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1.
BMC Womens Health ; 21(1): 235, 2021 06 06.
Artigo em Inglês | MEDLINE | ID: mdl-34092217

RESUMO

BACKGROUND: The basic principle of vaginal laser therapy is the rejuvenation of the affected tissue. Zinc and copper are essential nutritional trace elements and have a key role in connective tissue homeostasis. We aimed to investigate the effect of vaginal, fractional CO2 laser treatment on cervicovaginal lavage (CVL) zinc and copper levels. METHODS: Twenty-nine postmenopausal women with symptoms of vaginal dryness were enrolled in our prospective cohort study. Three treatments with MonaLisa Touch CO2 laser system were performed four weeks apart. At each treatment CVL was collected, Vaginal Health Index (VHI) was obtained, and Visual Analog Scale (VAS) for vaginal dryness was assigned by patients. Zinc and copper concentrations were measured with optical emission spectrometry before each treatment and six weeks after the 3rd treatment. RESULTS: The VHI scores significantly improved after each laser treatment (mean ± SD VHI score, 13.03 ± 4.49 before vs. 15.55 ± 4.35 after the 1st, 17.79 ± 4.57 after the 2nd and 19.38 ± 4.39 after the 3rd treatment, P < 0.01). Similarly, VAS scores reflected improvement (mean ± SD VAS score 6.59 ± 2.86 before vs. 4.17 ± 2.86 after the 1st, 2.45 ± 2.43 after the 2nd and 1.41 ± 1.94 after the 3rd treatment, P < 0.01). CVL zinc levels were significantly higher compared to copper levels (0.06 ± 0.04 vs. 0.006 ± 0.006 mg/L, P < 0.01) at baseline. While copper levels remained the same through treatments, the CVL zinc level was significantly higher after the second laser treatment compared to the baseline. CONCLUSIONS: Fractional CO2 laser treatment of the vagina impacts CVL zinc and copper levels differently. While CVL copper levels were not different after each laser treatment, zinc levels were significantly higher after the second treatment before returning to baseline values.


Assuntos
Dióxido de Carbono , Cobre , Feminino , Humanos , Estudos Prospectivos , Irrigação Terapêutica , Resultado do Tratamento , Vagina/cirurgia , Zinco/uso terapêutico
2.
Vopr Pitan ; 90(2): 26-39, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34019346

RESUMO

The problem of increasing immunity has become especially relevant in the conditions of the rapid spread of the new coronavirus infection SARS-CoV-2. Nowadays it has been proven that a deficiency of certain micronutrients in the diet can disrupt chemical, structural and regulatory processes in the organism, which negatively affects, first of all, the state of immune system. Zinc is one of the most significant essential trace elements affecting immunological resistance. The aim of the study was to substantiate the need of including zinc-containing products and diet supplements in the diet of the population during the SARS-CoV-2 pandemic on the basis of the study of pathogenetic mechanisms of various disorders of the immunological status under zinc deficit. Material and methods. This review analyzes the data from scientific electronic libraries CyberLeninka, eLIBRARY.RU, the Google Scholar databases and bibliographic medical databases MEDLINE and PubMed-NCBI. Results and discussion. During the SARS-CoV-2 pandemic, adequate zinc supply is especially important, due to its antiviral, immunomodulatory and antiapoptotic effects. This element also regulates the severity of the cytokine response, exhibits antibacterial properties and helps to compensate for chronic comorbid diseases, which plays a particularly significant role in preventing severe SARS-CoV-2 and recurrent respiratory diseases. Prevention and correction of zinc deficiency is considered as one of the important measures during the SARS-CoV-2 pandemic, aimed at increasing antiviral and general immunity, reducing the systemic inflammatory response and correcting hormonal and metabolic status. Conclusion. The pathogenetically substantiated inclusion of zinc-containing foods and supplements in the diet will enhance the immunity of the population during the SARSCoV- 2 pandemic.


