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1.
Rev. cuba. angiol. cir. vasc ; 20(2)jul.-dic. 2019. tab
Artigo em Espanhol | LILACS | ID: biblio-1003857

RESUMO

Introducción: El pie diabético isquémico y la enfermedad arterial periférica, son dos enfermedades que ocasionan dolor por isquemia crítica y ponen en peligro la viabilidad de las extremidades inferiores. Objetivo: Demostrar la efectividad de la terapia regenerativa con plasma rico en plaquetas en pacientes con las enfermedades citadas. Métodos: Estudio longitudinal, prospectivo y aleatorizado realizado en el Servicio de Angiología del Hospital: Julio Trigo López, entre enero 2016-diciembre 2017. Se incluyeron 26 pacientes en dos grupos de estudios, 10 pacientes no diabéticos con claudicación intermitente y 16 pacientes con lesiones isquémicas en el pie del diabético. Se aplicó plasma rico en plaquetas por vía intramuscular en la pierna afectada, en el primer grupo y de forma intra- y perilesional en el pie del diabético isquémico. Resultados: Se obtuvo alivio del dolor y mejoría en más del 70 por ciento de los pacientes en la distancia de claudicación por encima o cerca de los 200 metros. En los pacientes con pie diabético isquémico, alivio del dolor y cierre de las lesiones isquémicas en el 81,3 por ciento, solo 3 pacientes requirieron amputaciones mayores de los miembros inferiores. Conclusiones: La terapia regenerativa resulta efectiva en el salvataje de las extremidades inferiores en los pacientes estudiados, asociada a los procedimientos convencionales empleados en la cirugía revascularizadora; disminuye la amputación mayor de miembros inferiores y es una posibilidad terapéutica más en manos de especialistas entrenados, por su impacto social y en la calidad de vida de pacientes y familiares(AU)


Introduction: Ischemic diabetic foot and peripheral arterial disease are two conditions that cause pain and put in danger the functionality of lower limbs. Objective: To demonstrate the effectiveness of regenerative therapy with platelet-rich plasma in patients with the above mentioned diseases. Methods: Longitudinal, prospective and randomized study that was conducted in the Angiology Service of Julio Trigo López Hospital, from January 2016 to December 2017. There were 26 patients included in 2 groups: 10 non-diabetic patients with intermittent claudication and 16 patients with ischemic lesions in the diabetic foot. Platelet-rich plasma was used instramuscularly in an affected legs of the first group, and intraperilesional and perilesional in the diabetic foot. Results: There was pain relief and improvement in more than 70 percent of patients in the claudication distance higher or near to 200 meters. In the patients presenting ischemic diabetic foot, pain relief and closing of ischemic lesions in the 81,3 percent , just 3 patients required major amputations of lower limbs. Conclusions: Regenerative therapy results effective in the rescue of lower limbs in patients presenting peripheral arterial disease and ischemic diabetic foot. It also reduces major amputations of lower limbs and it is another therapeutic option in the hands of trained specialists due to its social impact and in the life quality of patients and their families(AU)


Assuntos
Humanos , Masculino , Feminino , Plasma Rico em Plaquetas , Doença Arterial Periférica/terapia , Proloterapia/métodos , Estudos Prospectivos , Estudos Longitudinais , Cuba
2.
Rev. cuba. angiol. cir. vasc ; 20(2): e387, jul.-dic. 2019.
Artigo em Espanhol | LILACS | ID: biblio-1003855

RESUMO

Introducción: Los pacientes con enfermedad arterial periférica sometidos a cirugía vascular no cardíaca programada presentan un riesgo significativo de complicaciones cardiovasculares, debido a la enfermedad cardíaca sintomática o asintomática subyacente. Objetivo: Valorar el riesgo coronario en los pacientes tributarios de cirugía vascular no cardíaca. Métodos: Estudio descriptivo prospectivo en 35 pacientes del Servicio de Angiología y Cirugía Vascular del Hospital Clínico Quirúrgico Hermanos Ameijeiras. El período de estudio osciló entre octubre de 2013 y mayo de 2016. Las variables cualitativas se expresaron como frecuencias absolutas y relativas. Se evaluó la asociación entre las variables mediante el test de Fischer, se usó el coeficiente de Pearson para relacionar los valores del índice de presiones tobillo brazo y los niveles del calcio score. Resultados: Predominó el sexo masculino y la edad menor de 60 años. El tabaquismo y la hipertensión arterial fueron los factores de riesgo de mayor frecuencia. A pesar de no existir diferencia significativa (p = 0,563) al asociar el calcio score y el índice de presiones tobillo-brazo, sí existió una correlación lineal negativa entre ellos. Las complicaciones perioperatorias presentadas en el grupo de moderado-alto riesgo quirúrgico fueron la fibrilación ventricular, el infarto agudo de miocardio y el paro cardíaco. Conclusiones: La valoración del riesgo coronario es una herramienta útil en la detección de lesiones coronarias significativas que pueden favorecer la aparición de complicaciones perioperatorias en los pacientes que son tributarios de tratamiento quirúrgico revascularizador no cardíaco(AU)


