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1.
Invest. educ. enferm ; 37(3): [E011], 15 Octubre 2019. Tab 1, Tab 2, Tab 3, Fig 1, Fig 2, Fig 3
Artículo en Inglés | LILACS, COLNAL | ID: biblio-1023504

RESUMEN

Objective. This research sought to analyze the predictive effect of personal (personality traits), social (social support and social stigma) and community factors (characteristic of the neighborhood and exposure to consumption) on the transition of drug use in young adults. Methods. Case and control study. The cases were 70 individuals from 18 to 34 years of age who had already transitioned into illicit drug use and the controls were 210 legal drug usuers (tobacco or alcohol) in the same age range who had not had the transition. A data file was applied along with seven instruments that measured the transition and consumption variables. Results. Marihuana was the illicit drug of highest transition. It was shown that greater personality traits of neuroticism, extraversion, and openness to the experience meant higher probability of drug use transition; while greater personality traits of agreeableness and conscience meant lower probability for the transition. The characteristics of the neighborhood environment and exposure to the opportunity of consumption increase the probability of the drug use transition. Social support and social stigma influenced negatively upon the drug use transition. Conclusion. Personality traits, neighborhood characteristics, exposure to drug use, social support, and the social stigma of drug use are factors that intervene in the transition from legal to illicit drug use.


Objetivo. Analizar el efecto predictivo de factores personales (rasgos de personalidad), sociales (apoyo social y estigma social) y comunitarios (características del barrio y exposición al consumo) sobre la transición del consumo de drogas en jóvenes. Métodos. Estudio de casos y controles. Los casos fueron 70 personas de 18 a 34 años que habían transitado al consumo de drogas ilícitas y los controles fueron 210 personas de la misma edad consumidores de alguna droga lícita (tabaco o alcohol) que no han tenido transición. Se aplicó una cédula de datos y siete instrumentos que midieron las variables de transición y consumo. Resultados. La droga ilegal de mayor transición fue la marihuana. Se mostró que a mayores rasgos de personalidad de neuroticismo, extraversión y apertura a la experiencia fue más alta la probabilidad de la transición del consumo de drogas, por el contrario, a mayores rasgos de personalidad amabilidad y conciencia fue menor fue la probabilidad para la transición. Las características del entorno de barrio y la exposición a la oportunidad de consumo incrementan la probabilidad de la transición del consumo de drogas. El apoyo social y el estigma social influyeron negativamente en la transición del consumo de drogas. Conclusión. Los rasgos de personalidad, las características del barrio, la exposición al consumo de drogas, el apoyo social y el estigma social del consumo de drogas son factores que intervienen en la transición del consumo de drogas legales a ilegales.


Objetivo. Analisar o efeito preditivo de fatores pessoais (características de personalidade), sociais (apoio social e estigma social) e comunitários (características do bairro e exposição ao consumo) sobre a transição do consumo de drogas em jovens. Métodos. Estudo de casos e controles. Os casos foram 70 pessoas de 18 a 34 anos que haviam transitado ao consumo de drogas ilícitas e os controles foram 210 pessoas da mesma idade consumidores de alguma droga lícita (tabaco ou álcool) que não hão tido transição. Se aplicou uma cédula de dados e sete instrumentos que mediram as variáveis de transição e consumo. Resultados. A droga ilegal de maior transição foi a maconha. Se mostrou que as de maiores características de personalidade de neuroticismo, extroversão e apertura à experiência foi mais alta a probabilidade da transição do consumo de drogas; enquanto que a maiores traços de personalidade amabilidade e consciência foi menor foi a probabilidade para a transição. As características do entorno de bairro e a exposição à oportunidade de consumo incrementam a probabilidade da transição do consumo de drogas. O apoio social e a estigma social influenciaram negativamente na transição do consumo de drogas. Conclusão. Os traços de personalidade, as características do bairro, a exposição ao consumo de drogas, o apoio social e a estigma social do consumo de drogas são fatores que intervém na transição do consumo de drogas legais a ilegais.


Asunto(s)
Humanos , Personalidad , Apoyo Social , Drogas Ilícitas , Estudios de Casos y Controles , Características de la Residencia , Encuestas y Cuestionarios , Factores de Riesgo , Adulto Joven , Consumidores de Drogas , Estigma Social
2.
Prensa méd. argent ; 105(7): 399-404, agosto 2019. tab
Artículo en Inglés | LILACS, BINACIS | ID: biblio-1022114

RESUMEN

PCOS is known now as an endocrine, metabolic, and chronic inflamatory disorder, with hyperandrogenemia, insulin resistance and obesity being the key factors that influence the expression and symptoms of the condition. Objective: To assess the level of alpha fetoprotein in PCOS women. Patients and method: A case control study conducted at Al-Elwyia. Teaching hospital when 200 women were enrolled in the study and divided into two groups: case group (100) patients with PCOS and control healthy group (100). The patient with PCOS women was diagnosed according to Roterdam criteria. Results: A total of 200 respondents and divided into 2 groups. The mean age of them (27.7 ± 2.3) years, highly significant association (P <0,001) were found between the age group especially (21-30) years in PCOS patients moreover highly significant association were found between the obese patient in PCOS than that in normal group (P<0.001). Betatrophin levels were significantly highly increases in patients than that in control group (P<0.001). Conclusion: the serum betatrophin level was significantly increased in patients with polycystic syndrome (AU)


Asunto(s)
Humanos , Femenino , Adulto , Síndrome del Ovario Poliquístico , alfa-Fetoproteínas , Estudios de Casos y Controles , Hiperandrogenismo , Selección de Paciente
3.
Prensa méd. argent ; 105(7): 410-415, agosto 2019. tab, graf
Artículo en Inglés | LILACS, BINACIS | ID: biblio-1022189

RESUMEN

Bachkgrond: Anemia is a very important nutritional disorder in the world, it has multiple etiologies and pregnancy is associated with a deficit in the intake of iron and physiological changes of pregnancy. Aim of the study: To assess the prevalence of anemia in pregnant Iraqi women. Patients and method: A cross-sectional study carried at Al-Elwyia maternity teaching hospital in the period from the 1st of Jan. 2018 to the end of October 2018, in which 1000 pregnant women were enrolled in the study and divided into 2 groups: case group (n=652) and control group (n=348) according to the level of Hb. Results: The mean age of the case group was (27.8±7.1) years old and (26.1±2.3) years for the control group. The anemia was found in (6521000) patients and Iron deficiency anemia is the main type of anemia (80.2%) while (19.8%) was another type of anemia. Poor diet (65%) is the common cause of anemia were found commonly in the 3rd trimester (50.2%). Conclusion: The prevalence of anemia was 65.2% in the current study (AU)


