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1.
Dental Press J Orthod ; 27(1): e22spe1, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35674572

RESUMO

INTRODUCTION: There are different possibilities of orthodontic planning for cases with congenital absence of maxillary lateral incisors. This subject divides the opinion of orthodontists and oral rehabilitation clinicians, due to the advantages and disadvantages of each treatment option, which may involve opening spaces for future implants and/or prosthetic restorations, or closing the spaces by positioning the maxillary canines in the place of lateral incisors. The correct diagnosis and careful evaluation of each patient allow to determine the best therapeutic approach. This paper discusses the main topics to be considered when planning these cases. OBJECTIVES: To evaluate the main aspects related to orthodontic treatment planning in cases of congenital absence of maxillary lateral incisors, to aid the decision-making, with clinical and scientific basis.


Assuntos
Anodontia , Incisivo , Anodontia/diagnóstico , Anodontia/terapia , Dente Canino , Estética Dentária , Humanos , Incisivo/anormalidades , Má Oclusão , Maxila
2.
Biomed Res Int ; 2022: 6217399, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35647187

RESUMO

Due to the complexity of clinical manifestations and the lack of standardized diagnostic criteria, it is still difficult to distinguish the etiological types of congenital edentulousness corresponding to genetic defects. This paper studies the application of deep learning image processing and digital image processing in medical images in detail and analyzes the functions of congenital edentulous hotspot genes. The cases in the control group and the study group were collected, and the gene mutations of direct sequence MSX1, PAX9, AXIN2, and BMP were analyzed, and new pathogens were found. The experimental results suggest that PAX9 and MSX1 genes may have a synergistic effect in nonsyndromic congenital edentulous patients. In severely missing teeth, the role of PAX9 may be greater than that of MSX1. The experimental results will help us lay the foundation for further understanding of the disease in the future.


Assuntos
Anodontia , Anormalidades Maxilomandibulares , Anodontia/diagnóstico por imagem , Anodontia/genética , Proteína Axina/genética , Proteínas Morfogenéticas Ósseas/genética , Humanos , Fator de Transcrição MSX1/genética , Mutação , Fator de Transcrição PAX9/genética
3.
PLoS One ; 17(6): e0269934, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35687588

RESUMO

Periodontitis is greatly related to worse perceived oral health-related quality of life (OHRQoL), yet this association has never been explored using radiographically screened periodontal bone loss. Here we have radiographically screened patients for periodontitis via a validated method and assessed its association with measures of OHRQoL. From a total of 10,267 participants (6,112 females and 4,155 males), self-reported general health questionnaire, body mass index, self-reported oral health behaviours, panoramic x-rays and the oral health impact profile (OHIP-14) were gathered. Radiographically screened periodontitis was measured through a radiographic-based periodontal bone loss (R-PBL) approach. We compared the respective variables according to the R-PBL status and explored using multiple logistic regression adjusted for the significant variables. Overall, patients with periodontitis shown significantly different sociodemographic, health measures and oral hygiene characteristics. All domains of the OHIP-14 were significantly worsened in the periodontitis group, and further confirmed through adjusted logistic regression (p<0.001). Active smoking, number of missing teeth, sex and age were the most impactful variables in this relationship. Our results demonstrate the existence of a link between radiographically screened periodontitis and OHRQoL, mostly upheld by active smoking, number of missing teeth, sex and age.


Assuntos
Perda do Osso Alveolar , Anodontia , Periodontite , Perda de Dente , Perda do Osso Alveolar/diagnóstico por imagem , Estudos Transversais , Feminino , Humanos , Masculino , Saúde Bucal , Periodontite/diagnóstico por imagem , Periodontite/epidemiologia , Qualidade de Vida , Inquéritos e Questionários
4.
Eur J Paediatr Dent ; 23(2): 131-136, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35722839

RESUMO

AIM: To investigate the effects of anticancer therapy on dental development and caries formation in Italian childhood cancer survivors compared to healthy controls. METHODS: A total of 52 children treated with chemotherapy and/or radiotherapy when younger than 10 years and in remission from at least 2 years, and 52 healthy age- and gender-matched children were consecutively enrolled in this cross-sectional study. All participants were examined for dental caries and enamel defects according to the decayed-missing-filled teeth (dmft/DMFT) index and the Aine rating scale. Panoramic radiographs were taken to estimate dental age and to assess dental abnormalities using the Höltta Defect Index. CONCLUSION: These children are at high risk for tooth developmental abnormalities and poor dental health and should be closely monitored by a specialist dentist.