Introduction: Patients with peripheral arterial disease undergoing scheduled non-cardiac vascular surgery present a significant risk of cardiovascular complications due to underlying symptomatic or asymptomatic heart disease. Objective: To assess coronary risk in patients eligible for non-cardiac vascular surgery. Methods: A prospective descriptive study was carried out in 35 patients of the Angiology and Vascular Surgery service in Hermanos Ameijeiras Hospital. The study was conducted between October 2013 and May 2016. Qualitative variables were summarized as absolute and relative frequencies. It was assessed the association between the variables using the Fischer´s test; Pearson´s coefficient was used to relate the values of the index of ankle- arm pressure and the levels of calcium score. Results: Male sex predominated; and ages less than 60 years. Smoking habit and high blood pressure were the most common risk factors. Although there is no significant difference (p= 0,563) when associating the calcium score and the ankle-brachial pressure index, there was a negative linear correlation between them. The peri-operative complications presented in the moderate to high surgical risk group were ventricular fibrillation, acute myocardial infarction and cardiac arrest. Conclusions: Identification of coronary risk is a useful tool in the detection of significant coronary lesions that may favor the emergence of peri-operative complications in patients who are scheduled for non-cardiac revascularization's surgical treatment(AU)


Assuntos
Masculino , Pessoa de Meia-Idade , Doenças Cardiovasculares/prevenção & controle , Doença Arterial Periférica/complicações , Epidemiologia Descritiva , Estudos Prospectivos , Estudos Longitudinais , Doença Arterial Periférica/terapia
3.
Bol. venez. infectol ; 30(2): 116-121, jul-dic 2019.
Artigo em Espanhol | LILACS-Express | ID: biblio-1024096

RESUMO

El VIH/Sida sigue siendo uno de los mayores problemas de salud pública a nivel mundial, comparte mecanismo de transmisión con la sífilis, por lo que la coinfección puede ocurrir. Objetivo: Describir las características clínico-epidemiológicas, serológicas e inmunológicas de los pacientes con diagnóstico reciente de VIH/Sida coinfectados con sífilis. Metodología: Investigación clínica, descriptiva, transversal, retrospectiva, apoyada en una revisión bibliográfica. Se incluyeron pacientes mayores de 18 años atendidos en la Unidad de Infectología de la Ciudad Hospitalaria Dr. Enrique Tejera. Resultados: Se evaluaron 64 pacientes, de los cuales el 15,62 % presentó coinfección VIH-sífilis, el 80 % fueron hombres, y la edad media de la muestra fue 33,6 ± 14,03 años, el mecanismo de transmisión más frecuente fue HSH en un 50 %, dos terceras partes de los pacientes manifestaron haber tenido 3 o más parejas sexuales en el último año, y uno de ellos trabajaba en la prostitución. En los contactos sexuales 90 % refirió uso ocasional o nulo de las medidas de protección. Los motivos para la realización del diagnóstico de coinfección VIH-sífilis fueron la presencia de signos o síntomas sugestivos de la enfermedad luética (40 %) y el hallazgo casual en el screening del paciente VIH (30 %). El 60 % presentaba sífilis latente y 30 % sífilis secundaria. El 50 % de los pacientes evaluados presentó un valor de LTCD4<200 cel/mm3. Conclusión: Es necesario realizar regularmente investigación de ETS en el paciente con VIH, así como fomentar y desarrollar estrategias preventivas en nuestro medio.


HIV/AIDS remains one of the biggest public health problems worldwide, it shares transmission mechanism with syphilis, so coinfection can occur. Objective: Describe the clinical-epidemiological, serological and immunological characteristics of patients with a recent diagnosis of HIV/AIDS co-infected with syphilis. Methodology: Clinical, descriptive, cross-sectional, retrospective research, supported by a literature review. Patients older than 18 years of age attended in the Infectious Unit of the Dr. Enrique Tejera Hospital City were included. Results: 64 patients were evaluated, of which 15.62 % had HIV-syphilis coinfection, 80 % were men, and the mean age of the sample was 33.6 ± 14.03 years, the most frequent transmission mechanism was 50 % MSM, two thirds of the patients reported having had 3 or more sexual partners in the last year, and one of them worked in prostitution. In sexual contacts 90 % reported occasional or no use of protective measures. The reasons for the diagnosis of HIV-syphilis co-infection were the presence of signs or symptoms suggestive of the disease (40 %) and the casual finding in the screening of the HIV patient (30 %). 60 % had latent syphilis and 30 % secondary syphilis. 50 % of the patients evaluated had a LTCD4 value <200 cel/mm3. Conclusion: It is necessary to regularly conduct STD research in patients with HIV, as well as to promote and develop preventive strategies in our environment.