Asunto(s)
Humanos , Femenino , Embarazo , Adulto , Tercer Trimestre del Embarazo , Hemoglobinas/deficiencia , Embarazo , Estudios de Casos y Controles , Declaración de Helsinki , Anemia/diagnóstico
4.
Int. j. morphol ; 37(2): 724-729, June 2019. tab, graf
Artículo en Español | LILACS | ID: biblio-1002284

RESUMEN

La influencia de la función respiratoria en el desarrollo de estructuras orofaciales y postura craneocervical ha sido ampliamente discutida. El objetivo del estudio fue comparar valores cefalométricos de la región craneocervical e hioidea en sujetos con respiración nasal y oral. Se incluyeron sujetos de entre 18 y 27 años, de ambos sexos, donde 20 presentaban diagnóstico de respiración oral y 20 no presentaban esta alteración; mediante telerradiografía lateral de cabeza y cuello se realizó análisis cefalométrico craneocervical de Rocabado y aplicación de la técnica de Penning, obteniendo medidas craneocervicales e hioideas, dimensión anterior nasofaríngea y curvatura cervical. Para el análisis estadístico se utilizó la prueba de normalidad Shapiro-Wilk y la prueba T para muestras independientes, considerando un valor de p <0,05 para obtener diferencias significativas; en aquellos parámetros en donde no se presentó distribución normal se aplicó la prueba U de Mann-Whitney. No se encontraron diferencias significativas entre los grupos de estudio y los valores cefalométricos analizados, a excepción de la distancia entre la base del hueso occipital y el arco posterior del atlas (p=0,03). Existen limitadas diferencias cefalométricas entre sujetos con respiración oral y respiración nasal, no asociándose el espacio aéreo nasofaríngeo con las modalidades de respiración estudiadas. Deben ser consideradas condiciones de morfología facial o mandibular, para determinar más adecuadamente la influencia de los parámetros cefalométricos en el diagnóstico del modo respiratorio en estudios futuros.


The influence of respiratory function on the development of orofacial structures and craniocervical posture has been widely discussed. The objective of the study was to compare cephalometric values of the craniocervical and hyoid region in subjects with nasal and oral respiration. Subjects between 18 and 27 years of age, of both sexes, were included, where 20 presented oral breathing diagnosis and 20 did not present this alteration; using lateral telerradiography of the head and neck, craniocervical cephalometric analysis was performed of Rocabado and Penning technique was applied, obtaining craniocervical and hyoid measurements, anterior nasopharyngeal dimension and cervical curvature. For the statistical analysis we used the Shapiro-Wilk normality test and the T test for independent samples, considering a value of p <0.05 to obtain significant differences; in those parameters where no normal distribution was presented, the MannWhitney U test was applied. No significant differences were found between the study groups and the cephalometric values ??analyzed, except for the distance between the base of the occipital bone and the posterior arch of the atlas (p=0.03). There are limited cephalometric differences between subjects with oral breathing and nasal breathing, with no association of the nasopharyngeal air space with the breathing modalities studied. Conditions of facial or mandibular morphology should be considered in order to determine more adequately the influence of cephalometric parameters in the diagnosis of the respiratory mode in future studies.


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Adulto Joven , Cráneo/anatomía & histología , Vértebras Cervicales/anatomía & histología , Hueso Hioides/anatomía & histología , Respiración por la Boca , Postura , Cráneo/diagnóstico por imagen , Estudios de Casos y Controles , Obstrucción Nasal , Vértebras Cervicales/diagnóstico por imagen , Nasofaringe/anatomía & histología , Cefalometría , Telerradiología , Estudio Observacional , Hueso Hioides/diagnóstico por imagen
5.
Rev. bras. cir. plást ; 34(1): 31-37, jan.-mar. 2019. ilus, tab
Artículo en Portugués | LILACS | ID: biblio-994539

RESUMEN

Introdução: Lipoaspiração associada a dermolipectomias é o procedimento cirúrgico mais comumente realizado em cirurgia plástica. Apesar de ser considerada uma cirurgia extremamente segura, algumas considerações devem ser levantadas a respeito dos possíveis efeitos metabólicos que essas cirurgias possam causar. O desenvolvimento da técnica tumescente de lipoaspiração permitiu a remoção de grande quantidade de gordura de modo mais seguro. O objetivo é comparar as variações do perfil lipídico em pós-operatório precoce e tardio de pacientes submetidos à lipoaspiração e dermolipectomias. Métodos: Entre outubro de 2006 e junho de 2012, 40 pacientes do sexo feminino candidatas a cirurgias que envolviam lipoaspiração e dermolipectomias foram acompanhadas prospectivamente e o perfil lipídico foi analisado por meio de exames no pré-operatório e no pós-operatório. As cirurgias realizadas foram: mamoplastia + lipoaspiração, abdominoplastia + lipoaspiração e lipoabdominoplastia + mamoplastia. Resultados: Das 40 pacientes que foram acompanhadas no estudo, 20 pacientes do sexo feminino foram selecionadas (após a aplicação dos critérios de exclusão). Em consonância com nosso estudo, Cazes, em 1996, demonstrou que após 12 meses de pós-operatório de lipoabdominoplastia não houve alteração do perfil lipídico das pacientes. Conclusão: Após análise pré- e pós-operatória de 20 pacientes, observamos que não há alterações estatísticas significantes em relação ao perfil lipídico com tendência de equilíbrio das aferições em um ano em patamares próximos aos observados no pré-operatório.


Introduction: Liposuction associated with dermolipectomies is the most commonly performed surgical procedure in plastic surgery. Although regarded as an extremely safe surgery, some considerations must be taken on the possible metabolic effects of these surgeries. The development of the tumescent technique in liposuction allowed the safer removal of large amounts of fat. The objective is to compare lipid profile variations in the early and late postoperative period in patients undergoing liposuction and dermolipectomies. Methods: Between October 2006 and June 2012, 40 female patients who were candidates for surgeries involving liposuction and dermolipectomies were prospectively followed, and the lipid profile was analyzed through preoperative and postoperative examinations. The surgeries performed were mammoplasty + liposuction, abdominoplasty + liposuction, and lipoabdominoplasty + mammoplasty. Results: Of the 40 female patients who were followed, 20 were selected (after applying the exclusion criteria). In agreement with our study, in 1996, Cazes showed that there were no changes in the lipid profile of patients 12 months after lipoabdominoplasty. Conclusion: After a preoperative and postoperative analysis of 20 patients, it was observed that there were no statistically significant changes in the lipid profile and that the measurements after 1 year were close to those obtained in the preoperative period.


