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1.
Kasmera ; 48(1): e48118032020, ene-jun 2020.
Artigo em Inglês, Espanhol | LILACS-Express | ID: biblio-1087727

RESUMO

El coronavirus ha generado una suerte de "histeria colectiva" en diversas poblaciones. Por lo tanto, nuestro objetivo fue validar un test que mida el fatalismo ante la posibilidad de contagio por el coronavirus. Se realizó un proceso de validación en cinco fases: Búsqueda de la literatura y construcción del primer borrador, juicio de fondo con 28 expertos, evaluación de forma con 280 personas, piloto para análisis factorial exploratorio en 389 personas (en ambas se contó con 17 ciudades de Perú) y confirmación de la validez del constructo final con 10 expertos. Los estadísticos de KMO (0,779) y Bartlett (572,6; gl = 21; p < 0,001) presentaron resultados aceptables y significativos. La varianza total explicada por los 7 ítems distribuidos en 2 factores es de 58,9%, lo cual es adecuado. Los análisis robustos muestran que la estructura factorial es satisfactoria (X2 = 21,161; p = 0,007; CFI = 0,984; GFI = 0,996; TLI = 0,957; RMSEA = 0,067 y RMSR = 0,033). Se generó una escala de 7 ítems para medir las medidas fatalistas que las personas podrían tener o tomar si es que llegasen a enfermarse del coronavirus


Coronavirus has generated a kind of "mass hysteria" in various populations. A validation process was generated for a test that measures fatalism in the face of the possibility of infection by the coronavirus. A validation process was carried out in five phases: literature search and construction of the first draft, substantive judgement with 28 experts, formal evaluation with 280 people, pilot for exploratory factor analysis in 389 people (in both cases there were 17 cities in Peru) and confirmation of the validity of the final construct with 10 experts. The statisticians of KMO (0.779) and Bartlett (572.6; gl = 21; p < 0.001) presented acceptable and significant results. The total variance explained by the 7 items distributed in 2 factors is 58.9%, which is adequate. Robust analyses show that the factor structure is satisfactory (X2 = 21.161; p = 0.007; IFC = 0.984; GFI = 0.996; TLI = 0.957; RMSEA = 0.067 and RMSR = 0.033). A 7-item scale was generated to measure the fatalistic measures people might have or take if they became ill with the coronavirus

3.
Ars pharm ; 61(2): 63-79, abr.-jun. 2020. tab, ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-188101

RESUMO

INTRODUCCIÓN: En diciembre de 2019, se detectaron los primeros casos de enfermedad respiratoria causada por un coronavirus emergente, al que se denominó SARS-CoV-2, que en los primeros meses de 2020 se ha extendido por todo el mundo con características de pandemia. MÉTODO: Se examinaron las publicaciones más relevantes en relación con los objetivos de la revisión. RESULTADOS: La enfermedad, conocida como COVID-19, cursa con tos, fiebre y dificultad respiratoria. Las formas más graves, que afectan principalmente a personas de edad avanzada y con determinadas comorbilidades, se manifiestan por afectación de la función respiratoria, que requiere ventilación mecánica, y síndrome de respuesta inflamatoria sistémica, que puede conducir a un choque séptico con fallo multiorgánico, y altas tasas de mortalidad. En esta revisión se examina el estado actual de conocimientos sobre las características y origen del SARS-CoV-2, su replicación, y la patogénesis, clínica, diagnóstico, tratamiento y prevención de COVID-19. CONCLUSIONES: Las características del SARS-CoV-2 y la clínica de COVID-19 son bien conocidas. La PCR es la técnica de referencia para el diagnóstico de laboratorio; se dispone de ensayos para detección de antígenos y de anticuerpos, con margen de optimización. Los protocolos de tratamiento incluyen la corrección de la respuesta inflamatoria sistémica y administración de agentes antivirales. Existen vacunas en desarrollo


INTRODUCTION: In December 2019, the first cases of respiratory disease caused by an emerging coronavirus were detected. The causative agento f the outbreak was called SARS-CoV-2, and in the first months of 2020 it spread throughout the world as a pandemic. METHOD: The most relevant publications concerned with the aims of the review were examined. RESULTS: The disease, known as COVID-19. Patients show cough, fever, and respiratory distress. The most severe forms, mainly affecting the elderly and associated with various comorbidities, are manifested by impaired respiratory function, requiring mechanical ventilation, and systemic inflammatory response syndrome, which can lead to septic shock with multi-organ failure and high mortality rates. This review examines the current state of knowledge about the characteristics and origin of SARS-CoV-2, its replication, and the pathogenesis, clinical, diagnosis, treatment, and prevention of COVID-19. CONCLUSIONS: The characteristics of SARS-CoV-2 and the clinical manifestations of COVID-19 are well known. PCR is the reference technique for laboratory diagnosis; assays for the detection of antigens and antibodies are available, with optimization possibilities. Treatment protocols include attenuation of the systemic inflammatory response and administration of antiviral agents. There are vaccines in development


