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1.
Praxis (Bern 1994) ; 109(1): 31-34, 2020 Jan.
Artículo en Alemán | MEDLINE | ID: mdl-31910767

RESUMEN

CoLaus: Diet, the Forgotten Key to Preventing Cardiovascular Diseases Abstract. Healthy eating is paramount for the prevention and management of cardiovascular diseases. Still, data from the CoLaus study show that dietary management of cardiovascular risk factors and cardiovascular disease is little implemented. Less than one fifth of participants with dyslipidemia reported being on a hypolipidemic diet, and only half of participants with diabetes reported being on an antidiabetic diet. Further, the occurrence of a myocardial infarction was not associated with an improvement in dietary quality.


Asunto(s)
Enfermedades Cardiovasculares , Diabetes Mellitus , Dieta , Dislipidemias , Enfermedades Cardiovasculares/prevención & control , Diabetes Mellitus/prevención & control , Dislipidemias/prevención & control , Humanos
2.
Biochem Med (Zagreb) ; 30(1): 010704, 2020 Feb 15.
Artículo en Inglés | MEDLINE | ID: mdl-31839724

RESUMEN

Introduction: Diabetes mellitus (DM) is one of the most prevalent diseases worldwide. The objective of this study was to find out under what preanalytical conditions routine and diagnostic glucose tests are performed across Spanish laboratories; and also what criteria are used for DM diagnosis. Materials and methods: An online survey was performed by the Commission on Quality Assurance in the Extra-Analytical Phase of the Spanish Society of Laboratory Medicine (SEQC-ML). Access to the questionnaire was available on the home page of the SEQC-ML website during the period April-July 2018. Data analysis was conducted with the IBM SPSS© Statistics (version 20.0) program. Results: A total of 96 valid surveys were obtained. Most laboratories were in public ownership, serving hospital and primary care patients, with high and medium workloads, and a predominance of mixed routine-urgent glucose testing. Serum tubes were the most used for routine glucose analysis (92%) and DM diagnosis (54%); followed by lithium-heparin plasma tubes (62%), intended primarily for urgent glucose testing; point-of-care testing devices were used by 37%; and plasma tubes with a glycolysis inhibitor, mainly sodium fluoride, by 19%. Laboratories used the cut-off values and criteria recognized worldwide for DM diagnosis in adults and glucose-impaired tolerance, but diverged in terms of fasting plasma glucose and gestational DM criteria. Conclusion: Preanalytical processing of routine and DM diagnostic glucose testing in Spain does not allow a significant, non-quantified influence of glycolysis on the results to be ruled out. Possible adverse consequences include a delay in diagnosis and possible under-treatment.


Asunto(s)
Glucemia/análisis , Recolección de Muestras de Sangre/métodos , Recolección de Muestras de Sangre/instrumentación , Diabetes Mellitus/diagnóstico , Humanos , Laboratorios de Hospital/normas , Fase Preanalítica , España , Encuestas y Cuestionarios
3.
Angiology ; 71(1): 17-26, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31129986

RESUMEN

The Middle East and North Africa (MENA) region has a high burden of morbidity and mortality due to premature (≤55 years in men; ≤65 years in women) myocardial infarction (MI) and acute coronary syndrome (ACS). Despite this, the prevalence of risk factors in patients presenting with premature MI or ACS is incompletely described. We compared lifestyle, clinical risk factors, and biomarkers associated with premature MI/ACS in the MENA region with selected non-MENA high-income countries. We identified English-language, peer-reviewed publications through PubMed (up to March 2018). We used the World Bank classification system to categorize countries. Patients with premature MI/ACS in the MENA region had a higher prevalence of smoking than older patients with MI/ACS but a lower prevalence of diabetes, hypertension, and dyslipidemia. Men with premature MI/ACS had a higher prevalence of smoking than women but a lower prevalence of diabetes and hypertension. The MENA region had sparse data on lifestyle, diet, psychological stress, and physical activity. To address these knowledge gaps, we initiated the ongoing Gulf Population Risks and Epidemiology of Vascular Events and Treatment (Gulf PREVENT) case-control study to improve primary and secondary prevention of premature MI in the United Arab Emirates, a high-income country in the MENA region.