Asunto(s)
Humanos , Femenino , Adulto , Persona de Mediana Edad , Complicaciones Posoperatorias/cirugía , Procedimientos Quirúrgicos Operativos/efectos adversos , Procedimientos Quirúrgicos Operativos/métodos , Triglicéridos/análisis , Triglicéridos/biosíntesis , Lipectomía/métodos , Estudios de Casos y Controles , Trastornos del Metabolismo de los Lípidos/complicaciones , Trastornos del Metabolismo de los Lípidos/diagnóstico , Abdominoplastia/efectos adversos , Abdominoplastia/métodos , Metabolismo
6.
Ocotal, Nueva Segovia; s.n; mar. 2019. 69 p. tab, graf.
Tesis en Español | LILACS | ID: biblio-1008156

RESUMEN

OBJETIVO: Determinar la relación entre las dislipidemias como factor predictivo de mal control de HTA en pacientes hipertensos controlados de la unidad de salud de Baracoa, Puerto Cortés, Honduras, 2018. MATERIAL Y MÉTODO: Estudio de Casos y controles anidados en cohorte con Muestreo no probabilístico. Se incluyeron 150 pacientes hipertensos controlados, 60 casos de pacientes con Presión arterial sistólica alta y 90 controles correspondientes a pacientes con presión arterial sistólica normal, que asistieron a la unidad de salud privada de Baracoa, Puerto Cortés en el año 2018. RESULTADOS. La edad media fue de 51 años, predominio sexo femenino 64%, la escolaridad, sexo y edad no fue significativo para el aumento de la presión arterial. Los grupos etarios con mayor afectación en el LDL fue en el rango 41-70 años (p˂0.039) lo cual muestra que hubo relación estadísticamente significativa del LDL alto con los grupos Etarios mayores. Al relacionar el colesterol HDL con la presión arterial sistólica de los pacientes estudiados se obtuvo una relación significativa de la presión sistólica con el colesterol HDL normal en los pacientes estudiados (p ˂0.032) con un OR =1.053. Se observó un aumento de riesgo (OR= 1.6) de la presión sistólica con los triglicéridos altos p =0,156 y colesterol total p=0,318 aunque esta última relación no fue estadísticamente significativa. CONCLUSIÓN: La presión arterial de los pacientes hipertensos controlados no fue afectada por la dislipidemias o patologías agregadas, el HDL normal se comprobó como factor protector para evitar presiones sistólicas altas


Asunto(s)
Humanos , Dislipidemias , Hipertensión , Estudios de Casos y Controles , Epidemiología
7.
Rev. cuba. pediatr ; 91(1): e600, ene.-mar. 2019. tab
Artículo en Español | LILACS | ID: biblio-985591

RESUMEN

Introducción: La displasia broncopulmonar es la secuela más común relacionada con los recién nacidos prematuros de muy bajo peso al nacer, derivada de la inmadurez pulmonar y en algunos casos del tratamiento. Objetivo: Identificar los factores de riesgo maternos y neonatales asociados a displasia broncopulmonar en recién nacidos prematuros de muy bajo peso al nacer. Métodos: La muestra estuvo conformada por 205 recién nacidos prematuros de muy bajo peso al nacer en el Hospital Belén de Trujillo, durante el período 2008-2015. El grupo de casos y el de controles fueron 41 pacientes con diagnóstico de displasia broncopulmonar y 164 pacientes sin diagnóstico de este trastorno respiratorio y que se ajustaran a los criterios de exclusión. Resultados: Los factores de riesgo asociados a displasia broncopulmonar fueron dos o más episodios de sepsis tardía (OR= 5,12; IC95 por ciento: 1,87-14,06), la prematuridad extrema (OR= 4,86; IC95 por ciento: 1,71-13,80), el peso extremadamente bajo al nacer (OR= 2,72; IC95 por ciento: 0,93- 7,94) y la reanimación neonatal (OR= 2,28; IC95 por ciento: 0,89-5,87). Conclusiones: La prematuridad extrema y dos episodios o más de sepsis tardía fueron los factores de riesgo que más se relacionan con la aparición de displasia broncopulmonar en recién nacidos prematuros de muy bajo peso al nacer(AU)


Introduction: Bronchopulmonary dysplasia is the most common sequelae related to very low birth weight premature infants, and it is derived from pulmonary immaturity and in some cases from treatment. Objective: To identify maternal and neonatal risk factors associated with bronchopulmonary dysplasia in very low birth weight premature infants. Methods: The sample was composed of 205 very low birth weight premature infants at Belén of Trujillo Hospital during the period 2008-2015. The group of cases and controls were 41 patients with diagnosis of bronchopulmonary dysplasia and 164 patients with no diagnosis of this respiratory disorder, respectively, and that both groups adjusted with exclusion criteria. Results: Risk factors associated with bronchopulmonary dysplasia were 2 or more episodes of late onset sepsis (OR=5.12; IC95 percent: 1,87-14,06), extreme prematurity (OR= 4.86; IC95 percent: 1.7-13.80), extremely low birth weight (OR= 2.72; IC95 percent: 0.9-7.94) and neonatal resuscitation (OR= 2.28; IC95 percent: 0.89-5.87). Conclusions: Extreme prematurity and 2 or more episodes of late onset sepsis were the most associated risk factors to the onset of bronchopulmonary dysplasia in very low birth weight premature infants(AU)


Asunto(s)
Humanos , Masculino , Femenino , Recién Nacido , Displasia Broncopulmonar/complicaciones , Recién Nacido de Bajo Peso/crecimiento & desarrollo , Recien Nacido Prematuro , Estudios de Casos y Controles , Estudios Retrospectivos , Factores de Riesgo , Estudios Observacionales como Asunto
8.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4350, 01 Fevereiro 2019. tab
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-997959

