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1.
Homeopathy ; 2019 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-31319421

RESUMO

INTRODUCTION: In homeopathic philosophy, vital force is a non-material substrate that is responsible for maintaining the body's sensations and functions and where homeopathic medicines act. In genetics, the body's vital functions are controlled by biochemical information, which is contained in the cell genome and consists of a protein encoding portion (exome) and another that regulates this encoding scheme (epigenome). Both the philosophical vital force and the genome present properties of complex and dynamic self-organisation systems. AIMS: This study aimed to explore and develop a philosophical-scientific correlation between vitalism and genetics according to the complexity paradigm. RESULTS: Vital principle and genome present inseparable composition among distinct existing components that influence one another and form a network of connections that create complex and dynamic self-organisation behaviour. Described in both models, 'vortex' indicates the existence of a force coming from within the system that is externalised as an emergent, information-transmitting phenomenon. Supporting this correlation, some experimental studies show that homeopathic medicines act on the genome by modulating gene expression. CONCLUSIONS: In line with the similarity of existing characteristics and properties, the genome may be considered as hypothetical biological substrate of organic vital force.

2.
Homeopathy ; 108(2): 139-148, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30759480

RESUMO

INTRODUCTION: In addition to the four pillars of homeopathy, vitalism and the miasmatic theory are often used to explain the health-disease process. According to Hahnemann's concepts, homeopathic miasms are the main obstacle to the cure of chronic diseases, with psora being the fundamental cause of all forms of diseases. According to modern genetics, the disease-promoting epigenetic alterations are the fundamental cause of the manifestation of chronic diseases. OBJECTIVE: This article develops a philosophical-scientific correlation between chronic miasms and disease-promoting epigenetic modifications, aiming to justify the isopathic use of auto-sarcode of an individual's DNA as homeopathic medicine. RESULTS: Based on the study of homeopathic doctrine and epigenetics, a conceptual and functional correlation is observed between homeopathic chronic miasms and disease-promoting epigenetic modifications. Additionally, several experimental studies suggest that homeopathy's mechanism of action may be by modulating gene expression. CONCLUSIONS: By the philosophical-scientific correlations described, it is inferred that disease-promoting epigenetic alterations are the biological representation of the chronic miasms, suggesting the isopathic use of auto-sarcode of DNA as homeopathic therapeutic modulator of gene expression for the management of chronic diseases.

7.
Rev Assoc Med Bras (1992) ; 63(2): 100-108, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-28355369

RESUMO

The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients. Describing existing lines of research and a specific method for the therapeutic use of the rebound effect of modern drugs (http://www.newhomeopathicmedicines.com), we hope to minimize prejudices related to the homeopathy and contribute to a broadening of the healing art.


Assuntos
Homeopatia , Farmacopeias Homeopáticas como Assunto , Terapias Complementares , Humanos
8.
Eur J Obstet Gynecol Reprod Biol ; 211: 48-55, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28187404

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). RESULTS: The EAPP global score (VAS: range 0 to 50) decreased by 12.82 (P<0.001) in the group treated with potentized estrogen from baseline to week 24. Group that used potentized estrogen also exhibited partial score (VAS: range 0 to 10) reduction in three EAPP modalities: dysmenorrhea (3.28; P<0.001), non-cyclic pelvic pain (2.71; P=0.009), and cyclic bowel pain (3.40; P<0.001). Placebo group did not show any significant changes in EAPP global or partial scores. In addition, the potentized estrogen group showed significant improvement in three of eight SF-36 domains (bodily pain, vitality and mental health) and depression symptoms (BDI). Placebo group showed no significant improvement in this regard. These results demonstrate superiority of potentized estrogen over placebo. Few adverse events were associated with potentized estrogen. CONCLUSIONS: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02427386.