Assuntos
Anodontia , Cárie Dentária , Anormalidades Dentárias , Criança , Estudos Transversais , Índice CPO , Dentição , Humanos , Prevalência
5.
Eur J Paediatr Dent ; 23(2): 140-146, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35722846

RESUMO

AIM: Despite the fact that ectodermal dysplasia (ED) is a rare disease, it is often seen in a tertiary clinic. ED affects ectodermal tissues such as skin, hair, teeth, nails, and sweat glands. Patients usually have sparse light hair, deformed nails, and dry skin. They suffer from dental abnormalities such as oligodontia (absence of 6 or more teeth) or complete anodontia; salivation can also be affected. The absence of teeth can be the overriding problem for both patients and their parents, and lead to substantial social ostracisation. This study aims to summarise the facts about the disease, especially dental treatment options based on data drawn from a representative Czech cohort. MATERIALS: The present article summarises the facts about ectodermal dysplasia (ED) in a cohort of 13 patients, where the following were evaluated: clinical manifestations of ED, pathogenic variants detected in selected candidate genes and dental treatment options from child removable dentures to fixed crowns and implants insertion. Three cases are described in detail and demonstrate approaches for different age groups. CONCLUSION: Early diagnosis and active cooperation between the geneticist and dentist will facilitate cooperation with parents and patients and assure secondary prevention. It is preferable that the geneticist understands dental treatment options and can discuss these with patients/parents.


Assuntos
Anodontia , Displasia Ectodérmica , Anodontia/terapia , Criança , Assistência Odontológica , Displasia Ectodérmica/complicações , Displasia Ectodérmica/terapia , Humanos
6.
J Contemp Dent Pract ; 23(1): 95-99, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-35656665

RESUMO

AIM: To evaluate the awareness among the patients visiting a dental college in replacing the missing teeth. MATERIALS AND METHODS: A cross-sectional survey was conducted to know the patient's awareness and preference for the treatment options. A list of the closed-ended questionnaire was used to record the patient's response about being edentulous. The collected data were statistically analyzed. SPSS, Version 2.1, statistical software was used. The descriptive statistics were done using frequency and percentage. Bar graphs and pie graphs were used wherever applicable. RESULTS: Maximum patients reported to dental treatment with less than 1 year period of edentulousness. This directly indicates an increased awareness among the patients (77.5%). The need to replace the missing teeth was a function such as mastication of food for 42.6% of the patients and 36.6% of the patients wanted to replace their missing teeth for improving their appearance. The most preferred method of the replacement is fixed partial denture (FPD) as it was cost-effective and affordable for them. Only 22% of the patients wanted an implant as a treatment option as it did not involve the adjacent teeth. CONCLUSION: The awareness and knowledge about the treatment options among the patients visiting the dental college have increased, but still, the awareness about the consequences of being edentulous for a long time should be improved through social media by the dentists. CLINICAL SIGNIFICANCE: The replacement of missing teeth is important in rehabilitating the form, function, esthetics, and integrity of the stomatognathic system. There are various treatment options available for replacing missing teeth. Very few patients are aware of all the options and the consequences of not replacing the posterior teeth.


Assuntos
Anodontia , Boca Edêntula , Perda de Dente , Academias e Institutos , Estudos Transversais , Estética Dentária , Humanos
7.
PLoS One ; 17(5): e0269163, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35622841