4.
Arq. ciências saúde UNIPAR ; 23(3): 171-180, set-dez. 2019.
Artigo em Português | LILACS-Express | ID: biblio-1046155

RESUMO

O processo de envelhecimento populacional e o aumento do número de casos de Infecções Sexualmente Transmissíveis (IST) em idosos evidenciam a necessidade de ações voltadas para a terceira idade. Trata-se um estudo analítico observacional transversal, exploratório, com o objetivo de investigar situações de vulnerabilidade relacionadas à IST em idosos usuários de um Centro de Testagem e Aconselhamento para DTS/Aids de um município de médio porte do estado da Bahia, Brasil, no período de 2006 a 2012. Foram utilizados dados secundários de 233 usuários, com 60 anos ou mais, coletados dos Formulários de Entrada do Sistema de Informação do Centro de Testagem e Aconselhamento, prontuários clínicos e folha de descrição do atendimento. Houve predomínio de usuários do sexo masculino (60,94%), faixa etária de 60 a 70 anos (75,97%), cor parda (26,61%), casados (61,80%), aposentados (57,08%) e com escolaridade de 4 a 7 anos de estudo (35,19%). A maioria relatou a relação sexual como tipo de exposição (76,39%), preferência heterossexual (92,27%) e parceria fixa (72,96%). A frequência de uso do preservativo foi baixa com o parceiro não fixo (32,73%) e com o parceiro fixo (5,58%). A prevalência de IST foi 25,32%, com maior percentual entre os homens. A IST mais prevalente foi a hepatite C (10,73%), seguida da hepatite B (8,58%), sífilis (7,73%) e HIV (3,43). A faixa etária menor que 70 anos mostrou associação estatisticamente significativa com a presença de IST. Os resultados evidenciaram práticas sexuais inseguras e elevada vulnerabilidade dos idosos às IST, havendo necessidade de ações preventivas direcionadas a esse grupo populacional, considerando suas necessidades e especificidades.


The population aging process and the increase in the number of cases of Sexually Transmitted Infections (STI) in the elderly shows the need of actions aimed at that population. This is an exploratory, observational, cross-sectional study to investigate vulnerability situations related to Sexually Transmitted Infections in elderly users of an STD/AIDS Counseling Center of a medium-sized city in the state of Bahia, Brazil, from 2006 to 2012. The study used secondary data from 233 users aged 60 or older, collected from the Counseling Center Information System Admission Forms, clinical records and service description sheet. There was a predominance of male users (60.94%), 60 to 70 years old (75.97%), brown (26.61%), married (61.80%), retired (57,8%) and with 4 to 7 years of schooling (35,19%). Most reported sexual intercourse as the exposure type (76.39%), heterosexual preference (92.27%) and stable partnership (72.96%). The frequency of condom use was low with non-stable partners (32.73%) and with stable partners (5.58%). The prevalence of STI was 25.32%, with greater percentage among men. The most prevalent STI was hepatitis C (10.73%), followed by hepatitis B (8.58%), syphilis (7.73%) and HIV (3.43). The age group younger than 70 years showed a statistically significant association with the presence of STI. The results evidenced unsafe sexual practices and high vulnerability of the elderly to STIs, requiring preventive actions aimed at that population group, considering their needs and specificities.

5.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 50(5): 725-730, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31762245

RESUMO

OBJECTIVE: To understand the relationship between obesity and depression in the elderly in China, and to explore whether there are differences between the genders. METHODS: The data were collected from the 2015 China Health and Retirement National Investigation (China Health and Retirement Longitudinal Study, CHARLS). The respondents were grouped according to depressive status. The difference of depressive status between the elderly male and female groups was examined by Chi-square test. The relationship between depression, obesity and the other sociological factors was analyzed by binary logistic regression. RESULTS: There were 4 019 valid cases, including 2 109 males (52.48%) and 1 910 females (47.52%). All the respondents were aged 60 years and over. There were 474 cases of central obesity (11.79%) and 2 418 cases of abdominal obesity (60.16%). There were significant differences in central obesity and abdominal obesity between the elderly male and female groups (P < 0.001). 1 304 cases suffered from depression, accounting for 32.45%, of which 539 cases were male (41.33%) and 765 cases were female (58.67%). Different groups of gender, central obesity and abdominal obesity had significant differences in depressive status (P < 0.001). The results of univariate analysis indicated that the characteristics of female, divorced/widowed/unmarried, in rural areas, having chronic diseases and functional loss were the risk factors for depression. The results of multivariate logistic regression analysis indicated that, in terms of the total sample, after adjustment for the confounding factors, both central obesity and abdominal obesity groups were less likely to suffer from depression. After stratified by gender, both central obesity and abdominal obesity were negatively correlated with depression. CONCLUSIONS: The elderly with central obesity or abdominal obesity are less likely to suffer from depression, regardless of gender.