Assuntos
Endometriose/complicações , Estrogênios/administração & dosagem , Dor Pélvica/terapia , Adolescente , Adulto , Método Duplo-Cego , Estrogênios/uso terapêutico , Feminino , Homeopatia , Humanos , Pessoa de Meia-Idade , Dor Pélvica/etiologia , Resultado do Tratamento , Adulto Jovem
9.
Rev. homeopatia (Säo Paulo) ; 80(1/2,supl): 27-51, 2017.
Artigo em Português | LILACS | ID: biblio-973264

RESUMO

INTRODUÇÃO: O modelo homeopático de tratamento utiliza o ‘princípio dos semelhantes’ como método terapêutico, administrando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curantur), com o intuito de despertar uma reação secundária e curativa do organismo contra os seus próprios distúrbios. Essa reação secundária (vital, homeostática ou paradoxal) do organismo está embasada no ‘efeito rebote’ dos fármacos modernos, evento adverso observado após a descontinuação de diversas classes de drogas que utilizam o ‘princípio dos contrários’ (contraria contrariis curantur) como método terapêutico...


INTRODUCTION: Homeopathy employs the so-called ‘principle of similars’as therapeutic method, which consists in administering medicines thatcause certain symptoms in healthy individuals to treat similar symptomsin sick individuals (similia similibus curantur) to arouse a secondaryand healing reaction by the body against its own disorders. Thissecondary (vital, homeostatic or paradoxical) reaction of the body isbased on the ‘rebound effect’ of modern drugs, a type of adverseevent that occurs following discontinuation of several classes of drugsprescribed according to the ‘principle of contraries’ (contraria contrariiscurantur)....


Assuntos
Humanos , Homeopatia , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Rebote , Lei dos Semelhantes , Farmacologia
11.
Rev. homeopatia (Säo Paulo) ; 80(3/4): 16-35, 2017.
Artigo em Inglês | LILACS | ID: biblio-973268

RESUMO

Background: Used as complementary to, alternating or integrated with mainstream medicine, the population’s demand for non-conventional therapies has substantially increased in the past decades, requiring from doctors knowledge on the basic notions of such therapeutics to orient their patients regarding treatments different to the ones they usually prescribe. Among them, homeopathy and acupuncture are considered medical specialties in Brazil for various decades. Aim: To describe the current state of medical education in non-conventional therapies (homeopathy and acupuncture) around the world. Methods: We updated data resulting from studies and reviews published until 2013 through a review of more recent studies included in database PubMed. Results: In all countries the teaching of non-conventional therapies is considered a relevant topic for the training of doctors as a function of the increasing interest of the population in their use, with a broad range of approaches targeting undergraduate and graduate students, medical residents and doctors from other medical specialties. Conclusions: The Brazilian medical schools must provide undergraduate and graduate students and medical residents accurate knowledge on the theoretical assumptions and clinical-therapeutic approaches proper to homeopathy and acupuncture, among other non-conventional therapies.


Assuntos
Terapias Complementares , Educação Médica/tendências , Acupuntura , Homeopatia
12.
Rev. homeopatia (Säo Paulo) ; 80(3/4): 36-81, 2017.
Artigo em Inglês | LILACS | ID: biblio-973269

RESUMO

BACKGROUND: Homeopathy employs the so-called ‘principle of similars’ as therapeutic method - which consists in administering medicines that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur) - to induce a secondary and healing reaction by the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). AIM: The present review sought to scientifically substantiate the homeopathic healing principle vis-à-vis experimental and clinical pharmacology through a systematic study of the rebound effect of modern drugs or paradoxical reaction of the body. METHODS: Employing as reference studies and revisions on the subject published since 1998, we updated the data adding recent studies included in database PubMed. RESULTS: The rebound effect occurs after discontinuation of several classes of drugs with action contrary to the symptoms of diseases, exacerbating them to levels above the ones before treatment. [...]. Following the homeopathic premises, modern drugs might also be used according to the principle oftherapeutic similitude, thus employing the rebound effect (paradoxical reaction) with curative intent. CONCLUSIONS: Evidenced by hundreds of studies that attest to the similarityof concepts and manifestations, the rebound effect of modern drugs scientifically substantiates the principle of homeopathic cure. Although the rebound phenomenon is anadverse event studied by modern pharmacology, it is not known by health care professionals, thus depriving doctors of knowledge indispensable for safe management of drugs.


