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1.
São Paulo; s.n; 20220720. 50 p.
Tese em Português | LILACS, BBO - Odontologia | ID: biblio-1379730

RESUMO

Nas últimas décadas a sociedade como um todo foi impactada das mais diversas maneiras pelo uso da tecnologia. Inteligência Artificial é o termo usado para se referir a algoritmos que permitem com que computadores realizem tarefas que exigem a percepção humana para serem feitas. O presente estudo tem o objetivo de relatar o que há de mais recente na literatura sobre o tema de Inteligência Artificial na Odontologia, mais propriamente na área de Patologia Oral e Maxilofacial, e realizar um piloto para diferenciação de lesões utilizando software gratuito. Para realizar o estudo, foram selecionados casos específicos dos últimos 20 anos do Serviço de Patologia Oral e Maxilofacial da Universidade de São Paulo, sendo estes casos de lesões benignas e malignas para comparação e poder elucidar como a patologia através da IA pode ser realizada.). Ao finalizar este processo, o modelo de ML identificou as imagens que foram pedidas para que o software analisasse e uma taxa de acurácia foi obtida, que neste caso foi de 98% de assertividade de que a imagem colocada era referente a uma imagem histológica de uma lesão maligna e de 97% para a lesão benigna (neste caso, um carcinoma epidermoide e um fibroma respectivamente). O estudo concluiu que a IA é pouca explorada tanto no âmbito rotineiro quanto acadêmico e que novas pesquisas devem ser realizadas com incentivo a fim de produzir literatura, mostrar aos estudantes o que pode ser realizado com tecnologia apropriada e agilizar o processo diagnóstico, facilitando a vida do profissional e de todo o sistema que o envolve.


Assuntos
Patologia Bucal , Inteligência Artificial , Tecnologia Biomédica
2.
ScientificWorldJournal ; 2022: 3257377, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35833055

RESUMO

Background: Understanding oral aspects of pathology by traditional techniques has always been a paradigm in the field of dental education. Traditional methods of teaching include interaction using black board, projectors, and alternate methods of teaching such as a student-centered approach where live-field demonstrations, audio visual aids, and student interaction are also gaining importance, ultimately promoting active education. The aim of the study was to compare live-field and static-field teaching methods in understanding and retention of the histopathological features in dental students. Methods: This was a cross-sectional analytical study, wherein a uniform cohort of III-year dental students was obtained by randomizing the study subjects. Practical classes were conducted using traditional black board/static pictures and dynamic live-field teaching comprising of microscope connected to an HD screen and projector demonstrating the preferred microscopic field. Alternately, the level of retention of knowledge was measured using customized topic-based tests. The comparison of average scores was done between live-field and static-field teaching groups using the paired t-test. Results: The test scores using the paired t-test were marginally elevated in the conventional mode of teaching; however, it varied with respect to precise topics taken using both the genres of teaching. Conclusion: A balance of both conventional and virtual teaching needs to be achieved to enhance the comprehension in student learning. Nevertheless, in the impending years, advanced research is entailed to see if the virtual mode of teaching could replace the conventional method for the advancement in the study prospects.


Assuntos
Patologia Bucal , Estudantes de Odontologia , Estudos Transversais , Educação em Odontologia/métodos , Humanos , Aprendizagem Baseada em Problemas/métodos , Ensino
3.
Braz Oral Res ; 36: e096, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35830140

RESUMO

We analyzed the distribution characteristics of the scientific production of Brazilian dentistry researchers of the Brazilian National Council for Scientific and Technological Development. The Lattes curriculum data of 211 researchers from Oral Pathology, Oral Surgery, and Oral Medicine fields were included (2018-2020). Over their academic career, 39 researchers published 7,555 papers (average, 175 articles/researcher); 3,876/7,555 papers were indexed in the Web of Science. During 2018-2020, 1,440/7,555 (19%) papers were published. Brazilian dental researchers contribute significantly to international research by participating in scientific journals' editorial boards, evaluating research promotion agencies, training researchers, and contributing to scientific and technological development.