RESUMEN

Objective: To compare salivary transferrin levels between patients with oral lichen planus (OLP) and healthy subjects. Material and Methods: In this descriptive, analytical, crosssectional study, 11 patients with OLP and 22 healthy subjects were selected after matching in terms of age and gender. OLP was confirmed by two oral medicine specialists based on clinical and histopathological criteria. Salivary samples were collected by spitting. The patients were asked to collect their saliva in their oral cavity and then evacuate it into sterilized Falcon tubes. The procedure was repeated every 60 seconds for 5-15 minutes. A total of 5 mL of saliva was collected using this method. The samples were collected from 8 to 9 in the morning in a fasting state to avoid circadian changes. The collected salivary samples were immediately placed next to ice and transferred to the laboratory to be centrifuged at 4°C at 800 g to isolate squamous cells and cellular debris. Then the samples were frozen at -80°C until the samples were prepared. An ELISA kit was used to determine salivary transferrin levels. Data were analyzed with descriptive statistics (means and standard deviations) and t-test for independent groups using SPSS 17. Statistical significance was set at p<0.05. Results: The mean salivary transferrin concentrations in patients with OLP and healthy subjects were 0.9055±0.28229 and 1.5932±0.80041 mg/dL, respectively (p<0.05). Conclusion: The salivary transferrin levels in patients with OLP were significantly lower than those in healthy subjects.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Saliva , Transferrina , Diagnóstico Clínico , Liquen Plano Oral/diagnóstico , Enfermedades de la Boca/diagnóstico , Estudios de Casos y Controles , Epidemiología Descriptiva , Estudios Transversales/métodos , Técnicas Histológicas/métodos , Irán
9.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4523, 01 Fevereiro 2019. tab, graf
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-998214

RESUMEN

Objective: To compare the prostaglandin E2 (PGE2) levels of gingival crevicular fluid in generalized chronic periodontitis between healthy and type 2 diabetic patients. Material and Methods: 56 diabetic and non-diabetic participants with generalized chronic periodontitis were selected randomly. They were divided into two groups (G1: generalized chronic periodontitis patients with normal blood sugar; and G2: generalized chronic periodontitis patients with diabetes). Gingival crevicular fluid samples were obtained from both groups. The average of 2 samples per day were centrifuged in a laboratory at 2500 rpm and temperature of 4°C for 5 minutes and placed in a refrigerator at -20°C. The level of PGE2 was measured using ELISA and Abcam kit. Data were analyzed by Kolmogorov-Smirnov, Mann-Whitney U Test, Pearson and independent T tests. The significant amount was considered 0.05 in this test (α<0.05). Results: The mean level of PGE2 was significantly different in the two groups and the mean level of PGE2 in the control group was lower than the case group. There was no statistically significant relationship between PGE2 with pocket depth, fasting blood sugar (FBS) and HBA1C (p>0.05). Conclusion: PGE2 level of diabetic patient group with chronic generalized periodontitis was significantly more than non-diabetic group with generalized chronic periodontitis.


Asunto(s)
Humanos , Higiene Bucal , Enfermedades Periodontales , Estudios de Casos y Controles , Diabetes Mellitus , Periodontitis Crónica/diagnóstico , Estadísticas no Paramétricas , Irán
10.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4709, 01 Fevereiro 2019. ilus
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-998221

RESUMEN

Objective: To determine the DUSP6 gene mutation in three generations of Malaysian Malay subjects having Class III malocclusion. Material and Methods: Genetic analyses of DUSP6 gene were carried out in 30 subjects by selecting three individuals representing three generations, respectively, from ten Malaysian Malay families having Class III malocclusion and 30 healthy controls. They were submitted Clinical Evaluation to clinical examination, lateral cephalometric radiographs, dental casts, and/ or facial and intra-oral photographs. Buccal cell was taken from each participant of Class III malocclusion and control groups. DNA extractions from buccal cell were carried out using Gentra puregene buccal cell kit. Bio Edit Sequence Alignment Editor software was used to see the sequencing result. Results: A heterozygous missense mutation c.1094C>T (p. Thr 365 Ile) was identified in DUSP6 gene in three members of one family with Class III malocclusion, whereas no mutation was found in the control group. Conclusion: Current study successfully identified a missense mutation in DUSP6 gene among one Malaysian Malay family affected by Class III malocclusion. The outcome of this study broadened the mutation spectrum of Class III malocclusion and the importance of DUSP6 gene in skeletal functions.


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Variación Genética/genética , Cefalometría/métodos , Mutación Missense , Maloclusión , Arabia , Estudios de Casos y Controles , Fotografía Dental/instrumentación
11.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4653, 01 Fevereiro 2019. tab
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-998254

RESUMEN

Objective: To assess paternal education, parental occupation, family income, level of knowledge and to determine the attitude and awareness of cases and controls in relation to dental caries and its risk factors in 6-18 years old respondents. Material and Methods: A case-control study was carried out in the outpatient Department of Pediatric and Preventive Dentistry. A total of 800 subjects, 400 each in case and control group were enrolled. The cases were subjects in designated age group with dental caries while controls were subjects without dental caries but matched with the cases on three confounding factors ­ age, sex, and religion. Multivariate logistic regression was used, with a significance level set at 5%. Results: Paternal education [illiterate (p=0.002), high school (p=0.005), intermediate (p=0.001), graduate (p=0.002)], family income per month [2000 INR (30 USD) (p=0.016); 5000-10,000 INR (75USD -145 USD) (p=0.035)], attitude of short visit duration to dentist (p<0.001), knowledge about sweets causing dental caries (p<0.001), awareness about symptoms of dental caries (p<0.001) and need of lifestyle change (p<0.001) were significantly associated with dental caries. Conclusion: The present research showed that in cases, knowledge was higher as compared to controls whereas contrasting results were observed with attitude and awareness. These results necessitate an urgent need of national programme integrated with primary health care under school health and community outreach programmes, so as to encourage the population to adopt and as well as sustain dental health promoting lifestyles and practices and help in reducing the disease burden.


Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Factores Socioeconómicos , Niño , Conocimientos, Actitudes y Práctica en Salud , Adolescente , Caries Dental , India , Estudios de Casos y Controles , Estilo de Vida Saludable
12.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4802, 01 Fevereiro 2019. tab
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-998255

RESUMEN

Objective: To determine the prevalence of Candida species in the saliva of patients with clinically suspected oral potentially malignant disorders (OPMD) and healthy cohorts. Material and Methods: Unstimulated saliva was collected from patients with OPMD (n=100) and age and sex matched healthy subjects (n=170). The samples were inoculated onto Sabouraud Dextrose Agar and incubated for a week. The colonies of the isolates were enumerated using a colony counter. The isolates were identified using standard phenotypic methods. The significance of oral candidal carriage was calculated using Independent T test. Odds and Risk ratio was calculated using Pearson's Chi-square test. Results: Oral candida carriage was present in 51% of patients with OPMD while healthy cohorts had a prevalence of 20.6%. A good statistical significance was observed for the prevalence of oral candidal carriage for patients with OPMD in comparison to healthy cohorts (p=0.013). Significant Odds and risk ratio was observed for the prevalence of Candida species among OPMD. Majority of the isolates in both groups were C. albicans. Colony forming units were high among patients with OPMD. Conclusion: A significant association of oral candidal carriage to oral potentially malignant disorders in comparison to healthy cohorts was observed. Candidal species may be potent risk factor for transition of OPMD to oral Squamous Cell Carcinoma.


Asunto(s)
Humanos , Masculino , Femenino , Fenotipo , Candidiasis Bucal/prevención & control , Leucoplasia Bucal , Neoplasias de la Boca/patología , Estudios de Casos y Controles , Fibrosis de la Submucosa Bucal/patología , Candida albicans , Distribución de Chi-Cuadrado , India
13.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4991, 01 Fevereiro 2019. tab, graf
Artículo en Inglés | LILACS, BBO - Odontología | ID: biblio-998272

RESUMEN

Objective: To analyze osteopontin mRNA expression levels in subjects with periodontitis prior to (baseline) and 7, 14, and 28 days following scaling and root planing (SRP). Material and Methods: Gingival crevicular fluid was collected as clinical samples from four subjects with periodontitis (pocket depth, 4-5 mm) aged 35-54 years old as well as from three healthy subjects (controls). The osteopontin mRNA expression levels were measured by quantitative real-time polymerase chain reaction. Spearman's rank correlation between osteopontin levels in gingival crevicular fluid and the modified gingival index (MGI) was also performed. Results: The Wilcoxon signed-rank test showed no significant difference in osteopontin mRNA expression levels between baseline and 28 days following SRP (p=0.068). The Friedman test showed no significant difference in osteopontin mRNA expression levels between baseline and following SRP (7, 14, or 28 days) (p>0.05). Spearman's rank correlation showed no significant correlation between osteopontin mRNA expression levels and MGI (r=0.087; p=0.749). Conclusion: Following SRP of periodontal tissue, there was a decreasing trend in osteopontin mRNA expression; however, this finding was not statistically significant. Nevertheless, osteopontin can be used as a biomarker to monitor the healing process; however, further studies are required to clarify our results.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Periodontitis , ARN Mensajero , Aplanamiento de la Raíz/métodos , Osteopontina , Estudios de Casos y Controles , Estadísticas no Paramétricas , Indonesia
14.
Mem. Inst. Oswaldo Cruz ; 114: e180579, 2019. tab, graf
Artículo en Inglés | LILACS | ID: biblio-1002686

RESUMEN

BACKGROUND CD64 (FcγR1) is a high-affinity receptor for monomeric IgG1 and IgG3. Circulating neutrophils express very low amounts of CD64 on their surface. OBJECTIVES Our primary aim was to investigate the utility of neutrophil CD64 surface expression as a biomarker of active pulmonary tuberculosis (TB). We hypothesised that elevated neutrophil CD64 expression in TB infection would be associated with interferon gamma (IFN-γ) as an inducer of CD64 expression. METHODS The expression level of CD64 per neutrophil (PMN CD64 index) was quantitatively measured with flow cytometry using a Leuko64 kit in samples from patients with TB and latent TB infection (LTBI) as well as healthy controls, as part of a prospective cohort study in Brazil. FINDINGS The PMN CD64 index in patients with TB was higher than that in healthy controls and LTBI. Receiver operating characteristic curve analyses determined that the PMN CD64 index could discriminate patients with TB from those with LTBI and healthy individuals. PMN CD64 index levels returned to baseline levels after treatment. CONCLUSIONS The positive regulation of CD64 expression in circulating neutrophils of patients with active TB could represent an additional biomarker for diagnosis of active TB and could be used for monitoring individuals with LTBI before progression of TB disease.


Asunto(s)
Humanos , Biomarcadores/análisis , Tuberculosis Latente/diagnóstico , Tuberculosis Latente/inmunología , Citometría de Flujo , Estudios de Casos y Controles , Estudios Prospectivos , Ensayos de Liberación de Interferón gamma , Neutrófilos/inmunología
15.
Rev. ABENO ; 19(1): 20-32, 2019. tab
Artículo en Portugués | LILACS, BBO - Odontología | ID: biblio-1022120

RESUMEN

O estudo visa obter percepções críticas de formandos em Odontologia sobre o estágio curricular no SUS. Realizou-se pesquisa exploratória, descritiva e qualitativa junto à população de acadêmicos concluintes do curso de Odontologia de uma universidade pública do sul do Brasil (n= 52) (ano base: 2016), considerando-se para fins de análise somente os acadêmicos que julgaram que o estágio no SUS não foi produtivo para a sua formação acadêmica (n=11). A apreensão das informações se deu por meio de questão norteadora única e os resultados foram tratados de acordo com a técnica de análise do discurso do sujeito coletivo. Das informações obtidas foram extraídos dois temas 'Organização' e 'Estrutura' do estágio, e sete ideias centrais, as quais deram origem aos discursos. Os acadêmicos expõem importância arraigada ao modelo de atuação profissional tecnicista, com baixo interesse no SUS enquanto campo de trabalho (AU).


The study aims at obtaining critical perceptions of Dentistry graduating students about the supervised intership in the Unified Health System. An exploratory, descriptive and qualitative research was carried out with the population composed by Dentistry graduating students of a public university in southern Brazil (n=52) (base year: 2016), considering only the ones who judged that the supervised intership in the Unified Health System was not productive for their professional qualification (n=11). The information was apprehended by means of a single guiding question and the results were treated according to the discourse of the collective subject technique. From the information obtained, two themes, 'Organization' and 'Structure' of the supervised intership, and seven central ideas, which originated the discourses, were extracted. The students expose the importance focused on the technicist model of approach, with low interest in the Unified Health System as a field of work (AU).


