Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 399
Filtrar
1.
Ned Tijdschr Tandheelkd ; 127(10): 573-580, 2020 Oct.
Artigo em Holandês | MEDLINE | ID: mdl-33156300

RESUMO

The relationship between xerostomia and reduced saliva secretion is known to occur in patients suffering from dry mouth. These are mainly (frail) older people experiencing reduced saliva secretion as a result of the use of medication. In the current research, we investigated whether the severity of xerostomia could be used as predictor for saliva secretion in young adults. 369 dentistry students participated in this study, of whom 33.4% were male and 66.6% were female, with an average age of 20.2 ± 2.4 years. It was found that the severity of xerostomia in the young adult students had a weak correlation with the unstimulated saliva secretion rate. This indicates that dry mouth complaints in this age group are not a good predictor for saliva secretion. In addition, it is concluded that hyposalivation is not restricted to older people or to specific patient groups, but that even among a trial population of young adults, individuals can suffer from dry mouth and/or reduced saliva secretion.


Assuntos
Saliva , Xerostomia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Taxa Secretória , Xerostomia/epidemiologia , Adulto Jovem
2.
Am J Otolaryngol ; 41(6): 102721, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32977063

RESUMO

BACKGROUND: The novel Coronavirus Disease-19 (COVID-19) continues to have profound effect on global health. Our aim was to evaluate the prevalence and characterize specific symptoms associated with COVID-19. METHODS: This retrospective study included 326 patients with confirmed SARS-CoV-2 infection evaluated at the Emergency Department of the Umberto I Polyclinic Hospital, Rome, Italy between March 6th and April 30th, 2020. In order to assess xerostomia, olfactory and gustatory dysfunctions secondary to COVID-19, a telephone-based a modified survey obtained from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 for taste and smell disorders and the Fox Questionnaire for dry mouth were administered to 111 patients (34%) after discharge between June 4th and June 12th. RESULTS: Taste dysfunction was the most common reported symptom (59.5%; n = 66), followed by xerostomia (45.9%; n = 51) and olfactory dysfunctions (41.4%; n = 46). The most severe symptom was olfactory dysfunction with a median severity score of 8.5 (range: 5-10). Overall 74.5% (n = 38) of patients with xerostomia, 78.8% (n = 52) of patients with gustatory dysfunctions and 71.1% (n = 33) of patients with olfactory dysfunctions reported that all symptoms appeared before COVID-19 diagnosis. Overall, the majority of patients reported one symptom only (45.9%, n = 51), 37 (33.3%) reported the association of two symptoms, and 23 (20.7%) patients reported the association of three symptoms at the same time. CONCLUSION: Xerostomia, gustatory and olfactory dysfunctions may present as a prodromal or as the sole manifestation of COVID-19. Awareness is fundamental to identify COVID-19 patients at an early stage of the disease and limit the spread of the virus.


Assuntos
Infecções por Coronavirus/epidemiologia , Transtornos do Olfato/virologia , Pneumonia Viral/epidemiologia , Distúrbios do Paladar/virologia , Xerostomia/virologia , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus , Estudos de Coortes , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Transtornos do Olfato/epidemiologia , Pandemias , Prevalência , Estudos Retrospectivos , Índice de Gravidade de Doença , Inquéritos e Questionários , Distúrbios do Paladar/epidemiologia , Xerostomia/epidemiologia
3.
Gerodontology ; 37(4): 317-331, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32965067

RESUMO

BACKGROUND: The proportion of elders is increasing worldwide, and hyposalivation has been associated with the ageing process. Therefore, there has been growing interest in the frequency of hyposalivation in older people since it can cause transient or permanent problems that could affect oral health. OBJECTIVE: To determine the prevalence of hyposalivation in older people (aged ≥ 60 years). METHODS: The review was registered at Prospero - International Prospective Register of Systematic Reviews under number CRD42018106322. The search was performed in six electronic databases (Embase, LILACS, Medline, PubMed, Web of Science and Abstracts in Social Gerodontology) and grey literature (Google Scholar) for articles published up to February 2019. The methodology of selected studies was evaluated using the Meta-Analysis of Statistics Assessment and Review (MAStARI) risk of bias checklist. Meta-analyses were performed using Medcalc and Stata 15. RESULTS: Thirteen studies totalising 3,885 individuals (≥60 years) were included in this systematic review. The meta-analysis showed an overall hyposalivation prevalence of 33.37% (95% confidence interval [CI] 23.90 - 43.57, P < .0001, n = 3,447). The prevalence of hyposalivation for unstimulated and stimulated methods was 33.39% (95% CI 21.08 - 46.96, P < .0001, n = 2,425 individuals) and 30.47% (95% CI 22.53-39.04, P < .0001, n = 1,495 individuals), respectively. Most of the studies were evaluated as low risk of bias. Some study limitations were related to the observational studies potential risk of bias, and different criteria to measure saliva flow rate. CONCLUSION: This study suggests that the overall prevalence of hyposalivation in older people is 33.37%. When considering stimulated methods, the prevalence of hyposalivation was slightly lower (30.47%).