Assuntos
Bibliometria , Cirurgia Bucal , Brasil , Humanos , Patologia Bucal , Pesquisadores
4.
BMC Oral Health ; 22(1): 184, 2022 05 18.
Artigo em Inglês | MEDLINE | ID: mdl-35585582

RESUMO

BACKGROUND: Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. METHODS: 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS) were administered. RESULTS: The Central-South K-OLP (CS-K-OLP) patients reported a higher frequency of pain/burning compared with the K-OLP patients of the North (N-K-OLP) with higher scores in the NRS and T-PRI (p value < 0.001**). The CS-K-OLP and the CS-nK-OLP patients showed higher scores in the HAM-D, HAM-A, PSQI and ESS compared with the Northern patients (p value < 0.001**). Multivariate logistic regression revealed that the NRS and T-PRI showed the greatest increase in the R2 value for the CS-K-OLP (DR2 = 9.6%; p value < 0.001**; DR2 = 9.7% p value < 0.001**; respectively) and that the oral symptoms (globus, itching and intraoral foreign body sensation) and PSQI showed the greatest increase in the R2 value for the CS-nK-OLP (DR2 = 5.6%; p value < 0.001**; DR2 = 4.5% p value < 0.001** respectively). CONCLUSIONS: Pain and mood disorders are predominant in patients with OLP in the Central-South of Italy. Clinicians should consider that the geographical living area may explain the differences in oral symptoms and psychological profile in OLP.


Assuntos
Líquen Plano Bucal , Ansiedade , Estudos Transversais , Humanos , Líquen Plano Bucal/diagnóstico , Dor , Patologia Bucal
6.
Int J Mol Sci ; 23(3)2022 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-35163355

RESUMO

This review article was designed to evaluate the existing evidence related to the molecular processes of SARS-CoV-2 infection in the oral cavity. The World Health Organization stated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission is produced by respiratory droplets and aerosols from the oral cavity of infected patients. The oral cavity structures, keratinized and non-keratinized mucosa, and salivary glands' epithelia express SARS-CoV-2 entry and transmission factors, especially angiotensin converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Replication of the virus in cells leads to local and systemic infection spread, and cellular damage is associated with clinical signs and symptoms of the disease in the oral cavity. Saliva, both the cellular and acellular fractions, holds the virus particles and contributes to COVID-19 transmission. The review also presents information about the factors modifying SARS-CoV-2 infection potential and possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the oral cavity. The PubMed and Scopus databases were used to search for suitable keywords such as: SARS-CoV-2, COVID-19, oral virus infection, saliva, crevicular fluid, salivary gland, tongue, oral mucosa, periodontium, gingiva, dental pulp, ACE2, TMPRSS2, Furin, diagnosis, topical treatment, vaccine and related words in relevant publications up to 28 December 2021. Data extraction and quality evaluation of the articles were performed by two reviewers, and 63 articles were included in the final review.


Assuntos
COVID-19/patologia , Boca , SARS-CoV-2/fisiologia , Enzima de Conversão de Angiotensina 2/metabolismo , Enzima de Conversão de Angiotensina 2/fisiologia , Animais , COVID-19/metabolismo , COVID-19/transmissão , COVID-19/virologia , Humanos , Boca/metabolismo , Boca/patologia , Boca/virologia , Mucosa Bucal/metabolismo , Mucosa Bucal/patologia , Mucosa Bucal/virologia , Patologia Bucal , Receptores Virais/genética , Receptores Virais/metabolismo , SARS-CoV-2/patogenicidade , Serina Endopeptidases/metabolismo , Serina Endopeptidases/fisiologia , Transdução de Sinais/genética , Internalização do Vírus
7.
West Afr J Med ; 39(1): 31-38, 2022 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-35156791