Asunto(s)
Síndrome Coronario Agudo/epidemiología , Infarto del Miocardio/epidemiología , Síndrome Coronario Agudo/mortalidad , Síndrome Coronario Agudo/prevención & control , África del Norte/epidemiología , Edad de Inicio , Anciano , Estudios de Casos y Controles , Comorbilidad , Diabetes Mellitus/epidemiología , Dislipidemias/epidemiología , Femenino , Humanos , Hipertensión/epidemiología , Masculino , Persona de Mediana Edad , Medio Oriente/epidemiología , Mortalidad Prematura , Infarto del Miocardio/mortalidad , Infarto del Miocardio/prevención & control , Prevalencia , Prevención Primaria , Pronóstico , Proyectos de Investigación , Factores de Riesgo , Prevención Secundaria , Factores Sexuales , Fumar/efectos adversos , Fumar/epidemiología
4.
Rev. Pesqui. (Univ. Fed. Estado Rio J., Online) ; 12: 257-262, jan.-dez. 2020. tab
Artículo en Inglés, Portugués | LILACS, BDENF - Enfermería | ID: biblio-1047911

RESUMEN

Objetivo: identificar o perfil epidemiológico dos usuários atendidos em ação de saúde na Baixada Litorânea do Rio de Janeiro. Método: trata-se de um estudo descritivo, retrospectivo, exploratório de natureza quantitativa que utilizou como delineamento a pesquisa documental por meio da análise de dados secundários. Resultados: foram avaliados 746 registros, com prevalência do sexo feminino (69,7%), idade entre 20 e 29 anos (41,6%), ensino superior incompleto (63,9%) e estado civil solteiro (69,4%). O sexo masculino apresentou uma média mais elevada de níveis pressóricos quando comparado com as mulheres. Evidenciou-se que com o avançar da idade e baixa escolaridade, maiores são os níveis de pressão arterial e glicêmicos. Conclusão: estudos que ampliam o conhecimento sobre o perfil epidemiológico de uma população representam uma ferramenta importante para subsidiar o cuidado em saúde


Objective: to reveal the epidemiological profile of the users met in health action in the Coastal Lowlands of Rio de Janeiro. Method: this is a descriptive study, retrospective, exploratory quantitative in nature used as documentary research design through the analysis of secondary data. Results: 746 records were evaluated, with female prevalence (69.7%), age between 20 and 29 years (41.6%), incomplete higher education (63.9%) and marital status single (69.4%). Males showed an average blood pressure higher when compared with the female. It was evidenced that with advancing age and lower educational level, the greater the blood pressure and blood glucose levels. Conclusion: it is considered that studies about the knowledge of the epidemiological profile of a population becomes an important tool to support health actions


Objetivo: identificar el perfil epidemiológico de los usuarios se reunieron en la acción sanitaria en las tierras bajas costeras de Río de Janeiro. Método: se trata de un estudio descriptivo, retrospectivo, utilizado cuantitativo en naturaleza exploratoria como diseño de investigación documental a través del análisis de datos secundarios. Resultados: se evaluaron registros de 746, con predominio femenino (69.7%), edad entre 20 y 29 años (41.6%), educación superior incompleta (63.9%) y el estado civil solo (69,4%). Los varones mostraron mayor los niveles de presión arterial media en comparación con las mujeres. Se evidenció que con el avance de edad y menor nivel educativo, mayor será los niveles de glucosa en sangre y presión arterial. Conclusión: estudios que amplían el conocimiento sobre el perfil epidemiológico de una población representan una herramienta importante para apoyar la atención de la salud


Asunto(s)
Humanos , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Enfermedad Crónica/epidemiología , Estudios Retrospectivos , Enfermedades no Transmisibles/epidemiología , Factores Socioeconómicos , Perfil de Salud , Brasil/epidemiología , Diabetes Mellitus , Hipertensión
8.
Medicine (Baltimore) ; 98(50): e18100, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31852069