RESUMO

Current knowledge of transitional care from the perspective of individuals with congenital malformations is scarce. Their viewpoints are required for the development of follow-up programs and transitional care corresponding to patients' needs. The study aimed to describe expectations, concerns, and experiences in conjunction with transfer to adult health care among adolescents, young adults, and adults with VACTERL association, (i.e. vertebral defects, anorectal malformations (ARM), cardiac defects (CHD), esophageal atresia (EA), renal, and limb abnormalities). Semi-structured telephone interviews were performed and analyzed with qualitative content analysis. Of 47 invited individuals, 22 participated (12 males and 10 females). An overarching theme emerged: Leaving the safe nest of pediatric health care for an unfamiliar and uncertain follow up yet growing in responsibility and appreciating the adult health care. The participants described expectations of qualified adult health care but also concerns about the process and transfer to an unfamiliar setting. Individuals who were transferred described implemented or absence of preparations. Positive and negative experiences of adult health care were recounted including being treated as adults. The informants described increasing involvement in health care but were still supported by their parents. Ongoing follow up of health conditions was recounted but also uncertainty around the continuation, missing follow up and limited knowledge of how to contact health care. The participants recommended information ahead of transfer and expressed wishes for continued health care with regular follow up and accessibility to a contact person. Based on the participants' perspective, a transitional plan is required including early information about transfer and follow up to prepare the adolescents and reduce uncertainty concerning future health care. Meetings with the pediatric and adult team together with the patient and the parents are essential before transfer. Follow up should be centralized to centers with multi-professional teams well-experienced with the condition. Further studies are warranted to evaluate the transition process for adolescents and young adults with complex congenital health conditions.


Assuntos
Deformidades Congênitas dos Membros , Transição para Assistência do Adulto , Adolescente , Canal Anal/anormalidades , Criança , Atenção à Saúde , Esôfago/anormalidades , Feminino , Cardiopatias Congênitas , Humanos , Rim/anormalidades , Deformidades Congênitas dos Membros/terapia , Masculino , Coluna Vertebral/anormalidades , Suécia , Traqueia/anormalidades , Adulto Jovem
8.
Int Orthod ; 20(2): 100635, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35562286

RESUMO

INTRODUCTION: Tooth autotransplantation is a viable surgical treatment option for patients with missing permanent teeth. Premolars are generally used for autotransplantation but often require extensive modifications. This case report evaluates the use of supernumerary tooth as an alternative option for premolar autotransplantation. This report shows successful supernumerary tooth autotransplantation with 6-year follow-up. METHODS: A 13-year-old male with non-contributory medical history was referred for a missing maxillary left central incisor (#9) and presence of a supernumerary tooth. The clinical and radiographic examination revealed presence of supernumerary tooth with similar dimensions to a central incisor. The treatment plan included autotransplantation of the supernumerary tooth to replace the missing central incisor (short-term) and future implant replacement of the autotransplanted tooth when jaw growth ceases (long-term). The patient and parents consented to treatment. A 3-D tooth replica was constructed based on CBCT analyses. Site #9 was prepared using split ridge technique to create a socket to house the 3-D replica. Upon achieving proper socket form, the supernumerary tooth was extracted and autotransplanted in the prepared socket. The supernumerary tooth was splinted, and the bite opened posteriorly using composite to eliminate any occlusal interferences. RESULTS: The patient was followed up clinically and radiographically. The autotransplanted supernumerary tooth integrated well within the newly created socket and remained functional at the 6-year follow-up. CONCLUSIONS: The current case presents successful management of supernumerary tooth autotransplantation with 6-year follow-up. The results show stable periodontium with satisfactory functional and aesthetic results.


Assuntos
Anodontia , Dente Supranumerário , Adolescente , Estética Dentária , Seguimentos , Humanos , Incisivo/diagnóstico por imagem , Incisivo/cirurgia , Masculino , Maxila/diagnóstico por imagem , Maxila/cirurgia , Dente Supranumerário/diagnóstico por imagem , Dente Supranumerário/cirurgia , Transplante Autólogo
9.
Int J Esthet Dent ; (2): 140-151, 2022 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-35586996

RESUMO

The replacement of a single tooth can be achieved through multiple restorative alternatives. Resin-bonded fixed restorations are the most conservative option if dental implant placement is not possible or is contraindicated. Over the years, an increase in knowledge and the improvement of materials and technologies have enriched many aspects of this technique. According to the literature, single-retainer all-ceramic cantilevered restorations made either from zirconia or lithium disilicate have shown long-term success. The present article describes the updated, scientifically validated protocols of this technique with a particular focus on framework design and adhesive procedures, including a clinical report with a 6-year recall of maxillary lateral incisor agenesia that was managed with a single-retainer lithium disilicate fixed restoration.