Assuntos
COVID-19 , Pandemias , SARS-CoV-2/imunologia , Zinco/uso terapêutico , COVID-19/dietoterapia , COVID-19/epidemiologia , COVID-19/imunologia , Humanos
4.
Clin Dermatol ; 39(1): 107-117, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33972037

RESUMO

The coronavirus disease 2019 pandemic has had a profound effect on our lives and careers; this presentation explores some of the lessons we have learned from it and others that it may yet teach us. Socioeconomic effects have been profound, not all of them favorable. Travel and meeting activities, as well as many other activities, have been severely restricted. Social unrest has become intense, and it may have questionable political consequences, as the United States is undergoing a contested election result.


Assuntos
Vacinas contra COVID-19 , COVID-19/prevenção & controle , COVID-19/terapia , Controle de Doenças Transmissíveis/métodos , Monofosfato de Adenosina/análogos & derivados , Monofosfato de Adenosina/uso terapêutico , Corticosteroides/uso terapêutico , Alanina/análogos & derivados , Alanina/uso terapêutico , Antibacterianos/uso terapêutico , Antimaláricos/uso terapêutico , Antivirais/uso terapêutico , Azitromicina/uso terapêutico , COVID-19/complicações , COVID-19/mortalidade , Vacinas contra COVID-19/efeitos adversos , Quimioterapia Combinada , Humanos , Hidroxicloroquina/uso terapêutico , SARS-CoV-2 , Estatística como Assunto , Zinco/uso terapêutico
5.
J Pak Med Assoc ; 71(3): 921-924, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34057949

RESUMO

OBJECTIVE: To assess mothers' knowledge about the quantity of oral rehydration salt and zinc in the management of diarrhoea. METHODS: The cross-sectional study was conducted from May to August 2019 at The Children's Hospital, Lahore, Pakistan, and comprised mothers accompanying children aged <5 years admitted with diarrhoea complaints. Data was collected regarding demographics and mothers' awareness of signs of dehydration in diarrhoea, familiarity with the term oral rehydration salt, its correct preparation and administration and zinc supplementation. Data was analysed using SPSS 20. RESULTS: Of the 334 mothers interviewed, 154(46%) were able to identify the signs of dehydration. Maternal awareness regarding use of oral rehydration salt and zinc in diarrhoea were significantly associated with maternal education and socioeconomic status (p<0.05). CONCLUSIONS: There is a need to generate awareness among mothers about the use of oral rehydration salt and zinc in diarrhoea.


Assuntos
Mães , Zinco , Criança , Estudos Transversais , Diarreia/epidemiologia , Diarreia/terapia , Eletrólitos , Feminino , Humanos , Paquistão , Centros de Atenção Terciária , Zinco/uso terapêutico
6.
Clin Nutr ESPEN ; 43: 9-15, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34024569

RESUMO

Respiratory Viruses infections (RVI) such as rhinovirus, coronavirus, influenza virus, and adenovirus affect the respiratory and the immune systems. The role of nutrition in the respiratory and immune systems has been studied in some studies, and its importance is undeniable. In addition, one of the key findings in this disease is high inflammation that affects almost all patients. This systematic narrative review aims to answer the question, "Can an anti-inflammatory diet be effective in preventing or treating viral respiratory diseases?" A systematic review search was used for the articles extraction. All studies published in English from 1999 to 2020 investigating dietary inflammatory conditions and RVI were included. Food items with anti-inflammatory properties were selected based on the definition of the dietary inflammatory index (DII). We used Google Scholar, Pub Med, Scopus, Web of Science, Springer, Science Direct, Directory of Open Access Journals, Elsevier, Taylor and Francis, ProQuest, EBSCO, MEDLINE, and SciELO databases for extracting articles. Keywords were restricted by DII. Based on DII, food items/nutrients are involved in inflammation, some of which have anti-inflammatory and some inflammatory properties. Some foods/nutrients, in addition to their anti-inflammatory properties, have antioxidant, antiviral, and immune-enhancing properties. Considering the immune system's involvement, increased inflammation, and involvement of the pulmonary system in RVI and the remarkable role of the anti-inflammatory foods for counteracting them, it is recommended to use a predominantly anti-inflammatory diet along with prevention/control and treatment protocols. An anti-inflammatory diet (based on DII) includes turmeric, ginger, garlic, onions, saffron, dietary vitamin C, vitamin D, zinc, and omega-3 are recommended to reduce infection symptoms and duration.