RESUMEN

INTRODUCTION: Pulse wave analysis is an emerging approach that analyzes parameters comprising strong predictors of cardiovascular (CV) events and all-cause mortality, especially in patients with high CV risk based on established risk factors. This study used the oscillometric method, provided by the Mobil-o-Graph (PWA-EMI GmbH, Stolberg, Germany) device, to compare data regarding the pulse wave analysis parameters in hypertensive nondiabetic and diabetic patients. MATERIAL AND METHODS: In this cross-sectional study, 276 individuals were examined in the academic hypertension outpatient care unit of the Federal University of the Triângulo, in Mineiro, Brazil, from January to December 2016. The pulse wave analysis was performed by oscillometry, and its parameters were acquired from all patients. RESULTS: Of the 276 patients, 99 were diabetic and 177 nondiabetic. The mean systolic and pulse central blood pressure were significantly higher in diabetic patients than in nondiabetic patients (P = .008 and.0003, respectively). The mean peripheral systolic blood pressure and pulse pressure were also significantly higher in the diabetic group (P = .001 and P < .0001, respectively). The average pulse wave velocity (PWV, m/s) was 9.4 ±â€Š1.6 and 8.8 ±â€Š1.6 in the diabetic and nondiabetic groups, respectively (P = .003). CONCLUSION: The group of hypertensive diabetic patients had significantly higher central blood pressure, peripheral blood pressure, and PWV than the hypertensive nondiabetic patients. The patients with overlapping established CV risk factors presented values of the pulse wave analysis parameters consistent with higher central pressure and greater arterial stiffness.


Asunto(s)
Atención Ambulatoria , Presión Sanguínea/fisiología , Diabetes Mellitus/fisiopatología , Hipertensión/fisiopatología , Oscilometría/métodos , Análisis de la Onda del Pulso/métodos , Rigidez Vascular/fisiología , Brasil/epidemiología , Estudios Transversales , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/epidemiología , Femenino , Estudios de Seguimiento , Humanos , Hipertensión/diagnóstico , Hipertensión/epidemiología , Incidencia , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Reproducibilidad de los Resultados , Factores de Riesgo , Sístole
9.
MMWR Morb Mortal Wkly Rep ; 68(43): 961, 2019 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-31851648

RESUMEN

November is National Diabetes Month. In the United States, 30 million adults aged ≥18 years are living with diabetes and 84 million with prediabetes (1). Among persons aged ≥65 years, one in four is estimated to have diabetes, and one in two has prediabetes (1). Persons with prediabetes are at risk for developing type 2 diabetes, heart disease, and stroke (2). However, type 2 diabetes can be prevented or delayed through a structured lifestyle change program that promotes weight loss, healthy eating, and increased physical activity (2). A report on diabetes among Medicare beneficiaries is included in this issue of MMWR (3).


Asunto(s)
Diabetes Mellitus/prevención & control , Aniversarios y Eventos Especiales , Humanos , Estados Unidos
10.
Indian J Dent Res ; 30(5): 703-707, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31854360

RESUMEN

Background: Oral cytology studies have claimed that cytoplasmic Periodic Acid Schiff (PAS) positivity in type-2 diabetics is due to glycogen content. But, it can also be due to mucin and glycoconjugates. Aim: 1. To confirm that cytoplasmic PAS positivity in type-2 diabetics is due to glycogen using diastase. 2. To know the effect of diabetes by determining the number of glycogen-containing cells in the smear. 3. To assess the impact of duration of diabetes based on PAS staining of cells. 4. To correlate between random blood glucose level and the number of PAS-positive cells. Materials and Methods: Study population comprised 45 individuals with 30 type-2 diabetics as case group (Group I < 5 years duration; Group II > 5 years duration) and 15 healthy volunteers (age and gender-matched) as control. For all subjects, random blood glucose was estimated and two cytosmears were obtained. The smears were stained with PAS and PAS-diastase stains (PAS-D). Staining intensity was documented as score 1 (mild-to-moderate) and score 2 (moderate-to-intense) and data obtained were statistically analyzed in SPSS version 16.0. Results: Mann-Whitney U test revealed that in diabetics cytoplasmic PAS positivity is because of glycogen (P < 0.05). There is an increase in the number of glycogen-containing cells (P < 0.05) in diabetics. The duration of diabetes had less impact on intracellular glycogen accumulation (P > 0.05). Spearman's correlation test revealed no significant correlation (P > 0.05) between random blood glucose and a number of PAS-positive cells. Conclusion: PAS positivity is because of intracellular glycogen accumulation in type-2 diabetics. It can convey the glycaemic status of an individual in the recent past, thus a beneficial role in screening and therapeutic monitoring.