Assuntos
Humanos , Homeopatia , Ação Farmacodinâmica do Medicamento Homeopático , Efeito Rebote , Lei dos Semelhantes , Farmacologia
13.
Rev. homeopatia (Säo Paulo) ; 80(3/4): 104-120, 2017. tab
Artigo em Inglês | LILACS | ID: biblio-973272

RESUMO

BACKGROUND: Among the non-conventional assumptions of homeopathy, the use of medicines in high dilutions (HD) is a cause for objections and skepticism among the scientific community, trained within the dose-dependency paradigm of classic pharmacology. Research aiming at evidencing the effects of homeopathic HD has resource to several experimental models (in vitro, plants and animals). AIM: To describe the results of studies with high methodological quality that demonstrated positiveeffects of homeopathic HD on plants. METHODS: Taking reviews published until 2015 as reference source, we updated the information through addition of data from recent studies included in database PubMed. RESULTS: From 167 experimental studies analyzed, 48 met the minimum criteria of methodological quality, from which 29 detected specific effects of homeopathic high dilutions on plants through comparison to adequate controls. CONCLUSIONS: Despite the substandard methodological quality ofmost experiments, studies with systematic use of negative controls and reproducibility demonstrated significant indisputable effects of homeopathic HD on plants.


Assuntos
Homeopatia , Plantas , Agricultura , Altas Potências , Patologia Vegetal , Metodologia
14.
Rev. homeopatia (Säo Paulo) ; 80(3/4): 134-135, 2017.
Artigo em Inglês | LILACS | ID: biblio-973275

RESUMO

OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebocontrolled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score ≥ 5 on a visual analogue scale (VAS: range 0 to 10 points) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). RESULTS: The EAPP global score (VAS: range 0 to 50 points) decreased by 12.82 (p< 0.001) in the group treated with potentized estrogen from baseline to week 24. Group that used potentized estrogen also exhibited partial score (VAS: range 0 to 10 points) reduction in three EAPP modalities: dysmenorrhea (3.28; p< 0.001), non-cyclic pelvic pain (2.71; p= 0.009), and cyclic bowel pain (3.40; p< 0.001). Placebo group did not show any significant changes in EAPP global or partial scores. [...] CONCLUSIONS: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. Trial registration: ClinicalTrials.gov Identifier: https://clinicaltrials.gov/show/NCT02427386.


Assuntos
Feminino , Humanos , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Homeopatia , Medicamento Homeopático , Efeito Rebote , Endometriose , Estrogênios/uso terapêutico , Dor Pélvica/terapia
15.
Rev. homeopatia (São Paulo) ; 80(1/2): i-iii, 2017.
Artigo em Português | HomeoIndex - Homeopatia | ID: hom-11967

RESUMO

Ao discorrermos sobre a homeopatia em diversas situações, frequentemente notamos que as pessoas reagem com manifestações de desconfiança, questionando sua comprovação científica e a validade terapêutica do método. Proclamada em todos os meios, de forma indistinta e reiterada, a falácia ou pós-verdade de que “não existem evidências científicas em homeopatia” acaba se incorporando ao inconsciente da coletividade, servindo como estratégia para aumentar preconceitos e radicalizar posicionamentos contrários a essa prática médica bissecular. Fruto da desinformação ou da negação dos estudos que fundamentam o modelo homeopático em vários campos da ciência, esse preconceito se retroalimenta de tempos em tempos com matérias e artigos depreciativos publicados nas mídias e redes sociais, as quais, raramente, divulgam os trabalhos com resultados favoráveis à homeopatia. Com o intuito de esclarecer a classe médica e a sociedade em geral, buscando desmistificar posturas dogmáticas culturalmente arraigadas, a Câmara Técnica de Homeopatia do Conselho Regional de Medicina do Estado de São Paulo (CREMESP) elaborou o presente Dossiê Especial, “Evidências Científicas em Homeopatia”, contando com o apoio da Associação Médica Homeopática Brasileira (AMHB) e da Associação Paulista de Homeopatia (APH) em sua divulgação na Revista de Homeopatia da APH.