Assuntos
Xerostomia , Idoso , Idoso de 80 Anos ou mais , Humanos , Saúde Bucal , Prevalência , Risco , Xerostomia/epidemiologia
4.
Geriatr Gerontol Int ; 20(10): 917-926, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32830417

RESUMO

AIM: This large epidemiological survey of older people examined oral hypofunction and the relationship between oral hypofunction and frailty. METHODS: Participants were community-dwelling adults aged 65-85 years in Japan. The oral function evaluation included seven items (oral hygiene, oral dryness, occlusal force, tongue-lip motor function, tongue pressure, masticatory function and swallowing function), and oral hypofunction was defined as having abnormalities in at least three of these items. The frailty status was classified into three categories (robust, pre-frail and frail) according to the total Kihon Checklist score. We analyzed 978 subjects with complete data. The relationship between oral function and frailty status was analyzed using multivariate multinomial logistic regression analyses. RESULTS: Approximately 60% of the older adults had oral hypofunction. The multivariate odds ratios (ORs) for a pre-frail or frail status were significantly higher for older people with reduced occlusal force, reduced tongue-lip motor function and deteriorated swallowing function than in those without deterioration of those items. Of the oral function items, swallowing function was most strongly associated with the frailty status, and the ORs (95% confidence interval [CI]) for deteriorated swallowing function in pre-frail and frail patients were 6.4 (3.9-10.8) and 10.2 (5.4-19.1), respectively. Those with oral hypofunction had significantly higher adjusted ORs for pre-frail (OR 1.4, 95% CI 1.1-2.0) and frail (OR 2.1, 95% CI 1.2-3.5) statuses. CONCLUSION: Many community-dwelling older people have reduced oral function or oral hypofunction, which is significantly associated with frailty in older people. Geriatr Gerontol Int 2020; 20: 917-926.


Assuntos
Idoso Fragilizado/estatística & dados numéricos , Saúde Bucal/estatística & dados numéricos , Higiene Bucal/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Força de Mordida , Lista de Checagem , Estudos Transversais , Transtornos de Deglutição/epidemiologia , Feminino , Fragilidade , Avaliação Geriátrica , Humanos , Vida Independente , Japão , Masculino , Mastigação , Razão de Chances , Inquéritos e Questionários , Xerostomia/epidemiologia
5.
Aust Dent J ; 65 Suppl 1: S67-S70, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32583587

RESUMO

BACKGROUND: Little is known of the occurrence of dry mouth among Australians. AIM: To describe the prevalence and associations of xerostomia in a nationally representative sample of Australian adults. METHODS: Dentate persons aged 15+ years were asked 'How often does your mouth feel dry?' (response options 'never', 'occasionally', 'frequently' or 'always'). Those responding 'frequently' or 'always' were classified as xerostomic. RESULTS: The prevalence of xerostomia was 13.2% (95% CI 12.4, 14.0). It ranged from 9.3% (95% CI 7.9, 10.8) among 15-to-34-year-old to 26.5% (95% CI 23.3, 30.0) among those aged 75+ years. Prevalence was higher in the lowest income tertiles (24.5%, 95% CI 22.6, 26.5), lowest SEIFA tertiles (15.7%, 95% CI 14.2, 17.3), those who were dentally uninsured (16.6%, 95% CI 15.4, 17.8) and those with unfavourable dental visiting patterns (18.1%, 95% CI 16.2, 20.1). CONCLUSIONS: More than one in ten Australians experience dry mouth. Among older Australians, this estimate is one in four. With an ageing, medicated population that is increasing in size, xerostomia is a condition that needs to be better understood, recognized and managed by both dental and general health practitioners.


Assuntos
Xerostomia/epidemiologia , Adolescente , Adulto , Idoso , Austrália/epidemiologia , Humanos , Prevalência , Adulto Jovem
6.
Medicine (Baltimore) ; 99(17): e19523, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32332601

RESUMO

To observe the clinical manifestations and salivary secretion of xerostomia patients in submariners who engaged in a three-month deployment. The general conditions and clinical examination of the 136 submariners were evaluated, by which the patients with xerostomia were screened out and their clinical manifestations were recorded. Besides, the flow rate of unstimulated saliva and stimulated saliva was measured and calculated. Subsequently, the related factors of xerostomia were quantitatively classified and statistically analyzed. In all the involved submariners, 42 were diagnosed to have xerostomia by physical examination after they returned from the task, among which 71.4% showed a decrease in unstimulated salivary flow rate and it was significantly correlated with the accompanying symptoms and their general conditions. Therefore, it was concluded that the occurrence of xerostomia could be related to the service life and job responsibilities of the submariners. The main manifestations were the reduction of unstimulated salivary secretion and the accompanying clinical symptoms such as cheilosis and angular cheilitis. Noticeably, the high psychological pressure and harsh living conditions need to be concerned, and further study should place more concentrations on these comprehensive influence factors and preventive actions of xerostomia.