Assuntos
Anti-Inflamatórios/uso terapêutico , Ácidos Graxos Ômega-3/uso terapêutico , Micronutrientes/uso terapêutico , Extratos Vegetais/uso terapêutico , Infecções Respiratórias/dietoterapia , Viroses/dietoterapia , Vírus , Adenoviridae , Anti-Inflamatórios/farmacologia , Coronavirus , Infecções por Coronavirus/complicações , Infecções por Coronavirus/virologia , Crocus , Dieta/classificação , Ácidos Graxos Ômega-3/farmacologia , Humanos , Inflamação/dietoterapia , Inflamação/etiologia , Micronutrientes/farmacologia , Nutrientes/farmacologia , Nutrientes/uso terapêutico , Estado Nutricional , Orthomyxoviridae , Extratos Vegetais/farmacologia , Infecções Respiratórias/complicações , Infecções Respiratórias/prevenção & controle , Infecções Respiratórias/virologia , Rhinovirus , Viroses/complicações , Viroses/prevenção & controle , Viroses/virologia , Vitaminas/farmacologia , Vitaminas/uso terapêutico , Zinco/farmacologia , Zinco/uso terapêutico , Zingiberaceae
7.
Clin Nutr ESPEN ; 43: 39-48, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34024545

RESUMO

BACKGROUND: The enormous health impact of the COVID-19 pandemic has refocused attention on measures to optimize immune function and vaccine response. Dietary deficiencies of micronutrients can weaken adaptive immunity. The aim of this review was to examine links between micronutrients, immune function and COVID-19 infection, with a focus on nutritional risks in subgroups of the Swiss population. METHODS: Scoping review on the associations between selected micronutrients (vitamins D and C, iron, selenium, zinc, and n-3 PUFAs) and immunity, with particular reference to the Swiss population. These nutrients were chosen because previous EFSA reviews have concluded they play a key role in immunity. RESULTS: The review discusses the available knowledge on links between sufficient nutrient status, optimal immune function, and prevention of respiratory tract infections. Because of the rapid spread of the COVID-19 pandemic, controlled intervention studies of micronutrients in the context of COVID-19 infection are now underway, but evidence is not yet available to draw conclusions. The anti-inflammatory properties of n-3 PUFAs are well established. In Switzerland, several subgroups of the population are at clear risk of nutrient deficiencies; e.g., older adults, multiple comorbidities, obesity, pregnancy, and institutionalized. Low intakes of n-3 PUFA are present in a large proportion of the population. CONCLUSION: There are clear and strong relationships between micronutrient and n-3 PUFA status and immune function, and subgroups of the Swiss population are at risk for deficient intakes. Therefore, during the COVID-19 pandemic, as a complement to a healthy and balanced diet, it may be prudent to consider supplementation with a combination of moderate doses of Vitamins C and D, as well as of Se, Zn and n-3 PUFA, in risk groups.


Assuntos
COVID-19/tratamento farmacológico , Suplementos Nutricionais , Ácidos Graxos Ômega-3/uso terapêutico , Fatores Imunológicos/uso terapêutico , Oligoelementos/uso terapêutico , Vitaminas/uso terapêutico , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/uso terapêutico , Ácido Ascórbico/farmacologia , Ácido Ascórbico/uso terapêutico , COVID-19/imunologia , Comorbidade , Ácidos Graxos Ômega-3/farmacologia , Feminino , Humanos , Fatores Imunológicos/farmacologia , Masculino , Micronutrientes/farmacologia , Micronutrientes/uso terapêutico , Estado Nutricional , Pandemias , Gravidez , SARS-CoV-2 , Selênio/farmacologia , Selênio/uso terapêutico , Suíça , Oligoelementos/farmacologia , Vitamina D/farmacologia , Vitamina D/uso terapêutico , Vitaminas/farmacologia , Zinco/farmacologia , Zinco/uso terapêutico
8.
Biomed Pharmacother ; 139: 111626, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33894625

RESUMO

In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Alternatively, pterostilbene-zinc combination might be also considered without using a nano-carrier. We recommend conducting prompt clinical trials to assess the potential of the suggested combinations as a monotherapy for mild COVID-19 with a potential to prevent its progression to moderate-severe disease for which we recommend their trial as an adjuvant therapy. Furthermore, the suggested combinations might also possess a pharmacotherapeutic potential that exceeds COVID-19 to various inflammatory, immunologic, and oncologic diseases.