Assuntos
Porcelana Dentária , Zircônio , Cerâmica , Falha de Restauração Dentária , Humanos , Incisivo
10.
J Coll Physicians Surg Pak ; 32(5): 570-574, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35546689

RESUMO

OBJECTIVE: To discover novel ectodysplasin-A (EDA) and wingless-type MMTV integration site family, member 10A (WNT10A) mutations in tooth agenesis (TA) patients. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Guanghua School of Stomatology, Guangzhou, China, from March 2018 to August 2020. METHODOLOGY: EDA and WNT10A were analysed in eleven TA families by PCR and Sanger sequencing. Bioinformatics and structure modelling analyses were performed after identifying different variants, to predict the resulting conformational alterations in WNT10A and EDA. RESULTS:  Two novel mutations (c.796C>A (p.L266I), c.769G>A (p.G257R)) in EDA and two reported mutations (c.637G>A (p.G213S), c.511C>T (p.R171C))in WNT 10A were detected. Combined with the 3D structural analysis, we discovered a correlation between alterations in hydrogen bond formation and the observed phenotypes, potentially affecting protein binding. CONCLUSIONS: The mutations were predicted to be pathogenic through bioinformatics analyses. In addition, by identifying novel mutations, our knowledge regarding the TA spectrum and tooth development was considerably expanded. KEY WORDS:  Anodontia, EDA, WNT 10A, Whole exome sequencing, Odontogenesis.


Assuntos
Anodontia , Ectodisplasinas , Anodontia/genética , Ectodisplasinas/química , Ectodisplasinas/genética , Ectodisplasinas/metabolismo , Humanos , Mutação , Linhagem , Fenótipo , Sequenciamento Completo do Exoma
11.
Pediatr Rheumatol Online J ; 20(1): 24, 2022 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-35410415

RESUMO

BACKGROUND: Singleton-Merten syndrome 1 (SGMRT1) is a rare type I interferonopathy caused by heterozygous mutations in the IFIH1 gene. IFIH1 encodes the pattern recognition receptor MDA5 which senses viral dsRNA and activates antiviral type I interferon (IFN) signaling. In SGMRT1, IFIH1 mutations confer a gain-of-function which causes overactivation of type I interferon (IFN) signaling leading to autoinflammation. CASE PRESENTATION: We report the case of a nine year old child who initially presented with a slowly progressive decline of gross motor skill development and muscular weakness. At the age of five years, he developed osteoporosis, acro-osteolysis, alveolar bone loss and severe psoriasis. Whole exome sequencing revealed a pathogenic de novo IFIH1 mutation, confirming the diagnosis of SGMRT1. Consistent with constitutive type I interferon activation, patient blood cells exhibited a strong IFN signature as shown by marked up-regulation of IFN-stimulated genes. The patient was started on the Janus kinase (JAK) inhibitor, ruxolitinib, which inhibits signaling at the IFN-α/ß receptor. Within days of treatment, psoriatic skin lesions resolved completely and the IFN signature normalized. Therapeutic efficacy was sustained and over the course muscular weakness, osteopenia and growth also improved. CONCLUSIONS: JAK inhibition represents a valuable therapeutic option for patients with SGMRT1. Our findings also highlight the potential of a patient-tailored therapeutic approach based on pathogenetic insight.


Assuntos
Interferon Tipo I , Osteoporose , Doenças da Aorta , Criança , Pré-Escolar , Hipoplasia do Esmalte Dentário , Humanos , Helicase IFIH1 Induzida por Interferon/genética , Masculino , Metacarpo/anormalidades , Debilidade Muscular , Doenças Musculares , Nitrilas , Odontodisplasia , Osteoporose/genética , Pirazóis , Pirimidinas , Calcificação Vascular
13.
Rev. Odontol. Araçatuba (Online) ; 43(1): 57-61, jan.-abr. 2022. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1361720