Assuntos
Depressão/complicações , Obesidade Abdominal/complicações , Idoso , China/epidemiologia , Feminino , Humanos , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade
6.
Int J Oral Implantol (New Malden) ; 12(4): 501-510, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31781702

RESUMO

PURPOSE: This prospective study aims to evaluate the clinical outcomes of 'All-on-four' rehabilitations in controlled human immunodeficiency virus (HIV)-positive patients. MATERIALS AND METHODS: Edentulous patients requiring an implant prosthetic restoration of one or both jaws were enrolled in the present study. Each patient received at least one fixed full-arch prosthesis. Four implants, immediately loaded, were placed in each jaw using the 'All-on-four' protocol. Marginal bone loss, implant and prosthetic failure, biological and mechanical complications, and serological levels (CD4 cell count, CD4/CD8 ratio, and HIV viral load) were recorded up to 7-year follow-up. RESULTS: A total of 116 implants were placed in 24 patients, and 29 rehabilitations based on the 'All-on-four' concept were achieved. Implant failures were registered in four patients (10 of 116 implants), and the implant survival rate was 91.37%. At the 7-year radiographic evaluation, peri-implant crestal bone loss averaged 1.91 ± 1.3 mm for upright maxillary implants (n = 30 implants) and 1.79 ± 1.28 mm for tilted maxillary implants (n = 30 implants). In the mandible, mean peri-implant crestal bone loss was 1.54 ± 1.27 mm for upright implants (n = 28) and 1.5 ± 1.3 mm for tilted implants (n = 28). No statistically significant correlation was found between serological parameters and marginal bone levels at 6 months, or through 7 years of annual follow-up (P > 0.05). A statistically significant linear correlation (P < 0.001) was found between early implant failure and HIV viral load. The CD4/CD8 ratio was significantly correlated with late implant failure (P = 0.009). CONCLUSIONS: Within the limitations of this prospective 7-year longitudinal study, HIV-positive patients with a stable immune system can be candidates for the 'All-on-four' treatment concept.


Assuntos
Perda do Osso Alveolar , Implantes Dentários , Infecções por HIV , Implantação Dentária Endo-Óssea , Prótese Dentária Fixada por Implante , Falha de Restauração Dentária , Seguimentos , Humanos , Estudos Longitudinais , Estudos Prospectivos
7.
Medicine (Baltimore) ; 98(44): e17744, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689826

RESUMO

Congenital syphilis (CS) can cause serious impact on the fetus. However, congenital syphilis presenting as sepsis is a critical condition but hardly identified by the clinic for the first time. In this study, we aimed to identify the benefit of earlier and accurate diagnosis for the infants who suffer congenital syphilis presenting as sepsis.A retrospective study was performed with patients diagnosed of congenital syphilis presenting as sepsis who were the inpatients in the West China Second Hospital between 2011 and 2018. The control group was collected in the neonatal sepsis patients whose blood culture are positive.Fifty-eight patients were included in the study. In the congenital syphilis group, one patient died and 12 (41.3%) patients get worse to MODS (multiple organ dysfunction syndrome). Symptoms, signs, and lab examinations are found to be significantly different (P < .05) between two groups as below, including rash, palmoplantar desquamation, abdominal distension, splenomegaly, hepatomegaly, etc. And, at the aspect of Hb, PLT, WBC, CRP, ALT, AST, these differences occurred in the different groups. It is obvious that the prognosis of children with syphilis is worse. According to a comparison between the different outcomes in the CS, the worse outcome subgroup of patients is significantly younger and have more severely impaired liver function.Because of the high mortality of these infants, pediatricians should improve awareness of CS. Syphilis screening is recommended for pregnant women.


Assuntos
Sepse Neonatal/diagnóstico , Complicações Infecciosas na Gravidez/diagnóstico , Sepse/diagnóstico , Sífilis Congênita/diagnóstico , Sífilis/diagnóstico , Estudos de Casos e Controles , China , Diagnóstico Diferencial , Diagnóstico Precoce , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Insuficiência de Múltiplos Órgãos/diagnóstico , Insuficiência de Múltiplos Órgãos/microbiologia , Insuficiência de Múltiplos Órgãos/mortalidade , Sepse Neonatal/microbiologia , Sepse Neonatal/mortalidade , Gravidez , Complicações Infecciosas na Gravidez/microbiologia , Complicações Infecciosas na Gravidez/mortalidade , Estudos Retrospectivos , Sepse/microbiologia , Sepse/mortalidade , Sífilis/microbiologia , Sífilis/mortalidade , Sorodiagnóstico da Sífilis , Sífilis Congênita/mortalidade
8.
Pan Afr Med J ; 33: 328, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31692786