Assuntos
Antivirais/uso terapêutico , COVID-19/tratamento farmacológico , Sistemas de Liberação de Medicamentos , Nanopartículas , Resveratrol/uso terapêutico , Estilbenos/uso terapêutico , Zinco/uso terapêutico , Humanos
9.
Medicina (Kaunas) ; 57(4)2021 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-33920654

RESUMO

Background and Objectives: Burning mouth syndrome (BMS) is an enigmatic, idiopathic, chronic, often painful clinical entity, where patients experience oral burning without clear clinical changes on the oral mucosa. There are yet to be well established standardized and validated definitions, diagnostic criteria or classifications for burning mouth syndrome. The aim of this study is to determine whether vitamin B complex and zinc supplements or 0.02% topical capsaicin rinse, can help alleviate BMS pain/burning levels. The objectives: (1) Gather data before and after treatment with vitamin B complex and zinc supplements (2) After the vitamin B complex and zinc protocol gather data before and after treatment with 0.02% topical capsaicin rinse (3) Data analysis and assessment for both treatment methods. Materials and Methods: 89 patients took part in the vitamin B and zinc supplement treatment regimen, out of those 20 patients took part in the capsaicin rinse treatment regimen. Before and after each treatment pain/burning levels were determined using the Visual analogue scale, salivary flow was also determined. Results: Both treatment methods showed statistically significant data in reducing pain/burning levels. There were no statistically significant changes in the salivary flow after any treatment. Conclusion: vitamin B and zinc supplement therapy and topical capsaicin rinse therapy can be an effective way to decrease pain/burning sensation levels in patients with BMS. More research should be conducted to determine the benefit of either vitamin B and zinc supplement therapy or topical capsaicin rinse therapy, so that BMS patients have treatment options, that have as few side-effects as possible.


Assuntos
Síndrome da Ardência Bucal , Complexo Vitamínico B , Síndrome da Ardência Bucal/tratamento farmacológico , Capsaicina/uso terapêutico , Humanos , Dor , Complexo Vitamínico B/uso terapêutico , Zinco/uso terapêutico
10.
Int J Mol Sci ; 22(4)2021 Feb 16.
Artigo em Inglês | MEDLINE | ID: mdl-33669456

RESUMO

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19), is a worldwide pandemic, as declared by the World Health Organization (WHO). It is a respiratory virus that infects people of all ages. Although it may present with mild to no symptoms in most patients, those who are older, immunocompromised, or with multiple comorbidities may present with severe and life-threatening infections. Throughout history, nutraceuticals, such as a variety of phytochemicals from medicinal plants and dietary supplements, have been used as adjunct therapies for many disease conditions, including viral infections. Appropriate use of these adjunct therapies with antiviral proprieties may be beneficial in the treatment and/or prophylaxis of COVID-19. In this review, we provide a comprehensive summary of nutraceuticals, such as vitamins C, D, E, zinc, melatonin, and other phytochemicals and function foods. These nutraceuticals may have potential therapeutic efficacies in fighting the threat of the SARS-CoV-2/COVID-19 pandemic.