RESUMO

INTRODUCTION: Tissue processing describes the steps involved in infiltrating a well fixed tissue with wax for section cutting on a microtome. Paraffin tissue processing can be performed either manually or by using an automated tissue processor and errors in any of the steps involved would significantly affect histopathology. The aim of this article was to describe to principles of manual tissue processing as performed in the Oral and Maxillofacial Pathology Laboratory of the College of Medicine, University of Lagos, Nigeria (OMFP-CMUL Lab). METHODS: We report the principles of manual tissue processing as performed in the OMFP-CMUL lab using the index case of an 11-year-old girl with a histopathologic diagnosis of unicystic ameloblastoma. RESULTS: Steps of tissue processing included fixation, specimen accessioning, gross examination, decalcification (for tissue specimens containing calcium deposits), dehydration, clearing, infiltration, embedding, sectioning, labeling of tissue blocks, tissue floatation bathing, making the slide and numbering, staining, drying, cover-slipping, and microscopic examination. DISCUSSION: Common errors seen in histopathology laboratories were avoided by the quality control practices of the residents, consultants, laboratory scientists and technicians within the department.


INTRODUCTION: Le traitement des tissus décrit les étapes d'infiltration d'un tissu bien fixé avec de la cire pour la coupe de sections sur un microtome. Le traitement des tissus en paraffine peut être effectué soit manuellement ou à l'aide d'un processeur de tissus automatisé et les erreurs commises dans l'une ou l'autre de ces étapes peuvent affecter de manière significative l'histopathologie. Le but de cet article était de décrire les principes du traitement manuel des tissus tel qu'il est effectué dans le laboratoire de pathologie orale et maxillofaciale du Collège de Médecine de l'Université de Lagos, Nigeria (Laboratoire OMFP-CMUL). MÉTHODES: Nous rapportons les principes du traitement manuel des tissus tels qu'ils sont réalisés dans le laboratoire de l'OMFPCMUL en utilisant le cas d'index d'une fille de 11 ans avec une diagnostic histopathologique d'améloblastome unicystique. RÉSULTATS: Les étapes du traitement des tissus comprennent la fixation, l'accession des spécimens, l'examen macroscopique, la décalcification (pour les spécimens de tissue contenant des dépôts de calcium), la déshydratation, le nettoyage, l'infiltration l'enrobage, la coupe, l'étiquetage des blocs de tissus, la flottaison des tissus, le bain, la fabrication de la lame et la numérotation, la coloration, le séchage, le recouvrement et l'examen microscopique. DISCUSSION: Les erreurs courantes observées dans les laboratoires d'histopathologie ont été évitées grâce aux pratiques de contrôle de qualité des résidents, consultants, des scientifiques et des techniciens de laboratoire au sein du service. CONCLUSION: Cet article élucide les principes du traitement manuel des tissus tel qu'il est effectué dans le laboratoire de l'OMFPCMUL en détaillant leurs protocoles observés et les mesures de prévention des erreurs afin que ces principes et mesures puissent être adoptés dans d'autres laboratoires d'histopathologie ayant des conditions de travail similaires. MOTS CLÉS: Manuel, traitement des tissus, laboratoire de pathologie, Lagos, Nigeria.


Assuntos
Laboratórios , Patologia Bucal , Criança , Feminino , Humanos , Microscopia , Nigéria , Manejo de Espécimes
8.
Microb Pathog ; 164: 105451, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35183701

RESUMO

Rhinoscleroma (RS) is a rare chronic specific progressive granulomatous disease of the upper airway and affect the nasal cavity, larynx, nasopharynx and may spread to the lower respiratory tract. Extra-respiratory involvement has rarely been described. A case report of extra-respiratory RS with oral manifestation in Egyptian female patient has been presented as a tumour extruded from mucosal lining of upper lip. She was living in crowded conditions with malnutrition and poor hygiene. On the first look, the lesion appeared to be carcinoma without any indication of infectious disease, and then patient was prepared for incisional biopsy. Upon clinicopathological evaluation, the diagnosis was made as RS in the granulomatous stage based on the presence of dense plasma cell infiltration with Mikulicz cells and Russell bodies. Long term oral ciprofloxacin 500 mg twice/day was started as a single treatment. By the end of six weeks antibiotic therapy, the large granulomatous mass reached the cicatricial stage, became very stiff fibrotic mass with sclerotic scar, markedly indurated & significantly decreased in size. This case shows the significant of through clinical examination and lab investigations to achieve correct diagnosis.