Assuntos
Militares , Salivação/fisiologia , Xerostomia/epidemiologia , Adulto , China/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Saúde do Trabalhador , Índice de Gravidade de Doença , Medicina Submarina , Xerostomia/patologia
7.
Oral Dis ; 26(5): 1020-1031, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32153093

RESUMO

BACKGROUND: The relationship of burning mouth syndrome (BMS) with possible alterations in patients' general health has been subject of study and controversy during the last years. OBJECTIVE: To analyse the general health status of patients with BMS, comparing it with a control group. METHODS: A case-control study was conducted to compare the diseases, medications, blood test alterations, disturbances in general health, oral quality of life, xerostomia, sleep quality and psychological status between a group of 20 patients with BMS and a group of 40 patients who did not suffer from this disease. RESULTS: BMS patients suffered more comorbidities and consumed more medications than controls. More mental, behavioural or neurodevelopmental disorders in BMS patients were found, consuming more drugs for nervous and cardiovascular systems, and alimentary tract and metabolism. Lower levels of iron and higher levels of folic acid were found in BMS patients compared to controls. General health status, oral health impact, sleepiness, psychological status and xerostomia levels were also significantly worsened in BMS patients than in controls. CONCLUSIONS: BMS patients presented a worsened health status over controls suffering more comorbidities, consuming more medications and showing adverse results in all the health variables analysed in this study.


Assuntos
Síndrome da Ardência Bucal , Nível de Saúde , Xerostomia , Síndrome da Ardência Bucal/complicações , Síndrome da Ardência Bucal/epidemiologia , Estudos de Casos e Controles , Humanos , Qualidade de Vida , Xerostomia/epidemiologia
8.
Scand J Rheumatol ; 49(3): 233-238, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32043398

RESUMO

Objective: There has been no previous study comparing the frequency of sicca symptoms and Sjögren's syndrome (SS) in coeliac patients (CPs) and healthy controls (HCs) using a tight screening method. The aim of this study was to compare the frequency of sicca symptoms and SS in HCs and CPs.Method: The study included 80 CPs and 100 HCs. This study was designed as a case-control study with four phases. The frequency of SS in CPs and HCs was defined according to the 2002 American-European Consensus Group (AECG) and 2012 American College of Rheumatology (ACR) classification criteria. The frequency of sicca symptoms and SS was compared between CPs and HCs.Results: Ocular and oral symptoms occurred in 22% and 26% of CPs, respectively, compared to 13% and 10% of HCs, respectively. Proportions with oral symptoms were statistically significantly different between CPs and HCs (p = 0.005), whereas there was no significant difference for ocular symptoms (p = 0.113). According to ACR and AECG criteria, the prevalence of SS was 3.8% and 5.0% in CPs and 3.0% and 2.0% in HCs, respectively.Conclusion: Although oral symptoms were more frequent in CPs than in HCs, the frequency of SS was not different between the groups. The increased frequency of oral symptoms may be related to reasons other than autoimmunity.


Assuntos
Doença Celíaca/epidemiologia , Síndromes do Olho Seco/epidemiologia , Síndrome de Sjogren/epidemiologia , Xerostomia/epidemiologia , Adulto , Anticorpos Antinucleares/imunologia , Estudos de Casos e Controles , Doença Celíaca/imunologia , Síndromes do Olho Seco/imunologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fator Reumatoide/imunologia , Síndrome de Sjogren/imunologia , Xerostomia/imunologia
9.
Acta Odontol Scand ; 78(3): 229-235, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31729277

RESUMO

Objective: The aim was to study prevalence of xerostomia, hyposalivation and quality of life among caries active younger adults.Materials and methods: A questionnaire regarding oral and general health, xerostomia and quality of life was mailed to 134 caries active (CA) and 40 caries inactive (CI) patients, 25-50 years of age (mean age 39.9 ± 6.2 years) treated at a Swedish Public Dental Service clinic, regarding oral and general health, xerostomia and quality of life. Caries data and unstimulated whole salivary flow rates were obtained from dental records.Results: The overall response rate was 69%. Dental records confirmed that CA patients had more decayed teeth over time than CI patients (p < .001). The CA group reported worse oral health (p < .001) and general health (p < .01), more xerostomia (p < .001) and lower salivary flow rate (p < .01) compared to CI patients. Xerostomia was inversely related to unstimulated whole salivary flow rates as well as to oral and general health (p < .01). There were no differences between groups in quality of life.Conclusion: Younger caries active adult patients reported significantly more xerostomia and hyposalivation compared to caries inactive patients. Xerostomia and hyposalivation were inversely related to perceptions of oral and general health, but not to quality of life.