RESUMO

Urethral stricture is a disease whose cause and management vary according to the context. This study aims to analyze the epidemiological etiological and therapeutic features of urethral stricture in our department. We conducted a longitudinal cross-sectional study of patients with acquired urethral stricture admitted to our department between March 2014 and February 2016. The average age of our patients was 24.5 years (10 and 81years). The diagnosis was confirmed by retrograde and voiding Urethro-Cystography (UCG). The average stricture length was 2.28cm (0.5-5cm). The therapeutic approaches included: resection with termino-terminal anastomosis; retrograde dilatation etc. Outcome assessment performed 6-15 months after surgery was satisfactory with absence of recidivism, PMR ≤30cc and strong urine flow and weak in the case of recurrence of dysuria or PMR ≥100cc. Urethral stricture accounted for 7.14% of our urologic treatments. Most of our patients were farmers from the rural area. A history of recurrent urethritis was most often reported by our patients and 78,57% of them were married men, among whom 91% were polygamous). The main reason for consultation was dysuria (50% of the study population) and 50.01% of our patients had secondary urinary tract infection, most commonly caused by Escherichia coli. The main cause of urethral stricture was an infection (56.52%). The most affected area was the bulbar urethra (45.60% of cases). UCG was the most used technique (39.13%). Overall outcomes were good (85,65%) and failure rate reached 13.04%; the highest success rate was achieved with resection with anastomosis (94.44% respectively). Urethral stricture is common among young people. Infection is the main cause in our department. Prevention is essential as well as an efficient and effective management of sexually transmitted infections.


Assuntos
Anastomose Cirúrgica/métodos , Disuria/etiologia , Estreitamento Uretral/cirurgia , Uretrite/etiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Estudos Transversais , Cistografia/métodos , Disuria/epidemiologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Estreitamento Uretral/diagnóstico , Uretrite/epidemiologia , Infecções Urinárias/epidemiologia , Infecções Urinárias/etiologia , Adulto Jovem
9.
Zhonghua Shao Shang Za Zhi ; 35(11): 804-810, 2019 Nov 20.
Artigo em Chinês | MEDLINE | ID: mdl-31775469

RESUMO

Objective: To explore the development trajectories of quality of life and acceptance of disability of burn patients in the rehabilitation treatment stage and the influencing factors. Methods: Totally 207 burn patients, including 157 males and 50 females, aged (40±13) years, who were in the rehabilitation treatment stage were selected by convenient sampling method from October 2016 to July 2017 in the Department of Burns of Fujian Medical University Union Hospital for this longitudinal study. At discharge and 1, 3, and 6 months after discharge, the patient's quality of life and acceptance of disability were scored using the Burn Specific Health Scale-Brief and Chinese Version of Acceptance of Disability Scale-Revised respectively. Taking the intercept, the slope, and the curve slope as latent variables, the latent second growth curve model was constructed for the quality of life and the acceptance of disability. The robust maximum likelihood estimation (MLR) method was used to estimate the mean, the variance, and the covariance, so as to analyze the discharge level, the growth rate, the acceleration, and the correlation among them. Taking the acceptance of disability, the gender, the cause of burn, the severity of burn, the existence of complications, the payment way, and the education level as covariates, the latent second growth curve model was constructed for the quality of life. The MLR method was used to estimate the influence of covariates on the discharge level, the growth rate, and the acceleration of the quality of life. Results: At discharge and 1, 3, and 6 months after discharge, the quality of life scores of patients were (102±36), (111±36), (118±37), and (122±37) points respectively, and the acceptance of disability scores were (73±17), (75±17), (77±17), and (78±18) points respectively. The estimated mean intercept of the quality of life and the acceptance of disability were 101.680 and 72.993 respectively at discharge, both of which showed a curve increasing trend in 1, 3, and 6 months after discharge (estimated mean slope=11.024, 3.086, t=15.376, 7.476, P<0.01), and the increasing rate (acceleration) gradually slowed down (estimated mean curve slope=-1.393, -0.426, t=-13.339, -4.776, P<0.01). There were significant individual differences in the discharge level and the acceleration of quality of life of patients (estimated intercept variance=1 174.527, t=9.332; estimated curve slope variance=2.379, t=6.402; P<0.01). There were significant individual differences in the discharge level, the growth rate, and the acceleration of patients' acceptance of disability (estimated intercept variance=267.017, t=9.262; estimated slope variance=32.264, t=2.356; estimated curve slope variance=0.882, t=2.939; P<0.05 or P<0.01). There was no significant correlation among the discharge level, the growth rate, and the acceleration of the quality of life and those of the acceptance of disability of patients (estimated intercept and slope=37.273, -1.457, t=0.859, -0.131; estimated intercept and curve slope=-6.712, -0.573, t=-1.089, -0.248; estimated slope and curve slope=-5.494, -5.988, t=-0.930, -2.512; P>0.05). Among the time-constant covariates, only the severity of burn and the presence of complications had a significant impact on the quality of life of patients at discharge (estimated intercept=-10.721, 5.522, t=-6.229, 1.977, P<0.05 or P<0.01). At discharge and 1, 3, and 6 months after discharge, the level of acceptance of disability had a positive impact on the quality of life of patients (standardized regression coefficient=0.616, 0.669, 0.681, 0.678, t=18.874, 21.660, 22.824, 22.123, P<0.01). Conclusions: The initial levels of quality of life and acceptance of disability of burn patients in the rehabilitation treatment stage are relatively low, both with a curve increasing trend over time, and the increasing rate gradually slows down. Patients with complications and serious burns have poor quality of life at discharge, while the acceptance of disability has a positive impact on the quality of life.