Assuntos
Rinoscleroma , Ciprofloxacina/uso terapêutico , Feminino , Humanos , Cavidade Nasal/patologia , Nariz , Patologia Bucal , Rinoscleroma/diagnóstico , Rinoscleroma/patologia , Rinoscleroma/terapia
9.
BMC Oral Health ; 22(1): 2, 2022 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-34996437

RESUMO

OBJECTIVES: The goal of the current study was to evaluate the relative frequency of oral and maxillofacial pathological lesions among Egyptian children. MATERIALS AND METHODS: Records of biopsies submitted to the department of oral and maxillofacial pathology from the year 1999 to 2019 were retrieved and reassessed for all cases under the age of 18 years. Information on age, sex, location of the lesion, and the histopathologic diagnosis was analyzed. RESULTS: Over the course of twenty-one years, 1108 specimens were analyzed where reactive soft tissue lesions, which accounted for 397 (35.8%) of all cases ranked the highest presented category, followed by inflammatory odontogenic cysts, which accounted for 213 cases (19.2%). With 208 cases, the inflammatory radicular cyst was on the top of the most common 20 lesions, followed by pyogenic granuloma (160 cases). Malignancy was found in 19 cases, with soft tissue tumors (10 cases) being the most common, followed by salivary gland (5 cases) and bone pathologies (4 cases). CONCLUSIONS: The frequency of oral and maxillofacial pathological lesions among Egyptian children increased over the years but remained consistent with global trends. CLINICAL RELEVANCE: This is the first study evaluating the relative frequency of oral and maxillofacial pathological lesions among Egyptian children and provides an insight into the most commonly encountered pediatric pathologies. This may aid in the understanding of the most prevalent oral lesions that impact the pediatric population, as well as providing the key to early detection of lesions.


Assuntos
Doenças da Boca , Cistos Odontogênicos , Adolescente , Biópsia , Criança , Egito/epidemiologia , Humanos , Doenças da Boca/epidemiologia , Patologia Bucal , Estudos Retrospectivos
10.
J Oral Pathol Med ; 51(2): 194-205, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34704302

RESUMO

BACKGROUND: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. METHODS: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. RESULTS: Oral lichen planus patients had statistically higher scores than the controls in the majority of the PSQI sub-items (p-values < 0.001**). Moreover, OLPs had higher scores in the HAM-D, HAM-A, NRS, and T-PRI (p-values < 0.001**). No differences in the PSQI sub-items' scores were found between the K-OLPs and nK-OLPs, although nK-OLPs suffered from higher levels of anxiety, depression, and pain (p-values: HAM-A, 0.007**, HAM-D, 0.009**, NRS, <0.001**, T-PRI, <0.001**). The female gender, anxiety, depression (p-value: 0.007**, 0.001**, 0.020*) and the intensity of pain, anxiety, and depression (p-value: 0.006**, <0.001**, 0.014*) were independent predictors of poor sleep (PSQI > 5) in K-OLPs and nK-OLPs, respectively. The PSQI's validation demonstrated good internal consistency and reliability of both the total and subscale of the PSQI. CONCLUSIONS: The OLPs reported an overall impaired QoS, which seemed to be an independent parameter according to the regression analysis. Hence, clinicians should assess QoS in OLPs and treat sleep disturbances in order to improve OLPs management.


