular , Gravação em Vídeo , Adulto Jovem
18.
Acta Bioeng Biomech ; 21(1): 73-78, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31197286

RESUMO

PURPOSE: The aim of the study was to determine balance parameters in a group of young patients with vertigo symptoms and to verify posturography helpfulness in clinical evaluation of vestibular system pathology. METHODS: 77 children and adolescents of age 3-18 suffering from vertigo episodes participated in the study (46 girls, 31 boys). They underwent audiology objective tests and balance test on stable surface. Calculated balance parameters were analyzed in reference to: eyes opened and closed, age influence, sway comparison in anterior-posterior and medial-lateral, differences between subgroups with and without vestibular deficits. Discriminant analysis was performed to assess classification ability to impaired group in two cases: only balance parameters and both audiology and balance parameters. RESULTS: Patients with vertigo symptoms generally keep their balance properly on stable surface. Balance parameters do not depend on presence of vestibular system pathology. Values increased in eyes closed conditions. Left/Right and Anterior/Posterior differences were not statistically significant. The negative correlation between age and some balance parameters is present, stronger in the case of eyes opened and weaker or absent in vestibular impaired group. Also, correlations between axes were found, higher in impaired group in comparison with not impaired one. CONCLUSIONS: Discrimination based on balance parameters is poor not comparable to one built on combined: audiology and balance parameters, so typical balance parameters' analysis is not so useful in clinical practice when the reason of vertigo episodes should be assessed, but verify compensation process and measure with objective numbers the progress of recovering, the actual functional patient's status.


Assuntos
Equilíbrio Postural/fisiologia , Vertigem/fisiopatologia , Vestíbulo do Labirinto/patologia , Vestíbulo do Labirinto/fisiopatologia , Adolescente , Criança , Pré-Escolar , Análise Discriminante , Feminino , Humanos , Masculino
19.
Clin J Sport Med ; 29(4): 318-323, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31241535

RESUMO

OBJECTIVE: To compare vestibular dysfunction at 1 to 10 and 11 to 20 days following sport/recreation-related concussion (SRC) in athletes with and without history of motion sickness susceptibility. Secondary aims of this study were to investigate differences in neurocognitive performance and affective symptoms in these groups. DESIGN: Cross-sectional. SETTING: Concussion Specialty Clinic. PARTICIPANTS: One hundred twenty-four adolescents and adults (82 males, 42 females) aged 14 to 26 (16.36 ± 2.10) years, diagnosed with SRC in the past 10 (4.56 ± 2.54) days; 47 participants composed the sample for quartile analyses. INDEPENDENT VARIABLE: Motion sickness susceptibility questionnaire short form score. MAIN OUTCOME MEASURES: Computerized neurocognitive test scores, vestibular/oculomotor screening scores (VOMS), and symptom factor scores from a standardized concussion symptom inventory. RESULTS: There was no association between history of motion sickness susceptibility and VOMS scores (above or below clinical cutoff) at 1 to 10 days after injury, although at 11 to 20 days after injury there was an association between high motion sickness susceptibility and symptoms above clinical cutoff on 5 of the 6 VOMS items (P values 0.01-0.04). The high motion sickness group had more affective symptoms on the symptom inventory than the no motion sickness group (P = 0.002) at 1 to 10 days after injury. Groups did not differ on computerized neurocognitive testing (P = 0.11). CONCLUSION: Athletes with a preexisting history of motion sensitivity may exhibit more prolonged vestibular dysfunction following SRC, and may experience more affective symptoms early in recovery.


Assuntos
Traumatismos em Atletas/complicações , Concussão Encefálica/complicações , Enjoo devido ao Movimento/etiologia , Adolescente , Adulto , Atletas , Estudos Transversais , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Vestíbulo do Labirinto/fisiopatologia , Adulto Jovem
20.
Exp Brain Res ; 237(9): 2185-2196, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31214739

RESUMO

Our recent work demonstrated that vision can recalibrate the vestibular signal used to re-establish equilibrium following a platform perturbation. Here, we investigate whether vision provided during a platform perturbation can recalibrate the use of vestibular reafference during the dynamic phase of the perturbation response. Dynamic postural responses were examined during a series of five forward perturbations to the body, while galvanic vestibular stimulation (GVS) selectively altered vestibular feedback and LCD occlusion spectacles controlled visual availability. Responses with and without vision were compared. The presence of GVS caused 1.78 ± 0.19 cm of medio-lateral (ML) body motion toward the anode during the initial 3 s of the dynamic postural response across perturbations. This dynamic ML response was attenuated across perturbations 1-3 independent of visual availability, resulting in a significant reduction of ML center of mass and pressure deviations (p < 0.01, ƞ2 = 0.27). That is, the vestibular influence on the ML perturbation response could be altered but vision was not necessary for this adaptation. After removing GVS, the ML response component reversed in direction toward the cathode with a magnitude that was not significantly different to the amount of response attenuation seen when GVS was present (- 0.95 ± 0.19 cm; p = 0.99, ƞ2 = 0.00). This suggested that the use of a GVS-altered vestibular signal during dynamic perturbation responses could be recalibrated, but that visual feedback was likely not responsible. Alternative mechanisms to explain the recalibration process are discussed.


Assuntos
Retroalimentação Sensorial/fisiologia , Equilíbrio Postural/fisiologia , Vestíbulo do Labirinto/fisiologia , Percepção Visual/fisiologia , Adulto , Estimulação Elétrica , Feminino , Humanos , Masculino , Adulto Jovem
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