Assuntos
COVID-19/tratamento farmacológico , Suplementos Nutricionais , Melatonina/uso terapêutico , Vitaminas/uso terapêutico , Zinco/uso terapêutico , Animais , Antivirais/farmacologia , Antivirais/uso terapêutico , Ácido Ascórbico/farmacologia , Ácido Ascórbico/uso terapêutico , Suplementos Nutricionais/análise , Alimento Funcional/análise , Humanos , Melatonina/farmacologia , SARS-CoV-2/efeitos dos fármacos , Vitamina D/farmacologia , Vitamina D/uso terapêutico , Vitamina E/farmacologia , Vitamina E/uso terapêutico , Vitaminas/farmacologia , Zinco/farmacologia
11.
PLoS One ; 16(3): e0246265, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33661932

RESUMO

Medicinal uses and applications of metals and their complexes are of increasing clinical and commercial importance. The ligation behavior of quercetin (Q), which is a flavonoid, and its Zn (II) (Q/Zn) complex were studied and characterized based on elemental analysis, molar conductance, Fourier-transform infrared (FTIR) spectra, electronic spectra, proton nuclear magnetic resonance (1H-NMR), thermogravimetric analysis, and transmission electron microscopy (TEM). FTIR spectral data revealed that Q acts as a bidentate ligand (chelating ligand) through carbonyl C(4) = O oxygen and phenolic C(3)-OH oxygen in conjugation with Zn. Electronic, FTIR, and 1H-NMR spectral data revealed that the Q/Zn complex has a distorted octahedral geometry, with the following chemical formula: [Zn(Q)(NO3)(H2O)2].5H2O. Diabetes was induced by streptozotocin (STZ) injection. A total of 70 male albino rats were divided into seven groups: control, diabetic untreated group and diabetic groups treated with either MSCs and/or Q and/or Q/Zn or their combination. Serum insulin, glucose, C-peptide, glycosylated hemoglobin, lipid profile, and enzymatic and non-enzymatic antioxidant levels were determined. Pancreatic and lung histology and TEM for pancreatic tissues in addition to gene expression of both SOD and CAT in pulmonary tissues were evaluated. MSCs in combination with Q/Zn therapy exhibited potent protective effects against STZ induced hyperglycemia and suppressed oxidative stress, genotoxicity, glycometabolic disturbances, and structural alterations. Engrafted MSCs were found inside pancreatic tissue at the end of the experiment. In conclusion, Q/Zn with MSC therapy produced a synergistic effect against oxidative stress and genotoxicity and can be considered potential ameliorative therapy against diabetes with pulmonary dysfunction, which may benefit against COVID-19.


Assuntos
Diabetes Mellitus Experimental/terapia , Hipoglicemiantes/uso terapêutico , Transplante de Células-Tronco Mesenquimais , Quercetina/uso terapêutico , Zinco/uso terapêutico , Animais , Glicemia/análise , Glicemia/metabolismo , Peptídeo C/sangue , Peptídeo C/metabolismo , Células Cultivadas , Complexos de Coordenação/química , Complexos de Coordenação/uso terapêutico , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/metabolismo , Diabetes Mellitus Experimental/patologia , Hemoglobina A Glicada/análise , Hemoglobina A Glicada/metabolismo , Hiperglicemia/sangue , Hiperglicemia/metabolismo , Hiperglicemia/patologia , Hiperglicemia/terapia , Hipoglicemiantes/química , Insulina/sangue , Insulina/metabolismo , Pulmão/efeitos dos fármacos , Pulmão/metabolismo , Pulmão/patologia , Masculino , Estresse Oxidativo/efeitos dos fármacos , Quercetina/análogos & derivados , Ratos , Zinco/química
12.
J Med Virol ; 93(7): 4326-4333, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33710631

RESUMO

Several studies have demonstrated an association between individual zinc status and viral respiratory infections; however, evidence regarding COVID-19 is still missing or insufficient. This study aimed to evaluate the correlation between the prevalence of zinc deficiency and COVID-19 cases and deaths per million population in the Asian and European countries. The COVID-19 data from two different time points, that is, May 30 and June 30, 2020 for the Asian population and May 15 and June 15, 2020 for the European population, were analyzed to determine the correlation with the estimated zinc deficiency for these two continents. The prevalence of zinc deficiency was about two times higher in the Asian population (mean 17.5%) than in the European population (mean 8.9%). A significant positive correlation (p < .05) was observed between the prevalence of zinc deficiency and COVID-19 cases at both time periods for the Asian population. However, the correlation between zinc deficiency prevalence and COVID-19 deaths was not significant in the Asian population. In contrast, a significant but negative correlation (p < .05 for all cases) was observed for zinc deficiency with both COVID-19 cases and deaths per million population at both time periods in the European countries. Considering the direct antiviral properties of zinc, it can be suggested that zinc supplementation may be beneficial for most of the population, especially older people and those who are at risk of COVID-19 infections. In conclusion, there is not enough evidence on the association between individual zinc status and COVID-19 infections and mortality. Therefore, cohort studies and randomized controlled trials are required to test this hypothesis.