Asunto(s)
Diabetes Mellitus , Glucógeno , Glucemia , Colorantes , Humanos , Reacción del Ácido Peryódico de Schiff , Coloración y Etiquetado
11.
Zhongguo Zhong Yao Za Zhi ; 44(18): 3869-3875, 2019 Sep.
Artículo en Chino | MEDLINE | ID: mdl-31872717

RESUMEN

Mahuang Fuzi Xixin Decoction recorded in Treatise on Febrile Diseases by Zhang Zhongjing in the Han Dynasty have been widely used in treating Yang deficiency and exogenous wind-cold syndrome by traditional Chinese medicine physicians for thousands of years. The indications of Mahuang Fuzi Xixin Decoction include bradyarrhythmia,sinus bradycardia,sick sinus node syndrome,senile exogenous,asthmatic cold,rhinitis,bronchial asthma,optic neuritis,optic atrophy,sudden blindness,sudden onset of cough,laryngeal obstruction,migraine,joint pain,low back pain,insomnia,shock,heart failure,renal failure,accompanied by fever or nosocomial infection,and hyperpyrexia after tracheotomy; dark complexion,chills,cold limbs,listlessness,fatigue,insomnia,lack of thirst,liking hot drinks,slightly swollen limbs or whole body,pale fat tongue,greasy fur,and deep pulse. Mahuang Fuzi Xixin Decoction is a potential drug for Shaoyin disease complicated with fever and pain. Tracheal intubation is an artificial ephedrine syndrome. It is necessary to distinguish Yin and Yang syndrome in treating hyperpyrexia after tracheotomy. However,it belongs to Yin syndrome,which could be treated by Mahuang Fuzi Xixin Decoction. Mahuang Fuzi Xixin Decoction is effective in the treatment of sick sinus syndrome,second degree atrioventricular block and third degree atrioventricular block. It can significantly alleviate symptoms,improve heart rate,and heart rhythm in a short period of time. However,after one year of drug withdrawal,the diseases may recur,indicating that Mahuang Fuzi Xixin Decoction may not improve the long-term prognosis of slow arrhythmia. Mahuang Fuzi Xixin Decoction is often used for fever or nosocomial infection in critical care medicine. In the treatment of critical care medicine complicated with high fever,Mahuang Fuzi Xixin Decoction is often taken continuously by stomach tube.


Asunto(s)
Infección Hospitalaria/tratamiento farmacológico , Neuropatías Diabéticas/complicaciones , Medicamentos Herbarios Chinos/farmacología , Fiebre/tratamiento farmacológico , Infarto del Miocardio/complicaciones , Dolor Postoperatorio/tratamiento farmacológico , Traqueotomía/efectos adversos , Cuidados Críticos , Diabetes Mellitus , Humanos , Medicina China Tradicional , Fitoterapia , Síndrome
12.
Zhongguo Zhong Yao Za Zhi ; 44(18): 3895-3898, 2019 Sep.
Artículo en Chino | MEDLINE | ID: mdl-31872721

RESUMEN

The application of classical formula in the treatment of diabetes has a long history. Zhang Zhongjing set up a special chapter on consumptive thirst in Synopsis of the Golden Chamber,listing Baihu Jia Renshen Decoction for exuberant heat in the lung and stomach,dual deficiency of Qi and Yin syndrome,and Shenqi Pills for kidney Qi deficiency syndrome. However,the clinical application is not limited to them. In this study,formulas of Huanglian,Dahuang,Chaihu,Gualougen,Lingzhu,Huangqi and Dihuang are listed as the main therapeutic methods for diabetes mellitus,with effects in clearing heat,dredging the bowels and purging turbid,clearing depression and dispersing knots,nourishing Yin and quenching thirst,invigorating spleen and draining dampness,supplementing Qi and tonifying deficiency,nourishing Yin and tonifying kidney,which have the advantages for the treatment of diabetes and its complications. Based on accurate differentiation of symptoms and signs,consideration shall be given to both " of diseases and syndromes",while emphasis shall be given to the " main symptoms",so as to flexibly apply classical formula and expand the scope of application.