Assuntos
Cárie Dentária/epidemiologia , Saúde Bucal/estatística & dados numéricos , Qualidade de Vida , Taxa Secretória/fisiologia , Xerostomia/epidemiologia , Adulto , Cárie Dentária/etiologia , Cárie Dentária/psicologia , Humanos , Pessoa de Meia-Idade , Prevalência , Estudos Retrospectivos , Saliva/metabolismo , Autorrelato , Suécia , Xerostomia/psicologia
10.
Diabetes Metab Syndr ; 14(1): 11-15, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31809967

RESUMO

BACKGROUND AND OBJECTIVE: Diabetes mellitus (DM) is a chronic multi-systemic metabolic disorder; diabetic patients are more prone to xerostomia and oral health problems than others. There are evidences that nitric oxide (NO) plays an important role in healthy salivary gland function, prevention of insulin resistance and progression of diabetes mellitus. The aim of this study was to compare the salivary NO level between type 2 diabetic (T2DM) patients with and without xerostomia. METHODS: In this case control study, 70 patients with T2DM, which were matched according to age, sex, type of disease control, were enrolled conveniently. The subjects based on abeslang test were allocated to the two groups; 35 patients with xerostomia and 35 patients without xerostomia. Unstimulated whole saliva was collected by spitting method. NO levels was measured by ELISA method using Griess reaction. Data was analyzed using t-test, ANOVA and logistic regression analysis to examine the association of salivary NO and xerostomia. RESULTS: The mean and standard deviation of salivary NO in the diabetic subjects with xerostomia was significantly lower than diabetic subjects without xerostomia (138 ± 94.58 µmol/L vs. 356.61 ± 302.81 µmol/L (P-value = 0.001). In logistic regression analysis, salivary NO level was associated with 0.994 fold decreased risk of xerostomia in diabetic subjects after adjustment for age, gender, FBS and HbA1c. CONCLUSIONS: The present study indicates salivary nitric oxide level was a predictor of xerostomia in diabetic patients. More longitudinal studies are necessary to understand the association of salivary NO level with diabetes-induced xerostomia.


Assuntos
Biomarcadores/metabolismo , Diabetes Mellitus/fisiopatologia , Saúde Bucal , Saliva/metabolismo , Xerostomia/diagnóstico , Adulto , Idoso , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Óxido Nítrico , Prognóstico , Xerostomia/epidemiologia , Xerostomia/metabolismo
11.
Support Care Cancer ; 28(3): 1141-1150, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31203510

RESUMO

PURPOSE: Research investigating swallowing problems (dysphagia) and complications within the oral cavity in non-head and neck cancer patients is limited. The purpose of this study was to determine the prevalence of patient-reported dysphagia and oral complications in all cancer patients and to examine the relationships between cancer types, oral complications and dysphagia. METHODS: A cross-sectional study was conducted at a specialist cancer centre in Australia. Data on patient-reported dysphagia and oral complications were collected using the Vanderbilt Head and Neck Symptom Survey (version 2.0) which was completed by participants in one of three settings: inpatients, ambulatory patients receiving chemotherapy, or ambulatory patients receiving radiotherapy. RESULTS: Data were collected on 239 patients, receiving treatment for 14 cancer types. The proportion of patients who reported dysphagic symptoms were as follows: any dysphagia (54%); dysphagia for liquids (20%); and dysphagia for solids (46%). Significantly more head and neck patients and significantly fewer breast patients reported dysphagia, but there were no differences between other tumour types. Oral symptoms across all cancer types were reported at the following rates: taste changes (62%); xerostomia (56%); voice changes (37%); smell changes (35%); thick mucous (33%); difficulty with teeth/dentures (25%); mouth/throat pain (20%); and trismus (19%). CONCLUSIONS: This is the first time comprehensive data on dysphagia and oral complications across all cancer patients have been collected. We have identified that dysphagic symptoms and oral complications-which have implications for quality of life and function-are common in all cancer patients, not just those with head and neck cancer.


Assuntos
Transtornos de Deglutição/epidemiologia , Neoplasias de Cabeça e Pescoço/patologia , Qualidade de Vida/psicologia , Trismo/epidemiologia , Xerostomia/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor/epidemiologia , Medidas de Resultados Relatados pelo Paciente , Prevalência , Inquéritos e Questionários , Adulto Jovem
12.
Epidemiol Psychiatr Sci ; 29: e49, 2019 Sep 17.
Artigo em Inglês | MEDLINE | ID: mdl-31526409