Assuntos
Queimaduras/psicologia , Queimaduras/reabilitação , Qualidade de Vida , Adaptação Psicológica , Adulto , Queimaduras/fisiopatologia , Pessoas com Deficiência/psicologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade
10.
Pan Afr Med J ; 33: 222, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31692792

RESUMO

Introduction: HIV-2, endemic in West Africa, has a natural resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) which makes it difficult to treat it in developing countries. Methods: We conducted a descriptive, longitudinal, prospective study over the period November 2005-June 2017. Virologic failure has been defined as any viral load greater than 50 copies/ml after 6 months of ARV treatment administered twice. Assays for detecting drug-resistance mutations was performed in the protease-coding region and in the reverse transcriptase-coding region. Results: Data from a total of 110 patients were collected. The patients had a median age of 46 years (ranging from 18 to 67) with a sex-ratio F/M of 2.54. At inclusion, viral load could be assessed in 44% of cases with a median of 935cp/ml (ranging from 17 to 144038). Antiretroviral regimen consisted of a combination of 2 NRTIs and 1IP in 94% of cases. The median follow-up was 1200 days (ranging from 1 to 3840); 94 then 76 patients completed their 12-month and 24-month assessments respectively. At 24-month follow-up, 39 patients had virologic failure, reflecting a prevalence of 39% estimated at 33% at 12-month follow-up and at 11% at 24-month follow-up; NRTIs resistance was observed in 45% of patients, IP resistance in 41% of patients while multi-NRTIs resistance and multi-IP resistance in 30% of patients. Conclusion: Currently, there is an urgent need to make available the new therapeutic classes of ARV for second line ART for patients living with HIV-2 with therapeutic failure in resource-limited settings.


Assuntos
Infecções por HIV/tratamento farmacológico , Inibidores da Protease de HIV/administração & dosagem , HIV-2/isolamento & purificação , Inibidores da Transcriptase Reversa/administração & dosagem , Adolescente , Adulto , Idoso , Farmacorresistência Viral/genética , Quimioterapia Combinada , Feminino , Seguimentos , Infecções por HIV/epidemiologia , Infecções por HIV/virologia , Inibidores da Protease de HIV/farmacologia , HIV-2/efeitos dos fármacos , HIV-2/genética , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Inibidores da Transcriptase Reversa/farmacologia , Senegal/epidemiologia , Carga Viral , Adulto Jovem
11.
Pan Afr Med J ; 33: 203, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31692798

RESUMO

Introduction: Medication-overuse headaches (MOHs) are the least studied of all headaches in Africa. Methods: We conducted a longitudinal study in order to describe our experience with patients placed in Neurology Outpatient observation in Brazzaville over a period of 4 years, from September 2010 to August 2014. All patients with chronic primary headaches, according to the International Classification of Headache Disorders (ICHD) (2nd edition), were included in the study. All patient with secondary headaches or who hadn't given consent were excluded. The patients were divided into two groups: those who had progressed to medication-overuse and those who didn't meet the criteria for medication-overuse (without-MOH). The variables used were the sociodemographic characteristics of patients, the clinical features of primary headaches and MOH treatment. Results: The study population was constituted by 193 patients out of 212. The average age of patients was 42 ± 14 years, of whom 66.32% were women. MOH rate was 35.75%. The associated factors were: early age (p=0.003), concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and paracetamol (p=0.0001) as well as self-medication (p<0.0001). By contrast, higher education (p<0.0001) and the use of NSAID alone (0.002) were protective factors against the onset of MOH. Ambulatory withdrawal was the most practiced treatment and amitriptyline was the most commonly used medication. Conclusion: Medication-overuse headaches are frequent in patients placed in Neurology Outpatient observation in Africa and deserve identification for a better management.