Assuntos
Medicina Baseada em Evidências , Homeopatia , Fundamentos da Homeopatia
16.
Rev. homeopatia (São Paulo) ; 80(1/2): 18-39, 2017.
Artigo em Português | HomeoIndex - Homeopatia | ID: hom-11969

RESUMO

Introdução: Empregadas de forma alternada, complementar ou integrada ao modelo biomédicovigente, a demanda da população por terapêuticas não convencionais vem aumentadosubstancialmente nas últimas décadas, exigindo dos médicos noções básicas dessas diversasterapias, a fim de que possam orientar seus pacientes em tratamentos diferentes dos que estãoacostumados a prescrever. Dentre essas, a homeopatia e a acupuntura são consideradasespecialidades médicas há décadas no Brasil. Objetivo: Descrever o panorama mundial daeducação médica em terapêuticas não convencionais (homeopatia e acupuntura). Métodos:Empregando como fonte de referência os estudos e revisões sobre o tema que publicamos até2013, atualizamos os dados acrescentando pesquisas recentes citadas na base de dadosPubMed. Resultados: Em todos os países, destaca-se a importância do ensino dessas abordagensterapêuticas na educação médica, em vista do interesse crescente da população em suautilização e, consequentemente, da classe médica em seu aprendizado, com propostas diversasdirecionadas aos estudantes, residentes, pós-graduandos e médicos de outras especialidades.Conclusões: Por esses motivos, as escolas de medicina brasileiras têm a responsabilidade de propiciar aos estudantes, residentes e pós-graduandos o conhecimento das evidências científicas, dos pressupostos teóricos e das abordagens clínico-terapêuticas empregadas pela homeopatia e pela acupuntura, dentre outras. (AU)


Introduction: Used as complementary to, alternating or integrated with mainstream medicine,the population’s demand for non-conventional therapies has substantially increased in the pastdecades, requiring from doctors knowledge on the basic notions of such therapeutics to orienttheir patients regarding treatments different to the ones they usually prescribe. Among them,homeopathy and acupuncture are considered medical specialties in Brazil for various decades.Aim: To describe the current state of medical education on non-conventional therapies(homeopathy and acupuncture) in the world. Methods: We updated data resulting from studiesand reviews published until 2013 through a review of more recent studies included in databasePubMed. Results: In all countries the teaching of non-conventional therapies is considered arelevant topic in the training of doctors as a function of the increasing interest of the public intheir use, with a broad range of approaches targeting undergraduate and graduate students,medical residents and doctors engaged in other medical specialties. Conclusions: The Brazilianmedical schools must provide undergraduate and graduate students and medical residentsaccurate knowledge on the theoretical assumptions and clinical-therapeutic approaches properto homeopathy and acupuncture, among other non-conventional therapies. (AU)


Assuntos
Humanos , Terapias Complementares , Educação Médica/tendências , Acupuntura , Homeopatia
17.
Rev. homeopatia (São Paulo) ; 80(1/2): 40-88, 2017.
Artigo em Português | HomeoIndex - Homeopatia | ID: hom-11970

RESUMO

Introdução: O modelo homeopático de tratamento utiliza o ‘princípio dos semelhantes’ como método terapêutico, administrando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curantur), com o intuito de despertar uma reação secundária e curativa do organismo contra os seus próprios distúrbios. Essa reação secundária (vital, homeostática ou paradoxal) do organismo está embasada no ‘efeito rebote’ dos fármacos modernos, evento adverso observado após a descontinuação de diversas classes de drogas que utilizam o ‘princípio dos contrários’ (contraria contrariis curantur) como métodoterapêutico. Objetivo: Esta revisão visa fundamentar cientificamente o princípio de cura homeopático perante a farmacologia clínica e experimental, através do estudo sistemático do efeito rebote dos fármacos modernos ou reação paradoxal do organismo. Métodos: Empregando como fonte de referência os estudos e revisões sobre o tema que vimos publicando desde 1998, atualizamos os dados acrescentando pesquisas recentes citadasna base de dados PubMed. Resultados: O efeito rebote ocorre após a descontinuação de inúmeras classes de fármacos com ação terapêutica contrária aos sintomas das doenças, exacerbando-os a níveis superiores aos anteriores do tratamento. Independente da doença, da droga, da dose e da duração do tratamento, o fenômeno rebote se manifesta numa pequena proporção de indivíduos suscetíveis. Seguindo as premissas homeopáticas, osfármacos modernos também podem ser utilizados segundo o princípio da similitude terapêutica, empregando o efeito rebote (reação paradoxal) de forma curativa Conclusões: [...] Embora o fenômeno rebote seja um evento adversoestudado pela farmacologia moderna, ele não é conhecido pelos profissionais da saúde, privando a classe médica de um saber indispensável ao manejo seguro dos fármacos. (AU)