RESUMO

AIM: Compared with the general population, individuals with schizophrenia have a higher risk of periodontal disease, which can potentially reduce their life expectancy. However, evidence for the early development of periodontal disease in schizophrenia is scant. The current study investigated risk factors for periodontal disease in patients newly diagnosed with schizophrenia. METHODS: We identified a population-based cohort of patients in Taiwan with newly diagnosed schizophrenia who developed periodontal disease within 1 year of their schizophrenia diagnosis. Treatment with antipsychotics and other medications was categorised according to medication type and duration, and the association between medication use and the treated periodontal disease was assessed through logistic regression. RESULTS: Among 3610 patients with newly diagnosed schizophrenia, 2373 (65.7%) had an incidence of treated periodontal disease during the 1-year follow-up. Female sex (adjusted odds ratios [OR] 1.40; 95% confidence interval [CI] 1.20-1.63); young age (adjusted OR 0.99; 95% CI 0.98-0.99); a 2-year history of periodontal disease (adjusted OR 2.45; 95% CI 1.84-3.26); high income level (adjusted OR 2.24; 95% CI 1.64-3.06) and exposure to first-generation (adjusted OR 1.89; 95% CI 1.54-2.32) and secondary-generation (adjusted OR 1.33; 95% CI 1.11-1.58) antipsychotics, anticholinergics (adjusted OR 1.24; 95% CI 1.03-1.50) and antihypertensives (adjusted OR 1.91; 95% CI 1.64-2.23) were independent risk factors for periodontal disease. Hyposalivation - an adverse effect of first-generation antipsychotics (FGAs) (adjusted OR 2.00; 95% CI 1.63-2.45), anticholinergics (adjusted OR 1.27; 95% CI 1.05-1.53) and antihypertensives (adjusted OR 1.90; 95% CI 1.63-2.22) - was associated with increased risk of periodontal disease. Therefore, hypersalivation due to FGA use (adjusted OR 0.72; 95% CI 0.59-0.88) was considered a protective factor. CONCLUSIONS: The current study highlights that early prevention of periodontal disease in individuals with schizophrenia is crucial. Along with paying more attention to the development of periodontal disease, assessing oral health regularly, helping with oral hygiene, and lowering consumption of sugary drinks and tobacco, emphasis should also be given by physicians to reduce the prescription of antipsychotics to the extent possible under efficacious pharmacotherapy for schizophrenia.


Assuntos
Antipsicóticos/uso terapêutico , Doenças Periodontais/epidemiologia , Esquizofrenia/epidemiologia , Xerostomia/epidemiologia , Adulto , Fatores Etários , Anti-Hipertensivos/uso terapêutico , Antagonistas Colinérgicos/uso terapêutico , Estudos de Coortes , Feminino , Gengivite/epidemiologia , Humanos , Renda , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Doenças Periodontais/terapia , Periodontite/epidemiologia , Estudos Retrospectivos , Esquizofrenia/tratamento farmacológico , Fatores Sexuais , Taiwan/epidemiologia , Xerostomia/induzido quimicamente , Adulto Jovem
13.
Oral Dis ; 25(8): 1995-2002, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31407451

RESUMO

OBJECTIVE: The aim of this study was to evaluate the orofacial parameters of systemic sclerosis (SSc) and its related systemic features. SUBJECTS AND METHODS: A descriptive case-control study was performed from November 2015 to October 2016. Ninety-three individuals were included and divided into SSc group (n = 50) and healthy controls (C, n = 43). RESULTS: Systemic sclerosis individuals were mostly women (43/50, 86%), with a mean age of 46 years (±11.6 years). Telangiectasia (42/50, 84%) and reduced mouth opening (35/50, 70%) were the most frequent orofacial findings. The periodontitis frequency was much higher in SSc individuals than in healthy controls (90.7% × 48.83%; p < .001). In addition, SSc individuals presented a distinctive pattern of periodontitis, with low probing pocket depth (2 ± 0.65 mm × 2 ± 0.24; p < .001), higher gingival recession (4 ± 2.13 × 0.14 ± 0,22; p < .001), higher periodontal attachment loss (6 ± 1.34 mm × 2 ± 0.43, p < .001), and lower gingival bleeding index values (7.05 ± 7.25 × 21.57 ± 15.66; p < .001). CONCLUSIONS: Orofacial manifestations were common in SSc and included a unique pattern of periodontal manifestation, characterized by lower gingival bleeding index, higher periodontal attachment loss, and low probing depth.


Assuntos
Hemorragia Gengival/epidemiologia , Perda da Inserção Periodontal , Doenças Periodontais/epidemiologia , Periodontite/epidemiologia , Escleroderma Sistêmico/complicações , Xerostomia/epidemiologia , Adulto , Idoso , Brasil/epidemiologia , Estudos de Casos e Controles , Índice de Placa Dentária , Feminino , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Periodontais/complicações , Doenças Periodontais/diagnóstico , Escleroderma Sistêmico/epidemiologia
14.
J Am Med Dir Assoc ; 20(12): 1654.e1-1654.e9, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31409558