RESUMO

A agenesia dentaria é uma anomalia de desenvolvimento caracterizada pela determinação congênita de menor numero de dentes, podendo estar associada a síndromes genéticas ou ocorrer isoladamente. Embora seja considerada uma das anomalias mais frequentes quando envolve terceiros molares, segundo pré-molares e incisivos laterais, sua ocorrência em dentes estáveis, tais como o canino e o primeiro molar permanente é rara. Desta forma, este relato apresentará o caso de uma paciente do sexo feminino, 8 anos idade, que iniciou tratamento de rotina na Clínica de Odontopediatria da UNIFENAS. Na anamnese não foi relatada pela responsável a ocorrência de alterações sistêmicas, nem queixa ou histórico odontológico relevante. No exame clínico odontológico, notou-se o não irrompimento do primeiro molar permanente superior direito (16). Diante dos exames de imagem, foi confirmada a agenesia do dente 16 e também do canino permanente superior direito (13). A agenesia, sobretudo de dentes estáveis e relevantes no arco dentário, pode comprometer o desenvolvimento adequado da oclusão, mastigação, fonação e estética. Desta maneira, é importante o diagnóstico precoce desta ocorrência com o objetivo de favorecer a elaboração de um adequado plano de tratamento e, minimizar as sequelas destas agenesias atípicas(AU)


Dental agenesis is a developmental anomaly characterized by the congenital determination of fewer teeth, may be associated with genetic syndromes or occur in an isolated form. Although it is considered one of the most frequent anomalies when it involves third molars, second lateral premolars and incisors, the occurrence in stable teeth, such as the permanent canine and the permanent first molar is rare. This report will present the case of an 8-year-old female patient who started routine treatment at the Pediatric Dentistry Clinic of UNIFENAS. In the anamnesis, the responsible person did not report the occurrence of systemic alterations, or a relevant dental complaint or history. On dental clinical examination, it was noticed the non-rupture of the permament maxillar right first molar (16). In view of the imaging tests, the agenesis of tooth 16 and also of the permanent maxillary right canine (13) was confirmed. Agenesis, especially of stable and relevant teeth in the dental arch, may compromise the proper development of occlusion, chewing, phonation and aesthetics. Thus, it is of paramount importance to early diagnosis of this occurrence in order to favor the development of an appropriate treatment plan in order to minimize the sequelae of these atypical agenesis(AU)


Assuntos
Humanos , Masculino , Criança , Fonação , Dente Canino , Anodontia , Dente Molar , Oclusão Dentária , Estética Dentária , Mastigação , Anodontia/diagnóstico , Anodontia/terapia
14.
Int J Implant Dent ; 8(1): 19, 2022 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-35428947

RESUMO

PURPOSE: Tooth extraction and the projection of the tooth roots into the maxillary sinus are reported to greatly reduce the bone height from the alveolar ridge to the maxillary sinus floor, while missing teeth are reported to lead to the expansion of the maxillary sinus, all of which are important considerations during dental implant treatment for the maxillary molar region. Therefore, assessing the anatomical characteristics of the maxillary sinus acting as complicating factors is crucial before sinus augmentation. We conducted a three-dimensional examination of the effects of missing teeth and nasal septal deviation (NSD) on maxillary sinus volume (MSV). METHODS: We selected participants with two or more missing teeth from patients who underwent maxillary sinus augmentation for a unilateral free-end saddle between April 2019 and December 2020. We calculated the MSV and NSD using cone-beam computed tomography (CBCT). We compared the relationships of the presence/absence of teeth and NSD with MSV bilaterally in each patient using the Wilcoxon t-test. p-values < 0.05 denoted statistical significance. RESULTS: This study included 30 patients (30 sinuses; 12 men, 18 women). The average patient age was 58.2 ± 10.2 years (men, 60.4 ± 3.7 years; women, 59.2 ± 4.5 years; range, 40-77 years). The mean number of missing teeth was 2.98 ± 1.01: 13 patients had two missing teeth and 17 had three or more missing teeth. Nine patients (30%) had NSD. The mean MSV on the ipsilateral and contralateral sides of the NSD was 21.50 ± 3.84 cm3 and 22.10 ± 3.56 cm3, respectively; thus, NSD did not affect MSV (p = 0.150). The mean MSV on the edentulous and non-edentulous sides was 21.58 ± 3.89 cm3 and 21.77 ± 4.30 cm3, respectively; thus, the MSV was significantly smaller on the edentulous side (p = 0.00036). CONCLUSION: Although this study was a limited preoperative study, three-dimensional measurement of the maxillary sinus with CBCT in partially edentulous patients revealed that missing teeth lead to substantial reductions in MSV, while NSD was not associated with MSV.