Assuntos
Líquen Plano Bucal , Transtornos do Sono-Vigília , Ansiedade/epidemiologia , Estudos de Casos e Controles , Depressão/diagnóstico , Depressão/epidemiologia , Feminino , Humanos , Líquen Plano Bucal/complicações , Líquen Plano Bucal/epidemiologia , Patologia Bucal , Reprodutibilidade dos Testes , Sono , Transtornos do Sono-Vigília/diagnóstico , Transtornos do Sono-Vigília/epidemiologia , Inquéritos e Questionários
11.
J Dent Educ ; 86(1): 4-11, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34403494

RESUMO

OBJECTIVES: The presentation-assimilation-discussion (PAD) class is a novel teaching method in which half the class time is allocated for the instructor's presentation and the other half for student's assimilation and discussion. This study evaluates and compares the teaching outcomes of the PAD class and traditional lecture-based method in oral pathology courses in School of Stomatology, Kunming Medical University. MATERIALS AND METHODS: The experimental and control groups included 88 undergraduates from Class 2017 and 72 undergraduates from Class 2016, respectively. The PAD method was applied on the experimental group in 2019, whereas the traditional lecture-based method was applied on the control group in 2018. The two groups' teaching outcomes were compared using final theory tests, biopsy diagnostic tests, and questionnaires. The Mann-Whitney U-test and independent-sample t-test were adopted for statistical analysis. RESULTS: In five multiple-choice questions examining the same knowledge point from final theory tests, the distribution of the final scores showed a statistically significant difference between the two groups (p < 0.05). In the biopsy diagnostic tests, the experimental group scored higher than the control group (p < 0.05). In the questionnaires, there was no statistically significant difference for the "enhancing knowledge mastery" item (p > 0.05). However, the experimental group showed significant superiority in the remaining nine items (p < 0.05). [Correction added on August 30, 2021, after first online publication: The data value p was corrected in the last sentence of result section.] CONCLUSIONS: Compared with the traditional lecture-based teaching, the PAD class stimulated a passion for learning among students and results in improved teaching outcomes. Therefore, the application of PAD class in oral pathology teaching should be recommended.


Assuntos
Aprendizagem , Patologia Bucal , Humanos , Estudantes , Inquéritos e Questionários , Ensino , Universidades
13.
Arq. odontol ; 58: 3-10, 2022. graf
Artigo em Português | LILACS, BBO - Odontologia | ID: biblio-1380264

RESUMO

Objetivo: Investigar as percepções e atitudes de pais/responsáveis sobre cuidados relacionados à saúde bucal das crianças por meio de um estudo descritivo. Métodos: Foi aplicado um questionário semiestruturado aos pais/responsáveis de crianças atendidas nas clinicas de Odontopediatria da Pontifícia Universidade Católica de Minas Gerais (PUC-MG) em 78 pais/responsáveis. O questionário apresentava questões sociodemográficas, assim como questões específicas relacionadas aos cuidados e atitudes para a saúde bucal de seus filhos/crianças. Análise descritiva e exploratória, por meio de médias, frequências e porcentagens foram realizadas e ilustradas por meio de figuras. Resultados: Embora a maioria dos entrevistados tenha alegado já terem recebido informações a respeito dos cuidados bucais infantis, pais/responsáveis consideraram o momento propício para a primeira visita ao dentista somente após o 1º ano de vida, período inadequado para o aleitamento materno, além da utilização inadequada de chupeta e mamadeira por longos períodos e do período para a inserção do hábito da escovação. Além disso, temáticas relacionadas à erosão dentária, teste da linguinha e a importância do íon fluoreto para a saúde bucal foram os assuntos classificados com mais dúvidas. Conclusão: Em geral, as atitudes dos pais e responsáveis não se mostraram adequadas, apesar de possuírem informações prévias no que tange a saúde bucal das crianças. Com isso, verifica-se a necessidade de enfatizar mais a fundo questões referentes a esta temática e diferentes meios para a difusão deste tipo de informação.