Assuntos
COVID-19/epidemiologia , SARS-CoV-2/efeitos dos fármacos , Zinco/deficiência , Antivirais/uso terapêutico , Ásia/epidemiologia , COVID-19/dietoterapia , COVID-19/mortalidade , Suplementos Nutricionais , Europa (Continente)/epidemiologia , Humanos , Prevalência , Estudos Retrospectivos , Zinco/sangue , Zinco/uso terapêutico
13.
JAMA Netw Open ; 4(2): e210369, 2021 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-33576820

RESUMO

Importance: There is limited evidence regarding early treatment of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to mitigate symptom progression. Objective: To examine whether high-dose zinc and/or high-dose ascorbic acid reduce the severity or duration of symptoms compared with usual care among ambulatory patients with SARS-CoV-2 infection. Design, Setting, and Participants: This multicenter, single health system randomized clinical factorial open-label trial enrolled 214 adult patients with a diagnosis of SARS-CoV-2 infection confirmed with a polymerase chain reaction assay who received outpatient care in sites in Ohio and Florida. The trial was conducted from April 27, 2020, to October 14, 2020. Intervention: Patients were randomized in a 1:1:1:1 allocation ratio to receive either 10 days of zinc gluconate (50 mg), ascorbic acid (8000 mg), both agents, or standard of care. Outcomes: The primary end point was the number of days required to reach a 50% reduction in symptoms, including severity of fever, cough, shortness of breath, and fatigue (rated on a 4-point scale for each symptom). Secondary end points included days required to reach a total symptom severity score of 0, cumulative severity score at day 5, hospitalizations, deaths, adjunctive prescribed medications, and adverse effects of the study supplements. Results: A total of 214 patients were randomized, with a mean (SD) age of 45.2 (14.6) years and 132 (61.7%) women. The study was stopped for a low conditional power for benefit with no significant difference among the 4 groups for the primary end point. Patients who received usual care without supplementation achieved a 50% reduction in symptoms at a mean (SD) of 6.7 (4.4) days compared with 5.5 (3.7) days for the ascorbic acid group, 5.9 (4.9) days for the zinc gluconate group, and 5.5 (3.4) days for the group receiving both (overall P = .45). There was no significant difference in secondary outcomes among the treatment groups. Conclusions and Relevance: In this randomized clinical trial of ambulatory patients diagnosed with SARS-CoV-2 infection, treatment with high-dose zinc gluconate, ascorbic acid, or a combination of the 2 supplements did not significantly decrease the duration of symptoms compared with standard of care. Trial Registration: ClinicalTrials.gov Identifier: NCT04342728.


Assuntos
Ácido Ascórbico/uso terapêutico , COVID-19/tratamento farmacológico , Suplementos Nutricionais , Zinco/uso terapêutico , Adulto , Assistência Ambulatorial , Antioxidantes/uso terapêutico , COVID-19/complicações , Tosse/tratamento farmacológico , Tosse/etiologia , Dispneia/tratamento farmacológico , Dispneia/etiologia , Fadiga/tratamento farmacológico , Fadiga/etiologia , Feminino , Febre/tratamento farmacológico , Febre/etiologia , Gluconatos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , SARS-CoV-2 , Índice de Gravidade de Doença , Padrão de Cuidado , Oligoelementos/uso terapêutico , Resultado do Tratamento
14.
J Med Virol ; 93(5): 3176-3183, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33590901