Asunto(s)
Estudiantes de Odontología , Evaluación Educacional/métodos , Brasil , Estudios de Casos y Controles , Interpretación Estadística de Datos , Investigación Dental , Instituciones de Enseñanza Superior , Estudios Observacionales como Asunto
16.
Rev. ABENO ; 19(1): 33-39, 2019. tab
Artículo en Portugués | LILACS, BBO - Odontología | ID: biblio-1022125

RESUMEN

O presente estudo observacional do tipo caso-controle avaliou o impacto da participação no Programa de Iniciação Científica (PIC) no coeficiente de rendimento (CR) acadêmico de graduandos em Odontologia. Alunos de uma instituição de ensino superior (IES) particular localizada em Campinas (SP) foram divididos em dois grupos: caso (GCs; vinculados ao PIC 2013 a 2016) e controle (GCt estudantes matriculados e/ou egressos que se enquadraram aos critérios de inclusão). Calculou-se o CR dos participantes, ponderado pela carga horária das disciplinas, sendo para o GCs: nos semestres anteriores à participação no PIC e nos semestres letivos cursados em concomitância ou posteriormente à 1ª participação no programa. Para o GCt, considerou-se o CR dos semestres cursados. Vincularam-se ao PIC 58 estudantes, sendo 15,5% (9) na 1ª edição (2013-2014); 27,6% (16) na 2ª (2014-2015); 29,3% (17) na 3ª (2015-2016) e 27,6% (16) na 4ª edição (2016-2017). Dentre os aptos a participar do GCt, sorteou-se 60 estudantes. Verificou-se que houve um aumento significativo (p<0,0001, teste t pareado) nos CRs calculados para GCs antes do PIC (7,73±0,49) e depois do PIC (7,89±0,46). Estudantes GCs tiveram CR mais alto do que aqueles do GCt (7,45±0,56), tanto previamente quanto após sua participação no PIC (p< 0,0001, teste t para uma média). Concluise que o estímulo à iniciação científica por meio da institucionalização de programas acadêmicos diferencia o rendimento escolar dos participantes (AU).


This observational, case-control type study evaluated the impact of participation in a Research Mentorship Program (RMP) on the academic performance coefficient (PC) of undergraduates of a dentistry course. Students from a private higher education institution (HEI) located in Campinas (SP) were divided into two groups: case (CGs; who participated in the RMP between 2013 and 2016) and control (CTGs, enrolled students and/or graduates who met the inclusion criteria). The PC of the participants was calculated, considering the study hours of the subjects. Those of the CGs were based on the semesters prior to participation in the RMP and those taught concurrently or after first participation in the program. For the CTGs all semesters studied were considered. A total of 58 students were linked to the RMP, with 15.5% (9) in the 1st edition (2013-2014); 27.6% (16) in the 2nd (2014-2015); 29.3% (17) in the 3rd (2015-2016) and 27.6% (16) in the 4th edition (2016-2017). A total of 60 students were randomly selected for inclusion in the CTG. It was found that there was a significant increase in the calculated PCs of the CGs (p<0.0001, paired t test) from before (7.73 ± 0.49) to after the RMP (7.89 ± 0.46). CG students had a higher PC than students of the CTG (7.45 ± 0.56), both before and after their participation in the RMP (p<0.0001, one sample t-test) ). It can be concluded that research mentorship stimulus through the establishing of academic programs makes a difference to the scholastic performance of the participants (AU).


Asunto(s)
Humanos , Masculino , Femenino , Estudiantes de Odontología , Investigación Dental , Evaluación Educacional/métodos , Instituciones de Enseñanza Superior , Rendimiento Académico , Brasil , Estudios de Casos y Controles , Interpretación Estadística de Datos , Estudios Observacionales como Asunto
17.
Acta odontol. Colomb. (En linea) ; 9(1): 9-23, 2019. Ilus, Tab
Artículo en Español | LILACS, COLNAL | ID: biblio-1000030

RESUMEN

Objetivo: identificar los factores de riesgo de la atrición dental severa en pacientes que acudieron a instituciones de atención odontológica, públicas y privadas, de la ciudad de Cuenca, Ecuador. Materiales y métodos: fueron analizados 237 pacientes adultos, 79 casos con atrición dental grados 2, 3 y 4, según el índice de Smith y Knight, y 158 contro- les con atrición grados 0 y 1. Se realizó un examen clínico y fotográfico para determinar la relación entre la atrición dental y factores como edad, sexo, procedencia, número de dientes residuales, pH salival y bruxismo. Resultados: los pacientes mayores de 25 años (OR= 2,47; IC= 1,41 ­ 4,35; X2= 10,21; p= 0,001), con menos de 20 dientes en boca (OR= 4,95; IC= 1,47 ­ 16,62; X2= 7,97; p= 0,004 ) y con bruxismo (OR= 2,64; IC= 1,45 ­ 4,81; X2= 10,49; p= 0,001) tienen más probabilidades de presentar atrición dental severa. Luego de una regresión logística binaria se confirmó dicha relación: pacientes mayores de 25 años (OR= 2,03; IC= 1,08 ­ 3,818) con menos de 20 dientes en boca (OR= 3,90; IC= 1,07 ­ 14,19) y con bruxismo (OR= 3,22; IC= 1,70 ­ 6,10); sin embargo, se observó una capacidad predictora muy baja de la variables ajustadas según el R­cuadrado de Cox y Snell (0,123) y el R­cuadrado de Nagelkerke (0,172). Conclusiones: edad avanzada, menor cantidad de dientes en boca y bruxismo aumentaron la posibilidad de presentar atrición dental severa en los pacientes analizados. Mientras que el sexo masculino, la procedencia rural y el pH salival crítico (menor a 6) no se comportaron como factores de riesgo.