Asunto(s)
Diabetes Mellitus/tratamiento farmacológico , Medicamentos Herbarios Chinos/uso terapéutico , Humanos , Riñón , Pulmón , Medicina China Tradicional , Fitoterapia
13.
Ned Tijdschr Tandheelkd ; 126(12): 653-656, 2019 Dec.
Artículo en Holandés | MEDLINE | ID: mdl-31840676

RESUMEN

Scientific literature demonstrates relationships to exist between oral health and general health in a number of areas. A healthy oral cavity contributes to general wellbeing, but poor oral health can increase the risk of physical disorders, such as aspiration pneumonia, cardiovascular disorders, diabetes mellitus, and other disorders. Given the risks of these systemic diseases for frail older people, adequate and high-quality oral care is of great importance for this patient group.


Asunto(s)
Diabetes Mellitus , Neumonía por Aspiración , Anciano , Anciano de 80 o más Años , Anciano Frágil , Estado de Salud , Humanos , Boca , Salud Bucal
14.
JAMA ; 322(24): 2389-2398, 2019 12 24.
Artículo en Inglés | MEDLINE | ID: mdl-31860047

RESUMEN

Importance: The prevalence of diabetes among Hispanic and Asian American subpopulations in the United States is unknown. Objective: To estimate racial/ethnic differences in the prevalence of diabetes among US adults 20 years or older by major race/ethnicity groups and selected Hispanic and non-Hispanic Asian subpopulations. Design, Setting, and Participants: National Health and Nutrition Examination Surveys, 2011-2016, cross-sectional samples representing the noninstitutionalized, civilian, US population. The sample included adults 20 years or older who had self-reported diagnosed diabetes during the interview or measurements of hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and 2-hour plasma glucose (2hPG). Exposures: Race/ethnicity groups: non-Hispanic white, non-Hispanic black, Hispanic and Hispanic subgroups (Mexican, Puerto Rican, Cuban/Dominican, Central American, and South American), non-Hispanic Asian and non-Hispanic Asian subgroups (East, South, and Southeast Asian), and non-Hispanic other. Main Outcomes and Measures: Diagnosed diabetes was based on self-reported prior diagnosis. Undiagnosed diabetes was defined as HbA1c 6.5% or greater, FPG 126 mg/dL or greater, or 2hPG 200 mg/dL or greater in participants without diagnosed diabetes. Total diabetes was defined as diagnosed or undiagnosed diabetes. Results: The study sample included 7575 US adults (mean age, 47.5 years; 52% women; 2866 [65%] non-Hispanic white, 1636 [11%] non-Hispanic black, 1952 [15%] Hispanic, 909 [6%] non-Hispanic Asian, and 212 [3%] non-Hispanic other). A total of 2266 individuals had diagnosed diabetes; 377 had undiagnosed diabetes. Weighted age- and sex-adjusted prevalence of total diabetes was 12.1% (95% CI, 11.0%-13.4%) for non-Hispanic white, 20.4% (95% CI, 18.8%-22.1%) for non-Hispanic black, 22.1% (95% CI, 19.6%-24.7%) for Hispanic, and 19.1% (95% CI, 16.0%-22.1%) for non-Hispanic Asian adults (overall P < .001). Among Hispanic adults, the prevalence of total diabetes was 24.6% (95% CI, 21.6%-27.6%) for Mexican, 21.7% (95% CI, 14.6%-28.8%) for Puerto Rican, 20.5% (95% CI, 13.7%-27.3%) for Cuban/Dominican, 19.3% (95% CI, 12.4%-26.1%) for Central American, and 12.3% (95% CI, 8.5%-16.2%) for South American subgroups (overall P < .001). Among non-Hispanic Asian adults, the prevalence of total diabetes was 14.0% (95% CI, 9.5%-18.4%) for East Asian, 23.3% (95% CI, 15.6%-30.9%) for South Asian, and 22.4% (95% CI, 15.9%-28.9%) for Southeast Asian subgroups (overall P = .02). The prevalence of undiagnosed diabetes was 3.9% (95% CI, 3.0%-4.8%) for non-Hispanic white, 5.2% (95% CI, 3.9%-6.4%) for non-Hispanic black, 7.5% (95% CI, 5.9%-9.1%) for Hispanic, and 7.5% (95% CI, 4.9%-10.0%) for non-Hispanic Asian adults (overall P < .001). Conclusions and Relevance: In this nationally representative survey of US adults from 2011 to 2016, the prevalence of diabetes and undiagnosed diabetes varied by race/ethnicity and among subgroups identified within the Hispanic and non-Hispanic Asian populations.