Assuntos
Transtornos da Cefaleia Secundários/epidemiologia , Transtornos da Cefaleia/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Congo , Escolaridade , Feminino , Transtornos da Cefaleia/terapia , Transtornos da Cefaleia Secundários/terapia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Fatores de Proteção , Fatores de Risco , Adulto Jovem
13.
Rev Esp Salud Publica ; 932019 Dec 02.
Artigo em Espanhol | MEDLINE | ID: mdl-31782409

RESUMO

OBJECTIVE: Syphilis cases have increased in recent years; early detection and treatment are fundamental for the control of the disease. Our objective is to analyze the epidemiological characteristics of patients diagnosed of syphilis in the Health Sector of Calatayud from 2013 to 2017. METHODS: Retrospective observational descriptive study of patients diagnosed with syphilis in the Ernest Lluch Hospital (January 2013 - May 2017). Epidemiological and clinical variables were analyzed. The patient search was carried out through the Omega® software program of the Microbiology Service and for the statistical analysis, the Chi-square test was applied for one single proportion and to compare proportions, and the Fisher test through the Graphpad analysis program of 2x2 contingency tables. The level of statistical significance required in all cases was p<0.05. RESULTS: 72 patients with syphilis were diagnosed, 61% men (average age of 43) and 39% women (average age of 35). 51% were of foreign nationality (49% of men). 80% of the Spanish patients were men. Only one patient was HIV+ (1.38%), 11% suffered from hepatitis B and 3% suffered from hepatitis C. Latent and late forms of syphilis predominated (71%). 50% of women were pregnant (79% were foreigners, p<0.05). 21% of the patients were into a penitentiary center, all of them were men (53% were foreigners). No significant differences were observed in the number of cases, although in 2017 it can be inferred that there could be an increase in cases. CONCLUSIONS: The syphilis is more frequent in young men of foreign nationality. Percentages of men and women of foreign origin with syphilis are very similar, while percentage of Spanish men syphilis patients, is much higher than women. Among pregnant women, the percentage of foreigners is higher (p<0.05). We do not detect higher risk of suffering syphilis in imprisoned individuals. Taking into account the profile of patients in our study area, and the benefit of the treatment, we consider valuing early detection of the disease, mainly in young men and pregnant women of foreign origin.

14.
Rev Esp Salud Publica ; 932019 Dec 02.
Artigo em Espanhol | MEDLINE | ID: mdl-31782410

RESUMO

OBJECTIVE: The partner notification is one of the main activities of epidemiological surveillance in Public Health. The primary objective was to estimate the compliance of the partner notification by health professionals who reported sexually transmitted diseases (HIV, Gonorrhoea, Syphilis and Chlamydia) during 2017 in Lleida's regions. METHODS: We carried out a descriptive epidemiological study of prevalence about the compliance of partner notification. Data collection was done by epidemiological surveys of these notifiable diseases and additional information was recovered through medical record and interview with professionals. The factors associated with the lack of partner notification were studied through the odds ratio (OR) and its 95% confidence interval (CI). ORs were adjusted (ORa) with multivariate logistic regression models. RESULTS: We studied 203 STD cases with an average age of 30.6 years (SD=11.1); 32.5% were women. There was 46.3% without partner notification. The main cause of this absence was the lack of patient cooperation (23.4%). The variables associated with the lack of partner notification were the male sex (aOR-3.5; CI95%=1.6-7.5), gonococcal infection (aOR-4.9; CI95%=1.2-19.8), chlamydia infection (aOR-3.9; CI95%=0.9-16.1) and homosexual/bisexual sexual orientation (aOR-2.2; CI95%=0.9-5.4). CONCLUSIONS: Compliance of partner notification is low and it is related to male sex, sexual orientation (homosexual/bisexual/transsexual) and type of infection (Gonorrhoea and Chlamydia). Reducing the social stigma associated with sexual orientation and improving the information of health professionals could favour the contact studies.

15.
Gac Med Mex ; 155(5): 464-472, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31695231

RESUMO

Introduction: Congenital syphilis continues to be a public health problem in Mexico. Objective: To assess the similarities and differences between national standards, guidelines and international documents related to the detection of syphilis in pregnant women and congenital syphilis. Method: Two algorithms were developed based on the standard of female care during pregnancy and on the standard for prevention and control of sexually transmitted infections. Based on the Centers for Disease Control (CDC) guidelines, algorithms were developed for syphilis during pregnancy, syphilis in the newborn and sexual contacts. Results: The standard for pregnancy mentions that syphilis testing should be carried out in every pregnant woman on her first contact or at delivery, without diagnostic tests being specified. The Official Mexican Standard (NOM) on sexually transmitted infections mentions the traditional algorithm for syphilis detection, treatment follow-up, coinfection with human immunodeficiency virus and congenital syphilis criteria. The CDC recommend reverse algorithm, antibody titer, treatment and follow-up as part of diagnosis. Conclusions: The elimination of mother-to-child transmission of syphilis requires NOMs updating and homogenizing, as well as the study of stillbirths and neonates born to mothers with syphilis.