Aim: To investigate the perceptions and attitudes of parents/guardians about oral health care for children through a descriptive/cross-sectional study. Methods: A semi-structured questionnaire was applied to 78 parents/guardians of children seen at the Pediatric Dentistry Clinics of the Pontific Catholic University of Minas Gerais (PUC-MG). The questionnaire presented sociodemographic questions, as well as specific questions related to the care and attitudes towards the oral health of their children. Exploratory and descriptive analyses by means of means, frequencies,and percentages were performed and illustrated in figures. Results: Although most of the interviewees claimed to have already received information regarding children's oral care, they considered the proper time for the first visit to the dentist only after the 1st year of life, an inadequate period for breastfeeding, as well as the inappropriate use of pacifiers and bottles for long periods and an improper period for the insertion of the habit of tooth brushing. Furthermore, issues related to dental erosion, the tongue test, and the importance of fluoride ions for oral health were the subjects classified with the most doubts. Conclusion: In general, the attitudes of parents and guardians proved to be inappropriate, although they have previous information regarding the oral health of children. Thus, there is a need to offer a more in-depth emphasis on issues related to this theme and different means through which to disseminate this type of information.


Assuntos
Patologia Bucal , Erosão Dentária , Aleitamento Materno , Saúde Bucal , Odontopediatria , Cárie Dentária
14.
Braz. j. oral sci ; 20: e211817, jan.-dez. 2021. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1253160

RESUMO

Tumors of the maxillomandibular complex are a heterogeneous group of lesions with a wide spectrum of clinical and histopathological characteristics. Aim: To evaluate the prevalence of odontogenic and non-odontogenic tumors associated with maxillary bones in a Reference Center for Oral Lesions. Methods: A cross-sectional study based on the medical records of a Reference Center for Oral Lesions at the State University of Feira de Santana, from 2006 to 2018. The data was initially analyzed in a descriptive manner. For bivariate analysis, Pearson's chi-square test was applied. The level of significance was set at 5%, where p≤ 0.05 is considered significant. Results: The prevalence of tumors was 2.27%. The average age of the individuals was 22.2 (± 15.1) years, the majority being up to 39 years (79.59%) and female (69.40%). A statistically significant difference was observed in relation to age (p = 0.00), as well as regarding the location of tumors in the anterior or posterior region (p = 0.02). Odontogenic tumors were benign, with odontoma being most frequent (46.90%), followed by ameloblastoma (16.30%). As for the non-odontogenic, neurofibroma (4.10%) and osteoma (4.10%) were the most common across the benign, while osteosarcoma accounted for 6.10% of cases. Conclusion: Odontogenic tumors were the most frequent in women, with age up to 39 years, odontoma being most common in the posterior region of the mandible. Among nonodontogenic tumors, central neurofibroma and osteoma were the most common. Osteosarcoma was more frequent in men over 40 years old and in the mandible region


Assuntos
Patologia Bucal , Neoplasias Maxilomandibulares/epidemiologia , Estudos Transversais , Diagnóstico
15.
Stomatologiia (Mosk) ; 100(4): 31-36, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34357725

RESUMO

OBJECTIVE: The aim of the work was to determine the informativeness of the assessment of biochemical markers in the gingival fluid with destructive bone changes in the peri-implantation area, primary tumor lesion of the alveolar processes of the jaws and metastatic destruction of the jaw bone tissue in cancer of the large salivary glands. The study included 51 patients aged 30 to 75 years of both sexes. Depending on the genesis of destruction of the bone tissue of the lower jaw, three groups of patients were identified. Group 1 - 20 patients with peri-implantitis. Group 2 - 22 patients diagnosed with cancer of the oral floor mucosa (ICD C04) with erosion of the cortical bone or dental socket by a primary tumor. Group 3 - 9 patients with adenocarcinoma of the large salivary glands with metastatic lesions of the lower jaw. 15 people were practically healthy persons without periodontal pathology. The test material was gingival fluid or exudate from peri-implantation pockets. The content of cathepsin K, tartrate-resistant acid phosphatase (TAP) was determined by the enzyme immunoassay, and the bone fraction of alkaline phosphatase (BAP) was determined by the kinetic method. RESULTS: As a result, it was found that in group 1 in the exudate of the peri-implantation sulcus, the content of cathepsin K increased in comparison with the control by 2.5 times (p<0.05), TAP by 1.6 times (p<0.05). in groups 1 and 2, there was a moderate increase in the production of activated osteoblasts of KAP. In cancer of the mucous membrane of the floor of the mouth, a tenfold increase in the concentration of cathepsin K and TAP in the gingival fluid was observed. With metastatic lesions of the jaw in patients with adenocarcinoma of the large salivary glands, along with a multiple increase in the concentration of cathepsin K and TAP in the gingival fluid, there was a twenty-fold increase in the bone formation marker BAP, which indicated a mixed type of metastases and was a differential diagnostic criterion for metastatic lesion of bone tissue in comparison with the primary metastatic lesion of bone tissue. CONCLUSION: Thus, biochemical markers are sensitive indicators of remodeling of bone tissue both in local inflammatory and destructive processes in peri-implantitis and in primary and metastatic tumor lesions of the jaws.