Asunto(s)
Humanos , Bruxismo , Atrición Dental , Saliva , Estudios de Casos y Controles , Factores de Riesgo , Arcada Parcialmente Edéntula , Adulto , Ecuador , Desgaste de los Dientes
18.
Rev. méd. panacea ; 7(3): 83-88, sept.-dic. 2018. tab
Artículo en Español | LILACS | ID: biblio-1016812

RESUMEN

Objetivo: Determinar los factores de riesgo que influyen en el fracaso al tratamiento individualizado de Tuberculosis Multidrogorresistente en la provincia de Ica. 2000-2014. Materiales y métodos: Estudio observacional, retrospectivo, tipo analítico, de casos y controles. La muestra estuvo conformada por 19 casos de fracaso al tratamiento individualizado, y por cada caso se tuvo dos controles de pacientes que curaron con tratamiento individualizado. Se realizó el análisis bivariado con un nivel de significancia del 5% se calculó del Odds Ratio (OR) con intervalo de confianza (IC) al 95%. Se realizó análisis de regresión logística. Resultados: En el análisis multivariado resultaron 4 factores de riesgo asociados a fracaso al tratamiento individualizado: resistencia a 5 o más drogas (OR=6,67, p=0,027), tener IMC menor de 18.5 al inicio del tratamiento (OR=7,61 p=0,023), presentar hemoptisis durante el tratamiento (OR= 19,89, P=0,001) y la presencia de cavernas en la radiografía de tórax inicial (OR=27,95, p=0,005). Conclusiones: Los pacientes con resistencia a 5 o más drogas antituberculosas, con IMC menor a 18.5, con hemoptisis durante el tratamiento y los que presentan caverna en la radiografía de tórax, tienen mayor riesgo de fracasar al tratamiento individualizado. (AU)


Objective: To determine the risk factors that influence the failure to individualized treatment of multidrug-resistant tuberculosis in the province of Ica. 2000-2014. Materials and methods:Observational, retrospective study, analytical type, of cases and controls. The sample consisted of 19 cases of failure to individualized treatment, and for each case there were two controls of patients who cured with individualized treatment. The bivariate analysis was performed with a level of significance of 5% was calculated from the Odds Ratio (OR) with 95% confidence interval (CI). Logistic regression analysis was performed. Results: In the multivariate analysis, there were 4 risk factors associated with failure to individualized treatment: resistance to 5 or more drugs (OR = 6.67, p = 0.027), having a BMI less than 18.5 at the beginning of treatment (OR = 7, 61 p = 0.023), presenting hemoptysis during treatment (OR = 19.89, P = 0.001) and the presence of caverns on the initial chest radiograph (OR = 27.95, p = 0.005). Conclusions: Patients with resistance to 5 or more antituberculous drugs, with a BMI less than 18.5, with hemoptysis during treatment and those who have a cavern on chest radiography, have a higher risk of failing individualized treatment. (AU)


Asunto(s)
Humanos , Masculino , Femenino , Factores de Riesgo , Tuberculosis Resistente a Múltiples Medicamentos , Tuberculosis Resistente a Múltiples Medicamentos/terapia , Estudios de Casos y Controles , Estudios Retrospectivos , Estudios Observacionales como Asunto
19.
Rev. bras. med. esporte ; 24(6): 471-476, Nov.-Dec. 2018. tab, graf, ilus
Artículo en Inglés | LILACS | ID: biblio-977855

RESUMEN

INTRODUCTION: Eccentric training and jump tests are widely used to recover and measure deficits in knee strength and functionality after anterior cruciate ligament (ACL) reconstruction. OBJECTIVE: To correlate knee extension and flexion torque generated by eccentric isokinetic training, with functional jump tests in subjects with reconstructed ACL. METHOD: Sixteen men with unilateral ACL reconstruction were assessed before and after 12 weeks of eccentric isokinetic training of knee flexors and extensors (3×10 MVC, 2x/week) at 30°/s for extension and flexion torque (isometric; concentric and eccentric at 30 and 120°/s) and functional jump tests (single, triple, cross and figure of 8). Inter- and intra-limb pre- and post-training mean peak torque (MPT), distance and jump test times were compared along with the correlations between these variables, considering P<0.05. RESULTS: The affected limb (AL) showed significant gain of extension and flexion torque (P<0.01) in the different test categories and velocities evaluated. In the non-affected limb (NAL), this only occurred in the eccentric category (30 and 120°/s), in the extension (P<0.01) and flexion (P<0.05 and P<0.01) torques, respectively. In the jumps, there was an increase in distance (single and triple; P<0.05) and a decrease in time (crossed and figure of 8; P<0.01), however, MPT x Jump correlations were weak (r<0.3) in the pre and post-training period in both limbs. CONCLUSION: Despite the gain in knee extension and flexion torque and jumping performance, the expected correlation was not satisfactory, suggesting that knee functionality involves other variables inherent to motor control. Level of Evidence IV; Type of study: Case series.


INTRODUÇÃO: O treino excêntrico e testes de saltos são muito utilizados para recuperar e aferir déficits de força e funcionalidade do joelho, após reconstrução do ligamento cruzado anterior (LCA). OBJETIVO: Correlacionar o torque extensor e flexor do joelho, gerados pelo treino isocinético excêntrico, com testes funcionais de saltos em sujeitos com LCA reconstruído. MÉTODO: Foram avaliados 16 homens, com reconstrução unilateral do LCA, antes e depois de 12 semanas de treino isocinético excêntrico de extensores e flexores do joelho (3 × 10 CEVM, 2x/semana) a 30°/s, quanto ao torque extensor e flexor (isométrico; concêntrico e excêntrico a 30°/s e 120°/s) e aos testes funcionais de saltos (simples, triplo, cruzado e figura em 8). As médias dos picos de torque (MPT), a distância e os tempos dos testes de salto inter e intramembros, pré e pós-treino foram comparados, além das correlações entre essas variáveis, considerando P< 0,05. RESULTADOS: O membro acometido (MA) mostrou ganho significativo de torque extensor e flexor (P< 0,01) nos modos e velocidades avaliados. No membro não acometido (MNA), isso ocorreu apenas para o modo excêntrico (30°/s e 120°/s), do torque extensor (P< 0,01) e flexor (P< 0,05 e P<0,01), respectivamente. Nos saltos, houve aumento da distância (simples e triplo; P< 0,05) e diminuição do tempo (cruzado e figura em 8; P< 0,01), porém, as correlações entre MPT e saltos mostraram-se fracas nos dois membros (r< 0,3) antes e depois do treino. CONCLUSÃO: Apesar do ganho no torque extensor e flexor do joelho e no rendimento dos saltos, a correlação esperada não foi satisfatória, sugerindo que a funcionalidade do joelho envolve outras variáveis inerentes ao controle motor. Nível de evidência IV; Tipo de estudo: Série de casos.