Assuntos
Anodontia , Boca Edêntula , Levantamento do Assoalho do Seio Maxilar , Perda de Dente , Adulto , Idoso , Tomografia Computadorizada de Feixe Cônico/métodos , Feminino , Humanos , Masculino , Seio Maxilar/diagnóstico por imagem , Pessoa de Meia-Idade , Projetos Piloto
15.
Med Anthropol ; 41(4): 446-459, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35394900

RESUMO

While recent decades have seen a rapid rise in cases of infant tongue-tie and in surgery to correct it, a controversy is now raging over the condition. Opinion is especially divided over so-called posterior tongue-tie, a variant which is detected based on the "feel" of the sub-lingual space. Drawing on ethnographic research with clinicians in England, we clarify the professional and personal commitments involved in the controversy. Our analysis is informed by Douglas' theory of cultural representations (grid-group theory), in which ideas of what is natural and unnatural constitute central metaphors.


Assuntos
Anquiloglossia , Freio Lingual/anormalidades , Língua/anormalidades , Anquiloglossia/etnologia , Anquiloglossia/cirurgia , Antropologia Cultural , Antropologia Médica , Aleitamento Materno , Atenção à Saúde , Inglaterra , Feminino , Humanos , Lactente , Freio Lingual/cirurgia , Língua/cirurgia
16.
Sci Rep ; 12(1): 4485, 2022 03 16.
Artigo em Inglês | MEDLINE | ID: mdl-35296697

RESUMO

Survival following childhood cancer has increased considerably. In an observational cross-sectional study, we assessed the prevalence of dental developmental anomalies (DDA) among childhood cancer survivors according to types of anticancer treatment. Permanent teeth were examined clinically and radiographically in 121 adolescents with a history of childhood malignancies, to identify DDA, namely hypomineralization or hypoplasia, microdontia, root changes and hypodontia. DDA were observed in 56/121 individuals (46%), in 309/3388 teeth (9%). Hypomineralization or hypoplasia of enamel appeared in 21 (17%) patients. Altered root development appeared in 26 patients and hypodontia affected 13 (10%). Dental anomalies were observed in 36 (43%) individuals who received chemotherapy and not radiation, in 20 (52%) who received radiotherapy, and in 15 (60%) of those who received head and neck radiotherapy. Among patients who received only chemotherapy, young age (6 years or younger) was associated with a higher number of malformed teeth. In conclusion, antineoplastic treatment that combines chemotherapy and radiotherapy appears to increase the risk of DDA. Radiation to the head and neck area was shown to particularly increase the risk of DDA. No specific chemotherapy agent was found to be associated more than the others with DDA.


Assuntos
Anodontia , Antineoplásicos , Sobreviventes de Câncer , Neoplasias , Anormalidades Dentárias , Adolescente , Antineoplásicos/efeitos adversos , Criança , Estudos Transversais , Humanos , Neoplasias/induzido quimicamente , Neoplasias/tratamento farmacológico , Neoplasias/epidemiologia , Prevalência , Anormalidades Dentárias/epidemiologia , Anormalidades Dentárias/etiologia
17.
Eur Endod J ; 7(1): 73-80, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35353060

RESUMO

Dens invaginatus (DI) is one of the most common developmental anomalies observed in maxillary lateral incisors. An early diagnosis requires thorough clinical knowledge, advanced radiographic evaluation as well as the use of cone beam computed tomography (CBCT) and dental operating microscope (DOM), dictates the successful endodontic management of such teeth. A total of 7 cases with (DI) in maxillary lateral incisors were collected from dental practitioners worldwide, analysed and reported in the present case series. Our aim was to analyse and understand the various morphological patterns of DI in maxillary lateral incisors with their varied treatment protocols employed worldwide. This article illustrates the aberrant morphological patterns and the diverse treatment protocols followed by the clinicians worldwide. The use of biomaterials enhances post-operative healing. Further, a modification in the existing classification has been proposed in this report which would enable the clinicians to easily diagnose, categorise and effectively manage DI. The different treatment protocols employed for the management of DI has been discussed and the use of CBCT and DOM in identifying and managing the anatomical variation of DI were emphasised.