Asunto(s)
Grupos de Población Continentales/estadística & datos numéricos , Diabetes Mellitus/etnología , Grupos Étnicos/estadística & datos numéricos , Adulto , Americanos Asiáticos , Estudios Transversales , Femenino , Hispanoamericanos , Humanos , Masculino , Encuestas Nutricionales , Prevalencia , Factores Socioeconómicos , Estados Unidos/epidemiología
15.
Nephrol Nurs J ; 46(6): 629-640, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31872993

RESUMEN

Reducing the growing burden of acute kidney injury (AKI) is a real challenge. This article explores admissions and emergency visits of patients with AKI in California between 2005 and 2015. Data were drawn from California's Office of Statewide Health Planning and Development (OSHPD) hospital dataset. Trend analyses, including comorbidities and spatiotemporal analysis, were conducted. AKI hospital episodes almost doubled between 2005 and 2015 (25,495 vs. 48,845, respectively); the growing trend was largely attributable to an increasing number of patients with co-existing CKD and diabetes or hypertension (2,511 vs. 25,098 in 2005 and 2015, respectively). We also found an increasingly positive spatiotemporal correlation between diabetes prevalence and AKI hospitalization rate over time. Based on results of this study, we identified modifiable targets to reduce the growing number of AKI episodes and the potential escalating health care costs.


Asunto(s)
Lesión Renal Aguda , Complicaciones de la Diabetes , Diabetes Mellitus , Hospitalización , Lesión Renal Aguda/complicaciones , Lesión Renal Aguda/epidemiología , California/epidemiología , Complicaciones de la Diabetes/epidemiología , Hospitalización/estadística & datos numéricos , Humanos , Estudios Retrospectivos , Factores de Riesgo
16.
Wei Sheng Yan Jiu ; 48(6): 945-952, 2019 Nov.
Artículo en Chino | MEDLINE | ID: mdl-31875820

RESUMEN

OBJECTIVE: To understand the epidemiological characteristics and risk factors of dyslipidemia in adult residents of Jiangsu Province in 2014. METHODS: A total of 8677 permanent residents over 18 years old were selected from 12 monitoring sites in Jiangsu Province in 2014 by multi-stage stratified cluster random sampling and were enrolled for questionnaire survey, physic examination and biochemical tests. RESULTS: Totally, 8299 cases were analyzed including 3732 males(45. 0%) and 4567 females(55. 0%). The rate of dyslipidemia was 38. 2%(standardized prevalence rate was38. 5%). Among the 8299 cases, 25. 8% had high TG(standardized rate was 25. 9%), 13. 2% had low HDL-C(standardized rate was 13. 4%), 6. 0% had high TC(standardized rate was 5. 9%). With the increase of age, the prevalence of dyslipidemia in males showed a downward trend(P<0. 05), and the dyslipidemia in females showed an increasing trend(P<0. 05). The prevalence of dyslipidemia in urban and rural adults was42. 9% and 36. 9%. The Logistic multivariate analysis showed that heavy physical and other types of labor were protective factors for dyslipidemia(OR = 0. 422 and 0. 749). Primary school education or above, occupational labor of medium type, overweight and obesity, central obesity were risk factors for dyslipidemia. Hypertension, diabetes, stroke were positively correlated with dyslipidemia(OR = 1. 045, 1. 927, 1. 927 and 1. 501). CONCLUSION: The prevalence of dyslipidemia in adults in Jiangsu Province is on the rise. Hyperlipidemia and low HDL-C are the main forms of dyslipidemia in Jiangsu Province.