INTRODUCCIÓN: El entrenamiento excéntrico y las pruebas de saltos son muy utilizados para recuperar y medir los déficits de fuerza y funcionalidad de la rodilla, después de la reconstrucción del ligamento cruzado anterior (LCA). OBJETIVO: Correlacionar el torque extensor y flexor de la rodilla, generados por el entrenamiento isocinético excéntrico, con pruebas funcionales de saltos en sujetos con LCA reconstruido. MÉTODO: Fueron evaluados 16 hombres, con reconstrucción unilateral del LCA, antes y después de 12 semanas de entrenamiento isocinético excéntrico de extensores y flexores de la rodilla (3x10 CEVM, 2x/semana) a 30°/s, cuanto al torque extensor y flexor (isométrico, concéntrico y excéntrico a 30 y 120°/s) y a las pruebas funcionales de saltos (simple, triple, cruzado y figura en 8). Se compararon promedios de los picos de torque (MPT), distancia y tiempos de las pruebas de salto, inter e intra-miembros, pre y post-entrenamiento, además de las correlaciones entre estas variables, considerando P<0,05. RESULTADOS: El miembro acometido (MA) mostró aumento significativo del torque extensor y flexor (P<0,01) en los modos y velocidades evaluados. En el miembro no acometido (MNA), eso ocurrió sólo para el modo excéntrico (30 y 120°/s), del torque extensor (P<0,01) y flexor (P<0,05 y P<0,01), respectivamente. En los saltos, hubo aumento en la distancia (simple y triple; P<0,05) y disminución del tiempo (cruzado y figura en 8; P<0,01), sin embargo, las correlaciones MPT x saltos se mostraron débiles (r<0,3) en el pre y post-entrenamiento, en los dos miembros. CONCLUSIÓN: A pesar del aumento en el torque extensor y flexor de la rodilla y en el rendimiento de los saltos, la correlación esperada no fue satisfactoria, sugiriendo que la funcionalidad de la rodilla involucra otras variables inherentes al control motor. Nivel de evidencia IV; Tipo de estudio: Serie de casos


Asunto(s)
Humanos , Masculino , Adulto , Persona de Mediana Edad , Adulto Joven , Fuerza Muscular , Reconstrucción del Ligamento Cruzado Anterior/rehabilitación , Articulación de la Rodilla/cirugía , Resistencia Física , Ejercicio , Estudios de Casos y Controles , Prueba de Esfuerzo/métodos
20.
Rev. habanera cienc. méd ; 17(4): 540-554, jul.-ago. 2018. tab, graf
Artículo en Español | LILACS | ID: biblio-978550

RESUMEN

Introducción: La artritis reumatoide es una enfermedad autoinmune caracterizada por la presencia de anticuerpos contra péptidos citrulinados, que constituyen indicadores para el diagnóstico de la enfermedad. Es necesario determinar la utilidad de diferentes métodos de determinación de estos anticuerpos para el diagnóstico de pacientes cubanos con artritis reumatoide. Objetivo: Determinar la eficacia de los ensayos de determinación de anticuerpos anti-CCP2 y anti-CCP3 para el diagnóstico de pacientes cubanos con artritis reumatoide. Material y método: Participaron 101 pacientes con artritis reumatoide, 58 pacientes con otras enfermedades reumáticas e inflamatorias y 43 individuos sanos. Se determinó la eficacia diagnóstica de los anticuerpos factor reumatoideo (FR), anti-CCP2 y anti-CCP3 medidos mediante ELISA, con el cálculo de la sensibilidad, especificidad, valores predictivos positivos y negativos. Resultados: El ensayo anti-CCP2 mostró un mejor balance sensibilidad (48,5 por ciento) y especificidad (98,0 por ciento). Cuando se fijó la especificidad a 98 por ciento, se observó la menor sensibilidad para el FR (40,3 por ciento). Utilizar los ensayos anti-CCP2 y FR aumentó la especificidad a 100 por ciento. Todos los autoanticuerpos mostraron asociación con la proteína C reactiva y correlación con la velocidad de sedimentación globular. Solamente los anticuerpos anti-CCP2 no mostraron correlación con el indicador clínico de actividad DAS 28. Conclusiones: Los anticuerpos anti-CCP2 son los de mayor eficacia para el diagnóstico de pacientes cubanos con artritis reumatoide. La determinación de FR permite identificar pacientes con artritis reumatoide seronegativos de anticuerpos anti-CCP2, por lo que la combinación de ambos inmunoensayos produce una mejoría en la eficacia diagnóstica(AU)


Introduction: Rheumatoid arthritis is an autoimmune disease characterized by the presence of antibodies against citrullinated peptides, which are one of the indicators for the diagnosis of a disease. The usefulness of different methods for the determination of these antibodies in the diagnosis of Cuban patients with rheumatoid arthritis is necessary to be established. Objective: To establish the diagnostic effectiveness of the second (anti-CCP2) and third (anti-CCP3) generation assays for the determination these antibodies against citrullinated peptides in Cuban patients with rheumatoid arthritis. Material and method: 101 patients with rheumatoid arthritis, 58 patients with other rheumatic and inflammatory diseases, and 43 healthy persons participated in the study. The diagnostic efficiency of rheumatoid factor (RF), anti-CCP2 and anti-CCP3 antibodies were determined using ELISA test, by calculating sensitivity, specificity, and positive and negative predictive values. Results: The anti-CCP2 assay showed a better balance of sensitivity (48.5 percent) and specificity (98.0 percent). The lower sensibility was observed for RF (40.3 percent) when the specificity was set at 98 percent. Specificity increased to 100 percent when anti-CCP2 and RF assays were used. All autoantibodies showed association with C-reactive protein and correlation with erythrocyte sedimentation rate. Only anti-CCP2 antibodies showed no correlation with the DAS28 clinical indicator. Conclusions: Anti-CCP2 antibodies are the ones of greater effectiveness in the diagnosis of Cuban patients with rheumatoid arthritis. RF identification allows to identify seronegative anti-CCP2 patients; therefore, the combination of both immunoassays leads to an improvement in the diagnostic effectiveness(AU)


Asunto(s)
Humanos , Masculino , Femenino , Artritis Reumatoide/diagnóstico , Técnicas y Procedimientos Diagnósticos/normas , Anticuerpos Antiproteína Citrulinada/inmunología , Estudios de Casos y Controles , Anticuerpos Antiproteína Citrulinada/uso terapéutico , Anticuerpos
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