Assuntos
Dens in Dente , Tomografia Computadorizada de Feixe Cônico/métodos , Dens in Dente/diagnóstico por imagem , Dens in Dente/terapia , Odontólogos , Humanos , Incisivo/anormalidades , Incisivo/diagnóstico por imagem , Papel Profissional
18.
Sci Rep ; 12(1): 5009, 2022 03 23.
Artigo em Inglês | MEDLINE | ID: mdl-35322150

RESUMO

Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a receptor for SVA in pigs was investigated by CRISPR/Cas9 genome editing. Strikingly, ANTXR1 knockout (KO) pigs exhibited features consistent with the rare disease, GAPO syndrome, in humans. Fibroblasts from wild type (WT) pigs supported replication of SVA; whereas, fibroblasts from KO pigs were resistant to infection. During an SVA challenge, clinical symptoms, including vesicular lesions, and circulating viremia were present in infected WT pigs but were absent in KO pigs. Additional ANTXR1-edited piglets were generated that were homozygous for an in-frame (IF) mutation. While IF pigs presented a GAPO phenotype similar to the KO pigs, fibroblasts showed mild infection, and circulating SVA nucleic acid was decreased in IF compared to WT pigs. Thus, this new ANTXR1 mutation resulted in decreased permissiveness of SVA in pigs. Overall, genetic disruption of ANTXR1 in pigs provides a unique model for GAPO syndrome and prevents circulating SVA infection and clinical symptoms, confirming that ANTXR1 acts as a receptor for the virus.


Assuntos
Infecções por Picornaviridae , Picornaviridae , Doenças dos Suínos , Alopecia , Animais , Anodontia , Transtornos do Crescimento , Atrofias Ópticas Hereditárias , Fenótipo , Picornaviridae/genética , Doenças Raras , Receptores de Peptídeos , Suínos
19.
J Dent Child (Chic) ; 89(1): 36-40, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35337398

RESUMO

Hypodontia is commonly associated with cleft lip and/or palate and can be managed by autotransplantation of teeth. In this case report, autotransplantation of the immature mandibular right second premolar to replace the congenitally missing maxillary right second premolar was performed successfully in an 11-year-old Chinese male. An ectopic tooth resembling a premolar tooth was subsequently noted to be developing palatal to the root apex of the transplanted tooth one month after surgery. The development of a dental tooth germ at the site of the autotransplantation post-surgery is a possibility and clinicians should be aware and monitor for such development. The development of a tooth germ post-autotransplantation of an immature tooth could provide a new perspective into tooth organogenesis in patients with agenesis of permanent teeth.


Assuntos
Anodontia , Fenda Labial , Fissura Palatina , Anodontia/complicações , Anodontia/cirurgia , Criança , Fenda Labial/complicações , Fissura Palatina/complicações , Humanos , Masculino , Germe de Dente , Transplante Autólogo
20.
J Dent Child (Chic) ; 89(1): 29-35, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-35337397

RESUMO

Molar-incisor malformation (MIM) is a newly described dental developmental anomaly that predominantly affects primary second molars, permanent first molars, and, in some cases, permanent central incisors. Diagnosis is usually made upon radiographic examination. The molars usually present with significant cervical constriction, flattened pulp chambers, and absent or thin, short, and narrow roots, whereas the incisors usually exhibit coronal dilaceration. Loss of these compromised teeth in the long term may be inevitable. Thus, clinicians should be aware of this condition and the factors to consider to advise their patients as early as possible. The purpose of this paper is to present two cases of MIM and discuss the factors clinicians should take into consideration to make a care plan in these cases.


Assuntos
Incisivo , Anormalidades Dentárias , Cavidade Pulpar , Humanos , Incisivo/anormalidades , Incisivo/diagnóstico por imagem , Incisivo/cirurgia , Dente Molar/anormalidades , Dente Molar/diagnóstico por imagem , Dente Molar/cirurgia , Radiografia Panorâmica
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