Asunto(s)
Diabetes Mellitus , Dislipidemias , Adolescente , Adulto , China , Femenino , Humanos , Masculino , Obesidad , Sobrepeso , Prevalencia , Factores de Riesgo , Adulto Joven
17.
Zhongguo Zhong Yao Za Zhi ; 44(20): 4519-4528, 2019 Oct.
Artículo en Chino | MEDLINE | ID: mdl-31872641

RESUMEN

This study was aimed to investigate the mechanism of Danzhi Jiangtang Capsules( DJC) in the treatment of diabetic macrovascular disease in Goto-Kakizaki( GK) rats. The diabetic macrovascular disease rat model was induced by feeding high-fat and high-sugar combined with endothelial nitric oxide synthase( NOS) inhibitor N-nitro-L-arginine methyl ester( L-NAME)( 0. 1 g·L-1·d-1). According to the random array table,the model rats were randomly divided into the model group,DJC groups( 1 260,630,320 mg·kg-1),atorvastatin group( 105 mg·kg-1) and metformin group( 10 mg·kg-1),with 12 rats in each group. The rats received gavage administration for 8 weeks. Twelve Wistar rats were selected as the normal control group. The changes of body weight,water intake,blood glucose,plasma total cholesterol( TC),triglyceride( TG),high density lipoprotein( HDL-C),low density lipoprotein( LDL-C),interleukin( IL-1ß),IL-6,tumor necrosis factor( TNF-α),nitric oxide( NO),endothelin( ET-1) were observed in these rats. Aortic tissue was taken and the pathological changes were observed by HE staining. RT-PCR was used to detect the mRNA levels of IL-1ß,IL-6,and TNF-α in rat aorta. RT-PCR of the stem loop was used to detect the levels of miRNA-126,miRNA-155,miRNA-146 a,and miRNA-21 in rat plasma and aortic tissue. The canonical correlation between miRNAs and inflammatory factors was then analyzed. The results showed that DJC increased the rat body weight,lowered water intake,reduced the random blood glucose,reversed the rat aorta tissue damage,reduced serum TC,TG,LDL-C,ET-1,IL-1ß,IL-6,TNF-α,as well as miRNA-155,miRNA-146 a and miRNA-21 levels in serum,elevated plasma HDL-C,NO content,reduced the aorta mRNA of IL-1ß,IL-6,TNF-α,and the miRNA-155,miRNA-146 a and miRNA-21,elevated miRNA-126 expression in aorta. Aortic miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 expression levels were typically correlated with the expression of inflammatory factors,among which miRNA-126 was negatively correlated,miRNA-155,miRNA-146 a and miRNA-21 were positively correlated with the factors. These results suggested that DJC had therapeutic effects on diabetic macrovascular diseases,and the mechanism of action may be related to the regulation of miRNA-126,miRNA-155,miRNA-146 a and miRNA-21 levels,as well as the reduction of inflammatory factors and vascular inflammatory response.


Asunto(s)
Diabetes Mellitus , Medicamentos Herbarios Chinos/farmacología , MicroARNs , Animales , Cápsulas , Medicamentos Herbarios Chinos/uso terapéutico , Ratas , Ratas Wistar
18.
Sheng Li Xue Bao ; 71(6): 917-934, 2019 Dec 25.
Artículo en Chino | MEDLINE | ID: mdl-31879747

RESUMEN

Exosome is a kind of nanoscale-size extracellular vesicles secreted by the means of cell active stimulation with outer membrane structure of vacuoles corpuscle. It can carry and transfer a lot of biological molecules, such as DNA fragments, circular RNA (circRNA), messenger RNA (mRNA), microRNA (miRNA), functional proteins, transcription factors, etc., so as to achieve the goal of information transmission between cells. The relationship between exosomes and diabetes has received extensive attention in recent years. The exosomes play an important role in insulin sensitivity, glucose homeostasis and vascular endothelial function. This paper reviews the role of exosomes in the occurrence and development of diabetes and its complications, and discusses the role and prospect of exosomes as a target for diabetes treatment and its role in the diagnosis and treatment of diabetes.