Assuntos
Humanos , Infecções por Coronavirus , Pneumonia Viral , Betacoronavirus/patogenicidade , Pandemias , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/prevenção & controle , Infecções por Coronavirus/terapia , Pneumonia Viral/diagnóstico , Pneumonia Viral/prevenção & controle , Pneumonia Viral/terapia
4.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47448

RESUMO

Estudo conduzido por Chen e publicado na revista Lancet avaliou a potencial transmissão vertical da infecção por COVID-19. Para isso foram avaliadas 9 gestantes diagnosticadas com pneumonia por COVID-19 através de seus dados clínicos, laboratoriais, e TC pulmonar.


Assuntos
Aleitamento Materno , Betacoronavirus , Pneumonia Viral , Infecções por Coronavirus , Transmissão Vertical de Doença Infecciosa
5.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47374

RESUMO

Este mapa apresenta uma visão geral da evidência sobre a aplicação das MTCI com base na caracterização de 125 estudos de revisão e estudos clínicos controlados, distribuídos em uma matriz com 57 intervenções sobre uma série de desfechos clínicos agrupados em 3 categorias: Melhora da imunidade/efeito antiviral para vírus respiratórios; Manejo complementar dos sintomas de infecções respiratórias; e Contribuições à Saúde Mental/Emocional em situações de trauma. As intervenções representam especialmente medicamentos fitoterápicos, medicina e terapias tradicionais chinesas, terapias mente-corpo como meditação e yoga, probióticos e outros suplementos nutricionais além de formulações dinamizadas da homeopatia.


Assuntos
Betacoronavirus , Pneumonia Viral/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Infecções por Coronavirus/prevenção & controle , Pandemias/prevenção & controle , Resultado do Tratamento , Medicina Baseada em Evidências/métodos , Medicina Tradicional Chinesa/métodos
6.
Recurso na Internet em Espanhol | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47375

RESUMO

Este mapa presenta una visión general sobre posibles contribuciones de las MTCI a varias dimensiones de la pandemia por COVID-19. Dichas contribuciones se organizaron en tres categorías: Mejora de la inmunidad y efecto antiviral ante diferentes virus respiratorios; tratamiento complementario de los síntomas de las infecciones respiratorias; y salud mental en situaciones de crisis. Para el mapa se caracterizaron 125 estudios de revisión y estudios clínicos controlados, distribuidos en una matriz con 57 intervenciones para las tres categorías mencionadas. Las intervenciones representan especialmente medicinas herbales/ fitoterapia, medicina tradicional china, terapias de cuerpo-mente como la meditación y el yoga, probióticos y otros suplementos nutricionales además de formulaciones de homeopatía.


Assuntos
Betacoronavirus , Pneumonia Viral/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Infecções por Coronavirus/prevenção & controle , Pandemias/prevenção & controle , Resultado do Tratamento , Medicina Baseada em Evidências/métodos , Medicina Tradicional Chinesa/métodos
7.
Recurso na Internet em Inglês | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47376

RESUMO

This map presents an overview of the evidence on the application of TCIM based on the characterization of 125 review studies and controlled clinical studies distributed in a matrix with 57 interventions on a series of clinical outcomes grouped into 3 major categories: Improved immunity/antiviral effect for respiratory viruses; Complementary management of symptoms of respiratory infections; and Mental health. The interventions represent especially herbal medicines, traditional Chinese medicine and therapies, mind-body therapies like meditation and yoga, probiotics and other nutritional supplements besides homeopathy formulations.