RESUMO

This trial compared the rate and time of viral clearance in subjects receiving a combination of nitazoxanide, ribavirin, and ivermectin plus Zinc versus those receiving supportive treatment. This non-randomized controlled trial included 62 patients on the triple combination treatment versus 51 age- and sex-matched patients on routine supportive treatment. all of them confirmed cases by positive reverse-transcription polymerase chain reaction of a nasopharyngeal swab. Trial results showed that the clearance rates were 0% and 58.1% on the 7th day and 13.7% and 73.1% on the 15th day in the supportive treatment and combined antiviral groups, respectively. The cumulative clearance rates on the 15th day are 13.7% and 88.7% in the supportive treatment and combined antiviral groups, respectively. This trial concluded by stating that the combined use of nitazoxanide, ribavirin, and ivermectin plus zinc supplement effectively cleared the SARS-COV2 from the nasopharynx in a shorter time than symptomatic therapy.


Assuntos
COVID-19/tratamento farmacológico , Ivermectina/uso terapêutico , Nitrocompostos/uso terapêutico , Ribavirina/uso terapêutico , SARS-CoV-2 , Tiazóis/uso terapêutico , Zinco/uso terapêutico , Adulto , Antimetabólitos/administração & dosagem , Antimetabólitos/uso terapêutico , Antiparasitários/administração & dosagem , Antiparasitários/uso terapêutico , Feminino , Humanos , Ivermectina/administração & dosagem , Masculino , Nitrocompostos/administração & dosagem , Ribavirina/administração & dosagem , Tiazóis/administração & dosagem , Oligoelementos/administração & dosagem , Oligoelementos/uso terapêutico , Zinco/administração & dosagem
15.
J Med Virol ; 93(5): 3261-3267, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33629384

RESUMO

Zinc inhibits replication of the SARS-CoV virus. We aimed to evaluate the safety, feasibility, and biological effect of administering high-dose intravenous zinc (HDIVZn) to patients with COVID-19. We performed a Phase IIa double-blind, randomized controlled trial to compare HDIVZn to placebo in hospitalized patients with COVID-19. We administered trial treatment per day for a maximum of 7 days until either death or hospital discharge. We measured zinc concentration at baseline and during treatment and observed patients for any significant side effects. For eligible patients, we randomized and administered treatment to 33 adult participants to either HDIVZn (n = 15) or placebo (n = 18). We observed no serious adverse events throughout the study for a total of 94 HDIVZn administrations. However, three participants in the HDIVZn group reported infusion site irritation. Mean serum zinc on Day 1 in the placebo, and the HDIVZn group was 6.9 ± 1.1 and 7.7 ± 1.6 µmol/l, respectively, consistent with zinc deficiency. HDIVZn, but not placebo, increased serum zinc levels above the deficiency cutoff of 10.7 µmol/l (p < .001) on Day 6. Our study did not reach its target enrollment because stringent public health measures markedly reduced patient hospitalizations. Hospitalized COVID-19 patients demonstrated zinc deficiency. This can be corrected with HDIVZn. Such treatment appears safe, feasible, and only associated with minimal peripheral infusion site irritation. This pilot study justifies further investigation of this treatment in COVID-19 patients.


Assuntos
COVID-19/tratamento farmacológico , SARS-CoV-2 , Zinco/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Relação Dose-Resposta a Droga , Método Duplo-Cego , Estudos de Viabilidade , Feminino , Humanos , Injeções Intravenosas , Pacientes Internados , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Projetos Piloto , Respiração Artificial , Zinco/administração & dosagem
16.
Ital J Pediatr ; 47(1): 32, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33588905

RESUMO

BACKGROUND: The role of the immune system and inflammatory response in the pathogenesis of the severe manifestations of coronavirus disease 2019 (COVID-19) is well known. Currently, different therapies active on the immune system are used for the management of COVID-19. The involvement of the immune system also opens the opportunity for the use of nutritional supplements with antimicrobial and immunomodulatory activity. MAIN ASPECTS: Nutritional supplements with antimicrobial and immunomodulatory activity are promising therapeutic adjuvants for the treatment of COVID-19, and also for the prevention of viral spreading. In particular, the role of vitamin D, probiotics, lactoferrin, and zinc is of significant clinical interest, although there are only a few data on their use in COVID-19 patients. Their molecular actions, together with the results of studies performed on other respiratory infections, strongly suggest their potential utility in COVID-19. This article discusses the main properties of these nutritional supplements and their potential applicability in the prevention and treatment of COVID-19. CONCLUSION: The supplementation with vitamin D, probiotics, lactoferrin and zinc could have a role both in preventing SARS-CoV-2 infection and in mitigating the clinical course in infected patients, contributing in the prevention of immune-mediated organ damage.