RESUMO

OBJECTIVES: Studies examining the associations between oral health and disability have limited oral health measures. We investigated the association of a range of objectively and subjectively assessed oral health markers with disability and physical function in older age. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analyses were based on the British Regional Heart Study (BRHS) comprising men aged 71 to 92 years (n = 2147) from 24 British towns, and the Health, Aging, and Body Composition (HABC) Study comprising men and women aged 71 to 80 years (n = 3075) from the United States. Assessments included oral health (periodontal disease, tooth count, dry mouth, and self-rated oral health), disability, and physical function (grip strength, gait speed, and chair stand test). RESULTS: In the BRHS, dry mouth, tooth loss, and cumulative oral health problems (≥3 problems) were associated with mobility limitations and problems with activities of daily living and instrumental activities of daily living; these remained significant after adjustment for confounding variables (for ≥3 dry mouth symptoms, odds ratio (OR) 2.68, 95% confidence interval (CI) 1.94-3.69; OR 1.76, 95% CI 1.15-2.69; OR 2.90, 95% CI 2.01, 4.18, respectively). Similar results were observed in the HABC Study. Dry mouth was associated with the slowest gait speed in the BRHS, and the weakest grip strength in the HABC Study (OR 1.75, 95% CI 1.22, 2.50; OR 2.43, 95% CI 1.47-4.01, respectively). CONCLUSIONS AND IMPLICATIONS: Markers of poor oral health, particularly dry mouth, poor self-rated oral health, and the presence of more than 1 oral health problem, were associated with disability and poor physical function in older populations. Prospective investigations of these associations and underlying pathways are needed.


Assuntos
Avaliação da Deficiência , Teste de Esforço , Força da Mão , Saúde Bucal , Velocidade de Caminhada , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Estudos Transversais , Assistência Odontológica/estatística & dados numéricos , Feminino , Humanos , Arcada Edêntula/epidemiologia , Masculino , Limitação da Mobilidade , Bolsa Periodontal/epidemiologia , Perda de Dente/epidemiologia , Reino Unido/epidemiologia , Estados Unidos/epidemiologia , Xerostomia/epidemiologia
15.
J Am Geriatr Soc ; 67(S3): S551-S556, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31403193

RESUMO

OBJECTIVES: Dry mouth is a common condition among older adults that negatively influences oral health, general health, and quality of life. The role of psychosocial factors in oral health conditions and diseases remains largely unknown. We conducted a study to examine the relationship between perceived stress and dry mouth among US older Chinese adults and further investigated the potential moderating role of social support and social strain from different sources in the relationship. DESIGN: Cross-sectional analysis. SETTING: Baseline of the Population Study of Chinese Elderly in Chicago, a community-engaged, population-based longitudinal study of health and well-being among community-dwelling US older Chinese adults. PARTICIPANTS: Individuals 60 years or older (N = 3157). MEASUREMENTS: Perceived stress was measured by the 10-item Chinese Perceived Stress Scale to evaluate the degree to which life situations were perceived as stressful during the preceding month on a 5-point scale, ranging from 0 ("never") to 4 ("very often"). Dry mouth was a binary self-reported outcome variable (1 = "dry mouth"). Social support was measured by the Health and Retirement Study's social support and strain scale from sources including spouse, other family members, and friends with a 3-point response set, ranging from 0 ("hardly ever") to 2 ("often"). Sociodemographics and disease processes were assessed as covariates. We conducted stepwise logistic regressions with interaction terms. RESULTS: Having higher levels of perceived stress was significantly associated with a higher likelihood of reporting dry mouth (odds ratio = 1.03; 95% confidence interval = 1.02-1.04). The effect of perceived stress on dry mouth may vary by levels of family and friend support. CONCLUSION: Perceived stress may influence dry mouth either directly or indirectly. To prevent or reduce dry mouth, in addition to disease processes, interventions need to consider psychosocial factors in dry mouth, especially perceived stress and social support, in this growing population. J Am Geriatr Soc 67:S551-S556, 2019.


Assuntos
Americanos Asiáticos/estatística & dados numéricos , Saúde Bucal/estatística & dados numéricos , Estresse Psicológico/epidemiologia , Xerostomia/epidemiologia , Atividades Cotidianas/psicologia , Idoso , Idoso de 80 Anos ou mais , Americanos Asiáticos/psicologia , Chicago/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência , Qualidade de Vida , Fatores de Risco , Apoio Social , Estresse Psicológico/psicologia , Xerostomia/psicologia
16.
Asian Pac J Cancer Prev ; 20(8): 2463-2470, 2019 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-31450921