Assuntos
Betacoronavirus , Pneumonia Viral/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Infecções por Coronavirus/prevenção & controle , Pandemias/prevenção & controle , Resultado do Tratamento , Medicina Baseada em Evidências/métodos , Medicina Tradicional Chinesa/métodos
8.
J Clin Microbiol ; 2020 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-32350048

RESUMO

Multiple laboratory developed tests and commercially available assays have emerged to meet diagnostic needs related to the SARS-CoV-2 pandemic. To date, there is limited comparison data for these different testing platforms. We compared the analytical performance of a laboratory developed test (LDT) developed in our clinical laboratory based on CDC primer sets and four commercially available, FDA emergency use authorized assays for SARS-CoV-2 (Cepheid, DiaSorin, Hologic Panther, and Roche Cobas) on a total of 169 nasopharyngeal swabs. The LDT and Cepheid Xpert Xpress SARS-CoV-2 assays were the most sensitive assays for SARS-CoV-2 with 100% agreement across specimens. The Hologic Panther Fusion, DiaSorin Simplexa, and Roche Cobas 6800 only failed to detect positive specimens near the limit of detection of our CDC-based LDT assay. All assays were 100% specific, using our CDC-based LDT as the gold standard. Our results provide initial test performance characteristics for SARS-CoV-2 RT-PCR and highlight the importance of having multiple viral detection testing platforms available in a public health emergency.

9.
Jpn J Infect Dis ; 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-32350226

RESUMO

The COVID-19 outbreak caused by SARS-CoV-2 in Wuhan (China) in December 2019 is currently spreading rapidly and globally. We recently reported a laboratory diagnostic protocol for SARS-CoV-2 based on real-time RT-PCR assays using two primer sets, N and N2. On 30-31 January 2020, the protocol and reagents for these assays were distributed to local public health institutes and quarantine depots in Japan, and nationwide, SARS-CoV-2 diagnostic testing was started. For further validation, the assays were compared with the commercially available kits using SARS CoV-2 viral RNA and the clinical specimens obtained from COVID19-suspected individuals. The LightMix Modular SARS and Wuhan CoV E-gene (LN S&W-E) assay was highly sensitive for SARS-CoV-2, as was the N2 set, and both assays had perfectly consistent results with the clinical specimens. While the LM S&W-E set targets the highly conserved region of the E gene in SARS-CoV and SARS-CoV-2, the N2 set was designed to target the unique region in the SARS-CoV-2 N gene. Thus, the N2 set has high specificity and sensitivity for SARS-CoV-2 detection. These indicate that the protocol using the N and N2 sets is comparable to commercially available kits and is reliable for the laboratory diagnosis of COVID-19.

11.
Turk J Med Sci ; 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-32351103

RESUMO

COVID-19 infection, a highly contagious disease caused by the SARS-CoV virus, and the World Health Organization declared this increasingly spreading disease as a global public health emergency (pandemic). In the diagnosis of COVID-19, the polymerase chain reaction (RT-PCR) is considered as the reference standard test. In the early stages, thorax CT findings could be present even before the onset of symptoms, thorax CT has quite high sensitivity in COVID-19 patients with false negative RT-PCR results, and it has a great importance not only in diagnosis but also in follow up (6,7). We think that it might be beneficial for our radiologist colleagues in the early diagnosis of the imaging features of this disease, by sharing the experiences we have gained by evaluating the typical and relatively atypical CT findings regarding the natural course of the tomographic findings of COVID-19 and when to control CT.

12.
AJR Am J Roentgenol ; : W1-W2, 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-32352310
13.
Oral Dis ; 2020 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-32352615

RESUMO

Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus, SARS-COV-2 was declared a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) in January 2020. Human-to-Human transmission occurs through close contact with an infected person or surfaces that are contaminated with droplets or secretions.

16.
IEEE Rev Biomed Eng ; 2020 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-32356760

RESUMO

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading rapidly around the world, resulting in a massive death toll. Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. Herein, we review the imaging characteristics and computing models that have been applied for the management of COVID-19. CT, positron emission tomography - CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. The quantitative analysis of imaging data using artificial intelligence (AI) is also explored. Our findings indicate that typical imaging characteristics and their changes can play crucial roles in the detection and management of COVID-19. In addition, AI or other quantitative image analysis methods are urgently needed to maximize the value of imaging in the management of COVID-19.