Assuntos
COVID-19/tratamento farmacológico , COVID-19/imunologia , Suplementos Nutricionais , Humanos , Lactoferrina/uso terapêutico , Pandemias , Probióticos/uso terapêutico , SARS-CoV-2 , Vitamina D/uso terapêutico , Zinco/uso terapêutico
17.
ACS Appl Mater Interfaces ; 13(4): 5782-5794, 2021 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-33464812

RESUMO

Peri-implantitis is a typical pathological condition characterized by the destructive inflammation in the soft tissue and the progressive loss of supporting bones. As the current effective treatments and preventive measures are inconsistent and unpredictable, the use of biomaterials as carriers of bioactive ion coatings is a promising approach. However, the translation from lab to large-scale production and clinical applications is difficult due to a technology barrier. Determining the effective dosage of each ion to achieve an in vivo application of the in vitro screening is challenging. Here, we selected zinc and strontium ions to provide multiple effects on antibacterial activity and osteogenesis. The optimal coating with effective release concentrations of the two ions was obtained after the two-step screening from in vitro testing. The results showed that this type of in vivo bioactive ion usage leads to an enhanced osseointegration during the immediate implantation in a periodontitis-affected environment and prevents soft tissue inflammation and bone resorption in an inflammatory environment. The new biologically active ion screening method could verify the effectiveness of this clinical translation and its potential for large-scale production and could determine the effective dosage of each ion for a specific application.


Assuntos
Antibacterianos/uso terapêutico , Implantes Dentários , Peri-Implantite/prevenção & controle , Estrôncio/uso terapêutico , Zinco/uso terapêutico , Animais , Células Cultivadas , Materiais Revestidos Biocompatíveis/uso terapêutico , Implantes Dentários/microbiologia , Cães , Humanos , Osseointegração/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Peri-Implantite/microbiologia , Ratos Sprague-Dawley , Estomatite/microbiologia , Estomatite/prevenção & controle
18.
Int J Med Sci ; 18(2): 314-324, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33390800

RESUMO

The coronavirus disease 2019 (COVID-19) pandemic is the largest health crisis ever faced worldwide. It has resulted in great health and economic costs because no effective treatment is currently available. Since infected persons vary in presentation from healthy asymptomatic mild symptoms to those who need intensive care support and eventually succumb to the disease, this illness is considered to depend primarily on individual immunity. Demographic distribution and disease severity in several regions of the world vary; therefore, it is believed that natural inherent immunity provided through dietary sources and traditional medicines could play an important role in infection prevention and disease progression. People can boost their immunity to prevent them from infection after COVID-19 exposure and can reduce their inflammatory reactions to protect their organ deterioration in case suffering from the disease. Some drugs with in-situ immunomodulatory and anti-inflammatory activity are also identified as adjunctive therapy in the COVID-19 era. This review discusses the importance of COVID-19 interactions with immune cells and inflammatory cells; and further emphasizes the possible pathways related with traditional herbs, medications and nutritional products. We believe that such pathophysiological pathway approach treatment is rational and important for future development of new therapeutic agents for prevention or cure of COVID-19 infection.


Assuntos
COVID-19/tratamento farmacológico , Interações Hospedeiro-Patógeno , Medicina Tradicional , COVID-19/prevenção & controle , COVID-19/virologia , Quimioterapia Combinada , Humanos , Imunomodulação , Terapia de Alvo Molecular , Fitoterapia , Extratos Vegetais/uso terapêutico , SARS-CoV-2/fisiologia , Vitaminas/uso terapêutico , Zinco/uso terapêutico
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