Assuntos
Perda do Osso Alveolar , Implantes Dentários , Neoplasias , Peri-Implantite , Biomarcadores/análise , Feminino , Líquido do Sulco Gengival/química , Humanos , Masculino , Patologia Bucal
17.
Appl Immunohistochem Mol Morphol ; 29(10): 781-790, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34320560

RESUMO

A proper antibody panel selection is one of the most important factors to reach an adequate diagnosis in challenging cases. This retrospective study was designed to determine the contribution of immunohistochemistry (IHC) in the primary diagnosis of oral diseases in one of the main services of oral pathology in the State of São Paulo, Brazil, and to identify the most common antibodies used, and recommend diagnostic algorithms based on our experience with challenging lesions. A total of 1698 IHC stains were performed in 401 cases from a total of 28,804 cases received from public dental clinics and private dental practitioners within a period of 13 years, representing a frequency of 1.4% of IHC solicitations. Among these, 112 (28%) were mandatory to reach a final diagnosis and 255 (63.6%) were confirmative. In 34 (8.4%) cases, it was not possible to reach a conclusive/final diagnosis, even with IHC. Regarding the nature of the lesions, 210 (52.3%) were benign, 163 (40.6%) were malignant tumors, 13 (3.2%) were reactive, 10 (2.5%) were premalignant, and 5 (1.2%) were lesions of uncertain malignancy. Small amount of tissue of some incisional biopsies, overlapping features of spindle cell lesions (epithelial, neural, melanocytic, smooth muscle, endothelial, and fibroblastic/myofibroblastic cell differentiation), and overlapping features of salivary gland lesions were the most frequent challenges in which IHC stains were requested. Spindle cell lesions were the most frequent (22%) among all cases that required IHC to reach a final diagnosis. The implementation of IHC for routine practice requires a wide range of markers, proper antibody selection, and knowledge to interpret the subjectivity of staining. The inherent limitation of incisional biopsies was pointed as a reason to inconclusive diagnosis, despite a wide range of antibodies that our laboratory displays.


Assuntos
Imuno-Histoquímica , Neoplasias Bucais , Patologia Bucal , Lesões Pré-Cancerosas , Brasil , Feminino , Humanos , Masculino , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/metabolismo , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/diagnóstico , Lesões Pré-Cancerosas/metabolismo , Lesões Pré-Cancerosas/patologia , Estudos Retrospectivos
18.
Med Oral Patol Oral Cir Bucal ; 26(5): e676-e683, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34162820