RESUMO

Objective: The present study aims to evaluate the accelerated intensity modulated radiotherapy (IMRT) of head and neck (HandN) treatments using physical indices and radiobiological models with its clinical correlation using histogram analysis in radiation therapy (HART). The radiobiological evaluation in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP) indices were compared with acute toxicity. Materials and Methods: A total of twenty patients with stage III and IV of HandN cases treated with accelerated IMRT using 6MV photons were chosen for the study. Using HART software, physical indices of the IMRT plans have been defined by universal plan indices (UPI's) which summarize the various recognized plan indices. The overall quality factor (QF) of a plan was determined by a linear combination of all indices in UPI set. The clinical outcomes in terms of the acute toxicity like dysphagia and xerostomia were compared with NTCP values of the OAR calculated from HART software. Results: The mean QF and the mean Poisson TCP index was found to be 0.993±0.02 and 0.86 ±0.02 respectively. The mean JT Lyman NTCP index for bilateral parotid, constrictors, and larynx were found to be 0.23±0.14, 0.30±0.17 and 0.22±0.15 respectively. The acute toxicities in terms of severity of xerostomia and dysphagia have shown a moderate correlation with NTCP values of bilateral parotids, constrictors, and larynx, respectively. Conclusion: The mean QF based on UPI was found to be close to unity, which correlates with being a better IMRT plan. The present study suggested the existence of a moderate correlation between the calculated NTCP values and their respective severities of the organ at risk (OAR's). Accelerated IMRT with chemotherapy is a clinically feasible option in the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) with encouraging initial tumor response and acceptable acute toxicities.


Assuntos
Quimiorradioterapia/métodos , Transtornos de Deglutição/epidemiologia , Neoplasias de Cabeça e Pescoço/terapia , Planejamento da Radioterapia Assistida por Computador/métodos , Radioterapia de Intensidade Modulada/métodos , Carcinoma de Células Escamosas de Cabeça e Pescoço/terapia , Xerostomia/epidemiologia , Adulto , Idoso , Feminino , Seguimentos , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Incidência , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Dosagem Radioterapêutica , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia
17.
Head Neck ; 41(10): 3594-3603, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31329343

RESUMO

BACKGROUND: Acute and late toxicity after intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) impacts on patient quality of life; yet, very late toxicity data remain scarce. This study assessed dysphagia, xerostomia, and neck fibrosis 3-8 years after IMRT. METHODS: A retrospective analysis using generalized estimated equations was performed on 60 patients with HNC treated with fractionated IMRT between 2000 and 2015 who had a follow-up ≥8 years. Toxicity was scored using LENT-SOMA scales. RESULTS: A trend towards a nonlinear global time effect (P = .05) was noted for dysphagia with a decrease during the 5 years post-treatment and an increase thereafter. A significant decrease in xerostomia (P = .001) and an increase in neck fibrosis (P = .04) was observed until 8 years. CONCLUSIONS: Dysphagia, xerostomia, and neck fibrosis do not appear stable over time and remain highly prevalent in the very late follow-up. Our findings support the need for prospective trials investigating very late toxicity in patients with HNC.


Assuntos
Carcinoma de Células Escamosas/radioterapia , Transtornos de Deglutição/radioterapia , Neoplasias de Cabeça e Pescoço/radioterapia , Pescoço/patologia , Radioterapia de Intensidade Modulada/efeitos adversos , Xerostomia/etiologia , Adulto , Idoso , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Estudos de Coortes , Transtornos de Deglutição/epidemiologia , Transtornos de Deglutição/fisiopatologia , Feminino , Fibrose/epidemiologia , Fibrose/etiologia , Fibrose/fisiopatologia , Seguimentos , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Dosagem Radioterapêutica , Radioterapia de Intensidade Modulada/métodos , Estudos Retrospectivos , Medição de Risco , Fatores de Tempo , Resultado do Tratamento , Xerostomia/epidemiologia , Xerostomia/fisiopatologia
18.
Geriatr Gerontol Int ; 19(8): 792-797, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31267649

RESUMO

AIM: To examine the association between a decrease in the frequency of going out and oral function in independent older adults living in the urban area of Tokyo. METHODS: The participants analyzed were 785 older adults from the "Takashimadaira Study" (344 men and 441 women, age 77.0 ± 4.6 years). This study investigated the following items: decrease in frequency of going out; basic characteristics (sex, age); physical factors, such as oral function (difficulty chewing, difficulty swallowing, dry mouth); body pain; the Japan Science and Technology Agency Index of Competence; physical activities; psychological factors, such as the Geriatric Depression Scale-15 score; and social and environmental factors, such as the presence or absence of participation in organization activities. RESULTS: To investigate the factors associated with a decrease in frequency of going out, logistic regression analysis showed an association with age (OR 1.08, 95% CI 1.03-1.13), difficulty chewing (OR 2.41, 95% CI 1.52-3.83), dry mouth (OR 1.68, 95% CI 1.07-2.64), body pain (OR 1.78, 95% CI 1.14-2.78), Japan Science and Technology Agency Index of Competence scores (OR 0.91, 95% CI 0.84-0.99), physical activities (OR 0.99, 95% CI 0.98-1.00), Geriatric Depression Scale-15 scores (OR 1.13, 95% CI 1.05-1.21) and organization activities (OR 1.94, 95% CI 1.22-3.07). Covariance structural analyses showed that both "difficulty chewing" and "dry mouth" significantly affected "decrease in frequency of going out." In addition, decrease in frequency of going out was significantly affected by " Geriatric Depression Scale-15 scores" through oral function. CONCLUSIONS: The relationship between oral function and decrease in frequency of going out was clarified, after the multifaceted factors were adjusted. Geriatr Gerontol Int 2019; 19: 792-797.