Introduction: Homeopathy employs the so-called ‘principle of similars’ as therapeutic method, which consists in administering medicines that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur)to arouse a secondary and healing reaction by the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). Aim: The present review sought to scientifically substantiate the homeopathic healing principle vis-à-vis experimental and clinical pharmacology through a systematic study of the rebound effect of modern drugs or paradoxical reaction of the body. Methods: Employing as reference the studies and revisions on the subject that we have published since 1998, we updated the data adding recent studies cited in database PubMed. Results: The rebound effect occurs after discontinuation of several classes of drugs with contrary action to the symptoms of diseases, exacerbating them to levels above the ones present before treatment. Regardless of disease, drug, dose and duration of treatment, the rebound phenomenon manifests in a small proportion of susceptible individuals.[...] Conclusions: Evidenced in hundreds of studies that attest to the similarity of concepts and manifestations, the rebound effect of modern drugs scientifically substantiates the principle of homeopathic cure. Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is not known by healthcare professionals, thus depriving doctors of knowledge indispensable for a safe management of drugs. (AU)


Assuntos
Humanos , Homeopatia , Efeito Rebote , Lei dos Semelhantes , Ação Farmacodinâmica do Medicamento Homeopático , Farmacologia
18.
Rev. homeopatia (São Paulo) ; 80(1/2): 113-132, 2017. tab
Artigo em Português | HomeoIndex - Homeopatia | ID: hom-11973

RESUMO

Introdução: Dentre as premissas não convencionais do modelo homeopático, o emprego de doses ultradiluídas de medicamentos desperta questionamentos e ceticismo na classe científica, acostumada ao paradigma dose-dependente da farmacologia clássica. Para evidenciar o efeito das ultradiluições homeopáticas em seres vivos, pesquisas são realizadas em diversos modelos experimentais (in vitro, em plantas e em animais). Objetivo: Descrever os estudos de melhor qualidade metodológica que confirmaram o efeito positivo das ultradiluições homeopáticas em plantas. Métodos: Utilizando como fontes de referência as revisões sobre o tema publicadas até 2015, atualizamos os dados adicionando estudos recentes citados na base de dados PubMed. Resultados: Dentre 167 estudos experimentais analisados nas principais revisões, 48 atingiram os critérios mínimos de qualidade metodológica e 29identificaram os efeitos específicos das ultradiluições homeopáticas em plantas, empregando controles adequados. Conclusões: Apesar da qualidade metodológica insatisfatória da maioria dos experimentos, estudos com controle negativo sistemático e reprodutibilidade reportaram efeitos significativos e incontestáveis das ultradiluições homeopáticas em plantas. (AU)


Introduction: Among the non-conventional grounds of homeopathy, the use of medicines in high dilutions is a cause for objections and skepticism among the scientific community, trained within the dose-dependency paradigm of classicpharmacology. Research aiming at evidencing the effects of homeopathic high dilutions has resource to several experimental models (in vitro, in plants and in animals). Aim: To describe the results of studies with high methodological quality that demonstrated positive effects of homeopathic high dilutions on plants. Methods: Taking reviews published until 2015 as reference source, we updated the information through the addition of data in recent studies included in database PubMed. Results: From 167 experimental studies analyzed in the main reviews, 48 met the minimum criteria of methodological quality, from which 29 detected specific effects of homeopathic high dilutions on plants through comparison with adequate controls. Conclusions: Despite the substandard methodological quality of most experiments, studies with systematic use of negative controls and reproducibility demonstrated significant undeniable effectsof homeopathic high dilutions on plants. (AU)