16.
BMJ ; 367: l5837, 2019 10 30.
Artigo em Inglês | MEDLINE | ID: mdl-31666218

RESUMO

OBJECTIVE: To evaluate whether calorie labeling of menus in large restaurant chains was associated with a change in mean calories purchased per transaction. DESIGN: Quasi-experimental longitudinal study. SETTING: Large franchise of a national fast food company with three different restaurant chains located in the southern United States (Louisiana, Texas, and Mississippi) from April 2015 until April 2018. PARTICIPANTS: 104 restaurants with calorie information added to in-store and drive-thru menus in April 2017 and with weekly aggregated sales data during the pre-labeling (April 2015 to April 2017) and post-labeling (April 2017 to April 2018) implementation period. MAIN OUTCOME MEASURES: Primary outcome was the overall level and trend changes in mean purchased calories per transaction after implementation of calorie labeling compared with the counterfactual (ie, assumption that the pre-intervention trend would have persisted had the intervention not occurred) using interrupted time series analyses with linear mixed models. Secondary outcomes were by item category (entrees, sides, and sugar sweetened beverages). Subgroup analyses estimated the effect of calorie labeling in stratums defined by the sociodemographic characteristics of restaurant census tracts (defined region for taking census). RESULTS: The analytic sample comprised 14 352 restaurant weeks. Over three years and among 104 restaurants, 49 062 440 transactions took place and 242 726 953 items were purchased. After labeling implementation, a level decrease was observed of 60 calories/transaction (95% confidence interval 48 to 72; about 4%), followed by an increasing trend of 0.71 calories/transaction/week (95% confidence interval 0.51 to 0.92) independent of the baseline trend over the year after implementation. These results were generally robust to different analytic assumptions in sensitivity analyses. The level decrease and post-implementation trend change were stronger for sides than for entrees or sugar sweetened beverages. The level decrease was similar between census tracts with higher and lower median income, but the post-implementation trend in calories per transaction was higher in low income (change in calories/transaction/week 0.94, 95% confidence interval 0.67 to 1.21) than in high income census tracts (0.50, 0.19 to 0.81). CONCLUSIONS: A small decrease in mean calories purchased per transaction was observed after implementation of calorie labeling in a large franchise of fast food restaurants. This reduction diminished over one year of follow-up.


Assuntos
Ingestão de Energia/fisiologia , Fast Foods/efeitos adversos , Rotulagem de Alimentos , Obesidade/prevenção & controle , Restaurantes/estatística & dados numéricos , Comportamento do Consumidor/estatística & dados numéricos , Fast Foods/estatística & dados numéricos , Dieta Saudável , Humanos , Renda/estatística & dados numéricos , Estudos Longitudinais , Ensaios Clínicos Controlados não Aleatórios como Assunto , Obesidade/epidemiologia , Obesidade/etiologia , Prevalência , Sudeste dos Estados Unidos/epidemiologia
19.
Medicina (B Aires) ; 79(5): 415-418, 2019.
Artigo em Espanhol | MEDLINE | ID: mdl-31671396

RESUMO

We present the case of a 62-year-old woman who consulted for fever (38°), stabbing thoracic pain (on one side), and pruritic skin lesions. She underwent peripheral blood tests, chest X-rays and CT. Her symptoms were interpreted as severe communityacquired pneumonia. After a treatment with antibiotics, her skin lesions persisted, and other symptoms were only partially relieved. A skin biopsy was performed, which revealed Treponema pallidum. Such finding was confirmed through positive serum VDRL and FTA-ABS tests. The patient received 4 doses of benzathine penicillin G with favorable evolution of skin lesions and improvement of radiological images.

20.
Pan Afr Med J ; 33: 252, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692814

RESUMO

Introduction: HIV and syphilis are major public health problems in Morocco. The region of Souss-Massa, south-west of the country, hold more than 24% of HIV seropositive cases registered in Morocco during 2009. The aim of this study is to evaluate the seroprevalence of syphilis among HIV seropositive patients in the region of Souss-Massa, south-west of Morocco. Methods: To evaluate the seroprevalence of syphilis and neurosyphilis among HIV seropositive patients, we retrospectively investigated the medical records of HIV-infected patients attending the regional hospital located in the city of Agadir, during the period comprised between 2011 and 2016. Results: The population studied involved 1381 males (49.18%) and 1427 females (50.82%) HIV seropositive patients. Among them, 481 patients were seropositive for syphilis and three cases were diagnosed with neurosyphilis. The sex ratio distribution was 243 male (52.71%) and 218 female (47.29%). The prevalence of syphilis among the studied population was estimated to 16.42% with a slight dominance in male (17.63%) compared to female (15.28%). By contrast, neurosyphilis was only detected in male patients, with a prevalence estimated to 0.11%. Conclusion: Even if the prevalence of HIV and syphilis is stable in the region of Souss-Massa, the prevalence of syphilis among HIV seropositive patients remained high and correlated positively with that of HIV infection. We did not find a significant difference between the genders, in relation to the prevalence of HIV and syphilis. We concluded that it was essential to continue monitoring the population, in order to improve the prevention and the access to the medical care in the south-west of Morocco.


Assuntos
Infecções por HIV/epidemiologia , Neurossífilis/epidemiologia , Sífilis/epidemiologia , Feminino , Humanos , Masculino , Marrocos/epidemiologia , Prevalência , Estudos Retrospectivos , Estudos Soroepidemiológicos , Distribuição por Sexo
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