Assuntos
Atividades Cotidianas , Transtornos de Deglutição , Vida Independente/psicologia , Saúde Bucal/estatística & dados numéricos , Isolamento Social , Xerostomia , Idoso , Idoso de 80 Anos ou mais , Correlação de Dados , Transtornos de Deglutição/epidemiologia , Transtornos de Deglutição/psicologia , Comportamento Alimentar , Feminino , Inquéritos Epidemiológicos , Pacientes Domiciliares/psicologia , Pacientes Domiciliares/estatística & dados numéricos , Humanos , Japão/epidemiologia , Assistência de Longa Duração/estatística & dados numéricos , Masculino , População Urbana/estatística & dados numéricos , Xerostomia/epidemiologia , Xerostomia/psicologia
19.
Oral Oncol ; 95: 115-119, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31345378

RESUMO

INTRODUCTION: Even the most modern radiation techniques still result in some degree of toxicity to adjacent normal tissues. Consequently, the radiotherapy treatment in head and neck neoplasms potentially leads to gustatory dysfunction even in cases when the treatment area is outside or adjacent to the oral cavity. In this study we quantitatively and qualitatively assessed gustatory function in patients with head and neck cancers who underwent radiotherapy inside and outside of the oral cavity. METHODS: Fifty-six patients with head and neck cancer responded to a specific questionnaire and had their gustatory function tested before, immediately after, and at 3 and 6 months following radiotherapy treatment. The irradiation field did not include the oral cavity in 29 patients and included it in 27 patients. RESULTS: All patients suffered a severe loss of taste immediately after radiotherapy. The identification of sweet and bitter tastes decreased in both groups, but the sour decrement was exclusive to those who had the oral cavity irradiated. Fourteen percent of patients complained of qualitative changes of taste, namely taste distortions. No impact of xerostomia on the taste measures was apparent. CONCLUSION: We found that patients with head and neck neoplasms submitted to radiotherapy have disturbed taste even when irradiation does not include the oral cavity. This deficit is worse immediately after the end of radiotherapy. Our findings do not support the hypothesis that decreased salivary flow is the major cause for radiation-induced changes in taste function.


Assuntos
Disgeusia/epidemiologia , Neoplasias de Cabeça e Pescoço/radioterapia , Lesões por Radiação/epidemiologia , Percepção Gustatória/efeitos da radiação , Xerostomia/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Fracionamento da Dose de Radiação , Disgeusia/diagnóstico , Disgeusia/etiologia , Feminino , Neoplasias de Cabeça e Pescoço/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Lesões por Radiação/diagnóstico , Lesões por Radiação/etiologia , Índice de Gravidade de Doença , Inquéritos e Questionários/estatística & dados numéricos , Fatores de Tempo , Xerostomia/diagnóstico , Xerostomia/etiologia , Adulto Jovem
20.
Eur J Haematol ; 103(4): 300-306, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31240771

RESUMO

OBJECTIVES: Haematopoietic stem cell transplantation (HSCT) recipients are at risk of side effects within the oral cavity. The purpose of this study was to examine progression of common oral diseases and hyposalivation and their associations with survival in allogeneic HSCT recipients. METHODS: Two hundred and sixty nine adult HSCT recipients treated with HSCT between 2008 and 2016 were included in this study. The associations of caries, decayed, missing, filled teeth (DMFT) index, radiological attachment loss and stimulated salivary flow rate with 6-month survival and the progression of the oral disorders within 2 years were examined. RESULTS: Forty HSCT recipients (14.8%) deceased within 6 months post-HSCT. Among the deceased recipients, hyposalivation and caries were more common pre-HSCT than in recipients who survived over 6 months (P < 0.05). HSCT recipients with hyposalivation pre-HSCT had higher risk of death (HR: 1.90, 95% CI:1.00-3.60; P = 0.044) within 6 months post-HSCT compared with recipients without hyposalivation. Hyposalivation pre-HSCT was associated with a higher DMFT index score (P < 0.05) and a smaller number of teeth (P < 0.005) 24 months post-HSCT in comparison with those without hyposalivation. CONCLUSIONS: Hyposalivation and caries were associated with a lower rate of survival in HSCT recipients. Additionally, hyposalivation predisposed to deterioration of oral health post-HSCT.


Assuntos
Transplante de Células-Tronco Hematopoéticas , Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Xerostomia/epidemiologia , Xerostomia/etiologia , Adulto , Idoso , Feminino , Doença Enxerto-Hospedeiro/diagnóstico , Doença Enxerto-Hospedeiro/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Doenças da Boca/diagnóstico , Prognóstico , Taxa de Sobrevida , Resultado do Tratamento , Xerostomia/diagnóstico , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...