Assuntos
Agricultura , Homeopatia , Altas Potências , Patologia Vegetal , Metodologia
19.
Rev. homeopatia (São Paulo) ; 80(1/2): 148-163, 2017. graf, tab
Artigo em Português | HomeoIndex - Homeopatia | ID: hom-11975

RESUMO

Objetivo: Avaliar a eficácia e a segurança do estrogênio potencializado em comparação com o placebo no tratamento homeopático da dor pélvica associada à endometriose (DPAE). Desenho do estudo: Ensaio randomizado, duplo-cego e placebocontrolado de 24 semanas de duração, que incluiu 50 mulheres com idade entre 18-45 anos de idade, diagnóstico de endometriose infiltrativa profunda com base em ressonância magnética nuclear ou ultrassonografia transvaginal após preparo intestinal e escore ≥ 5 na escala analógica visual (EAV: intervalo de 0 a 10 pontos) para DPAE. Estrogênio potencializado (12cH, 18cH e 24cH) ou placebo foi administrado 2 vezes ao dia por via oral. A medida de desfecho primário foi a mudança na severidade da DPAE com base no escore global e parcial (EAV) entre as semanas 0-24, determinado pela diferença entre a pontuação média de 5 modalidades de dor pélvica crônica (dismenorreia, dispareunia de profundidade, dor pélvica acíclica, dor intestinal cíclica e/ou dor urinária cíclica). Os desfechos secundários foram: diferença nos escores médios para qualidade de vida (SF-36), sintomas de depressão (Inventário de Depressão de Beck, IDB) e sintomas de ansiedade (Inventário de Ansiedade de Beck, IAB). [...]O grupo placebo não mostrou qualquer melhora significativa nesses desfechos secundários. Esses resultados demonstraram a superioridade do estrogênio potencializado em comparação ao placebo. Alguns efeitos adversos foram associados com o estrogênio dinamizado. Conclusões: Estrogênio potencializado (12cH, 18cH e 24cH) na dose de 3 gotas 2 vezes ao dia durante 24 semanas foi significativamente mais eficaz que o placebo na redução da dor pélvica associada à endometriose.Registro do estudo: ClinicalTrials.gov Identificador: NCT02427386. (AU)


Objective: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebocontrolled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score ≥ 5 on a visual analogue scale (VAS: range 0 to 10 points) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). [...] Placebo group did not show any significant changes in EAPP global or partial scores. In addition, the potentized estrogen group showed significant improvement in three of eight SF-36 domains (bodily pain, vitality and mental health) and depression symptoms (BDI). Placebo group showed no significant improvement in this regard. These results demonstrate superiority of potentized estrogen over placebo. Few adverse events were associated with potentized estrogen. Conclusions: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. Trial registration: ClinicalTrials.gov Identifier: NCT02427386. (AU)fier: NCT02427386. (AU)


Assuntos
Humanos , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Homeopatia , Medicamento Homeopático , Efeito Rebote , Endometriose , Estrogênios/uso terapêutico , Dor Pélvica/terapia
20.
Rev. homeopatia (São Paulo) ; 80(3/4): i-iii, 2017.
Artigo em Inglês | HomeoIndex - Homeopatia | ID: hom-12031

RESUMO

Upon discussing homeopathy in various settings, we often find that people react with mistrust, and raise doubts on its scientific grounds and therapeutic validity. Widely disseminated in the mass media, in an indistinct and reiterated manner, the fallacy – or post-truth – asserting “there are no scientific evidence for homeopathy” is incorporated into the collective subconscious, thus serving as strategy to increase prejudice and radicalize postures against this bicentennial medical approach. (AU)


Assuntos
Homeopatia , Medicina Baseada em Evidências , Fundamentos da Homeopatia
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