17.
Adv Radiat Oncol ; 2020 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-32377597

RESUMO

Introduction: Patients with cancer are at high-risk for mortality from coronavirus-disease 2019 (COVID-19). Radiation pneumonitis (RP) is a common toxicity of thoracic radiotherapy with overlapping clinical and imaging features with COVID-19, however, RP is treated with high-dose corticosteroids, which may exacerbate COVID-19-associated lung injury. We reviewed patients who presented with symptoms of RP during the intensification of a regional COVID-19 epidemic to report on their clinical course and COVID-19 testing results. Methods: The clinical course and chest computed tomography (CT) imaging findings of consecutive patients who presented with symptoms of RP in March 2020 were reviewed. The first regional COVID-19 case was diagnosed on 3/1/2020. All patients underwent COVID-19 qualitative RNA testing. Results: Four patients with clinical suspicion for RP were assessed. Three out of four patients tested positive for COVID-19. All patients presented with symptoms of cough and dyspnea. Two patients had a fever, of whom only one tested positive for COVID-19. Two patients started on an empiric high-dose corticosteroid taper for presumed RP, but both had clinical deterioration, and ultimately tested positive for COVID-19 and required hospitalization. Chest CT findings in patients suspected of RP, but ultimately diagnosed with COVID-19 showed ground-glass opacities mostly pronounced outside the radiation field. Conclusions: As this pandemic continues, patients with symptoms of RP require diagnostic attention. We recommend that patients suspected of RP be tested for COVID-19 before starting empiric corticosteroids and for careful attention be paid to chest CT imaging in order to prevent potential exacerbation of COVID-19 in these high-risk patients.

18.
Rhinology ; 2020 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-32386285

RESUMO

BACKGROUND: Healthcare workers are at the forefront of the ongoing COVID-19 pandemic and are at high risk for both the contraction and subsequent spread of virus. Understanding the role of anosmia as an early symptom of infection may improve monitoring and management of SARS-CoV2 infection. METHODOLOGY: We conducted a systematic review of the literature of SARS-CoV2 infection/COVID-19 and anosmia to help inform management of anosmia in healthcare works. We report a case series of healthcare workers, who presented with a loss of sense of smell secondary to COVID-19 infection to demonstrate management principles. RT-PCR was used to confirm COVID-19 positivity and psychophysical testing of olfaction was performed using the British version of the University of Pennsylvania Smell Identification Test, UPSIT. RESULTS: The systematic literature search returned 31 articles eligible for inclusion in the study and informed our recommendations for clinical assessment and management. All three healthcare professionals who presented with loss of sense of smell subsequently tested positive for SARS-CoV-2. Psychophysical testing of olfaction using the UPSIT confirmed mild and moderate microsmia in two, respectively, and normosmia at day 17 in one. CONCLUSIONS: Olfactory (± gustatory) dysfunction is indicative of COVID-19 infection and thus has important implications in the context of healthcare workers, or key workers in general, who work in close contact with others if not recognised as suffering from COVID. This leads to a potentially higher likelihood of spreading the virus. In conjunction with our literature review these findings have helped with creating recommendations on the assessment and management of olfactory dysfunction during the ongoing COVID-19 pandemic, both for healthcare workers and patients.

20.
J Clin Virol ; 127: 104383, 2020 Apr 24.
Artigo em Inglês | MEDLINE | ID: mdl-32353760

RESUMO

BACKGROUND: Numerous nucleic acid amplification assays have recently received emergency use authorization (EUA) for the diagnosis of SARS-CoV-2 infection, and there is a need to assess their test performance relative to one another. OBJECTIVES: The aim of this study was to compare the test performance of the Hologic Panther Fusion SARS-CoV-2 assay targeting two regions of open reading frame 1ab (ORF1ab) to a high complexity molecular-based, laboratory-developed EUA from Stanford Health Care (SHC) targeting the SARS-CoV-2 envelope (E) gene. STUDY DESIGN: We performed a diagnostic comparison study by testing nasopharyngeal samples on the two assays. Assay agreement was assessed by overall percent agreement and Cohen's kappa coefficient. RESULTS: A total of 184 nasopharyngeal samples were tested using the two assays, of which 180 showed valid results and were included for the comparative analysis. Overall percent agreement between the assays was 98.3 % (95 % confidence interval (CI) 95.2-99.7) and kappa coefficient was 0.97 (95 % CI 0.93-1.0). One sample was detected on the SHC laboratory developed test (LDT) and not on the Panther Fusion, and had a Ct of 35.9. Conversely, 2 samples were detected on the Panther Fusion and not on the LDT, and had Ct values of 37.2 and 36.6. CONCLUSION: The Panther Fusion SARS-CoV-2 assay and the SHC LDT perform similarly on clinical nasopharyngeal swab specimens. Other considerations, including reagent availability, turnaround time, labor requirements, cost and instrument throughput should guide the decision of which assay to perform.

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