Asunto(s)
Diabetes Mellitus , Exosomas , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/fisiopatología , Diabetes Mellitus/terapia , Exosomas/metabolismo , Humanos , Resistencia a la Insulina/fisiología , MicroARNs/metabolismo , ARN Mensajero/metabolismo
20.
Rev. salud pública Parag ; 9(2): [P9-P15], Dic 2019.
Artículo en Español | LILACS, BDNPAR | ID: biblio-1047044

RESUMEN

Introducción: La Diabetes Mellitus tipo 2 es una enfermedad metabólica muy frecuente, siendo una de las principales causas de mortalidad en nuestro país. El enfoque integral, individual, familiar y comunitario de la Atención Primaria de Salud a través de las Unidades de Salud de la Familia permite identificar síntomas de depresión que pueden aparecer durante el curso de la enfermedad. Objetivo: Determinar los niveles de depresión según la cronicidad de la Diabetes Mellitus tipo 2 y sus comorbilidades en pacientes de las Unidades de Salud del distrito de Encarnación en el año 2018. Metodología: Estudio con diseño observacional, analítico de corte transversal sobre 228 pacientes con Diabetes Mellitus tipo 2 entrevistados durante el año 2018. Se aplicó un formulario validado con el test de Kuder- Richardson y la Escala de Hamilton para la depresión. Los datos fueron procesados en EpiInfo v. 7. Resultados: Se detectó depresión en el 66,7 % (152) de las personas incluidas en el estudio, siendo más frecuente la depresión ligera presente en el 32, 9 % (75) de los casos, seguido de depresión moderada y grave. Se encontró asociación estadísticamente significativa entre depresión y años de evolución de Diabetes Mellitus tipo 2 (p = 0.029), hipertensión (p = 0.0024); neuropatía (p = 0.0003). Conclusión: El nivel de depresión más frecuente fue la ligera y la presencia de síntomas de depresión en pacientes con Diabetes Mellitus tipo 2 fue alta, asociada significativamente con años de evolución de la diabetes, hipertensión y neuropatía. Palabras clave: Diabetes mellitus, Depresión, Atención Primaria de Salud.


Introduction: Type 2 Diabetes Mellitus is a very frequent metabolic disease, being one of the main causes of mortality in our country. The integral, individual, family and community approach of Primary Health Care through the Family Health Units allows to identify symptoms of depression that may appear during the course of the disease. Objective: To determine the levels of depression according to the chronicity of Type 2 Diabetes Mellitus and its comorbidities in patients of the Health Units of the district of Encarnación in the year 2018. Methodology: Study with observational, analytical cross-sectional design on 228 patients with Type 2 Diabetes Mellitus interviewed during 2018. A validated form was applied with the Kuder-Richardson test and the Hamilton Scale for depression. The data was processed in EpiInfo v. 7. Results: Depression was detected in 66.7% (152) of the people included in the study, with mild depression being more frequent in 32.9% (75) of the cases, followed by moderate and severe depression. A statistically significant association was found between depression and years of evolution of Type 2 Diabetes Mellitus (p = 0.029), hypertension (p = 0.0024); neuropathy (p = 0.0003). Conclusion: The most frequent level of depression was mild and the presence of depression symptoms in patients with Type 2 Diabetes Mellitus was high, significantly associated with years of evolution of diabetes, hypertension and neuropathy. Keywords: Diabetes mellitus, Depression, Primary Health Care.


Asunto(s)
Humanos , Masculino , Femenino , Atención Primaria de Salud , Depresión , Diabetes Mellitus/psicología , Enfermedad Crónica/psicología
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