RESUMO

BACKGROUND: Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. The objective was to analyze the clinicopathological features of NDCs diagnosed in two oral and maxillofacial pathology services in the Brazilian northeast. MATERIAL AND METHODS: A retrospective clinicopathologic study was performed. A total of 18,121 clinical records of oral lesions from two oral and maxillofacial pathology services in Brazil were analyzed (2000-2020). All NDCs cases were revised and demographic, clinical, radiographic, and histopathological data were collected. RESULTS: Among 18,121 diagnoses in the oral pathology services, 45 (0.2%) were NDCs. The series comprises 24 males (53.3%) and 21 females (46.7%), with a mean age of 43.2 years-old. Most lesions were asymptomatic (n = 27, 60%) with an mean size of 2.1 cm. Microscopically, the non-keratinized stratified squamous epithelium was the most common (66.7%). However, in 88.9% of cases, the epithelial lining was varied and composed of two or more types of epithelium. There was no significant association between the type of epithelium and the size of the cysts (p = 0.389). Nerve, blood vessels, hemorrhage, and chronic inflammatory infiltrate were commonly observed. In contrast, there was a low frequency of mucous glands, sebaceous glands, cholesterol clefts, and multinucleated giant cells. CONCLUSIONS: The clinical, radiographic, and microscopic findings observed in this study are similar to those reported in the literature. Due to the morphological diversity of NDC, it is needed to correlate its histopathological features with the clinical and radiographic findings to establish a correct diagnosis.


Assuntos
Cistos , Cistos não Odontogênicos , Adulto , Brasil , Cistos/diagnóstico por imagem , Cistos/epidemiologia , Feminino , Humanos , Masculino , Cistos não Odontogênicos/diagnóstico por imagem , Cistos não Odontogênicos/epidemiologia , Patologia Bucal , Encaminhamento e Consulta , Estudos Retrospectivos
19.
Arch Endocrinol Metab ; 64(6): 664-672, 2021 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-34033275

RESUMO

Antiresorptive therapy is the main form of prevention of osteoporotic or fragility fractures. Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but severe adverse reaction to antiresorptive and antiangiogenic drugs. Physicians and dentists caring for patients taking these drugs and requiring invasive procedures face a difficult decision because of the potential risk of MRONJ. The aim of this study was to discuss the risk factors for the development of MRONJ and prevention of this complication in patients with osteoporosis taking antiresorptive drugs and requiring invasive dental treatment. For this goal, a task force with representatives from three professional associations was appointed to review the pertinent literature and discuss systemic and local risk factors, prevention of MRONJ in patients with osteoporosis, and management of established MRONJ. Although scarce evidence links the use of antiresorptive agents in the context of osteoporosis to the development of MRONJ, these agents are considered a risk factor for this complication. Despite the rare reports of MRONJ in patients with osteoporosis, the severity of symptoms and impact of MRONJ in the patients' quality of life make it imperative for health care professionals to consider this complication when planning invasive dental procedures.


Assuntos
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos , Conservadores da Densidade Óssea , Medicina Bucal , Osteoporose , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/etiologia , Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/prevenção & controle , Conservadores da Densidade Óssea/efeitos adversos , Brasil , Difosfonatos , Humanos , Osteoporose/induzido quimicamente , Osteoporose/tratamento farmacológico , Osteoporose/prevenção & controle , Patologia Bucal , Qualidade de Vida
20.
J Oral Pathol Med ; 50(7): 649-659, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33811413

RESUMO

OBJECTIVE: The steady and continued increase of the Journal of Oral Pathology & Medicine's (JOPM) popularity prompted a bibliometric analysis of the journal. The purpose was to assess the significance and effect of the published research articles in the Journal from 1972 and 2020, aiding the identification of landmark articles. We performed a bibliometric analysis using the top 100 cited papers in the Journal of Oral Pathology & Medicine. MATERIALS AND METHODS: An extensive review of the Web of Science was undertaken. Standard information such as author details, affiliated institutions, publication year and the country of origin was recorded. RESULTS: The top 100 cited articles in JOPM were assessed. The maximum and minimum number of citations in the top 100 articles was 1459 and 95, respectively. A total of 16 790 citations were recorded for these 100 articles. Authors were affiliated to 28 different countries, 17 research articles from the UK and 12 from the USA. Other countries furnished seven or fewer articles. CONCLUSION: This bibliometric analysis provides a synopsis of research published in the journal over a 48-year period. Recent interest in the journal shows a healthy increase in submissions and profile.


Assuntos
Medicina Bucal , Patologia Bucal , Bibliometria , Humanos
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